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Q8WXT5 (FX4L4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein D4-like 4

Short name=FOXD4-like 4
Alternative name(s):
Forkhead box protein D4B
Myeloid factor-gamma
Gene names
Name:FOXD4L4
Synonyms:FOXD4B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Miscellaneous

5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Forkhead box protein D4-like 4
PRO_0000091825

Regions

DNA binding108 – 20295Fork-head
Compositional bias211 – 26757Pro-rich

Experimental info

Sequence conflict2801G → A in AAL73342. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8WXT5 [UniParc].

Last modified September 11, 2007. Version 2.
Checksum: CA8FCD2D09B5CBC8

FASTA41645,892
        10         20         30         40         50         60 
MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF LEQSLQPGLQ 

        70         80         90        100        110        120 
VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA 

       130        140        150        160        170        180 
ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN 

       190        200        210        220        230        240 
YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP 

       250        260        270        280        290        300 
APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSARVYAG APKKAEGADL ATPAPFPCCS 

       310        320        330        340        350        360 
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ 

       370        380        390        400        410 
ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP PRARCWAGTC RPRRRC 

« Hide

References

« Hide 'large scale' references
[1]"FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines."
Freyaldenhoven B.S., Fried C., Wielckens K.
Gene 294:131-140(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF343005 Genomic DNA. Translation: AAL73342.1.
BX284632 Genomic DNA. Translation: CAI14283.1.
CCDSCCDS6621.1.
RefSeqNP_954714.2. NM_199244.3.
UniGeneHs.712520.

3D structure databases

ProteinModelPortalQ8WXT5.
SMRQ8WXT5. Positions 108-203.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000366630.

PTM databases

PhosphoSiteQ8WXT5.

Polymorphism databases

DMDM158518651.

Proteomic databases

PaxDbQ8WXT5.
PRIDEQ8WXT5.

Protocols and materials databases

DNASU349334.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377413; ENSP00000366630; ENSG00000184659.
GeneID349334.
KEGGhsa:100036519.
hsa:349334.

Organism-specific databases

CTD349334.
GeneCardsGC09M070427.
HGNCHGNC:23762. FOXD4L4.
HPAHPA012836.
neXtProtNX_Q8WXT5.
PharmGKBPA142671752.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000231285.
HOVERGENHBG051641.
InParanoidQ8WXT5.
KOK09397.
OrthoDBEOG7C8GHD.
PhylomeDBQ8WXT5.
TreeFamTF316127.

Gene expression databases

BgeeQ8WXT5.
CleanExHS_FOXD4L4.
GenevestigatorQ8WXT5.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio136087.
PROQ8WXT5.

Entry information

Entry nameFX4L4_HUMAN
AccessionPrimary (citable) accession number: Q8WXT5
Secondary accession number(s): Q5RIB4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: September 11, 2007
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM