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Q8WXI7

- MUC16_HUMAN

UniProt

Q8WXI7 - MUC16_HUMAN

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Protein

Mucin-16

Gene
MUC16, CA125
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces By similarity.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. cellular protein metabolic process Source: Reactome
  3. O-glycan processing Source: Reactome
  4. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-16
Short name:
MUC-16
Alternative name(s):
Ovarian cancer-related tumor marker CA125
Short name:
CA-125
Ovarian carcinoma antigen CA125
Gene namesi
Name:MUC16
Synonyms:CA125
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:15582. MUC16.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Secretedextracellular space
Note: May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2209622096Extracellular Reviewed predictionAdd
BLAST
Transmembranei22097 – 2211721Helical; Reviewed predictionAdd
BLAST
Topological domaini22118 – 2215235Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: UniProt
  3. extrinsic component of membrane Source: UniProtKB
  4. Golgi lumen Source: Reactome
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2215222152Mucin-16PRO_0000259595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi434 – 4341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi787 – 7871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi930 – 9301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi957 – 9571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1375 – 13751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1633 – 16331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1840 – 18401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1877 – 18771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1890 – 18901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2345 – 23451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2375 – 23751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2737 – 27371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3086 – 30861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3179 – 31791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3502 – 35021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4222 – 42221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4500 – 45001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4608 – 46081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4615 – 46151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4626 – 46261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4863 – 48631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5098 – 50981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5133 – 51331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5230 – 52301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5322 – 53221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5396 – 53961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5472 – 54721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5691 – 56911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5865 – 58651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi6090 – 60901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi6734 – 67341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi6861 – 68611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi6963 – 69631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi8031 – 80311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi8057 – 80571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi8326 – 83261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi8620 – 86201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi8686 – 86861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi8915 – 89151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi9204 – 92041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi9495 – 94951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi9787 – 97871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi9920 – 99201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10077 – 100771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10175 – 101751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10512 – 105121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10702 – 107021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10751 – 107511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi11055 – 110551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi11226 – 112261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi11265 – 112651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi11369 – 113691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi11596 – 115961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12081 – 120811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12102 – 121021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12118 – 121181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi12128 ↔ 12148 Reviewed prediction
Glycosylationi12170 – 121701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12237 – 122371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12274 – 122741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi12284 ↔ 12304 Reviewed prediction
Glycosylationi12395 – 123951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12416 – 124161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12432 – 124321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi12442 ↔ 12462 Reviewed prediction
Glycosylationi12551 – 125511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12572 – 125721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12588 – 125881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi12598 ↔ 12618 Reviewed prediction
Glycosylationi12706 – 127061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12727 – 127271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12743 – 127431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi12753 ↔ 12773 Reviewed prediction
Glycosylationi12826 – 128261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12862 – 128621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12883 – 128831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi12909 ↔ 12929 Reviewed prediction
Glycosylationi12982 – 129821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13018 – 130181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13039 – 130391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13055 – 130551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi13065 ↔ 13085 Reviewed prediction
Glycosylationi13174 – 131741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13195 – 131951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13211 – 132111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi13221 ↔ 13241 Reviewed prediction
