Q8WXS8 (ATS14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 14
Short name=ADAM-TS 14
Short name=ADAM-TS14
Short name=ADAMTS-14
EC=3.4.24.-

Gene names

Name:

ADAMTS14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	Expressed in retina and at low levels in brain, lung and placenta. High expression in fetal tissues.
Domain	The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix By similarity.
Post-translational modification	The precursor is cleaved by a furin endopeptidase By similarity. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.
Sequence similarities	Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 1 PLAC domain. Contains 4 TSP type-1 domains.

Ontologies

Keywords
Biological process	Collagen degradation
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Domain	Repeat Signal
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	collagen catabolic process Inferred from electronic annotation. Source: UniProtKB-KW collagen fibril organization Inferred from electronic annotation. Source: Compara extracellular matrix organization Traceable author statement. Source: Reactome proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Traceable author statement. Source: Reactome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform A (identifier: Q8WXS8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Produced by alternative promoter usage.

Isoform B (identifier: Q8WXS8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Note: Produced by alternative promoter usage.

Isoform C (identifier: Q8WXS8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     368-368: G → GMQG

Note: Produced by alternative splicing of isoform B.

Isoform D (identifier: Q8WXS8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     368-368: G → GMQG

Note: Produced by alternative splicing of isoform A.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 252	230	By similarity		PRO_0000029190
	Chain	253 – 1223	971	A disintegrin and metalloproteinase with thrombospondin motifs 14		PRO_0000029191
Regions
	Domain	259 – 460	202	Peptidase M12B
	Domain	461 – 551	91	Disintegrin
	Domain	552 – 607	56	TSP type-1 1
	Domain	847 – 907	61	TSP type-1 2
	Domain	908 – 967	60	TSP type-1 3
	Domain	968 – 1022	55	TSP type-1 4
	Domain	1059 – 1097	39	PLAC
	Region	730 – 846	117	Spacer
	Compositional bias	608 – 729	122	Cys-rich
	Compositional bias	875 – 878	4	Poly-Arg
	Compositional bias	1100 – 1221	122	Pro-rich
Sites
	Active site	399	1	By similarity
	Metal binding	398	1	Zinc; catalytic By similarity
