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Protein

Carboxypeptidase A5

Gene

CPA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi196Zinc; catalyticBy similarity1
Metal bindingi199Zinc; catalyticBy similarity1
Binding sitei254SubstrateBy similarity1
Metal bindingi323Zinc; catalyticBy similarity1
Binding sitei375SubstrateBy similarity1
Active sitei397Proton donor/acceptorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS08305-MONOMER.

Protein family/group databases

MEROPSiM14.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase A5 (EC:3.4.17.-)
Gene namesi
Name:CPA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15722. CPA5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi93979.
OpenTargetsiENSG00000158525.
PharmGKBiPA26820.

Polymorphism and mutation databases

BioMutaiCPA5.
DMDMi38257690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
PropeptideiPRO_000000436134 – 126Activation peptideBy similarityAdd BLAST93
ChainiPRO_0000004362127 – 436Carboxypeptidase A5Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi265 ↔ 288By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ8WXQ8.
PeptideAtlasiQ8WXQ8.
PRIDEiQ8WXQ8.
TopDownProteomicsiQ8WXQ8-1. [Q8WXQ8-1]

PTM databases

iPTMnetiQ8WXQ8.
PhosphoSitePlusiQ8WXQ8.

Expressioni

Tissue specificityi

Expression is very low or not detectable.

Gene expression databases

BgeeiENSG00000158525.
CleanExiHS_CPA5.
ExpressionAtlasiQ8WXQ8. baseline and differential.
GenevisibleiQ8WXQ8. HS.

Organism-specific databases

HPAiHPA020322.

Interactioni

Protein-protein interaction databases

BioGridi125066. 14 interactors.
STRINGi9606.ENSP00000347549.

Structurei

3D structure databases

ProteinModelPortaliQ8WXQ8.
SMRiQ8WXQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 199Substrate bindingBy similarity4
Regioni271 – 272Substrate bindingBy similarity2
Regioni324 – 325Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252967.
HOVERGENiHBG050815.
InParanoidiQ8WXQ8.
KOiK08781.
OMAiWRKNKSI.
OrthoDBiEOG091G0HUI.
PhylomeDBiQ8WXQ8.
TreeFamiTF317197.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR003146. M14A_act_pep.
IPR000834. Peptidase_M14.
IPR009020. Propept_inh.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQGTPGGGTR PGPSPVDRRT LLVFSFILAA ALGQMNFTGD QVLRVLAKDE
60 70 80 90 100
KQLSLLGDLE GLKPQKVDFW RGPARPSLPV DMRVPFSELK DIKAYLESHG
110 120 130 140 150
LAYSIMIKDI QVLLDEERQA MAKSRRLERS TNSFSYSSYH TLEEIYSWID
160 170 180 190 200
NFVMEHSDIV SKIQIGNSFE NQSILVLKFS TGGSRHPAIW IDTGIHSREW
210 220 230 240 250
ITHATGIWTA NKIVSDYGKD RVLTDILNAM DIFIELVTNP DGFAFTHSMN
260 270 280 290 300
RLWRKNKSIR PGIFCIGVDL NRNWKSGFGG NGSNSNPCSE TYHGPSPQSE
310 320 330 340 350
PEVAAIVNFI TAHGNFKALI SIHSYSQMLM YPYGRLLEPV SNQRELYDLA
360 370 380 390 400
KDAVEALYKV HGIEYIFGSI STTLYVASGI TVDWAYDSGI KYAFSFELRD
410 420 430
TGQYGFLLPA TQIIPTAQET WMALRTIMEH TLNHPY
Length:436
Mass (Da):49,036
Last modified:March 1, 2002 - v1
Checksum:iA6EB4FFDE72F355A
GO
Isoform 2 (identifier: Q8WXQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-351: YDLAK → VRLAA
     352-436: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,364
Checksum:i9D083276FD2D6B16
GO
Isoform 3 (identifier: Q8WXQ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-436: YDLAKDAVEA...IMEHTLNHPY → MWPVGSPSTG...WRFGPSWSTP

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):44,881
Checksum:i3C8467B533BAB019
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108K → R in BAC04122 (PubMed:14702039).Curated1
Sequence conflicti117E → G in AAH39362 (PubMed:15489334).Curated1
Sequence conflicti293H → R in BAD18389 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01719179P → S.1 PublicationCorresponds to variant rs17388190dbSNPEnsembl.1
Natural variantiVAR_017192336L → S.2 PublicationsCorresponds to variant rs11761888dbSNPEnsembl.1
Natural variantiVAR_017193338E → D.2 PublicationsCorresponds to variant rs17854248dbSNPEnsembl.1
Natural variantiVAR_048596378S → G.Corresponds to variant rs11765961dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044866347 – 436YDLAK…LNHPY → MWPVGSPSTGPMTVASSTPS ALSSGTLGSMASCCRPHRSS PRPRRRGWRFGPSWSTP in isoform 3. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_008806347 – 351YDLAK → VRLAA in isoform 2. 1 Publication5
Alternative sequenceiVSP_008807352 – 436Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384667 mRNA. Translation: AAL37611.1.
AY155229 mRNA. Translation: AAO17155.1.
AY155230 mRNA. Translation: AAO17156.1.
AK093288 mRNA. Translation: BAC04122.1.
AK131191 mRNA. Translation: BAD18389.1.
AC007938 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83757.1.
BC039362 mRNA. Translation: AAH39362.1.
BC042996 mRNA. Translation: AAH42996.1.
BK000187 mRNA. Translation: DAA00035.1.
CCDSiCCDS47713.1. [Q8WXQ8-3]
CCDS5819.1. [Q8WXQ8-1]
RefSeqiNP_001120913.1. NM_001127441.1. [Q8WXQ8-1]
NP_001120914.1. NM_001127442.1. [Q8WXQ8-3]
NP_001305152.1. NM_001318223.1. [Q8WXQ8-1]
NP_525124.3. NM_080385.4. [Q8WXQ8-1]
XP_005250767.1. XM_005250710.1. [Q8WXQ8-1]
XP_005250769.1. XM_005250712.1. [Q8WXQ8-1]
XP_011515000.1. XM_011516698.1. [Q8WXQ8-1]
XP_011515003.1. XM_011516701.1. [Q8WXQ8-1]
XP_011515004.1. XM_011516702.1. [Q8WXQ8-1]
XP_011515005.1. XM_011516703.1. [Q8WXQ8-1]
XP_011515006.1. XM_011516704.1. [Q8WXQ8-3]
UniGeneiHs.567642.

