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Q8WXU1

- Q8WXU1_HUMAN

UniProt

Q8WXU1 - Q8WXU1_HUMAN

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Protein
Submitted name:

BCL2-associated X protein

Gene

BAX

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Ensembl
  2. activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
  3. apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
  4. apoptotic process involved in patterning of blood vessels Source: Ensembl
  5. B cell apoptotic process Source: Ensembl
  6. B cell homeostasis Source: Ensembl
  7. B cell homeostatic proliferation Source: Ensembl
  8. B cell negative selection Source: Ensembl
  9. blood vessel remodeling Source: Ensembl
  10. cellular response to organic substance Source: Ensembl
  11. cellular response to UV Source: Ensembl
  12. cerebral cortex development Source: Ensembl
  13. development of secondary sexual characteristics Source: Ensembl
  14. ectopic germ cell programmed cell death Source: Ensembl
  15. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  16. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  17. fertilization Source: Ensembl
  18. germ cell development Source: Ensembl
  19. glycosphingolipid metabolic process Source: Ensembl
  20. homeostasis of number of cells within a tissue Source: Ensembl
  21. hypothalamus development Source: Ensembl
  22. intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
  23. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  24. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
  25. kidney development Source: Ensembl
  26. mitochondrion morphogenesis Source: Ensembl
  27. myeloid cell homeostasis Source: Ensembl
  28. negative regulation of apoptotic signaling pathway Source: Ensembl
  29. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
  30. negative regulation of fibroblast proliferation Source: Ensembl
  31. negative regulation of neuron apoptotic process Source: Ensembl
  32. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  33. neuron apoptotic process Source: Ensembl
  34. neuron migration Source: Ensembl
  35. odontogenesis of dentin-containing tooth Source: Ensembl
  36. ovarian follicle development Source: Ensembl
  37. positive regulation of apoptotic process involved in mammary gland involution Source: Ensembl
  38. positive regulation of B cell apoptotic process Source: Ensembl
  39. positive regulation of developmental pigmentation Source: Ensembl
  40. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  41. positive regulation of neuron apoptotic process Source: Ensembl
  42. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  43. post-embryonic camera-type eye morphogenesis Source: Ensembl
  44. protein homooligomerization Source: Ensembl
  45. protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Ensembl
  46. regulation of cell cycle Source: Ensembl
  47. regulation of mammary gland epithelial cell proliferation Source: Ensembl
  48. regulation of mitochondrial membrane permeability involved in programmed necrotic cell death Source: Ensembl
  49. regulation of nitrogen utilization Source: Ensembl
  50. release of cytochrome c from mitochondria Source: Ensembl
  51. response to axon injury Source: Ensembl
  52. response to gamma radiation Source: Ensembl
  53. response to salt stress Source: Ensembl
  54. response to toxic substance Source: Ensembl
  55. retina development in camera-type eye Source: Ensembl
  56. retinal cell programmed cell death Source: Ensembl
  57. Sertoli cell proliferation Source: Ensembl
  58. spermatid differentiation Source: Ensembl
  59. T cell homeostatic proliferation Source: Ensembl
  60. thymocyte apoptotic process Source: Ensembl
  61. vagina development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
BCL2-associated X proteinImported
Gene namesi
Name:BAXImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endoplasmic reticulum Source: Ensembl
  3. mitochondrial outer membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8WXU1.

Expressioni

Gene expression databases

BgeeiQ8WXU1.
ExpressionAtlasiQ8WXU1. baseline and differential.

Sequencei

Sequence statusi: Fragment.

Q8WXU1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20
MDGSGEQPRG GGPTSSEQIM KTGA
Length:24
Mass (Da):2,379
Last modified:March 1, 2002 - v1
Checksum:i8C3D3E8B7479B798
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei24 – 241Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF339054 Genomic DNA. Translation: AAL73333.1.
UniGeneiHs.624291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF339054 Genomic DNA. Translation: AAL73333.1 .
UniGenei Hs.624291.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8WXU1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

ChiTaRSi BAX. human.

Gene expression databases

Bgeei Q8WXU1.
ExpressionAtlasi Q8WXU1. baseline and differential.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes."
    Thornborrow E.C., Patel S., Mastropietro A.E., Schwartzfarb E.M., Manfredi J.J.
    Oncogene 21:990-999(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8WXU1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXU1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.