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Q8WXW3 (PIBF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Progesterone-induced-blocking factor 1
Gene names
Name:PIBF1
Synonyms:C13orf24, PIBF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length757 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.

Tissue specificity

Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon. Ref.1

Induction

By progesterone.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcentrosome

Inferred from direct assay PubMed 21399614. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 17500595. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HTTP428583EBI-2558770,EBI-466029

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WXW3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WXW3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-541: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8WXW3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     101-103: LLT → QTF
     104-757: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 757757Progesterone-induced-blocking factor 1
PRO_0000058426

Natural variations

Alternative sequence1 – 541541Missing in isoform 2.
VSP_015302
Alternative sequence101 – 1033LLT → QTF in isoform 3.
VSP_015303
Alternative sequence104 – 757654Missing in isoform 3.
VSP_015304
Natural variant1671I → V.
Corresponds to variant rs1372000 [ dbSNP | Ensembl ].
VAR_051279
Natural variant4051R → Q.
Corresponds to variant rs17089782 [ dbSNP | Ensembl ].
VAR_051280
Natural variant6301I → V.
Corresponds to variant rs11544631 [ dbSNP | Ensembl ].
VAR_051281

Experimental info

Sequence conflict1551N → S in CAA70844. Ref.3
Sequence conflict3331R → C in CAA70844. Ref.3
Sequence conflict597 – 61418DLEHR…QELDR → RSGTSKGPSNTAFTRSLTE in AAQ67659. Ref.3
Sequence conflict6101Q → P in AAL37481. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: B469FB3BCC7E80FD

FASTA75789,805
        10         20         30         40         50         60 
MSRKISKESK KVNISSSLES EDISLETTVP TDDISSSEER EGKVRITRQL IERKELLHNI 

        70         80         90        100        110        120 
QLLKIELSQK TMMIDNLKVD YLTKIEELEE KLNDALHQKQ LLTLRLDNQL AFQQKDASKY 

       130        140        150        160        170        180 
QELMKQEMET ILLRQKQLEE TNLQLREKAG DVRRNLRDFE LTEEQYIKLK AFPEDQLSIP 

       190        200        210        220        230        240 
EYVSVRFYEL VNPLRKEICE LQVKKNILAE ELSTNKNQLK QLTETYEEDR KNYSEVQIRC 

       250        260        270        280        290        300 
QRLALELADT KQLIQQGDYR QENYDKVKSE RDALEQEVIE LRRKHEILEA SHMIQTKERS 

       310        320        330        340        350        360 
ELSKEVVTLE QTVTLLQKDK EYLNRQNMEL SVRCAHEEDR LERLQAQLEE SKKAREEMYE 

       370        380        390        400        410        420 
KYVASRDHYK TEYENKLHDE LEQIRLKTNQ EIDQLRNASR EMYERENRNL REARDNAVAE 

       430        440        450        460        470        480 
KERAVMAEKD ALEKHDQLLD RYRELQLSTE SKVTEFLHQS KLKSFESERV QLLQEETARN 

       490        500        510        520        530        540 
LTQCQLECEK YQKKLEVLTK EFYSLQASSE KRITELQAQN SEHQARLDIY EKLEKELDEI 

       550        560        570        580        590        600 
IMQTAEIENE DEAERVLFSY GYGANVPTTA KRRLKQSVHL ARRVLQLEKQ NSLILKDLEH 

       610        620        630        640        650        660 
RKDQVTQLSQ ELDRANSLLN QTQQPYRYLI ESVRQRDSKI DSLTESIAQL EKDVSNLNKE 

       670        680        690        700        710        720 
KSALLQTKNQ MALDLEQLLN HREELAAMKQ ILVKMHSKHS ENSLLLTKTE PKHVTENQKS 

       730        740        750 
KTLNVPKEHE DNIFTPKPTL FTKKEAPEWS KKQKMKT 

« Hide

Isoform 2 [UniParc].

