Q8WY21 (SORC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
VPS10 domain-containing receptor SorCS1
Short name=hSorCS

Gene names

Name:	SORCS1
Synonyms:	SORCS

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1168 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Detected in fetal and infant brain and in fetal retina.
Sequence similarities	Belongs to the VPS10-related sortilin family. SORCS subfamily. Contains 5 BNR repeats. Contains 1 PKD domain.
Sequence caution	The sequence BAD92379.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI40754.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40755.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	neuropeptide receptor activity Non-traceable author statement Ref.6. Source: UniProtKB protein binding Inferred from physical interaction Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WY21-1)

Also known as: B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WY21-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1125-1168: RVALPSPPSP...RGSAGAQYAI → KIPGINVYAQ...TKEIPTYVNV

Note: Gene prediction based on EST data.

Isoform 3 (identifier: Q8WY21-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1125-1168: RVALPSPPSP...RGSAGAQYAI → KIPGINVYAQ...EKVESQLIGK

Isoform 4 (identifier: Q8WY21-4)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     1125-1168: RVALPSPPSP...RGSAGAQYAI → CVSLYPRSPTPDLFLLPDRFRSMCYSDVHSSDGFY

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 1168	1135	VPS10 domain-containing receptor SorCS1		PRO_0000033170
Regions
	Topological domain	34 – 1099	1066	Lumenal Potential
	Transmembrane	1100 – 1120	21	Helical; Potential
	Topological domain	1121 – 1168	48	Cytoplasmic Potential
	Repeat	208 – 219	12	BNR 1
	Repeat	256 – 267	12	BNR 2
	Repeat	492 – 503	12	BNR 3
	Repeat	569 – 580	12	BNR 4
	Repeat	611 – 622	12	BNR 5
	Domain	803 – 894	92	PKD
Amino acid modifications
	Glycosylation	184	1	N-linked (GlcNAc...) Potential
	Glycosylation	352	1	N-linked (GlcNAc...) Potential
	Glycosylation	433	1	N-linked (GlcNAc...) Potential
	Glycosylation	765	1	N-linked (GlcNAc...) Potential
	Glycosylation	776	1	N-linked (GlcNAc...) Potential
	Glycosylation	816	1	N-linked (GlcNAc...) Potential
	Glycosylation	847	1	N-linked (GlcNAc...) Potential
	Glycosylation	908	1	N-linked (GlcNAc...) Potential
	Glycosylation	929	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1125 – 1168	44	RVALP…AQYAI → KIPGINVYAQMQNEKEQEMI SPVSHSESRPNVPQTELRRP GQLIDEKVESQLIGSISIVA ENQSTKEIPTYVNV in isoform 2.		VSP_006204
	Alternative sequence	1125 – 1168	44	RVALP…AQYAI → KIPGINVYAQMQNEKEQEMI SPVSHSESRPNVPQTELRRP GQLIDEKVESQLIGK in isoform 3.		VSP_015140
	Alternative sequence	1125 – 1168	44	RVALP…AQYAI → CVSLYPRSPTPDLFLLPDRF RSMCYSDVHSSDGFY in isoform 4.		VSP_015141
