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Protein
Submitted name:

Down syndrome cell adhesion molecule

Gene

DSCAM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Down syndrome cell adhesion moleculeImported
Submitted name:
Down syndrome cell adhesion molecule splice variantImported
Gene namesi
Name:DSCAMImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:3039. DSCAM.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1347 – 1368HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171587.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ8WY19.
PRIDEiQ8WY19.

Expressioni

Gene expression databases

BgeeiENSG00000171587.
ExpressionAtlasiQ8WY19. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000383303.

Structurei

3D structure databases

ProteinModelPortaliQ8WY19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 57Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST57
Domaini65 – 153Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST89
Domaini159 – 252Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST94
Domaini256 – 344Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST89
Domaini348 – 437Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST90
Domaini442 – 535Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST94
Domaini539 – 635Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST97
Domaini637 – 734Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini739 – 838Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini843 – 939Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini943 – 1037Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1037 – 1129Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST93
Domaini1131 – 1225Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1226 – 1327Fibronectin type-IIIInterPro annotationAdd BLAST102

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQJM. Eukaryota.
ENOG410XQX7. LUCA.
GeneTreeiENSGT00860000133679.
HOGENOMiHOG000112277.
HOVERGENiHBG051409.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 14 hits.
InterProiIPR033027. DSCAM_ver.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF16. PTHR10489:SF16. 2 hits.
PfamiPF00041. fn3. 5 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 8 hits.
SM00408. IGc2. 8 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 8 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WY19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LGHPEPDYRW LKDNMPLELS GRFQKTVTGL LIENIRPSDS GSYVCEVSNR
60 70 80 90 100
YGTAKVIGRL YVKQPLKATI SPRKVKSSVG SQVSLSCSVT GTEDQELSWY
110 120 130 140 150
RNGEILNPGK NVRITGINHE NLIMDHMVKS DGGAYQCFVR KDKLSAQDYV
160 170 180 190 200
QVVLEDGTPK IISAFSEKVV SPAEPVSLMC NVKGTPLPTI TWTLDDDPIL
210 220 230 240 250
KGGSHRISQM ITSEGNVVSY LNISSSQVRD GGVYRCTANN SAGVVLYQAR
260 270 280 290 300
INVRGPASIR PMKNITAIAG RDTYIHCRVI GYPYYSIKWY KNSNLLPFNH
310 320 330 340 350
RQVAFENNGT LKLSDVQKEV DEGEYTCNVL VQPQLSTSQS VHVTVKVPPF
360 370 380 390 400
IQPFEFPRFS IGQRVFIPCV VVSGDLPITI TWQKDGRPIP GSLGVTIDNI
410 420 430 440 450
DFTSSLRISN LSLMHNGNYT CIARNEAAAV EHQSQLIVRV PPKFVVQPRD
460 470 480 490 500
QDGIYGKAVI LNCSAEGYPV PTIVWKFSKG AGVPQFQPIA LNGRIQVLSN
510 520 530 540 550
GSLLIKHVVE EDSGYYLCKV SNDVGADVSK SMYLTVKIPA MITSYPNTTL
560 570 580 590 600
ATQGQKKEMS CTAHGEKPII VRWEKEDRII NPEMARYLVS TKEVGEEVIS
610 620 630 640 650
TLQILPTVRE DSGFFSCHAI NSYGEDRGII QLTVQEPPDP PEIEIKDVKA
660 670 680 690 700
RTITLRWTMG FDGNSPITGY DIECKNKSDS WDSAQRTKDV SPQLNSATII
710 720 730 740 750
DIHPSSTYSI RMYAKNRIGK SEPSNELTIT ADEAAPDGPP QEVHLEPISS
760 770 780 790 800
QSIRVTWKAP KKHLQNGIIR GYQIGYREYS TGGNFQFNII SVDTSGDSEV
810 820 830 840 850
YTLDNLNKFT QYGLVVQACN RAGTGPSSQE IITTTLEDVP SYPPENVQAI
860 870 880 890 900
ATSPESISIS WSTLSKEALN GILQGFRVIY WANLMDGELG EIKNITTTQP
910 920 930 940 950
SLELDGLEKY TNYSIQVLAF TRAGDGVRSE QIFTRTKEDV PGPPAGVKAA
960 970 980 990 1000
AASASMVFVS WLPPLKLNGI IRKYTVFCSH PYPTVISEFE ASPDSFSYRI
1010 1020 1030 1040 1050
PNLSRNRQYS VWVVAVTSAG RGNSSEIITV EPLAKAPARI LTFSGTVTTP
1060 1070 1080 1090 1100
WMKDIVLPCK AVGDPSPAVK WMKDSNGTPS LVTIDGRRSI FSNGSFIIRT
1110 1120 1130 1140 1150
VKAEDSGYYS CIANNNWGSD EIILNLQVQV PPDQPRLTVS KTTSSSITLS
1160 1170 1180 1190 1200
WLPGDNGGSS IRGYILQYSE DNSEQWGSFP ISPSERSYRL ENLKCGTWYK
1210 1220 1230 1240 1250
FTLTAQNGVG PGRISEIIEA KTLGKEPQFS KEQELFASIN TTRVRLNLIG
1260 1270 1280 1290 1300
WNDGGCPITS FTLEYRPFGT TVWTTAQRTS LSKSYILYDL QEATWYELQM
1310 1320 1330 1340 1350
RVCNSAGCAE KQANFATLNY DGSTIPPLIK SVVQNEEGLT TNEGLKMLVT
1360 1370 1380 1390 1400
ISCILVGVLL LFVLLLVVRR RRREQRLKRL RDAKSLAEML MSKNTRTSDT
1410 1420 1430 1440 1450
LSKQQQTLRM HIDIPRAQLL IEERDTMETI DDRSTVLLTD ADFGEAAKQK
1460 1470 1480 1490 1500
SLTVTHTVHY QSVSQATGPL VDVSDARPGT NPTTRRNAKA GPTARNRYAS
1510 1520 1530 1540 1550
QWTLNRPHPT ISAHTLTTDW RLPTPRAAGS VDKESDSYSV SPSQDTDRAR
1560 1570 1580 1590 1600
SSMVSTESAS STYEELARAY EHAKMEEQLR HAKFTITECF ISDTSSEQLT
1610 1620 1630 1640 1650
AGTNEYTDSL TSSTPSESGI CRFTASPPKP QDGGRVMNMA VPKAHRPGGP
1660 1670 1680 1690 1700
GTSRDLSLGQ ACLEPQKSRT LKRPTVLEPI PMEAASSASS TREGQSWQPG
1710 1720 1730 1740
AVATLPQREG AELGQAAKMS SSQESLLDSR GHLKGNNPYA KSYTLV
Length:1,746
Mass (Da):192,496
Last modified:March 1, 2002 - v1
Checksum:iABB8BB9B86AECC32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042090 Genomic DNA. No translation available.
AF042091 Genomic DNA. No translation available.
AF064862 Genomic DNA. No translation available.
AF064863 Genomic DNA. No translation available.
AF064865 Genomic DNA. No translation available.
KF457309 Genomic DNA. No translation available.
KF457311 Genomic DNA. No translation available.
KF457321 Genomic DNA. No translation available.
AF289030 mRNA. Translation: AAL56711.1.
RefSeqiNP_001258463.1. NM_001271534.1.
UniGeneiHs.397800.