Glycosylationi13330 – 133301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13351 – 133511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13367 – 133671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi13377 ↔ 13397 Reviewed prediction
Glycosylationi13423 – 134231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13486 – 134861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13507 – 135071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13523 – 135231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi13533 ↔ 13553 Reviewed prediction
Glycosylationi13579 – 135791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13642 – 136421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13663 – 136631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13679 – 136791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi13689 ↔ 13709 Reviewed prediction
Glycosylationi13798 – 137981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13819 – 138191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13835 – 138351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi13845 ↔ 13865 Reviewed prediction
Glycosylationi13954 – 139541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13975 – 139751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13991 – 139911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi14001 ↔ 14021 Reviewed prediction
Glycosylationi14110 – 141101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14131 – 141311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14147 – 141471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi14157 ↔ 14177 Reviewed prediction
Glycosylationi14266 – 142661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14287 – 142871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14303 – 143031N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi14313 ↔ 14333 Reviewed prediction
Glycosylationi14359 – 143591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14422 – 144221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14459 – 144591N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi14469 ↔ 14489 Reviewed prediction
Glycosylationi14580 – 145801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14601 – 146011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14617 – 146171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi14627 ↔ 14647 Reviewed prediction
Glycosylationi14736 – 147361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14757 – 147571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14773 – 147731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi14783 ↔ 14803 Reviewed prediction
Glycosylationi14825 – 148251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14892 – 148921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14913 – 149131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14929 – 149291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi14939 ↔ 14959 Reviewed prediction
Glycosylationi15048 – 150481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15069 – 150691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi15095 ↔ 15115 Reviewed prediction
Glycosylationi15204 – 152041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15241 – 152411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi15251 ↔ 15271 Reviewed prediction
Glycosylationi15360 – 153601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15381 – 153811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15397 – 153971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi15407 ↔ 15427 Reviewed prediction
Glycosylationi15516 – 155161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15537 – 155371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi15563 ↔ 15583 Reviewed prediction
Glycosylationi15672 – 156721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15693 – 156931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15709 – 157091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi15719 ↔ 15739 Reviewed prediction
Glycosylationi15827 – 158271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15848 – 158481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15864 – 158641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi15874 ↔ 15894 Reviewed prediction
Glycosylationi15947 – 159471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15983 – 159831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16004 – 160041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16020 – 160201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16138 – 161381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16159 – 161591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16175 – 161751N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi16185 ↔ 16205 Reviewed prediction
Glycosylationi16258 – 162581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16294 – 162941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16315 – 163151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16331 – 163311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi16341 ↔ 16361 Reviewed prediction
Glycosylationi16450 – 164501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16471 – 164711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16487 – 164871N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi16497 ↔ 16517 Reviewed prediction
Glycosylationi16539 – 165391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16606 – 166061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16627 – 166271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16643 – 166431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi16653 ↔ 16673 Reviewed prediction
Glycosylationi16762 – 167621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16783 – 167831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16799 – 167991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi16809 ↔ 16829 Reviewed prediction
Glycosylationi16918 – 169181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16939 – 169391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16955 – 169551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi16965 ↔ 16985 Reviewed prediction
Glycosylationi17074 – 170741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17095 – 170951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17111 – 171111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi17121 ↔ 17141 Reviewed prediction
Glycosylationi17230 – 172301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17251 – 172511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi17277 ↔ 17297 Reviewed prediction
Glycosylationi17386 – 173861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17407 – 174071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17423 – 174231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi17433 ↔ 17453 Reviewed prediction
Glycosylationi17542 – 175421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17563 – 175631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17579 – 175791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi17589 ↔ 17609 Reviewed prediction
