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Q8WY07 (CTR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cationic amino acid transporter 3

Short name=CAT-3
Short name=CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene names
Name:SLC7A3
Synonyms:ATRC3, CAT3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length619 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala. Ref.1

Post-translational modification

N-glycosylated. Ref.1

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Sequence caution

The sequence BAB55118.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 619619Cationic amino acid transporter 3
PRO_0000054266

Regions

Topological domain1 – 3636Cytoplasmic Potential
Transmembrane37 – 5721Helical; Name=1; Potential
Topological domain58 – 614Extracellular Potential
Transmembrane62 – 8221Helical; Name=2; Potential
Topological domain83 – 10725Cytoplasmic Potential
Transmembrane108 – 12821Helical; Name=3; Potential
Topological domain129 – 16234Extracellular Potential
Transmembrane163 – 18321Helical; Name=4; Potential
Topological domain184 – 1918Cytoplasmic Potential
Transmembrane192 – 21221Helical; Name=5; Potential
Topological domain213 – 23321Extracellular Potential
Transmembrane234 – 25421Helical; Name=6; Potential
Topological domain255 – 28531Cytoplasmic Potential
Transmembrane286 – 30621Helical; Name=7; Potential
Topological domain307 – 33529Extracellular Potential
Transmembrane336 – 35621Helical; Name=8; Potential
Topological domain357 – 38226Cytoplasmic Potential
Transmembrane383 – 40321Helical; Name=9; Potential
Topological domain404 – 4063Extracellular Potential
Transmembrane407 – 42721Helical; Name=10; Potential
Topological domain428 – 47548Cytoplasmic Potential
Transmembrane476 – 49621Helical; Name=11; Potential
Topological domain497 – 50610Extracellular Potential
Transmembrane507 – 52721Helical; Name=12; Potential
Topological domain528 – 54013Cytoplasmic Potential
Transmembrane541 – 56121Helical; Name=13; Potential
Topological domain562 – 5698Extracellular Potential
Transmembrane570 – 59021Helical; Name=14; Potential
Topological domain591 – 61929Cytoplasmic Potential

Amino acid modifications

Modified residue6061Phosphothreonine Ref.6
Modified residue6181Phosphoserine Ref.6
Glycosylation2321N-linked (GlcNAc...) Potential

Natural variations

Natural variant3561M → K Found in a renal cell carcinoma sample; somatic mutation. Ref.7
VAR_064754
Natural variant5081L → V. Ref.5
Corresponds to variant rs6525447 [ dbSNP | Ensembl ].
VAR_048154

Experimental info

Sequence conflict1911K → R in AAH33816. Ref.5
Sequence conflict2211E → G in BAC11253. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8WY07 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 211254FA87D43978

FASTA61967,169
        10         20         30         40         50         60 
MPWQAFRRFG QKLVRRRTLE SGMAETRLAR CLSTLDLVAL GVGSTLGAGV YVLAGEVAKD 

        70         80         90        100        110        120 
KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPRSGSAYLY SYVTVGELWA FTTGWNLILS 

       130        140        150        160        170        180 
YVIGTASVAR AWSSAFDNLI GNHISKTLQG SIALHVPHVL AEYPDFFALG LVLLLTGLLA 

       190        200        210        220        230        240 
LGASESALVT KVFTGVNLLV LGFVMISGFV KGDVHNWKLT EEDYELAMAE LNDTYSLGPL 

       250        260        270        280        290        300 
GSGGFVPFGF EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSVCFLAYF 

       310        320        330        340        350        360 
AVSSALTLMM PYYQLQPESP LPEAFLYIGW APARYVVAVG SLCALSTSLL GSMFPMPRVI 

       370        380        390        400        410        420 
YAMAEDGLLF RVLARIHTGT RTPIIATVVS GIIAAFMAFL FKLTDLVDLM SIGTLLAYSL 

       430        440        450        460        470        480 
VSICVLILRY QPDQETKTGE EVELQEEAIT TESEKLTLWG LFFPLNSIPT PLSGQIVYVC 

       490        500        510        520        530        540 
SSLLAVLLTA LCLVLAQWSV PLLSGDLLWT AVVVLLLLLI IGIIVVIWRQ PQSSTPLHFK 

       550        560        570        580        590        600 
VPALPLLPLM SIFVNIYLMM QMTAGTWARF GVWMLIGFAI YFGYGIQHSL EEIKSNQPSR 

       610 
KSRAKTVDLD PGTLYVHSV 

« Hide

References

« Hide 'large scale' references
[1]"Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues."
Vekony N., Wolf S., Boissel J.-P., Gnauert K., Closs E.I.
Biochemistry 40:12387-12394(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY.
Tissue: Teratocarcinoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-508.
Tissue: Lung.
[6]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-606 AND SER-618, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. expand/collapse author list , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LYS-356.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF320612 mRNA. Translation: AAL37184.1.
AK027447 mRNA. Translation: BAB55118.1. Different initiation.
AK074865 mRNA. Translation: BAC11253.1.
AK075014 mRNA. Translation: BAC11353.1.
AL627071 Genomic DNA. Translation: CAI40156.1.
CH471132 Genomic DNA. Translation: EAX05329.1.
CH471132 Genomic DNA. Translation: EAX05330.1.
BC033816 mRNA. Translation: AAH33816.1.
RefSeqNP_001041629.1. NM_001048164.2.
NP_116192.4. NM_032803.5.
UniGeneHs.175220.

3D structure databases

ProteinModelPortalQ8WY07.
SMRQ8WY07. Positions 32-428.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124329. 1 interaction.
STRING9606.ENSP00000298085.

Chemistry

DrugBankDB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Protein family/group databases

TCDB2.A.3.3.10. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteQ8WY07.

Polymorphism databases

DMDM41016908.

Proteomic databases

PaxDbQ8WY07.
PRIDEQ8WY07.

Protocols and materials databases

DNASU84889.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298085; ENSP00000298085; ENSG00000165349.
ENST00000374299; ENSP00000363417; ENSG00000165349.
GeneID84889.
KEGGhsa:84889.
UCSCuc004dyn.3. human.

Organism-specific databases

CTD84889.
GeneCardsGC0XM070145.
HGNCHGNC:11061. SLC7A3.
HPAHPA003629.
MIM300443. gene.
neXtProtNX_Q8WY07.
PharmGKBPA35921.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0531.
HOGENOMHOG000250623.
HOVERGENHBG000280.
InParanoidQ8WY07.
KOK13865.
OMASAYSWIS.
OrthoDBEOG72C501.
PhylomeDBQ8WY07.
TreeFamTF315212.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.

Gene expression databases

BgeeQ8WY07.
CleanExHS_SLC7A3.
GenevestigatorQ8WY07.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00906. 2A0303. 1 hit.
ProtoNetSearch...

Other

GeneWikiSLC7A3.
GenomeRNAi84889.
NextBio75212.
PROQ8WY07.
SOURCESearch...

Entry information

Entry nameCTR3_HUMAN
AccessionPrimary (citable) accession number: Q8WY07
Secondary accession number(s): D3DVU7 expand/collapse secondary AC list , Q5JQR2, Q8N185, Q8NCA7, Q96SZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM