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Q8WXU1

- Q8WXU1_HUMAN

UniProt

Q8WXU1 - Q8WXU1_HUMAN

Protein
Submitted name:

BCL2-associated X protein

Gene

BAX

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Ensembl
    2. activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
    3. apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
    4. apoptotic process involved in patterning of blood vessels Source: Ensembl
    5. B cell apoptotic process Source: Ensembl
    6. B cell homeostasis Source: Ensembl
    7. B cell homeostatic proliferation Source: Ensembl
    8. B cell negative selection Source: Ensembl
    9. blood vessel remodeling Source: Ensembl
    10. cellular response to organic substance Source: Ensembl
    11. cellular response to UV Source: Ensembl
    12. cerebral cortex development Source: Ensembl
    13. development of secondary sexual characteristics Source: Ensembl
    14. ectopic germ cell programmed cell death Source: Ensembl
    15. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    16. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    17. fertilization Source: Ensembl
    18. germ cell development Source: Ensembl
    19. glycosphingolipid metabolic process Source: Ensembl
    20. homeostasis of number of cells within a tissue Source: Ensembl
    21. hypothalamus development Source: Ensembl
    22. intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
    23. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    24. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
    25. kidney development Source: Ensembl
    26. myeloid cell homeostasis Source: Ensembl
    27. negative regulation of apoptotic signaling pathway Source: Ensembl
    28. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
    29. negative regulation of fibroblast proliferation Source: Ensembl
    30. negative regulation of neuron apoptotic process Source: Ensembl
    31. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
    32. neuron apoptotic process Source: Ensembl
    33. neuron migration Source: Ensembl
    34. nuclear fragmentation involved in apoptotic nuclear change Source: Ensembl
    35. odontogenesis of dentin-containing tooth Source: Ensembl
    36. ovarian follicle development Source: Ensembl
    37. positive regulation of apoptotic process involved in mammary gland involution Source: Ensembl
    38. positive regulation of B cell apoptotic process Source: Ensembl
    39. positive regulation of developmental pigmentation Source: Ensembl
    40. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    41. positive regulation of neuron apoptotic process Source: Ensembl
    42. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    43. post-embryonic camera-type eye morphogenesis Source: Ensembl
    44. protein homooligomerization Source: Ensembl
    45. protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Ensembl
    46. regulation of cell cycle Source: Ensembl
    47. regulation of mammary gland epithelial cell proliferation Source: Ensembl
    48. regulation of nitrogen utilization Source: Ensembl
    49. release of cytochrome c from mitochondria Source: Ensembl
    50. response to acid chemical Source: Ensembl
    51. response to axon injury Source: Ensembl
    52. response to gamma radiation Source: Ensembl
    53. response to salt stress Source: Ensembl
    54. response to toxic substance Source: Ensembl
    55. retina development in camera-type eye Source: Ensembl
    56. retinal cell programmed cell death Source: Ensembl
    57. Sertoli cell proliferation Source: Ensembl
    58. spermatid differentiation Source: Ensembl
    59. T cell homeostatic proliferation Source: Ensembl
    60. thymocyte apoptotic process Source: Ensembl
    61. vagina development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    BCL2-associated X proteinImported
    Gene namesi
    Name:BAXImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. endoplasmic reticulum Source: Ensembl
    3. mitochondrial outer membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8WXU1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WXU1.
    BgeeiQ8WXU1.

    Sequencei

    Sequence statusi: Fragment.

    Q8WXU1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGSGEQPRG GGPTSSEQIM KTGA                               24
    Length:24
    Mass (Da):2,379
    Last modified:March 1, 2002 - v1
    Checksum:i8C3D3E8B7479B798
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei24 – 241Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF339054 Genomic DNA. Translation: AAL73333.1.
    UniGeneiHs.624291.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF339054 Genomic DNA. Translation: AAL73333.1 .
    UniGenei Hs.624291.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8WXU1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    ChiTaRSi BAX. human.

    Gene expression databases

    ArrayExpressi Q8WXU1.
    Bgeei Q8WXU1.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes."
      Thornborrow E.C., Patel S., Mastropietro A.E., Schwartzfarb E.M., Manfredi J.J.
      Oncogene 21:990-999(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ8WXU1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXU1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.