Glycosylationi17698 – 176981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17719 – 177191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi17745 ↔ 17765 Reviewed prediction
Glycosylationi17854 – 178541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17875 – 178751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17891 – 178911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18010 – 180101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18031 – 180311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18047 – 180471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi18057 ↔ 18077 Reviewed prediction
Glycosylationi18166 – 181661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18187 – 181871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18203 – 182031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18322 – 183221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18343 – 183431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18359 – 183591N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi18369 ↔ 18389 Reviewed prediction
Glycosylationi18478 – 184781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18499 – 184991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18515 – 185151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18634 – 186341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18655 – 186551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi18681 ↔ 18701 Reviewed prediction
Glycosylationi18790 – 187901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18811 – 188111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18827 – 188271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18946 – 189461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18967 – 189671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18983 – 189831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi18993 ↔ 19013 Reviewed prediction
Glycosylationi19039 – 190391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19102 – 191021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19123 – 191231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19139 – 191391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19258 – 192581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19279 – 192791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19295 – 192951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi19305 ↔ 19325 Reviewed prediction
Glycosylationi19414 – 194141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19435 – 194351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19451 – 194511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19570 – 195701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19591 – 195911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19607 – 196071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi19617 ↔ 19637 Reviewed prediction
Glycosylationi19726 – 197261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19747 – 197471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19763 – 197631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19881 – 198811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19902 – 199021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19918 – 199181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi19928 ↔ 19948 Reviewed prediction
Glycosylationi20037 – 200371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20058 – 200581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20074 – 200741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20157 – 201571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20193 – 201931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20214 – 202141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20230 – 202301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20349 – 203491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20370 – 203701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi20396 ↔ 20416 Reviewed prediction
Glycosylationi20505 – 205051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20526 – 205261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi20552 ↔ 20572 Reviewed prediction
Glycosylationi20661 – 206611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20682 – 206821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20698 – 206981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi20708 ↔ 20728 Reviewed prediction
Glycosylationi20817 – 208171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20838 – 208381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi20864 ↔ 20884 Reviewed prediction
Glycosylationi20973 – 209731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20994 – 209941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21010 – 210101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi21020 ↔ 21040 Reviewed prediction
Glycosylationi21129 – 211291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21150 – 211501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21166 – 211661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi21176 ↔ 21196 Reviewed prediction
Glycosylationi21285 – 212851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21306 – 213061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi21332 ↔ 21352 Reviewed prediction
Glycosylationi21378 – 213781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21389 – 213891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21441 – 214411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21461 – 214611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21477 – 214771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21574 – 215741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21595 – 215951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi21621 ↔ 21641 Reviewed prediction
Glycosylationi21725 – 217251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21745 – 217451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi21771 ↔ 21791 Reviewed prediction
Glycosylationi21840 – 218401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21857 – 218571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21899 – 218991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21932 – 219321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21971 – 219711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi22008 – 220081N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi22018 ↔ 22038 Reviewed prediction
Glycosylationi22062 – 220621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi22068 – 220681N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.1 Publication
Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.1 Publication
May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.1 Publication
May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8WXI7.
PaxDbiQ8WXI7.
PRIDEiQ8WXI7.

