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Protein

DnaJ homolog subfamily C member 9

Gene

DNAJC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.1 Publication

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

GO - Biological processi

  • positive regulation of ATPase activity Source: UniProtKB
  • social behavior Source: UniProtKB

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 9
Short name:
HDJC91 Publication
Alternative name(s):
DnaJ protein SB73
Gene namesi
Name:DNAJC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000213551.4
HGNCiHGNC:19123 DNAJC9
MIMi611206 gene
neXtProtiNX_Q8WXX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23234
OpenTargetsiENSG00000213551
PharmGKBiPA38797

Polymorphism and mutation databases

BioMutaiDNAJC9
DMDMi52782787

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710631 – 260DnaJ homolog subfamily C member 9Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WXX5
MaxQBiQ8WXX5
PaxDbiQ8WXX5
PeptideAtlasiQ8WXX5
PRIDEiQ8WXX5

PTM databases

iPTMnetiQ8WXX5
PhosphoSitePlusiQ8WXX5

Expressioni

Tissue specificityi

Expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, thymus, ovary, colon and peripheral blood.1 Publication

Inductioni

By heat shock, bacterial lipopolysaccharides (LPS), phorbol 12-myristate 13-acetate (PMA), and the cytokine TNF (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000213551
CleanExiHS_DNAJC9
ExpressionAtlasiQ8WXX5 baseline and differential
GenevisibleiQ8WXX5 HS

Organism-specific databases

HPAiHPA035215
HPA035216

Interactioni

Subunit structurei

Interacts (via J domain) with HSPA1A, HSPA1B and HSPA8.1 Publication

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi11683941 interactors.
IntActiQ8WXX5 23 interactors.
MINTiQ8WXX5
STRINGi9606.ENSP00000362041

Structurei

3D structure databases

ProteinModelPortaliQ8WXX5
SMRiQ8WXX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 82JPROSITE-ProRule annotationAdd BLAST68

Phylogenomic databases

eggNOGiKOG0719 Eukaryota
COG2214 LUCA
GeneTreeiENSGT00390000014549
HOGENOMiHOG000165297
HOVERGENiHBG051378
InParanoidiQ8WXX5
KOiK09529
OMAiRHQKYAR
OrthoDBiEOG091G0MMY
PhylomeDBiQ8WXX5
TreeFamiTF105168

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.1101 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WXX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLDLCEEV FGTADLYRVL GVRREASDGE VRRGYHKVSL QVHPDRVGEG
60 70 80 90 100
DKEDATRRFQ ILGKVYSVLS DREQRAVYDE QGTVDEDSPV LTQDRDWEAY
110 120 130 140 150
WRLLFKKISL EDIQAFEKTY KGSEEELADI KQAYLDFKGD MDQIMESVLC
160 170 180 190 200
VQYTEEPRIR NIIQQAIDAG EVPSYNAFVK ESKQKMNARK RRAQEEAKEA
210 220 230 240 250
EMSRKELGLD EGVDSLKAAI QSRQKDRQKE MDNFLAQMEA KYCKSSKGGG
260
KKSALKKEKK
Length:260
Mass (Da):29,910
Last modified:March 1, 2002 - v1
Checksum:i6C5C34774217863F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327347 mRNA Translation: AAL56008.1
AK074420 mRNA Translation: BAB85076.1
AK094162 mRNA Translation: BAG52832.1
CH471083 Genomic DNA Translation: EAW54483.1
BC136507 mRNA Translation: AAI36508.1
CCDSiCCDS7322.1
RefSeqiNP_056005.1, NM_015190.4
UniGeneiHs.408577
Hs.731648
Hs.732485

Genome annotation databases

EnsembliENST00000372950; ENSP00000362041; ENSG00000213551
GeneIDi23234
KEGGihsa:23234
UCSCiuc010qkg.2 human

Similar proteinsi

Entry informationi

Entry nameiDNJC9_HUMAN
AccessioniPrimary (citable) accession number: Q8WXX5
Secondary accession number(s): B2RMW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome