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Protein

Forkhead box protein D4-like 4

Gene

FOXD4L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi108 – 202Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 4Curated
Short name:
FOXD4-like 4Curated
Alternative name(s):
Forkhead box protein D4-like 2Imported
Forkhead box protein D4B1 Publication
Myeloid factor-gammaImported
Gene namesi
Name:FOXD4L4Imported
Synonyms:FOXD4B1 Publication, FOXD4L2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23762. FOXD4L4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184659.
PharmGKBiPA142671752.

Polymorphism and mutation databases

BioMutaiFOXD4L2.
DMDMi158518651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918251 – 416Forkhead box protein D4-like 4Add BLAST416

Proteomic databases

EPDiQ8WXT5.
PaxDbiQ8WXT5.
PeptideAtlasiQ8WXT5.

Expressioni

Gene expression databases

CleanExiHS_FOXD4L2.
HS_FOXD4L4.

Organism-specific databases

HPAiHPA012836.

Interactioni

Protein-protein interaction databases

IntActiQ8WXT5. 2 interactors.
STRINGi9606.ENSP00000366814.

Structurei

3D structure databases

ProteinModelPortaliQ8WXT5.
SMRiQ8WXT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 267Pro-richAdd BLAST57

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ8WXT5.
KOiK09397.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ8WXT5.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WXT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS
110 120 130 140 150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP
160 170 180 190 200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR
210 220 230 240 250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY
260 270 280 290 300
PNTAPGRRPY ALLHPHPLRY LLLSARVYAG APKKAEGADL ATPAPFPCCS
310 320 330 340 350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG
360 370 380 390 400
ATATCSSDHQ ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP
410
PRARCWAGTC RPRRRC
Length:416
Mass (Da):45,892
Last modified:September 11, 2007 - v2
Checksum:iCA8FCD2D09B5CBC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280G → A in AAL73342 (PubMed:12234674).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343005 Genomic DNA. Translation: AAL73342.1.
AY344641 mRNA. Translation: AAQ76879.1.
BX284632 Genomic DNA. Translation: CAI14283.1.
CCDSiCCDS75845.1.
RefSeqiNP_954714.2. NM_199244.3.
UniGeneiHs.449471.
Hs.712520.

Genome annotation databases

EnsembliENST00000377413; ENSP00000366630; ENSG00000184659.
GeneIDi349334.
KEGGihsa:349334.
UCSCiuc004afx.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343005 Genomic DNA. Translation: AAL73342.1.
AY344641 mRNA. Translation: AAQ76879.1.
BX284632 Genomic DNA. Translation: CAI14283.1.
CCDSiCCDS75845.1.
RefSeqiNP_954714.2. NM_199244.3.
UniGeneiHs.449471.
Hs.712520.

3D structure databases

ProteinModelPortaliQ8WXT5.
SMRiQ8WXT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8WXT5. 2 interactors.
STRINGi9606.ENSP00000366814.

Polymorphism and mutation databases

BioMutaiFOXD4L2.
DMDMi158518651.

Proteomic databases

EPDiQ8WXT5.
PaxDbiQ8WXT5.
PeptideAtlasiQ8WXT5.

Protocols and materials databases

DNASUi349334.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377413; ENSP00000366630; ENSG00000184659.
GeneIDi349334.
KEGGihsa:349334.
UCSCiuc004afx.2. human.

Organism-specific databases

CTDi349334.
GeneCardsiFOXD4L4.
HGNCiHGNC:23762. FOXD4L4.
HPAiHPA012836.
MIMi611085. gene.
neXtProtiNX_Q8WXT5.
OpenTargetsiENSG00000184659.
PharmGKBiPA142671752.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ8WXT5.
KOiK09397.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ8WXT5.
TreeFamiTF316127.

Miscellaneous databases

GenomeRNAii349334.
PROiQ8WXT5.
SOURCEiSearch...

Gene expression databases

CleanExiHS_FOXD4L2.
HS_FOXD4L4.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFX4L4_HUMAN
AccessioniPrimary (citable) accession number: Q8WXT5
Secondary accession number(s): Q5RIB4, Q6VB85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: September 11, 2007
Last modified: March 15, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.