Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional repressor p66-beta

Gene

GATAD2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri414 – 467GATA-typePROSITE-ProRule annotationAdd BLAST54

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor p66-beta
Alternative name(s):
GATA zinc finger domain-containing protein 2B
p66/p68
Gene namesi
Name:GATAD2B
Synonyms:KIAA1150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143614.8
HGNCiHGNC:30778 GATAD2B
MIMi614998 gene
neXtProtiNX_Q8WXI9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal dominant 18 (MRD18)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD18 patients have severe intellectual disability and dysmorphic features.
See also OMIM:615074

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNETi57459
MalaCardsiGATAD2B
MIMi615074 phenotype
OpenTargetsiENSG00000143614
Orphaneti363686 Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome
PharmGKBiPA142671747

Polymorphism and mutation databases

BioMutaiGATAD2B
DMDMi50401096

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835021 – 593Transcriptional repressor p66-betaAdd BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei120PhosphothreonineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei208PhosphoserineCombined sources1
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei333PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei340PhosphoserineBy similarity1
Cross-linki353Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki454Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei486PhosphoserineCombined sources1
Cross-linki498Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WXI9
MaxQBiQ8WXI9
PaxDbiQ8WXI9
PeptideAtlasiQ8WXI9
PRIDEiQ8WXI9

PTM databases

iPTMnetiQ8WXI9
PhosphoSitePlusiQ8WXI9

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000143614
CleanExiHS_GATAD2B
ExpressionAtlasiQ8WXI9 baseline and differential
GenevisibleiQ8WXI9 HS

Organism-specific databases

HPAiHPA017015

Interactioni

Subunit structurei

Binds MBD2 and MBD3. Interaction with MBD2 is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin. Component of the MeCP1 histone deacetylase complex. Interacts with histone tails, including that of histones H2A, H2B, H3 and H4.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121529, 91 interactors
CORUMiQ8WXI9
DIPiDIP-36054N
IntActiQ8WXI9, 68 interactors
MINTiQ8WXI9
STRINGi9606.ENSP00000357644

Structurei

3D structure databases

ProteinModelPortaliQ8WXI9
SMRiQ8WXI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 195CR1; MBD2- and MBD3-bindingAdd BLAST31
Regioni340 – 480CR2; histone tail-bindingAdd BLAST141

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili140 – 194Sequence analysisAdd BLAST55
Coiled coili449 – 482Sequence analysisAdd BLAST34

Domaini

Both CR1 and CR2 regions are required for speckled nuclear localization.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri414 – 467GATA-typePROSITE-ProRule annotationAdd BLAST54

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ4W Eukaryota
ENOG410ZCNE LUCA
GeneTreeiENSGT00390000004097
HOGENOMiHOG000074070
HOVERGENiHBG053401
InParanoidiQ8WXI9
OMAiMNPTINY
OrthoDBiEOG091G0HRN
PhylomeDBiQ8WXI9
TreeFamiTF321369

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR032346 P66_CC
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00320 GATA, 1 hit
PF16563 P66_CC, 1 hit
PROSITEiView protein in PROSITE
PS50114 GATA_ZN_FINGER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WXI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRMTEDALR LNLLKRSLDP ADERDDVLAK RLKMEGHEAM ERLKMLALLK
60 70 80 90 100
RKDLANLEVP HELPTKQDGS GVKGYEEKLN GNLRPHGDNR TAGRPGKENI
110 120 130 140 150
NDEPVDMSAR RSEPERGRLT PSPDIIVLSD NEASSPRSSS RMEERLKAAN
160 170 180 190 200
LEMFKGKGIE ERQQLIKQLR DELRLEEARL VLLKKLRQSQ LQKENVVQKT
210 220 230 240 250
PVVQNAASIV QPSPAHVGQQ GLSKLPSRPG AQGVEPQNLR TLQGHSVIRS
260 270 280 290 300
ATNTTLPHML MSQRVIAPNP AQLQGQRGPP KPGLVRTTTP NMNPAINYQP
310 320 330 340 350
QSSSSVPCQR TTSSAIYMNL ASHIQPGTVN RVSSPLPSPS AMTDAANSQA
360 370 380 390 400
AAKLALRKQL EKTLLEIPPP KPPAPLLHFL PSAANSEFIY MVGLEEVVQS
410 420 430 440 450
VIDSQGKSCA SLLRVEPFVC AQCRTDFTPH WKQEKNGKIL CEQCMTSNQK
460 470 480 490 500
KALKAEHTNR LKNAFVKALQ QEQEIEQRLQ QQAALSPTTA PAVSSVSKQE
510 520 530 540 550
TIMRHHTLRQ APQPQSSLQR GIPTSARSML SNFAQAPQLS VPGGLLGMPG
560 570 580 590
VNIAYLNTGI GGHKGPSLAD RQREYLLDMI PPRSISQSIS GQK
Length:593
Mass (Da):65,261
Last modified:March 1, 2002 - v1
Checksum:i5EB375C7EB24210B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069363316I → V1 Publication1
Natural variantiVAR_069364586S → L1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411836 mRNA Translation: AAL39080.1
AL513523 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53270.1
BC069419 mRNA Translation: AAH69419.1
BC112052 mRNA Translation: AAI12053.1
BC112080 mRNA Translation: AAI12081.1
AB032976 mRNA Translation: BAA86464.1
CCDSiCCDS1054.1
RefSeqiNP_065750.1, NM_020699.3
XP_005245421.1, XM_005245364.4
UniGeneiHs.4779
Hs.596854

Genome annotation databases

EnsembliENST00000368655; ENSP00000357644; ENSG00000143614
ENST00000576342; ENSP00000458280; ENSG00000261992
ENST00000634544; ENSP00000489184; ENSG00000143614
GeneIDi57459
KEGGihsa:57459
UCSCiuc001fdb.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP66B_HUMAN
AccessioniPrimary (citable) accession number: Q8WXI9
Secondary accession number(s): D3DUZ2
, Q5VUR2, Q7LG68, Q9ULS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health