Genome annotation databases

EnsembliENST00000404019; ENSP00000385342; ENSG00000171587.
GeneIDi1826.
UCSCiuc062agq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042090 Genomic DNA. No translation available.
AF042091 Genomic DNA. No translation available.
AF064862 Genomic DNA. No translation available.
AF064863 Genomic DNA. No translation available.
AF064865 Genomic DNA. No translation available.
KF457309 Genomic DNA. No translation available.
KF457311 Genomic DNA. No translation available.
KF457321 Genomic DNA. No translation available.
AF289030 mRNA. Translation: AAL56711.1.
RefSeqiNP_001258463.1. NM_001271534.1.
UniGeneiHs.397800.

3D structure databases

ProteinModelPortaliQ8WY19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000383303.

Proteomic databases

PeptideAtlasiQ8WY19.
PRIDEiQ8WY19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404019; ENSP00000385342; ENSG00000171587.
GeneIDi1826.
UCSCiuc062agq.1. human.

Organism-specific databases

CTDi1826.
HGNCiHGNC:3039. DSCAM.
OpenTargetsiENSG00000171587.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJM. Eukaryota.
ENOG410XQX7. LUCA.
GeneTreeiENSGT00860000133679.
HOGENOMiHOG000112277.
HOVERGENiHBG051409.

Miscellaneous databases

ChiTaRSiDSCAM. human.
GenomeRNAii1826.

Gene expression databases

BgeeiENSG00000171587.
ExpressionAtlasiQ8WY19. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 14 hits.
InterProiIPR033027. DSCAM_ver.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF16. PTHR10489:SF16. 2 hits.
PfamiPF00041. fn3. 5 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 8 hits.
SM00408. IGc2. 8 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 8 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8WY19_HUMAN
AccessioniPrimary (citable) accession number: Q8WY19
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.