Q8WXR4 (MYO3B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myosin-IIIb
EC=2.7.11.1

Gene names

Name:

MYO3B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1341 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable actin-based motor with a protein kinase activity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm › cytoskeleton.
Tissue specificity	Expressed in retina, kidney and testis.
Sequence similarities	In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. Contains 2 IQ domains. Contains 1 myosin head-like domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	ATP-binding Actin-binding Nucleotide-binding
Molecular function	Kinase Motor protein Myosin Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara peptidyl-threonine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of filopodium assembly Inferred from electronic annotation. Source: Compara protein autophosphorylation Inferred from electronic annotation. Source: Compara response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW filopodium tip Inferred from electronic annotation. Source: Compara myosin complex Inferred from electronic annotation. Source: UniProtKB-KW photoreceptor inner segment Inferred from electronic annotation. Source: Compara photoreceptor outer segment Inferred from electronic annotation. Source: Compara stereocilium bundle tip Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microfilament motor activity Inferred from electronic annotation. Source: Compara protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WXR4-1)

Also known as: MYO3B.2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WXR4-2)

Also known as: MYO3B.0;

The sequence of this isoform differs from the canonical sequence as follows:
     1245-1341: GSENGLAQKH...SSKGDSFAQH → AFPHYGCNFYGFRKWSCTEASNTSPTMSAAQNAE

Isoform 3 (identifier: Q8WXR4-3)

Also known as: MYO3B.1;

The sequence of this isoform differs from the canonical sequence as follows:
     1097-1123: Missing.
     1245-1341: GSENGLAQKH...SSKGDSFAQH → AFPHYGCNFYGFRKWSCTEASNTSPTMSAAQNAE

Isoform 4 (identifier: Q8WXR4-4)

Also known as: MYO3B.3;

The sequence of this isoform differs from the canonical sequence as follows:
     1097-1123: Missing.

Isoform 5 (identifier: Q8WXR4-5)

Also known as: MYO3B.4;

The sequence of this isoform differs from the canonical sequence as follows:
     1193-1341: HSQAQSSPKG...SSKGDSFAQH → WSFTLLLRLE...YAILLQISKD

Isoform 6 (identifier: Q8WXR4-6)

Also known as: MYO3B.5;

The sequence of this isoform differs from the canonical sequence as follows:
     1193-1341: Missing.

