ID   Q8WXL0_HUMAN            Unreviewed;       136 AA.
AC   Q8WXL0;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=Luteinizing hormone beta subunit {ECO:0000313|EMBL:AAL69719.1};
DE   Flags: Fragment;
GN   Name=LHB {ECO:0000313|EMBL:AAL69719.1};
GN   Synonyms=hLHB {ECO:0000313|EMBL:AAL69719.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAL69719.1};
RN   [1] {ECO:0000313|EMBL:AAL69719.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11861891;
RA   Maston G.A., Ruvolo M.;
RT   "Chorionic gonadotropin has a recent origin within primates and an
RT   evolutionary history of selection.";
RL   Mol. Biol. Evol. 19:320-335(2002).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU004069}.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000256|ARBA:ARBA00006552, ECO:0000256|RuleBase:RU004069}.
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DR   EMBL; AF397591; AAL69719.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8WXL0; -.
DR   SMR; Q8WXL0; -.
DR   PeptideAtlas; Q8WXL0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1.
DR   PANTHER; PTHR11515:SF11; LUTROPIN SUBUNIT BETA; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   3: Inferred from homology;
KW   Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU004069};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..136
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012768289"
FT   DOMAIN          22..125
FT                   /note="Glycoprotein hormone subunit beta"
FT                   /evidence="ECO:0000259|Pfam:PF00007"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAL69719.1"
SQ   SEQUENCE   136 AA;  14712 MW;  FE5451852A45054E CRC64;
     GLLLLLLLSM GGAWASREPL RPWCHPINAI LAVEKEGCPV CITVNTTICA GYCPTMMRVL
     QAVLPPLPQV VCTYRDVRFE SIRLPGCPRG VDPVVSFPVA LSCRCGPCRR STSDCGGPKD
     HPLTCDHPQL SGLLFL
//