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Q8WXS8

- ATS14_HUMAN

UniProt

Q8WXS8 - ATS14_HUMAN

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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 14

Gene

ADAMTS14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi398 – 3981Zinc; catalyticPROSITE-ProRule annotation
Active sitei399 – 3991PROSITE-ProRule annotation
Metal bindingi402 – 4021Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi408 – 4081Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. collagen catabolic process Source: UniProtKB-KW
  2. collagen fibril organization Source: Ensembl
  3. extracellular matrix organization Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Collagen degradation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_200626. O-glycosylation of TSR domain-containing proteins.

Protein family/group databases

MEROPSiM12.024.

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 14 (EC:3.4.24.-)
Short name:
ADAM-TS 14
Short name:
ADAM-TS14
Short name:
ADAMTS-14
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:14899. ADAMTS14.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24540.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 252230By similarityPRO_0000029190Add
BLAST
Chaini253 – 1223971A disintegrin and metalloproteinase with thrombospondin motifs 14PRO_0000029191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi336 ↔ 382By similarity
Disulfide bondi376 ↔ 455By similarity
Disulfide bondi415 ↔ 441By similarity
Glycosylationi475 – 4751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi482 ↔ 507By similarity
Disulfide bondi493 ↔ 516By similarity
Disulfide bondi502 ↔ 535By similarity
Disulfide bondi529 ↔ 540By similarity
Disulfide bondi564 ↔ 601By similarity
Disulfide bondi568 ↔ 606By similarity
Disulfide bondi579 ↔ 591By similarity
Glycosylationi941 – 9411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi980 ↔ 1016By similarity
Disulfide bondi984 ↔ 1021By similarity
Disulfide bondi995 ↔ 1005By similarity
Glycosylationi1027 – 10271N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ8WXS8.
PRIDEiQ8WXS8.

PTM databases

PhosphoSiteiQ8WXS8.

Expressioni

Tissue specificityi

Expressed in retina and at low levels in brain, lung and placenta. High expression in fetal tissues.

Gene expression databases

BgeeiQ8WXS8.
CleanExiHS_ADAMTS14.
GenevestigatoriQ8WXS8.

Organism-specific databases

HPAiHPA034605.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362304.

Structurei

3D structure databases

ProteinModelPortaliQ8WXS8.
SMRiQ8WXS8. Positions 261-720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 460202Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini461 – 55191DisintegrinAdd
BLAST
Domaini552 – 60756TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini847 – 90761TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini908 – 96760TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini968 – 102255TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini1059 – 109739PLACPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni730 – 846117SpacerAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi608 – 729122Cys-richAdd
BLAST
Compositional biasi875 – 8784Poly-Arg
Compositional biasi1100 – 1221122Pro-richAdd
BLAST

Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity

Sequence similaritiesi

Contains 1 disintegrin domain.Curated
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation
Contains 1 PLAC domain.PROSITE-ProRule annotation
Contains 4 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG307411.
GeneTreeiENSGT00760000118880.
HOGENOMiHOG000034222.
HOVERGENiHBG004314.
InParanoidiQ8WXS8.
KOiK08628.
OMAiLPSYDCL.
OrthoDBiEOG76HQ0N.
PhylomeDBiQ8WXS8.
TreeFamiTF313537.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 4 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform A (identifier: Q8WXS8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPLRALLSY LLPLHCALCA AAGSRTPELH LSGKLSDYGV TVPCSTDFRG
60 70 80 90 100
RFLSHVVSGP AAASAGSMVV DTPPTLPRHS SHLRVARSPL HPGGTLWPGR
110 120 130 140 150
VGRHSLYFNV TVFGKELHLR LRPNRRLVVP GSSVEWQEDF RELFRQPLRQ
160 170 180 190 200
ECVYTGGVTG MPGAAVAISN CDGLAGLIRT DSTDFFIEPL ERGQQEKEAS
210 220 230 240 250
GRTHVVYRRE AVQQEWAEPD GDLHNEAFGL GDLPNLLGLV GDQLGDTERK
260 270 280 290 300
RRHAKPGSYS IEVLLVVDDS VVRFHGKEHV QNYVLTLMNI VDEIYHDESL
310 320 330 340 350
GVHINIALVR LIMVGYRQSL SLIERGNPSR SLEQVCRWAH SQQRQDPSHA
360 370 380 390 400
EHHDHVVFLT RQDFGPSGYA PVTGMCHPLR SCALNHEDGF SSAFVIAHET
410 420 430 440 450
GHVLGMEHDG QGNGCADETS LGSVMAPLVQ AAFHRFHWSR CSKLELSRYL
460 470 480 490 500
PSYDCLLDDP FDPAWPQPPE LPGINYSMDE QCRFDFGSGY QTCLAFRTFE
510 520 530 540 550
PCKQLWCSHP DNPYFCKTKK GPPLDGTECA PGKWCFKGHC IWKSPEQTYG
560 570 580 590 600
QDGGWSSWTK FGSCSRSCGG GVRSRSRSCN NPSPAYGGRL CLGPMFEYQV
610 620 630 640 650
CNSEECPGTY EDFRAQQCAK RNSYYVHQNA KHSWVPYEPD DDAQKCELIC
660 670 680 690 700
QSADTGDVVF MNQVVHDGTR CSYRDPYSVC ARGECVPVGC DKEVGSMKAD
710 720 730 740 750
DKCGVCGGDN SHCRTVKGTL GKASKQAGAL KLVQIPAGAR HIQIEALEKS
760 770 780 790 800
PHRIVVKNQV TGSFILNPKG KEATSRTFTA MGLEWEDAVE DAKESLKTSG
810 820 830 840 850
PLPEAIAILA LPPTEGGPRS SLAYKYVIHE DLLPLIGSNN VLLEEMDTYE
860 870 880 890 900
WALKSWAPCS KACGGGIQFT KYGCRRRRDH HMVQRHLCDH KKRPKPIRRR
910 920 930 940 950
CNQHPCSQPV WVTEEWGACS RSCGKLGVQT RGIQCLLPLS NGTHKVMPAK
960 970 980 990 1000
ACAGDRPEAR RPCLRVPCPA QWRLGAWSQC SATCGEGIQQ RQVVCRTNAN
1010 1020 1030 1040 1050
SLGHCEGDRP DTVQVCSLPA CGGNHQNSTV RADVWELGTP EGQWVPQSEP
1060 1070 1080 1090 1100
LHPINKISST EPCTGDRSVF CQMEVLDRYC SIPGYHRLCC VSCIKKASGP
1110 1120 1130 1140 1150
NPGPDPGPTS LPPFSTPGSP LPGPQDPADA AEPPGKPTGS EDHQHGRATQ
1160 1170 1180 1190 1200
LPGALDTSSP GTQHPFAPET PIPGASWSIS PTTPGGLPWG WTQTPTPVPE
1210 1220
DKGQPGEDLR HPGTSLPAAS PVT

Note: Produced by alternative promoter usage.

Length:1,223
Mass (Da):133,888
Last modified:January 11, 2011 - v2
Checksum:iEEF3229519B3170A
GO
Isoform B (identifier: Q8WXS8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Note: Produced by alternative promoter usage.

Show »
Length:1,156
Mass (Da):127,036
Checksum:i0EF756C57D635CAE
GO
Isoform C (identifier: Q8WXS8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     368-368: G → GMQG

Note: Produced by alternative splicing of isoform B.

Show »
Length:1,159
Mass (Da):127,353
Checksum:i7D7B58455B6BFF31
GO
Isoform D (identifier: Q8WXS8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-368: G → GMQG

Note: Produced by alternative splicing of isoform A.

Show »
Length:1,226
Mass (Da):134,205
Checksum:iD218E0655F1FAF55
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti868 – 8681Q → R in CAC87943. (PubMed:11867212)Curated
Sequence conflicti884 – 8841Q → H in CAC87943. (PubMed:11867212)Curated
Sequence conflicti901 – 9011C → S in CAC87943. (PubMed:11867212)Curated
Sequence conflicti923 – 9231C → Y in CAC87943. (PubMed:11867212)Curated
Sequence conflicti1024 – 10241N → S in CAC87943. (PubMed:11867212)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791R → C.
Corresponds to variant rs34022601 [ dbSNP | Ensembl ].
VAR_047837
Natural varianti590 – 5901L → P.3 Publications
Corresponds to variant rs10823607 [ dbSNP | Ensembl ].
VAR_047838
Natural varianti937 – 9371L → M.
Corresponds to variant rs12774070 [ dbSNP | Ensembl ].
VAR_047839
Natural varianti1017 – 10171S → N.
Corresponds to variant rs10999516 [ dbSNP | Ensembl ].
VAR_047840
Natural varianti1049 – 10491E → G.
Corresponds to variant rs4747096 [ dbSNP | Ensembl ].
VAR_047841

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6767Missing in isoform B and isoform C. 1 PublicationVSP_006958Add
BLAST
Alternative sequencei368 – 3681G → GMQG in isoform C and isoform D. 1 PublicationVSP_005501

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF358666 mRNA. Translation: AAL40229.1.
AJ345098 mRNA. Translation: CAC87943.1.
AL358817, AL355344 Genomic DNA. Translation: CAI13857.1.
AL358817, AL355344 Genomic DNA. Translation: CAI13858.1.
AL355344, AL358817 Genomic DNA. Translation: CAI41277.1.
AL355344, AL358817 Genomic DNA. Translation: CAI41278.1.
CH471083 Genomic DNA. Translation: EAW54409.1.
CH471083 Genomic DNA. Translation: EAW54410.1.
AF366351 mRNA. Translation: AAL79814.1.
CCDSiCCDS7306.1. [Q8WXS8-1]
CCDS7307.1. [Q8WXS8-4]
RefSeqiNP_542453.2. NM_080722.3. [Q8WXS8-1]
NP_631894.2. NM_139155.2. [Q8WXS8-4]
UniGeneiHs.352156.

Genome annotation databases

EnsembliENST00000373207; ENSP00000362303; ENSG00000138316. [Q8WXS8-1]
ENST00000373208; ENSP00000362304; ENSG00000138316. [Q8WXS8-4]
GeneIDi140766.
KEGGihsa:140766.
UCSCiuc001jrg.3. human. [Q8WXS8-4]
uc001jrh.3. human. [Q8WXS8-1]

Polymorphism databases

DMDMi317373325.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF358666 mRNA. Translation: AAL40229.1 .
AJ345098 mRNA. Translation: CAC87943.1 .
AL358817 , AL355344 Genomic DNA. Translation: CAI13857.1 .
AL358817 , AL355344 Genomic DNA. Translation: CAI13858.1 .
AL355344 , AL358817 Genomic DNA. Translation: CAI41277.1 .
AL355344 , AL358817 Genomic DNA. Translation: CAI41278.1 .
CH471083 Genomic DNA. Translation: EAW54409.1 .
CH471083 Genomic DNA. Translation: EAW54410.1 .
AF366351 mRNA. Translation: AAL79814.1 .
CCDSi CCDS7306.1. [Q8WXS8-1 ]
CCDS7307.1. [Q8WXS8-4 ]
RefSeqi NP_542453.2. NM_080722.3. [Q8WXS8-1 ]
NP_631894.2. NM_139155.2. [Q8WXS8-4 ]
UniGenei Hs.352156.

3D structure databases

ProteinModelPortali Q8WXS8.
SMRi Q8WXS8. Positions 261-720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000362304.

Protein family/group databases

MEROPSi M12.024.

PTM databases

PhosphoSitei Q8WXS8.

Polymorphism databases

DMDMi 317373325.

Proteomic databases

PaxDbi Q8WXS8.
PRIDEi Q8WXS8.

Protocols and materials databases

DNASUi 140766.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373207 ; ENSP00000362303 ; ENSG00000138316 . [Q8WXS8-1 ]
ENST00000373208 ; ENSP00000362304 ; ENSG00000138316 . [Q8WXS8-4 ]
GeneIDi 140766.
KEGGi hsa:140766.
UCSCi uc001jrg.3. human. [Q8WXS8-4 ]
uc001jrh.3. human. [Q8WXS8-1 ]

Organism-specific databases

CTDi 140766.
GeneCardsi GC10P072432.
H-InvDB HIX0025921.
HGNCi HGNC:14899. ADAMTS14.
HPAi HPA034605.
MIMi 607506. gene.
neXtProti NX_Q8WXS8.
PharmGKBi PA24540.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307411.
GeneTreei ENSGT00760000118880.
HOGENOMi HOG000034222.
HOVERGENi HBG004314.
InParanoidi Q8WXS8.
KOi K08628.
OMAi LPSYDCL.
OrthoDBi EOG76HQ0N.
PhylomeDBi Q8WXS8.
TreeFami TF313537.

Enzyme and pathway databases

Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_200626. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii 140766.
NextBioi 84365.
PROi Q8WXS8.
SOURCEi Search...

Gene expression databases

Bgeei Q8WXS8.
CleanExi HS_ADAMTS14.
Genevestigatori Q8WXS8.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
SMARTi SM00209. TSP1. 4 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 4 hits.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family."
    Bolz H., Ramirez A., von Brederlow B., Kubisch C.
    Biochim. Biophys. Acta 1522:221-225(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANT PRO-590.
  2. "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains."
    Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C.
    Gene 283:49-62(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANT PRO-590.
    Tissue: Fetal lung.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3."
    Colige A., Vandenberghe I., Thiry M., Lambert C.A., Van Beeumen J., Li S.-W., Prockop D.J., Lapiere C.M., Nusgens B.V.
    J. Biol. Chem. 277:5756-5766(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-1223 (ISOFORMS B; C AND D), ALTERNATIVE PROMOTER USAGE, VARIANT PRO-590.

Entry informationi

Entry nameiATS14_HUMAN
AccessioniPrimary (citable) accession number: Q8WXS8
Secondary accession number(s): Q5T4G0
, Q5T4G1, Q8TE55, Q8TEY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3