Q8WXW3 (PIBF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Progesterone-induced-blocking factor 1

Gene names

Name:	PIBF1
Synonyms:	C13orf24, PIBF

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	757 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.
Tissue specificity	Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon. Ref.1
Induction	By progesterone.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	centrosome Inferred from direct assay PubMed 21399614. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WXW3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WXW3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-541: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8WXW3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     101-103: LLT → QTF
     104-757: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 757	757	Progesterone-induced-blocking factor 1		PRO_0000058426
Natural variations
	Alternative sequence	1 – 541	541	Missing in isoform 2.		VSP_015302
	Alternative sequence	101 – 103	3	LLT → QTF in isoform 3.		VSP_015303
	Alternative sequence	104 – 757	654	Missing in isoform 3.		VSP_015304
	Natural variant	167	1	I → V. Corresponds to variant rs1372000 [ dbSNP | Ensembl ].		VAR_051279
	Natural variant	405	1	R → Q. Corresponds to variant rs17089782 [ dbSNP | Ensembl ].		VAR_051280
	Natural variant	630	1	I → V. Corresponds to variant rs11544631 [ dbSNP | Ensembl ].		VAR_051281
Experimental info
	Sequence conflict	155	1	N → S in CAA70844. Ref.3
	Sequence conflict	333	1	R → C in CAA70844. Ref.3
	Sequence conflict	597 – 614	18	DLEHR…QELDR → RSGTSKGPSNTAFTRSLTE in AAQ67659. Ref.3
	Sequence conflict	610	1	Q → P in AAL37481. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: B469FB3BCC7E80FD	FASTA	757	89,805
	10 20 30 40 50 60 MSRKISKESK KVNISSSLES EDISLETTVP TDDISSSEER EGKVRITRQL IERKELLHNI 70 80 90 100 110 120 QLLKIELSQK TMMIDNLKVD YLTKIEELEE KLNDALHQKQ LLTLRLDNQL AFQQKDASKY 130 140 150 160 170 180 QELMKQEMET ILLRQKQLEE TNLQLREKAG DVRRNLRDFE LTEEQYIKLK AFPEDQLSIP 190 200 210 220 230 240 EYVSVRFYEL VNPLRKEICE LQVKKNILAE ELSTNKNQLK QLTETYEEDR KNYSEVQIRC 250 260 270 280 290 300 QRLALELADT KQLIQQGDYR QENYDKVKSE RDALEQEVIE LRRKHEILEA SHMIQTKERS 310 320 330 340 350 360 ELSKEVVTLE QTVTLLQKDK EYLNRQNMEL SVRCAHEEDR LERLQAQLEE SKKAREEMYE 370 380 390 400 410 420 KYVASRDHYK TEYENKLHDE LEQIRLKTNQ EIDQLRNASR EMYERENRNL REARDNAVAE 430 440 450 460 470 480 KERAVMAEKD ALEKHDQLLD RYRELQLSTE SKVTEFLHQS KLKSFESERV QLLQEETARN 490 500 510 520 530 540 LTQCQLECEK YQKKLEVLTK EFYSLQASSE KRITELQAQN SEHQARLDIY EKLEKELDEI 550 560 570 580 590 600 IMQTAEIENE DEAERVLFSY GYGANVPTTA KRRLKQSVHL ARRVLQLEKQ NSLILKDLEH 610 620 630 640 650 660 RKDQVTQLSQ ELDRANSLLN QTQQPYRYLI ESVRQRDSKI DSLTESIAQL EKDVSNLNKE 670 680 690 700 710 720 KSALLQTKNQ MALDLEQLLN HREELAAMKQ ILVKMHSKHS ENSLLLTKTE PKHVTENQKS 730 740 750 KTLNVPKEHE DNIFTPKPTL FTKKEAPEWS KKQKMKT
	Isoform 2 [UniParc]. Checksum: 83A174B20DF2240F	FASTA	216	25,125
	10 20 30 40 50 60 MQTAEIENED EAERVLFSYG YGANVPTTAK RRLKQSVHLA RRVLQLEKQN SLILKDLEHR 70 80 90 100 110 120 KDQVTQLSQE LDRANSLLNQ TQQPYRYLIE SVRQRDSKID SLTESIAQLE KDVSNLNKEK 130 140 150 160 170 180 SALLQTKNQM ALDLEQLLNH REELAAMKQI LVKMHSKHSE NSLLLTKTEP KHVTENQKSK 190 200 210 TLNVPKEHED NIFTPKPTLF TKKEAPEWSK KQKMKT
