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Q8WXK1 (ASB15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat and SOCS box protein 15

Short name=ASB-15
Gene names
Name:ASB15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.

Pathway

Protein modification; protein ubiquitination.

Domain

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.

Sequence similarities

Contains 9 ANK repeats.

Contains 1 SOCS box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Coding sequence diversityPolymorphism
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Inferred from electronic annotation. Source: InterPro

protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588Ankyrin repeat and SOCS box protein 15
PRO_0000066954

Regions

Repeat110 – 14233ANK 1
Repeat143 – 17432ANK 2
Repeat176 – 20833ANK 3
Repeat209 – 24133ANK 4
Repeat242 – 27433ANK 5
Repeat307 – 33933ANK 6
Repeat349 – 38032ANK 7
Repeat381 – 41333ANK 8
Repeat416 – 44429ANK 9
Domain524 – 57956SOCS box

Natural variations

Natural variant571P → L. Ref.1 Ref.3
Corresponds to variant rs6962756 [ dbSNP | Ensembl ].
VAR_060466
Natural variant3571G → A. Ref.1 Ref.4
Corresponds to variant rs4731112 [ dbSNP | Ensembl ].
VAR_060467

Experimental info

Sequence conflict3461Y → C in BAC86146. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8WXK1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: B3FD2435776B343D

FASTA58865,799
        10         20         30         40         50         60 
MDTNDDPDED HLTSYDIQLS IQESIEASKT ALCPERFVPL SAQNRKLVEA IKQGHIPELQ 

        70         80         90        100        110        120 
EYVKYKYAMD EADEKGWFPL HEAVVQPIQQ ILEIVLDASY KTLWEFKTCD GETPLTLAVK 

       130        140        150        160        170        180 
AGLVENVRTL LEKGVWPNTK NDKGETPLLI AVKKGSYDMV STLIKHNTSL DQPCVKRWSA 

       190        200        210        220        230        240 
MHEAAKQGRK DIVALLLKHG GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVLALA 

       250        260        270        280        290        300 
DDGASVLFEA AGGGNPDCIS LLLEYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS 

       310        320        330        340        350        360 
KNAIRKSGLT PIHSAADGQN AQCLELLIEN GFDVNTLLAD HISQSYDDER KTALYFGVSN 

       370        380        390        400        410        420 
NDVHCTEVLL AAGADPNLDP LNCLLVAVRA NNYEIVRLLL SHGANVNCYF MHVNDTRFPS 

       430        440        450        460        470        480 
VIQYALNDEV MLRLLLNNGY QVEMCFDCMH GDIFGNSFVW SEIQEEVLPG WTSCVIKDNP 

       490        500        510        520        530        540 
FCEFITVPWM KHLVGRVTRV LIDYMDYVPL CAKLKSALEV QREWPEIRQI LENPCSLKHL 

       550        560        570        580 
CRLKIRRLMG LQKLCQPASV EKLPLPPAIQ RYILFKEYDL YGQELKLT 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-57 AND ALA-357.
Tissue: Tongue.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-241, VARIANT LEU-57.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 62-588, VARIANT ALA-357.
Tissue: Liver.
[5]"SOCS box proteins."
Kile B.T., Nicola N.A.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-588.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK125360 mRNA. Translation: BAC86146.1.
AC006333 Genomic DNA. No translation available.
BC100874 mRNA. Translation: AAI00875.1.
BC100875 mRNA. Translation: AAI00876.1.
BC100876 mRNA. Translation: AAI00877.1.
BC100877 mRNA. Translation: AAI00878.1.
CR749595 mRNA. Translation: CAH18393.1.
AF403033 mRNA. Translation: AAL57352.1.
RefSeqNP_563616.3. NM_080928.3.
XP_005250201.1. XM_005250144.2.
XP_005250202.1. XM_005250145.2.
XP_005250203.1. XM_005250146.2.
XP_005250204.1. XM_005250147.2.
UniGeneHs.83916.

3D structure databases

ProteinModelPortalQ8WXK1.
SMRQ8WXK1. Positions 40-574.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000275699.

PTM databases

PhosphoSiteQ8WXK1.

Polymorphism databases

DMDM296439431.

Proteomic databases

PaxDbQ8WXK1.
PRIDEQ8WXK1.

Protocols and materials databases

DNASU142685.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000275699; ENSP00000275699; ENSG00000146809.
ENST00000434204; ENSP00000390963; ENSG00000146809.
ENST00000447789; ENSP00000401166; ENSG00000146809.
ENST00000451215; ENSP00000416433; ENSG00000146809.
ENST00000451558; ENSP00000397655; ENSG00000146809.
ENST00000540573; ENSP00000438643; ENSG00000146809.
GeneID142685.
KEGGhsa:142685.
UCSCuc003vku.1. human.

Organism-specific databases

CTD142685.
GeneCardsGC07P123207.
H-InvDBHIX0025283.
HGNCHGNC:19767. ASB15.
HPAHPA028853.
neXtProtNX_Q8WXK1.
PharmGKBPA134977130.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000034086.
HOVERGENHBG023406.
InParanoidQ8WXK1.
KOK10337.
OMAAAYEGHY.
OrthoDBEOG7WQ7S1.
PhylomeDBQ8WXK1.
TreeFamTF315127.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ8WXK1.
BgeeQ8WXK1.
CleanExHS_ASB15.
GenevestigatorQ8WXK1.

Family and domain databases

Gene3D1.25.40.20. 5 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 9 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 7 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi142685.
NextBio84613.
PROQ8WXK1.

Entry information

Entry nameASB15_HUMAN
AccessionPrimary (citable) accession number: Q8WXK1
Secondary accession number(s): Q3ZCP3, Q3ZCP5, Q68D37
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM