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Protein

Voltage-dependent calcium channel gamma-8 subunit

Gene

CACNG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.2 Publications

GO - Molecular functioni

GO - Biological processi

  • calcium ion transmembrane transport Source: GO_Central
  • calcium ion transport Source: UniProtKB
  • regulation of AMPA receptor activity Source: UniProtKB
  • transmission of nerve impulse Source: GO_Central

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-399719 Trafficking of AMPA receptors
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5576893 Phase 2 - plateau phase
R-HSA-5682910 LGI-ADAM interactions

Protein family/group databases

TCDBi8.A.16.2.6 the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-8 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-8 subunit
Transmembrane AMPAR regulatory protein gamma-8
Short name:
TARP gamma-8
Gene namesi
Name:CACNG8
Synonyms:CACNG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142408.2
HGNCiHGNC:13628 CACNG8
MIMi606900 gene
neXtProtiNX_Q8WXS5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi59283
OpenTargetsiENSG00000142408
PharmGKBiPA26022

Chemistry databases

ChEMBLiCHEMBL2363032

Polymorphism and mutation databases

BioMutaiCACNG8
DMDMi313104245

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646901 – 425Voltage-dependent calcium channel gamma-8 subunitAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei252PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8WXS5
PeptideAtlasiQ8WXS5
PRIDEiQ8WXS5

PTM databases

iPTMnetiQ8WXS5
PhosphoSitePlusiQ8WXS5

Expressioni

Gene expression databases

BgeeiENSG00000142408
CleanExiHS_CACNG6
HS_CACNG8
ExpressionAtlasiQ8WXS5 baseline and differential
GenevisibleiQ8WXS5 HS

Organism-specific databases

HPAiHPA041351

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000270458

Structurei

3D structure databases

ProteinModelPortaliQ8WXS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi247 – 380Gly-richAdd BLAST134

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVW Eukaryota
ENOG4110B1C LUCA
GeneTreeiENSGT00550000074547
HOGENOMiHOG000233440
HOVERGENiHBG003682
InParanoidiQ8WXS5
KOiK04873
OrthoDBiEOG091G0D2Z
PhylomeDBiQ8WXS5
TreeFamiTF327980

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR008372 VDCC_g8su
IPR008368 VDCC_gsu
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01792 VDCCGAMMA
PR01796 VDCCGAMMA8

Sequencei

Sequence statusi: Complete.

Q8WXS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLKRWNEE RGLWCEKGVQ VLLTTVGAFA AFGLMTIAIS TDYWLYTRAL
60 70 80 90 100
ICNTTNLTAG GDDGTPHRGG GGASEKKDPG GLTHSGLWRI CCLEGLKRGV
110 120 130 140 150
CVKINHFPED TDYDHDSAEY LLRVVRASSI FPILSAILLL LGGVCVAASR
160 170 180 190 200
VYKSKRNIIL GAGILFVAAG LSNIIGVIVY ISANAGEPGP KRDEEKKNHY
210 220 230 240 250
SYGWSFYFGG LSFILAEVIG VLAVNIYIER SREAHCQSRS DLLKAGGGAG
260 270 280 290 300
GSGGSGPSAI LRLPSYRFRY RRRSRSSSRS SEPSPSRDAS PGGPGGPGFA
310 320 330 340 350
STDISMYTLS RDPSKGSVAA GLAGAGGGGG GAVGAFGGAA GGAGGGGGGG
360 370 380 390 400
GGAGAERDRG GASGFLTLHN AFPKEAGGGV TVTVTGPPAP PAPAPPAPSA
410 420
PAPGTLAKEA AASNTNTLNR KTTPV
Length:425
Mass (Da):43,313
Last modified:November 30, 2010 - v3
Checksum:iE8C33CC5CF6184A1
GO

Sequence cautioni

The sequence AAK15019 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAL50049 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16E → K in AAK15019 (Ref. 3) Curated1
Sequence conflicti362A → S in AAL50049 (PubMed:11738816).Curated1
Sequence conflicti386G → R in AAL50049 (PubMed:11738816).Curated1
Sequence conflicti394A → T in AAL50049 (PubMed:11738816).Curated1
Sequence conflicti409E → G in AAL50049 (PubMed:11738816).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361354 mRNA Translation: AAL50049.1 Frameshift.
AC008440 Genomic DNA No translation available.
AF234892 mRNA Translation: AAK15019.1 Sequence problems.
AF288388 mRNA Translation: AAK20031.1
CCDSiCCDS33104.1
RefSeqiNP_114101.4, NM_031895.5
UniGeneiHs.631595

Genome annotation databases

EnsembliENST00000638874; ENSP00000492637; ENSG00000142408
GeneIDi59283
KEGGihsa:59283
UCSCiuc061clu.1 human

Similar proteinsi

Entry informationi

Entry nameiCCG8_HUMAN
AccessioniPrimary (citable) accession number: Q8WXS5
Secondary accession number(s): Q9BXT0, Q9BY23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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