Reviewed, UniProtKB/Swiss-Prot Q8WXK4 (ASB12_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat and SOCS box protein 12
      Short name=ASB-12

Gene names

Name:

ASB12

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with CUL5 and RNF7. Ref.4
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.
Sequence similarities	Contains 5 ANK repeats. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Domain	ANK repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Ankyrin repeat and SOCS box protein 12		PRO_0000066947
Regions
	Repeat	63 – 92	30	ANK 1
	Repeat	96 – 125	30	ANK 2
	Repeat	129 – 158	30	ANK 3
	Repeat	171 – 200	30	ANK 4
	Repeat	213 – 243	31	ANK 5
	Domain	268 – 308	41	SOCS box

Sequences

	Sequence		Length	Mass (Da)
	Q8WXK4-1 [UniParc]. Last modified April 12, 2005. Version 2. Checksum: 8280C47C544D03D8	FASTA	309	33,943
	10 20 30 40 50 60 MNLMDITKIF SLLQPDKEEE DTDTEEKQAL NQAVYDNDSY TLDQLLRQER YKRFINSRSG 70 80 90 100 110 120 WGVPGTPLRL AASYGHLSCL QVLLAHGADV DSLDVKAQTP LFTAVSHGHL DCVRVLLEAG 130 140 150 160 170 180 ASPGGSIYNN CSPVLTAARD GAVAILQELL DHGAEANVKA KLPVWASNIA SCSGPLYLAA 190 200 210 220 230 240 VYGHLDCFRL LLLHGADPDY NCTDQGLLAR VPRPRTLLEI CLHHNCEPEY IQLLIDFGAN 250 260 270 280 290 300 IYLPSLSLDL TSQDDKGIAL LLQARATPRS LLSQVRLVVR RALCQAGQPQ AINQLDIPPM LISYLKHQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SOCS box proteins." Kile B.T., Nicola N.A. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-308.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes." Kohroki J., Nishiyama T., Nakamura T., Masuho Y. FEBS Lett. 579:6796-6802(2005) [PubMed: 16325183] [Abstract] Cited for: FUNCTION AS A E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL5 AND RNF7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF403030 mRNA. Translation: AAL57349.1. AL356317 Genomic DNA. Translation: CAI39932.1. BC069436 mRNA. Translation: AAH69436.1. BC069555 mRNA. Translation: AAH69555.1. BC093883 mRNA. Translation: AAH93883.1. BC104946 mRNA. Translation: AAI04947.1.
IPI	IPI00298157.
RefSeq	NP_569059.2.
UniGene	Hs.56281
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WXK4.
Proteomic databases
PRIDE	Q8WXK4.
Genome annotation databases
Ensembl	ENST00000362002; ENSP00000355195; ENSG00000198881; Homo sapiens. [Genome view] ENST00000396130; ENSP00000379435; ENSG00000198881; Homo sapiens. [Genome view] ENST00000453546; ENSP00000394003; ENSG00000198881; Homo sapiens. [Genome view]
GeneID	142689.
KEGG	hsa:142689.
UCSC	uc004dvp.1. human.
Organism-specific databases
CTD	142689.
GeneCards	GC0XM063360.
HGNC	HGNC:19763. ASB12.
PharmGKB	PA134937084.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8WXK4.
OMA	TAVSHGH
OrthoDB	EOG95TG6Q
Gene expression databases
ArrayExpress	Q8WXK4.
Bgee	Q8WXK4.
CleanEx	HS_ASB12.
Genevestigator	Q8WXK4.
GermOnline	ENSG00000198881. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001496. SOCS_C. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 5 hits. PF07525. SOCS_box. 1 hit. [Graphical view]
SMART	SM00248. ANK. 5 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. PS50225. SOCS. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	84621.

Entry information

Entry name

ASB12_HUMAN

Accession

Primary (citable) accession number: Q8WXK4
Secondary accession number(s): Q2M3D5, Q52LK4, Q6ISF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	April 12, 2005
Last modified:	November 24, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.