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Protein

Ankyrin repeat and SOCS box protein 13

Gene

ASB13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 13
Short name:
ASB-13
Gene namesi
Name:ASB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:19765. ASB13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992129.

Polymorphism and mutation databases

BioMutaiASB13.
DMDMi20531995.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Ankyrin repeat and SOCS box protein 13PRO_0000066949Add
BLAST

Proteomic databases

MaxQBiQ8WXK3.
PaxDbiQ8WXK3.
PRIDEiQ8WXK3.

PTM databases

PhosphoSiteiQ8WXK3.

Expressioni

Gene expression databases

BgeeiQ8WXK3.
CleanExiHS_ASB13.
GenevisibleiQ8WXK3. HS.

Organism-specific databases

HPAiHPA048293.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MARK3P274482EBI-707573,EBI-707595
VAC14Q08AM65EBI-707573,EBI-2107455
ZMIZ2Q8NF64-23EBI-707573,EBI-10182121

Protein-protein interaction databases

BioGridi122865. 17 interactions.
IntActiQ8WXK3. 8 interactions.
MINTiMINT-1416335.
STRINGi9606.ENSP00000350331.

Structurei

3D structure databases

ProteinModelPortaliQ8WXK3.
SMRiQ8WXK3. Positions 20-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 4730ANK 1Add
BLAST
Repeati51 – 8030ANK 2Add
BLAST
Repeati84 – 11330ANK 3Add
BLAST
Repeati116 – 14530ANK 4Add
BLAST
Repeati149 – 17830ANK 5Add
BLAST
Repeati181 – 21030ANK 6Add
BLAST
Domaini229 – 27850SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ8WXK3.
KOiK10335.
OMAiTFSPLHE.
OrthoDBiEOG7J447G.
PhylomeDBiQ8WXK3.
TreeFamiTF331945.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPRAADGCF LGDVGFWVER TPVHEAAQRG ESLQLQQLIE SGACVNQVTV
60 70 80 90 100
DSITPLHAAS LQGQARCVQL LLAAGAQVDA RNIDGSTPLC DACASGSIEC
110 120 130 140 150
VKLLLSYGAK VNPPLYTASP LHEACMSGSS ECVRLLIDVG ANLEAHDCHF
160 170 180 190 200
GTPLHVACAR EHLDCVKVLL NAGANVNAAK LHETALHHAA KVKNVDLIEM
210 220 230 240 250
LIEFGGNIYA RDNRGKKPSD YTWSSSAPAK CFEYYEKTPL TLSQLCRVNL
260 270
RKATGVRGLE KIAKLNIPPR LIDYLSYN
Length:278
Mass (Da):30,007
Last modified:May 10, 2002 - v2
Checksum:i6E54725A70AB32EF
GO
Isoform 2 (identifier: Q8WXK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: G → A
     174-278: Missing.

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):18,205
Checksum:i8F7BD794962D4AF4
GO

Sequence cautioni

The sequence AAL57350.1 differs from that shown. Reason: Frameshift at position 14. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041L → S in BAB14456 (PubMed:14702039).Curated
Sequence conflicti129 – 1291S → D in AAL57350 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei173 – 1731G → A in isoform 2. 1 PublicationVSP_000272
Alternative sequencei174 – 278105Missing in isoform 2. 1 PublicationVSP_000273Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403031 mRNA. Translation: AAL57350.1. Frameshift.
AK023196 mRNA. Translation: BAB14456.1.
AK292071 mRNA. Translation: BAF84760.1.
CR457302 mRNA. Translation: CAG33583.1.
AL365356 Genomic DNA. Translation: CAH72614.1.
CH471072 Genomic DNA. Translation: EAW86435.1.
CH471072 Genomic DNA. Translation: EAW86436.1.
BC012056 mRNA. Translation: AAH12056.1.
CCDSiCCDS7070.1. [Q8WXK3-1]
RefSeqiNP_078977.2. NM_024701.3. [Q8WXK3-1]
UniGeneiHs.445899.

Genome annotation databases

EnsembliENST00000357700; ENSP00000350331; ENSG00000196372. [Q8WXK3-1]
ENST00000459912; ENSP00000433358; ENSG00000196372. [Q8WXK3-2]
GeneIDi79754.
KEGGihsa:79754.
UCSCiuc001iig.3. human. [Q8WXK3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403031 mRNA. Translation: AAL57350.1. Frameshift.
AK023196 mRNA. Translation: BAB14456.1.
AK292071 mRNA. Translation: BAF84760.1.
CR457302 mRNA. Translation: CAG33583.1.
AL365356 Genomic DNA. Translation: CAH72614.1.
CH471072 Genomic DNA. Translation: EAW86435.1.
CH471072 Genomic DNA. Translation: EAW86436.1.
BC012056 mRNA. Translation: AAH12056.1.
CCDSiCCDS7070.1. [Q8WXK3-1]
RefSeqiNP_078977.2. NM_024701.3. [Q8WXK3-1]
UniGeneiHs.445899.

3D structure databases

ProteinModelPortaliQ8WXK3.
SMRiQ8WXK3. Positions 20-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122865. 17 interactions.
IntActiQ8WXK3. 8 interactions.
MINTiMINT-1416335.
STRINGi9606.ENSP00000350331.

PTM databases

PhosphoSiteiQ8WXK3.

Polymorphism and mutation databases

BioMutaiASB13.
DMDMi20531995.

Proteomic databases

MaxQBiQ8WXK3.
PaxDbiQ8WXK3.
PRIDEiQ8WXK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357700; ENSP00000350331; ENSG00000196372. [Q8WXK3-1]
ENST00000459912; ENSP00000433358; ENSG00000196372. [Q8WXK3-2]
GeneIDi79754.
KEGGihsa:79754.
UCSCiuc001iig.3. human. [Q8WXK3-1]

Organism-specific databases

CTDi79754.
GeneCardsiASB13.
HGNCiHGNC:19765. ASB13.
HPAiHPA048293.
MIMi615055. gene.
neXtProtiNX_Q8WXK3.
PharmGKBiPA134992129.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ8WXK3.
KOiK10335.
OMAiTFSPLHE.
OrthoDBiEOG7J447G.
PhylomeDBiQ8WXK3.
TreeFamiTF331945.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiASB13. human.
GeneWikiiASB13.
GenomeRNAii79754.
PROiQ8WXK3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WXK3.
CleanExiHS_ASB13.
GenevisibleiQ8WXK3. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SOCS box proteins."
    Kile B.T., Nicola N.A.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Stomach.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.

Entry informationi

Entry nameiASB13_HUMAN
AccessioniPrimary (citable) accession number: Q8WXK3
Secondary accession number(s): A8K7Q6
, D3DRR2, Q96EP7, Q9H8Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 10, 2002
Last modified: June 8, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.