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Q8WXK1

- ASB15_HUMAN

UniProt

Q8WXK1 - ASB15_HUMAN

Protein

Ankyrin repeat and SOCS box protein 15

Gene

ASB15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

    Pathwayi

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat and SOCS box protein 15
    Short name:
    ASB-15
    Gene namesi
    Name:ASB15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:19767. ASB15.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134977130.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588Ankyrin repeat and SOCS box protein 15PRO_0000066954Add
    BLAST

    Proteomic databases

    PaxDbiQ8WXK1.
    PRIDEiQ8WXK1.

    PTM databases

    PhosphoSiteiQ8WXK1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WXK1.
    BgeeiQ8WXK1.
    CleanExiHS_ASB15.
    GenevestigatoriQ8WXK1.

    Organism-specific databases

    HPAiHPA028853.

    Interactioni

    Protein-protein interaction databases

    BioGridi126774. 19 interactions.
    STRINGi9606.ENSP00000275699.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXK1.
    SMRiQ8WXK1. Positions 45-574.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati110 – 14233ANK 1Add
    BLAST
    Repeati143 – 17432ANK 2Add
    BLAST
    Repeati176 – 20833ANK 3Add
    BLAST
    Repeati209 – 24133ANK 4Add
    BLAST
    Repeati242 – 27433ANK 5Add
    BLAST
    Repeati307 – 33933ANK 6Add
    BLAST
    Repeati349 – 38032ANK 7Add
    BLAST
    Repeati381 – 41333ANK 8Add
    BLAST
    Repeati416 – 44429ANK 9Add
    BLAST
    Domaini524 – 57956SOCS boxPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

    Sequence similaritiesi

    Contains 9 ANK repeats.PROSITE-ProRule annotation
    Contains 1 SOCS box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000034086.
    HOVERGENiHBG023406.
    InParanoidiQ8WXK1.
    KOiK10337.
    OMAiAAYEGHY.
    OrthoDBiEOG7WQ7S1.
    PhylomeDBiQ8WXK1.
    TreeFamiTF315127.

    Family and domain databases

    Gene3Di1.25.40.20. 5 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001496. SOCS_C.
    [Graphical view]
    PfamiPF12796. Ank_2. 3 hits.
    PF07525. SOCS_box. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 9 hits.
    SM00969. SOCS_box. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 7 hits.
    PS50225. SOCS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WXK1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTNDDPDED HLTSYDIQLS IQESIEASKT ALCPERFVPL SAQNRKLVEA    50
    IKQGHIPELQ EYVKYKYAMD EADEKGWFPL HEAVVQPIQQ ILEIVLDASY 100
    KTLWEFKTCD GETPLTLAVK AGLVENVRTL LEKGVWPNTK NDKGETPLLI 150
    AVKKGSYDMV STLIKHNTSL DQPCVKRWSA MHEAAKQGRK DIVALLLKHG 200
    GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVLALA DDGASVLFEA 250
    AGGGNPDCIS LLLEYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS 300
    KNAIRKSGLT PIHSAADGQN AQCLELLIEN GFDVNTLLAD HISQSYDDER 350
    KTALYFGVSN NDVHCTEVLL AAGADPNLDP LNCLLVAVRA NNYEIVRLLL 400
    SHGANVNCYF MHVNDTRFPS VIQYALNDEV MLRLLLNNGY QVEMCFDCMH 450
    GDIFGNSFVW SEIQEEVLPG WTSCVIKDNP FCEFITVPWM KHLVGRVTRV 500
    LIDYMDYVPL CAKLKSALEV QREWPEIRQI LENPCSLKHL CRLKIRRLMG 550
    LQKLCQPASV EKLPLPPAIQ RYILFKEYDL YGQELKLT 588
    Length:588
    Mass (Da):65,799
    Last modified:May 18, 2010 - v3
    Checksum:iB3FD2435776B343D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti346 – 3461Y → C in BAC86146. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571P → L.2 Publications
    Corresponds to variant rs6962756 [ dbSNP | Ensembl ].
    VAR_060466
    Natural varianti357 – 3571G → A.2 Publications
    Corresponds to variant rs4731112 [ dbSNP | Ensembl ].
    VAR_060467

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125360 mRNA. Translation: BAC86146.1.
    AC006333 Genomic DNA. No translation available.
    BC100874 mRNA. Translation: AAI00875.1.
    BC100875 mRNA. Translation: AAI00876.1.
    BC100876 mRNA. Translation: AAI00877.1.
    BC100877 mRNA. Translation: AAI00878.1.
    CR749595 mRNA. Translation: CAH18393.1.
    AF403033 mRNA. Translation: AAL57352.1.
    CCDSiCCDS34742.1.
    RefSeqiNP_001277187.1. NM_001290258.1.
    NP_563616.3. NM_080928.4.
    XP_005250201.1. XM_005250144.2.
    XP_005250203.1. XM_005250146.2.
    XP_005250204.1. XM_005250147.2.
    UniGeneiHs.83916.

    Genome annotation databases

    EnsembliENST00000275699; ENSP00000275699; ENSG00000146809.
    ENST00000434204; ENSP00000390963; ENSG00000146809.
    ENST00000447789; ENSP00000401166; ENSG00000146809.
    ENST00000451215; ENSP00000416433; ENSG00000146809.
    ENST00000451558; ENSP00000397655; ENSG00000146809.
    ENST00000540573; ENSP00000438643; ENSG00000146809.
    GeneIDi142685.
    KEGGihsa:142685.
    UCSCiuc003vku.1. human.

    Polymorphism databases

    DMDMi296439431.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125360 mRNA. Translation: BAC86146.1 .
    AC006333 Genomic DNA. No translation available.
    BC100874 mRNA. Translation: AAI00875.1 .
    BC100875 mRNA. Translation: AAI00876.1 .
    BC100876 mRNA. Translation: AAI00877.1 .
    BC100877 mRNA. Translation: AAI00878.1 .
    CR749595 mRNA. Translation: CAH18393.1 .
    AF403033 mRNA. Translation: AAL57352.1 .
    CCDSi CCDS34742.1.
    RefSeqi NP_001277187.1. NM_001290258.1.
    NP_563616.3. NM_080928.4.
    XP_005250201.1. XM_005250144.2.
    XP_005250203.1. XM_005250146.2.
    XP_005250204.1. XM_005250147.2.
    UniGenei Hs.83916.

    3D structure databases

    ProteinModelPortali Q8WXK1.
    SMRi Q8WXK1. Positions 45-574.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126774. 19 interactions.
    STRINGi 9606.ENSP00000275699.

    PTM databases

    PhosphoSitei Q8WXK1.

    Polymorphism databases

    DMDMi 296439431.

    Proteomic databases

    PaxDbi Q8WXK1.
    PRIDEi Q8WXK1.

    Protocols and materials databases

    DNASUi 142685.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275699 ; ENSP00000275699 ; ENSG00000146809 .
    ENST00000434204 ; ENSP00000390963 ; ENSG00000146809 .
    ENST00000447789 ; ENSP00000401166 ; ENSG00000146809 .
    ENST00000451215 ; ENSP00000416433 ; ENSG00000146809 .
    ENST00000451558 ; ENSP00000397655 ; ENSG00000146809 .
    ENST00000540573 ; ENSP00000438643 ; ENSG00000146809 .
    GeneIDi 142685.
    KEGGi hsa:142685.
    UCSCi uc003vku.1. human.

    Organism-specific databases

    CTDi 142685.
    GeneCardsi GC07P123207.
    H-InvDB HIX0025283.
    HGNCi HGNC:19767. ASB15.
    HPAi HPA028853.
    neXtProti NX_Q8WXK1.
    PharmGKBi PA134977130.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000034086.
    HOVERGENi HBG023406.
    InParanoidi Q8WXK1.
    KOi K10337.
    OMAi AAYEGHY.
    OrthoDBi EOG7WQ7S1.
    PhylomeDBi Q8WXK1.
    TreeFami TF315127.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    GenomeRNAii 142685.
    NextBioi 84613.
    PROi Q8WXK1.

    Gene expression databases

    ArrayExpressi Q8WXK1.
    Bgeei Q8WXK1.
    CleanExi HS_ASB15.
    Genevestigatori Q8WXK1.

    Family and domain databases

    Gene3Di 1.25.40.20. 5 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001496. SOCS_C.
    [Graphical view ]
    Pfami PF12796. Ank_2. 3 hits.
    PF07525. SOCS_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 9 hits.
    SM00969. SOCS_box. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 7 hits.
    PS50225. SOCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-57 AND ALA-357.
      Tissue: Tongue.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-241, VARIANT LEU-57.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 62-588, VARIANT ALA-357.
      Tissue: Liver.
    5. "SOCS box proteins."
      Kile B.T., Nicola N.A.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-588.

    Entry informationi

    Entry nameiASB15_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXK1
    Secondary accession number(s): Q3ZCP3, Q3ZCP5, Q68D37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3