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Protein

Cationic amino acid transporter 3

Gene

SLC7A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

GO - Molecular functioni

  1. arginine transmembrane transporter activity Source: Ensembl
  2. L-lysine transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. ion transport Source: Reactome
  3. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.3.10. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 3
Short name:
CAT-3
Short name:
CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene namesi
Name:SLC7A3
Synonyms:ATRC3, CAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:11061. SLC7A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini58 – 614ExtracellularSequence Analysis
Transmembranei62 – 8221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini83 – 10725CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 16234ExtracellularSequence AnalysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini184 – 1918CytoplasmicSequence Analysis
Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini213 – 23321ExtracellularSequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini255 – 28531CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini307 – 33529ExtracellularSequence AnalysisAdd
BLAST
Transmembranei336 – 35621Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini357 – 38226CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei383 – 40321Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini404 – 4063ExtracellularSequence Analysis
Transmembranei407 – 42721Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini428 – 47548CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei476 – 49621Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini497 – 50610ExtracellularSequence Analysis
Transmembranei507 – 52721Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini528 – 54013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei541 – 56121Helical; Name=13Sequence AnalysisAdd
BLAST
Topological domaini562 – 5698ExtracellularSequence Analysis
Transmembranei570 – 59021Helical; Name=14Sequence AnalysisAdd
BLAST
Topological domaini591 – 61929CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Cationic amino acid transporter 3PRO_0000054266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
Modified residuei606 – 6061Phosphothreonine1 Publication
Modified residuei618 – 6181Phosphoserine1 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8WY07.
PRIDEiQ8WY07.

PTM databases

PhosphoSiteiQ8WY07.

Expressioni

Tissue specificityi

Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala.1 Publication

Gene expression databases

BgeeiQ8WY07.
CleanExiHS_SLC7A3.
GenevestigatoriQ8WY07.

Organism-specific databases

HPAiHPA003629.

Interactioni

Protein-protein interaction databases

BioGridi124329. 5 interactions.
STRINGi9606.ENSP00000298085.

Structurei

3D structure databases

ProteinModelPortaliQ8WY07.
SMRiQ8WY07. Positions 32-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiQ8WY07.
KOiK13865.
OMAiGWASYFN.
OrthoDBiEOG72C501.
PhylomeDBiQ8WY07.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PTHR11785:SF209. PTHR11785:SF209. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WY07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPWQAFRRFG QKLVRRRTLE SGMAETRLAR CLSTLDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPRSGSAYLY
110 120 130 140 150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISKTLQG
160 170 180 190 200
SIALHVPHVL AEYPDFFALG LVLLLTGLLA LGASESALVT KVFTGVNLLV
210 220 230 240 250
LGFVMISGFV KGDVHNWKLT EEDYELAMAE LNDTYSLGPL GSGGFVPFGF
260 270 280 290 300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSVCFLAYF
310 320 330 340 350
AVSSALTLMM PYYQLQPESP LPEAFLYIGW APARYVVAVG SLCALSTSLL
360 370 380 390 400
GSMFPMPRVI YAMAEDGLLF RVLARIHTGT RTPIIATVVS GIIAAFMAFL
410 420 430 440 450
FKLTDLVDLM SIGTLLAYSL VSICVLILRY QPDQETKTGE EVELQEEAIT
460 470 480 490 500
TESEKLTLWG LFFPLNSIPT PLSGQIVYVC SSLLAVLLTA LCLVLAQWSV
510 520 530 540 550
PLLSGDLLWT AVVVLLLLLI IGIIVVIWRQ PQSSTPLHFK VPALPLLPLM
560 570 580 590 600
SIFVNIYLMM QMTAGTWARF GVWMLIGFAI YFGYGIQHSL EEIKSNQPSR
610
KSRAKTVDLD PGTLYVHSV
Length:619
Mass (Da):67,169
Last modified:March 1, 2002 - v1
Checksum:i211254FA87D43978
GO

