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Q8WXT5

- FX4L4_HUMAN

UniProt

Q8WXT5 - FX4L4_HUMAN

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Protein

Forkhead box protein D4-like 4

Gene

FOXD4L4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi108 – 20295Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 4
Short name:
FOXD4-like 4
Alternative name(s):
Forkhead box protein D4B
Myeloid factor-gamma
Gene namesi
Name:FOXD4L4
Synonyms:FOXD4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23762. FOXD4L4.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671752.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Forkhead box protein D4-like 4PRO_0000091825Add
BLAST

Proteomic databases

PaxDbiQ8WXT5.
PRIDEiQ8WXT5.

PTM databases

PhosphoSiteiQ8WXT5.

Expressioni

Gene expression databases

BgeeiQ8WXT5.
CleanExiHS_FOXD4L4.
GenevestigatoriQ8WXT5.

Organism-specific databases

HPAiHPA012836.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366630.

Structurei

3D structure databases

ProteinModelPortaliQ8WXT5.
SMRiQ8WXT5. Positions 108-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 26757Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ8WXT5.
KOiK09397.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ8WXT5.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS
110 120 130 140 150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP
160 170 180 190 200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR
210 220 230 240 250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY
260 270 280 290 300
PNTAPGRRPY ALLHPHPLRY LLLSARVYAG APKKAEGADL ATPAPFPCCS
310 320 330 340 350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG
360 370 380 390 400
ATATCSSDHQ ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP
410
PRARCWAGTC RPRRRC
Length:416
Mass (Da):45,892
Last modified:September 11, 2007 - v2
Checksum:iCA8FCD2D09B5CBC8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti280 – 2801G → A in AAL73342. (PubMed:12234674)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343005 Genomic DNA. Translation: AAL73342.1.
BX284632 Genomic DNA. Translation: CAI14283.1.
CCDSiCCDS75845.1.
RefSeqiNP_954714.2. NM_199244.3.
UniGeneiHs.712520.

Genome annotation databases

EnsembliENST00000377413; ENSP00000366630; ENSG00000184659.
GeneIDi349334.
KEGGihsa:349334.

Polymorphism databases

DMDMi158518651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343005 Genomic DNA. Translation: AAL73342.1 .
BX284632 Genomic DNA. Translation: CAI14283.1 .
CCDSi CCDS75845.1.
RefSeqi NP_954714.2. NM_199244.3.
UniGenei Hs.712520.

3D structure databases

ProteinModelPortali Q8WXT5.
SMRi Q8WXT5. Positions 108-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000366630.

PTM databases

PhosphoSitei Q8WXT5.

Polymorphism databases

DMDMi 158518651.

Proteomic databases

PaxDbi Q8WXT5.
PRIDEi Q8WXT5.

Protocols and materials databases

DNASUi 349334.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377413 ; ENSP00000366630 ; ENSG00000184659 .
GeneIDi 349334.
KEGGi hsa:349334.

Organism-specific databases

CTDi 349334.
GeneCardsi GC09M070427.
HGNCi HGNC:23762. FOXD4L4.
HPAi HPA012836.
neXtProti NX_Q8WXT5.
PharmGKBi PA142671752.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00760000118904.
HOGENOMi HOG000231285.
HOVERGENi HBG051641.
InParanoidi Q8WXT5.
KOi K09397.
OrthoDBi EOG7C8GHD.
PhylomeDBi Q8WXT5.
TreeFami TF316127.

Miscellaneous databases

NextBioi 136087.
PROi Q8WXT5.

Gene expression databases

Bgeei Q8WXT5.
CleanExi HS_FOXD4L4.
Genevestigatori Q8WXT5.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines."
    Freyaldenhoven B.S., Fried C., Wielckens K.
    Gene 294:131-140(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFX4L4_HUMAN
AccessioniPrimary (citable) accession number: Q8WXT5
Secondary accession number(s): Q5RIB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3