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Q8WXS8

- ATS14_HUMAN

UniProt

Q8WXS8 - ATS14_HUMAN

Protein

A disintegrin and metalloproteinase with thrombospondin motifs 14

Gene

ADAMTS14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi398 – 3981Zinc; catalyticPROSITE-ProRule annotation
    Active sitei399 – 3991PROSITE-ProRule annotation
    Metal bindingi402 – 4021Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi408 – 4081Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. collagen catabolic process Source: UniProtKB-KW
    2. collagen fibril organization Source: Ensembl
    3. extracellular matrix organization Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Collagen degradation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_200626. O-glycosylation of TSR domain-containing proteins.

    Protein family/group databases

    MEROPSiM12.024.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 14 (EC:3.4.24.-)
    Short name:
    ADAM-TS 14
    Short name:
    ADAM-TS14
    Short name:
    ADAMTS-14
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:14899. ADAMTS14.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24540.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 252230By similarityPRO_0000029190Add
    BLAST
    Chaini253 – 1223971A disintegrin and metalloproteinase with thrombospondin motifs 14PRO_0000029191Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi336 ↔ 382By similarity
    Disulfide bondi376 ↔ 455By similarity
    Disulfide bondi415 ↔ 441By similarity
    Glycosylationi475 – 4751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi482 ↔ 507By similarity
    Disulfide bondi493 ↔ 516By similarity
    Disulfide bondi502 ↔ 535By similarity
    Disulfide bondi529 ↔ 540By similarity
    Disulfide bondi564 ↔ 601By similarity
    Disulfide bondi568 ↔ 606By similarity
    Disulfide bondi579 ↔ 591By similarity
    Glycosylationi941 – 9411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi980 ↔ 1016By similarity
    Disulfide bondi984 ↔ 1021By similarity
    Disulfide bondi995 ↔ 1005By similarity
    Glycosylationi1027 – 10271N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The precursor is cleaved by a furin endopeptidase.By similarity
    Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ8WXS8.
    PRIDEiQ8WXS8.

    PTM databases

    PhosphoSiteiQ8WXS8.

    Expressioni

    Tissue specificityi

    Expressed in retina and at low levels in brain, lung and placenta. High expression in fetal tissues.

    Gene expression databases

    BgeeiQ8WXS8.
    CleanExiHS_ADAMTS14.
    GenevestigatoriQ8WXS8.

    Organism-specific databases

    HPAiHPA034605.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000362304.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXS8.
    SMRiQ8WXS8. Positions 261-720.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini259 – 460202Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini461 – 55191DisintegrinAdd
    BLAST
    Domaini552 – 60756TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini847 – 90761TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini908 – 96760TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini968 – 102255TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1059 – 109739PLACPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni730 – 846117SpacerAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi608 – 729122Cys-richAdd
    BLAST
    Compositional biasi875 – 8784Poly-Arg
    Compositional biasi1100 – 1221122Pro-richAdd
    BLAST