	Metal binding	402	1	Zinc; catalytic By similarity
	Metal binding	408	1	Zinc; catalytic By similarity
Amino acid modifications
	Glycosylation	109	1	N-linked (GlcNAc...) Potential
	Glycosylation	475	1	N-linked (GlcNAc...) Potential
	Glycosylation	941	1	N-linked (GlcNAc...) Potential
	Glycosylation	1027	1	N-linked (GlcNAc...) Potential
	Disulfide bond	376 ↔ 455		By similarity
	Disulfide bond	415 ↔ 441		By similarity
	Disulfide bond	564 ↔ 601		By similarity
	Disulfide bond	568 ↔ 606		By similarity
	Disulfide bond	579 ↔ 591		By similarity
	Disulfide bond	980 ↔ 1016		By similarity
	Disulfide bond	984 ↔ 1021		By similarity
	Disulfide bond	995 ↔ 1005		By similarity
Natural variations
	Alternative sequence	1 – 67	67	Missing in isoform B and isoform C.		VSP_006958
	Alternative sequence	368	1	G → GMQG in isoform C and isoform D.		VSP_005501
	Natural variant	179	1	R → C. Corresponds to variant rs34022601 [ dbSNP | Ensembl ].		VAR_047837
	Natural variant	590	1	L → P. Ref.1 Ref.2 Ref.5 Corresponds to variant rs10823607 [ dbSNP | Ensembl ].		VAR_047838
	Natural variant	937	1	L → M. Corresponds to variant rs12774070 [ dbSNP | Ensembl ].		VAR_047839
	Natural variant	1017	1	S → N. Corresponds to variant rs10999516 [ dbSNP | Ensembl ].		VAR_047840
	Natural variant	1049	1	E → G. Corresponds to variant rs4747096 [ dbSNP | Ensembl ].		VAR_047841
Experimental info
	Sequence conflict	868	1	Q → R in CAC87943. Ref.2
	Sequence conflict	884	1	Q → H in CAC87943. Ref.2
	Sequence conflict	901	1	C → S in CAC87943. Ref.2
	Sequence conflict	923	1	C → Y in CAC87943. Ref.2
	Sequence conflict	1024	1	N → S in CAC87943. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified January 11, 2011. Version 2. Checksum: EEF3229519B3170A	FASTA	1,223	133,888
	10 20 30 40 50 60 MAPLRALLSY LLPLHCALCA AAGSRTPELH LSGKLSDYGV TVPCSTDFRG RFLSHVVSGP 70 80 90 100 110 120 AAASAGSMVV DTPPTLPRHS SHLRVARSPL HPGGTLWPGR VGRHSLYFNV TVFGKELHLR 130 140 150 160 170 180 LRPNRRLVVP GSSVEWQEDF RELFRQPLRQ ECVYTGGVTG MPGAAVAISN CDGLAGLIRT 190 200 210 220 230 240 DSTDFFIEPL ERGQQEKEAS GRTHVVYRRE AVQQEWAEPD GDLHNEAFGL GDLPNLLGLV 250 260 270 280 290 300 GDQLGDTERK RRHAKPGSYS IEVLLVVDDS VVRFHGKEHV QNYVLTLMNI VDEIYHDESL 310 320 330 340 350 360 GVHINIALVR LIMVGYRQSL SLIERGNPSR SLEQVCRWAH SQQRQDPSHA EHHDHVVFLT 370 380 390 400 410 420 RQDFGPSGYA PVTGMCHPLR SCALNHEDGF SSAFVIAHET GHVLGMEHDG QGNGCADETS 430 440 450 460 470 480 LGSVMAPLVQ AAFHRFHWSR CSKLELSRYL PSYDCLLDDP FDPAWPQPPE LPGINYSMDE 490 500 510 520 530 540 QCRFDFGSGY QTCLAFRTFE PCKQLWCSHP DNPYFCKTKK GPPLDGTECA PGKWCFKGHC 550 