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Q8WXQ8 (CBPA5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase A5

EC=3.4.17.-
Gene names
Name:CPA5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expression is very low or not detectable.

Sequence similarities

Belongs to the peptidase M14 family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionCarboxypeptidase
Hydrolase
Metalloprotease
Protease
   PTMCleavage on pair of basic residues
Disulfide bond
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetallocarboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WXQ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WXQ8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     347-351: YDLAK → VRLAA
     352-436: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8WXQ8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     347-436: YDLAKDAVEA...IMEHTLNHPY → MWPVGSPSTG...WRFGPSWSTP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Propeptide34 – 12693Activation peptide By similarity
PRO_0000004361
Chain127 – 436310Carboxypeptidase A5
PRO_0000004362

Regions

Region196 – 1994Substrate binding By similarity
Region271 – 2722Substrate binding By similarity
Region324 – 3252Substrate binding By similarity

Sites

Active site3971Nucleophile By similarity
Metal binding1961Zinc; catalytic By similarity
Metal binding1991Zinc; catalytic By similarity
Metal binding3231Zinc; catalytic By similarity
Binding site2541Substrate By similarity

Amino acid modifications

Disulfide bond265 ↔ 288 By similarity

Natural variations

Alternative sequence347 – 43690YDLAK…LNHPY → MWPVGSPSTGPMTVASSTPS ALSSGTLGSMASCCRPHRSS PRPRRRGWRFGPSWSTP in isoform 3.
VSP_044866
Alternative sequence347 – 3515YDLAK → VRLAA in isoform 2.
VSP_008806
Alternative sequence352 – 43685Missing in isoform 2.
VSP_008807
Natural variant791P → S. Ref.1
Corresponds to variant rs17388190 [ dbSNP | Ensembl ].
VAR_017191
Natural variant3361L → S. Ref.1 Ref.6
Corresponds to variant rs11761888 [ dbSNP | Ensembl ].
VAR_017192
Natural variant3381E → D. Ref.1 Ref.6
Corresponds to variant rs17854248 [ dbSNP | Ensembl ].
VAR_017193
Natural variant3781S → G.
Corresponds to variant rs11765961 [ dbSNP | Ensembl ].
VAR_048596

Experimental info

Sequence conflict1081K → R in BAC04122. Ref.3
Sequence conflict1171E → G in AAH39362. Ref.6
Sequence conflict2931H → R in BAD18389. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: A6EB4FFDE72F355A

FASTA43649,036
        10         20         30         40         50         60 
MQGTPGGGTR PGPSPVDRRT LLVFSFILAA ALGQMNFTGD QVLRVLAKDE KQLSLLGDLE 

        70         80         90        100        110        120 
GLKPQKVDFW RGPARPSLPV DMRVPFSELK DIKAYLESHG LAYSIMIKDI QVLLDEERQA 

       130        140        150        160        170        180 
MAKSRRLERS TNSFSYSSYH TLEEIYSWID NFVMEHSDIV SKIQIGNSFE NQSILVLKFS 

       190        200        210        220        230        240 
TGGSRHPAIW IDTGIHSREW ITHATGIWTA NKIVSDYGKD RVLTDILNAM DIFIELVTNP 

       250        260        270        280        290        300 
DGFAFTHSMN RLWRKNKSIR PGIFCIGVDL NRNWKSGFGG NGSNSNPCSE TYHGPSPQSE 

       310        320        330        340        350        360 
PEVAAIVNFI TAHGNFKALI SIHSYSQMLM YPYGRLLEPV SNQRELYDLA KDAVEALYKV 

       370        380        390        400        410        420 
HGIEYIFGSI STTLYVASGI TVDWAYDSGI KYAFSFELRD TGQYGFLLPA TQIIPTAQET 

       430 
WMALRTIMEH TLNHPY 

« Hide

Isoform 2 [UniParc].

Checksum: 9D083276FD2D6B16
Show »

FASTA35139,364
Isoform 3 [UniParc].

Checksum: 3C8467B533BAB019
Show »