Checksum: 83A174B20DF2240F
Show »

FASTA21625,125
Isoform 3 [UniParc].

Checksum: DBD92AF3CD8037CB
Show »

FASTA10312,016

References

« Hide 'large scale' references
[1]"A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes."
Rozenblum E., Vahteristo P., Sandberg T., Bergthorsson J.T., Syrjakoski K., Weaver D., Haraldsson K., Johannsdottir H.K., Vehmanen P., Nigam S., Golberger N., Robbins C., Pak E., Dutra A., Gillander E., Stephan D.A., Bailey-Wilson J., Juo S.-H.H. expand/collapse author list , Kainu T., Arason A., Barkardottir R.B., Nevanlinna H., Borg A., Kallioniemi O.-P.
Hum. Genet. 110:111-121(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Uterus.
[2]"PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome."
Lachmann M., Gelbmann D., Kalman E., Polgar B., Buschle M., Von Gabain A., Szekeres-Bartho J., Nagy E.
Int. J. Cancer 112:51-60(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
[3]Szekeres-Bartho J.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[4]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[6]"Progesterone as an immunomodulatory molecule."
Szekeres-Bartho J., Barakonyi A., Par G., Polgar B., Palkovics T., Szereday L.
Int. Immunopharmacol. 1:1037-1048(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF330046 mRNA. Translation: AAL37481.1.
AY375528 mRNA. Translation: AAQ67659.1.
AY370776 mRNA. Translation: AAQ73282.1.
Y09631 Genomic DNA. Translation: CAA70844.1.
AL354720, AL391384 Genomic DNA. Translation: CAI14869.1.
AL391384, AL354720 Genomic DNA. Translation: CAI15673.1.
BC051911 mRNA. Translation: AAH51911.1.
CCDSCCDS31991.1. [Q8WXW3-1]
RefSeqNP_006337.2. NM_006346.2. [Q8WXW3-1]
UniGeneHs.441926.

3D structure databases

ProteinModelPortalQ8WXW3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115727. 5 interactions.
IntActQ8WXW3. 7 interactions.
STRING9606.ENSP00000317144.

PTM databases

PhosphoSiteQ8WXW3.

Polymorphism databases

DMDM73920251.

Proteomic databases

MaxQBQ8WXW3.
PaxDbQ8WXW3.
PRIDEQ8WXW3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326291; ENSP00000317144; ENSG00000083535. [Q8WXW3-1]
GeneID10464.
KEGGhsa:10464.
UCSCuc001vjb.3. human. [Q8WXW3-1]
uc010aep.3. human. [Q8WXW3-2]

Organism-specific databases

CTD10464.
GeneCardsGC13P073356.
HGNCHGNC:23352. PIBF1.
HPAHPA052269.
MIM607532. gene.
neXtProtNX_Q8WXW3.
PharmGKBPA162399421.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG116399.
HOGENOMHOG000006812.
HOVERGENHBG053599.
InParanoidQ8WXW3.
KOK16538.
OMAEYENKLH.
OrthoDBEOG7B8S3C.
PhylomeDBQ8WXW3.
TreeFamTF329068.

Gene expression databases

BgeeQ8WXW3.
CleanExHS_PIBF1.
GenevestigatorQ8WXW3.

Family and domain databases

InterProIPR026205. PIBF1.
[Graphical view]
PANTHERPTHR18950. PTHR18950. 1 hit.
ProtoNetSearch...

Other

GeneWikiC13orf24.
GenomeRNAi10464.
NextBio39681.
PROQ8WXW3.
SOURCESearch...

Entry information

Entry namePIBF1_HUMAN
AccessionPrimary (citable) accession number: Q8WXW3
Secondary accession number(s): O95664 expand/collapse secondary AC list , Q6U9V2, Q6UG50, Q86V07, Q96SF4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: August 30, 2005
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM