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Protein

BRI3-binding protein

Gene

BRI3BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tumorigenesis and may function by stabilizing p53/TP53.1 Publication

Protein family/group databases

TCDBi1.A.74.2.2. the mitsugumin 23 (mg23) family.

Names & Taxonomyi

Protein namesi
Recommended name:
BRI3-binding protein
Short name:
I3-binding protein
Alternative name(s):
Cervical cancer 1 proto-oncogene-binding protein KG19
HCCRBP-1
Gene namesi
Name:BRI3BPImported
Synonyms:KG19Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14251. BRI3BP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA25423.

Polymorphism and mutation databases

BioMutaiBRI3BP.
DMDMi74730999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251BRI3-binding proteinPRO_0000229747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291N6-acetyllysineCombined sources
Modified residuei248 – 2481PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8WY22.
MaxQBiQ8WY22.
PaxDbiQ8WY22.
PeptideAtlasiQ8WY22.
PRIDEiQ8WY22.
TopDownProteomicsiQ8WY22.

PTM databases

iPTMnetiQ8WY22.
PhosphoSiteiQ8WY22.
SwissPalmiQ8WY22.

Expressioni

Tissue specificityi

Most abundantly expressed in brain, liver and kidney. Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas.2 Publications

Gene expression databases

BgeeiENSG00000184992.
CleanExiHS_BRI3BP.
GenevisibleiQ8WY22. HS.

Organism-specific databases

HPAiHPA014957.

Interactioni

Subunit structurei

Interacts with LETMD1.1 Publication

Protein-protein interaction databases

BioGridi126665. 20 interactions.
IntActiQ8WY22. 6 interactions.
MINTiMINT-1131578.

Structurei

3D structure databases

ProteinModelPortaliQ8WY22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili217 – 24731Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ5B. Eukaryota.
ENOG410ZDYG. LUCA.
GeneTreeiENSGT00390000002024.
HOGENOMiHOG000285949.
HOVERGENiHBG058925.
InParanoidiQ8WY22.
OMAiSCLYILQ.
OrthoDBiEOG091G0P3Q.
PhylomeDBiQ8WY22.
TreeFamiTF332238.

Family and domain databases

InterProiIPR033367. BRI3BP.
[Graphical view]
PANTHERiPTHR31253. PTHR31253. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WY22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASGGPL ARAGLLLLLL LLLLLGLLAP GAQGARGRGG AEKNSYRRTV
60 70 80 90 100
NTFSQSVSSL FGEDNVRAAQ KFLARLTERF VLGVDMFVET LWKVWTELLD
110 120 130 140 150
VLGLDVSNLS QYFSPASVSS SPARALLLVG VVLLAYWFLS LTLGFTFSVL
160 170 180 190 200
HVVFGRFFWI VRVVLFSMSC VYILHKYEGE PENAVLPLCF VVAVYFMTGP
210 220 230 240 250
MGFYWRSSPS GPSNPSNPSV EEKLEHLEKQ VRLLNIRLNR VLESLDRSKD

K
Length:251
Mass (Da):27,836
Last modified:March 1, 2002 - v1
Checksum:iDBC7ECB411010F71
GO

Sequence cautioni

The sequence AAL33003 differs from that shown. Reason: Frameshift at positions 43, 47 and 59. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871F → S in AAL33003 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284094 mRNA. Translation: AAL54382.1.
BC034525 mRNA. Translation: AAH34525.1.
AF283671 mRNA. Translation: AAL33003.2. Frameshift.
CCDSiCCDS9262.1.
RefSeqiNP_542193.3. NM_080626.5.
UniGeneiHs.596464.

Genome annotation databases

EnsembliENST00000341446; ENSP00000340761; ENSG00000184992.
GeneIDi140707.
KEGGihsa:140707.
UCSCiuc001uha.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284094 mRNA. Translation: AAL54382.1.
BC034525 mRNA. Translation: AAH34525.1.
AF283671 mRNA. Translation: AAL33003.2. Frameshift.
CCDSiCCDS9262.1.
RefSeqiNP_542193.3. NM_080626.5.
UniGeneiHs.596464.

3D structure databases

ProteinModelPortaliQ8WY22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126665. 20 interactions.
IntActiQ8WY22. 6 interactions.
MINTiMINT-1131578.

Protein family/group databases

TCDBi1.A.74.2.2. the mitsugumin 23 (mg23) family.

PTM databases

iPTMnetiQ8WY22.
PhosphoSiteiQ8WY22.
SwissPalmiQ8WY22.

Polymorphism and mutation databases

BioMutaiBRI3BP.
DMDMi74730999.

Proteomic databases

EPDiQ8WY22.
MaxQBiQ8WY22.
PaxDbiQ8WY22.
PeptideAtlasiQ8WY22.
PRIDEiQ8WY22.
TopDownProteomicsiQ8WY22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341446; ENSP00000340761; ENSG00000184992.
GeneIDi140707.
KEGGihsa:140707.
UCSCiuc001uha.2. human.

Organism-specific databases

CTDi140707.
GeneCardsiBRI3BP.
HGNCiHGNC:14251. BRI3BP.
HPAiHPA014957.
MIMi615627. gene.
neXtProtiNX_Q8WY22.
PharmGKBiPA25423.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ5B. Eukaryota.
ENOG410ZDYG. LUCA.
GeneTreeiENSGT00390000002024.
HOGENOMiHOG000285949.
HOVERGENiHBG058925.
InParanoidiQ8WY22.
OMAiSCLYILQ.
OrthoDBiEOG091G0P3Q.
PhylomeDBiQ8WY22.
TreeFamiTF332238.

Miscellaneous databases

ChiTaRSiBRI3BP. human.
GenomeRNAii140707.
PROiQ8WY22.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184992.
CleanExiHS_BRI3BP.
GenevisibleiQ8WY22. HS.

Family and domain databases

InterProiIPR033367. BRI3BP.
[Graphical view]
PANTHERiPTHR31253. PTHR31253. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBRI3B_HUMAN
AccessioniPrimary (citable) accession number: Q8WY22
Secondary accession number(s): Q8WY23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.