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Protein

DnaJ homolog subfamily C member 9

Gene

DNAJC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.1 Publication

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

GO - Biological processi

  • positive regulation of ATPase activity Source: UniProtKB
  • social behavior Source: UniProtKB

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 9
Short name:
HDJC91 Publication
Alternative name(s):
DnaJ protein SB73
Gene namesi
Name:DNAJC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000213551.4.
HGNCiHGNC:19123. DNAJC9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23234.
OpenTargetsiENSG00000213551.
PharmGKBiPA38797.

Polymorphism and mutation databases

BioMutaiDNAJC9.
DMDMi52782787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710631 – 260DnaJ homolog subfamily C member 9Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WXX5.
MaxQBiQ8WXX5.
PaxDbiQ8WXX5.
PeptideAtlasiQ8WXX5.
PRIDEiQ8WXX5.

PTM databases

iPTMnetiQ8WXX5.
PhosphoSitePlusiQ8WXX5.

Expressioni

Tissue specificityi

Expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, thymus, ovary, colon and peripheral blood.1 Publication

Inductioni

By heat shock, bacterial lipopolysaccharides (LPS), phorbol 12-myristate 13-acetate (PMA), and the cytokine TNF (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000213551.
CleanExiHS_DNAJC9.
ExpressionAtlasiQ8WXX5. baseline and differential.
GenevisibleiQ8WXX5. HS.

Organism-specific databases

HPAiHPA035215.
HPA035216.

Interactioni

Subunit structurei

Interacts (via J domain) with HSPA1A, HSPA1B and HSPA8.1 Publication

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116839. 38 interactors.
IntActiQ8WXX5. 17 interactors.
MINTiMINT-3047919.
STRINGi9606.ENSP00000362041.

Structurei

3D structure databases

ProteinModelPortaliQ8WXX5.
SMRiQ8WXX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 82JPROSITE-ProRule annotationAdd BLAST68

Phylogenomic databases

eggNOGiKOG0719. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00390000014549.
HOGENOMiHOG000165297.
HOVERGENiHBG051378.
InParanoidiQ8WXX5.
KOiK09529.
OMAiRHQKYAR.
OrthoDBiEOG091G0MMY.
PhylomeDBiQ8WXX5.
TreeFamiTF105168.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR036869. DnaJ_dom_sf.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiView protein in PROSITE
PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WXX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLDLCEEV FGTADLYRVL GVRREASDGE VRRGYHKVSL QVHPDRVGEG
60 70 80 90 100
DKEDATRRFQ ILGKVYSVLS DREQRAVYDE QGTVDEDSPV LTQDRDWEAY
110 120 130 140 150
WRLLFKKISL EDIQAFEKTY KGSEEELADI KQAYLDFKGD MDQIMESVLC
160 170 180 190 200
VQYTEEPRIR NIIQQAIDAG EVPSYNAFVK ESKQKMNARK RRAQEEAKEA
210 220 230 240 250
EMSRKELGLD EGVDSLKAAI QSRQKDRQKE MDNFLAQMEA KYCKSSKGGG
260
KKSALKKEKK
Length:260
Mass (Da):29,910
Last modified:March 1, 2002 - v1
Checksum:i6C5C34774217863F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327347 mRNA. Translation: AAL56008.1.
AK074420 mRNA. Translation: BAB85076.1.
AK094162 mRNA. Translation: BAG52832.1.
CH471083 Genomic DNA. Translation: EAW54483.1.
BC136507 mRNA. Translation: AAI36508.1.
CCDSiCCDS7322.1.
RefSeqiNP_056005.1. NM_015190.4.
UniGeneiHs.408577.
Hs.731648.
Hs.732485.

Genome annotation databases

EnsembliENST00000372950; ENSP00000362041; ENSG00000213551.
GeneIDi23234.
KEGGihsa:23234.
UCSCiuc010qkg.2. human.

Similar proteinsi

Entry informationi

Entry nameiDNJC9_HUMAN
AccessioniPrimary (citable) accession number: Q8WXX5
Secondary accession number(s): B2RMW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot