ID   MYO3B_HUMAN             Reviewed;        1341 AA.
AC   Q8WXR4; B8ZZR2; Q53QE1; Q53T08; Q8IX64; Q8IX65; Q8IX66; Q8IX67; Q8IX68;
AC   Q96N94;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 4.
DT   24-JAN-2024, entry version 180.
DE   RecName: Full=Myosin-IIIb;
DE            EC=2.7.11.1;
GN   Name=MYO3B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), ALTERNATIVE
RP   SPLICING, AND VARIANT LYS-1082.
RX   PubMed=11991710; DOI=10.1006/geno.2002.6749;
RA   Dose A.C., Burnside B.;
RT   "A class III myosin expressed in the retina is a potential candidate for
RT   Bardet-Biedl syndrome.";
RL   Genomics 79:621-624(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1104 (ISOFORM 7), AND VARIANTS
RP   GLU-309; ILE-770; GLY-773 AND LYS-1082.
RC   TISSUE=Kidney;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   VARIANTS [LARGE SCALE ANALYSIS] SER-21; HIS-185; SER-267; VAL-275; GLU-309;
RP   LEU-316; GLN-352; SER-388; THR-406; PRO-638; ILE-770; GLY-773; GLN-918;
RP   CYS-969; CYS-990; VAL-1092; ILE-1137 AND CYS-1165.
RX   PubMed=17344846; DOI=10.1038/nature05610;
RA   Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G.,
RA   Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S.,
RA   Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.,
RA   Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K.,
RA   Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D.,
RA   Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R.,
RA   Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A.,
RA   Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F.,
RA   Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F.,
RA   Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G.,
RA   Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R.,
RA   Futreal P.A., Stratton M.R.;
RT   "Patterns of somatic mutation in human cancer genomes.";
RL   Nature 446:153-158(2007).
CC   -!- FUNCTION: Probable actin-based motor with a protein kinase activity.
CC       Required for normal cochlear hair bundle development and hearing. Plays
CC       an important role in the early steps of cochlear hair bundle
CC       morphogenesis. Influences the number and lengths of stereocilia to be
CC       produced and limits the growth of microvilli within the forming
CC       auditory hair bundles thereby contributing to the architecture of the
CC       hair bundle, including its staircase pattern. Involved in the
CC       elongation of actin in stereocilia tips by transporting the actin
CC       regulatory factor ESPN to the plus ends of actin filaments.
CC       {ECO:0000250|UniProtKB:Q1EG27}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1;
CC   -!- SUBUNIT: Interacts (via C-terminus) with ESPN. Interacts (via C-
CC       terminus) with ESPNL. {ECO:0000250|UniProtKB:Q1EG27}.
CC   -!- INTERACTION:
CC       Q8WXR4; P08238: HSP90AB1; NbExp=2; IntAct=EBI-350672, EBI-352572;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection,
CC       stereocilium {ECO:0000250|UniProtKB:Q1EG27}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=7;
CC       Name=1; Synonyms=MYO3B.2;
CC         IsoId=Q8WXR4-1; Sequence=Displayed;
CC       Name=2; Synonyms=MYO3B.0;
CC         IsoId=Q8WXR4-2; Sequence=VSP_010163;
CC       Name=3; Synonyms=MYO3B.1;
CC         IsoId=Q8WXR4-3; Sequence=VSP_010162, VSP_010163;
CC       Name=4; Synonyms=MYO3B.3;
CC         IsoId=Q8WXR4-4; Sequence=VSP_010162;
CC       Name=5; Synonyms=MYO3B.4;
CC         IsoId=Q8WXR4-5; Sequence=VSP_010164;
CC       Name=6; Synonyms=MYO3B.5;
CC         IsoId=Q8WXR4-6; Sequence=VSP_010165;
CC       Name=7;
CC         IsoId=Q8WXR4-7; Sequence=VSP_023111;
CC   -!- TISSUE SPECIFICITY: Expressed in retina, kidney and testis.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the TRAFAC class
CC       myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000305}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the protein kinase
CC       superfamily. STE Ser/Thr protein kinase family. {ECO:0000305}.
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DR   EMBL; AF369908; AAL57233.1; -; mRNA.
DR   EMBL; AF391554; AAO13799.1; -; mRNA.
DR   EMBL; AF391555; AAO13800.1; -; mRNA.
DR   EMBL; AF391556; AAO13801.1; -; mRNA.
DR   EMBL; AF391557; AAO13802.1; -; mRNA.
DR   EMBL; AF391558; AAO13803.1; -; mRNA.
DR   EMBL; AC007277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC012594; AAY24324.1; -; Genomic_DNA.
DR   EMBL; AC068280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114794; AAY24159.1; -; Genomic_DNA.
DR   EMBL; AK055778; BAB71011.1; -; mRNA.
DR   CCDS; CCDS42773.1; -. [Q8WXR4-1]
DR   CCDS; CCDS46446.1; -. [Q8WXR4-4]
DR   RefSeq; NP_001077084.2; NM_001083615.3. [Q8WXR4-4]
DR   RefSeq; NP_620482.3; NM_138995.4. [Q8WXR4-1]
DR   RefSeq; XP_006712362.1; XM_006712299.3. [Q8WXR4-7]
DR   AlphaFoldDB; Q8WXR4; -.
DR   SMR; Q8WXR4; -.
DR   BioGRID; 126621; 47.
DR   IntAct; Q8WXR4; 37.
DR   STRING; 9606.ENSP00000386213; -.
DR   BindingDB; Q8WXR4; -.
DR   ChEMBL; CHEMBL5654; -.
DR   DrugCentral; Q8WXR4; -.
DR   iPTMnet; Q8WXR4; -.
DR   PhosphoSitePlus; Q8WXR4; -.
DR   BioMuta; MYO3B; -.
DR   DMDM; 296439486; -.
DR   MassIVE; Q8WXR4; -.
DR   MaxQB; Q8WXR4; -.
DR   PaxDb; 9606-ENSP00000386213; -.
DR   PeptideAtlas; Q8WXR4; -.
DR   ProteomicsDB; 75080; -. [Q8WXR4-1]
DR   ProteomicsDB; 75081; -. [Q8WXR4-2]
DR   ProteomicsDB; 75082; -. [Q8WXR4-3]
DR   ProteomicsDB; 75083; -. [Q8WXR4-4]
DR   ProteomicsDB; 75084; -. [Q8WXR4-5]
DR   ProteomicsDB; 75085; -. [Q8WXR4-6]
DR   ProteomicsDB; 75086; -. [Q8WXR4-7]
DR   Antibodypedia; 33828; 184 antibodies from 27 providers.
DR   DNASU; 140469; -.
DR   Ensembl; ENST00000317935.10; ENSP00000314650.6; ENSG00000071909.19. [Q8WXR4-3]
DR   Ensembl; ENST00000408978.9; ENSP00000386213.4; ENSG00000071909.19. [Q8WXR4-1]
DR   Ensembl; ENST00000409044.7; ENSP00000386497.3; ENSG00000071909.19. [Q8WXR4-4]
DR   GeneID; 140469; -.
DR   KEGG; hsa:140469; -.
DR   MANE-Select; ENST00000408978.9; ENSP00000386213.4; NM_138995.5; NP_620482.3.
DR   UCSC; uc002ufy.4; human. [Q8WXR4-1]
DR   AGR; HGNC:15576; -.
DR   CTD; 140469; -.
DR   DisGeNET; 140469; -.
DR   GeneCards; MYO3B; -.
DR   HGNC; HGNC:15576; MYO3B.
DR   HPA; ENSG00000071909; Tissue enhanced (epididymis, kidney, parathyroid gland, retina).
DR   MIM; 610040; gene.
DR   neXtProt; NX_Q8WXR4; -.
DR   OpenTargets; ENSG00000071909; -.
DR   PharmGKB; PA31406; -.
DR   VEuPathDB; HostDB:ENSG00000071909; -.
DR   eggNOG; KOG0587; Eukaryota.
DR   eggNOG; KOG4229; Eukaryota.
DR   GeneTree; ENSGT00940000159309; -.
DR   InParanoid; Q8WXR4; -.
DR   OMA; QPDKNIW; -.
DR   OrthoDB; 1094820at2759; -.
DR   PhylomeDB; Q8WXR4; -.
DR   TreeFam; TF326512; -.
DR   PathwayCommons; Q8WXR4; -.
DR   Reactome; R-HSA-9662360; Sensory processing of sound by inner hair cells of the cochlea.
DR   Reactome; R-HSA-9662361; Sensory processing of sound by outer hair cells of the cochlea.
DR   SignaLink; Q8WXR4; -.
DR   BioGRID-ORCS; 140469; 6 hits in 1186 CRISPR screens.
DR   ChiTaRS; MYO3B; human.
DR   GenomeRNAi; 140469; -.
DR   Pharos; Q8WXR4; Tchem.
DR   PRO; PR:Q8WXR4; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q8WXR4; Protein.
DR   Bgee; ENSG00000071909; Expressed in buccal mucosa cell and 61 other cell types or tissues.
DR   ExpressionAtlas; Q8WXR4; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0032433; C:filopodium tip; IBA:GO_Central.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0001917; C:photoreceptor inner segment; IBA:GO_Central.
