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Q8WXS8

- ATS14_HUMAN

UniProt

Q8WXS8 - ATS14_HUMAN

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Protein
A disintegrin and metalloproteinase with thrombospondin motifs 14
Gene
ADAMTS14
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi398 – 3981Zinc; catalytic By similarity
Active sitei399 – 3991 By similarity
Metal bindingi402 – 4021Zinc; catalytic By similarity
Metal bindingi408 – 4081Zinc; catalytic By similarity

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. collagen catabolic process Source: UniProtKB-KW
  2. collagen fibril organization Source: Ensembl
  3. extracellular matrix organization Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Collagen degradation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_200626. O-glycosylation of TSR domain-containing proteins.

Protein family/group databases

MEROPSiM12.024.

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 14 (EC:3.4.24.-)
Short name:
ADAM-TS 14
Short name:
ADAM-TS14
Short name:
ADAMTS-14
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:14899. ADAMTS14.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24540.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Propeptidei23 – 252230 By similarity
PRO_0000029190Add
BLAST
Chaini253 – 1223971A disintegrin and metalloproteinase with thrombospondin motifs 14
PRO_0000029191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi336 ↔ 382 By similarity
Disulfide bondi376 ↔ 455 By similarity
Disulfide bondi415 ↔ 441 By similarity
Glycosylationi475 – 4751N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi482 ↔ 507 By similarity
Disulfide bondi493 ↔ 516 By similarity
Disulfide bondi502 ↔ 535 By similarity
Disulfide bondi529 ↔ 540 By similarity
Disulfide bondi564 ↔ 601 By similarity
Disulfide bondi568 ↔ 606 By similarity
Disulfide bondi579 ↔ 591 By similarity
Glycosylationi941 – 9411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi980 ↔ 1016 By similarity
Disulfide bondi984 ↔ 1021 By similarity
Disulfide bondi995 ↔ 1005 By similarity
Glycosylationi1027 – 10271N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase By similarity.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ8WXS8.
PRIDEiQ8WXS8.

PTM databases

PhosphoSiteiQ8WXS8.

Expressioni

Tissue specificityi

Expressed in retina and at low levels in brain, lung and placenta. High expression in fetal tissues.

Gene expression databases

BgeeiQ8WXS8.
CleanExiHS_ADAMTS14.
GenevestigatoriQ8WXS8.

Organism-specific databases

HPAiHPA034605.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362304.

Structurei

3D structure databases

ProteinModelPortaliQ8WXS8.
SMRiQ8WXS8. Positions 261-720.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 460202Peptidase M12B
Add
BLAST
Domaini461 – 55191Disintegrin
Add
BLAST
Domaini552 – 60756TSP type-1 1
Add
BLAST
Domaini847 – 90761TSP type-1 2
Add
BLAST
Domaini908 – 96760TSP type-1 3
Add
BLAST
Domaini968 – 102255TSP type-1 4
Add
BLAST
Domaini1059 – 109739PLAC
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni730 – 846117Spacer
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi608 – 729122Cys-rich
Add
BLAST
Compositional biasi875 – 8784Poly-Arg
Compositional biasi1100 – 1221122Pro-rich
Add
BLAST

Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix By similarity.

