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Protein

Progesterone-induced-blocking factor 1

Gene

PIBF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.

Names & Taxonomyi

Protein namesi
Recommended name:
Progesterone-induced-blocking factor 1
Gene namesi
Name:PIBF1
Synonyms:C13orf24, PIBF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:23352. PIBF1.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Progesterone-induced-blocking factor 1PRO_0000058426Add
BLAST

Proteomic databases

MaxQBiQ8WXW3.
PaxDbiQ8WXW3.
PRIDEiQ8WXW3.

PTM databases

PhosphoSiteiQ8WXW3.

Expressioni

Tissue specificityi

Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon.1 Publication

Inductioni

By progesterone.

Gene expression databases

BgeeiQ8WXW3.
CleanExiHS_PIBF1.
GenevestigatoriQ8WXW3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-2558770,EBI-466029

Protein-protein interaction databases

BioGridi115727. 10 interactions.
IntActiQ8WXW3. 7 interactions.
STRINGi9606.ENSP00000317144.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG116399.
GeneTreeiENSGT00390000015293.
HOGENOMiHOG000006812.
HOVERGENiHBG053599.
InParanoidiQ8WXW3.
KOiK16538.
OMAiEYENKLH.
OrthoDBiEOG7B8S3C.
PhylomeDBiQ8WXW3.
TreeFamiTF329068.

Family and domain databases

InterProiIPR026205. PIBF1.
[Graphical view]
PANTHERiPTHR18950. PTHR18950. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRKISKESK KVNISSSLES EDISLETTVP TDDISSSEER EGKVRITRQL
60 70 80 90 100
IERKELLHNI QLLKIELSQK TMMIDNLKVD YLTKIEELEE KLNDALHQKQ
110 120 130 140 150
LLTLRLDNQL AFQQKDASKY QELMKQEMET ILLRQKQLEE TNLQLREKAG
160 170 180 190 200
DVRRNLRDFE LTEEQYIKLK AFPEDQLSIP EYVSVRFYEL VNPLRKEICE
210 220 230 240 250
LQVKKNILAE ELSTNKNQLK QLTETYEEDR KNYSEVQIRC QRLALELADT
260 270 280 290 300
KQLIQQGDYR QENYDKVKSE RDALEQEVIE LRRKHEILEA SHMIQTKERS
310 320 330 340 350
ELSKEVVTLE QTVTLLQKDK EYLNRQNMEL SVRCAHEEDR LERLQAQLEE
360 370 380 390 400
SKKAREEMYE KYVASRDHYK TEYENKLHDE LEQIRLKTNQ EIDQLRNASR
410 420 430 440 450
EMYERENRNL REARDNAVAE KERAVMAEKD ALEKHDQLLD RYRELQLSTE
460 470 480 490 500
SKVTEFLHQS KLKSFESERV QLLQEETARN LTQCQLECEK YQKKLEVLTK
510 520 530 540 550
EFYSLQASSE KRITELQAQN SEHQARLDIY EKLEKELDEI IMQTAEIENE
560 570 580 590 600
DEAERVLFSY GYGANVPTTA KRRLKQSVHL ARRVLQLEKQ NSLILKDLEH
610 620 630 640 650
RKDQVTQLSQ ELDRANSLLN QTQQPYRYLI ESVRQRDSKI DSLTESIAQL
660 670 680 690 700
EKDVSNLNKE KSALLQTKNQ MALDLEQLLN HREELAAMKQ ILVKMHSKHS
710 720 730 740 750
ENSLLLTKTE PKHVTENQKS KTLNVPKEHE DNIFTPKPTL FTKKEAPEWS

KKQKMKT
Length:757
Mass (Da):89,805
Last modified:August 30, 2005 - v2
Checksum:iB469FB3BCC7E80FD
GO
Isoform 2 (identifier: Q8WXW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-541: Missing.

Note: No experimental confirmation available.

Show »
Length:216
Mass (Da):25,125
Checksum:i83A174B20DF2240F
GO
Isoform 3 (identifier: Q8WXW3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-103: LLT → QTF
     104-757: Missing.

Note: No experimental confirmation available.