560 570 580 590 600 IWKSPEQTYG QDGGWSSWTK FGSCSRSCGG GVRSRSRSCN NPSPAYGGRL CLGPMFEYQV 610 620 630 640 650 660 CNSEECPGTY EDFRAQQCAK RNSYYVHQNA KHSWVPYEPD DDAQKCELIC QSADTGDVVF 670 680 690 700 710 720 MNQVVHDGTR CSYRDPYSVC ARGECVPVGC DKEVGSMKAD DKCGVCGGDN SHCRTVKGTL 730 740 750 760 770 780 GKASKQAGAL KLVQIPAGAR HIQIEALEKS PHRIVVKNQV TGSFILNPKG KEATSRTFTA 790 800 810 820 830 840 MGLEWEDAVE DAKESLKTSG PLPEAIAILA LPPTEGGPRS SLAYKYVIHE DLLPLIGSNN 850 860 870 880 890 900 VLLEEMDTYE WALKSWAPCS KACGGGIQFT KYGCRRRRDH HMVQRHLCDH KKRPKPIRRR 910 920 930 940 950 960 CNQHPCSQPV WVTEEWGACS RSCGKLGVQT RGIQCLLPLS NGTHKVMPAK ACAGDRPEAR 970 980 990 1000 1010 1020 RPCLRVPCPA QWRLGAWSQC SATCGEGIQQ RQVVCRTNAN SLGHCEGDRP DTVQVCSLPA 1030 1040 1050 1060 1070 1080 CGGNHQNSTV RADVWELGTP EGQWVPQSEP LHPINKISST EPCTGDRSVF CQMEVLDRYC 1090 1100 1110 1120 1130 1140 SIPGYHRLCC VSCIKKASGP NPGPDPGPTS LPPFSTPGSP LPGPQDPADA AEPPGKPTGS 1150 1160 1170 1180 1190 1200 EDHQHGRATQ LPGALDTSSP GTQHPFAPET PIPGASWSIS PTTPGGLPWG WTQTPTPVPE 1210 1220 DKGQPGEDLR HPGTSLPAAS PVT
	Isoform B [UniParc]. Checksum: 0EF756C57D635CAE	FASTA	1,156	127,036
	10 20 30 40 50 60 MVVDTPPTLP RHSSHLRVAR SPLHPGGTLW PGRVGRHSLY FNVTVFGKEL HLRLRPNRRL 70 80 90 100 110 120 VVPGSSVEWQ EDFRELFRQP LRQECVYTGG VTGMPGAAVA ISNCDGLAGL IRTDSTDFFI 130 140 150 160 170 180 EPLERGQQEK EASGRTHVVY RREAVQQEWA EPDGDLHNEA FGLGDLPNLL GLVGDQLGDT 190 200 210 220 230 240 ERKRRHAKPG SYSIEVLLVV DDSVVRFHGK EHVQNYVLTL MNIVDEIYHD ESLGVHINIA 250 260 270 280 290 300 LVRLIMVGYR QSLSLIERGN PSRSLEQVCR WAHSQQRQDP SHAEHHDHVV FLTRQDFGPS 310 320 330 340 350 360 GYAPVTGMCH PLRSCALNHE DGFSSAFVIA HETGHVLGME HDGQGNGCAD ETSLGSVMAP 370 380 390 400 410 420 LVQAAFHRFH WSRCSKLELS RYLPSYDCLL DDPFDPAWPQ PPELPGINYS MDEQCRFDFG 430 440 450 460 470 480 SGYQTCLAFR TFEPCKQLWC SHPDNPYFCK TKKGPPLDGT ECAPGKWCFK GHCIWKSPEQ 490 500 510 520 530 540 TYGQDGGWSS WTKFGSCSRS CGGGVRSRSR SCNNPSPAYG GRLCLGPMFE YQVCNSEECP 550 560 570 580 590 600 GTYEDFRAQQ CAKRNSYYVH QNAKHSWVPY EPDDDAQKCE LICQSADTGD VVFMNQVVHD 610 620 630 640 650 660 GTRCSYRDPY SVCARGECVP VGCDKEVGSM KADDKCGVCG GDNSHCRTVK GTLGKASKQA 670 680 690 700 710 720 GALKLVQIPA GARHIQIEAL EKSPHRIVVK NQVTGSFILN PKGKEATSRT FTAMGLEWED 730 740 750 760 770 780 AVEDAKESLK TSGPLPEAIA ILALPPTEGG PRSSLAYKYV IHEDLLPLIG SNNVLLEEMD 790 800 810 820 830 840 TYEWALKSWA PCSKACGGGI QFTKYGCRRR RDHHMVQRHL CDHKKRPKPI RRRCNQHPCS 850 860 870 880 890 900 QPVWVTEEWG ACSRSCGKLG VQTRGIQCLL PLSNGTHKVM PAKACAGDRP EARRPCLRVP 910 920 930 940 950 960 CPAQWRLGAW SQCSATCGEG IQQRQVVCRT NANSLGHCEG DRPDTVQVCS LPACGGNHQN 970 980 990 1000 1010 1020 STVRADVWEL GTPEGQWVPQ SEPLHPINKI SSTEPCTGDR SVFCQMEVLD RYCSIPGYHR 1030 1040 1050 1060 1070 1080 LCCVSCIKKA SGPNPGPDPG PTSLPPFSTP GSPLPGPQDP ADAAEPPGKP TGSEDHQHGR 1090 1100 1110 1120 1130 1140 ATQLPGALDT SSPGTQHPFA PETPIPGASW SISPTTPGGL PWGWTQTPTP VPEDKGQPGE 1150 DLRHPGTSLP AASPVT