    Domaini

    The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity

    Sequence similaritiesi

    Contains 1 disintegrin domain.Curated
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation
    Contains 1 PLAC domain.PROSITE-ProRule annotation
    Contains 4 TSP type-1 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG307411.
    HOGENOMiHOG000034222.
    HOVERGENiHBG004314.
    KOiK08628.
    OMAiLPSYDCL.
    OrthoDBiEOG76HQ0N.
    PhylomeDBiQ8WXS8.
    TreeFamiTF313537.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    InterProiIPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR010909. PLAC.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 4 hits.
    [Graphical view]
    PRINTSiPR01857. ADAMTSFAMILY.
    SMARTiSM00209. TSP1. 4 hits.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 4 hits.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS50900. PLAC. 1 hit.
    PS50092. TSP1. 4 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform A (identifier: Q8WXS8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPLRALLSY LLPLHCALCA AAGSRTPELH LSGKLSDYGV TVPCSTDFRG     50
    RFLSHVVSGP AAASAGSMVV DTPPTLPRHS SHLRVARSPL HPGGTLWPGR 100
    VGRHSLYFNV TVFGKELHLR LRPNRRLVVP GSSVEWQEDF RELFRQPLRQ 150
    ECVYTGGVTG MPGAAVAISN CDGLAGLIRT DSTDFFIEPL ERGQQEKEAS 200
    GRTHVVYRRE AVQQEWAEPD GDLHNEAFGL GDLPNLLGLV GDQLGDTERK 250
    RRHAKPGSYS IEVLLVVDDS VVRFHGKEHV QNYVLTLMNI VDEIYHDESL 300
    GVHINIALVR LIMVGYRQSL SLIERGNPSR SLEQVCRWAH SQQRQDPSHA 350
    EHHDHVVFLT RQDFGPSGYA PVTGMCHPLR SCALNHEDGF SSAFVIAHET 400
    GHVLGMEHDG QGNGCADETS LGSVMAPLVQ AAFHRFHWSR CSKLELSRYL 450
    PSYDCLLDDP FDPAWPQPPE LPGINYSMDE QCRFDFGSGY QTCLAFRTFE 500
    PCKQLWCSHP DNPYFCKTKK GPPLDGTECA PGKWCFKGHC IWKSPEQTYG 550
    QDGGWSSWTK FGSCSRSCGG GVRSRSRSCN NPSPAYGGRL CLGPMFEYQV 600
    CNSEECPGTY EDFRAQQCAK RNSYYVHQNA KHSWVPYEPD DDAQKCELIC 650
    QSADTGDVVF MNQVVHDGTR CSYRDPYSVC ARGECVPVGC DKEVGSMKAD 700
    DKCGVCGGDN SHCRTVKGTL GKASKQAGAL KLVQIPAGAR HIQIEALEKS 750
    PHRIVVKNQV TGSFILNPKG KEATSRTFTA MGLEWEDAVE DAKESLKTSG 800
    PLPEAIAILA LPPTEGGPRS SLAYKYVIHE DLLPLIGSNN VLLEEMDTYE 850
    WALKSWAPCS KACGGGIQFT KYGCRRRRDH HMVQRHLCDH KKRPKPIRRR 900
    CNQHPCSQPV WVTEEWGACS RSCGKLGVQT RGIQCLLPLS NGTHKVMPAK 950
    ACAGDRPEAR RPCLRVPCPA QWRLGAWSQC SATCGEGIQQ RQVVCRTNAN 1000
    SLGHCEGDRP DTVQVCSLPA CGGNHQNSTV RADVWELGTP EGQWVPQSEP 1050
    LHPINKISST EPCTGDRSVF CQMEVLDRYC SIPGYHRLCC VSCIKKASGP 1100
    NPGPDPGPTS LPPFSTPGSP LPGPQDPADA AEPPGKPTGS EDHQHGRATQ 1150
    LPGALDTSSP GTQHPFAPET PIPGASWSIS PTTPGGLPWG WTQTPTPVPE 1200
    DKGQPGEDLR HPGTSLPAAS PVT 1223

    Note: Produced by alternative promoter usage.

    Length:1,223
    Mass (Da):133,888
    Last modified:January 11, 2011 - v2
    Checksum:iEEF3229519B3170A
    GO
    Isoform B (identifier: Q8WXS8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-67: Missing.

    Note: Produced by alternative promoter usage.

    Show »
    Length:1,156
    Mass (Da):127,036
    Checksum:i0EF756C57D635CAE
    GO
    Isoform C (identifier: Q8WXS8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-67: Missing.
         368-368: G → GMQG

    Note: Produced by alternative splicing of isoform B.

    Show »
    Length:1,159
    Mass (Da):127,353
    Checksum:i7D7B58455B6BFF31
    GO
    Isoform D (identifier: Q8WXS8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         368-368: G → GMQG

    Note: Produced by alternative splicing of isoform A.

    Show »
    Length:1,226
    Mass (Da):134,205
    Checksum:iD218E0655F1FAF55
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti868 – 8681Q → R in CAC87943. (PubMed:11867212)Curated
    Sequence conflicti884 – 8841Q → H in CAC87943. (PubMed:11867212)Curated
    Sequence conflicti901 – 9011C → S in CAC87943. (PubMed:11867212)Curated
    Sequence conflicti923 – 9231C → Y in CAC87943. (PubMed:11867212)Curated
    Sequence conflicti1024 – 10241N → S in CAC87943. (PubMed:11867212)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti179 – 1791R → C.
    Corresponds to variant rs34022601 [ dbSNP | Ensembl ].
    VAR_047837
    Natural varianti590 – 5901L → P.3 Publications
    Corresponds to variant rs10823607 [ dbSNP | Ensembl ].
    VAR_047838
    Natural varianti937 – 9371L → M.
    Corresponds to variant rs12774070 [ dbSNP | Ensembl ].
    VAR_047839
    Natural varianti1017 – 10171S → N.
    Corresponds to variant rs10999516 [ dbSNP | Ensembl ].
    VAR_047840
    Natural varianti1049 – 10491E → G.
    Corresponds to variant rs4747096 [ dbSNP | Ensembl ].
    VAR_047841

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6767Missing in isoform B and isoform C. 1 PublicationVSP_006958Add
    BLAST
    Alternative sequencei368 – 3681G → GMQG in isoform C and isoform D. 1 PublicationVSP_005501

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF358666 mRNA. Translation: AAL40229.1.
    AJ345098 mRNA. Translation: CAC87943.1.
    AL358817, AL355344 Genomic DNA. Translation: CAI13857.1.
    AL358817, AL355344 Genomic DNA. Translation: CAI13858.1.
    AL355344, AL358817 Genomic DNA. Translation: CAI41277.1.
    AL355344, AL358817 Genomic DNA. Translation: CAI41278.1.
    CH471083 Genomic DNA. Translation: EAW54409.1.
    CH471083 Genomic DNA. Translation: EAW54410.1.
    AF366351 mRNA. Translation: AAL79814.1.
    CCDSiCCDS7306.1. [Q8WXS8-1]
    CCDS7307.1. [Q8WXS8-4]
    RefSeqiNP_542453.2. NM_080722.3. [Q8WXS8-1]
    NP_631894.2. NM_139155.2. [Q8WXS8-4]
    UniGeneiHs.352156.

