Q8WXT5 (FX4L4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein D4-like 4
Short name=FOXD4-like 4

Alternative name(s):
Forkhead box protein D4B
Myeloid factor-gamma

Gene names

Name:	FOXD4L4
Synonyms:	FOXD4B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Miscellaneous	5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon extension involved in axon guidance Inferred from Biological aspect of Ancestor. Source: RefGenome cartilage development Inferred from Biological aspect of Ancestor. Source: RefGenome dichotomous subdivision of terminal units involved in ureteric bud branching Inferred from Biological aspect of Ancestor. Source: RefGenome embryo development Inferred from Biological aspect of Ancestor. Source: RefGenome enteric nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome iridophore differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome lateral line nerve glial cell development Inferred from Biological aspect of Ancestor. Source: RefGenome melanocyte differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome neural crest cell migration Inferred from Biological aspect of Ancestor. Source: RefGenome pattern specification process Inferred from Biological aspect of Ancestor. Source: RefGenome peripheral nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of BMP signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of kidney development Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome sympathetic nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Forkhead box protein D4-like 4		PRO_0000091825
Regions
	DNA binding	108 – 202	95	Fork-head
	Compositional bias	211 – 267	57	Pro-rich
Experimental info
	Sequence conflict	280	1	G → A in AAL73342. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8WXT5 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: CA8FCD2D09B5CBC8	FASTA	416	45,892
	10 20 30 40 50 60 MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF LEQSLQPGLQ 70 80 90 100 110 120 VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA 130 140 150 160 170 180 ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN 190 200 210 220 230 240 YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP 250 260 270 280 290 300 APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSARVYAG APKKAEGADL ATPAPFPCCS 310 320 330 340 350 360 PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ 370 380 390 400 410 ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP PRARCWAGTC RPRRRC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines." Freyaldenhoven B.S., Fried C., Wielckens K. Gene 294:131-140(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF343005 Genomic DNA. Translation: AAL73342.1. BX284632 Genomic DNA. Translation: CAI14283.1.
IPI	IPI00847706.
RefSeq	NP_001092749.1. NM_001099279.1. NP_954714.2. NM_199244.2.
UniGene	Hs.534644. Hs.712520.
3D structure databases
ProteinModelPortal	Q8WXT5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000366630.
PTM databases
PhosphoSite	Q8WXT5.
Proteomic databases
PaxDb	Q8WXT5.
PRIDE	Q8WXT5.
Protocols and materials databases
DNASU	349334.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377413; ENSP00000366630; ENSG00000184659.
GeneID	100036519. 349334.
KEGG	hsa:100036519. hsa:349334.
Organism-specific databases
CTD	100036519. 349334.
GeneCards	GC09M070427.
HGNC	HGNC:23762. FOXD4L4.
HPA	HPA012836.
neXtProt	NX_Q8WXT5.
PharmGKB	PA142671752.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5025.
HOGENOM	HOG000231285.
HOVERGEN	HBG051641.
InParanoid	Q8WXT5.
KO	K09397.
OrthoDB	EOG4JM7Q5.
PhylomeDB	Q8WXT5.
Gene expression databases
ArrayExpress	Q8WXT5.
Bgee	Q8WXT5.
CleanEx	HS_FOXD4L4.
Genevestigator	Q8WXT5.
GermOnline	ENSG00000204828. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	136087.

Entry information

Entry name

FX4L4_HUMAN

Accession

Primary (citable) accession number: Q8WXT5
Secondary accession number(s): Q5RIB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.