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Q8WXW3

- PIBF1_HUMAN

UniProt

Q8WXW3 - PIBF1_HUMAN

Protein

Progesterone-induced-blocking factor 1

Gene

PIBF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Progesterone-induced-blocking factor 1
    Gene namesi
    Name:PIBF1
    Synonyms:C13orf24, PIBF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:23352. PIBF1.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162399421.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 757757Progesterone-induced-blocking factor 1PRO_0000058426Add
    BLAST

    Proteomic databases

    MaxQBiQ8WXW3.
    PaxDbiQ8WXW3.
    PRIDEiQ8WXW3.

    PTM databases

    PhosphoSiteiQ8WXW3.

    Expressioni

    Tissue specificityi

    Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon.1 Publication

    Inductioni

    By progesterone.

    Gene expression databases

    BgeeiQ8WXW3.
    CleanExiHS_PIBF1.
    GenevestigatoriQ8WXW3.

    Organism-specific databases

    HPAiHPA052269.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HTTP428583EBI-2558770,EBI-466029

    Protein-protein interaction databases

    BioGridi115727. 5 interactions.
    IntActiQ8WXW3. 7 interactions.
    STRINGi9606.ENSP00000317144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG116399.
    HOGENOMiHOG000006812.
    HOVERGENiHBG053599.
    InParanoidiQ8WXW3.
    KOiK16538.
    OMAiEYENKLH.
    OrthoDBiEOG7B8S3C.
    PhylomeDBiQ8WXW3.
    TreeFamiTF329068.

    Family and domain databases

    InterProiIPR026205. PIBF1.
    [Graphical view]
    PANTHERiPTHR18950. PTHR18950. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WXW3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRKISKESK KVNISSSLES EDISLETTVP TDDISSSEER EGKVRITRQL    50
    IERKELLHNI QLLKIELSQK TMMIDNLKVD YLTKIEELEE KLNDALHQKQ 100
    LLTLRLDNQL AFQQKDASKY QELMKQEMET ILLRQKQLEE TNLQLREKAG 150
    DVRRNLRDFE LTEEQYIKLK AFPEDQLSIP EYVSVRFYEL VNPLRKEICE 200
    LQVKKNILAE ELSTNKNQLK QLTETYEEDR KNYSEVQIRC QRLALELADT 250
    KQLIQQGDYR QENYDKVKSE RDALEQEVIE LRRKHEILEA SHMIQTKERS 300
    ELSKEVVTLE QTVTLLQKDK EYLNRQNMEL SVRCAHEEDR LERLQAQLEE 350
    SKKAREEMYE KYVASRDHYK TEYENKLHDE LEQIRLKTNQ EIDQLRNASR 400
    EMYERENRNL REARDNAVAE KERAVMAEKD ALEKHDQLLD RYRELQLSTE 450
    SKVTEFLHQS KLKSFESERV QLLQEETARN LTQCQLECEK YQKKLEVLTK 500
    EFYSLQASSE KRITELQAQN SEHQARLDIY EKLEKELDEI IMQTAEIENE 550
    DEAERVLFSY GYGANVPTTA KRRLKQSVHL ARRVLQLEKQ NSLILKDLEH 600
    RKDQVTQLSQ ELDRANSLLN QTQQPYRYLI ESVRQRDSKI DSLTESIAQL 650
    EKDVSNLNKE KSALLQTKNQ MALDLEQLLN HREELAAMKQ ILVKMHSKHS 700
    ENSLLLTKTE PKHVTENQKS KTLNVPKEHE DNIFTPKPTL FTKKEAPEWS 750
    KKQKMKT 757
    Length:757
    Mass (Da):89,805
    Last modified:August 30, 2005 - v2
    Checksum:iB469FB3BCC7E80FD
    GO
    Isoform 2 (identifier: Q8WXW3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-541: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:216
    Mass (Da):25,125
    Checksum:i83A174B20DF2240F
    GO
    Isoform 3 (identifier: Q8WXW3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         101-103: LLT → QTF
         104-757: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:103
    Mass (Da):12,016
    Checksum:iDBD92AF3CD8037CB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti155 – 1551N → S in CAA70844. 1 PublicationCurated
    Sequence conflicti333 – 3331R → C in CAA70844. 1 PublicationCurated
    Sequence conflicti597 – 61418DLEHR…QELDR → RSGTSKGPSNTAFTRSLTE in AAQ67659. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti610 – 6101Q → P in AAL37481. (PubMed:11935316)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti167 – 1671I → V.
    Corresponds to variant rs1372000 [ dbSNP | Ensembl ].
    VAR_051279
    Natural varianti405 – 4051R → Q.
    Corresponds to variant rs17089782 [ dbSNP | Ensembl ].
    VAR_051280
    Natural varianti630 – 6301I → V.
    Corresponds to variant rs11544631 [ dbSNP | Ensembl ].
    VAR_051281