Isoform 7 (identifier: Q8WXR4-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLQSALLSTR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1341	1341	Myosin-IIIb		PRO_0000086415
Regions
	Domain	27 – 293	267	Protein kinase
	Domain	337 – 1059	723	Myosin head-like
	Domain	1060 – 1089	30	IQ 1
	Domain	1087 – 1116	30	IQ 2
	Nucleotide binding	33 – 41	9	ATP By similarity
Sites
	Active site	156	1	Proton acceptor By similarity
	Binding site	56	1	ATP By similarity
Natural variations
	Alternative sequence	1	1	M → MLQSALLSTR in isoform 7.		VSP_023111
	Alternative sequence	1097 – 1123	27	Missing in isoform 3 and isoform 4.		VSP_010162
	Alternative sequence	1193 – 1341	149	HSQAQ…SFAQH → WSFTLLLRLECNSMISADCN LRPLGSSDSPASASRVAGIT GIHKPRVLQKGAISSQDMQT STRFLGLICCLLGYAILLQI SKD in isoform 5.		VSP_010164
	Alternative sequence	1193 – 1341	149	Missing in isoform 6.		VSP_010165
	Alternative sequence	1245 – 1341	97	GSENG…SFAQH → AFPHYGCNFYGFRKWSCTEA SNTSPTMSAAQNAE in isoform 2 and isoform 3.		VSP_010163
	Natural variant	21	1	P → S. Ref.4 Corresponds to variant rs35391761 [ dbSNP | Ensembl ].		VAR_040886
	Natural variant	185	1	R → H. Ref.4 Corresponds to variant rs55911154 [ dbSNP | Ensembl ].		VAR_040887
	Natural variant	267	1	N → S. Ref.4 Corresponds to variant rs34509373 [ dbSNP | Ensembl ].		VAR_040888
	Natural variant	275	1	I → V. Ref.4 Corresponds to variant rs10209102 [ dbSNP | Ensembl ].		VAR_030605
	Natural variant	309	1	K → E. Ref.3 Ref.4 Corresponds to variant rs4668246 [ dbSNP | Ensembl ].		VAR_030606
	Natural variant	316	1	H → L. Ref.4 Corresponds to variant rs55633190 [ dbSNP | Ensembl ].		VAR_040889
	Natural variant	352	1	E → Q. Ref.4 Corresponds to variant rs56179904 [ dbSNP | Ensembl ].		VAR_040890
	Natural variant	388	1	N → S. Ref.4 Corresponds to variant rs34273653 [ dbSNP | Ensembl ].		VAR_040891
	Natural variant	406	1	A → T. Ref.4 Corresponds to variant rs10168181 [ dbSNP | Ensembl ].		VAR_030607
	Natural variant	638	1	Q → P. Ref.4 Corresponds to variant rs55911627 [ dbSNP | Ensembl ].		VAR_040892
	Natural variant	770	1	V → I. Ref.3 Ref.4 Corresponds to variant rs6736609 [ dbSNP | Ensembl ].		VAR_030608
	Natural variant	773	1	E → G. Ref.3 Ref.4 Corresponds to variant rs33962844 [ dbSNP | Ensembl ].		VAR_040893
	Natural variant	798	1	E → K. Corresponds to variant rs11892763 [ dbSNP | Ensembl ].		VAR_030609
	Natural variant	918	1	R → Q. Ref.4 Corresponds to variant rs55769829 [ dbSNP | Ensembl ].		VAR_040894
	Natural variant	969	1	S → C. Ref.4 Corresponds to variant rs35857918 [ dbSNP | Ensembl ].		VAR_040895
	Natural variant	990	1	R → C. Ref.4 Corresponds to variant rs34236931 [ dbSNP | Ensembl ].		VAR_040896
	Natural variant	1082	1	R → K. Ref.1 Ref.3 Corresponds to variant rs10185178 [ dbSNP | Ensembl ].		VAR_030610
	Natural variant	1092	1	I → V. Ref.4 Corresponds to variant rs34219776 [ dbSNP | Ensembl ].		VAR_040897
	Natural variant	1137	1	V → I. Ref.4 Corresponds to variant rs34546065 [ dbSNP | Ensembl ].		VAR_040898