DR   GO; GO:0032426; C:stereocilium tip; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0090103; P:cochlea morphogenesis; ISS:UniProtKB.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0051491; P:positive regulation of filopodium assembly; IBA:GO_Central.
DR   GO; GO:0030832; P:regulation of actin filament length; IBA:GO_Central.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007605; P:sensory perception of sound; ISS:UniProtKB.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd01379; MYSc_Myo3; 1.
DR   CDD; cd06639; STKc_myosinIIIB_N; 1.
DR   Gene3D; 1.10.10.820; -; 1.
DR   Gene3D; 1.20.5.190; -; 1.
DR   Gene3D; 1.20.58.530; -; 1.
DR   Gene3D; 6.20.240.20; -; 1.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR   Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR036083; MYSc_Myo3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR46256; AGAP011099-PA; 1.
DR   PANTHER; PTHR46256:SF1; MYOSIN-IIIB; 1.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00015; IQ; 2.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50096; IQ; 2.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   Genevisible; Q8WXR4; HS.
PE   1: Evidence at protein level;
KW   Actin-binding; Alternative splicing; ATP-binding; Cell projection;
KW   Cytoplasm; Cytoskeleton; Hearing; Kinase; Motor protein; Myosin;
KW   Nucleotide-binding; Reference proteome; Repeat; Sensory transduction;
KW   Serine/threonine-protein kinase; Transferase; Vision.
FT   CHAIN           1..1341
FT                   /note="Myosin-IIIb"
FT                   /id="PRO_0000086415"
FT   DOMAIN          27..293
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   DOMAIN          343..1058
FT                   /note="Myosin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT   DOMAIN          1060..1089
FT                   /note="IQ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1087..1116
FT                   /note="IQ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          939..961
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT   REGION          1111..1205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1232..1266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1318..1341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1116..1137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1149..1171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1172..1201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1323..1341
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        156
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10027"
FT   BINDING         33..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         56
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   VAR_SEQ         1
FT                   /note="M -> MLQSALLSTR (in isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_023111"
FT   VAR_SEQ         1097..1123
FT                   /note="Missing (in isoform 3 and isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:11991710"
FT                   /id="VSP_010162"
FT   VAR_SEQ         1193..1341
FT                   /note="HSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKP
FT                   GSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNGTLEYQGSKRKPRKLGQIKVLDG
FT                   EDEYYKSLSPVDCIPEENNSAHPSFFSSSSKGDSFAQH -> WSFTLLLRLECNSMISA
FT                   DCNLRPLGSSDSPASASRVAGITGIHKPRVLQKGAISSQDMQTSTRFLGLICCLLGYAI
FT                   LLQISKD (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:11991710"
FT                   /id="VSP_010164"
FT   VAR_SEQ         1193..1341
FT                   /note="Missing (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:11991710"
FT                   /id="VSP_010165"
FT   VAR_SEQ         1245..1341
FT                   /note="GSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNGTLEYQGSKRKPRKLG
FT                   QIKVLDGEDEYYKSLSPVDCIPEENNSAHPSFFSSSSKGDSFAQH -> AFPHYGCNFY
FT                   GFRKWSCTEASNTSPTMSAAQNAE (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:11991710"
FT                   /id="VSP_010163"
FT   VARIANT         21
FT                   /note="P -> S (in dbSNP:rs35391761)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040886"
FT   VARIANT         185
FT                   /note="R -> H (in dbSNP:rs55911154)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040887"
FT   VARIANT         267
FT                   /note="N -> S (in dbSNP:rs34509373)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040888"
FT   VARIANT         275
FT                   /note="I -> V (in dbSNP:rs10209102)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_030605"