PTM databases

PhosphoSiteiQ8WXI7.

Expressioni

Tissue specificityi

Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.3 Publications

Inductioni

Up-regulated in ovarian cancer cells.1 Publication

Gene expression databases

CleanExiHS_MUC16.
GenevestigatoriQ8WXI7.

Organism-specific databases

HPAiCAB055172.

Interactioni

Subunit structurei

Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.1 Publication

Protein-protein interaction databases

BioGridi125094. 3 interactions.
STRINGi9606.ENSP00000381008.

Structurei

3D structure databases

ProteinModelPortaliQ8WXI7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12070 – 12190121SEA 1Add
BLAST
Domaini12229 – 12339111SEA 2Add
BLAST
Domaini12386 – 12504119SEA 3Add
BLAST
Domaini12539 – 12660122SEA 4Add
BLAST
Domaini12697 – 12815119SEA 5Add
BLAST
Domaini12853 – 12971119SEA 6Add
BLAST
Domaini13009 – 13127119SEA 7Add
BLAST
Domaini13165 – 13283119SEA 8Add
BLAST
Domaini13315 – 13439125SEA 9Add
BLAST
Domaini13477 – 13595119SEA 10Add
BLAST
Domaini13633 – 13751119SEA 11Add
BLAST
Repeati13767 – 1380135ANK 1Add
BLAST
Domaini13789 – 13907119SEA 12Add
BLAST
Domaini13939 – 14063125SEA 13Add
BLAST
Domaini14101 – 14219119SEA 14Add
BLAST
Domaini14251 – 14375125SEA 15Add
BLAST
Domaini14410 – 14531122SEA 16Add
BLAST
Domaini14567 – 14689123SEA 17Add
BLAST
Domaini14723 – 14845123SEA 18Add
BLAST
Domaini14877 – 15001125SEA 19Add
BLAST
Domaini15039 – 15157119SEA 20Add
BLAST
Domaini15195 – 15313119SEA 21Add
BLAST
Domaini15348 – 15469122SEA 22Add
BLAST
Domaini15507 – 15625119SEA 23Add
BLAST
Domaini15664 – 15774111SEA 24Add
BLAST
Domaini15812 – 15936125SEA 25Add
BLAST
Domaini16123 – 16247125SEA 26Add
BLAST
Domaini16279 – 16403125SEA 27Add
BLAST
Domaini16437 – 16559123SEA 28Add
BLAST
Domaini16591 – 16715125SEA 29Add
BLAST
Domaini16750 – 16871122SEA 30Add
BLAST
Domaini16905 – 17027123SEA 31Add
BLAST
Domaini17065 – 17183119SEA 32Add
BLAST
Domaini17221 – 17339119SEA 33Add
BLAST
Domaini17378 – 17488111SEA 34Add
BLAST
Domaini17534 – 17644111SEA 35Add
BLAST
Domaini17689 – 17807119SEA 36Add
BLAST
Domaini18001 – 18119119SEA 37Add
BLAST
Domaini18313 – 18431119SEA 38Add
BLAST
Domaini18625 – 18743119SEA 39Add
BLAST
Repeati18915 – 1894935ANK 2Add
BLAST
Domaini18937 – 19055119SEA 40Add
BLAST
Domaini19243 – 19367125SEA 41Add
BLAST
Domaini19555 – 19679125SEA 42Add
BLAST
Domaini19866 – 19990125SEA 43Add
BLAST
Domaini20184 – 20302119SEA 44Add
BLAST
Domaini20340 – 20458119SEA 45Add
BLAST
Domaini20496 – 20614119SEA 46Add
BLAST
Domaini20652 – 20770119SEA 47Add
BLAST
Domaini20804 – 20926123SEA 48Add
BLAST
Domaini20964 – 21082119SEA 49Add
BLAST
Domaini21117 – 21238122SEA 50Add
BLAST
Domaini21273 – 21394122SEA 51Add
BLAST
Domaini21433 – 21542110SEA 52Add
BLAST
Domaini21565 – 21683119SEA 53Add
BLAST
Domaini21717 – 21826110SEA 54Add
BLAST
Domaini21836 – 21957122SEA 55Add
BLAST
Domaini21959 – 22080122SEA 56Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 1208512072Thr-richAdd
BLAST
Compositional biasi1638 – 30551418Ser-richAdd
BLAST
Compositional biasi3961 – 4385425Ser-richAdd
BLAST
Compositional biasi7085 – 103953311Ser-richAdd
BLAST

Domaini

Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.

Sequence similaritiesi

Contains 2 ANK repeats.
Contains 56 SEA domains.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
KOiK16145.

Family and domain databases

Gene3Di3.30.70.960. 65 hits.
InterProiIPR028850. MUC16.
IPR000082. SEA_dom.
[Graphical view]
PANTHERiPTHR14672. PTHR14672. 1 hit.
PfamiPF01390. SEA. 55 hits.
[Graphical view]
SMARTiSM00200. SEA. 23 hits.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 65 hits.
PROSITEiPS50024. SEA. 65 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXI7-1 [UniParc]FASTAAdd to Basket

