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Q8WXI7

- MUC16_HUMAN

UniProt

Q8WXI7 - MUC16_HUMAN

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Protein

Mucin-16

Gene

MUC16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. cellular protein metabolic process Source: Reactome
  3. O-glycan processing Source: Reactome
  4. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-16
Short name:
MUC-16
Alternative name(s):
Ovarian cancer-related tumor marker CA125
Short name:
CA-125
Ovarian carcinoma antigen CA125
Gene namesi
Name:MUC16
Synonyms:CA125
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:15582. MUC16.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Secretedextracellular space
Note: May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. extrinsic component of membrane Source: UniProtKB
  3. Golgi lumen Source: Reactome
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: UniProtKB-KW
  6. vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2215222152Mucin-16PRO_0000259595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi787 – 7871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi930 – 9301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1375 – 13751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1633 – 16331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1840 – 18401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1877 – 18771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1890 – 18901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2345 – 23451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2375 – 23751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2737 – 27371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3086 – 30861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3179 – 31791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3502 – 35021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4222 – 42221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4500 – 45001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4608 – 46081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4615 – 46151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4626 – 46261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4863 – 48631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5098 – 50981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5133 – 51331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5230 – 52301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5322 – 53221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5396 – 53961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5472 – 54721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5691 – 56911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5865 – 58651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi6090 – 60901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi6734 – 67341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi6861 – 68611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi6963 – 69631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi8031 – 80311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi8057 – 80571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi8326 – 83261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi8620 – 86201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi8686 – 86861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi8915 – 89151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9204 – 92041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9495 – 94951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9787 – 97871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9920 – 99201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10077 – 100771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10175 – 101751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10512 – 105121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10702 – 107021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10751 – 107511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11055 – 110551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11226 – 112261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11265 – 112651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11369 – 113691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11596 – 115961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12081 – 120811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12102 – 121021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12118 – 121181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi12128 ↔ 12148Sequence Analysis
Glycosylationi12170 – 121701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12237 – 122371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12274 – 122741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi12284 ↔ 12304Sequence Analysis
Glycosylationi12395 – 123951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12416 – 124161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12432 – 124321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi12442 ↔ 12462Sequence Analysis
Glycosylationi12551 – 125511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12572 – 125721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12588 – 125881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi12598 ↔ 12618Sequence Analysis
Glycosylationi12706 – 127061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12727 – 127271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12743 – 127431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi12753 ↔ 12773Sequence Analysis
Glycosylationi12826 – 128261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12862 – 128621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12883 – 128831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi12909 ↔ 12929Sequence Analysis
Glycosylationi12982 – 129821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13018 – 130181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13039 – 130391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13055 – 130551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi13065 ↔ 13085Sequence Analysis
Glycosylationi13174 – 131741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13195 – 131951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13211 – 132111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi13221 ↔ 13241Sequence Analysis
Glycosylationi13330 – 133301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13351 – 133511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13367 – 133671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi13377 ↔ 13397Sequence Analysis
Glycosylationi13423 – 134231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13486 – 134861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13507 – 135071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13523 – 135231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi13533 ↔ 13553Sequence Analysis
Glycosylationi13579 – 135791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13642 – 136421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13663 – 136631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13679 – 136791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi13689 ↔ 13709Sequence Analysis
Glycosylationi13798 – 137981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13819 – 138191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13835 – 138351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi13845 ↔ 13865Sequence Analysis
Glycosylationi13954 – 139541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13975 – 139751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13991 – 139911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi14001 ↔ 14021Sequence Analysis
Glycosylationi14110 – 141101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14131 – 141311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14147 – 141471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi14157 ↔ 14177Sequence Analysis
Glycosylationi14266 – 142661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14287 – 142871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14303 – 143031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi14313 ↔ 14333Sequence Analysis
Glycosylationi14359 – 143591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14422 – 144221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14459 – 144591N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi14469 ↔ 14489Sequence Analysis
Glycosylationi14580 – 145801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14601 – 146011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14617 – 146171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi14627 ↔ 14647Sequence Analysis
Glycosylationi14736 – 147361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14757 – 147571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14773 – 147731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi14783 ↔ 14803Sequence Analysis
Glycosylationi14825 – 148251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14892 – 148921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14913 – 149131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14929 – 149291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi14939 ↔ 14959Sequence Analysis
Glycosylationi15048 – 150481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15069 – 150691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi15095 ↔ 15115Sequence Analysis
Glycosylationi15204 – 152041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15241 – 152411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi15251 ↔ 15271Sequence Analysis
Glycosylationi15360 – 153601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15381 – 153811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15397 – 153971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi15407 ↔ 15427Sequence Analysis
Glycosylationi15516 – 155161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15537 – 155371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi15563 ↔ 15583Sequence Analysis
Glycosylationi15672 – 156721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15693 – 156931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15709 – 157091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi15719 ↔ 15739Sequence Analysis
Glycosylationi15827 – 158271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15848 – 158481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15864 – 158641N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi15874 ↔ 15894Sequence Analysis
Glycosylationi15947 – 159471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15983 – 159831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16004 – 160041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16020 – 160201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16138 – 161381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16159 – 161591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16175 – 161751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi16185 ↔ 16205Sequence Analysis
Glycosylationi16258 – 162581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16294 – 162941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16315 – 163151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16331 – 163311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi16341 ↔ 16361Sequence Analysis
Glycosylationi16450 – 164501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16471 – 164711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16487 – 164871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi16497 ↔ 16517Sequence Analysis
Glycosylationi16539 – 165391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16606 – 166061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16627 – 166271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16643 – 166431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi16653 ↔ 16673Sequence Analysis
Glycosylationi16762 – 167621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16783 – 167831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16799 – 167991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi16809 ↔ 16829Sequence Analysis
Glycosylationi16918 – 169181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16939 – 169391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16955 – 169551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi16965 ↔ 16985Sequence Analysis
Glycosylationi17074 – 170741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17095 – 170951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17111 – 171111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi17121 ↔ 17141Sequence Analysis
Glycosylationi17230 – 172301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17251 – 172511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi17277 ↔ 17297Sequence Analysis
Glycosylationi17386 – 173861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17407 – 174071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17423 – 174231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi17433 ↔ 17453Sequence Analysis
Glycosylationi17542 – 175421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17563 – 175631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17579 – 175791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi17589 ↔ 17609Sequence Analysis
Glycosylationi17698 – 176981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17719 – 177191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi17745 ↔ 17765Sequence Analysis
Glycosylationi17854 – 178541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17875 – 178751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17891 – 178911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18010 – 180101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18031 – 180311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18047 – 180471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi18057 ↔ 18077Sequence Analysis
Glycosylationi18166 – 181661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18187 – 181871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18203 – 182031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18322 – 183221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18343 – 183431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18359 – 183591N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi18369 ↔ 18389Sequence Analysis
Glycosylationi18478 – 184781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18499 – 184991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18515 – 185151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18634 – 186341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18655 – 186551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi18681 ↔ 18701Sequence Analysis
Glycosylationi18790 – 187901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18811 – 188111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18827 – 188271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18946 – 189461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18967 – 189671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18983 – 189831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi18993 ↔ 19013Sequence Analysis
Glycosylationi19039 – 190391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19102 – 191021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19123 – 191231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19139 – 191391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19258 – 192581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19279 – 192791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19295 – 192951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi19305 ↔ 19325Sequence Analysis
Glycosylationi19414 – 194141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19435 – 194351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19451 – 194511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19570 – 195701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19591 – 195911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19607 – 196071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi19617 ↔ 19637Sequence Analysis
Glycosylationi19726 – 197261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19747 – 197471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19763 – 197631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19881 – 198811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19902 – 199021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19918 – 199181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi19928 ↔ 19948Sequence Analysis
Glycosylationi20037 – 200371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20058 – 200581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20074 – 200741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20157 – 201571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20193 – 201931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20214 – 202141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20230 – 202301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20349 – 203491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20370 – 203701N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi20396 ↔ 20416Sequence Analysis
Glycosylationi20505 – 205051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20526 – 205261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi20552 ↔ 20572Sequence Analysis
Glycosylationi20661 – 206611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20682 – 206821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20698 – 206981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi20708 ↔ 20728Sequence Analysis
Glycosylationi20817 – 208171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20838 – 208381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi20864 ↔ 20884Sequence Analysis
Glycosylationi20973 – 209731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi20994 – 209941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21010 – 210101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi21020 ↔ 21040Sequence Analysis
Glycosylationi21129 – 211291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21150 – 211501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21166 – 211661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi21176 ↔ 21196Sequence Analysis
Glycosylationi21285 – 212851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21306 – 213061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi21332 ↔ 21352Sequence Analysis
Glycosylationi21378 – 213781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21389 – 213891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21441 – 214411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21461 – 214611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21477 – 214771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21574 – 215741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21595 – 215951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi21621 ↔ 21641Sequence Analysis
Glycosylationi21725 – 217251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21745 – 217451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi21771 ↔ 21791Sequence Analysis
Glycosylationi21840 – 218401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21857 – 218571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21899 – 218991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21932 – 219321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21971 – 219711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi22008 – 220081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi22018 ↔ 22038Sequence Analysis
Glycosylationi22062 – 220621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi22068 – 220681N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.1 Publication
Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.1 Publication
May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.1 Publication
May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8WXI7.
PaxDbiQ8WXI7.
PRIDEiQ8WXI7.

PTM databases

PhosphoSiteiQ8WXI7.

Expressioni

Tissue specificityi

Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.3 Publications

Inductioni

Up-regulated in ovarian cancer cells.1 Publication

Gene expression databases

CleanExiHS_MUC16.
GenevestigatoriQ8WXI7.

Organism-specific databases

HPAiCAB055172.

Interactioni

Subunit structurei

Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.

Protein-protein interaction databases

BioGridi125094. 3 interactions.
STRINGi9606.ENSP00000381008.

Structurei

3D structure databases

ProteinModelPortaliQ8WXI7.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2209622096ExtracellularSequence AnalysisAdd
BLAST
Topological domaini22118 – 2215235CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22097 – 2211721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12070 – 12190121SEA 1PROSITE-ProRule annotationAdd
BLAST
Domaini12229 – 12339111SEA 2PROSITE-ProRule annotationAdd
BLAST
Domaini12386 – 12504119SEA 3PROSITE-ProRule annotationAdd
BLAST
Domaini12539 – 12660122SEA 4PROSITE-ProRule annotationAdd
BLAST
Domaini12697 – 12815119SEA 5PROSITE-ProRule annotationAdd
BLAST
Domaini12853 – 12971119SEA 6PROSITE-ProRule annotationAdd
BLAST
Domaini13009 – 13127119SEA 7PROSITE-ProRule annotationAdd
BLAST
Domaini13165 – 13283119SEA 8PROSITE-ProRule annotationAdd
BLAST
Domaini13315 – 13439125SEA 9PROSITE-ProRule annotationAdd
BLAST
Domaini13477 – 13595119SEA 10PROSITE-ProRule annotationAdd
BLAST
Domaini13633 – 13751119SEA 11PROSITE-ProRule annotationAdd
BLAST
Repeati13767 – 1380135ANK 1Add
BLAST
Domaini13789 – 13907119SEA 12PROSITE-ProRule annotationAdd
BLAST
Domaini13939 – 14063125SEA 13PROSITE-ProRule annotationAdd
BLAST
Domaini14101 – 14219119SEA 14PROSITE-ProRule annotationAdd
BLAST
Domaini14251 – 14375125SEA 15PROSITE-ProRule annotationAdd
BLAST
Domaini14410 – 14531122SEA 16PROSITE-ProRule annotationAdd
BLAST
Domaini14567 – 14689123SEA 17PROSITE-ProRule annotationAdd
BLAST
Domaini14723 – 14845123SEA 18PROSITE-ProRule annotationAdd
BLAST
Domaini14877 – 15001125SEA 19PROSITE-ProRule annotationAdd
BLAST
Domaini15039 – 15157119SEA 20PROSITE-ProRule annotationAdd
BLAST
Domaini15195 – 15313119SEA 21PROSITE-ProRule annotationAdd
BLAST
Domaini15348 – 15469122SEA 22PROSITE-ProRule annotationAdd
BLAST
Domaini15507 – 15625119SEA 23PROSITE-ProRule annotationAdd
BLAST
Domaini15664 – 15774111SEA 24PROSITE-ProRule annotationAdd
BLAST
Domaini15812 – 15936125SEA 25PROSITE-ProRule annotationAdd
BLAST
Domaini16123 – 16247125SEA 26PROSITE-ProRule annotationAdd
BLAST
Domaini16279 – 16403125SEA 27PROSITE-ProRule annotationAdd
BLAST
Domaini16437 – 16559123SEA 28PROSITE-ProRule annotationAdd
BLAST
Domaini16591 – 16715125SEA 29PROSITE-ProRule annotationAdd
BLAST
Domaini16750 – 16871122SEA 30PROSITE-ProRule annotationAdd
BLAST
Domaini16905 – 17027123SEA 31PROSITE-ProRule annotationAdd
BLAST
Domaini17065 – 17183119SEA 32PROSITE-ProRule annotationAdd
BLAST
Domaini17221 – 17339119SEA 33PROSITE-ProRule annotationAdd
BLAST
Domaini17378 – 17488111SEA 34PROSITE-ProRule annotationAdd
BLAST
Domaini17534 – 17644111SEA 35PROSITE-ProRule annotationAdd
BLAST
Domaini17689 – 17807119SEA 36PROSITE-ProRule annotationAdd
BLAST
Domaini18001 – 18119119SEA 37PROSITE-ProRule annotationAdd
BLAST
Domaini18313 – 18431119SEA 38PROSITE-ProRule annotationAdd
BLAST
Domaini18625 – 18743119SEA 39PROSITE-ProRule annotationAdd
BLAST
Repeati18915 – 1894935ANK 2Add
BLAST
Domaini18937 – 19055119SEA 40PROSITE-ProRule annotationAdd
BLAST
Domaini19243 – 19367125SEA 41PROSITE-ProRule annotationAdd
BLAST
Domaini19555 – 19679125SEA 42PROSITE-ProRule annotationAdd
BLAST
Domaini19866 – 19990125SEA 43PROSITE-ProRule annotationAdd
BLAST
Domaini20184 – 20302119SEA 44PROSITE-ProRule annotationAdd
BLAST
Domaini20340 – 20458119SEA 45PROSITE-ProRule annotationAdd
BLAST
Domaini20496 – 20614119SEA 46PROSITE-ProRule annotationAdd
BLAST
Domaini20652 – 20770119SEA 47PROSITE-ProRule annotationAdd
BLAST
Domaini20804 – 20926123SEA 48PROSITE-ProRule annotationAdd
BLAST
Domaini20964 – 21082119SEA 49PROSITE-ProRule annotationAdd
BLAST
Domaini21117 – 21238122SEA 50PROSITE-ProRule annotationAdd
BLAST
Domaini21273 – 21394122SEA 51PROSITE-ProRule annotationAdd
BLAST
Domaini21433 – 21542110SEA 52PROSITE-ProRule annotationAdd
BLAST
Domaini21565 – 21683119SEA 53PROSITE-ProRule annotationAdd
BLAST
Domaini21717 – 21826110SEA 54PROSITE-ProRule annotationAdd
BLAST
Domaini21836 – 21957122SEA 55PROSITE-ProRule annotationAdd
BLAST
Domaini21959 – 22080122SEA 56PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 1208512072Thr-richAdd
BLAST
Compositional biasi1638 – 30551418Ser-richAdd
BLAST
Compositional biasi3961 – 4385425Ser-richAdd
BLAST
Compositional biasi7085 – 103953311Ser-richAdd
BLAST

Domaini

Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.

Sequence similaritiesi

Contains 2 ANK repeats.Curated
Contains 56 SEA domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
KOiK16145.

Family and domain databases

Gene3Di3.30.70.960. 65 hits.
InterProiIPR028850. MUC16.
IPR000082. SEA_dom.
[Graphical view]
PANTHERiPTHR14672. PTHR14672. 1 hit.
PfamiPF01390. SEA. 55 hits.
[Graphical view]
SMARTiSM00200. SEA. 23 hits.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 65 hits.
PROSITEiPS50024. SEA. 65 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXI7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MLKPSGLPGS SSPTRSLMTG SRSTKATPEM DSGLTGATLS PKTSTGAIVV
60 70 80 90 100
TEHTLPFTSP DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR
110 120 130 140 150
TSPSLSPQVN GTPSRNYPAT SMVSGLSSPR TRTSSTEGNF TKEASTYTLT
160 170 180 190 200
VETTSGPVTE KYTVPTETST TEGDSTETPW DTRYIPVKIT SPMKTFADST
210 220 230 240 250
ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL SPKGTPNSRG
260 270 280 290 300
ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI
310 320 330 340 350
FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL
360 370 380 390 400
GTPSISTKQT AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS
410 420 430 440 450
TSALTTTSPS TTLVSEETNT HHSTSGKETE GTLNTSMTPL ETSAPGEESE
460 470 480 490 500
MTATLVPTLG FTTLDSKIRS PSQVSSSHPT RELRTTGSTS GRQSSSTAAH
510 520 530 540 550
GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS PSMKTERPPA
560 570 580 590 600
STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT
610 620 630 640 650
HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS
660 670 680 690 700
VSPAVSKTAA GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP
710 720 730 740 750
LNTRHPFSSP EPDSAGHTKI STSIPLLSSA SVLEDKVSAT STFSHHKATS
760 770 780 790 800
SITTGTPEIS TKTKPSSAVL SSMTLSNAAT SPERVRNATS PLTHPSPSGE
810 820 830 840 850
ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL PSVSGVKTTF
860 870 880 890 900
SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT
910 920 930 940 950
MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ
960 970 980 990 1000
TNRDTFNDSA APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK
1010 1020 1030 1040 1050
FTSPATSSME ATSIREPSTT ILTTETTNGP GSMAVASTNI PIGKGYITEG
1060 1070 1080 1090 1100
RLDTSHLPIG TTASSETSMD FTMAKESVSM SVSPSQSMDA AGSSTPGRTS
1110 1120 1130 1140 1150
QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS PDPGSARSTW
1160 1170 1180 1190 1200
LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS
1210 1220 1230 1240 1250
LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS
1260 1270 1280 1290 1300
IHLGAHASSE SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS
1310 1320 1330 1340 1350
SGSSPEMTAP GETNTGSTWD PTTYITTTDP KDTSSAQVST PHSVRTLRTT
1360 1370 1380 1390 1400
ENHPKTESAT PAAYSGSPKI SSSPNLTSPA TKAWTITDTT EHSTQLHYTK
1410 1420 1430 1440 1450
LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG EPLVLAPSEQ
1460 1470 1480 1490 1500
TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS
1510 1520 1530 1540 1550
KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH
1560 1570 1580 1590 1600
STQAQDTLSA TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS
1610 1620 1630 1640 1650
SEATTFWKPS TDTLSREIET GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL
1660 1670 1680 1690 1700
PIGTSSPAET STNMALERRS STATVSMAGT MGLLVTSAPG RSISQSLGRV
1710 1720 1730 1740 1750
SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA EGSQMSTSIP
1760 1770 1780 1790 1800
LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL
1810 1820 1830 1840 1850
GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG
1860 1870 1880 1890 1900
VHTSSAGTLA TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTDTE
1910 1920 1930 1940 1950
KSEVSSSIHP RPETSAPGAE TTLTSTPGNR AISLTLPFSS IPVEEVISTG
1960 1970 1980 1990 2000
ITSGPDINSA PMTHSPITPP TIVWTSTGTI EQSTQPLHAV SSEKVSVQTQ
2010 2020 2030 2040 2050
STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS TISRRNAITS
2060 2070 2080 2090 2100
WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA
2110 2120 2130 2140 2150
AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI
2160 2170 2180 2190 2200
TSRSDVSGLT SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP
2210 2220 2230 2240 2250
WTVSIPLGSH PTTNTETSIP VNSAGPPGLS TVASDVIDTP SDGAESIPTV
2260 2270 2280 2290 2300
SFSPSPDTEV TTISHFPEKT THSFRTISSL THELTSRVTP IPGDWMSSAM
2310 2320 2330 2340 2350
STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST VSLDNETTVK
2360 2370 2380 2390 2400
TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT
2410 2420 2430 2440 2450
ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL
2460 2470 2480 2490 2500
PPFTITHPVE TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP
2510 2520 2530 2540 2550
APGTWASVGS TTDLPAMGFL KTSPAGEAHS LLASTIEPAT AFTPHLSAAV
2560 2570 2580 2590 2600
VTGSSATSEA SLLTTSESKA IHSSPQTPTT PTSGANWETS ATPESLLVVT
2610 2620 2630 2640 2650
ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF PTLLPDTPAI
2660 2670 2680 2690 2700
PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK
2710 2720 2730 2740 2750
TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST
2760 2770 2780 2790 2800
LPAGTTGSLV FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG
2810 2820 2830 2840 2850
IRSGSTHSTG TKTFSSLPLT MNPGEVTAMS EITTNRLTAT QSTAPKGIPV
2860 2870 2880 2890 2900
KPTSAESGLL TPVSASSSPS KAFASLTTAP PSTWGIPQST LTFEFSEVPS
2910 2920 2930 2940 2950
LDTKSASLPT PGQSLNTIPD SDASTASSSL SKSPEKNPRA RMMTSTKAIS
2960 2970 2980 2990 3000
ASSFQSTGFT ETPEGSASPS MAGHEPRVPT SGTGDPRYAS ESMSYPDPSK
3010 3020 3030 3040 3050
ASSAMTSTSL ASKLTTLFST GQAARSGSSS SPISLSTEKE TSFLSPTAST
3060 3070 3080 3090 3100
SRKTSLFLGP SMARQPNILV HLQTSALTLS PTSTLNMSQE EPPELTSSQT
3110 3120 3130 3140 3150
IAEEEGTTAE TQTLTFTPSE TPTSLLPVSS PTEPTARRKS SPETWASSIS
3160 3170 3180 3190 3200
VPAKTSLVET TDGTLVTTIK MSSQAAQGNS TWPAPAEETG TSPAGTSPGS
3210 3220 3230 3240 3250
PEVSTTLKIM SSKEPSISPE IRSTVRNSPW KTPETTVPME TTVEPVTLQS
3260 3270 3280 3290 3300
TALGSGSTSI SHLPTGTTSP TKSPTENMLA TERVSLSPSP PEAWTNLYSG
3310 3320 3330 3340 3350
TPGGTRQSLA TMSSVSLESP TARSITGTGQ QSSPELVSKT TGMEFSMWHG
3360 3370 3380 3390 3400
STGGTTGDTH VSLSTSSNIL EDPVTSPNSV SSLTDKSKHK TETWVSTTAI
3410 3420 3430 3440 3450
PSTVLNNKIM AAEQQTSRSV DEAYSSTSSW SDQTSGSDIT LGASPDVTNT
3460 3470 3480 3490 3500
LYITSTAQTT SLVSLPSGDQ GITSLTNPSG GKTSSASSVT SPSIGLETLR
3510 3520 3530 3540 3550
ANVSAVKSDI APTAGHLSQT SSPAEVSILD VTTAPTPGIS TTITTMGTNS
3560 3570 3580 3590 3600
ISTTTPNPEV GMSTMDSTPA TERRTTSTEH PSTWSSTAAS DSWTVTDMTS
3610 3620 3630 3640 3650
NLKVARSPGT ISTMHTTSFL ASSTELDSMS TPHGRITVIG TSLVTPSSDA
3660 3670 3680 3690 3700
SAVKTETSTS ERTLSPSDTT ASTPISTFSR VQRMSISVPD ILSTSWTPSS
3710 3720 3730 3740 3750
TEAEDVPVSM VSTDHASTKT DPNTPLSTFL FDSLSTLDWD TGRSLSSATA
3760 3770 3780 3790 3800
TTSAPQGATT PQELTLETMI SPATSQLPFS IGHITSAVTP AAMARSSGVT
3810 3820 3830 3840 3850
FSRPDPTSKK AEQTSTQLPT TTSAHPGQVP RSAATTLDVI PHTAKTPDAT
3860 3870 3880 3890 3900
FQRQGQTALT TEARATSDSW NEKEKSTPSA PWITEMMNSV SEDTIKEVTS
3910 3920 3930 3940 3950
SSSVLKDPEY AGHKLGIWDD FIPKFGKAAH MRELPLLSPP QDKEAIHPST
3960 3970 3980 3990 4000
NTVETTGWVT SSEHASHSTI PAHSASSKLT SPVVTTSTRE QAIVSMSTTT
4010 4020 4030 4040 4050
WPESTRARTE PNSFLTIELR DVSPYMDTSS TTQTSIISSP GSTAITKGPR
4060 4070 4080 4090 4100
TEITSSKRIS SSFLAQSMRS SDSPSEAITR LSNFPAMTES GGMILAMQTS
4110 4120 4130 4140 4150
PPGATSLSAP TLDTSATASW TGTPLATTQR FTYSEKTTLF SKGPEDTSQP
4160 4170 4180 4190 4200
SPPSVEETSS SSSLVPIHAT TSPSNILLTS QGHSPSSTPP VTSVFLSETS
4210 4220 4230 4240 4250
GLGKTTDMSR ISLEPGTSLP PNLSSTAGEA LSTYEASRDT KAIHHSADTA
4260 4270 4280 4290 4300
VTNMEATSSE YSPIPGHTKP SKATSPLVTS HIMGDITSST SVFGSSETTE
4310 4320 4330 4340 4350
IETVSSVNQG LQERSTSQVA SSATETSTVI THVSSGDATT HVTKTQATFS
4360 4370 4380 4390 4400
SGTSISSPHQ FITSTNTFTD VSTNPSTSLI MTESSGVTIT TQTGPTGAAT
4410 4420 4430 4440 4450
QGPYLLDTST MPYLTETPLA VTPDFMQSEK TTLISKGPKD VTWTSPPSVA
4460 4470 4480 4490 4500
ETSYPSSLTP FLVTTIPPAT STLQGQHTSS PVSATSVLTS GLVKTTDMLN
4510 4520 4530 4540 4550
TSMEPVTNSP QNLNNPSNEI LATLAATTDI ETIHPSINKA VTNMGTASSA
4560 4570 4580 4590 4600
HVLHSTLPVS SEPSTATSPM VPASSMGDAL ASISIPGSET TDIEGEPTSS
4610 4620 4630 4640 4650
LTAGRKENST LQEMNSTTES NIILSNVSVG AITEATKMEV PSFDATFIPT
4660 4670 4680 4690 4700
PAQSTKFPDI FSVASSRLSN SPPMTISTHM TTTQTGSSGA TSKIPLALDT
4710 4720 4730 4740 4750
STLETSAGTP SVVTEGFAHS KITTAMNNDV KDVSQTNPPF QDEASSPSSQ
4760 4770 4780 4790 4800
APVLVTTLPS SVAFTPQWHS TSSPVSMSSV LTSSLVKTAG KVDTSLETVT
4810 4820 4830 4840 4850
SSPQSMSNTL DDISVTSAAT TDIETTHPSI NTVVTNVGTT GSAFESHSTV
4860 4870 4880 4890 4900
SAYPEPSKVT SPNVTTSTME DTTISRSIPK SSKTTRTETE TTSSLTPKLR
4910 4920 4930 4940 4950
ETSISQEITS STETSTVPYK ELTGATTEVS RTDVTSSSST SFPGPDQSTV
4960 4970 4980 4990 5000
SLDISTETNT RLSTSPIMTE SAEITITTQT GPHGATSQDT FTMDPSNTTP
5010 5020 5030 5040 5050
QAGIHSAMTH GFSQLDVTTL MSRIPQDVSW TSPPSVDKTS SPSSFLSSPA
5060 5070 5080 5090 5100
MTTPSLISST LPEDKLSSPM TSLLTSGLVK ITDILRTRLE PVTSSLPNFS
5110 5120 5130 5140 5150
STSDKILATS KDSKDTKEIF PSINTEETNV KANNSGHESH SPALADSETP
5160 5170 5180 5190 5200
KATTQMVITT TVGDPAPSTS MPVHGSSETT NIKREPTYFL TPRLRETSTS
5210 5220 5230 5240 5250
QESSFPTDTS FLLSKVPTGT ITEVSSTGVN SSSKISTPDH DKSTVPPDTF
5260 5270 5280 5290 5300
TGEIPRVFTS SIKTKSAEMT ITTQASPPES ASHSTLPLDT STTLSQGGTH
5310 5320 5330 5340 5350
STVTQGFPYS EVTTLMGMGP GNVSWMTTPP VEETSSVSSL MSSPAMTSPS
5360 5370 5380 5390 5400
PVSSTSPQSI PSSPLPVTAL PTSVLVTTTD VLGTTSPESV TSSPPNLSSI
5410 5420 5430 5440 5450
THERPATYKD TAHTEAAMHH STNTAVTNVG TSGSGHKSQS SVLADSETSK
5460 5470 5480 5490 5500
ATPLMSTTST LGDTSVSTST PNISQTNQIQ TEPTASLSPR LRESSTSEKT
5510 5520 5530 5540 5550
SSTTETNTAF SYVPTGAITQ ASRTEISSSR TSISDLDRPT IAPDISTGMI
5560 5570 5580 5590 5600
TRLFTSPIMT KSAEMTVTTQ TTTPGATSQG ILPWDTSTTL FQGGTHSTVS
5610 5620 5630 5640 5650
QGFPHSEITT LRSRTPGDVS WMTTPPVEET SSGFSLMSPS MTSPSPVSST
5660 5670 5680 5690 5700
SPESIPSSPL PVTALLTSVL VTTTNVLGTT SPETVTSSPP NLSSPTQERL
5710 5720 5730 5740 5750
TTYKDTAHTE AMHASMHTNT AVANVGTSIS GHESQSSVPA DSHTSKATSP
5760 5770 5780 5790 5800
MGITFAMGDT SVSTSTPAFF ETRIQTESTS SLIPGLRDTR TSEEINTVTE
5810 5820 5830 5840 5850
TSTVLSEVPT TTTTEVSRTE VITSSRTTIS GPDHSKMSPY ISTETITRLS
5860 5870 5880 5890 5900
TFPFVTGSTE MAITNQTGPI GTISQATLTL DTSSTASWEG THSPVTQRFP
5910 5920 5930 5940 5950
HSEETTTMSR STKGVSWQSP PSVEETSSPS SPVPLPAITS HSSLYSAVSG
5960 5970 5980 5990 6000
SSPTSALPVT SLLTSGRRKT IDMLDTHSEL VTSSLPSASS FSGEILTSEA
6010 6020 6030 6040 6050
STNTETIHFS ENTAETNMGT TNSMHKLHSS VSIHSQPSGH TPPKVTGSMM
6060 6070 6080 6090 6100
EDAIVSTSTP GSPETKNVDR DSTSPLTPEL KEDSTALVMN STTESNTVFS
6110 6120 6130 6140 6150
SVSLDAATEV SRAEVTYYDP TFMPASAQST KSPDISPEAS SSHSNSPPLT
6160 6170 6180 6190 6200
ISTHKTIATQ TGPSGVTSLG QLTLDTSTIA TSAGTPSART QDFVDSETTS
6210 6220 6230 6240 6250
VMNNDLNDVL KTSPFSAEEA NSLSSQAPLL VTTSPSPVTS TLQEHSTSSL
6260 6270 6280 6290 6300
VSVTSVPTPT LAKITDMDTN LEPVTRSPQN LRNTLATSEA TTDTHTMHPS
6310 6320 6330 6340 6350
INTAMANVGT TSSPNEFYFT VSPDSDPYKA TSAVVITSTS GDSIVSTSMP
6360 6370 6380 6390 6400
RSSAMKKIES ETTFSLIFRL RETSTSQKIG SSSDTSTVFD KAFTAATTEV
6410 6420 6430 6440 6450
SRTELTSSSR TSIQGTEKPT MSPDTSTRSV TMLSTFAGLT KSEERTIATQ
6460 6470 6480 6490 6500
TGPHRATSQG TLTWDTSITT SQAGTHSAMT HGFSQLDLST LTSRVPEYIS
6510 6520 6530 6540 6550
GTSPPSVEKT SSSSSLLSLP AITSPSPVPT TLPESRPSSP VHLTSLPTSG
6560 6570 6580 6590 6600
LVKTTDMLAS VASLPPNLGS TSHKIPTTSE DIKDTEKMYP STNIAVTNVG
6610 6620 6630 6640 6650
TTTSEKESYS SVPAYSEPPK VTSPMVTSFN IRDTIVSTSM PGSSEITRIE
6660 6670 6680 6690 6700
MESTFSVAHG LKGTSTSQDP IVSTEKSAVL HKLTTGATET SRTEVASSRR
6710 6720 6730 6740 6750
TSIPGPDHST ESPDISTEVI PSLPISLGIT ESSNMTIITR TGPPLGSTSQ
6760 6770 6780 6790 6800
GTFTLDTPTT SSRAGTHSMA TQEFPHSEMT TVMNKDPEIL SWTIPPSIEK
6810 6820 6830 6840 6850
TSFSSSLMPS PAMTSPPVSS TLPKTIHTTP SPMTSLLTPS LVMTTDTLGT
6860 6870 6880 6890 6900
SPEPTTSSPP NLSSTSHVIL TTDEDTTAIE AMHPSTSTAA TNVETTCSGH
6910 6920 6930 6940 6950
GSQSSVLTDS EKTKATAPMD TTSTMGHTTV STSMSVSSET TKIKRESTYS
6960 6970 6980 6990 7000
LTPGLRETSI SQNASFSTDT SIVLSEVPTG TTAEVSRTEV TSSGRTSIPG
7010 7020 7030 7040 7050
PSQSTVLPEI STRTMTRLFA SPTMTESAEM TIPTQTGPSG STSQDTLTLD
7060 7070 7080 7090 7100
TSTTKSQAKT HSTLTQRFPH SEMTTLMSRG PGDMSWQSSP SLENPSSLPS
7110 7120 7130 7140 7150
LLSLPATTSP PPISSTLPVT ISSSPLPVTS LLTSSPVTTT DMLHTSPELV
7160 7170 7180 7190 7200
TSSPPKLSHT SDERLTTGKD TTNTEAVHPS TNTAASNVEI PSFGHESPSS
7210 7220 7230 7240 7250
ALADSETSKA TSPMFITSTQ EDTTVAISTP HFLETSRIQK ESISSLSPKL
7260 7270 7280 7290 7300
RETGSSVETS SAIETSAVLS EVSIGATTEI SRTEVTSSSR TSISGSAEST
7310 7320 7330 7340 7350
MLPEISTTRK IIKFPTSPIL AESSEMTIKT QTSPPGSTSE STFTLDTSTT
7360 7370 7380 7390 7400
PSLVITHSTM TQRLPHSEIT TLVSRGAGDV PRPSSLPVEE TSPPSSQLSL
7410 7420 7430 7440 7450
SAMISPSPVS STLPASSHSS SASVTSPLTP GQVKTTEVLD ASAEPETSSP
7460 7470 7480 7490 7500
PSLSSTSVEI LATSEVTTDT EKIHPFPNTA VTKVGTSSSG HESPSSVLPD
7510 7520 7530 7540 7550
SETTKATSAM GTISIMGDTS VSTLTPALSN TRKIQSEPAS SLTTRLRETS
7560 7570 7580 7590 7600
TSEETSLATE ANTVLSKVST GATTEVSRTE AISFSRTSMS GPEQSTMSQD
7610 7620 7630 7640 7650
ISIGTIPRIS ASSVLTESAK MTITTQTGPS ESTLESTLNL NTATTPSWVE
7660 7670 7680 7690 7700
THSIVIQGFP HPEMTTSMGR GPGGVSWPSP PFVKETSPPS SPLSLPAVTS
7710 7720 7730 7740 7750
PHPVSTTFLA HIPPSPLPVT SLLTSGPATT TDILGTSTEP GTSSSSSLST
7760 7770 7780 7790 7800
TSHERLTTYK DTAHTEAVHP STNTGGTNVA TTSSGYKSQS SVLADSSPMC
7810 7820 7830 7840 7850
TTSTMGDTSV LTSTPAFLET RRIQTELASS LTPGLRESSG SEGTSSGTKM
7860 7870 7880 7890 7900
STVLSKVPTG ATTEISKEDV TSIPGPAQST ISPDISTRTV SWFSTSPVMT
7910 7920 7930 7940 7950
ESAEITMNTH TSPLGATTQG TSTLATSSTT SLTMTHSTIS QGFSHSQMST
7960 7970 7980 7990 8000
LMRRGPEDVS WMSPPLLEKT RPSFSLMSSP ATTSPSPVSS TLPESISSSP
8010 8020 8030 8040 8050
LPVTSLLTSG LAKTTDMLHK SSEPVTNSPA NLSSTSVEIL ATSEVTTDTE
8060 8070 8080 8090 8100
KTHPSSNRTV TDVGTSSSGH ESTSFVLADS QTSKVTSPMV ITSTMEDTSV
8110 8120 8130 8140 8150
STSTPGFFET SRIQTEPTSS LTLGLRKTSS SEGTSLATEM STVLSGVPTG
8160 8170 8180 8190 8200
ATAEVSRTEV TSSSRTSISG FAQLTVSPET STETITRLPT SSIMTESAEM
8210 8220 8230 8240 8250
MIKTQTDPPG STPESTHTVD ISTTPNWVET HSTVTQRFSH SEMTTLVSRS
8260 8270 8280 8290 8300
PGDMLWPSQS SVEETSSASS LLSLPATTSP SPVSSTLVED FPSASLPVTS
8310 8320 8330 8340 8350
LLTPGLVITT DRMGISREPG TSSTSNLSST SHERLTTLED TVDTEDMQPS
8360 8370 8380 8390 8400
THTAVTNVRT SISGHESQSS VLSDSETPKA TSPMGTTYTM GETSVSISTS
8410 8420 8430 8440 8450
DFFETSRIQI EPTSSLTSGL RETSSSERIS SATEGSTVLS EVPSGATTEV
8460 8470 8480 8490 8500
SRTEVISSRG TSMSGPDQFT ISPDISTEAI TRLSTSPIMT ESAESAITIE
8510 8520 8530 8540 8550
TGSPGATSEG TLTLDTSTTT FWSGTHSTAS PGFSHSEMTT LMSRTPGDVP
8560 8570 8580 8590 8600
WPSLPSVEEA SSVSSSLSSP AMTSTSFFSA LPESISSSPH PVTALLTLGP
8610 8620 8630 8640 8650
VKTTDMLRTS SEPETSSPPN LSSTSAEILA TSEVTKDREK IHPSSNTPVV
8660 8670 8680 8690 8700
NVGTVIYKHL SPSSVLADLV TTKPTSPMAT TSTLGNTSVS TSTPAFPETM
8710 8720 8730 8740 8750
MTQPTSSLTS GLREISTSQE TSSATERSAS LSGMPTGATT KVSRTEALSL
8760 8770 8780 8790 8800
GRTSTPGPAQ STISPEISTE TITRISTPLT TTGSAEMTIT PKTGHSGASS
8810 8820 8830 8840 8850
QGTFTLDTSS RASWPGTHSA ATHRSPHSGM TTPMSRGPED VSWPSRPSVE
8860 8870 8880 8890 8900
KTSPPSSLVS LSAVTSPSPL YSTPSESSHS SPLRVTSLFT PVMMKTTDML
8910 8920 8930 8940 8950
DTSLEPVTTS PPSMNITSDE SLATSKATME TEAIQLSENT AVTQMGTISA
8960 8970 8980 8990 9000
RQEFYSSYPG LPEPSKVTSP VVTSSTIKDI VSTTIPASSE ITRIEMESTS
9010 9020 9030 9040 9050
TLTPTPRETS TSQEIHSATK PSTVPYKALT SATIEDSMTQ VMSSSRGPSP
9060 9070 9080 9090 9100
DQSTMSQDIS SEVITRLSTS PIKAESTEMT ITTQTGSPGA TSRGTLTLDT
9110 9120 9130 9140 9150
STTFMSGTHS TASQGFSHSQ MTALMSRTPG DVPWLSHPSV EEASSASFSL
9160 9170 9180 9190 9200
SSPVMTSSSP VSSTLPDSIH SSSLPVTSLL TSGLVKTTEL LGTSSEPETS
9210 9220 9230 9240 9250
SPPNLSSTSA EILATTEVTT DTEKLEMTNV VTSGYTHESP SSVLADSVTT
9260 9270 9280 9290 9300
KATSSMGITY PTGDTNVLTS TPAFSDTSRI QTKSKLSLTP GLMETSISEE
9310 9320 9330 9340 9350
TSSATEKSTV LSSVPTGATT EVSRTEAISS SRTSIPGPAQ STMSSDTSME
9360 9370 9380 9390 9400
TITRISTPLT RKESTDMAIT PKTGPSGATS QGTFTLDSSS TASWPGTHSA
9410 9420 9430 9440 9450
TTQRFPQSVV TTPMSRGPED VSWPSPLSVE KNSPPSSLVS SSSVTSPSPL
9460 9470 9480 9490 9500
YSTPSGSSHS SPVPVTSLFT SIMMKATDML DASLEPETTS APNMNITSDE
9510 9520 9530 9540 9550
SLATSKATTE TEAIHVFENT AASHVETTSA TEELYSSSPG FSEPTKVISP
9560 9570 9580 9590 9600
VVTSSSIRDN MVSTTMPGSS GITRIEIESM SSLTPGLRET RTSQDITSST
9610 9620 9630 9640 9650
ETSTVLYKMS SGATPEVSRT EVMPSSRTSI PGPAQSTMSL DISDEVVTRL
9660 9670 9680 9690 9700
STSPIMTESA EITITTQTGY SLATSQVTLP LGTSMTFLSG THSTMSQGLS
9710 9720 9730 9740 9750
HSEMTNLMSR GPESLSWTSP RFVETTRSSS SLTSLPLTTS LSPVSSTLLD
9760 9770 9780 9790 9800
SSPSSPLPVT SLILPGLVKT TEVLDTSSEP KTSSSPNLSS TSVEIPATSE
9810 9820 9830 9840 9850
IMTDTEKIHP SSNTAVAKVR TSSSVHESHS SVLADSETTI TIPSMGITSA
9860 9870 9880 9890 9900
VDDTTVFTSN PAFSETRRIP TEPTFSLTPG FRETSTSEET TSITETSAVL
9910 9920 9930 9940 9950
YGVPTSATTE VSMTEIMSSN RTHIPDSDQS TMSPDIITEV ITRLSSSSMM
9960 9970 9980 9990 10000
SESTQMTITT QKSSPGATAQ STLTLATTTA PLARTHSTVP PRFLHSEMTT
10010 10020 10030 10040 10050
LMSRSPENPS WKSSPFVEKT SSSSSLLSLP VTTSPSVSST LPQSIPSSSF
10060 10070 10080 10090 10100
SVTSLLTPGM VKTTDTSTEP GTSLSPNLSG TSVEILAASE VTTDTEKIHP
10110 10120 10130 10140 10150
SSSMAVTNVG TTSSGHELYS SVSIHSEPSK ATYPVGTPSS MAETSISTSM
10160 10170 10180 10190 10200
PANFETTGFE AEPFSHLTSG FRKTNMSLDT SSVTPTNTPS SPGSTHLLQS
10210 10220 10230 10240 10250
SKTDFTSSAK TSSPDWPPAS QYTEIPVDII TPFNASPSIT ESTGITSFPE
10260 10270 10280 10290 10300
SRFTMSVTES THHLSTDLLP SAETISTGTV MPSLSEAMTS FATTGVPRAI
10310 10320 10330 10340 10350
SGSGSPFSRT ESGPGDATLS TIAESLPSST PVPFSSSTFT TTDSSTIPAL
10360 10370 10380 10390 10400
HEITSSSATP YRVDTSLGTE SSTTEGRLVM VSTLDTSSQP GRTSSTPILD
10410 10420 10430 10440 10450
TRMTESVELG TVTSAYQVPS LSTRLTRTDG IMEHITKIPN EAAHRGTIRP
10460 10470 10480 10490 10500
VKGPQTSTSP ASPKGLHTGG TKRMETTTTA LKTTTTALKT TSRATLTTSV
10510 10520 10530 10540 10550
YTPTLGTLTP LNASRQMAST ILTEMMITTP YVFPDVPETT SSLATSLGAE
10560 10570 10580 10590 10600
TSTALPRTTP SVLNRESETT ASLVSRSGAE RSPVIQTLDV SSSEPDTTAS
10610 10620 10630 10640 10650
WVIHPAETIP TVSKTTPNFF HSELDTVSST ATSHGADVSS AIPTNISPSE
10660 10670 10680 10690 10700
LDALTPLVTI SGTDTSTTFP TLTKSPHETE TRTTWLTHPA ETSSTIPRTI
10710 10720 10730 10740 10750
PNFSHHESDA TPSIATSPGA ETSSAIPIMT VSPGAEDLVT SQVTSSGTDR
10760 10770 10780 10790 10800
NMTIPTLTLS PGEPKTIASL VTHPEAQTSS AIPTSTISPA VSRLVTSMVT
10810 10820 10830 10840 10850
SLAAKTSTTN RALTNSPGEP ATTVSLVTHP AQTSPTVPWT TSIFFHSKSD
10860 10870 10880 10890 10900
TTPSMTTSHG AESSSAVPTP TVSTEVPGVV TPLVTSSRAV ISTTIPILTL
10910 10920 10930 10940 10950
SPGEPETTPS MATSHGEEAS SAIPTPTVSP GVPGVVTSLV TSSRAVTSTT
10960 10970 10980 10990 11000
IPILTFSLGE PETTPSMATS HGTEAGSAVP TVLPEVPGMV TSLVASSRAV
11010 11020 11030 11040 11050
TSTTLPTLTL SPGEPETTPS MATSHGAEAS STVPTVSPEV PGVVTSLVTS
11060 11070 11080 11090 11100
SSGVNSTSIP TLILSPGELE TTPSMATSHG AEASSAVPTP TVSPGVSGVV
11110 11120 11130 11140 11150
TPLVTSSRAV TSTTIPILTL SSSEPETTPS MATSHGVEAS SAVLTVSPEV
11160 11170 11180 11190 11200
PGMVTSLVTS SRAVTSTTIP TLTISSDEPE TTTSLVTHSE AKMISAIPTL
11210 11220 11230 11240 11250
AVSPTVQGLV TSLVTSSGSE TSAFSNLTVA SSQPETIDSW VAHPGTEASS
