Q8WXK4 (ASB12_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 82.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ankyrin repeat and SOCS box protein 12 Short name=ASB-12 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 309 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity. Ref.4 |
| Pathway | |
| Subunit structure | Interacts with CUL5 and RNF7. Ref.4 |
| Domain | The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity. |
| Sequence similarities | Contains 5 ANK repeats. Contains 1 SOCS box domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Domain | ANK repeat Repeat |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | intracellular signal transduction Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 309 | 309 | Ankyrin repeat and SOCS box protein 12 | PRO_0000066947 | |||||
Regions | |||||||||
| Repeat | 63 – 92 | 30 | ANK 1 | ||||||
| Repeat | 96 – 125 | 30 | ANK 2 | ||||||
| Repeat | 129 – 158 | 30 | ANK 3 | ||||||
| Repeat | 171 – 200 | 30 | ANK 4 | ||||||
| Repeat | 213 – 243 | 31 | ANK 5 | ||||||
| Domain | 268 – 308 | 41 | SOCS box | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "SOCS box proteins." Kile B.T., Nicola N.A. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-308. |
| [2] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | "ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes." Kohroki J., Nishiyama T., Nakamura T., Masuho Y. FEBS Lett. 579:6796-6802(2005) [PubMed: 16325183] [Abstract] Cited for: FUNCTION AS A E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL5 AND RNF7. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF403030 mRNA. Translation: AAL57349.1. AL356317 Genomic DNA. Translation: CAI39932.1. BC069436 mRNA. Translation: AAH69436.1. BC069555 mRNA. Translation: AAH69555.1. BC093883 mRNA. Translation: AAH93883.1. BC104946 mRNA. Translation: AAI04947.1. |
| IPI | IPI01015787. |
| RefSeq | NP_569059.3. NM_130388.3. |
| UniGene | Hs.56281. |
3D structure databases | |
| ProteinModelPortal | Q8WXK4. |
| SMR | Q8WXK4. Positions 26-307. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-1500389. |
| STRING | Q8WXK4. |
Polymorphism databases | |
| DMDM | 62512181. |
Proteomic databases | |
| PRIDE | Q8WXK4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000362002; ENSP00000355195; ENSG00000198881. ENST00000396130; ENSP00000379435; ENSG00000198881. ENST00000453546; ENSP00000394003; ENSG00000198881. |
| GeneID | 142689. |
| KEGG | hsa:142689. |
| UCSC | uc004dvp.1. human. |
Organism-specific databases | |
| CTD | 142689. |
| GeneCards | GC0XM063444. |
| H-InvDB | HIX0016837. |
| HGNC | HGNC:19763. ASB12. |
| neXtProt | NX_Q8WXK4. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG15698. |
| GeneTree | ENSGT00550000074326. |
| HOVERGEN | HBG107089. |
| InParanoid | Q8WXK4. |
| OMA | GSIYNNC. |
| OrthoDB | EOG4B5P5S. |
| PhylomeDB | Q8WXK4. |
Enzyme and pathway databases | |
| Reactome | REACT_6900. Immune System. |
Gene expression databases | |
| ArrayExpress | Q8WXK4. |
| Bgee | Q8WXK4. |
| CleanEx | HS_ASB12. |
| Genevestigator | Q8WXK4. |
| GermOnline | ENSG00000198881. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001496. SOCS_C. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 1 hit. |
| KO | K10334. |
| Pfam | PF00023. Ank. 1 hit. PF12796. Ank_2. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view] |
| SMART | SM00248. ANK. 5 hits. SM00969. SOCS_box. 1 hit. [Graphical view] |
| SUPFAM | SSF48403. ANK. 1 hit. |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. PS50225. SOCS. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 84621. |
Entry information
| Entry name | ASB12_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8WXK4 Secondary accession number(s): Q2M3D5, Q52LK4, Q6ISF9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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