    Genome annotation databases

    EnsembliENST00000373207; ENSP00000362303; ENSG00000138316. [Q8WXS8-1]
    ENST00000373208; ENSP00000362304; ENSG00000138316. [Q8WXS8-4]
    GeneIDi140766.
    KEGGihsa:140766.
    UCSCiuc001jrg.3. human. [Q8WXS8-4]
    uc001jrh.3. human. [Q8WXS8-1]

    Polymorphism databases

    DMDMi317373325.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF358666 mRNA. Translation: AAL40229.1 .
    AJ345098 mRNA. Translation: CAC87943.1 .
    AL358817 , AL355344 Genomic DNA. Translation: CAI13857.1 .
    AL358817 , AL355344 Genomic DNA. Translation: CAI13858.1 .
    AL355344 , AL358817 Genomic DNA. Translation: CAI41277.1 .
    AL355344 , AL358817 Genomic DNA. Translation: CAI41278.1 .
    CH471083 Genomic DNA. Translation: EAW54409.1 .
    CH471083 Genomic DNA. Translation: EAW54410.1 .
    AF366351 mRNA. Translation: AAL79814.1 .
    CCDSi CCDS7306.1. [Q8WXS8-1 ]
    CCDS7307.1. [Q8WXS8-4 ]
    RefSeqi NP_542453.2. NM_080722.3. [Q8WXS8-1 ]
    NP_631894.2. NM_139155.2. [Q8WXS8-4 ]
    UniGenei Hs.352156.

    3D structure databases

    ProteinModelPortali Q8WXS8.
    SMRi Q8WXS8. Positions 261-720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000362304.

    Protein family/group databases

    MEROPSi M12.024.

    PTM databases

    PhosphoSitei Q8WXS8.

    Polymorphism databases

    DMDMi 317373325.

    Proteomic databases

    PaxDbi Q8WXS8.
    PRIDEi Q8WXS8.

    Protocols and materials databases

    DNASUi 140766.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373207 ; ENSP00000362303 ; ENSG00000138316 . [Q8WXS8-1 ]
    ENST00000373208 ; ENSP00000362304 ; ENSG00000138316 . [Q8WXS8-4 ]
    GeneIDi 140766.
    KEGGi hsa:140766.
    UCSCi uc001jrg.3. human. [Q8WXS8-4 ]
    uc001jrh.3. human. [Q8WXS8-1 ]

    Organism-specific databases

    CTDi 140766.
    GeneCardsi GC10P072432.
    H-InvDB HIX0025921.
    HGNCi HGNC:14899. ADAMTS14.
    HPAi HPA034605.
    MIMi 607506. gene.
    neXtProti NX_Q8WXS8.
    PharmGKBi PA24540.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307411.
    HOGENOMi HOG000034222.
    HOVERGENi HBG004314.
    KOi K08628.
    OMAi LPSYDCL.
    OrthoDBi EOG76HQ0N.
    PhylomeDBi Q8WXS8.
    TreeFami TF313537.

    Enzyme and pathway databases

    Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_200626. O-glycosylation of TSR domain-containing proteins.

    Miscellaneous databases

    GenomeRNAii 140766.
    NextBioi 84365.
    PROi Q8WXS8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WXS8.
    CleanExi HS_ADAMTS14.
    Genevestigatori Q8WXS8.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    InterProi IPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR010909. PLAC.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 4 hits.
    [Graphical view ]
    PRINTSi PR01857. ADAMTSFAMILY.
    SMARTi SM00209. TSP1. 4 hits.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 4 hits.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS50900. PLAC. 1 hit.
    PS50092. TSP1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family."
      Bolz H., Ramirez A., von Brederlow B., Kubisch C.
      Biochim. Biophys. Acta 1522:221-225(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANT PRO-590.
    2. "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains."
      Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C.
      Gene 283:49-62(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANT PRO-590.
      Tissue: Fetal lung.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3."
      Colige A., Vandenberghe I., Thiry M., Lambert C.A., Van Beeumen J., Li S.-W., Prockop D.J., Lapiere C.M., Nusgens B.V.
      J. Biol. Chem. 277:5756-5766(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-1223 (ISOFORMS B; C AND D), ALTERNATIVE PROMOTER USAGE, VARIANT PRO-590.

    Entry informationi

    Entry nameiATS14_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXS8
    Secondary accession number(s): Q5T4G0
    , Q5T4G1, Q8TE55, Q8TEY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3