Q8WXK4 (ASB12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat and SOCS box protein 12
Short name=ASB-12

Gene names

Name:

ASB12

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity. Ref.4
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with CUL5 and RNF7. Ref.4
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.
Sequence similarities	Contains 5 ANK repeats. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Ankyrin repeat and SOCS box protein 12		PRO_0000066947
Regions
	Repeat	63 – 92	30	ANK 1
	Repeat	96 – 125	30	ANK 2
	Repeat	129 – 158	30	ANK 3
	Repeat	171 – 200	30	ANK 4
	Repeat	213 – 243	31	ANK 5
	Domain	268 – 308	41	SOCS box

Sequences

	Sequence		Length	Mass (Da)
	Q8WXK4 [UniParc]. Last modified April 12, 2005. Version 2. Checksum: 8280C47C544D03D8	FASTA	309	33,943
	10 20 30 40 50 60 MNLMDITKIF SLLQPDKEEE DTDTEEKQAL NQAVYDNDSY TLDQLLRQER YKRFINSRSG 70 80 90 100 110 120 WGVPGTPLRL AASYGHLSCL QVLLAHGADV DSLDVKAQTP LFTAVSHGHL DCVRVLLEAG 130 140 150 160 170 180 ASPGGSIYNN CSPVLTAARD GAVAILQELL DHGAEANVKA KLPVWASNIA SCSGPLYLAA 190 200 210 220 230 240 VYGHLDCFRL LLLHGADPDY NCTDQGLLAR VPRPRTLLEI CLHHNCEPEY IQLLIDFGAN 250 260 270 280 290 300 IYLPSLSLDL TSQDDKGIAL LLQARATPRS LLSQVRLVVR RALCQAGQPQ AINQLDIPPM LISYLKHQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SOCS box proteins." Kile B.T., Nicola N.A. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-308.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes." Kohroki J., Nishiyama T., Nakamura T., Masuho Y. FEBS Lett. 579:6796-6802(2005) [PubMed: 16325183] [Abstract] Cited for: FUNCTION AS A E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL5 AND RNF7.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF403030 mRNA. Translation: AAL57349.1. AL356317 Genomic DNA. Translation: CAI39932.1. BC069436 mRNA. Translation: AAH69436.1. BC069555 mRNA. Translation: AAH69555.1. BC093883 mRNA. Translation: AAH93883.1. BC104946 mRNA. Translation: AAI04947.1.
IPI	IPI01015787.
RefSeq	NP_569059.3. NM_130388.3.
UniGene	Hs.56281.
3D structure databases
ProteinModelPortal	Q8WXK4.
SMR	Q8WXK4. Positions 26-307.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1500389.
STRING	Q8WXK4.
Polymorphism databases
DMDM	62512181.
Proteomic databases
PRIDE	Q8WXK4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000362002; ENSP00000355195; ENSG00000198881. ENST00000396130; ENSP00000379435; ENSG00000198881. ENST00000453546; ENSP00000394003; ENSG00000198881.
GeneID	142689.
KEGG	hsa:142689.
UCSC	uc004dvp.1. human.
Organism-specific databases
CTD	142689.
GeneCards	GC0XM063444.
H-InvDB	HIX0016837.
HGNC	HGNC:19763. ASB12.
neXtProt	NX_Q8WXK4.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15698.
GeneTree	ENSGT00550000074326.
HOVERGEN	HBG107089.
InParanoid	Q8WXK4.
OMA	GSIYNNC.
OrthoDB	EOG4B5P5S.
PhylomeDB	Q8WXK4.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q8WXK4.
Bgee	Q8WXK4.
CleanEx	HS_ASB12.
Genevestigator	Q8WXK4.
GermOnline	ENSG00000198881. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001496. SOCS_C. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
KO	K10334.
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view]
SMART	SM00248. ANK. 5 hits. SM00969. SOCS_box. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. PS50225. SOCS. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	84621.

Entry information

Entry name

ASB12_HUMAN

Accession

Primary (citable) accession number: Q8WXK4
Secondary accession number(s): Q2M3D5, Q52LK4, Q6ISF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	April 12, 2005
Last modified:	January 25, 2012
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.