	Natural variant	223	1	K → N in a breast cancer sample; somatic mutation. Ref.7		VAR_036374
Experimental info
	Sequence conflict	231	1	S → G in AAL56667. Ref.1
	Sequence conflict	487	1	N → Y in AAL56667. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (B) [UniParc]. Last modified May 24, 2005. Version 3. Checksum: BAF8D4FB87A4F998	FASTA	1,168	129,635
	10 20 30 40 50 60 MGKVGAGGGS QARLSALLAG AGLLILCAPG VCGGGSCCPS PHPSSAPRSA STPRGFSHQG 70 80 90 100 110 120 RPGRAPATPL PLVVRPLFSV APGDRALSLE RARGTGASMA VAARSGRRRR SGADQEKAER 130 140 150 160 170 180 GEGASRSPRG VLRDGGQQEP GTRERDPDKA TRFRMEELRL TSTTFALTGD SAHNQAMVHW 190 200 210 220 230 240 SGHNSSVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL NDKVGLKTIL SYLYVCPTNK 250 260 270 280 290 300 RKIMLLTDPE IESSLLISSD EGATYQKYRL NFYIQSLLFH PKQEDWILAY SQDQKLYSSA 310 320 330 340 350 360 EFGRRWQLIQ EGVVPNRFYW SVMGSNKEPD LVHLEARTVD GHSHYLTCRM QNCTEANRNQ 370 380 390 400 410 420 PFPGYIDPDS LIVQDHYVFV QLTSGGRPHY YVSYRRNAFA QMKLPKYALP KDMHVISTDE 430 440 450 460 470 480 NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVQSSRG PEGNIMIDLY EVAGIKGMFL 490 500 510 520 530 540 ANKKIDNQVK TFITYNKGRD WRLLQAPDTD LRGDPVHCLL PYCSLHLHLK VSENPYTSGI 550 560 570 580 590 600 IASKDTAPSI IVASGNIGSE LSDTDISMFV SSDAGNTWRQ IFEEEHSVLY LDQGGVLVAM 610 620 630 640 650 660 KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG EETLIMTVFG HFSHRSEWQL 670 680 690 700 710 720 VKVDYKSIFD RRCAEEDYRP WQLHSQGEAC IMGAKRIYKK RKSERKCMQG KYAGAMESEP 730 740 750 760 770 780 CVCTEADFDC DYGYERHSNG QCLPAFWFNP SSLSKDCSLG QSYLNSTGYR KVVSNNCTDG 790 800 810 820 830 840 VREQYTAKPQ KCPGKAPRGL RIVTADGKLT AEQGHNVTLM VQLEEGDVQR TLIQVDFGDG 850 860 870 880 890 900 IAVSYVNLSS MEDGIKHVYQ NVGIFRVTVQ VDNSLGSDSA VLYLHVTCPL EHVHLSLPFV 910 920 930 940 950 960 TTKNKEVNAT AVLWPSQVGT LTYVWWYGNN TEPLITLEGS ISFRFTSEGM NTITVQVSAG 970 980 990 1000 1010 1020 NAILQDTKTI AVYEEFRSLR LSFSPNLDDY NPDIPEWRRD IGRVIKKSLV EATGVPGQHI 1030 1040 1050 1060 1070 1080 LVAVLPGLPT TAELFVLPYQ DPAGENKRST DDLEQISELL IHTLNQNSVH FELKPGVRVL 1090 1100 1110 1120 1130 1140 VHAAHLTAAP LVDLTPTHSG SAMLMLLSVV FVGLAVFVIY KFKRRVALPS PPSPSTQPGD 1150 1160 SSLRLQRARH ATPPSTPKRG SAGAQYAI
	Isoform 2 [UniParc]. Checksum: 1B7EE3F03DC9CDE0	FASTA	1,198	133,373
	10 20 30 40 50 60 MGKVGAGGGS QARLSALLAG AGLLILCAPG VCGGGSCCPS PHPSSAPRSA STPRGFSHQG 70 80 90 100 110 120 RPGRAPATPL PLVVRPLFSV APGDRALSLE RARGTGASMA VAARSGRRRR SGADQEKAER 130 140 150 160 170 180 GEGASRSPRG VLRDGGQQEP GTRERDPDKA TRFRMEELRL TSTTFALTGD SAHNQAMVHW 190 200 210 220 230 240 SGHNSSVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL NDKVGLKTIL SYLYVCPTNK 250 260 270 280 290 300 RKIMLLTDPE IESSLLISSD EGATYQKYRL NFYIQSLLFH PKQEDWILAY SQDQKLYSSA 310 320 330 340 350 360 EFGRRWQLIQ EGVVPNRFYW SVMGSNKEPD LVHLEARTVD GHSHYLTCRM QNCTEANRNQ 370 380 390 400 410 420 PFPGYIDPDS LIVQDHYVFV QLTSGGRPHY YVSYRRNAFA QMKLPKYALP KDMHVISTDE 430 440 450 460 470 480 NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVQSSRG PEGNIMIDLY EVAGIKGMFL 490 500 510 520 530 540 ANKKIDNQVK TFITYNKGRD WRLLQAPDTD LRGDPVHCLL PYCSLHLHLK VSENPYTSGI 550 560 570 580 590 600 IASKDTAPSI IVASGNIGSE LSDTDISMFV SSDAGNTWRQ IFEEEHSVLY LDQGGVLVAM 610 620 630 640 650 660 KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG EETLIMTVFG HFSHRSEWQL 670 680 690 700 710 720 VKVDYKSIFD RRCAEEDYRP WQLHSQGEAC IMGAKRIYKK RKSERKCMQG KYAGAMESEP 730 740 750 760 770 780 CVCTEADFDC DYGYERHSNG QCLPAFWFNP SSLSKDCSLG QSYLNSTGYR KVVSNNCTDG 790 800 810 820 830 840 VREQYTAKPQ KCPGKAPRGL RIVTADGKLT AEQGHNVTLM VQLEEGDVQR TLIQVDFGDG 850 860 870 880 890 900 IAVSYVNLSS MEDGIKHVYQ NVGIFRVTVQ VDNSLGSDSA VLYLHVTCPL EHVHLSLPFV 910 920 930 940 950 960 TTKNKEVNAT AVLWPSQVGT LTYVWWYGNN TEPLITLEGS ISFRFTSEGM NTITVQVSAG 970 980 990 1000 1010 1020 NAILQDTKTI AVYEEFRSLR LSFSPNLDDY NPDIPEWRRD IGRVIKKSLV EATGVPGQHI 1030 1040 1050 1060 1070 1080 LVAVLPGLPT TAELFVLPYQ DPAGENKRST DDLEQISELL IHTLNQNSVH FELKPGVRVL 1090 1100 1110 1120 1130 1140 VHAAHLTAAP LVDLTPTHSG SAMLMLLSVV FVGLAVFVIY KFKRKIPGIN VYAQMQNEKE 1150 1160 1170 1180 1190 QEMISPVSHS ESRPNVPQTE LRRPGQLIDE KVESQLIGSI SIVAENQSTK EIPTYVNV
	Isoform 3 (C) [UniParc]. Checksum: 0C2E5DACD6A47209	FASTA	1,179	131,327
	10 20 30 40 50 60 MGKVGAGGGS QARLSALLAG AGLLILCAPG VCGGGSCCPS PHPSSAPRSA STPRGFSHQG 70 80 90 100 110 120 RPGRAPATPL PLVVRPLFSV APGDRALSLE RARGTGASMA VAARSGRRRR SGADQEKAER 130 140 150 160 170 180 GEGASRSPRG VLRDGGQQEP GTRERDPDKA TRFRMEELRL TSTTFALTGD SAHNQAMVHW 190 200 210 220 230 240 SGHNSSVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL NDKVGLKTIL SYLYVCPTNK 250 260 270 280 290 300 RKIMLLTDPE IESSLLISSD EGATYQKYRL NFYIQSLLFH PKQEDWILAY SQDQKLYSSA 310 320 330 340 350 360 EFGRRWQLIQ EGVVPNRFYW SVMGSNKEPD LVHLEARTVD GHSHYLTCRM QNCTEANRNQ 370 380 390 400 410 420 PFPGYIDPDS LIVQDHYVFV QLTSGGRPHY YVSYRRNAFA QMKLPKYALP KDMHVISTDE 430 440 450 460 470 480 NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVQSSRG PEGNIMIDLY EVAGIKGMFL 490 500 510 520 530 540 ANKKIDNQVK TFITYNKGRD WRLLQAPDTD LRGDPVHCLL PYCSLHLHLK VSENPYTSGI 550 560 570 580 590 600 IASKDTAPSI IVASGNIGSE LSDTDISMFV SSDAGNTWRQ IFEEEHSVLY LDQGGVLVAM 610 620 630 640 650 660 KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG EETLIMTVFG HFSHRSEWQL 670 680 690 700 710 720 VKVDYKSIFD RRCAEEDYRP WQLHSQGEAC IMGAKRIYKK RKSERKCMQG KYAGAMESEP 730 740 750 760 770 780 CVCTEADFDC DYGYERHSNG QCLPAFWFNP SSLSKDCSLG QSYLNSTGYR KVVSNNCTDG 790 800 810 820 830 840 VREQYTAKPQ KCPGKAPRGL RIVTADGKLT AEQGHNVTLM VQLEEGDVQR TLIQVDFGDG 850 860 870 880 890 900 IAVSYVNLSS MEDGIKHVYQ NVGIFRVTVQ VDNSLGSDSA VLYLHVTCPL EHVHLSLPFV 910 920 930 940 950 960 TTKNKEVNAT AVLWPSQVGT LTYVWWYGNN TEPLITLEGS ISFRFTSEGM NTITVQVSAG 970 980 990 1000 1010 1020 NAILQDTKTI AVYEEFRSLR LSFSPNLDDY NPDIPEWRRD IGRVIKKSLV EATGVPGQHI 1030 1040 1050 1060 1070 1080 LVAVLPGLPT TAELFVLPYQ DPAGENKRST DDLEQISELL IHTLNQNSVH FELKPGVRVL 1090 1100 1110 1120 1130 1140 VHAAHLTAAP LVDLTPTHSG SAMLMLLSVV FVGLAVFVIY KFKRKIPGIN VYAQMQNEKE 1150 1160 1170 QEMISPVSHS ESRPNVPQTE LRRPGQLIDE KVESQLIGK