FASTA40344,881

References

« Hide 'large scale' references
[1]"Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region."
Bonora E., Bacchelli E., Levy E.R., Blasi F., Marlow A., Monaco A.P., Maestrini E.
Mol. Psychiatry 7:289-301(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-79; SER-336 AND ASP-338.
[2]"The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome."
Bentley L., Nakabayashi K., Monk D., Beechey C., Peters J., Birjandi Z., Khayat F.E., Patel M., Preece M.A., Stanier P., Scherer S.W., Moore G.E.
J. Med. Genet. 40:249-256(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Medulla oblongata.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Testis.
[4]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-336 AND ASP-338.
Tissue: Testis.
[7]"Identification and characterization of three members of the human metallocarboxypeptidase gene family."
Wei S., Segura S., Vendrell J., Aviles F.X., Lanoue E., Day R., Feng Y., Fricker L.D.
J. Biol. Chem. 277:14954-14964(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE STRUCTURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF384667 mRNA. Translation: AAL37611.1.
AY155229 mRNA. Translation: AAO17155.1.
AY155230 mRNA. Translation: AAO17156.1.
AK093288 mRNA. Translation: BAC04122.1.
AK131191 mRNA. Translation: BAD18389.1.
AC007938 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83757.1.
BC039362 mRNA. Translation: AAH39362.1.
BC042996 mRNA. Translation: AAH42996.1.
BK000187 mRNA. Translation: DAA00035.1.
CCDSCCDS47713.1. [Q8WXQ8-3]
CCDS5819.1. [Q8WXQ8-1]
RefSeqNP_001120913.1. NM_001127441.1. [Q8WXQ8-1]
NP_001120914.1. NM_001127442.1. [Q8WXQ8-3]
NP_525124.3. NM_080385.4. [Q8WXQ8-1]
XP_005250767.1. XM_005250710.1. [Q8WXQ8-1]
XP_005250768.1. XM_005250711.1. [Q8WXQ8-1]
XP_005250769.1. XM_005250712.1. [Q8WXQ8-1]
XP_006716241.1. XM_006716178.1. [Q8WXQ8-3]
UniGeneHs.567642.

3D structure databases

ProteinModelPortalQ8WXQ8.
SMRQ8WXQ8. Positions 37-436.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000347549.

Chemistry

BindingDBQ8WXQ8.

Protein family/group databases

MEROPSM14.020.

Polymorphism databases

DMDM38257690.

Proteomic databases

PaxDbQ8WXQ8.
PRIDEQ8WXQ8.

Protocols and materials databases

DNASU93979.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355388; ENSP00000347549; ENSG00000158525. [Q8WXQ8-1]
ENST00000393213; ENSP00000376907; ENSG00000158525. [Q8WXQ8-1]
ENST00000431780; ENSP00000393045; ENSG00000158525. [Q8WXQ8-3]
ENST00000461828; ENSP00000418183; ENSG00000158525. [Q8WXQ8-1]
ENST00000466363; ENSP00000419025; ENSG00000158525. [Q8WXQ8-1]
ENST00000474905; ENSP00000417314; ENSG00000158525. [Q8WXQ8-1]
ENST00000485477; ENSP00000420237; ENSG00000158525. [Q8WXQ8-1]
ENST00000579032; ENSP00000464444; ENSG00000266292. [Q8WXQ8-1]
ENST00000579725; ENSP00000462245; ENSG00000266292. [Q8WXQ8-1]
ENST00000582999; ENSP00000462551; ENSG00000266292. [Q8WXQ8-1]
ENST00000583967; ENSP00000464290; ENSG00000266292. [Q8WXQ8-1]
ENST00000583996; ENSP00000463370; ENSG00000266292. [Q8WXQ8-1]
ENST00000584835; ENSP00000464329; ENSG00000266292. [Q8WXQ8-3]
GeneID93979.
KEGGhsa:93979.
UCSCuc003vps.2. human. [Q8WXQ8-1]
uc003vpt.2. human.

Organism-specific databases

CTD93979.
GeneCardsGC07P129986.
HGNCHGNC:15722. CPA5.
HPAHPA020322.
MIM609561. gene.
neXtProtNX_Q8WXQ8.
PharmGKBPA26820.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2866.
HOGENOMHOG000252967.
HOVERGENHBG050815.
InParanoidQ8WXQ8.
KOK08781.
OMAVHGIEYI.
PhylomeDBQ8WXQ8.
TreeFamTF317197.

Gene expression databases

ArrayExpressQ8WXQ8.
BgeeQ8WXQ8.
CleanExHS_CPA5.
GenevestigatorQ8WXQ8.

Family and domain databases

Gene3D3.30.70.340. 1 hit.
InterProIPR000834. Peptidase_M14.
IPR003146. Prot_inh_M14A.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSPR00765. CRBOXYPTASEA.
SMARTSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMSSF54897. SSF54897. 1 hit.
PROSITEPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCPA5.
GenomeRNAi93979.
NextBio78246.
PROQ8WXQ8.
SOURCESearch...

Entry information

Entry nameCBPA5_HUMAN
AccessionPrimary (citable) accession number: Q8WXQ8
Secondary accession number(s): G3V0G8 expand/collapse secondary AC list , Q6ZNI6, Q86SE2, Q86XM3, Q8NA08
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM