Q8WY07 (CTR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cationic amino acid transporter 3
Short name=CAT-3
Short name=CAT3

Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3

Gene names

Name:	SLC7A3
Synonyms:	ATRC3, CAT3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	619 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Ref.1
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala. Ref.1
Post-translational modification	N-glycosylated. Ref.1
Sequence similarities	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]
Sequence caution	The sequence BAB55118.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lysine transport Inferred from electronic annotation. Source: GOC transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	L-lysine transmembrane transporter activity Inferred from electronic annotation. Source: Compara arginine transmembrane transporter activity Inferred from electronic annotation. Source: Compara cationic amino acid transmembrane transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 619	619	Cationic amino acid transporter 3		PRO_0000054266
Regions
	Topological domain	1 – 36	36	Cytoplasmic Potential
	Transmembrane	37 – 57	21	Helical; Name=1; Potential
	Topological domain	58 – 61	4	Extracellular Potential
	Transmembrane	62 – 82	21	Helical; Name=2; Potential
	Topological domain	83 – 107	25	Cytoplasmic Potential
	Transmembrane	108 – 128	21	Helical; Name=3; Potential
	Topological domain	129 – 162	34	Extracellular Potential
	Transmembrane	163 – 183	21	Helical; Name=4; Potential
	Topological domain	184 – 191	8	Cytoplasmic Potential
	Transmembrane	192 – 212	21	Helical; Name=5; Potential
	Topological domain	213 – 233	21	Extracellular Potential
	Transmembrane	234 – 254	21	Helical; Name=6; Potential
	Topological domain	255 – 285	31	Cytoplasmic Potential
	Transmembrane	286 – 306	21	Helical; Name=7; Potential
	Topological domain	307 – 335	29	Extracellular Potential
	Transmembrane	336 – 356	21	Helical; Name=8; Potential
	Topological domain	357 – 382	26	Cytoplasmic Potential
	Transmembrane	383 – 403	21	Helical; Name=9; Potential
	Topological domain	404 – 406	3	Extracellular Potential
	Transmembrane	407 – 427	21	Helical; Name=10; Potential
	Topological domain	428 – 475	48	Cytoplasmic Potential
	Transmembrane	476 – 496	21	Helical; Name=11; Potential
	Topological domain	497 – 506	10	Extracellular Potential
	Transmembrane	507 – 527	21	Helical; Name=12; Potential
	Topological domain	528 – 540	13	Cytoplasmic Potential
	Transmembrane	541 – 561	21	Helical; Name=13; Potential
	Topological domain	562 – 569	8	Extracellular Potential
	Transmembrane	570 – 590	21	Helical; Name=14; Potential
	Topological domain	591 – 619	29	Cytoplasmic Potential
Amino acid modifications
	Modified residue	606	1	Phosphothreonine Ref.6
	Modified residue	618	1	Phosphoserine Ref.6
	Glycosylation	232	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	356	1	M → K Found in a renal cell carcinoma sample; somatic mutation. Ref.7		VAR_064754
	Natural variant	508	1	L → V. Ref.5 Corresponds to variant rs6525447 [ dbSNP | Ensembl ].		VAR_048154
Experimental info
	Sequence conflict	191	1	K → R in AAH33816. Ref.5
	Sequence conflict	221	1	E → G in BAC11253. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8WY07 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 211254FA87D43978	FASTA	619	67,169
	10 20 30 40 50 60 MPWQAFRRFG QKLVRRRTLE SGMAETRLAR CLSTLDLVAL GVGSTLGAGV YVLAGEVAKD 70 80 90 100 110 120 KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPRSGSAYLY SYVTVGELWA FTTGWNLILS 130 140 150 160 170 180 YVIGTASVAR AWSSAFDNLI GNHISKTLQG SIALHVPHVL AEYPDFFALG LVLLLTGLLA 190 200 210 220 230 240 LGASESALVT KVFTGVNLLV LGFVMISGFV KGDVHNWKLT EEDYELAMAE LNDTYSLGPL 250 260 270 280 290 300 GSGGFVPFGF EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSVCFLAYF 310 320 330 340 350 360 AVSSALTLMM PYYQLQPESP LPEAFLYIGW APARYVVAVG SLCALSTSLL GSMFPMPRVI 370 380 390 400 410 420 YAMAEDGLLF RVLARIHTGT RTPIIATVVS GIIAAFMAFL FKLTDLVDLM SIGTLLAYSL 430 440 450 460 470 480 VSICVLILRY QPDQETKTGE EVELQEEAIT TESEKLTLWG LFFPLNSIPT PLSGQIVYVC 490 500 510 520 530 540 SSLLAVLLTA LCLVLAQWSV PLLSGDLLWT AVVVLLLLLI IGIIVVIWRQ PQSSTPLHFK 550 560 570 580 590 600 VPALPLLPLM SIFVNIYLMM QMTAGTWARF GVWMLIGFAI YFGYGIQHSL EEIKSNQPSR 610 KSRAKTVDLD PGTLYVHSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues." Vekony N., Wolf S., Boissel J.-P., Gnauert K., Closs E.I. Biochemistry 40:12387-12394(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY. Tissue: Teratocarcinoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-508. Tissue: Lung.
[6]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-606 AND SER-618, MASS SPECTROMETRY.
[7]	"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A. Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LYS-356.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF320612 mRNA. Translation: AAL37184.1. AK027447 mRNA. Translation: BAB55118.1. Different initiation. AK074865 mRNA. Translation: BAC11253.1. AK075014 mRNA. Translation: BAC11353.1. AL627071 Genomic DNA. Translation: CAI40156.1. CH471132 Genomic DNA. Translation: EAX05329.1. CH471132 Genomic DNA. Translation: EAX05330.1. BC033816 mRNA. Translation: AAH33816.1.
IPI	IPI00295698.
RefSeq	NP_001041629.1. NM_001048164.2. NP_116192.4. NM_032803.5.
UniGene	Hs.175220.
3D structure databases
ProteinModelPortal	Q8WY07.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298085.
PTM databases
PhosphoSite	Q8WY07.
Polymorphism databases
DMDM	41016908.
Proteomic databases
PaxDb	Q8WY07.
PRIDE	Q8WY07.
Protocols and materials databases
DNASU	84889.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298085; ENSP00000298085; ENSG00000165349. ENST00000374299; ENSP00000363417; ENSG00000165349.
GeneID	84889.
KEGG	hsa:84889.
UCSC	uc004dyn.3. human.
Organism-specific databases
CTD	84889.
GeneCards	GC0XM070062.
HGNC	HGNC:11061. SLC7A3.
HPA	HPA003629.
MIM	300443. gene.
neXtProt	NX_Q8WY07.
PharmGKB	PA35921.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0531.
HOGENOM	HOG000250623.
HOVERGEN	HBG000280.
InParanoid	Q8WY07.
KO	K13865.
OMA	NQPSRKS.
OrthoDB	EOG45DWP8.
PhylomeDB	Q8WY07.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_19419. Amino acid and oligopeptide SLC transporters.
Gene expression databases
Bgee	Q8WY07.
CleanEx	HS_SLC7A3.
Genevestigator	Q8WY07.
GermOnline	ENSG00000165349. Homo sapiens.
Family and domain databases
InterPro	IPR002293. AA/rel_permease1. IPR015606. Cat-AATrans. IPR004755. Cat_AA_permease. [Graphical view]
PANTHER	PTHR11785. PTHR11785. 1 hit. PTHR11785:SF53. PTHR11785:SF53. 1 hit.
PIRSF	PIRSF006060. AA_transporter. 1 hit.
TIGRFAMs	TIGR00906. 2A0303. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00125. L-Arginine. DB00123. L-Lysine. DB00129. L-Ornithine.
GenomeRNAi	84889.
NextBio	75212.
SOURCE	Search...

Entry information

Entry name

CTR3_HUMAN

Accession

Primary (citable) accession number: Q8WY07
Secondary accession number(s): D3DVU7 , Q5JQR2, Q8N185, Q8NCA7, Q96SZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	March 1, 2002
Last modified:	April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.