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Q8WXS5

- CCG8_HUMAN

UniProt

Q8WXS5 - CCG8_HUMAN

Protein

Voltage-dependent calcium channel gamma-8 subunit

Gene

CACNG8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.2 Publications

    GO - Molecular functioni

    1. voltage-gated calcium channel activity Source: UniProtKB

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB
    2. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
    3. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_18307. Trafficking of AMPA receptors.

    Protein family/group databases

    TCDBi8.A.16.2.6. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-8 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-8 subunit
    Transmembrane AMPAR regulatory protein gamma-8
    Short name:
    TARP gamma-8
    Gene namesi
    Name:CACNG8
    Synonyms:CACNG6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13628. CACNG8.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
    2. cell junction Source: UniProtKB-KW
    3. endocytic vesicle membrane Source: Reactome
    4. plasma membrane Source: Reactome
    5. postsynaptic density Source: UniProtKB
    6. postsynaptic membrane Source: UniProtKB-KW
    7. voltage-gated calcium channel complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26022.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Voltage-dependent calcium channel gamma-8 subunitPRO_0000164690Add
    BLAST

    Proteomic databases

    PaxDbiQ8WXS5.
    PRIDEiQ8WXS5.

    PTM databases

    PhosphoSiteiQ8WXS5.

    Expressioni

    Gene expression databases

    BgeeiQ8WXS5.
    CleanExiHS_CACNG6.
    HS_CACNG8.
    GenevestigatoriQ8WXS5.

    Organism-specific databases

    HPAiHPA041351.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000270458.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXS5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi247 – 380134Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43469.
    HOGENOMiHOG000233440.
    HOVERGENiHBG003682.
    InParanoidiQ8WXS5.
    KOiK04873.
    OrthoDBiEOG7TQV1Q.
    PhylomeDBiQ8WXS5.
    TreeFamiTF327980.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR008372. VDCC_g8su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01796. VDCCGAMMA8.

    Sequencei

    Sequence statusi: Complete.

    Q8WXS5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESLKRWNEE RGLWCEKGVQ VLLTTVGAFA AFGLMTIAIS TDYWLYTRAL    50
    ICNTTNLTAG GDDGTPHRGG GGASEKKDPG GLTHSGLWRI CCLEGLKRGV 100
    CVKINHFPED TDYDHDSAEY LLRVVRASSI FPILSAILLL LGGVCVAASR 150
    VYKSKRNIIL GAGILFVAAG LSNIIGVIVY ISANAGEPGP KRDEEKKNHY 200
    SYGWSFYFGG LSFILAEVIG VLAVNIYIER SREAHCQSRS DLLKAGGGAG 250
    GSGGSGPSAI LRLPSYRFRY RRRSRSSSRS SEPSPSRDAS PGGPGGPGFA 300
    STDISMYTLS RDPSKGSVAA GLAGAGGGGG GAVGAFGGAA GGAGGGGGGG 350
    GGAGAERDRG GASGFLTLHN AFPKEAGGGV TVTVTGPPAP PAPAPPAPSA 400
    PAPGTLAKEA AASNTNTLNR KTTPV 425
    Length:425
    Mass (Da):43,313
    Last modified:November 30, 2010 - v3
    Checksum:iE8C33CC5CF6184A1
    GO

    Sequence cautioni

    The sequence AAK15019.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
    The sequence AAL50049.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161E → K in AAK15019. 1 PublicationCurated
    Sequence conflicti362 – 3621A → S in AAL50049. (PubMed:11738816)Curated
    Sequence conflicti386 – 3861G → R in AAL50049. (PubMed:11738816)Curated
    Sequence conflicti394 – 3941A → T in AAL50049. (PubMed:11738816)Curated
    Sequence conflicti409 – 4091E → G in AAL50049. (PubMed:11738816)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361354 mRNA. Translation: AAL50049.1. Frameshift.
    AC008440 Genomic DNA. No translation available.
    AF234892 mRNA. Translation: AAK15019.1. Sequence problems.
    AF288388 mRNA. Translation: AAK20031.1.
    CCDSiCCDS33104.1.
    RefSeqiNP_114101.4. NM_031895.5.
    UniGeneiHs.631595.

    Genome annotation databases

    EnsembliENST00000270458; ENSP00000270458; ENSG00000142408.
    GeneIDi59283.
    KEGGihsa:59283.
    UCSCiuc002qcs.2. human.

    Polymorphism databases

    DMDMi313104245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361354 mRNA. Translation: AAL50049.1 . Frameshift.
    AC008440 Genomic DNA. No translation available.
    AF234892 mRNA. Translation: AAK15019.1 . Sequence problems.
    AF288388 mRNA. Translation: AAK20031.1 .
    CCDSi CCDS33104.1.
    RefSeqi NP_114101.4. NM_031895.5.
    UniGenei Hs.631595.

    3D structure databases

    ProteinModelPortali Q8WXS5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000270458.

    Chemistry

    ChEMBLi CHEMBL2363032.

    Protein family/group databases

    TCDBi 8.A.16.2.6. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    PTM databases

    PhosphoSitei Q8WXS5.

    Polymorphism databases

    DMDMi 313104245.

    Proteomic databases

    PaxDbi Q8WXS5.
    PRIDEi Q8WXS5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270458 ; ENSP00000270458 ; ENSG00000142408 .
    GeneIDi 59283.
    KEGGi hsa:59283.
    UCSCi uc002qcs.2. human.

    Organism-specific databases

    CTDi 59283.
    GeneCardsi GC19P054466.
    H-InvDB HIX0202898.
    HGNCi HGNC:13628. CACNG8.
    HPAi HPA041351.
    MIMi 606900. gene.
    neXtProti NX_Q8WXS5.
    PharmGKBi PA26022.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43469.
    HOGENOMi HOG000233440.
    HOVERGENi HBG003682.
    InParanoidi Q8WXS5.
    KOi K04873.
    OrthoDBi EOG7TQV1Q.
    PhylomeDBi Q8WXS5.
    TreeFami TF327980.

    Enzyme and pathway databases

    Reactomei REACT_18307. Trafficking of AMPA receptors.

    Miscellaneous databases

    ChiTaRSi CACNG8. human.
    GenomeRNAii 59283.
    NextBioi 65170.
    PROi Q8WXS5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WXS5.
    CleanExi HS_CACNG6.
    HS_CACNG8.
    Genevestigatori Q8WXS5.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR008372. VDCC_g8su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01796. VDCCGAMMA8.
    ProtoNeti Search...

    Publicationsi

    1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
      Chu P.-J., Robertson H.M., Best P.M.
      Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Proposed Homo sapiens voltage-gated calcium channel gamma-6 subunit."
      Black J.L. III, Kryzer T.J., Lennon V.A.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-204.
      Tissue: Cerebellum.
    4. "A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family."
      Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L.
      Genomics 71:339-350(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-425.
    5. "Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
      Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.
      Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating."
      Shi Y., Suh Y.H., Milstein A.D., Isozaki K., Schmid S.M., Roche K.W., Nicoll R.A.
      Proc. Natl. Acad. Sci. U.S.A. 107:16315-16319(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCCG8_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXS5
    Secondary accession number(s): Q9BXT0, Q9BY23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3