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 541541Missing in isoform 2. 1 PublicationVSP_015302Add
    BLAST
    Alternative sequencei101 – 1033LLT → QTF in isoform 3. 1 PublicationVSP_015303
    Alternative sequencei104 – 757654Missing in isoform 3. 1 PublicationVSP_015304Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF330046 mRNA. Translation: AAL37481.1.
    AY375528 mRNA. Translation: AAQ67659.1.
    AY370776 mRNA. Translation: AAQ73282.1.
    Y09631 Genomic DNA. Translation: CAA70844.1.
    AL354720, AL391384 Genomic DNA. Translation: CAI14869.1.
    AL391384, AL354720 Genomic DNA. Translation: CAI15673.1.
    BC051911 mRNA. Translation: AAH51911.1.
    CCDSiCCDS31991.1. [Q8WXW3-1]
    RefSeqiNP_006337.2. NM_006346.2. [Q8WXW3-1]
    UniGeneiHs.441926.

    Genome annotation databases

    EnsembliENST00000326291; ENSP00000317144; ENSG00000083535. [Q8WXW3-1]
    GeneIDi10464.
    KEGGihsa:10464.
    UCSCiuc001vjb.3. human. [Q8WXW3-1]
    uc010aep.3. human. [Q8WXW3-2]

    Polymorphism databases

    DMDMi73920251.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF330046 mRNA. Translation: AAL37481.1 .
    AY375528 mRNA. Translation: AAQ67659.1 .
    AY370776 mRNA. Translation: AAQ73282.1 .
    Y09631 Genomic DNA. Translation: CAA70844.1 .
    AL354720 , AL391384 Genomic DNA. Translation: CAI14869.1 .
    AL391384 , AL354720 Genomic DNA. Translation: CAI15673.1 .
    BC051911 mRNA. Translation: AAH51911.1 .
    CCDSi CCDS31991.1. [Q8WXW3-1 ]
    RefSeqi NP_006337.2. NM_006346.2. [Q8WXW3-1 ]
    UniGenei Hs.441926.

    3D structure databases

    ProteinModelPortali Q8WXW3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115727. 5 interactions.
    IntActi Q8WXW3. 7 interactions.
    STRINGi 9606.ENSP00000317144.

    PTM databases

    PhosphoSitei Q8WXW3.

    Polymorphism databases

    DMDMi 73920251.

    Proteomic databases

    MaxQBi Q8WXW3.
    PaxDbi Q8WXW3.
    PRIDEi Q8WXW3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326291 ; ENSP00000317144 ; ENSG00000083535 . [Q8WXW3-1 ]
    GeneIDi 10464.
    KEGGi hsa:10464.
    UCSCi uc001vjb.3. human. [Q8WXW3-1 ]
    uc010aep.3. human. [Q8WXW3-2 ]

    Organism-specific databases

    CTDi 10464.
    GeneCardsi GC13P073356.
    HGNCi HGNC:23352. PIBF1.
    HPAi HPA052269.
    MIMi 607532. gene.
    neXtProti NX_Q8WXW3.
    PharmGKBi PA162399421.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG116399.
    HOGENOMi HOG000006812.
    HOVERGENi HBG053599.
    InParanoidi Q8WXW3.
    KOi K16538.
    OMAi EYENKLH.
    OrthoDBi EOG7B8S3C.
    PhylomeDBi Q8WXW3.
    TreeFami TF329068.

    Miscellaneous databases

    GeneWikii C13orf24.
    GenomeRNAii 10464.
    NextBioi 39681.
    PROi Q8WXW3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WXW3.
    CleanExi HS_PIBF1.
    Genevestigatori Q8WXW3.

    Family and domain databases

    InterProi IPR026205. PIBF1.
    [Graphical view ]
    PANTHERi PTHR18950. PTHR18950. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Uterus.
    2. "PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome."
      Lachmann M., Gelbmann D., Kalman E., Polgar B., Buschle M., Von Gabain A., Szekeres-Bartho J., Nagy E.
      Int. J. Cancer 112:51-60(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
    3. Szekeres-Bartho J.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    6. Cited for: REVIEW.

    Entry informationi

    Entry nameiPIBF1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXW3
    Secondary accession number(s): O95664
    , Q6U9V2, Q6UG50, Q86V07, Q96SF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2003
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3