FT   VARIANT         309
FT                   /note="K -> E (in dbSNP:rs4668246)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:17344846"
FT                   /id="VAR_030606"
FT   VARIANT         316
FT                   /note="H -> L (in dbSNP:rs55633190)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040889"
FT   VARIANT         352
FT                   /note="E -> Q (in dbSNP:rs56179904)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040890"
FT   VARIANT         388
FT                   /note="N -> S (in dbSNP:rs34273653)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040891"
FT   VARIANT         406
FT                   /note="A -> T (in dbSNP:rs10168181)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_030607"
FT   VARIANT         638
FT                   /note="Q -> P (in dbSNP:rs55911627)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040892"
FT   VARIANT         770
FT                   /note="V -> I (in dbSNP:rs6736609)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:17344846"
FT                   /id="VAR_030608"
FT   VARIANT         773
FT                   /note="E -> G (in dbSNP:rs33962844)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040893"
FT   VARIANT         798
FT                   /note="E -> K (in dbSNP:rs11892763)"
FT                   /id="VAR_030609"
FT   VARIANT         918
FT                   /note="R -> Q (in dbSNP:rs55769829)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040894"
FT   VARIANT         969
FT                   /note="S -> C (in dbSNP:rs35857918)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040895"
FT   VARIANT         990
FT                   /note="R -> C (in dbSNP:rs34236931)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040896"
FT   VARIANT         1082
FT                   /note="R -> K (in dbSNP:rs10185178)"
FT                   /evidence="ECO:0000269|PubMed:11991710,
FT                   ECO:0000269|PubMed:14702039"
FT                   /id="VAR_030610"
FT   VARIANT         1092
FT                   /note="I -> V (in dbSNP:rs34219776)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040897"
FT   VARIANT         1137
FT                   /note="V -> I (in dbSNP:rs34546065)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040898"
FT   VARIANT         1165
FT                   /note="R -> C (in dbSNP:rs56052422)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_040899"
FT   CONFLICT        261
FT                   /note="K -> R (in Ref. 3; BAB71011)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        573
FT                   /note="T -> A (in Ref. 3; BAB71011)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        870
FT                   /note="K -> M (in Ref. 1;
FT                   AAL57233/AAO13799/AAO13800/AAO13801/AAO13802/AAO13803)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1081
FT                   /note="K -> N (in Ref. 3; BAB71011)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1341 AA;  151829 MW;  76F84C571DAA269D CRC64;
     MKHLYGLFHY NPMMLGLESL PDPTDTWEII ETIGKGTYGK VYKVTNKRDG SLAAVKILDP
     VSDMDEEIEA EYNILQFLPN HPNVVKFYGM FYKADHCVGG QLWLVLELCN GGSVTELVKG
     LLRCGQRLDE AMISYILYGA LLGLQHLHNN RIIHRDVKGN NILLTTEGGV KLVDFGVSAQ
     LTSTRLRRNT SVGTPFWMAP EVIACEQQYD SSYDARCDVW SLGITAIELG DGDPPLFDMH
     PVKTLFKIPR NPPPTLLHPE KWCEEFNHFI SQCLIKDFER RPSVTHLLDH PFIKGVHGKV
     LFLQKQLAKV LQDQKHQNPV AKTRHERMHT RRPYHVEDAE KYCLEDDLVN LEVLDEDTII
     HQLQKRYADL LIYTYVGDIL IALNPFQNLS IYSPQFSRLY HGVKRASNPP HIFASADAAY
     QCMVTLSKDQ CIVISGESGS GKTESAHLIV QHLTFLGKAN NQTLREKILQ VNSLVEAFGN
     SCTAINDNSS RFGKYLEMMF TPTGVVMGAR ISEYLLEKSR VIKQAAREKN FHIFYYIYAG
     LHHQKKLSDF RLPEEKPPRY IADETGRVMH DITSKESYRR QFEAIQHCFR IIGFTDKEVH
     SVYRILAGIL NIGNIEFAAI SSQHQTDKSE VPNAEALQNA ASVLCISPEE LQEALTSHCV
     VTRGETIIRA NTVDRAADVR DAMSKALYGR LFSWIVNRIN TLLQPDENIC SAGGGMNVGI
     LDIFGFENFQ RNSFEQLCIN IANEQIQYYF NQHVFALEQM EYQNEGIDAV PVEYEDNRPL
     LDMFLQKPLG LLALLDEESR FPQATDQTLV DKFEDNLRCK YFWRPKGVEL CFGIQHYAGK
     VLYDASGVLE KNRDTLPADV VVVLRTSENK LLQQLFSIPL TKTGNLAQTR ARITVASSSL
     PPHFSAGKAK VDTLEVIRHP EETTNMKRQT VASYFRYSLM DLLSKMVVGQ PHFVRCIKPN
     DDREALQFSR ERVLAQLRST GILETVSIRR QGYSHRILFE EFVKRYYYLA FTAHQTPLAS
     KESCVAILEK SRLDHWVLGK TKVFLKYYHV EQLNLLLREV IGRVVVLQAY TKGWLGARRY
     KRVREKREKG AIAIQSAWRG YDARRKFKKI SNRRNESAAH NQAGDTSNQS SGPHSPVAAG
     TRGSAEVQDC SEPGDHKVLR GSVHRRSHSQ AESNNGRTQT SSNSPAVTEK NGHSQAQSSP
     KGCDIFAGHA NKHSVSGTDL LSSRICHPAP DQQGLSLWGA PQKPGSENGL AQKHRTPRRR
     CQQPKMLSSP EDTMYYNQLN GTLEYQGSKR KPRKLGQIKV LDGEDEYYKS LSPVDCIPEE
     NNSAHPSFFS SSSKGDSFAQ H
//