	Isoform C [UniParc]. Checksum: 7D7B58455B6BFF31	FASTA	1,159	127,353
	10 20 30 40 50 60 MVVDTPPTLP RHSSHLRVAR SPLHPGGTLW PGRVGRHSLY FNVTVFGKEL HLRLRPNRRL 70 80 90 100 110 120 VVPGSSVEWQ EDFRELFRQP LRQECVYTGG VTGMPGAAVA ISNCDGLAGL IRTDSTDFFI 130 140 150 160 170 180 EPLERGQQEK EASGRTHVVY RREAVQQEWA EPDGDLHNEA FGLGDLPNLL GLVGDQLGDT 190 200 210 220 230 240 ERKRRHAKPG SYSIEVLLVV DDSVVRFHGK EHVQNYVLTL MNIVDEIYHD ESLGVHINIA 250 260 270 280 290 300 LVRLIMVGYR QSLSLIERGN PSRSLEQVCR WAHSQQRQDP SHAEHHDHVV FLTRQDFGPS 310 320 330 340 350 360 GMQGYAPVTG MCHPLRSCAL NHEDGFSSAF VIAHETGHVL GMEHDGQGNG CADETSLGSV 370 380 390 400 410 420 MAPLVQAAFH RFHWSRCSKL ELSRYLPSYD CLLDDPFDPA WPQPPELPGI NYSMDEQCRF 430 440 450 460 470 480 DFGSGYQTCL AFRTFEPCKQ LWCSHPDNPY FCKTKKGPPL DGTECAPGKW CFKGHCIWKS 490 500 510 520 530 540 PEQTYGQDGG WSSWTKFGSC SRSCGGGVRS RSRSCNNPSP AYGGRLCLGP MFEYQVCNSE 550 560 570 580 590 600 ECPGTYEDFR AQQCAKRNSY YVHQNAKHSW VPYEPDDDAQ KCELICQSAD TGDVVFMNQV 610 620 630 640 650 660 VHDGTRCSYR DPYSVCARGE CVPVGCDKEV GSMKADDKCG VCGGDNSHCR TVKGTLGKAS 670 680 690 700 710 720 KQAGALKLVQ IPAGARHIQI EALEKSPHRI VVKNQVTGSF ILNPKGKEAT SRTFTAMGLE 730 740 750 760 770 780 WEDAVEDAKE SLKTSGPLPE AIAILALPPT EGGPRSSLAY KYVIHEDLLP LIGSNNVLLE 790 800 810 820 830 840 EMDTYEWALK SWAPCSKACG GGIQFTKYGC RRRRDHHMVQ RHLCDHKKRP KPIRRRCNQH 850 860 870 880 890 900 PCSQPVWVTE EWGACSRSCG KLGVQTRGIQ CLLPLSNGTH KVMPAKACAG DRPEARRPCL 910 920 930 940 950 960 RVPCPAQWRL GAWSQCSATC GEGIQQRQVV CRTNANSLGH CEGDRPDTVQ VCSLPACGGN 970 980 990 1000 1010 1020 HQNSTVRADV WELGTPEGQW VPQSEPLHPI NKISSTEPCT GDRSVFCQME VLDRYCSIPG 1030 1040 1050 1060 1070 1080 YHRLCCVSCI KKASGPNPGP DPGPTSLPPF STPGSPLPGP QDPADAAEPP GKPTGSEDHQ 1090 1100 1110 1120 1130 1140 HGRATQLPGA LDTSSPGTQH PFAPETPIPG ASWSISPTTP GGLPWGWTQT PTPVPEDKGQ 1150 PGEDLRHPGT SLPAASPVT
	Isoform D [UniParc]. Checksum: D218E0655F1FAF55	FASTA	1,226	134,205