11260 11270 11280 11290 11300
VVPTLTVSTG EPFTNISLVT HPAESSSTLP RTTSRFSHSE LDTMPSTVTS
11310 11320 11330 11340 11350
PEAESSSAIS TTISPGIPGV LTSLVTSSGR DISATFPTVP ESPHESEATA
11360 11370 11380 11390 11400
SWVTHPAVTS TTVPRTTPNY SHSEPDTTPS IATSPGAEAT SDFPTITVSP
11410 11420 11430 11440 11450
DVPDMVTSQV TSSGTDTSIT IPTLTLSSGE PETTTSFITY SETHTSSAIP
11460 11470 11480 11490 11500
TLPVSPGASK MLTSLVISSG TDSTTTFPTL TETPYEPETT AIQLIHPAET
11510 11520 11530 11540 11550
NTMVPKTTPK FSHSKSDTTL PVAITSPGPE ASSAVSTTTI SPDMSDLVTS
11560 11570 11580 11590 11600
LVPSSGTDTS TTFPTLSETP YEPETTVTWL THPAETSTTV SGTIPNFSHR
11610 11620 11630 11640 11650
GSDTAPSMVT SPGVDTRSGV PTTTIPPSIP GVVTSQVTSS ATDTSTAIPT
11660 11670 11680 11690 11700
LTPSPGEPET TASSATHPGT QTGFTVPIRT VPSSEPDTMA SWVTHPPQTS
11710 11720 11730 11740 11750
TPVSRTTSSF SHSSPDATPV MATSPRTEAS SAVLTTISPG APEMVTSQIT
11760 11770 11780 11790 11800
SSGAATSTTV PTLTHSPGMP ETTALLSTHP RTGTSKTFPA STVFPQVSET
11810 11820 11830 11840 11850
TASLTIRPGA ETSTALPTQT TSSLFTLLVT GTSRVDLSPT ASPGVSAKTA
11860 11870 11880 11890 11900
PLSTHPGTET STMIPTSTLS LGLLETTGLL ATSSSAETST STLTLTVSPA
11910 11920 11930 11940 11950
VSGLSSASIT TDKPQTVTSW NTETSPSVTS VGPPEFSRTV TGTTMTLIPS
11960 11970 11980 11990 12000
EMPTPPKTSH GEGVSPTTIL RTTMVEATNL ATTGSSPTVA KTTTTFNTLA
12010 12020 12030 12040 12050
GSLFTPLTTP GMSTLASESV TSRTSYNHRS WISTTSSYNR RYWTPATSTP
12060 12070 12080 12090 12100
VTSTFSPGIS TSSIPSSTAA TVPFMVPFTL NFTITNLQYE EDMRHPGSRK
12110 12120 12130 12140 12150
FNATERELQG LLKPLFRNSS LEYLYSGCRL ASLRPEKDSS AMAVDAICTH
12160 12170 12180 12190 12200
RPDPEDLGLD RERLYWELSN LTNGIQELGP YTLDRNSLYV NGFTHRSSMP
12210 12220 12230 12240 12250
TTSTPGTSTV DVGTSGTPSS SPSPTAAGPL LMPFTLNFTI TNLQYEEDMR
12260 12270 12280 12290 12300
RTGSRKFNTM ESVLQGLLKP LFKNTSVGPL YSGCRLTLLR PEKDGAATGV
12310 12320 12330 12340 12350
DAICTHRLDP KSPGLNREQL YWELSKLTND IEELGPYTLD RNSLYVNGFT
12360 12370 12380 12390 12400
HQSSVSTTST PGTSTVDLRT SGTPSSLSSP TIMAAGPLLV PFTLNFTITN
12410 12420 12430 12440 12450
LQYGEDMGHP GSRKFNTTER VLQGLLGPIF KNTSVGPLYS GCRLTSLRSE
12460 12470 12480 12490 12500
KDGAATGVDA ICIHHLDPKS PGLNRERLYW ELSQLTNGIK ELGPYTLDRN
12510 12520 12530 12540 12550
SLYVNGFTHR TSVPTTSTPG TSTVDLGTSG TPFSLPSPAT AGPLLVLFTL
12560 12570 12580 12590 12600
NFTITNLKYE EDMHRPGSRK FNTTERVLQT LLGPMFKNTS VGLLYSGCRL
12610 12620 12630 12640 12650
TLLRSEKDGA ATGVDAICTH RLDPKSPGLD REQLYWELSQ LTNGIKELGP
12660 12670 12680 12690 12700
YTLDRNSLYV NGFTHWIPVP TSSTPGTSTV DLGSGTPSSL PSPTAAGPLL
12710 12720 12730 12740 12750
VPFTLNFTIT NLQYEEDMHH PGSRKFNTTE RVLQGLLGPM FKNTSVGLLY
12760 12770 12780 12790 12800
SGCRLTLLRS EKDGAATGVD AICTHRLDPK SPGVDREQLY WELSQLTNGI
12810 12820 12830 12840 12850
KELGPYTLDR NSLYVNGFTH QTSAPNTSTP GTSTVDLGTS GTPSSLPSPT
12860 12870 12880 12890 12900
SAGPLLVPFT LNFTITNLQY EEDMRHPGSR KFNTTERVLQ GLLKPLFKST
12910 12920 12930 12940 12950
SVGPLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGV DREQLYWELS
12960 12970 12980 12990 13000
QLTNGIKELG PYTLDRNSLY VNGFTHQTSA PNTSTPGTST VDLGTSGTPS
13010 13020 13030 13040 13050
SLPSPTSAGP LLVPFTLNFT ITNLQYEEDM HHPGSRKFNT TERVLQGLLG
13060 13070 13080 13090 13100
PMFKNTSVGL LYSGCRLTLL RPEKNGAATG MDAICSHRLD PKSPGLNREQ
13110 13120 13130 13140 13150
LYWELSQLTH GIKELGPYTL DRNSLYVNGF THRSSVAPTS TPGTSTVDLG
13160 13170 13180 13190 13200
TSGTPSSLPS PTTAVPLLVP FTLNFTITNL QYGEDMRHPG SRKFNTTERV
13210 13220 13230 13240 13250
LQGLLGPLFK NSSVGPLYSG CRLISLRSEK DGAATGVDAI CTHHLNPQSP
13260 13270 13280 13290 13300
GLDREQLYWQ LSQMTNGIKE LGPYTLDRNS LYVNGFTHRS SGLTTSTPWT
13310 13320 13330 13340 13350
STVDLGTSGT PSPVPSPTTA GPLLVPFTLN FTITNLQYEE DMHRPGSRKF
13360 13370 13380 13390 13400
NTTERVLQGL LSPIFKNSSV GPLYSGCRLT SLRPEKDGAA TGMDAVCLYH
13410 13420 13430 13440 13450
PNPKRPGLDR EQLYWELSQL THNITELGPY SLDRDSLYVN GFTHQNSVPT
13460 13470 13480 13490 13500
TSTPGTSTVY WATTGTPSSF PGHTEPGPLL IPFTFNFTIT NLHYEENMQH
13510 13520 13530 13540 13550
PGSRKFNTTE RVLQGLLKPL FKNTSVGPLY SGCRLTSLRP EKDGAATGMD
13560 13570 13580 13590 13600
AVCLYHPNPK RPGLDREQLY WELSQLTHNI TELGPYSLDR DSLYVNGFTH
13610 13620 13630 13640 13650
QNSVPTTSTP GTSTVYWATT GTPSSFPGHT EPGPLLIPFT FNFTITNLHY
13660 13670 13680 13690 13700
EENMQHPGSR KFNTTERVLQ GLLKPLFKNT SVGPLYSGCR LTLLRPEKHE
13710 13720 13730 13740 13750
AATGVDTICT HRVDPIGPGL DRERLYWELS QLTNSITELG PYTLDRDSLY
13760 13770 13780 13790 13800
VNGFNPRSSV PTTSTPGTST VHLATSGTPS SLPGHTAPVP LLIPFTLNFT
13810 13820 13830 13840 13850
ITNLHYEENM QHPGSRKFNT TERVLQGLLK PLFKNTSVGP LYSGCRLTLL
13860 13870 13880 13890 13900
RPEKHEAATG VDTICTHRVD PIGPGLXXEX LYWELSXLTX XIXELGPYTL
13910 13920 13930 13940 13950
DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX XTSAGPLLVP
13960 13970 13980 13990 14000
FTLNFTITNL QYEEDMHHPG SRKFNTTERV LQGLLGPMFK NTSVGLLYSG
14010 14020 14030 14040 14050
CRLTLLRPEK NGAATGMDAI CSHRLDPKSP GLDREQLYWE LSQLTHGIKE
14060 14070 14080 14090 14100
LGPYTLDRNS LYVNGFTHRS SVAPTSTPGT STVDLGTSGT PSSLPSPTTA
14110 14120 14130 14140 14150
VPLLVPFTLN FTITNLQYGE DMRHPGSRKF NTTERVLQGL LGPLFKNSSV
14160 14170 14180 14190 14200
GPLYSGCRLI SLRSEKDGAA TGVDAICTHH LNPQSPGLDR EQLYWQLSQM
14210 14220 14230 14240 14250
TNGIKELGPY TLDRNSLYVN GFTHRSSGLT TSTPWTSTVD LGTSGTPSPV
14260 14270 14280 14290 14300
PSPTTAGPLL VPFTLNFTIT NLQYEEDMHR PGSRKFNATE RVLQGLLSPI
14310 14320 14330 14340 14350
FKNSSVGPLY SGCRLTSLRP EKDGAATGMD AVCLYHPNPK RPGLDREQLY
14360 14370 14380 14390 14400
WELSQLTHNI TELGPYSLDR DSLYVNGFTH QSSMTTTRTP DTSTMHLATS
14410 14420 14430 14440 14450
RTPASLSGPT TASPLLVLFT INCTITNLQY EEDMRRTGSR KFNTMESVLQ
14460 14470 14480 14490 14500
GLLKPLFKNT SVGPLYSGCR LTLLRPKKDG AATGVDAICT HRLDPKSPGL
14510 14520 14530 14540 14550
NREQLYWELS KLTNDIEELG PYTLDRNSLY VNGFTHQSSV STTSTPGTST
14560 14570 14580 14590 14600
VDLRTSGTPS SLSSPTIMXX XPLLXPFTXN XTITNLXXXX XMXXPGSRKF
14610 14620 14630 14640 14650
NTTERVLQGL LRPLFKNTSV SSLYSGCRLT LLRPEKDGAA TRVDAACTYR
14660 14670 14680 14690 14700
PDPKSPGLDR EQLYWELSQL THSITELGPY TLDRVSLYVN GFNPRSSVPT
14710 14720 14730 14740 14750
TSTPGTSTVH LATSGTPSSL PGHTXXXPLL XPFTXNXTIT NLXXXXXMXX
14760 14770 14780 14790 14800
PGSRKFNTTE RVLQGLLKPL FRNSSLEYLY SGCRLASLRP EKDSSAMAVD
14810 14820 14830 14840 14850
AICTHRPDPE DLGLDRERLY WELSNLTNGI QELGPYTLDR NSLYVNGFTH
14860 14870 14880 14890 14900
RSSGLTTSTP WTSTVDLGTS GTPSPVPSPT TAGPLLVPFT LNFTITNLQY
14910 14920 14930 14940 14950
EEDMHRPGSR RFNTTERVLQ GLLTPLFKNT SVGPLYSGCR LTLLRPEKQE
14960 14970 14980 14990 15000
AATGVDTICT HRVDPIGPGL DRERLYWELS QLTNSITELG PYTLDRDSLY
15010 15020 15030 15040 15050
VNGFNPWSSV PTTSTPGTST VHLATSGTPS SLPGHTAPVP LLIPFTLNFT
15060 15070 15080 15090 15100
ITDLHYEENM QHPGSRKFNT TERVLQGLLK PLFKSTSVGP LYSGCRLTLL
15110 15120 15130 15140 15150
RPEKHGAATG VDAICTLRLD PTGPGLDRER LYWELSQLTN SVTELGPYTL
15160 15170 15180 15190 15200
DRDSLYVNGF THRSSVPTTS IPGTSAVHLE TSGTPASLPG HTAPGPLLVP
15210 15220 15230 15240 15250
FTLNFTITNL QYEEDMRHPG SRKFSTTERV LQGLLKPLFK NTSVSSLYSG
15260 15270 15280 15290 15300
CRLTLLRPEK DGAATRVDAV CTHRPDPKSP GLDRERLYWK LSQLTHGITE
15310 15320 15330 15340 15350
LGPYTLDRHS LYVNGFTHQS SMTTTRTPDT STMHLATSRT PASLSGPTTA
15360 15370 15380 15390 15400
SPLLVLFTIN FTITNLRYEE NMHHPGSRKF NTTERVLQGL LRPVFKNTSV
15410 15420 15430 15440 15450
GPLYSGCRLT TLRPKKDGAA TKVDAICTYR PDPKSPGLDR EQLYWELSQL
15460 15470 15480 15490 15500
THSITELGPY TQDRDSLYVN GFTHRSSVPT TSIPGTSAVH LETSGTPASL
15510 15520 15530 15540 15550
PGHTAPGPLL VPFTLNFTIT NLQYEEDMRH PGSRKFNTTE RVLQGLLKPL
15560 15570 15580 15590 15600
FKSTSVGPLY SGCRLTLLRP EKRGAATGVD TICTHRLDPL NPGLDREQLY
15610 15620 15630 15640 15650
WELSKLTRGI IELGPYLLDR GSLYVNGFTH RTSVPTTSTP GTSTVDLGTS
15660 15670 15680 15690 15700
GTPFSLPSPA XXXPLLXPFT XNXTITNLXX XXXMXXPGSR KFNTTERVLQ
15710 15720 15730 15740 15750
TLLGPMFKNT SVGLLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGV
15760 15770 15780 15790 15800
DREQLYWELS QLTNGIKELG PYTLDRNSLY VNGFTHWIPV PTSSTPGTST
15810 15820 15830 15840 15850
VDLGSGTPSS LPSPTTAGPL LVPFTLNFTI TNLKYEEDMH CPGSRKFNTT
15860 15870 15880 15890 15900
ERVLQSLLGP MFKNTSVGPL YSGCRLTLLR SEKDGAATGV DAICTHRLDP
15910 15920 15930 15940 15950
KSPGVDREQL YWELSQLTNG IKELGPYTLD RNSLYVNGFT HQTSAPNTST
15960 15970 15980 15990 16000
PGTSTVDLGT SGTPSSLPSP TXXXPLLXPF TXNXTITNLX XXXXMXXPGS
16010 16020 16030 16040 16050
RKFNTTEXVL QGLLXPXFKN XSVGXLYSGC RLTXLRXEKX GAATGXDAIC
16060 16070 16080 16090 16100
XHXXXPKXPG LXXEXLYWEL SXLTXXIXEL GPYTLDRXSL YVNGFTHWIP
16110 16120 16130 16140 16150
VPTSSTPGTS TVDLGSGTPS SLPSPTTAGP LLVPFTLNFT ITNLKYEEDM
16160 16170 16180 16190 16200
HCPGSRKFNT TERVLQSLLG PMFKNTSVGP LYSGCRLTSL RSEKDGAATG
16210 16220 16230 16240 16250
VDAICTHRVD PKSPGVDREQ LYWELSQLTN GIKELGPYTL DRNSLYVNGF
16260 16270 16280 16290 16300
THQTSAPNTS TPGTSTVXXG TSGTPSSXPX XTSAGPLLVP FTLNFTITNL
16310 16320 16330 16340 16350
QYEEDMHHPG SRKFNTTERV LQGLLGPMFK NTSVGLLYSG CRLTLLRPEK
16360 16370 16380 16390 16400
NGATTGMDAI CTHRLDPKSP GLXXEXLYWE LSXLTXXIXE LGPYTLDRXS
16410 16420 16430 16440 16450
LYVNGFTHXX SXPTTSTPGT STVXXGTSGT PSSXPXXTXX XPLLXPFTXN
16460 16470 16480 16490 16500
XTITNLXXXX XMXXPGSRKF NTTERVLQGL LKPLFRNSSL EYLYSGCRLA
16510 16520 16530 16540 16550
SLRPEKDSSA MAVDAICTHR PDPEDLGLDR ERLYWELSNL TNGIQELGPY
16560 16570 16580 16590 16600
TLDRNSLYVN GFTHRSSMPT TSTPGTSTVD VGTSGTPSSS PSPTTAGPLL
16610 16620 16630 16640 16650
IPFTLNFTIT NLQYGEDMGH PGSRKFNTTE RVLQGLLGPI FKNTSVGPLY
16660 16670 16680 16690 16700
SGCRLTSLRS EKDGAATGVD AICIHHLDPK SPGLNRERLY WELSQLTNGI
16710 16720 16730 16740 16750
KELGPYTLDR NSLYVNGFTH RTSVPTTSTP GTSTVDLGTS GTPFSLPSPA
16760 16770 16780 16790 16800
TAGPLLVLFT LNFTITNLKY EEDMHRPGSR KFNTTERVLQ TLLGPMFKNT
16810 16820 16830 16840 16850
SVGLLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGL XXEXLYWELS
16860 16870 16880 16890 16900
XLTXXIXELG PYTLDRXSLY VNGFTHXXSX PTTSTPGTST VXXGTSGTPS
16910 16920 16930 16940 16950
SXPXXTXXXP LLXPFTXNXT ITNLXXXXXM XXPGSRKFNT TERVLQGLLR
16960 16970 16980 16990 17000
PVFKNTSVGP LYSGCRLTLL RPKKDGAATK VDAICTYRPD PKSPGLDREQ
17010 17020 17030 17040 17050
LYWELSQLTH SITELGPYTQ DRDSLYVNGF THRSSVPTTS IPGTSAVHLE
17060 17070 17080 17090 17100
TTGTPSSFPG HTEPGPLLIP FTFNFTITNL RYEENMQHPG SRKFNTTERV
17110 17120 17130 17140 17150
LQGLLTPLFK NTSVGPLYSG CRLTLLRPEK QEAATGVDTI CTHRVDPIGP
17160 17170 17180 17190 17200
GLDRERLYWE LSQLTNSITE LGPYTLDRDS LYVDGFNPWS SVPTTSTPGT
17210 17220 17230 17240 17250
STVHLATSGT PSPLPGHTAP VPLLIPFTLN FTITDLHYEE NMQHPGSRKF
17260 17270 17280 17290 17300
NTTERVLQGL LKPLFKSTSV GPLYSGCRLT LLRPEKHGAA TGVDAICTLR
17310 17320 17330 17340 17350
LDPTGPGLDR ERLYWELSQL TNSITELGPY TLDRDSLYVN GFNPWSSVPT
17360 17370 17380 17390 17400
TSTPGTSTVH LATSGTPSSL PGHTTAGPLL VPFTLNFTIT NLKYEEDMHC
17410 17420 17430 17440 17450
PGSRKFNTTE RVLQSLHGPM FKNTSVGPLY SGCRLTLLRS EKDGAATGVD
17460 17470 17480 17490 17500
AICTHRLDPK SPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH
17510 17520 17530 17540 17550
XXSXPTTSTP GTSTVXXGTS GTPSSXPXXT XXXPLLXPFT XNXTITNLXX
17560 17570 17580 17590 17600
XXXMXXPGSR KFNTTEXVLQ GLLXPXFKNX SVGXLYSGCR LTXLRXEKXG
17610 17620 17630 17640 17650
AATGXDAICX HXXXPKXPGL XXEXLYWELS XLTNSITELG PYTLDRDSLY
17660 17670 17680 17690 17700
VNGFTHRSSM PTTSIPGTSA VHLETSGTPA SLPGHTAPGP LLVPFTLNFT
17710 17720 17730 17740 17750
ITNLQYEEDM RHPGSRKFNT TERVLQGLLK PLFKSTSVGP LYSGCRLTLL
17760 17770 17780 17790 17800
RPEKRGAATG VDTICTHRLD PLNPGLXXEX LYWELSXLTX XIXELGPYTL
17810 17820 17830 17840 17850
DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX XTXXXPLLXP
17860 17870 17880 17890 17900
FTXNXTITNL XXXXXMXXPG SRKFNTTEXV LQGLLXPXFK NXSVGXLYSG
17910 17920 17930 17940 17950
CRLTXLRXEK XGAATGXDAI CXHXXXPKXP GLXXEXLYWE LSXLTXXIXE
17960 17970 17980 17990 18000
LGPYTLDRXS LYVNGFHPRS SVPTTSTPGT STVHLATSGT PSSLPGHTAP
18010 18020 18030 18040 18050
VPLLIPFTLN FTITNLHYEE NMQHPGSRKF NTTERVLQGL LGPMFKNTSV
18060 18070 18080 18090 18100
GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLXX EXLYWELSXL
18110 18120 18130 18140 18150
TXXIXELGPY TLDRXSLYVN GFTHXXSXPT TSTPGTSTVX XGTSGTPSSX
18160 18170 18180 18190 18200
PXXTXXXPLL XPFTXNXTIT NLXXXXXMXX PGSRKFNTTE XVLQGLLXPX
18210 18220 18230 18240 18250
FKNXSVGXLY SGCRLTXLRX EKXGAATGXD AICXHXXXPK XPGLXXEXLY
18260 18270 18280 18290 18300
WELSXLTXXI XELGPYTLDR XSLYVNGFTH QNSVPTTSTP GTSTVYWATT
18310 18320 18330 18340 18350
GTPSSFPGHT EPGPLLIPFT FNFTITNLHY EENMQHPGSR KFNTTERVLQ
18360 18370 18380 18390 18400
GLLTPLFKNT SVGPLYSGCR LTLLRPEKQE AATGVDTICT HRVDPIGPGL
18410 18420 18430 18440 18450
XXEXLYWELS XLTXXIXELG PYTLDRXSLY VNGFTHXXSX PTTSTPGTST
18460 18470 18480 18490 18500
VXXGTSGTPS SXPXXTXXXP LLXPFTXNXT ITNLXXXXXM XXPGSRKFNT
18510 18520 18530 18540 18550
TEXVLQGLLX PXFKNXSVGX LYSGCRLTXL RXEKXGAATG XDAICXHXXX
18560 18570 18580 18590 18600
PKXPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THRSSVPTTS
18610 18620 18630 18640 18650
SPGTSTVHLA TSGTPSSLPG HTAPVPLLIP FTLNFTITNL HYEENMQHPG
18660 18670 18680 18690 18700
SRKFNTTERV LQGLLKPLFK STSVGPLYSG CRLTLLRPEK HGAATGVDAI
18710 18720 18730 18740 18750
CTLRLDPTGP GLXXEXLYWE LSXLTXXIXE LGPYTLDRXS LYVNGFTHXX
18760 18770 18780 18790 18800
SXPTTSTPGT STVXXGTSGT PSSXPXXTXX XPLLXPFTXN XTITNLXXXX
18810 18820 18830 18840 18850
XMXXPGSRKF NTTEXVLQGL LXPXFKNXSV GXLYSGCRLT XLRXEKXGAA
18860 18870 18880 18890 18900
TGXDAICXHX XXPKXPGLXX EXLYWELSXL TXXIXELGPY TLDRXSLYVN
18910 18920 18930 18940 18950
GFTHRTSVPT TSTPGTSTVH LATSGTPSSL PGHTAPVPLL IPFTLNFTIT
18960 18970 18980 18990 19000
NLQYEEDMHR PGSRKFNTTE RVLQGLLSPI FKNSSVGPLY SGCRLTSLRP
19010 19020 19030 19040 19050
EKDGAATGMD AVCLYHPNPK RPGLDREQLY CELSQLTHNI TELGPYSLDR
19060 19070 19080 19090 19100
DSLYVNGFTH QNSVPTTSTP GTSTVYWATT GTPSSFPGHT XXXPLLXPFT
19110 19120 19130 19140 19150
XNXTITNLXX XXXMXXPGSR KFNTTEXVLQ GLLXPXFKNX SVGXLYSGCR
19160 19170 19180 19190 19200
LTXLRXEKXG AATGXDAICX HXXXPKXPGL XXEXLYWELS XLTXXIXELG
19210 19220 19230 19240 19250
PYTLDRXSLY VNGFTHWSSG LTTSTPWTST VDLGTSGTPS PVPSPTTAGP
19260 19270 19280 19290 19300
LLVPFTLNFT ITNLQYEEDM HRPGSRKFNA TERVLQGLLS PIFKNTSVGP
19310 19320 19330 19340 19350
LYSGCRLTLL RPEKQEAATG VDTICTHRVD PIGPGLXXEX LYWELSXLTX
19360 19370 19380 19390 19400
XIXELGPYTL DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX
19410 19420 19430 19440 19450
XTXXXPLLXP FTXNXTITNL XXXXXMXXPG SRKFNTTEXV LQGLLXPXFK
19460 19470 19480 19490 19500
NXSVGXLYSG CRLTXLRXEK XGAATGXDAI CXHXXXPKXP GLXXEXLYWE
19510 19520 19530 19540 19550
LSXLTXXIXE LGPYTLDRXS LYVNGFTHRS FGLTTSTPWT STVDLGTSGT
19560 19570 19580 19590 19600
PSPVPSPTTA GPLLVPFTLN FTITNLQYEE DMHRPGSRKF NTTERVLQGL
19610 19620 19630 19640 19650
LTPLFRNTSV SSLYSGCRLT LLRPEKDGAA TRVDAVCTHR PDPKSPGLXX
19660 19670 19680 19690 19700
EXLYWELSXL TXXIXELGPY TLDRXSLYVN GFTHXXSXPT TSTPGTSTVX
19710 19720 19730 19740 19750
XGTSGTPSSX PXXTXXXPLL XPFTXNXTIT NLXXXXXMXX PGSRKFNTTE
19760 19770 19780 19790 19800
XVLQGLLXPX FKNXSVGXLY SGCRLTXLRX EKXGAATGXD AICXHXXXPK
19810 19820 19830 19840 19850
XPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH WIPVPTSSTP
19860 19870 19880 19890 19900
GTSTVDLGSG TPSSLPSPTT AGPLLVPFTL NFTITNLQYG EDMGHPGSRK
19910 19920 19930 19940 19950
FNTTERVLQG LLGPIFKNTS VGPLYSGCRL TSLRSEKDGA ATGVDAICIH
19960 19970 19980 19990 20000
HLDPKSPGLX XEXLYWELSX LTXXIXELGP YTLDRXSLYV NGFTHXXSXP
20010 20020 20030 20040 20050
TTSTPGTSTV XXGTSGTPSS XPXXTXXXPL LXPFTXNXTI TNLXXXXXMX
20060 20070 20080 20090 20100
XPGSRKFNTT EXVLQGLLXP XFKNXSVGXL YSGCRLTXLR XEKXGAATGX
20110 20120 20130 20140 20150
DAICXHXXXP KXPGLXXEXL YWELSXLTXX IXELGPYTLD RXSLYVNGFT
20160 20170 20180 20190 20200
HQTFAPNTST PGTSTVDLGT SGTPSSLPSP TSAGPLLVPF TLNFTITNLQ
20210 20220 20230 20240 20250
YEEDMHHPGS RKFNTTERVL QGLLGPMFKN TSVGLLYSGC RLTLLRPEKN
20260 20270 20280 20290 20300
GAATRVDAVC THRPDPKSPG LXXEXLYWEL SXLTXXIXEL GPYTLDRXSL
20310 20320 20330 20340 20350
YVNGFTHXXS XPTTSTPGTS TVXXGTSGTP SSXPXXTAPV PLLIPFTLNF
20360 20370 20380 20390 20400
TITNLHYEEN MQHPGSRKFN TTERVLQGLL KPLFKSTSVG PLYSGCRLTL
20410 20420 20430 20440 20450
LRPEKHGAAT GVDAICTLRL DPTGPGLDRE RLYWELSQLT NSVTELGPYT
20460 20470 20480 20490 20500
LDRDSLYVNG FTQRSSVPTT SIPGTSAVHL ETSGTPASLP GHTAPGPLLV
20510 20520 20530 20540 20550
PFTLNFTITN LQYEVDMRHP GSRKFNTTER VLQGLLKPLF KSTSVGPLYS
20560 20570 20580 20590 20600
GCRLTLLRPE KRGAATGVDT ICTHRLDPLN PGLDREQLYW ELSKLTRGII
20610 20620 20630 20640 20650
ELGPYLLDRG SLYVNGFTHR NFVPITSTPG TSTVHLGTSE TPSSLPRPIV
20660 20670 20680 20690 20700
PGPLLVPFTL NFTITNLQYE EAMRHPGSRK FNTTERVLQG LLRPLFKNTS
20710 20720 20730 20740 20750
IGPLYSSCRL TLLRPEKDKA ATRVDAICTH HPDPQSPGLN REQLYWELSQ
20760 20770 20780 20790 20800
LTHGITELGP YTLDRDSLYV DGFTHWSPIP TTSTPGTSIV NLGTSGIPPS
20810 20820 20830 20840 20850
LPETTXXXPL LXPFTXNXTI TNLXXXXXMX XPGSRKFNTT ERVLQGLLKP
20860 20870 20880 20890 20900
LFKSTSVGPL YSGCRLTLLR PEKDGVATRV DAICTHRPDP KIPGLDRQQL
20910 20920 20930 20940 20950
YWELSQLTHS ITELGPYTLD RDSLYVNGFT QRSSVPTTST PGTFTVQPET
20960 20970 20980 20990 21000
SETPSSLPGP TATGPVLLPF TLNFTITNLQ YEEDMHRPGS RKFNTTERVL
21010 21020 21030 21040 21050
QGLLMPLFKN TSVSSLYSGC RLTLLRPEKD GAATRVDAVC THRPDPKSPG
21060 21070 21080 21090 21100
LDRERLYWKL SQLTHGITEL GPYTLDRHSL YVNGFTHQSS MTTTRTPDTS
21110 21120 21130 21140 21150
TMHLATSRTP ASLSGPTTAS PLLVLFTINF TITNLRYEEN MHHPGSRKFN
21160 21170 21180 21190 21200
TTERVLQGLL RPVFKNTSVG PLYSGCRLTL LRPKKDGAAT KVDAICTYRP
21210 21220 21230 21240 21250
DPKSPGLDRE QLYWELSQLT HSITELGPYT LDRDSLYVNG FTQRSSVPTT
21260 21270 21280 21290 21300
SIPGTPTVDL GTSGTPVSKP GPSAASPLLV LFTLNFTITN LRYEENMQHP
21310 21320 21330 21340 21350
GSRKFNTTER VLQGLLRSLF KSTSVGPLYS GCRLTLLRPE KDGTATGVDA
21360 21370 21380 21390 21400
ICTHHPDPKS PRLDREQLYW ELSQLTHNIT ELGHYALDND SLFVNGFTHR
21410 21420 21430 21440 21450
SSVSTTSTPG TPTVYLGASK TPASIFGPSA ASHLLILFTL NFTITNLRYE
21460 21470 21480 21490 21500
ENMWPGSRKF NTTERVLQGL LRPLFKNTSV GPLYSGSRLT LLRPEKDGEA
21510 21520 21530 21540 21550
TGVDAICTHR PDPTGPGLDR EQLYLELSQL THSITELGPY TLDRDSLYVN
21560 21570 21580 21590 21600
GFTHRSSVPT TSTGVVSEEP FTLNFTINNL RYMADMGQPG SLKFNITDNV
21610 21620 21630 21640 21650
MKHLLSPLFQ RSSLGARYTG CRVIALRSVK NGAETRVDLL CTYLQPLSGP
21660 21670 21680 21690 21700
GLPIKQVFHE LSQQTHGITR LGPYSLDKDS LYLNGYNEPG LDEPPTTPKP
21710 21720 21730 21740 21750
ATTFLPPLSE ATTAMGYHLK TLTLNFTISN LQYSPDMGKG SATFNSTEGV
21760 21770 21780 21790 21800
LQHLLRPLFQ KSSMGPFYLG CQLISLRPEK DGAATGVDTT CTYHPDPVGP
21810 21820 21830 21840 21850
GLDIQQLYWE LSQLTHGVTQ LGFYVLDRDS LFINGYAPQN LSIRGEYQIN
21860 21870 21880 21890 21900
FHIVNWNLSN PDPTSSEYIT LLRDIQDKVT TLYKGSQLHD TFRFCLVTNL
21910 21920 21930 21940 21950
TMDSVLVTVK ALFSSNLDPS LVEQVFLDKT LNASFHWLGS TYQLVDIHVT
21960 21970 21980 21990 22000
EMESSVYQPT SSSSTQHFYL NFTITNLPYS QDKAQPGTTN YQRNKRNIED
22010 22020 22030 22040 22050
ALNQLFRNSS IKSYFSDCQV STFRSVPNRH HTGVDSLCNF SPLARRVDRV
22060 22070 22080 22090 22100
AIYEEFLRMT RNGTQLQNFT LDRSSVLVDG YSPNRNEPLT GNSDLPFWAV
22110 22120 22130 22140 22150
ILIGLAGLLG LITCLICGVL VTTRRRKKEG EYNVQQQCPG YYQSHLDLED