	Natural variant	1165	1	R → C. Ref.4 Corresponds to variant rs56052422 [ dbSNP | Ensembl ].		VAR_040899
Experimental info
	Sequence conflict	261	1	K → R in BAB71011. Ref.3
	Sequence conflict	573	1	T → A in BAB71011. Ref.3
	Sequence conflict	870	1	K → M in AAL57233. Ref.1
	Sequence conflict	870	1	K → M in AAO13799. Ref.1
	Sequence conflict	870	1	K → M in AAO13800. Ref.1
	Sequence conflict	870	1	K → M in AAO13801. Ref.1
	Sequence conflict	870	1	K → M in AAO13802. Ref.1
	Sequence conflict	870	1	K → M in AAO13803. Ref.1
	Sequence conflict	1081	1	K → N in BAB71011. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (MYO3B.2) [UniParc]. Last modified May 18, 2010. Version 4. Checksum: 76F84C571DAA269D	FASTA	1,341	151,829
	10 20 30 40 50 60 MKHLYGLFHY NPMMLGLESL PDPTDTWEII ETIGKGTYGK VYKVTNKRDG SLAAVKILDP 70 80 90 100 110 120 VSDMDEEIEA EYNILQFLPN HPNVVKFYGM FYKADHCVGG QLWLVLELCN GGSVTELVKG 130 140 150 160 170 180 LLRCGQRLDE AMISYILYGA LLGLQHLHNN RIIHRDVKGN NILLTTEGGV KLVDFGVSAQ 190 200 210 220 230 240 LTSTRLRRNT SVGTPFWMAP EVIACEQQYD SSYDARCDVW SLGITAIELG DGDPPLFDMH 250 260 270 280 290 300 PVKTLFKIPR NPPPTLLHPE KWCEEFNHFI SQCLIKDFER RPSVTHLLDH PFIKGVHGKV 310 320 330 340 350 360 LFLQKQLAKV LQDQKHQNPV AKTRHERMHT RRPYHVEDAE KYCLEDDLVN LEVLDEDTII 370 380 390 400 410 420 HQLQKRYADL LIYTYVGDIL IALNPFQNLS IYSPQFSRLY HGVKRASNPP HIFASADAAY 430 440 450 460 470 480 QCMVTLSKDQ CIVISGESGS GKTESAHLIV QHLTFLGKAN NQTLREKILQ VNSLVEAFGN 490 500 510 520 530 540 SCTAINDNSS RFGKYLEMMF TPTGVVMGAR ISEYLLEKSR VIKQAAREKN FHIFYYIYAG 550 560 570 580 590 600 LHHQKKLSDF RLPEEKPPRY IADETGRVMH DITSKESYRR QFEAIQHCFR IIGFTDKEVH 610 620 630 640 650 660 SVYRILAGIL NIGNIEFAAI SSQHQTDKSE VPNAEALQNA ASVLCISPEE LQEALTSHCV 670 680 690 700 710 720 VTRGETIIRA NTVDRAADVR DAMSKALYGR LFSWIVNRIN TLLQPDENIC SAGGGMNVGI 730 740 750 760 770 780 LDIFGFENFQ RNSFEQLCIN IANEQIQYYF NQHVFALEQM EYQNEGIDAV PVEYEDNRPL 790 800 810 820 830 840 LDMFLQKPLG LLALLDEESR FPQATDQTLV DKFEDNLRCK YFWRPKGVEL CFGIQHYAGK 850 860 870 880 890 900 VLYDASGVLE KNRDTLPADV VVVLRTSENK LLQQLFSIPL TKTGNLAQTR ARITVASSSL 910 920 930 940 950 960 PPHFSAGKAK VDTLEVIRHP EETTNMKRQT VASYFRYSLM DLLSKMVVGQ PHFVRCIKPN 970 980 990 1000 1010 1020 DDREALQFSR ERVLAQLRST GILETVSIRR QGYSHRILFE EFVKRYYYLA FTAHQTPLAS 1030 1040 1050 1060 1070 1080 KESCVAILEK SRLDHWVLGK TKVFLKYYHV EQLNLLLREV IGRVVVLQAY TKGWLGARRY 1090 1100 1110 1120 1130 1140 KRVREKREKG AIAIQSAWRG YDARRKFKKI SNRRNESAAH NQAGDTSNQS SGPHSPVAAG 1150 1160 1170 1180 1190 1200 TRGSAEVQDC SEPGDHKVLR GSVHRRSHSQ AESNNGRTQT SSNSPAVTEK NGHSQAQSSP 1210 1220 1230 1240 1250 1260 KGCDIFAGHA NKHSVSGTDL LSSRICHPAP DQQGLSLWGA PQKPGSENGL AQKHRTPRRR 1270 1280 1290 1300 1310 1320 CQQPKMLSSP EDTMYYNQLN GTLEYQGSKR KPRKLGQIKV LDGEDEYYKS LSPVDCIPEE 1330 1340 NNSAHPSFFS SSSKGDSFAQ H
	Isoform 2 (MYO3B.0) [UniParc]. Checksum: 08890776C830E4A2	FASTA	1,278	144,595
