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Protein

Voltage-dependent calcium channel gamma-like subunit

Gene

TMEM37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-like subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-like subunit
Transmembrane protein 37
Gene namesi
Name:TMEM37Imported
Synonyms:PR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18216. TMEM37.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134897608.

Polymorphism and mutation databases

BioMutaiTMEM37.
DMDMi296434430.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Voltage-dependent calcium channel gamma-like subunitPRO_0000225601Add
BLAST

Proteomic databases

PaxDbiQ8WXS4.
PRIDEiQ8WXS4.

Expressioni

Gene expression databases

BgeeiQ8WXS4.
CleanExiHS_TMEM37.
ExpressionAtlasiQ8WXS4. baseline and differential.
GenevisibleiQ8WXS4. HS.

Organism-specific databases

HPAiHPA053794.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.By similarity

Protein-protein interaction databases

BioGridi126681. 6 interactions.
IntActiQ8WXS4. 6 interactions.
STRINGi9606.ENSP00000303148.

Structurei

3D structure databases

ProteinModelPortaliQ8WXS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8N. Eukaryota.
ENOG4111WUN. LUCA.
GeneTreeiENSGT00390000006225.
HOGENOMiHOG000111447.
HOVERGENiHBG028482.
InParanoidiQ8WXS4.
PhylomeDBiQ8WXS4.
TreeFamiTF333259.

Family and domain databases

InterProiIPR029372. Tmem37.
[Graphical view]
PANTHERiPTHR31767:SF0. PTHR31767:SF0. 1 hit.
PfamiPF15108. TMEM37. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVGVQAQR PLGQRQPRRS FFESFIRTLI ITCVALAVVL SSVSICDGHW
60 70 80 90 100
LLAEDRLFGL WHFCTTTNQT ICFRDLGQAH VPGLAVGMGL VRSVGALAVV
110 120 130 140 150
AAIFGLEFLM VSQLCEDKHS QCKWVMGSIL LLVSFVLSSG GLLGFVILLR
160 170 180 190
NQVTLIGFTL MFWCEFTASF LLFLNAISGL HINSITHPWE
Length:190
Mass (Da):20,932
Last modified:May 18, 2010 - v2
Checksum:iCDDC58485DF57FD7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71Q → H in AAL50051 (PubMed:11738816).Curated
Sequence conflicti70 – 701T → SVP in AAL50051 (PubMed:11738816).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361356 mRNA. Translation: AAL50051.1.
AC013275 Genomic DNA. No translation available.
CCDSiCCDS33281.1.
RefSeqiNP_899063.2. NM_183240.2.
UniGeneiHs.26216.

Genome annotation databases

EnsembliENST00000306406; ENSP00000303148; ENSG00000171227.
GeneIDi140738.
KEGGihsa:140738.
UCSCiuc002tly.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361356 mRNA. Translation: AAL50051.1.
AC013275 Genomic DNA. No translation available.
CCDSiCCDS33281.1.
RefSeqiNP_899063.2. NM_183240.2.
UniGeneiHs.26216.

3D structure databases

ProteinModelPortaliQ8WXS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126681. 6 interactions.
IntActiQ8WXS4. 6 interactions.
STRINGi9606.ENSP00000303148.

Polymorphism and mutation databases

BioMutaiTMEM37.
DMDMi296434430.

Proteomic databases

PaxDbiQ8WXS4.
PRIDEiQ8WXS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306406; ENSP00000303148; ENSG00000171227.
GeneIDi140738.
KEGGihsa:140738.
UCSCiuc002tly.4. human.

Organism-specific databases

CTDi140738.
GeneCardsiTMEM37.
H-InvDBHIX0002409.
HGNCiHGNC:18216. TMEM37.
HPAiHPA053794.
neXtProtiNX_Q8WXS4.
PharmGKBiPA134897608.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8N. Eukaryota.
ENOG4111WUN. LUCA.
GeneTreeiENSGT00390000006225.
HOGENOMiHOG000111447.
HOVERGENiHBG028482.
InParanoidiQ8WXS4.
PhylomeDBiQ8WXS4.
TreeFamiTF333259.

Miscellaneous databases

ChiTaRSiTMEM37. human.
GenomeRNAii140738.
NextBioi84329.
PROiQ8WXS4.

Gene expression databases

BgeeiQ8WXS4.
CleanExiHS_TMEM37.
ExpressionAtlasiQ8WXS4. baseline and differential.
GenevisibleiQ8WXS4. HS.

Family and domain databases

InterProiIPR029372. Tmem37.
[Graphical view]
PANTHERiPTHR31767:SF0. PTHR31767:SF0. 1 hit.
PfamiPF15108. TMEM37. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCCGL_HUMAN
AccessioniPrimary (citable) accession number: Q8WXS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.