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Protein

Forkhead box protein D4-like 4

Gene

FOXD4L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi108 – 20295Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 4
Short name:
FOXD4-like 4
Alternative name(s):
Forkhead box protein D4B
Myeloid factor-gamma
Gene namesi
Name:FOXD4L4
Synonyms:FOXD4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23762. FOXD4L4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671752.

Polymorphism and mutation databases

DMDMi158518651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Forkhead box protein D4-like 4PRO_0000091825Add
BLAST

Proteomic databases

PaxDbiQ8WXT5.
PRIDEiQ8WXT5.

PTM databases

PhosphoSiteiQ8WXT5.

Expressioni

Gene expression databases

BgeeiQ8WXT5.
CleanExiHS_FOXD4L4.
ExpressionAtlasiQ8WXT5. baseline.

Organism-specific databases

HPAiHPA012836.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366814.

Structurei

3D structure databases

ProteinModelPortaliQ8WXT5.
SMRiQ8WXT5. Positions 108-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 26757Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ8WXT5.
KOiK09397.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ8WXT5.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS
110 120 130 140 150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP
160 170 180 190 200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR
210 220 230 240 250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY
260 270 280 290 300
PNTAPGRRPY ALLHPHPLRY LLLSARVYAG APKKAEGADL ATPAPFPCCS
310 320 330 340 350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG
360 370 380 390 400
ATATCSSDHQ ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP
410
PRARCWAGTC RPRRRC
Length:416
Mass (Da):45,892
Last modified:September 11, 2007 - v2
Checksum:iCA8FCD2D09B5CBC8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti280 – 2801G → A in AAL73342 (PubMed:12234674).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343005 Genomic DNA. Translation: AAL73342.1.
BX284632 Genomic DNA. Translation: CAI14283.1.
CCDSiCCDS75845.1.
RefSeqiNP_954714.2. NM_199244.3.
UniGeneiHs.712520.

Genome annotation databases

EnsembliENST00000377413; ENSP00000366630; ENSG00000184659.
GeneIDi349334.
KEGGihsa:349334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343005 Genomic DNA. Translation: AAL73342.1.
BX284632 Genomic DNA. Translation: CAI14283.1.
CCDSiCCDS75845.1.
RefSeqiNP_954714.2. NM_199244.3.
UniGeneiHs.712520.

3D structure databases

ProteinModelPortaliQ8WXT5.
SMRiQ8WXT5. Positions 108-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366814.

PTM databases

PhosphoSiteiQ8WXT5.

Polymorphism and mutation databases

DMDMi158518651.

Proteomic databases

PaxDbiQ8WXT5.
PRIDEiQ8WXT5.

Protocols and materials databases

DNASUi349334.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377413; ENSP00000366630; ENSG00000184659.
GeneIDi349334.
KEGGihsa:349334.

Organism-specific databases

CTDi349334.
GeneCardsiGC09M070427.
HGNCiHGNC:23762. FOXD4L4.
HPAiHPA012836.
neXtProtiNX_Q8WXT5.
PharmGKBiPA142671752.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ8WXT5.
KOiK09397.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ8WXT5.
TreeFamiTF316127.

Miscellaneous databases

GenomeRNAii349334.
NextBioi136087.
PROiQ8WXT5.

Gene expression databases

BgeeiQ8WXT5.
CleanExiHS_FOXD4L4.
ExpressionAtlasiQ8WXT5. baseline.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines."
    Freyaldenhoven B.S., Fried C., Wielckens K.
    Gene 294:131-140(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFX4L4_HUMAN
AccessioniPrimary (citable) accession number: Q8WXT5
Secondary accession number(s): Q5RIB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: September 11, 2007
Last modified: July 22, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.