Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8WXS5 (CCG8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent calcium channel gamma-8 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-8 subunit
Transmembrane AMPAR regulatory protein gamma-8
Short name=TARP gamma-8
Gene names
Name:CACNG8
Synonyms:CACNG6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Ref.5 Ref.6

Subunit structure

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity.

Sequence similarities

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Sequence caution

The sequence AAK15019.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

The sequence AAL50049.1 differs from that shown. Reason: Frameshift at several positions.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Voltage-dependent calcium channel gamma-8 subunit
PRO_0000164690

Regions

Transmembrane19 – 3921Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane158 – 17821Helical; Potential
Transmembrane208 – 22821Helical; Potential
Transmembrane318 – 33821Helical; Potential
Compositional bias247 – 380134Gly-rich

Experimental info

Sequence conflict161E → K in AAK15019. Ref.3
Sequence conflict3621A → S in AAL50049. Ref.1
Sequence conflict3861G → R in AAL50049. Ref.1
Sequence conflict3941A → T in AAL50049. Ref.1
Sequence conflict4091E → G in AAL50049. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8WXS5 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: E8C33CC5CF6184A1

FASTA42543,313
        10         20         30         40         50         60 
MESLKRWNEE RGLWCEKGVQ VLLTTVGAFA AFGLMTIAIS TDYWLYTRAL ICNTTNLTAG 

        70         80         90        100        110        120 
GDDGTPHRGG GGASEKKDPG GLTHSGLWRI CCLEGLKRGV CVKINHFPED TDYDHDSAEY 

       130        140        150        160        170        180 
LLRVVRASSI FPILSAILLL LGGVCVAASR VYKSKRNIIL GAGILFVAAG LSNIIGVIVY 

       190        200        210        220        230        240 
ISANAGEPGP KRDEEKKNHY SYGWSFYFGG LSFILAEVIG VLAVNIYIER SREAHCQSRS 

       250        260        270        280        290        300 
DLLKAGGGAG GSGGSGPSAI LRLPSYRFRY RRRSRSSSRS SEPSPSRDAS PGGPGGPGFA 

       310        320        330        340        350        360 
STDISMYTLS RDPSKGSVAA GLAGAGGGGG GAVGAFGGAA GGAGGGGGGG GGAGAERDRG 

       370        380        390        400        410        420 
GASGFLTLHN AFPKEAGGGV TVTVTGPPAP PAPAPPAPSA PAPGTLAKEA AASNTNTLNR 


KTTPV 

« Hide

References

« Hide 'large scale' references
[1]"Calcium channel gamma subunits provide insights into the evolution of this gene family."
Chu P.-J., Robertson H.M., Best P.M.
Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Proposed Homo sapiens voltage-gated calcium channel gamma-6 subunit."
Black J.L. III, Kryzer T.J., Lennon V.A.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-204.
Tissue: Cerebellum.
[4]"A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family."
Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L.
Genomics 71:339-350(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-425.
[5]"Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.
Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating."
Shi Y., Suh Y.H., Milstein A.D., Isozaki K., Schmid S.M., Roche K.W., Nicoll R.A.
Proc. Natl. Acad. Sci. U.S.A. 107:16315-16319(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF361354 mRNA. Translation: AAL50049.1. Frameshift.
AC008440 Genomic DNA. No translation available.
AF234892 mRNA. Translation: AAK15019.1. Sequence problems.
AF288388 mRNA. Translation: AAK20031.1.
RefSeqNP_114101.4. NM_031895.5.
UniGeneHs.631595.

3D structure databases

ProteinModelPortalQ8WXS5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000270458.

Chemistry

ChEMBLCHEMBL2363032.

Protein family/group databases

TCDB8.A.16.2.6. the ca(+) channel auxiliary subunit 1-8 (cca) family.

PTM databases

PhosphoSiteQ8WXS5.

Polymorphism databases

DMDM313104245.

Proteomic databases

PaxDbQ8WXS5.
PRIDEQ8WXS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000270458; ENSP00000270458; ENSG00000142408.
GeneID59283.
KEGGhsa:59283.
UCSCuc002qcs.2. human.

Organism-specific databases

CTD59283.
GeneCardsGC19P054466.
H-InvDBHIX0202898.
HGNCHGNC:13628. CACNG8.
HPAHPA041351.
MIM606900. gene.
neXtProtNX_Q8WXS5.
PharmGKBPA26022.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43469.
HOGENOMHOG000233440.
HOVERGENHBG003682.
InParanoidQ8WXS5.
KOK04873.
OrthoDBEOG7TQV1Q.
PhylomeDBQ8WXS5.
TreeFamTF327980.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeQ8WXS5.
CleanExHS_CACNG6.
HS_CACNG8.
GenevestigatorQ8WXS5.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
IPR008372. VDCC_g8su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01792. VDCCGAMMA.
PR01796. VDCCGAMMA8.
ProtoNetSearch...

Other

ChiTaRSCACNG8. human.
GenomeRNAi59283.
NextBio65170.
PROQ8WXS5.
SOURCESearch...

Entry information

Entry nameCCG8_HUMAN
AccessionPrimary (citable) accession number: Q8WXS5
Secondary accession number(s): Q9BXT0, Q9BY23
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM