Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WXI9

- P66B_HUMAN

UniProt

Q8WXI9 - P66B_HUMAN

Protein

Transcriptional repressor p66-beta

Gene

GATAD2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri414 – 46754GATA-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ATP-dependent chromatin remodeling Source: UniProt
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_953. RNA Polymerase I Transcription Initiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional repressor p66-beta
    Alternative name(s):
    GATA zinc finger domain-containing protein 2B
    p66/p68
    Gene namesi
    Name:GATAD2B
    Synonyms:KIAA1150
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:30778. GATAD2B.

    Subcellular locationi

    Nucleus speckle 3 Publications
    Note: Speckled nuclear localization requires both CR1 and CR2 regions.

    GO - Cellular componenti

    1. nuclear chromatin Source: UniProt
    2. nuclear speck Source: UniProtKB-SubCell
    3. nucleus Source: HPA
    4. protein complex Source: UniProt

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Mental retardation, autosomal dominant 18 (MRD18) [MIM:615074]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD18 patients have severe intellectual disability and dysmorphic features.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Mental retardation

    Organism-specific databases

    MIMi615074. phenotype.
    Orphaneti363686. Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome.
    PharmGKBiPA142671747.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593Transcriptional repressor p66-betaPRO_0000083502Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei120 – 1201Phosphothreonine4 Publications
    Modified residuei122 – 1221Phosphoserine4 Publications
    Modified residuei129 – 1291Phosphoserine4 Publications
    Modified residuei134 – 1341Phosphoserine2 Publications
    Modified residuei135 – 1351Phosphoserine3 Publications
    Modified residuei333 – 3331Phosphoserine1 Publication
    Modified residuei338 – 3381Phosphoserine1 Publication
    Modified residuei486 – 4861Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WXI9.
    PaxDbiQ8WXI9.
    PeptideAtlasiQ8WXI9.
    PRIDEiQ8WXI9.

    PTM databases

    PhosphoSiteiQ8WXI9.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    BgeeiQ8WXI9.
    CleanExiHS_GATAD2B.
    GenevestigatoriQ8WXI9.

    Organism-specific databases

    HPAiHPA017015.

    Interactioni

    Subunit structurei

    Binds MBD2 and MBD3. Interaction with MBD2 is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin. Component of the MeCP1 histone deacetylase complex. Interacts with histone tails, including that of histones H2A, H2B, H3 and H4.3 Publications

    Protein-protein interaction databases

    BioGridi121529. 29 interactions.
    IntActiQ8WXI9. 21 interactions.
    MINTiMINT-1197791.
    STRINGi9606.ENSP00000357644.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXI9.
    SMRiQ8WXI9. Positions 160-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni165 – 19531CR1; MBD2- and MBD3-bindingAdd
    BLAST
    Regioni340 – 480141CR2; histone tail-bindingAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili140 – 19455Sequence AnalysisAdd
    BLAST
    Coiled coili449 – 48234Sequence AnalysisAdd
    BLAST

    Domaini

    Both CR1 and CR2 regions are required for speckled nuclear localization.

    Sequence similaritiesi

    Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri414 – 46754GATA-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG293566.
    HOGENOMiHOG000074070.
    HOVERGENiHBG053401.
    InParanoidiQ8WXI9.
    OMAiPCQRTTS.
    OrthoDBiEOG783MV0.
    PhylomeDBiQ8WXI9.
    TreeFamiTF321369.

    Family and domain databases

    Gene3Di3.30.50.10. 1 hit.
    InterProiIPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00320. GATA. 1 hit.
    [Graphical view]
    PROSITEiPS50114. GATA_ZN_FINGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WXI9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRMTEDALR LNLLKRSLDP ADERDDVLAK RLKMEGHEAM ERLKMLALLK    50
    RKDLANLEVP HELPTKQDGS GVKGYEEKLN GNLRPHGDNR TAGRPGKENI 100
    NDEPVDMSAR RSEPERGRLT PSPDIIVLSD NEASSPRSSS RMEERLKAAN 150
    LEMFKGKGIE ERQQLIKQLR DELRLEEARL VLLKKLRQSQ LQKENVVQKT 200
    PVVQNAASIV QPSPAHVGQQ GLSKLPSRPG AQGVEPQNLR TLQGHSVIRS 250
    ATNTTLPHML MSQRVIAPNP AQLQGQRGPP KPGLVRTTTP NMNPAINYQP 300
    QSSSSVPCQR TTSSAIYMNL ASHIQPGTVN RVSSPLPSPS AMTDAANSQA 350
    AAKLALRKQL EKTLLEIPPP KPPAPLLHFL PSAANSEFIY MVGLEEVVQS 400
    VIDSQGKSCA SLLRVEPFVC AQCRTDFTPH WKQEKNGKIL CEQCMTSNQK 450
    KALKAEHTNR LKNAFVKALQ QEQEIEQRLQ QQAALSPTTA PAVSSVSKQE 500
    TIMRHHTLRQ APQPQSSLQR GIPTSARSML SNFAQAPQLS VPGGLLGMPG 550
    VNIAYLNTGI GGHKGPSLAD RQREYLLDMI PPRSISQSIS GQK 593
    Length:593
    Mass (Da):65,261
    Last modified:March 1, 2002 - v1
    Checksum:i5EB375C7EB24210B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti316 – 3161I → V.1 Publication
    VAR_069363
    Natural varianti586 – 5861S → L.1 Publication
    VAR_069364

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411836 mRNA. Translation: AAL39080.1.
    AL513523 Genomic DNA. Translation: CAH71425.1.
    CH471121 Genomic DNA. Translation: EAW53270.1.
    BC069419 mRNA. Translation: AAH69419.1.
    BC112052 mRNA. Translation: AAI12053.1.
    BC112080 mRNA. Translation: AAI12081.1.
    AB032976 mRNA. Translation: BAA86464.1.
    CCDSiCCDS1054.1.
    RefSeqiNP_065750.1. NM_020699.2.
    XP_005245421.1. XM_005245364.2.
    XP_006711532.1. XM_006711469.1.
    UniGeneiHs.4779.
    Hs.596854.