Show »
Length:103
Mass (Da):12,016
Checksum:iDBD92AF3CD8037CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 1551N → S in CAA70844 (Ref. 3) Curated
Sequence conflicti333 – 3331R → C in CAA70844 (Ref. 3) Curated
Sequence conflicti597 – 61418DLEHR…QELDR → RSGTSKGPSNTAFTRSLTE in AAQ67659 (Ref. 3) CuratedAdd
BLAST
Sequence conflicti610 – 6101Q → P in AAL37481 (PubMed:11935316).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671I → V.
Corresponds to variant rs1372000 [ dbSNP | Ensembl ].
VAR_051279
Natural varianti405 – 4051R → Q.
Corresponds to variant rs17089782 [ dbSNP | Ensembl ].
VAR_051280
Natural varianti630 – 6301I → V.
Corresponds to variant rs11544631 [ dbSNP | Ensembl ].
VAR_051281

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 541541Missing in isoform 2. 1 PublicationVSP_015302Add
BLAST
Alternative sequencei101 – 1033LLT → QTF in isoform 3. 1 PublicationVSP_015303
Alternative sequencei104 – 757654Missing in isoform 3. 1 PublicationVSP_015304Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330046 mRNA. Translation: AAL37481.1.
AY375528 mRNA. Translation: AAQ67659.1.
AY370776 mRNA. Translation: AAQ73282.1.
Y09631 Genomic DNA. Translation: CAA70844.1.
AL354720, AL391384 Genomic DNA. Translation: CAI14869.1.
AL391384, AL354720 Genomic DNA. Translation: CAI15673.1.
BC051911 mRNA. Translation: AAH51911.1.
CCDSiCCDS31991.1. [Q8WXW3-1]
RefSeqiNP_006337.2. NM_006346.2. [Q8WXW3-1]
UniGeneiHs.441926.

Genome annotation databases

EnsembliENST00000326291; ENSP00000317144; ENSG00000083535. [Q8WXW3-1]
ENST00000615625; ENSP00000483286; ENSG00000083535. [Q8WXW3-2]
GeneIDi10464.
KEGGihsa:10464.
UCSCiuc001vjb.3. human. [Q8WXW3-1]
uc010aep.3. human. [Q8WXW3-2]

Polymorphism databases

DMDMi73920251.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330046 mRNA. Translation: AAL37481.1.
AY375528 mRNA. Translation: AAQ67659.1.
AY370776 mRNA. Translation: AAQ73282.1.
Y09631 Genomic DNA. Translation: CAA70844.1.
AL354720, AL391384 Genomic DNA. Translation: CAI14869.1.
AL391384, AL354720 Genomic DNA. Translation: CAI15673.1.
BC051911 mRNA. Translation: AAH51911.1.
CCDSiCCDS31991.1. [Q8WXW3-1]
RefSeqiNP_006337.2. NM_006346.2. [Q8WXW3-1]
UniGeneiHs.441926.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115727. 10 interactions.
IntActiQ8WXW3. 7 interactions.
STRINGi9606.ENSP00000317144.

PTM databases

PhosphoSiteiQ8WXW3.

Polymorphism databases

DMDMi73920251.

Proteomic databases

MaxQBiQ8WXW3.
PaxDbiQ8WXW3.
PRIDEiQ8WXW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326291; ENSP00000317144; ENSG00000083535. [Q8WXW3-1]
ENST00000615625; ENSP00000483286; ENSG00000083535. [Q8WXW3-2]
GeneIDi10464.
KEGGihsa:10464.
UCSCiuc001vjb.3. human. [Q8WXW3-1]
uc010aep.3. human. [Q8WXW3-2]

Organism-specific databases

CTDi10464.
GeneCardsiGC13P073356.
HGNCiHGNC:23352. PIBF1.
MIMi607532. gene.
neXtProtiNX_Q8WXW3.
PharmGKBiPA162399421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG116399.
GeneTreeiENSGT00390000015293.
HOGENOMiHOG000006812.
HOVERGENiHBG053599.
InParanoidiQ8WXW3.
KOiK16538.
OMAiEYENKLH.
OrthoDBiEOG7B8S3C.
PhylomeDBiQ8WXW3.
TreeFamiTF329068.

Miscellaneous databases

ChiTaRSiPIBF1. human.
GeneWikiiC13orf24.
GenomeRNAii10464.
NextBioi39681.
PROiQ8WXW3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WXW3.
CleanExiHS_PIBF1.
GenevestigatoriQ8WXW3.

Family and domain databases

InterProiIPR026205. PIBF1.
[Graphical view]
PANTHERiPTHR18950. PTHR18950. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Uterus.
  2. "PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome."
    Lachmann M., Gelbmann D., Kalman E., Polgar B., Buschle M., Von Gabain A., Szekeres-Bartho J., Nagy E.
    Int. J. Cancer 112:51-60(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
  3. Szekeres-Bartho J.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  6. Cited for: REVIEW.

Entry informationi

Entry nameiPIBF1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXW3
Secondary accession number(s): O95664
, Q6U9V2, Q6UG50, Q86V07, Q96SF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: August 30, 2005
Last modified: April 1, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.