	10 20 30 40 50 60 MKHLYGLFHY NPMMLGLESL PDPTDTWEII ETIGKGTYGK VYKVTNKRDG SLAAVKILDP 70 80 90 100 110 120 VSDMDEEIEA EYNILQFLPN HPNVVKFYGM FYKADHCVGG QLWLVLELCN GGSVTELVKG 130 140 150 160 170 180 LLRCGQRLDE AMISYILYGA LLGLQHLHNN RIIHRDVKGN NILLTTEGGV KLVDFGVSAQ 190 200 210 220 230 240 LTSTRLRRNT SVGTPFWMAP EVIACEQQYD SSYDARCDVW SLGITAIELG DGDPPLFDMH 250 260 270 280 290 300 PVKTLFKIPR NPPPTLLHPE KWCEEFNHFI SQCLIKDFER RPSVTHLLDH PFIKGVHGKV 310 320 330 340 350 360 LFLQKQLAKV LQDQKHQNPV AKTRHERMHT RRPYHVEDAE KYCLEDDLVN LEVLDEDTII 370 380 390 400 410 420 HQLQKRYADL LIYTYVGDIL IALNPFQNLS IYSPQFSRLY HGVKRASNPP HIFASADAAY 430 440 450 460 470 480 QCMVTLSKDQ CIVISGESGS GKTESAHLIV QHLTFLGKAN NQTLREKILQ VNSLVEAFGN 490 500 510 520 530 540 SCTAINDNSS RFGKYLEMMF TPTGVVMGAR ISEYLLEKSR VIKQAAREKN FHIFYYIYAG 550 560 570 580 590 600 LHHQKKLSDF RLPEEKPPRY IADETGRVMH DITSKESYRR QFEAIQHCFR IIGFTDKEVH 610 620 630 640 650 660 SVYRILAGIL NIGNIEFAAI SSQHQTDKSE VPNAEALQNA ASVLCISPEE LQEALTSHCV 670 680 690 700 710 720 VTRGETIIRA NTVDRAADVR DAMSKALYGR LFSWIVNRIN TLLQPDENIC SAGGGMNVGI 730 740 750 760 770 780 LDIFGFENFQ RNSFEQLCIN IANEQIQYYF NQHVFALEQM EYQNEGIDAV PVEYEDNRPL 790 800 810 820 830 840 LDMFLQKPLG LLALLDEESR FPQATDQTLV DKFEDNLRCK YFWRPKGVEL CFGIQHYAGK 850 860 870 880 890 900 VLYDASGVLE KNRDTLPADV VVVLRTSENK LLQQLFSIPL TKTGNLAQTR ARITVASSSL 910 920 930 940 950 960 PPHFSAGKAK VDTLEVIRHP EETTNMKRQT VASYFRYSLM DLLSKMVVGQ PHFVRCIKPN 970 980 990 1000 1010 1020 DDREALQFSR ERVLAQLRST GILETVSIRR QGYSHRILFE EFVKRYYYLA FTAHQTPLAS 1030 1040 1050 1060 1070 1080 KESCVAILEK SRLDHWVLGK TKVFLKYYHV EQLNLLLREV IGRVVVLQAY TKGWLGARRY 1090 1100 1110 1120 1130 1140 KRVREKREKG AIAIQSAWRG YDARRKFKKI SNRRNESAAH NQAGDTSNQS SGPHSPVAAG 1150 1160 1170 1180 1190 1200 TRGSAEVQDC SEPGDHKVLR GSVHRRSHSQ AESNNGRTQT SSNSPAVTEK NGHSQAQSSP 1210 1220 1230 1240 1250 1260 KGCDIFAGHA NKHSVSGTDL LSSRICHPAP DQQGLSLWGA PQKPAFPHYG CNFYGFRKWS 1270 CTEASNTSPT MSAAQNAE
	Isoform 3 (MYO3B.1) [UniParc]. Checksum: 361E5B30B7EC31A9	FASTA	1,251	141,381
	10 20 30 40 50 60 MKHLYGLFHY NPMMLGLESL PDPTDTWEII ETIGKGTYGK VYKVTNKRDG SLAAVKILDP 70 80 90 100 110 120 VSDMDEEIEA EYNILQFLPN HPNVVKFYGM FYKADHCVGG QLWLVLELCN GGSVTELVKG 130 140 150 160 170 180 LLRCGQRLDE AMISYILYGA LLGLQHLHNN RIIHRDVKGN NILLTTEGGV KLVDFGVSAQ 190 200 210 220 230 240 LTSTRLRRNT SVGTPFWMAP EVIACEQQYD SSYDARCDVW SLGITAIELG DGDPPLFDMH 250 260 270 280 290 300 PVKTLFKIPR NPPPTLLHPE KWCEEFNHFI SQCLIKDFER RPSVTHLLDH PFIKGVHGKV 310 320 330 340 350 360 LFLQKQLAKV LQDQKHQNPV AKTRHERMHT RRPYHVEDAE KYCLEDDLVN LEVLDEDTII 370 380 390 400 410 420 HQLQKRYADL LIYTYVGDIL IALNPFQNLS IYSPQFSRLY HGVKRASNPP HIFASADAAY 430 440 450 460 470 480 QCMVTLSKDQ CIVISGESGS GKTESAHLIV QHLTFLGKAN NQTLREKILQ VNSLVEAFGN 490 500 510 520 530 540 SCTAINDNSS RFGKYLEMMF TPTGVVMGAR ISEYLLEKSR VIKQAAREKN FHIFYYIYAG 550 560 570 580 590 600 LHHQKKLSDF RLPEEKPPRY IADETGRVMH DITSKESYRR QFEAIQHCFR IIGFTDKEVH 610 620 630 640 650 660 SVYRILAGIL NIGNIEFAAI SSQHQTDKSE VPNAEALQNA ASVLCISPEE LQEALTSHCV 670 680 690 700 710 720 VTRGETIIRA NTVDRAADVR DAMSKALYGR LFSWIVNRIN TLLQPDENIC SAGGGMNVGI 730 740 750 760 770 780 LDIFGFENFQ RNSFEQLCIN IANEQIQYYF NQHVFALEQM EYQNEGIDAV PVEYEDNRPL 790 800 810 820 