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Protein

Voltage-dependent calcium channel gamma-8 subunit

Gene

CACNG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.2 Publications

GO - Molecular functioni

  1. voltage-gated calcium channel activity Source: UniProtKB

GO - Biological processi

  1. calcium ion transport Source: UniProtKB
  2. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_18307. Trafficking of AMPA receptors.

Protein family/group databases

TCDBi8.A.16.2.6. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-8 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-8 subunit
Transmembrane AMPAR regulatory protein gamma-8
Short name:
TARP gamma-8
Gene namesi
Name:CACNG8
Synonyms:CACNG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13628. CACNG8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence AnalysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. endocytic vesicle membrane Source: Reactome
  4. plasma membrane Source: Reactome
  5. postsynaptic density Source: UniProtKB
  6. postsynaptic membrane Source: UniProtKB-KW
  7. voltage-gated calcium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Voltage-dependent calcium channel gamma-8 subunitPRO_0000164690Add
BLAST

Proteomic databases

PaxDbiQ8WXS5.
PRIDEiQ8WXS5.

PTM databases

PhosphoSiteiQ8WXS5.

Expressioni

Gene expression databases

BgeeiQ8WXS5.
CleanExiHS_CACNG6.
HS_CACNG8.
GenevestigatoriQ8WXS5.

Organism-specific databases

HPAiHPA041351.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000270458.

Structurei

3D structure databases

ProteinModelPortaliQ8WXS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi247 – 380134Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43469.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ8WXS5.
KOiK04873.
OrthoDBiEOG7TQV1Q.
PhylomeDBiQ8WXS5.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008372. VDCC_g8su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01796. VDCCGAMMA8.

Sequencei

Sequence statusi: Complete.

Q8WXS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLKRWNEE RGLWCEKGVQ VLLTTVGAFA AFGLMTIAIS TDYWLYTRAL
60 70 80 90 100
ICNTTNLTAG GDDGTPHRGG GGASEKKDPG GLTHSGLWRI CCLEGLKRGV
110 120 130 140 150
CVKINHFPED TDYDHDSAEY LLRVVRASSI FPILSAILLL LGGVCVAASR
160 170 180 190 200
VYKSKRNIIL GAGILFVAAG LSNIIGVIVY ISANAGEPGP KRDEEKKNHY
210 220 230 240 250
SYGWSFYFGG LSFILAEVIG VLAVNIYIER SREAHCQSRS DLLKAGGGAG
260 270 280 290 300
GSGGSGPSAI LRLPSYRFRY RRRSRSSSRS SEPSPSRDAS PGGPGGPGFA
310 320 330 340 350
STDISMYTLS RDPSKGSVAA GLAGAGGGGG GAVGAFGGAA GGAGGGGGGG
360 370 380 390 400
GGAGAERDRG GASGFLTLHN AFPKEAGGGV TVTVTGPPAP PAPAPPAPSA
410 420
PAPGTLAKEA AASNTNTLNR KTTPV
Length:425
Mass (Da):43,313
Last modified:November 29, 2010 - v3
Checksum:iE8C33CC5CF6184A1
GO

Sequence cautioni

The sequence AAK15019.1 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAL50049.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161E → K in AAK15019 (Ref. 3) Curated
Sequence conflicti362 – 3621A → S in AAL50049 (PubMed:11738816).Curated
Sequence conflicti386 – 3861G → R in AAL50049 (PubMed:11738816).Curated
Sequence conflicti394 – 3941A → T in AAL50049 (PubMed:11738816).Curated
Sequence conflicti409 – 4091E → G in AAL50049 (PubMed:11738816).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361354 mRNA. Translation: AAL50049.1. Frameshift.
AC008440 Genomic DNA. No translation available.
AF234892 mRNA. Translation: AAK15019.1. Sequence problems.
AF288388 mRNA. Translation: AAK20031.1.
CCDSiCCDS33104.1.
RefSeqiNP_114101.4. NM_031895.5.
UniGeneiHs.631595.

Genome annotation databases

EnsembliENST00000270458; ENSP00000270458; ENSG00000142408.
GeneIDi59283.
KEGGihsa:59283.
UCSCiuc002qcs.2. human.

Polymorphism databases

DMDMi313104245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361354 mRNA. Translation: AAL50049.1. Frameshift.
AC008440 Genomic DNA. No translation available.
AF234892 mRNA. Translation: AAK15019.1. Sequence problems.
AF288388 mRNA. Translation: AAK20031.1.
CCDSiCCDS33104.1.
RefSeqiNP_114101.4. NM_031895.5.
UniGeneiHs.631595.

3D structure databases

ProteinModelPortaliQ8WXS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000270458.

Chemistry

ChEMBLiCHEMBL2363032.

Protein family/group databases

TCDBi8.A.16.2.6. the ca(+) channel auxiliary subunit 1-8 (cca) family.

PTM databases

PhosphoSiteiQ8WXS5.

Polymorphism databases

DMDMi313104245.

Proteomic databases

PaxDbiQ8WXS5.
PRIDEiQ8WXS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270458; ENSP00000270458; ENSG00000142408.
GeneIDi59283.
KEGGihsa:59283.
UCSCiuc002qcs.2. human.

Organism-specific databases

CTDi59283.
GeneCardsiGC19P054466.
H-InvDBHIX0202898.
HGNCiHGNC:13628. CACNG8.
HPAiHPA041351.
MIMi606900. gene.
neXtProtiNX_Q8WXS5.
PharmGKBiPA26022.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43469.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ8WXS5.
KOiK04873.
OrthoDBiEOG7TQV1Q.
PhylomeDBiQ8WXS5.
TreeFamiTF327980.

Enzyme and pathway databases

ReactomeiREACT_18307. Trafficking of AMPA receptors.

Miscellaneous databases

ChiTaRSiCACNG8. human.
GenomeRNAii59283.
NextBioi65170.
PROiQ8WXS5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WXS5.
CleanExiHS_CACNG6.
HS_CACNG8.
GenevestigatoriQ8WXS5.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008372. VDCC_g8su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01796. VDCCGAMMA8.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Proposed Homo sapiens voltage-gated calcium channel gamma-6 subunit."
    Black J.L. III, Kryzer T.J., Lennon V.A.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-204.
    Tissue: Cerebellum.
  4. "A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family."
    Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L.
    Genomics 71:339-350(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-425.
  5. "Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
    Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.
    Neuron 68:1082-1096(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating."
    Shi Y., Suh Y.H., Milstein A.D., Isozaki K., Schmid S.M., Roche K.W., Nicoll R.A.
    Proc. Natl. Acad. Sci. U.S.A. 107:16315-16319(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCCG8_HUMAN
AccessioniPrimary (citable) accession number: Q8WXS5
Secondary accession number(s): Q9BXT0, Q9BY23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2002
Last sequence update: November 29, 2010
Last modified: January 6, 2015
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.