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Q8WXK4

- ASB12_HUMAN

UniProt

Q8WXK4 - ASB12_HUMAN

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Protein

Ankyrin repeat and SOCS box protein 12

Gene

ASB12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 12
Short name:
ASB-12
Gene namesi
Name:ASB12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:19763. ASB12.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937084.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Ankyrin repeat and SOCS box protein 12PRO_0000066947Add
BLAST

Proteomic databases

PRIDEiQ8WXK4.

Expressioni

Gene expression databases

BgeeiQ8WXK4.
CleanExiHS_ASB12.
GenevestigatoriQ8WXK4.

Organism-specific databases

HPAiHPA049542.

Interactioni

Subunit structurei

Interacts with CUL5 and RNF7.1 Publication

Protein-protein interaction databases

BioGridi126776. 28 interactions.
IntActiQ8WXK4. 2 interactions.
MINTiMINT-1500389.
STRINGi9606.ENSP00000355195.

Structurei

3D structure databases

ProteinModelPortaliQ8WXK4.
SMRiQ8WXK4. Positions 20-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati63 – 9230ANK 1Add
BLAST
Repeati96 – 12530ANK 2Add
BLAST
Repeati129 – 15830ANK 3Add
BLAST
Repeati171 – 20030ANK 4Add
BLAST
Repeati213 – 24331ANK 5Add
BLAST
Domaini268 – 30841SOCS boxAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00730000110500.
HOVERGENiHBG107089.
InParanoidiQ8WXK4.
KOiK10334.
OrthoDBiEOG7TXKGW.
PhylomeDBiQ8WXK4.
TreeFamiTF331945.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WXK4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLMDITKIF SLLQPDKEEE DTDTEEKQAL NQAVYDNDSY TLDQLLRQER
60 70 80 90 100
YKRFINSRSG WGVPGTPLRL AASYGHLSCL QVLLAHGADV DSLDVKAQTP
110 120 130 140 150
LFTAVSHGHL DCVRVLLEAG ASPGGSIYNN CSPVLTAARD GAVAILQELL
160 170 180 190 200
DHGAEANVKA KLPVWASNIA SCSGPLYLAA VYGHLDCFRL LLLHGADPDY
210 220 230 240 250
NCTDQGLLAR VPRPRTLLEI CLHHNCEPEY IQLLIDFGAN IYLPSLSLDL
260 270 280 290 300
TSQDDKGIAL LLQARATPRS LLSQVRLVVR RALCQAGQPQ AINQLDIPPM

LISYLKHQL
Length:309
Mass (Da):33,943
Last modified:April 12, 2005 - v2
Checksum:i8280C47C544D03D8
GO
Isoform 2 (identifier: Q8WXK4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRIVLQLAKM

Note: No experimental confirmation available.

Show »
Length:318
Mass (Da):34,996
Checksum:iD2EA9DD3E66E73DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491L → P in BAC04888. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRIVLQLAKM in isoform 2. 1 PublicationVSP_044865

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF403030 mRNA. Translation: AAL57349.1.
AK096896 mRNA. Translation: BAC04888.1.
AL356317 Genomic DNA. Translation: CAI39932.1.
CH471132 Genomic DNA. Translation: EAX05414.1.
BC069436 mRNA. Translation: AAH69436.1.
BC069555 mRNA. Translation: AAH69555.1.
BC093883 mRNA. Translation: AAH93883.1.
BC104946 mRNA. Translation: AAI04947.1.
CCDSiCCDS14378.2. [Q8WXK4-2]
RefSeqiNP_569059.3. NM_130388.3. [Q8WXK4-2]
UniGeneiHs.56281.

Genome annotation databases

EnsembliENST00000362002; ENSP00000355195; ENSG00000198881. [Q8WXK4-2]
GeneIDi142689.
KEGGihsa:142689.
UCSCiuc004dvq.3. human.

Polymorphism databases

DMDMi62512181.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF403030 mRNA. Translation: AAL57349.1 .
AK096896 mRNA. Translation: BAC04888.1 .
AL356317 Genomic DNA. Translation: CAI39932.1 .
CH471132 Genomic DNA. Translation: EAX05414.1 .
BC069436 mRNA. Translation: AAH69436.1 .
BC069555 mRNA. Translation: AAH69555.1 .
BC093883 mRNA. Translation: AAH93883.1 .
BC104946 mRNA. Translation: AAI04947.1 .
CCDSi CCDS14378.2. [Q8WXK4-2 ]
RefSeqi NP_569059.3. NM_130388.3. [Q8WXK4-2 ]
UniGenei Hs.56281.

3D structure databases

ProteinModelPortali Q8WXK4.
SMRi Q8WXK4. Positions 20-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126776. 28 interactions.
IntActi Q8WXK4. 2 interactions.
MINTi MINT-1500389.
STRINGi 9606.ENSP00000355195.

Polymorphism databases

DMDMi 62512181.

Proteomic databases

PRIDEi Q8WXK4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000362002 ; ENSP00000355195 ; ENSG00000198881 . [Q8WXK4-2 ]
GeneIDi 142689.
KEGGi hsa:142689.
UCSCi uc004dvq.3. human.

Organism-specific databases

CTDi 142689.
GeneCardsi GC0XM063444.
HGNCi HGNC:19763. ASB12.
HPAi HPA049542.
MIMi 300891. gene.
neXtProti NX_Q8WXK4.
PharmGKBi PA134937084.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00730000110500.
HOVERGENi HBG107089.
InParanoidi Q8WXK4.
KOi K10334.
OrthoDBi EOG7TXKGW.
PhylomeDBi Q8WXK4.
TreeFami TF331945.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii 142689.
NextBioi 35535067.
PROi Q8WXK4.
SOURCEi Search...

Gene expression databases

Bgeei Q8WXK4.
CleanExi HS_ASB12.
Genevestigatori Q8WXK4.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 5 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SOCS box proteins."
    Kile B.T., Nicola N.A.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-308 (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skeletal muscle.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes."
    Kohroki J., Nishiyama T., Nakamura T., Masuho Y.
    FEBS Lett. 579:6796-6802(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL5 AND RNF7.

Entry informationi

Entry nameiASB12_HUMAN
AccessioniPrimary (citable) accession number: Q8WXK4
Secondary accession number(s): J3KP57
, Q2M3D5, Q52LK4, Q6ISF9, Q8N8F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: April 12, 2005
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3