830 840 LDMFLQKPLG LLALLDEESR FPQATDQTLV DKFEDNLRCK YFWRPKGVEL CFGIQHYAGK 850 860 870 880 890 900 VLYDASGVLE KNRDTLPADV VVVLRTSENK LLQQLFSIPL TKTGNLAQTR ARITVASSSL 910 920 930 940 950 960 PPHFSAGKAK VDTLEVIRHP EETTNMKRQT VASYFRYSLM DLLSKMVVGQ PHFVRCIKPN 970 980 990 1000 1010 1020 DDREALQFSR ERVLAQLRST GILETVSIRR QGYSHRILFE EFVKRYYYLA FTAHQTPLAS 1030 1040 1050 1060 1070 1080 KESCVAILEK SRLDHWVLGK TKVFLKYYHV EQLNLLLREV IGRVVVLQAY TKGWLGARRY 1090 1100 1110 1120 1130 1140 KRVREKREKG AIAIQSGDTS NQSSGPHSPV AAGTRGSAEV QDCSEPGDHK VLRGSVHRRS 1150 1160 1170 1180 1190 1200 HSQAESNNGR TQTSSNSPAV TEKNGHSQAQ SSPKGCDIFA GHANKHSVSG TDLLSSRICH 1210 1220 1230 1240 1250 PAPDQQGLSL WGAPQKPAFP HYGCNFYGFR KWSCTEASNT SPTMSAAQNA E
	Isoform 4 (MYO3B.3) [UniParc]. Checksum: F3A4479775B9C11B	FASTA	1,314	148,615
	10 20 30 40 50 60 MKHLYGLFHY NPMMLGLESL PDPTDTWEII ETIGKGTYGK VYKVTNKRDG SLAAVKILDP 70 80 90 100 110 120 VSDMDEEIEA EYNILQFLPN HPNVVKFYGM FYKADHCVGG QLWLVLELCN GGSVTELVKG 130 140 150 160 170 180 LLRCGQRLDE AMISYILYGA LLGLQHLHNN RIIHRDVKGN NILLTTEGGV KLVDFGVSAQ 190 200 210 220 230 240 LTSTRLRRNT SVGTPFWMAP EVIACEQQYD SSYDARCDVW SLGITAIELG DGDPPLFDMH 250 260 270 280 290 300 PVKTLFKIPR NPPPTLLHPE KWCEEFNHFI SQCLIKDFER RPSVTHLLDH PFIKGVHGKV 310 320 330 340 350 360 LFLQKQLAKV LQDQKHQNPV AKTRHERMHT RRPYHVEDAE KYCLEDDLVN LEVLDEDTII 370 380 390 400 410 420 HQLQKRYADL LIYTYVGDIL IALNPFQNLS IYSPQFSRLY HGVKRASNPP HIFASADAAY 430 440 450 460 470 480 QCMVTLSKDQ CIVISGESGS GKTESAHLIV QHLTFLGKAN NQTLREKILQ VNSLVEAFGN 490 500 510 520 530 540 SCTAINDNSS RFGKYLEMMF TPTGVVMGAR ISEYLLEKSR VIKQAAREKN FHIFYYIYAG 550 560 570 580 590 600 LHHQKKLSDF RLPEEKPPRY IADETGRVMH DITSKESYRR QFEAIQHCFR IIGFTDKEVH 610 620 630 640 650 660 SVYRILAGIL NIGNIEFAAI SSQHQTDKSE VPNAEALQNA ASVLCISPEE LQEALTSHCV 670 680 690 700 710 720 VTRGETIIRA NTVDRAADVR DAMSKALYGR LFSWIVNRIN TLLQPDENIC SAGGGMNVGI 730 740 750 760 770 780 LDIFGFENFQ RNSFEQLCIN IANEQIQYYF NQHVFALEQM EYQNEGIDAV PVEYEDNRPL 790 800 810 820 830 840 LDMFLQKPLG LLALLDEESR FPQATDQTLV DKFEDNLRCK YFWRPKGVEL CFGIQHYAGK 850 860 870 880 890 900 VLYDASGVLE KNRDTLPADV VVVLRTSENK LLQQLFSIPL TKTGNLAQTR ARITVASSSL 910 920 930 940 950 960 PPHFSAGKAK VDTLEVIRHP EETTNMKRQT VASYFRYSLM DLLSKMVVGQ PHFVRCIKPN 970 980 990 1000 1010 1020 DDREALQFSR ERVLAQLRST GILETVSIRR QGYSHRILFE EFVKRYYYLA FTAHQTPLAS 1030 1040 1050 1060 1070 1080 KESCVAILEK SRLDHWVLGK TKVFLKYYHV EQLNLLLREV IGRVVVLQAY TKGWLGARRY 1090 1100 1110 1120 1130 1140 KRVREKREKG AIAIQSGDTS NQSSGPHSPV AAGTRGSAEV QDCSEPGDHK VLRGSVHRRS 1150 1160 1170 1180 1190 1200 HSQAESNNGR TQTSSNSPAV TEKNGHSQAQ SSPKGCDIFA GHANKHSVSG TDLLSSRICH 1210 1220 1230 1240 1250 1260 PAPDQQGLSL WGAPQKPGSE NGLAQKHRTP RRRCQQPKML SSPEDTMYYN QLNGTLEYQG 1270 1280 1290 1300 1310 SKRKPRKLGQ IKVLDGEDEY YKSLSPVDCI PEENNSAHPS FFSSSSKGDS FAQH
	Isoform 5 (MYO3B.4) [UniParc]. Checksum: 5FA002DEC199A3B1	FASTA	1,275	144,329
	10 20 30 40 50 60 MKHLYGLFHY NPMMLGLESL PDPTDTWEII ETIGKGTYGK VYKVTNKRDG SLAAVKILDP 70 80 90 100 110 120 VSDMDEEIEA EYNILQFLPN HPNVVKFYGM FYKADHCVGG QLWLVLELCN GGSVTELVKG 130 140 150 160 170 180 LLRCGQRLDE AMISYILYGA LLGLQHLHNN RIIHRDVKGN NILLTTEGGV KLVDFGVSAQ 190 200 210 220 230 240 LTSTRLRRNT SVGTPFWMAP EVIACEQQYD SSYDARCDVW SLGITAIELG DGDPPLFDMH 250 260 270 280 290 300 PVKTLFKIPR NPPPTLLHPE KWCEEFNHFI SQCLIKDFER RPSVTHLLDH PFIKGVHGKV 310 320 330 340 350 360 LFLQKQLAKV LQDQKHQNPV AKTRHERMHT RRPYHVEDAE KYCLEDDLVN LEVLDEDTII 370 380 390 400 410 420 HQLQKRYADL LIYTYVGDIL IALNPFQNLS IYSPQFSRLY HGVKRASNPP HIFASADAAY 430 440 450 460 470 480 QCMVTLSKDQ CIVISGESGS GKTESAHLIV QHLTFLGKAN NQTLREKILQ VNSLVEAFGN 490 500 510 520 530 540 SCTAINDNSS RFGKYLEMMF TPTGVVMGAR ISEYLLEKSR VIKQAAREKN FHIFYYIYAG 550 560 570 580 590 600 LHHQKKLSDF RLPEEKPPRY IADETGRVMH DITSKESYRR QFEAIQHCFR IIGFTDKEVH 610 620 630 640 650 660 SVYRILAGIL NIGNIEFAAI SSQHQTDKSE VPNAEALQNA ASVLCISPEE LQEALTSHCV 670 680 690 700 710 720 VTRGETIIRA NTVDRAADVR DAMSKALYGR LFSWIVNRIN TLLQPDENIC SAGGGMNVGI 730 740 750 760 770 780 LDIFGFENFQ RNSFEQLCIN IANEQIQYYF NQHVFALEQM EYQNEGIDAV PVEYEDNRPL 790 800 810 820 830 840 LDMFLQKPLG LLALLDEESR FPQATDQTLV DKFEDNLRCK YFWRPKGVEL CFGIQHYAGK 850 860 870 880 890 900 VLYDASGVLE KNRDTLPADV VVVLRTSENK LLQQLFSIPL TKTGNLAQTR ARITVASSSL 910 920 930 940 950 960 PPHFSAGKAK VDTLEVIRHP EETTNMKRQT VASYFRYSLM DLLSKMVVGQ PHFVRCIKPN 970 980 990 1000 1010 1020 DDREALQFSR ERVLAQLRST GILETVSIRR QGYSHRILFE EFVKRYYYLA FTAHQTPLAS 1030 1040 1050 1060 1070 1080 KESCVAILEK SRLDHWVLGK TKVFLKYYHV EQLNLLLREV IGRVVVLQAY TKGWLGARRY 1090 1100 1110 1120 1130 1140 KRVREKREKG AIAIQSAWRG YDARRKFKKI SNRRNESAAH NQAGDTSNQS SGPHSPVAAG 1150 1160 1170 1180 1190 1200 TRGSAEVQDC SEPGDHKVLR GSVHRRSHSQ AESNNGRTQT SSNSPAVTEK NGWSFTLLLR 1210 1220 1230 1240 1250 1260 LECNSMISAD CNLRPLGSSD SPASASRVAG ITGIHKPRVL QKGAISSQDM QTSTRFLGLI 1270 CCLLGYAILL QISKD
	Isoform 6 (MYO3B.5) [UniParc]. Checksum: 28488BBC7CD00706	FASTA	1,192	135,407
	10 20 30 40 50 60 MKHLYGLFHY NPMMLGLESL PDPTDTWEII ETIGKGTYGK VYKVTNKRDG SLAAVKILDP 70 80 90 100 110 120 VSDMDEEIEA EYNILQFLPN HPNVVKFYGM FYKADHCVGG QLWLVLELCN GGSVTELVKG 130 140 150 160 170 180 LLRCGQRLDE AMISYILYGA LLGLQHLHNN RIIHRDVKGN NILLTTEGGV KLVDFGVSAQ 190 200 210 220 230 240 LTSTRLRRNT SVGTPFWMAP EVIACEQQYD SSYDARCDVW SLGITAIELG DGDPPLFDMH 250 260 270 280 290 300 PVKTLFKIPR NPPPTLLHPE KWCEEFNHFI SQCLIKDFER RPSVTHLLDH PFIKGVHGKV 310 320 330 340 350 360 LFLQKQLAKV LQDQKHQNPV AKTRHERMHT RRPYHVEDAE KYCLEDDLVN LEVLDEDTII 370 380 390 400 410 420 HQLQKRYADL LIYTYVGDIL IALNPFQNLS IYSPQFSRLY HGVKRASNPP HIFASADAAY 430 440 450 460 470 480 QCMVTLSKDQ CIVISGESGS GKTESAHLIV QHLTFLGKAN NQTLREKILQ VNSLVEAFGN 490 500 510 520 530 540 SCTAINDNSS RFGKYLEMMF TPTGVVMGAR ISEYLLEKSR VIKQAAREKN FHIFYYIYAG 550 560 570 580 590 600 LHHQKKLSDF RLPEEKPPRY IADETGRVMH DITSKESYRR QFEAIQHCFR IIGFTDKEVH 610 620 630 640 650 660 SVYRILAGIL NIGNIEFAAI SSQHQTDKSE VPNAEALQNA ASVLCISPEE LQEALTSHCV 670 680 690 700 710 720 VTRGETIIRA NTVDRAADVR DAMSKALYGR LFSWIVNRIN TLLQPDENIC SAGGGMNVGI 730 740 750 760 770 780 LDIFGFENFQ RNSFEQLCIN IANEQIQYYF NQHVFALEQM EYQNEGIDAV PVEYEDNRPL 790 800 810 820 830 840 LDMFLQKPLG LLALLDEESR FPQATDQTLV DKFEDNLRCK YFWRPKGVEL CFGIQHYAGK 850 860 870 880 890 900 VLYDASGVLE KNRDTLPADV VVVLRTSENK LLQQLFSIPL TKTGNLAQTR ARITVASSSL 910 920 930 940 950 960 PPHFSAGKAK VDTLEVIRHP EETTNMKRQT VASYFRYSLM DLLSKMVVGQ PHFVRCIKPN 970 980 990 1000 1010 1020 DDREALQFSR ERVLAQLRST GILETVSIRR QGYSHRILFE EFVKRYYYLA FTAHQTPLAS 1030 1040 1050 1060 1070 1080 KESCVAILEK SRLDHWVLGK TKVFLKYYHV EQLNLLLREV IGRVVVLQAY TKGWLGARRY 1090 1100 1110 1120 1130 1140 KRVREKREKG AIAIQSAWRG YDARRKFKKI SNRRNESAAH NQAGDTSNQS SGPHSPVAAG 1150 1160 1170 1180 1190 TRGSAEVQDC SEPGDHKVLR GSVHRRSHSQ AESNNGRTQT SSNSPAVTEK NG
	Isoform 7 [UniParc]. Checksum: 4DFD8DBA81A82CBE	FASTA	1,350	152,799
	10 20 30 40 50 60 MLQSALLSTR KHLYGLFHYN PMMLGLESLP DPTDTWEIIE TIGKGTYGKV YKVTNKRDGS 70 80 90 100 110 120 LAAVKILDPV SDMDEEIEAE YNILQFLPNH PNVVKFYGMF YKADHCVGGQ LWLVLELCNG 130 140 150 160 170 180 GSVTELVKGL LRCGQRLDEA MISYILYGAL LGLQHLHNNR IIHRDVKGNN ILLTTEGGVK 190 200 210 220 230 240 LVDFGVSAQL TSTRLRRNTS VGTPFWMAPE VIACEQQYDS SYDARCDVWS LGITAIELGD 250 260 270 280 290 300 GDPPLFDMHP VKTLFKIPRN PPPTLLHPEK WCEEFNHFIS QCLIKDFERR PSVTHLLDHP 310 320 330 340 350 360 FIKGVHGKVL FLQKQLAKVL QDQKHQNPVA KTRHERMHTR RPYHVEDAEK YCLEDDLVNL 370 380 390 400 410 420 EVLDEDTIIH QLQKRYADLL IYTYVGDILI ALNPFQNLSI YSPQFSRLYH GVKRASNPPH 430 440 450 460 470 480 IFASADAAYQ CMVTLSKDQC IVISGESGSG KTESAHLIVQ HLTFLGKANN QTLREKILQV 490 500 510 520 530 540 NSLVEAFGNS CTAINDNSSR FGKYLEMMFT PTGVVMGARI SEYLLEKSRV IKQAAREKNF 550 560 570 580 590 600 HIFYYIYAGL HHQKKLSDFR LPEEKPPRYI ADETGRVMHD ITSKESYRRQ FEAIQHCFRI 610 620 630 640 650 660 IGFTDKEVHS VYRILAGILN IGNIEFAAIS SQHQTDKSEV PNAEALQNAA SVLCISPEEL 670 680 690 700 710 720 QEALTSHCVV TRGETIIRAN TVDRAADVRD AMSKALYGRL FSWIVNRINT LLQPDENICS 730 740 750 760 770 780 AGGGMNVGIL DIFGFENFQR NSFEQLCINI ANEQIQYYFN QHVFALEQME YQNEGIDAVP 790 800 810 820 830 840 VEYEDNRPLL DMFLQKPLGL LALLDEESRF PQATDQTLVD KFEDNLRCKY FWRPKGVELC 850 860 870 880 890 900 FGIQHYAGKV LYDASGVLEK NRDTLPADVV VVLRTSENKL LQQLFSIPLT KTGNLAQTRA 910 920 930 940 950 960 RITVASSSLP PHFSAGKAKV DTLEVIRHPE ETTNMKRQTV ASYFRYSLMD LLSKMVVGQP 970 980 990 1000 1010 1020 HFVRCIKPND DREALQFSRE RVLAQLRSTG ILETVSIRRQ GYSHRILFEE FVKRYYYLAF 1030 1040 1050 1060 1070 1080 TAHQTPLASK ESCVAILEKS RLDHWVLGKT KVFLKYYHVE QLNLLLREVI GRVVVLQAYT 1090 1100 1110 1120 1130 1140 KGWLGARRYK RVREKREKGA IAIQSAWRGY DARRKFKKIS NRRNESAAHN QAGDTSNQSS 1150 1160 1170 1180 1190 1200 GPHSPVAAGT RGSAEVQDCS EPGDHKVLRG SVHRRSHSQA ESNNGRTQTS SNSPAVTEKN 1210 1220 1230 1240 1250 1260 GHSQAQSSPK GCDIFAGHAN KHSVSGTDLL SSRICHPAPD QQGLSLWGAP QKPGSENGLA 1270 1280 1290 1300 1310 1320 QKHRTPRRRC QQPKMLSSPE DTMYYNQLNG TLEYQGSKRK PRKLGQIKVL DGEDEYYKSL 1330 1340 1350 SPVDCIPEEN NSAHPSFFSS SSKGDSFAQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A class III myosin expressed in the retina is a potential candidate for Bardet-Biedl syndrome." Dose A.C., Burnside B. Genomics 79:621-624(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), ALTERNATIVE SPLICING, VARIANT LYS-1082.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1104 (ISOFORM 7), VARIANTS GLU-309; ILE-770; GLY-773 AND LYS-1082. Tissue: Kidney.
