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Protein

Cationic amino acid transporter 3

Gene

SLC7A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165349-MONOMER.
ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.3.10. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 3
Short name:
CAT-3
Short name:
CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene namesi
Name:SLC7A3
Synonyms:ATRC3, CAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11061. SLC7A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 107CytoplasmicSequence analysisAdd BLAST25
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 162ExtracellularSequence analysisAdd BLAST34
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 233ExtracellularSequence analysisAdd BLAST21
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 285CytoplasmicSequence analysisAdd BLAST31
Transmembranei286 – 306Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini307 – 335ExtracellularSequence analysisAdd BLAST29
Transmembranei336 – 356Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini357 – 382CytoplasmicSequence analysisAdd BLAST26
Transmembranei383 – 403Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini404 – 406ExtracellularSequence analysis3
Transmembranei407 – 427Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini428 – 475CytoplasmicSequence analysisAdd BLAST48
Transmembranei476 – 496Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini497 – 506ExtracellularSequence analysis10
Transmembranei507 – 527Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini528 – 540CytoplasmicSequence analysisAdd BLAST13
Transmembranei541 – 561Helical; Name=13Sequence analysisAdd BLAST21
Topological domaini562 – 569ExtracellularSequence analysis8
Transmembranei570 – 590Helical; Name=14Sequence analysisAdd BLAST21
Topological domaini591 – 619CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84889.
OpenTargetsiENSG00000165349.
PharmGKBiPA35921.

Chemistry databases

DrugBankiDB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Polymorphism and mutation databases

BioMutaiSLC7A3.
DMDMi41016908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542661 – 619Cationic amino acid transporter 3Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Modified residuei606PhosphothreonineCombined sources1
Modified residuei618PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8WY07.
PaxDbiQ8WY07.
PeptideAtlasiQ8WY07.
PRIDEiQ8WY07.

PTM databases

iPTMnetiQ8WY07.
PhosphoSitePlusiQ8WY07.

Expressioni

Tissue specificityi

Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala.1 Publication

Gene expression databases

BgeeiENSG00000165349.
CleanExiHS_SLC7A3.
GenevisibleiQ8WY07. HS.

Organism-specific databases

HPAiHPA003629.

Interactioni

Protein-protein interaction databases

BioGridi124329. 14 interactors.
STRINGi9606.ENSP00000298085.

Structurei

3D structure databases

ProteinModelPortaliQ8WY07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiQ8WY07.
KOiK13865.
OMAiYTGWAPA.
OrthoDBiEOG091G05NM.
PhylomeDBiQ8WY07.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PTHR11785:SF209. PTHR11785:SF209. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WY07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWQAFRRFG QKLVRRRTLE SGMAETRLAR CLSTLDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPRSGSAYLY
110 120 130 140 150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISKTLQG
160 170 180 190 200
SIALHVPHVL AEYPDFFALG LVLLLTGLLA LGASESALVT KVFTGVNLLV
210 220 230 240 250
LGFVMISGFV KGDVHNWKLT EEDYELAMAE LNDTYSLGPL GSGGFVPFGF
260 270 280 290 300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSVCFLAYF
310 320 330 340 350
AVSSALTLMM PYYQLQPESP LPEAFLYIGW APARYVVAVG SLCALSTSLL
360 370 380 390 400
GSMFPMPRVI YAMAEDGLLF RVLARIHTGT RTPIIATVVS GIIAAFMAFL
410 420 430 440 450
FKLTDLVDLM SIGTLLAYSL VSICVLILRY QPDQETKTGE EVELQEEAIT
460 470 480 490 500
TESEKLTLWG LFFPLNSIPT PLSGQIVYVC SSLLAVLLTA LCLVLAQWSV
510 520 530 540 550
PLLSGDLLWT AVVVLLLLLI IGIIVVIWRQ PQSSTPLHFK VPALPLLPLM
560 570 580 590 600
SIFVNIYLMM QMTAGTWARF GVWMLIGFAI YFGYGIQHSL EEIKSNQPSR
610
KSRAKTVDLD PGTLYVHSV
Length:619
Mass (Da):67,169
Last modified:March 1, 2002 - v1
Checksum:i211254FA87D43978
GO

Sequence cautioni

The sequence BAB55118 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191K → R in AAH33816 (PubMed:15489334).Curated1
Sequence conflicti221E → G in BAC11253 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064754356M → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_048154508L → V.1 PublicationCorresponds to variant rs6525447dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320612 mRNA. Translation: AAL37184.1.
AK027447 mRNA. Translation: BAB55118.1. Different initiation.
AK074865 mRNA. Translation: BAC11253.1.
AK075014 mRNA. Translation: BAC11353.1.
AL627071 Genomic DNA. Translation: CAI40156.1.
CH471132 Genomic DNA. Translation: EAX05329.1.
CH471132 Genomic DNA. Translation: EAX05330.1.
BC033816 mRNA. Translation: AAH33816.1.
CCDSiCCDS14404.1.
RefSeqiNP_001041629.1. NM_001048164.2.
NP_116192.4. NM_032803.5.
XP_016885401.1. XM_017029912.1.
UniGeneiHs.175220.

Genome annotation databases

EnsembliENST00000298085; ENSP00000298085; ENSG00000165349.
ENST00000374299; ENSP00000363417; ENSG00000165349.
GeneIDi84889.
KEGGihsa:84889.
UCSCiuc004dyn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320612 mRNA. Translation: AAL37184.1.
AK027447 mRNA. Translation: BAB55118.1. Different initiation.
AK074865 mRNA. Translation: BAC11253.1.
AK075014 mRNA. Translation: BAC11353.1.
AL627071 Genomic DNA. Translation: CAI40156.1.
CH471132 Genomic DNA. Translation: EAX05329.1.
CH471132 Genomic DNA. Translation: EAX05330.1.
BC033816 mRNA. Translation: AAH33816.1.
CCDSiCCDS14404.1.
RefSeqiNP_001041629.1. NM_001048164.2.
NP_116192.4. NM_032803.5.
XP_016885401.1. XM_017029912.1.
UniGeneiHs.175220.

3D structure databases

ProteinModelPortaliQ8WY07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124329. 14 interactors.
STRINGi9606.ENSP00000298085.

Chemistry databases

DrugBankiDB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Protein family/group databases

TCDBi2.A.3.3.10. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiQ8WY07.
PhosphoSitePlusiQ8WY07.

Polymorphism and mutation databases

BioMutaiSLC7A3.
DMDMi41016908.

Proteomic databases

EPDiQ8WY07.
PaxDbiQ8WY07.
PeptideAtlasiQ8WY07.
PRIDEiQ8WY07.

Protocols and materials databases

DNASUi84889.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298085; ENSP00000298085; ENSG00000165349.
ENST00000374299; ENSP00000363417; ENSG00000165349.
GeneIDi84889.
KEGGihsa:84889.
UCSCiuc004dyn.4. human.

Organism-specific databases

CTDi84889.
DisGeNETi84889.
GeneCardsiSLC7A3.
HGNCiHGNC:11061. SLC7A3.
HPAiHPA003629.
MIMi300443. gene.
neXtProtiNX_Q8WY07.
OpenTargetsiENSG00000165349.
PharmGKBiPA35921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiQ8WY07.
KOiK13865.
OMAiYTGWAPA.
OrthoDBiEOG091G05NM.
PhylomeDBiQ8WY07.
TreeFamiTF315212.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165349-MONOMER.
ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

GeneWikiiSLC7A3.
GenomeRNAii84889.
PROiQ8WY07.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165349.
CleanExiHS_SLC7A3.
GenevisibleiQ8WY07. HS.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PTHR11785:SF209. PTHR11785:SF209. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCTR3_HUMAN
AccessioniPrimary (citable) accession number: Q8WY07
Secondary accession number(s): D3DVU7
, Q5JQR2, Q8N185, Q8NCA7, Q96SZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.