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Protein

Ankyrin repeat and SOCS box protein 15

Gene

ASB15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 15
Short name:
ASB-15
Gene namesi
Name:ASB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:19767. ASB15.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Ankyrin repeat and SOCS box protein 15PRO_0000066954Add
BLAST

Proteomic databases

PaxDbiQ8WXK1.
PRIDEiQ8WXK1.

PTM databases

PhosphoSiteiQ8WXK1.

Expressioni

Gene expression databases

BgeeiQ8WXK1.
CleanExiHS_ASB15.
ExpressionAtlasiQ8WXK1. baseline.
GenevestigatoriQ8WXK1.

Organism-specific databases

HPAiHPA028853.

Interactioni

Protein-protein interaction databases

BioGridi126774. 19 interactions.
STRINGi9606.ENSP00000275699.

Structurei

3D structure databases

ProteinModelPortaliQ8WXK1.
SMRiQ8WXK1. Positions 45-574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati110 – 14233ANK 1Add
BLAST
Repeati143 – 17432ANK 2Add
BLAST
Repeati176 – 20833ANK 3Add
BLAST
Repeati209 – 24133ANK 4Add
BLAST
Repeati242 – 27433ANK 5Add
BLAST
Repeati307 – 33933ANK 6Add
BLAST
Repeati349 – 38032ANK 7Add
BLAST
Repeati381 – 41333ANK 8Add
BLAST
Repeati416 – 44429ANK 9Add
BLAST
Domaini524 – 57956SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000034086.
HOVERGENiHBG023406.
InParanoidiQ8WXK1.
KOiK10337.
OMAiGNPDCIS.
OrthoDBiEOG7WQ7S1.
PhylomeDBiQ8WXK1.
TreeFamiTF315127.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 7 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXK1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTNDDPDED HLTSYDIQLS IQESIEASKT ALCPERFVPL SAQNRKLVEA
60 70 80 90 100
IKQGHIPELQ EYVKYKYAMD EADEKGWFPL HEAVVQPIQQ ILEIVLDASY
110 120 130 140 150
KTLWEFKTCD GETPLTLAVK AGLVENVRTL LEKGVWPNTK NDKGETPLLI
160 170 180 190 200
AVKKGSYDMV STLIKHNTSL DQPCVKRWSA MHEAAKQGRK DIVALLLKHG
210 220 230 240 250
GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVLALA DDGASVLFEA
260 270 280 290 300
AGGGNPDCIS LLLEYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS
310 320 330 340 350
KNAIRKSGLT PIHSAADGQN AQCLELLIEN GFDVNTLLAD HISQSYDDER
360 370 380 390 400
KTALYFGVSN NDVHCTEVLL AAGADPNLDP LNCLLVAVRA NNYEIVRLLL
410 420 430 440 450
SHGANVNCYF MHVNDTRFPS VIQYALNDEV MLRLLLNNGY QVEMCFDCMH
460 470 480 490 500
GDIFGNSFVW SEIQEEVLPG WTSCVIKDNP FCEFITVPWM KHLVGRVTRV
510 520 530 540 550
LIDYMDYVPL CAKLKSALEV QREWPEIRQI LENPCSLKHL CRLKIRRLMG
560 570 580
LQKLCQPASV EKLPLPPAIQ RYILFKEYDL YGQELKLT
Length:588
Mass (Da):65,799
Last modified:May 18, 2010 - v3
Checksum:iB3FD2435776B343D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti346 – 3461Y → C in BAC86146. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571P → L.2 Publications
Corresponds to variant rs6962756 [ dbSNP | Ensembl ].
VAR_060466
Natural varianti357 – 3571G → A.2 Publications
Corresponds to variant rs4731112 [ dbSNP | Ensembl ].
VAR_060467

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125360 mRNA. Translation: BAC86146.1.
AC006333 Genomic DNA. No translation available.
BC100874 mRNA. Translation: AAI00875.1.
BC100875 mRNA. Translation: AAI00876.1.
BC100876 mRNA. Translation: AAI00877.1.
BC100877 mRNA. Translation: AAI00878.1.
CR749595 mRNA. Translation: CAH18393.1.
AF403033 mRNA. Translation: AAL57352.1.
CCDSiCCDS34742.1.
RefSeqiNP_001277187.1. NM_001290258.1.
NP_563616.3. NM_080928.4.
XP_005250201.1. XM_005250144.2.
XP_005250203.1. XM_005250146.2.
XP_005250204.1. XM_005250147.2.
UniGeneiHs.83916.

Genome annotation databases

EnsembliENST00000275699; ENSP00000275699; ENSG00000146809.
ENST00000434204; ENSP00000390963; ENSG00000146809.
ENST00000447789; ENSP00000401166; ENSG00000146809.
ENST00000451215; ENSP00000416433; ENSG00000146809.
ENST00000451558; ENSP00000397655; ENSG00000146809.
GeneIDi142685.
KEGGihsa:142685.
UCSCiuc003vku.1. human.

Polymorphism databases

DMDMi296439431.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125360 mRNA. Translation: BAC86146.1.
AC006333 Genomic DNA. No translation available.
BC100874 mRNA. Translation: AAI00875.1.
BC100875 mRNA. Translation: AAI00876.1.
BC100876 mRNA. Translation: AAI00877.1.
BC100877 mRNA. Translation: AAI00878.1.
CR749595 mRNA. Translation: CAH18393.1.
AF403033 mRNA. Translation: AAL57352.1.
CCDSiCCDS34742.1.
RefSeqiNP_001277187.1. NM_001290258.1.
NP_563616.3. NM_080928.4.
XP_005250201.1. XM_005250144.2.
XP_005250203.1. XM_005250146.2.
XP_005250204.1. XM_005250147.2.
UniGeneiHs.83916.

3D structure databases

ProteinModelPortaliQ8WXK1.
SMRiQ8WXK1. Positions 45-574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126774. 19 interactions.
STRINGi9606.ENSP00000275699.

PTM databases

PhosphoSiteiQ8WXK1.

Polymorphism databases

DMDMi296439431.

Proteomic databases

PaxDbiQ8WXK1.
PRIDEiQ8WXK1.

Protocols and materials databases

DNASUi142685.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275699; ENSP00000275699; ENSG00000146809.
ENST00000434204; ENSP00000390963; ENSG00000146809.
ENST00000447789; ENSP00000401166; ENSG00000146809.
ENST00000451215; ENSP00000416433; ENSG00000146809.
ENST00000451558; ENSP00000397655; ENSG00000146809.
GeneIDi142685.
KEGGihsa:142685.
UCSCiuc003vku.1. human.

Organism-specific databases

CTDi142685.
GeneCardsiGC07P123207.
H-InvDBHIX0025283.
HGNCiHGNC:19767. ASB15.
HPAiHPA028853.
neXtProtiNX_Q8WXK1.
PharmGKBiPA134977130.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000034086.
HOVERGENiHBG023406.
InParanoidiQ8WXK1.
KOiK10337.
OMAiGNPDCIS.
OrthoDBiEOG7WQ7S1.
PhylomeDBiQ8WXK1.
TreeFamiTF315127.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii142685.
NextBioi84613.
PROiQ8WXK1.

Gene expression databases

BgeeiQ8WXK1.
CleanExiHS_ASB15.
ExpressionAtlasiQ8WXK1. baseline.
GenevestigatoriQ8WXK1.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 7 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-57 AND ALA-357.
    Tissue: Tongue.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-241, VARIANT LEU-57.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 62-588, VARIANT ALA-357.
    Tissue: Liver.
  5. "SOCS box proteins."
    Kile B.T., Nicola N.A.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-588.

Entry informationi

Entry nameiASB15_HUMAN
AccessioniPrimary (citable) accession number: Q8WXK1
Secondary accession number(s): Q3ZCP3, Q3ZCP5, Q68D37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 18, 2010
Last modified: January 7, 2015
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.