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Protein

Ankyrin repeat and SOCS box protein 17

Gene

ASB17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664. Neddylation.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 17
Short name:
ASB-17
Gene namesi
Name:ASB17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000154007.6.
HGNCiHGNC:19769. ASB17.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154007.
PharmGKBiPA134958560.

Polymorphism and mutation databases

BioMutaiASB17.
DMDMi38372883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669591 – 295Ankyrin repeat and SOCS box protein 17Add BLAST295

Proteomic databases

PaxDbiQ8WXJ9.
PeptideAtlasiQ8WXJ9.
PRIDEiQ8WXJ9.

PTM databases

iPTMnetiQ8WXJ9.
PhosphoSitePlusiQ8WXJ9.

Expressioni

Gene expression databases

BgeeiENSG00000154007.
CleanExiHS_ASB17.
GenevisibleiQ8WXJ9. HS.

Interactioni

Protein-protein interaction databases

BioGridi126044. 20 interactors.
IntActiQ8WXJ9. 1 interactor.
STRINGi9606.ENSP00000284142.

Structurei

3D structure databases

ProteinModelPortaliQ8WXJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati146 – 176ANKAdd BLAST31
Domaini232 – 295SOCS boxPROSITE-ProRule annotationAdd BLAST64

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat

Phylogenomic databases

eggNOGiENOG410IHXS. Eukaryota.
ENOG4111HC1. LUCA.
GeneTreeiENSGT00390000018077.
HOGENOMiHOG000034087.
HOVERGENiHBG050587.
InParanoidiQ8WXJ9.
KOiK10339.
OMAiLLHLCRI.
OrthoDBiEOG091G0CSM.
PhylomeDBiQ8WXJ9.
TreeFamiTF337448.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
PfamiView protein in Pfam
PF07525. SOCS_box. 1 hit.
SMARTiView protein in SMART
SM00969. SOCS_box. 1 hit.
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50225. SOCS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WXJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSTKLCGK TSCPRSNIFC NLLDKIVKRP SLQFLGQWGY HCYEPRIYRS
60 70 80 90 100
LAKILRYVDL DGFDALLTDY IAFVEKSGYR FEVSFNLDFT EICVNTILYW
110 120 130 140 150
VFARKGNPDF VELLLKKTKD YVQDRSCNLA LIWRTFTPVY CPSPLSGITP
160 170 180 190 200
LFYVAQTRQS NIFKILLQYG ILEREKNPIN IVLTIVLYPS RVRVMVDREL
210 220 230 240 250
ADIHEDAKTC LVLCSRVLSV ISVKEIKTQL SLGRHPIISN WFDYIPSTRY
260 270 280 290
KDPCELLHLC RLTIRNQLLT NNMLPDGIFS LLIPARLQNY LNLEI
Length:295
Mass (Da):34,282
Last modified:November 14, 2003 - v2
Checksum:iD2F9F2C54CF2BF7F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0241742S → N. Corresponds to variant dbSNP:rs3795251Ensembl.1
Natural variantiVAR_048288101V → A. Corresponds to variant dbSNP:rs1796814Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098606 mRNA. Translation: BAC05350.1.
AF429968 mRNA. Translation: AAN85310.1.
AL445464, AC092813 Genomic DNA. Translation: CAH71811.1.
CH471059 Genomic DNA. Translation: EAX06391.1.
BC036573 mRNA. Translation: AAH36573.1.
AF403035 mRNA. Translation: AAL57354.1.
CCDSiCCDS671.1.
RefSeqiNP_543144.1. NM_080868.2.
UniGeneiHs.125423.

Genome annotation databases

EnsembliENST00000284142; ENSP00000284142; ENSG00000154007.
GeneIDi127247.
KEGGihsa:127247.
UCSCiuc001dhe.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiASB17_HUMAN
AccessioniPrimary (citable) accession number: Q8WXJ9
Secondary accession number(s): B1APB8, Q8N0X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 14, 2003
Last modified: September 27, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families