    Genome annotation databases

    EnsembliENST00000368655; ENSP00000357644; ENSG00000143614.
    ENST00000576342; ENSP00000458280; ENSG00000261992.
    GeneIDi57459.
    KEGGihsa:57459.
    UCSCiuc001fdb.4. human.

    Polymorphism databases

    DMDMi50401096.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411836 mRNA. Translation: AAL39080.1 .
    AL513523 Genomic DNA. Translation: CAH71425.1 .
    CH471121 Genomic DNA. Translation: EAW53270.1 .
    BC069419 mRNA. Translation: AAH69419.1 .
    BC112052 mRNA. Translation: AAI12053.1 .
    BC112080 mRNA. Translation: AAI12081.1 .
    AB032976 mRNA. Translation: BAA86464.1 .
    CCDSi CCDS1054.1.
    RefSeqi NP_065750.1. NM_020699.2.
    XP_005245421.1. XM_005245364.2.
    XP_006711532.1. XM_006711469.1.
    UniGenei Hs.4779.
    Hs.596854.

    3D structure databases

    ProteinModelPortali Q8WXI9.
    SMRi Q8WXI9. Positions 160-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121529. 29 interactions.
    IntActi Q8WXI9. 21 interactions.
    MINTi MINT-1197791.
    STRINGi 9606.ENSP00000357644.

    PTM databases

    PhosphoSitei Q8WXI9.

    Polymorphism databases

    DMDMi 50401096.

    Proteomic databases

    MaxQBi Q8WXI9.
    PaxDbi Q8WXI9.
    PeptideAtlasi Q8WXI9.
    PRIDEi Q8WXI9.

    Protocols and materials databases

    DNASUi 57459.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368655 ; ENSP00000357644 ; ENSG00000143614 .
    ENST00000576342 ; ENSP00000458280 ; ENSG00000261992 .
    GeneIDi 57459.
    KEGGi hsa:57459.
    UCSCi uc001fdb.4. human.

    Organism-specific databases

    CTDi 57459.
    GeneCardsi GC01M153777.
    HGNCi HGNC:30778. GATAD2B.
    HPAi HPA017015.
    MIMi 614998. gene.
    615074. phenotype.
    neXtProti NX_Q8WXI9.
    Orphaneti 363686. Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome.
    PharmGKBi PA142671747.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293566.
    HOGENOMi HOG000074070.
    HOVERGENi HBG053401.
    InParanoidi Q8WXI9.
    OMAi PCQRTTS.
    OrthoDBi EOG783MV0.
    PhylomeDBi Q8WXI9.
    TreeFami TF321369.

    Enzyme and pathway databases

    Reactomei REACT_953. RNA Polymerase I Transcription Initiation.

    Miscellaneous databases

    ChiTaRSi GATAD2B. human.
    GeneWikii GATAD2B.
    GenomeRNAii 57459.
    NextBioi 63644.
    PROi Q8WXI9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WXI9.
    CleanExi HS_GATAD2B.
    Genevestigatori Q8WXI9.

    Family and domain databases

    Gene3Di 3.30.50.10. 1 hit.
    InterProi IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00320. GATA. 1 hit.
    [Graphical view ]
    PROSITEi PS50114. GATA_ZN_FINGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and functional characterization of the p66/p68 components of the MeCP1 complex."
      Feng Q., Cao R., Xia L., Erdjument-Bromage H., Tempst P., Zhang Y.
      Mol. Cell. Biol. 22:536-546(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH MBD2; MBD3 AND THE MECP1 COMPLEX, SUBCELLULAR LOCATION.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-593.
      Tissue: Brain.
    6. "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3."
      Brackertz M., Boeke J., Zhang R., Renkawitz R.
      J. Biol. Chem. 277:40958-40966(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MBD2 AND MBD3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-486, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction."
      Brackertz M., Gong Z., Leers J., Renkawitz R.
      Nucleic Acids Res. 34:397-406(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MBD2 AND HISTONE TAILS, SUBCELLULAR LOCATION.
    9. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
      J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-120; SER-122; SER-129; SER-134; SER-135; SER-333 AND SER-486, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-120; SER-122; SER-129; SER-134 AND SER-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-120; SER-122; SER-129; SER-135; SER-338 AND SER-486, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-120; SER-122 AND SER-129, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila."
      Willemsen M.H., Nijhof B., Fenckova M., Nillesen W.M., Bongers E.M., Castells-Nobau A., Asztalos L., Viragh E., van Bon B.W., Tezel E., Veltman J.A., Brunner H.G., de Vries B.B., de Ligt J., Yntema H.G., van Bokhoven H., Isidor B., Le Caignec C.
      , Lorino E., Asztalos Z., Koolen D.A., Vissers L.E., Schenck A., Kleefstra T.
      J. Med. Genet. 50:507-514(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN MRD18.
    18. Cited for: INVOLVEMENT IN MRD18, VARIANTS VAL-316 AND LEU-586.

    Entry informationi

    Entry nameiP66B_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXI9
    Secondary accession number(s): D3DUZ2
    , Q5VUR2, Q7LG68, Q9ULS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3