[4]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-21; HIS-185; SER-267; VAL-275; GLU-309; LEU-316; GLN-352; SER-388; THR-406; PRO-638; ILE-770; GLY-773; GLN-918; CYS-969; CYS-990; VAL-1092; ILE-1137 AND CYS-1165.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF369908 mRNA. Translation: AAL57233.1. AF391554 mRNA. Translation: AAO13799.1. AF391555 mRNA. Translation: AAO13800.1. AF391556 mRNA. Translation: AAO13801.1. AF391557 mRNA. Translation: AAO13802.1. AF391558 mRNA. Translation: AAO13803.1. AC007277 Genomic DNA. No translation available. AC012594 Genomic DNA. Translation: AAY24324.1. AC068280 Genomic DNA. No translation available. AC093402 Genomic DNA. No translation available. AC114794 Genomic DNA. Translation: AAY24159.1. AK055778 mRNA. Translation: BAB71011.1.
IPI	IPI00179193. IPI00217417. IPI00337720. IPI00385322. IPI00409999. IPI00827784. IPI00956214.
RefSeq	NP_001077084.2. NM_001083615.3. NP_620482.3. NM_138995.4.
UniGene	Hs.671900.
3D structure databases
ProteinModelPortal	Q8WXR4.
SMR	Q8WXR4. Positions 15-332, 335-1105.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WXR4. 4 interactions.
PTM databases
PhosphoSite	Q8WXR4.
Polymorphism databases
DMDM	296439486.
Proteomic databases
PaxDb	Q8WXR4.
PRIDE	Q8WXR4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317935; ENSP00000314650; ENSG00000071909. ENST00000334231; ENSP00000335100; ENSG00000071909. ENST00000408978; ENSP00000386213; ENSG00000071909. ENST00000409044; ENSP00000386497; ENSG00000071909.
GeneID	140469.
KEGG	hsa:140469.
UCSC	uc002ufv.3. human. uc002ufz.3. human. uc010fqb.1. human.
Organism-specific databases
CTD	140469.
GeneCards	GC02P170998.
H-InvDB	HIX0002580.
HGNC	HGNC:15576. MYO3B.
MIM	610040. gene.
neXtProt	NX_Q8WXR4.
PharmGKB	PA31406.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG052555.
InParanoid	Q8WXR4.
KO	K08834.
OMA	GEDEYYK.
OrthoDB	EOG490785.
Gene expression databases
ArrayExpress	Q8WXR4.
Bgee	Q8WXR4.
Genevestigator	Q8WXR4.
GermOnline	ENSG00000071909. Homo sapiens.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR011009. Kinase-like_dom. IPR001609. Myosin_head_motor_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00612. IQ. 1 hit. PF00063. Myosin_head. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00015. IQ. 2 hits. SM00242. MYSc. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50096. IQ. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL5654.
GenomeRNAi	140469.
NextBio	84146.
SOURCE	Search...

Entry information

Entry name

MYO3B_HUMAN

Accession

Primary (citable) accession number: Q8WXR4
Secondary accession number(s): B8ZZR2 , Q53QE1, Q53T08, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68, Q96N94

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 105 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.