LQ
Length:22,152
Mass (Da):2,353,428
Last modified:March 1, 2003 - v2
Checksum:iB3E7BDF19997A440
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8346 – 83461D → A in AAK74120. (PubMed:11369781)Curated
Sequence conflicti8580 – 85801A → T in AAK74120. (PubMed:11369781)Curated
Sequence conflicti9061 – 90611S → T in AAK74120. (PubMed:11369781)Curated
Sequence conflicti9074 – 90741A → T in AAK74120. (PubMed:11369781)Curated
Sequence conflicti9131 – 91311D → E in AAK74120. (PubMed:11369781)Curated
Sequence conflicti9407 – 94071Q → R in AAK74120. (PubMed:11369781)Curated
Sequence conflicti9504 – 95041T → A in AAK74120. (PubMed:11369781)Curated
Sequence conflicti9610 – 96101S → P in AAK74120. (PubMed:11369781)Curated
Sequence conflicti9852 – 98521D → E in AAK74120. (PubMed:11369781)Curated
Sequence conflicti9901 – 99011Y → F in AAK74120. (PubMed:11369781)Curated
Sequence conflicti10171 – 101711F → L in AAK74120. (PubMed:11369781)Curated
Sequence conflicti10396 – 103961T → S in AAK74120. (PubMed:11369781)Curated
Sequence conflicti10515 – 105151R → M in AAK74120. (PubMed:11369781)Curated
Sequence conflicti10522 – 105221L → P in AAK74120. (PubMed:11369781)Curated
Sequence conflicti10563 – 105631L → F in AAK74120. (PubMed:11369781)Curated
Sequence conflicti10830 – 108301P → S in AAK74120. (PubMed:11369781)Curated
Sequence conflicti11156 – 111561S → F in AAK74120. (PubMed:11369781)Curated
Sequence conflicti11201 – 112011A → G in AAK74120. (PubMed:11369781)Curated
Sequence conflicti11457 – 114571G → D in AAK74120. (PubMed:11369781)Curated
Sequence conflicti11506 – 115061K → R in AAK74120. (PubMed:11369781)Curated
Sequence conflicti11577 – 115771V → A in AAK74120. (PubMed:11369781)Curated
Sequence conflicti11783 – 117831G → E in AAK74120. (PubMed:11369781)Curated
Sequence conflicti12142 – 121421M → T in AAK74120. (PubMed:11369781)Curated
Sequence conflicti12226 – 122261A → T in AAK74120. (PubMed:11369781)Curated
Sequence conflicti12582 – 125821L → V in AAK74120. (PubMed:11369781)Curated
Sequence conflicti12629 – 126291L → V in AAK74120. (PubMed:11369781)Curated
Sequence conflicti12695 – 126951A → SAT in AAK74120. (PubMed:11369781)Curated
Sequence conflicti12713 – 127131Q → K in AAK74120. (PubMed:11369781)Curated
Sequence conflicti12720 – 127201H → C in AAK74120. (PubMed:11369781)Curated
Sequence conflicti12735 – 127351G → S in AAK74120. (PubMed:11369781)Curated
Sequence conflicti12744 – 12899156Missing in AAK74120. (PubMed:11369781)CuratedAdd
BLAST
Sequence conflicti13352 – 133521T → A in AAK74120. (PubMed:11369781)Curated
Sequence conflicti13519 – 149241406Missing in AAK74120. (PubMed:11369781)CuratedAdd
BLAST
Sequence conflicti15053 – 150531D → N in AAK74120. (PubMed:11369781)Curated
Sequence conflicti15215 – 205155301Missing in AAK74120. (PubMed:11369781)CuratedAdd
BLAST
Sequence conflicti20515 – 205151V → E in BAC87568. (PubMed:14702039)Curated
Sequence conflicti20760 – 21071312Missing in BAC87568. (PubMed:14702039)CuratedAdd
BLAST
Sequence conflicti20839 – 208391T → I in AAK74120. (PubMed:11369781)Curated
Sequence conflicti20842 – 208421R → S in AAK74120. (PubMed:11369781)Curated
Sequence conflicti20977 – 209771T → I in AAK74120. (PubMed:11369781)Curated
Sequence conflicti21384 – 213841H → P in AAK74120. (PubMed:11369781)Curated
Sequence conflicti21384 – 213841H → P in BAC87568. (PubMed:14702039)Curated
Sequence conflicti21487 – 214871S → C in AAK74120. (PubMed:11369781)Curated
Sequence conflicti21487 – 214871S → C in BAC87568. (PubMed:14702039)Curated
Sequence conflicti21602 – 216021K → Q in AAK74120. (PubMed:11369781)Curated
Sequence conflicti21602 – 216021K → Q in BAC87568. (PubMed:14702039)Curated
Sequence conflicti21686 – 2169510YNEPGLDEPP → HHTLQRQSTT in AAK74120. (PubMed:11369781)Curated
Sequence conflicti21691 – 216911L → P in AAK74120. (PubMed:11369781)Curated

Polymorphismi

The number of repeats is highly polymorphic.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti545 – 5451T → A.
Corresponds to variant rs17000957 [ dbSNP | Ensembl ].
VAR_056592
Natural varianti1015 – 10151R → G.
Corresponds to variant rs17000950 [ dbSNP | Ensembl ].
VAR_056593
Natural varianti1032 – 10321S → T.
Corresponds to variant rs10411228 [ dbSNP | Ensembl ].
VAR_056594
Natural varianti1041 – 10411P → S.
Corresponds to variant rs10406202 [ dbSNP | Ensembl ].
VAR_056595
Natural varianti1162 – 11621T → I.
Corresponds to variant rs17000947 [ dbSNP | Ensembl ].
VAR_056596
Natural varianti1266 – 12661K → N.
Corresponds to variant rs1596797 [ dbSNP | Ensembl ].
VAR_056597
Natural varianti1353 – 13531H → Y.
Corresponds to variant rs12611293 [ dbSNP | Ensembl ].
VAR_056598
Natural varianti1400 – 14001K → N.
Corresponds to variant rs1596798 [ dbSNP | Ensembl ].
VAR_056599
Natural varianti1833 – 18331L → F.
Corresponds to variant rs4520945 [ dbSNP | Ensembl ].
VAR_056600
Natural varianti1953 – 19531S → P.
Corresponds to variant rs1108380 [ dbSNP | Ensembl ].
VAR_056601
Natural varianti2058 – 20581S → P.
Corresponds to variant rs1574479 [ dbSNP | Ensembl ].
VAR_056602
Natural varianti2150 – 21501I → V.
Corresponds to variant rs10407633 [ dbSNP | Ensembl ].
VAR_056603
Natural varianti2271 – 22711T → A.
Corresponds to variant rs11085805 [ dbSNP | Ensembl ].
VAR_056604
Natural varianti2288 – 22881V → L.
Corresponds to variant rs10410933 [ dbSNP | Ensembl ].
VAR_056605
Natural varianti2356 – 23561D → E.
Corresponds to variant rs10416013 [ dbSNP | Ensembl ].
VAR_056606
Natural varianti2747 – 27471A → T.
Corresponds to variant rs10402538 [ dbSNP | Ensembl ].
VAR_056607
Natural varianti2786 – 27861M → I.
Corresponds to variant rs17000886 [ dbSNP | Ensembl ].
VAR_056608
Natural varianti2834 – 28341T → M.
Corresponds to variant rs10407623 [ dbSNP | Ensembl ].
VAR_056609
Natural varianti3574 – 35741R → H.
Corresponds to variant rs2591594 [ dbSNP | Ensembl ].
VAR_056610
Natural varianti5743 – 57431H → D.
Corresponds to variant rs1559172 [ dbSNP | Ensembl ].
VAR_056611
Natural varianti5756 – 57561A → T.
Corresponds to variant rs1559171 [ dbSNP | Ensembl ].
VAR_056612
Natural varianti5854 – 58541F → V.
Corresponds to variant rs1862460 [ dbSNP | Ensembl ].
VAR_056613
Natural varianti7065 – 70651T → A.
Corresponds to variant rs17000770 [ dbSNP | Ensembl ].
VAR_056614
Natural varianti7274 – 72741I → V.
Corresponds to variant rs1867691 [ dbSNP | Ensembl ].
VAR_056615
Natural varianti10509 – 105091T → N.
Corresponds to variant rs11670461 [ dbSNP | Ensembl ].
VAR_056616

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF414442 mRNA. Translation: AAL65133.2.
AF361486 mRNA. Translation: AAK74120.3.
AK128681 mRNA. Translation: BAC87568.1.
RefSeqiNP_078966.2. NM_024690.2.
UniGeneiHs.432676.

Genome annotation databases

GeneIDi94025.
KEGGihsa:94025.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Mucin database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF414442 mRNA. Translation: AAL65133.2 .
AF361486 mRNA. Translation: AAK74120.3 .
AK128681 mRNA. Translation: BAC87568.1 .
RefSeqi NP_078966.2. NM_024690.2.
UniGenei Hs.432676.

3D structure databases

ProteinModelPortali Q8WXI7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125094. 3 interactions.
STRINGi 9606.ENSP00000381008.

PTM databases

PhosphoSitei Q8WXI7.

Proteomic databases

MaxQBi Q8WXI7.
PaxDbi Q8WXI7.
PRIDEi Q8WXI7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 94025.
KEGGi hsa:94025.

Organism-specific databases

CTDi 94025.
GeneCardsi GC19M008960.
H-InvDB HIX0021715.
HGNCi HGNC:15582. MUC16.
HPAi CAB055172.
MIMi 606154. gene.
neXtProti NX_Q8WXI7.
PharmGKBi PA31314.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
KOi K16145.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSi MUC16. human.
GeneWikii CA-125.
GenomeRNAii 94025.
NextBioi 78314.
PROi Q8WXI7.
SOURCEi Search...

Gene expression databases

CleanExi HS_MUC16.
Genevestigatori Q8WXI7.

Family and domain databases

Gene3Di 3.30.70.960. 65 hits.
InterProi IPR028850. MUC16.
IPR000082. SEA_dom.
[Graphical view ]
PANTHERi PTHR14672. PTHR14672. 1 hit.
Pfami PF01390. SEA. 55 hits.
[Graphical view ]
SMARTi SM00200. SEA. 23 hits.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 65 hits.
PROSITEi PS50024. SEA. 65 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure."
    O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K.
    Tumor Biol. 23:154-169(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-10431, SEQUENCE REVISION TO N-TERMINUS, TISSUE SPECIFICITY, INDUCTION.
  2. "The CA 125 gene: an extracellular superstructure dominated by repeat sequences."
    O'Brien T.J., Beard J.B., Underwood L.J., Dennis R.A., Santin A.D., York L.
    Tumor Biol. 22:348-366(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10432-22152.
  3. "Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16."
    Yin B.W.T., Lloyd K.O.
    J. Biol. Chem. 276:27371-27375(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8297-22152, PROTEIN SEQUENCE OF 21360-21365 AND 21983-21995, TISSUE SPECIFICITY.
  4. Lloyd K.O., Yin B.W.T.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20473-21695.
    Tissue: Uterus.
  6. "CA125 phosphorylation is associated with its secretion from the WISH human amnion cell line."
    Fendrick J.L., Konishi I., Geary S.M., Parmley T.H., Quirk J.G. Jr., O'Brien T.J.
    Tumor Biol. 18:278-289(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  7. "Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125."
    Kui Wong N., Easton R.L., Panico M., Sutton-Smith M., Morrison J.C., Lattanzio F.A., Morris H.R., Clark G.F., Dell A., Patankar M.S.
    J. Biol. Chem. 278:28619-28634(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION.
  8. "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion."
    Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., Miyajima A.
    J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MSLN.
  9. "Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer."
    McLemore M.R., Aouizerat B.
    Biol. Res. Nurs. 6:262-267(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, POLYMORPHISM.
  10. "Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye."
    Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K.
    Invest. Ophthalmol. Vis. Sci. 47:113-119(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiMUC16_HUMAN
AccessioniPrimary (citable) accession number: Q8WXI7
Secondary accession number(s): Q6ZQW5, Q96RK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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