Sequence cautioni

The sequence BAB55118.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911K → R in AAH33816. (PubMed:15489334)Curated
Sequence conflicti221 – 2211E → G in BAC11253. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti356 – 3561M → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064754
Natural varianti508 – 5081L → V.1 Publication
Corresponds to variant rs6525447 [ dbSNP | Ensembl ].
VAR_048154

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320612 mRNA. Translation: AAL37184.1.
AK027447 mRNA. Translation: BAB55118.1. Different initiation.
AK074865 mRNA. Translation: BAC11253.1.
AK075014 mRNA. Translation: BAC11353.1.
AL627071 Genomic DNA. Translation: CAI40156.1.
CH471132 Genomic DNA. Translation: EAX05329.1.
CH471132 Genomic DNA. Translation: EAX05330.1.
BC033816 mRNA. Translation: AAH33816.1.
CCDSiCCDS14404.1.
RefSeqiNP_001041629.1. NM_001048164.2.
NP_116192.4. NM_032803.5.
UniGeneiHs.175220.

Genome annotation databases

EnsembliENST00000298085; ENSP00000298085; ENSG00000165349.
ENST00000374299; ENSP00000363417; ENSG00000165349.
GeneIDi84889.
KEGGihsa:84889.
UCSCiuc004dyn.3. human.

Polymorphism databases

DMDMi41016908.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320612 mRNA. Translation: AAL37184.1.
AK027447 mRNA. Translation: BAB55118.1. Different initiation.
AK074865 mRNA. Translation: BAC11253.1.
AK075014 mRNA. Translation: BAC11353.1.
AL627071 Genomic DNA. Translation: CAI40156.1.
CH471132 Genomic DNA. Translation: EAX05329.1.
CH471132 Genomic DNA. Translation: EAX05330.1.
BC033816 mRNA. Translation: AAH33816.1.
CCDSiCCDS14404.1.
RefSeqiNP_001041629.1. NM_001048164.2.
NP_116192.4. NM_032803.5.
UniGeneiHs.175220.

3D structure databases

ProteinModelPortaliQ8WY07.
SMRiQ8WY07. Positions 32-428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124329. 5 interactions.
STRINGi9606.ENSP00000298085.

Chemistry

DrugBankiDB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Protein family/group databases

TCDBi2.A.3.3.10. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteiQ8WY07.

Polymorphism databases

DMDMi41016908.

Proteomic databases

PaxDbiQ8WY07.
PRIDEiQ8WY07.

Protocols and materials databases

DNASUi84889.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298085; ENSP00000298085; ENSG00000165349.
ENST00000374299; ENSP00000363417; ENSG00000165349.
GeneIDi84889.
KEGGihsa:84889.
UCSCiuc004dyn.3. human.

Organism-specific databases

CTDi84889.
GeneCardsiGC0XM070145.
HGNCiHGNC:11061. SLC7A3.
HPAiHPA003629.
MIMi300443. gene.
neXtProtiNX_Q8WY07.
PharmGKBiPA35921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiQ8WY07.
KOiK13865.
OMAiGWASYFN.
OrthoDBiEOG72C501.
PhylomeDBiQ8WY07.
TreeFamiTF315212.

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

GeneWikiiSLC7A3.
GenomeRNAii84889.
NextBioi75212.
PROiQ8WY07.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WY07.
CleanExiHS_SLC7A3.
GenevestigatoriQ8WY07.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PTHR11785:SF209. PTHR11785:SF209. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues."
    Vekony N., Wolf S., Boissel J.-P., Gnauert K., Closs E.I.
    Biochemistry 40:12387-12394(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY.
    Tissue: Teratocarcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-508.
    Tissue: Lung.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-606 AND SER-618, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: VARIANT LYS-356.

Entry informationi

Entry nameiCTR3_HUMAN
AccessioniPrimary (citable) accession number: Q8WY07
Secondary accession number(s): D3DVU7
, Q5JQR2, Q8N185, Q8NCA7, Q96SZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.