	10 20 30 40 50 60 MAPLRALLSY LLPLHCALCA AAGSRTPELH LSGKLSDYGV TVPCSTDFRG RFLSHVVSGP 70 80 90 100 110 120 AAASAGSMVV DTPPTLPRHS SHLRVARSPL HPGGTLWPGR VGRHSLYFNV TVFGKELHLR 130 140 150 160 170 180 LRPNRRLVVP GSSVEWQEDF RELFRQPLRQ ECVYTGGVTG MPGAAVAISN CDGLAGLIRT 190 200 210 220 230 240 DSTDFFIEPL ERGQQEKEAS GRTHVVYRRE AVQQEWAEPD GDLHNEAFGL GDLPNLLGLV 250 260 270 280 290 300 GDQLGDTERK RRHAKPGSYS IEVLLVVDDS VVRFHGKEHV QNYVLTLMNI VDEIYHDESL 310 320 330 340 350 360 GVHINIALVR LIMVGYRQSL SLIERGNPSR SLEQVCRWAH SQQRQDPSHA EHHDHVVFLT 370 380 390 400 410 420 RQDFGPSGMQ GYAPVTGMCH PLRSCALNHE DGFSSAFVIA HETGHVLGME HDGQGNGCAD 430 440 450 460 470 480 ETSLGSVMAP LVQAAFHRFH WSRCSKLELS RYLPSYDCLL DDPFDPAWPQ PPELPGINYS 490 500 510 520 530 540 MDEQCRFDFG SGYQTCLAFR TFEPCKQLWC SHPDNPYFCK TKKGPPLDGT ECAPGKWCFK 550 560 570 580 590 600 GHCIWKSPEQ TYGQDGGWSS WTKFGSCSRS CGGGVRSRSR SCNNPSPAYG GRLCLGPMFE 610 620 630 640 650 660 YQVCNSEECP GTYEDFRAQQ CAKRNSYYVH QNAKHSWVPY EPDDDAQKCE LICQSADTGD 670 680 690 700 710 720 VVFMNQVVHD GTRCSYRDPY SVCARGECVP VGCDKEVGSM KADDKCGVCG GDNSHCRTVK 730 740 750 760 770 780 GTLGKASKQA GALKLVQIPA GARHIQIEAL EKSPHRIVVK NQVTGSFILN PKGKEATSRT 790 800 810 820 830 840 FTAMGLEWED AVEDAKESLK TSGPLPEAIA ILALPPTEGG PRSSLAYKYV IHEDLLPLIG 850 860 870 880 890 900 SNNVLLEEMD TYEWALKSWA PCSKACGGGI QFTKYGCRRR RDHHMVQRHL CDHKKRPKPI 910 920 930 940 950 960 RRRCNQHPCS QPVWVTEEWG ACSRSCGKLG VQTRGIQCLL PLSNGTHKVM PAKACAGDRP 970 980 990 1000 1010 1020 EARRPCLRVP CPAQWRLGAW SQCSATCGEG IQQRQVVCRT NANSLGHCEG DRPDTVQVCS 1030 1040 1050 1060 1070 1080 LPACGGNHQN STVRADVWEL GTPEGQWVPQ SEPLHPINKI SSTEPCTGDR SVFCQMEVLD 1090 1100 1110 1120 1130 1140 RYCSIPGYHR LCCVSCIKKA SGPNPGPDPG PTSLPPFSTP GSPLPGPQDP ADAAEPPGKP 1150 1160 1170 1180 1190 1200 TGSEDHQHGR ATQLPGALDT SSPGTQHPFA PETPIPGASW SISPTTPGGL PWGWTQTPTP 1210 1220 VPEDKGQPGE DLRHPGTSLP AASPVT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family." Bolz H., Ramirez A., von Brederlow B., Kubisch C. Biochim. Biophys. Acta 1522:221-225(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANT PRO-590.
[2]	"Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains." Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C. Gene 283:49-62(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANT PRO-590. Tissue: Fetal lung.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3." Colige A., Vandenberghe I., Thiry M., Lambert C.A., Van Beeumen J., Li S.-W., Prockop D.J., Lapiere C.M., Nusgens B.V. J. Biol. Chem. 277:5756-5766(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-1223 (ISOFORMS B; C AND D), ALTERNATIVE PROMOTER USAGE, VARIANT PRO-590.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF358666 mRNA. Translation: AAL40229.1. AJ345098 mRNA. Translation: CAC87943.1. AL358817, AL355344 Genomic DNA. Translation: CAI13857.1. AL358817, AL355344 Genomic DNA. Translation: CAI13858.1. AL355344, AL358817 Genomic DNA. Translation: CAI41277.1. AL355344, AL358817 Genomic DNA. Translation: CAI41278.1. CH471083 Genomic DNA. Translation: EAW54409.1. CH471083 Genomic DNA. Translation: EAW54410.1. AF366351 mRNA. Translation: AAL79814.1.
IPI	IPI00103606. IPI00219596. IPI00219597. IPI00219598.
RefSeq	NP_542453.2. NM_080722.3. NP_631894.2. NM_139155.2.
UniGene	Hs.352156.
3D structure databases
ProteinModelPortal	Q8WXS8.
SMR	Q8WXS8. Positions 261-830, 853-908, 913-970, 974-1024.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000362304.
Protein family/group databases
MEROPS	M12.024.
PTM databases
PhosphoSite	Q8WXS8.
Polymorphism databases
DMDM	29337086.
Proteomic databases
PaxDb	Q8WXS8.
PRIDE	Q8WXS8.
Protocols and materials databases
DNASU	140766.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373207; ENSP00000362303; ENSG00000138316. ENST00000373208; ENSP00000362304; ENSG00000138316.
GeneID	140766.
KEGG	hsa:140766.
UCSC	uc001jrh.3. human.
Organism-specific databases
CTD	140766.
GeneCards	GC10P072432.
H-InvDB	HIX0025921.
HGNC	HGNC:14899. ADAMTS14.
HPA	HPA034605.
MIM	607506. gene.
neXtProt	NX_Q8WXS8.
PharmGKB	PA24540.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG307411.
HOGENOM	HOG000034222.
HOVERGEN	HBG004314.
KO	K08628.
OMA	SRYLPSY.
Enzyme and pathway databases
Reactome	REACT_118779. Extracellular matrix organization.
Gene expression databases
ArrayExpress	Q8WXS8.
Bgee	Q8WXS8.
CleanEx	HS_ADAMTS14.
Genevestigator	Q8WXS8.
GermOnline	ENSG00000138316. Homo sapiens.
Family and domain databases
Gene3D	3.40.390.10. 1 hit.
InterPro	IPR010294. ADAM_spacer1. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR013273. Peptidase_M12B_ADAM-TS. IPR002870. Peptidase_M12B_N. IPR010909. PLAC. IPR000884. Thrombospondin_1_rpt. [Graphical view]
Pfam	PF05986. ADAM_spacer1. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. PF00090. TSP_1. 4 hits. [Graphical view]
PRINTS	PR01857. ADAMTSFAMILY.
SMART	SM00209. TSP1. 4 hits. [Graphical view]
SUPFAM	SSF82895. TSP1. 4 hits.
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00546. CYSTEINE_SWITCH. False negative. PS00427. DISINTEGRIN_1. False negative. PS50214. DISINTEGRIN_2. False negative. PS50900. PLAC. 1 hit. PS50092. TSP1. 4 hits. PS00142. ZINC_PROTEASE. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	140766.
NextBio	84365.
SOURCE	Search...

Entry information

Entry name

ATS14_HUMAN

Accession

Primary (citable) accession number: Q8WXS8
Secondary accession number(s): Q5T4G0 , Q5T4G1, Q8TE55, Q8TEY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.