Genome annotation databases

EnsembliENST00000393213; ENSP00000376907; ENSG00000158525. [Q8WXQ8-1]
ENST00000431780; ENSP00000393045; ENSG00000158525. [Q8WXQ8-3]
ENST00000461828; ENSP00000418183; ENSG00000158525. [Q8WXQ8-1]
ENST00000466363; ENSP00000419025; ENSG00000158525. [Q8WXQ8-1]
ENST00000474905; ENSP00000417314; ENSG00000158525. [Q8WXQ8-1]
ENST00000485477; ENSP00000420237; ENSG00000158525. [Q8WXQ8-1]
GeneIDi93979.
KEGGihsa:93979.
UCSCiuc003vps.3. human. [Q8WXQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384667 mRNA. Translation: AAL37611.1.
AY155229 mRNA. Translation: AAO17155.1.
AY155230 mRNA. Translation: AAO17156.1.
AK093288 mRNA. Translation: BAC04122.1.
AK131191 mRNA. Translation: BAD18389.1.
AC007938 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83757.1.
BC039362 mRNA. Translation: AAH39362.1.
BC042996 mRNA. Translation: AAH42996.1.
BK000187 mRNA. Translation: DAA00035.1.
CCDSiCCDS47713.1. [Q8WXQ8-3]
CCDS5819.1. [Q8WXQ8-1]
RefSeqiNP_001120913.1. NM_001127441.1. [Q8WXQ8-1]
NP_001120914.1. NM_001127442.1. [Q8WXQ8-3]
NP_001305152.1. NM_001318223.1. [Q8WXQ8-1]
NP_525124.3. NM_080385.4. [Q8WXQ8-1]
XP_005250767.1. XM_005250710.1. [Q8WXQ8-1]
XP_005250769.1. XM_005250712.1. [Q8WXQ8-1]
XP_011515000.1. XM_011516698.1. [Q8WXQ8-1]
XP_011515003.1. XM_011516701.1. [Q8WXQ8-1]
XP_011515004.1. XM_011516702.1. [Q8WXQ8-1]
XP_011515005.1. XM_011516703.1. [Q8WXQ8-1]
XP_011515006.1. XM_011516704.1. [Q8WXQ8-3]
UniGeneiHs.567642.

3D structure databases

ProteinModelPortaliQ8WXQ8.
SMRiQ8WXQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125066. 14 interactors.
STRINGi9606.ENSP00000347549.

Protein family/group databases

MEROPSiM14.020.

PTM databases

iPTMnetiQ8WXQ8.
PhosphoSitePlusiQ8WXQ8.

Polymorphism and mutation databases

BioMutaiCPA5.
DMDMi38257690.

Proteomic databases

PaxDbiQ8WXQ8.
PeptideAtlasiQ8WXQ8.
PRIDEiQ8WXQ8.
TopDownProteomicsiQ8WXQ8-1. [Q8WXQ8-1]

Protocols and materials databases

DNASUi93979.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393213; ENSP00000376907; ENSG00000158525. [Q8WXQ8-1]
ENST00000431780; ENSP00000393045; ENSG00000158525. [Q8WXQ8-3]
ENST00000461828; ENSP00000418183; ENSG00000158525. [Q8WXQ8-1]
ENST00000466363; ENSP00000419025; ENSG00000158525. [Q8WXQ8-1]
ENST00000474905; ENSP00000417314; ENSG00000158525. [Q8WXQ8-1]
ENST00000485477; ENSP00000420237; ENSG00000158525. [Q8WXQ8-1]
GeneIDi93979.
KEGGihsa:93979.
UCSCiuc003vps.3. human. [Q8WXQ8-1]

Organism-specific databases

CTDi93979.
DisGeNETi93979.
GeneCardsiCPA5.
HGNCiHGNC:15722. CPA5.
HPAiHPA020322.
MIMi609561. gene.
neXtProtiNX_Q8WXQ8.
OpenTargetsiENSG00000158525.
PharmGKBiPA26820.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252967.
HOVERGENiHBG050815.
InParanoidiQ8WXQ8.
KOiK08781.
OMAiWRKNKSI.
OrthoDBiEOG091G0HUI.
PhylomeDBiQ8WXQ8.
TreeFamiTF317197.

Enzyme and pathway databases

BioCyciZFISH:HS08305-MONOMER.

Miscellaneous databases

GeneWikiiCPA5.
GenomeRNAii93979.
PROiQ8WXQ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158525.
CleanExiHS_CPA5.
ExpressionAtlasiQ8WXQ8. baseline and differential.
GenevisibleiQ8WXQ8. HS.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR003146. M14A_act_pep.
IPR000834. Peptidase_M14.
IPR009020. Propept_inh.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPA5_HUMAN
AccessioniPrimary (citable) accession number: Q8WXQ8
Secondary accession number(s): G3V0G8
, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.