Sequence similaritiesi

Contains 1 disintegrin domain.
Contains 1 PLAC domain.
Contains 4 TSP type-1 domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG307411.
HOGENOMiHOG000034222.
HOVERGENiHBG004314.
KOiK08628.
OMAiLPSYDCL.
OrthoDBiEOG76HQ0N.
PhylomeDBiQ8WXS8.
TreeFamiTF313537.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 4 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform A (identifier: Q8WXS8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPLRALLSY LLPLHCALCA AAGSRTPELH LSGKLSDYGV TVPCSTDFRG     50
RFLSHVVSGP AAASAGSMVV DTPPTLPRHS SHLRVARSPL HPGGTLWPGR 100
VGRHSLYFNV TVFGKELHLR LRPNRRLVVP GSSVEWQEDF RELFRQPLRQ 150
ECVYTGGVTG MPGAAVAISN CDGLAGLIRT DSTDFFIEPL ERGQQEKEAS 200
GRTHVVYRRE AVQQEWAEPD GDLHNEAFGL GDLPNLLGLV GDQLGDTERK 250
RRHAKPGSYS IEVLLVVDDS VVRFHGKEHV QNYVLTLMNI VDEIYHDESL 300
GVHINIALVR LIMVGYRQSL SLIERGNPSR SLEQVCRWAH SQQRQDPSHA 350
EHHDHVVFLT RQDFGPSGYA PVTGMCHPLR SCALNHEDGF SSAFVIAHET 400
GHVLGMEHDG QGNGCADETS LGSVMAPLVQ AAFHRFHWSR CSKLELSRYL 450
PSYDCLLDDP FDPAWPQPPE LPGINYSMDE QCRFDFGSGY QTCLAFRTFE 500
PCKQLWCSHP DNPYFCKTKK GPPLDGTECA PGKWCFKGHC IWKSPEQTYG 550
QDGGWSSWTK FGSCSRSCGG GVRSRSRSCN NPSPAYGGRL CLGPMFEYQV 600
CNSEECPGTY EDFRAQQCAK RNSYYVHQNA KHSWVPYEPD DDAQKCELIC 650
QSADTGDVVF MNQVVHDGTR CSYRDPYSVC ARGECVPVGC DKEVGSMKAD 700
DKCGVCGGDN SHCRTVKGTL GKASKQAGAL KLVQIPAGAR HIQIEALEKS 750
PHRIVVKNQV TGSFILNPKG KEATSRTFTA MGLEWEDAVE DAKESLKTSG 800
PLPEAIAILA LPPTEGGPRS SLAYKYVIHE DLLPLIGSNN VLLEEMDTYE 850
WALKSWAPCS KACGGGIQFT KYGCRRRRDH HMVQRHLCDH KKRPKPIRRR 900
CNQHPCSQPV WVTEEWGACS RSCGKLGVQT RGIQCLLPLS NGTHKVMPAK 950
ACAGDRPEAR RPCLRVPCPA QWRLGAWSQC SATCGEGIQQ RQVVCRTNAN 1000
SLGHCEGDRP DTVQVCSLPA CGGNHQNSTV RADVWELGTP EGQWVPQSEP 1050
LHPINKISST EPCTGDRSVF CQMEVLDRYC SIPGYHRLCC VSCIKKASGP 1100
NPGPDPGPTS LPPFSTPGSP LPGPQDPADA AEPPGKPTGS EDHQHGRATQ 1150
LPGALDTSSP GTQHPFAPET PIPGASWSIS PTTPGGLPWG WTQTPTPVPE 1200
DKGQPGEDLR HPGTSLPAAS PVT 1223

Note: Produced by alternative promoter usage.

Length:1,223
Mass (Da):133,888
Last modified:January 11, 2011 - v2
Checksum:iEEF3229519B3170A
GO
Isoform B (identifier: Q8WXS8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Note: Produced by alternative promoter usage.

Show »
Length:1,156
Mass (Da):127,036
Checksum:i0EF756C57D635CAE
GO
Isoform C (identifier: Q8WXS8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     368-368: G → GMQG

Note: Produced by alternative splicing of isoform B.

Show »
Length:1,159
Mass (Da):127,353
Checksum:i7D7B58455B6BFF31
GO
Isoform D (identifier: Q8WXS8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-368: G → GMQG

Note: Produced by alternative splicing of isoform A.

Show »
Length:1,226
Mass (Da):134,205
Checksum:iD218E0655F1FAF55
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791R → C.
Corresponds to variant rs34022601 [ dbSNP | Ensembl ].
VAR_047837
Natural varianti590 – 5901L → P.3 Publications
Corresponds to variant rs10823607 [ dbSNP | Ensembl ].
VAR_047838
Natural varianti937 – 9371L → M.
Corresponds to variant rs12774070 [ dbSNP | Ensembl ].
VAR_047839
Natural varianti1017 – 10171S → N.
Corresponds to variant rs10999516 [ dbSNP | Ensembl ].
VAR_047840
Natural varianti1049 – 10491E → G.
Corresponds to variant rs4747096 [ dbSNP | Ensembl ].
VAR_047841

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6767Missing in isoform B and isoform C.
VSP_006958Add
BLAST
Alternative sequencei368 – 3681G → GMQG in isoform C and isoform D.
VSP_005501

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti868 – 8681Q → R in CAC87943. 1 Publication
Sequence conflicti884 – 8841Q → H in CAC87943. 1 Publication
Sequence conflicti901 – 9011C → S in CAC87943. 1 Publication
Sequence conflicti923 – 9231C → Y in CAC87943. 1 Publication
Sequence conflicti1024 – 10241N → S in CAC87943. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF358666 mRNA. Translation: AAL40229.1.
AJ345098 mRNA. Translation: CAC87943.1.
AL358817, AL355344 Genomic DNA. Translation: CAI13857.1.
AL358817, AL355344 Genomic DNA. Translation: CAI13858.1.
AL355344, AL358817 Genomic DNA. Translation: CAI41277.1.
AL355344, AL358817 Genomic DNA. Translation: CAI41278.1.
CH471083 Genomic DNA. Translation: EAW54409.1.
CH471083 Genomic DNA. Translation: EAW54410.1.
AF366351 mRNA. Translation: AAL79814.1.
CCDSiCCDS7306.1. [Q8WXS8-1]
CCDS7307.1. [Q8WXS8-4]
RefSeqiNP_542453.2. NM_080722.3. [Q8WXS8-1]
NP_631894.2. NM_139155.2. [Q8WXS8-4]
UniGeneiHs.352156.

Genome annotation databases

EnsembliENST00000373207; ENSP00000362303; ENSG00000138316. [Q8WXS8-1]
ENST00000373208; ENSP00000362304; ENSG00000138316. [Q8WXS8-4]
GeneIDi140766.
KEGGihsa:140766.
UCSCiuc001jrg.3. human. [Q8WXS8-4]
uc001jrh.3. human. [Q8WXS8-1]

Polymorphism databases

DMDMi317373325.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF358666 mRNA. Translation: AAL40229.1 .
AJ345098 mRNA. Translation: CAC87943.1 .
AL358817 , AL355344 Genomic DNA. Translation: CAI13857.1 .
AL358817 , AL355344 Genomic DNA. Translation: CAI13858.1 .
AL355344 , AL358817 Genomic DNA. Translation: CAI41277.1 .
AL355344 , AL358817 Genomic DNA. Translation: CAI41278.1 .
CH471083 Genomic DNA. Translation: EAW54409.1 .
CH471083 Genomic DNA. Translation: EAW54410.1 .
AF366351 mRNA. Translation: AAL79814.1 .
CCDSi CCDS7306.1. [Q8WXS8-1 ]
CCDS7307.1. [Q8WXS8-4 ]
RefSeqi NP_542453.2. NM_080722.3. [Q8WXS8-1 ]
NP_631894.2. NM_139155.2. [Q8WXS8-4 ]
UniGenei Hs.352156.

3D structure databases

ProteinModelPortali Q8WXS8.
SMRi Q8WXS8. Positions 261-720.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000362304.

Protein family/group databases

MEROPSi M12.024.

PTM databases

PhosphoSitei Q8WXS8.

Polymorphism databases

DMDMi 317373325.

Proteomic databases

PaxDbi Q8WXS8.
PRIDEi Q8WXS8.

Protocols and materials databases

DNASUi 140766.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373207 ; ENSP00000362303 ; ENSG00000138316 . [Q8WXS8-1 ]
ENST00000373208 ; ENSP00000362304 ; ENSG00000138316 . [Q8WXS8-4 ]
GeneIDi 140766.
KEGGi hsa:140766.
UCSCi uc001jrg.3. human. [Q8WXS8-4 ]
uc001jrh.3. human. [Q8WXS8-1 ]

Organism-specific databases

CTDi 140766.
GeneCardsi GC10P072432.
H-InvDB HIX0025921.
HGNCi HGNC:14899. ADAMTS14.
HPAi HPA034605.
MIMi 607506. gene.
neXtProti NX_Q8WXS8.
PharmGKBi PA24540.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307411.
HOGENOMi HOG000034222.
HOVERGENi HBG004314.
KOi K08628.
OMAi LPSYDCL.
OrthoDBi EOG76HQ0N.
PhylomeDBi Q8WXS8.
TreeFami TF313537.

Enzyme and pathway databases

Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_200626. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii 140766.
NextBioi 84365.
PROi Q8WXS8.
SOURCEi Search...

Gene expression databases

Bgeei Q8WXS8.
CleanExi HS_ADAMTS14.
Genevestigatori Q8WXS8.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
SMARTi SM00209. TSP1. 4 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 4 hits.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family."
    Bolz H., Ramirez A., von Brederlow B., Kubisch C.
    Biochim. Biophys. Acta 1522:221-225(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANT PRO-590.
  2. "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains."
    Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C.
    Gene 283:49-62(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANT PRO-590.
    Tissue: Fetal lung.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3."
    Colige A., Vandenberghe I., Thiry M., Lambert C.A., Van Beeumen J., Li S.-W., Prockop D.J., Lapiere C.M., Nusgens B.V.
    J. Biol. Chem. 277:5756-5766(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-1223 (ISOFORMS B; C AND D), ALTERNATIVE PROMOTER USAGE, VARIANT PRO-590.

Entry informationi

Entry nameiATS14_HUMAN
AccessioniPrimary (citable) accession number: Q8WXS8
Secondary accession number(s): Q5T4G0
, Q5T4G1, Q8TE55, Q8TEY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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