	Isoform 3 [UniParc]. Checksum: DBD92AF3CD8037CB	FASTA	103	12,016
	10 20 30 40 50 60 MSRKISKESK KVNISSSLES EDISLETTVP TDDISSSEER EGKVRITRQL IERKELLHNI 70 80 90 100 QLLKIELSQK TMMIDNLKVD YLTKIEELEE KLNDALHQKQ QTF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes." Rozenblum E., Vahteristo P., Sandberg T., Bergthorsson J.T., Syrjakoski K., Weaver D., Haraldsson K., Johannsdottir H.K., Vehmanen P., Nigam S., Golberger N., Robbins C., Pak E., Dutra A., Gillander E., Stephan D.A., Bailey-Wilson J., Juo S.-H.H. , Kainu T., Arason A., Barkardottir R.B., Nevanlinna H., Borg A., Kallioniemi O.-P. Hum. Genet. 110:111-121(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Uterus.
[2]	"PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome." Lachmann M., Gelbmann D., Kalman E., Polgar B., Buschle M., Von Gabain A., Szekeres-Bartho J., Nagy E. Int. J. Cancer 112:51-60(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
[3]	Szekeres-Bartho J. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye.
[6]	"Progesterone as an immunomodulatory molecule." Szekeres-Bartho J., Barakonyi A., Par G., Polgar B., Palkovics T., Szereday L. Int. Immunopharmacol. 1:1037-1048(2001) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF330046 mRNA. Translation: AAL37481.1. AY375528 mRNA. Translation: AAQ67659.1. AY370776 mRNA. Translation: AAQ73282.1. Y09631 Genomic DNA. Translation: CAA70844.1. AL354720, AL391384 Genomic DNA. Translation: CAI14869.1. AL391384, AL354720 Genomic DNA. Translation: CAI15673.1. BC051911 mRNA. Translation: AAH51911.1.
IPI	IPI00328765. IPI00643109. IPI00643693.
RefSeq	NP_006337.2. NM_006346.2.
UniGene	Hs.441926.
3D structure databases
ProteinModelPortal	Q8WXW3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WXW3. 5 interactions.
STRING	9606.ENSP00000317144.
PTM databases
PhosphoSite	Q8WXW3.
Polymorphism databases
DMDM	73920251.
Proteomic databases
PaxDb	Q8WXW3.
PRIDE	Q8WXW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326291; ENSP00000317144; ENSG00000083535.
GeneID	10464.
KEGG	hsa:10464.
UCSC	uc001vjb.3. human. uc010aep.3. human.
Organism-specific databases
CTD	10464.
GeneCards	GC13P073356.
HGNC	HGNC:23352. PIBF1.
MIM	607532. gene.
neXtProt	NX_Q8WXW3.
PharmGKB	PA162399421.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG116399.
HOGENOM	HOG000006812.
HOVERGEN	HBG053599.
InParanoid	Q8WXW3.
KO	K16538.
OMA	EYENKLH.
OrthoDB	EOG4320XJ.
Gene expression databases
Bgee	Q8WXW3.
CleanEx	HS_PIBF1.
Genevestigator	Q8WXW3.
Family and domain databases
InterPro	IPR026205. PIBF1. [Graphical view]
PANTHER	PTHR18950. PTHR18950. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	10464.
NextBio	39681.
SOURCE	Search...

Entry information

Entry name

PIBF1_HUMAN

Accession

Primary (citable) accession number: Q8WXW3
Secondary accession number(s): O95664 , Q6U9V2, Q6UG50, Q86V07, Q96SF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 22, 2003
Last sequence update:	August 30, 2005
Last modified:	April 3, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.