	Isoform 4 (A) [UniParc]. Checksum: 46135ADD8F627AAE	FASTA	1,159	129,141
	10 20 30 40 50 60 MGKVGAGGGS QARLSALLAG AGLLILCAPG VCGGGSCCPS PHPSSAPRSA STPRGFSHQG 70 80 90 100 110 120 RPGRAPATPL PLVVRPLFSV APGDRALSLE RARGTGASMA VAARSGRRRR SGADQEKAER 130 140 150 160 170 180 GEGASRSPRG VLRDGGQQEP GTRERDPDKA TRFRMEELRL TSTTFALTGD SAHNQAMVHW 190 200 210 220 230 240 SGHNSSVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL NDKVGLKTIL SYLYVCPTNK 250 260 270 280 290 300 RKIMLLTDPE IESSLLISSD EGATYQKYRL NFYIQSLLFH PKQEDWILAY SQDQKLYSSA 310 320 330 340 350 360 EFGRRWQLIQ EGVVPNRFYW SVMGSNKEPD LVHLEARTVD GHSHYLTCRM QNCTEANRNQ 370 380 390 400 410 420 PFPGYIDPDS LIVQDHYVFV QLTSGGRPHY YVSYRRNAFA QMKLPKYALP KDMHVISTDE 430 440 450 460 470 480 NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVQSSRG PEGNIMIDLY EVAGIKGMFL 490 500 510 520 530 540 ANKKIDNQVK TFITYNKGRD WRLLQAPDTD LRGDPVHCLL PYCSLHLHLK VSENPYTSGI 550 560 570 580 590 600 IASKDTAPSI IVASGNIGSE LSDTDISMFV SSDAGNTWRQ IFEEEHSVLY LDQGGVLVAM 610 620 630 640 650 660 KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG EETLIMTVFG HFSHRSEWQL 670 680 690 700 710 720 VKVDYKSIFD RRCAEEDYRP WQLHSQGEAC IMGAKRIYKK RKSERKCMQG KYAGAMESEP 730 740 750 760 770 780 CVCTEADFDC DYGYERHSNG QCLPAFWFNP SSLSKDCSLG QSYLNSTGYR KVVSNNCTDG 790 800 810 820 830 840 VREQYTAKPQ KCPGKAPRGL RIVTADGKLT AEQGHNVTLM VQLEEGDVQR TLIQVDFGDG 850 860 870 880 890 900 IAVSYVNLSS MEDGIKHVYQ NVGIFRVTVQ VDNSLGSDSA VLYLHVTCPL EHVHLSLPFV 910 920 930 940 950 960 TTKNKEVNAT AVLWPSQVGT LTYVWWYGNN TEPLITLEGS ISFRFTSEGM NTITVQVSAG 970 980 990 1000 1010 1020 NAILQDTKTI AVYEEFRSLR LSFSPNLDDY NPDIPEWRRD IGRVIKKSLV EATGVPGQHI 1030 1040 1050 1060 1070 1080 LVAVLPGLPT TAELFVLPYQ DPAGENKRST DDLEQISELL IHTLNQNSVH FELKPGVRVL 1090 1100 1110 1120 1130 1140 VHAAHLTAAP LVDLTPTHSG SAMLMLLSVV FVGLAVFVIY KFKRCVSLYP RSPTPDLFLL 1150 PDRFRSMCYS DVHSSDGFY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells." Hermey G., Keat S.J., Madsen P., Jacobsen C., Petersen C.M., Gliemann J. J. Biol. Chem. 278:7390-7396(2003) [PubMed: 12482870] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4).
[2]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"The genes for the human VPS10 domain-containing receptors are large and contain many small exons." Hampe W., Rezgaoui M., Hermans-Borgmeyer I., Schaller H.C. Hum. Genet. 108:529-536(2001) [PubMed: 11499680] [Abstract] Cited for: REVIEW.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-223.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF284756 mRNA. Translation: AAL56667.1. AY099452 mRNA. Translation: AAM43811.1. AY099453 mRNA. Translation: AAM43812.1. AB209142 mRNA. Translation: BAD92379.1. Different initiation. AL160010 , AL133395, AL356255, AL356308, AL357333 Genomic DNA. Translation: CAH70582.1. AL356255 , AL133395, AL160010, AL356308, AL357333 Genomic DNA. Translation: CAH73442.1. AL356308 , AL133395, AL160010, AL356255, AL357333 Genomic DNA. Translation: CAI14367.1. AL357333 , AL133395, AL160010, AL356255, AL356308 Genomic DNA. Translation: CAI16407.1. AL133395 , AL160010, AL356255, AL356308, AL357333 Genomic DNA. Translation: CAI40753.1. AL133395 Genomic DNA. Translation: CAI40754.1. Sequence problems. AL133395 Genomic DNA. Translation: CAI40755.1. Sequence problems. CH471066 Genomic DNA. Translation: EAW49583.1. BC131597 mRNA. Translation: AAI31598.1.
IPI	IPI00103597. IPI00412910. IPI00644354. IPI00644454.
RefSeq	NP_001013049.1. NM_001013031.2. NP_001193498.1. NM_001206569.1. NP_001193499.1. NM_001206570.1. NP_001193500.1. NM_001206571.1. NP_001193501.1. NM_001206572.1. NP_443150.3. NM_052918.4.
UniGene	Hs.591915.
3D structure databases
ProteinModelPortal	Q8WY21.
SMR	Q8WY21. Positions 274-312, 565-627, 774-891, 917-975.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WY21.
PTM databases
PhosphoSite	Q8WY21.
Polymorphism databases
DMDM	66774216.
Proteomic databases
PRIDE	Q8WY21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263054; ENSP00000263054; ENSG00000108018.
GeneID	114815.
KEGG	hsa:114815.
UCSC	uc001kyl.1. human. uc001kym.1. human. uc001kyn.1. human. uc001kyo.2. human.
Organism-specific databases
CTD	114815.
GeneCards	GC10M108323.
H-InvDB	HIX0025919.
HGNC	HGNC:16697. SORCS1.
HPA	HPA011948.
MIM	606283. gene.
neXtProt	NX_Q8WY21.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00510000046443.
HOVERGEN	HBG059252.
OMA	SGGRPHY.
PhylomeDB	Q8WY21.
Gene expression databases
ArrayExpress	Q8WY21.
Bgee	Q8WY21.
Genevestigator	Q8WY21.
Family and domain databases
InterPro	IPR022409. PKD/Chitinase_dom. IPR000601. PKD_dom. IPR006581. VPS10. [Graphical view]
Gene3D	G3DSA:2.60.40.670. PKD. 1 hit.
Pfam	PF00801. PKD. 1 hit. [Graphical view]
SMART	SM00089. PKD. 2 hits. SM00602. VPS10. 1 hit. [Graphical view]
SUPFAM	SSF49299. PKD. 2 hits.
PROSITE	PS50093. PKD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	79273.
SOURCE	Search...

Entry information

Entry name

SORC1_HUMAN

Accession

Primary (citable) accession number: Q8WY21
Secondary accession number(s): A2RRF4 , Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	May 24, 2005
Last modified:	January 25, 2012
This is version 89 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.