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MLKPSGLPGS SSPTRSLMTG SRSTKATPEM DSGLTGATLS PKTSTGAIVV      50
TEHTLPFTSP DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR 100
TSPSLSPQVN GTPSRNYPAT SMVSGLSSPR TRTSSTEGNF TKEASTYTLT 150
VETTSGPVTE KYTVPTETST TEGDSTETPW DTRYIPVKIT SPMKTFADST 200
ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL SPKGTPNSRG 250
ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI 300
FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL 350
GTPSISTKQT AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS 400
TSALTTTSPS TTLVSEETNT HHSTSGKETE GTLNTSMTPL ETSAPGEESE 450
MTATLVPTLG FTTLDSKIRS PSQVSSSHPT RELRTTGSTS GRQSSSTAAH 500
GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS PSMKTERPPA 550
STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT 600
HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS 650
VSPAVSKTAA GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP 700
LNTRHPFSSP EPDSAGHTKI STSIPLLSSA SVLEDKVSAT STFSHHKATS 750
SITTGTPEIS TKTKPSSAVL SSMTLSNAAT SPERVRNATS PLTHPSPSGE 800
ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL PSVSGVKTTF 850
SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT 900
MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ 950
TNRDTFNDSA APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK 1000
FTSPATSSME ATSIREPSTT ILTTETTNGP GSMAVASTNI PIGKGYITEG 1050
RLDTSHLPIG TTASSETSMD FTMAKESVSM SVSPSQSMDA AGSSTPGRTS 1100
QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS PDPGSARSTW 1150
LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS 1200
LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS 1250
IHLGAHASSE SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS 1300
SGSSPEMTAP GETNTGSTWD PTTYITTTDP KDTSSAQVST PHSVRTLRTT 1350
ENHPKTESAT PAAYSGSPKI SSSPNLTSPA TKAWTITDTT EHSTQLHYTK 1400
LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG EPLVLAPSEQ 1450
TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS 1500
KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH 1550
STQAQDTLSA TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS 1600
SEATTFWKPS TDTLSREIET GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL 1650
PIGTSSPAET STNMALERRS STATVSMAGT MGLLVTSAPG RSISQSLGRV 1700
SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA EGSQMSTSIP 1750
LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL 1800
GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG 1850
VHTSSAGTLA TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTDTE 1900
KSEVSSSIHP RPETSAPGAE TTLTSTPGNR AISLTLPFSS IPVEEVISTG 1950
ITSGPDINSA PMTHSPITPP TIVWTSTGTI EQSTQPLHAV SSEKVSVQTQ 2000
STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS TISRRNAITS 2050
WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA 2100
AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI 2150
TSRSDVSGLT SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP 2200
WTVSIPLGSH PTTNTETSIP VNSAGPPGLS TVASDVIDTP SDGAESIPTV 2250
SFSPSPDTEV TTISHFPEKT THSFRTISSL THELTSRVTP IPGDWMSSAM 2300
STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST VSLDNETTVK 2350
TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT 2400
ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL 2450
PPFTITHPVE TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP 2500
APGTWASVGS TTDLPAMGFL KTSPAGEAHS LLASTIEPAT AFTPHLSAAV 2550
VTGSSATSEA SLLTTSESKA IHSSPQTPTT PTSGANWETS ATPESLLVVT 2600
ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF PTLLPDTPAI 2650
PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK 2700
TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST 2750
LPAGTTGSLV FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG 2800
IRSGSTHSTG TKTFSSLPLT MNPGEVTAMS EITTNRLTAT QSTAPKGIPV 2850
KPTSAESGLL TPVSASSSPS KAFASLTTAP PSTWGIPQST LTFEFSEVPS 2900
LDTKSASLPT PGQSLNTIPD SDASTASSSL SKSPEKNPRA RMMTSTKAIS 2950
ASSFQSTGFT ETPEGSASPS MAGHEPRVPT SGTGDPRYAS ESMSYPDPSK 3000
ASSAMTSTSL ASKLTTLFST GQAARSGSSS SPISLSTEKE TSFLSPTAST 3050
SRKTSLFLGP SMARQPNILV HLQTSALTLS PTSTLNMSQE EPPELTSSQT 3100
IAEEEGTTAE TQTLTFTPSE TPTSLLPVSS PTEPTARRKS SPETWASSIS 3150
VPAKTSLVET TDGTLVTTIK MSSQAAQGNS TWPAPAEETG TSPAGTSPGS 3200
PEVSTTLKIM SSKEPSISPE IRSTVRNSPW KTPETTVPME TTVEPVTLQS 3250
TALGSGSTSI SHLPTGTTSP TKSPTENMLA TERVSLSPSP PEAWTNLYSG 3300
TPGGTRQSLA TMSSVSLESP TARSITGTGQ QSSPELVSKT TGMEFSMWHG 3350
STGGTTGDTH VSLSTSSNIL EDPVTSPNSV SSLTDKSKHK TETWVSTTAI 3400
PSTVLNNKIM AAEQQTSRSV DEAYSSTSSW SDQTSGSDIT LGASPDVTNT 3450
LYITSTAQTT SLVSLPSGDQ GITSLTNPSG GKTSSASSVT SPSIGLETLR 3500
ANVSAVKSDI APTAGHLSQT SSPAEVSILD VTTAPTPGIS TTITTMGTNS 3550
ISTTTPNPEV GMSTMDSTPA TERRTTSTEH PSTWSSTAAS DSWTVTDMTS 3600
NLKVARSPGT ISTMHTTSFL ASSTELDSMS TPHGRITVIG TSLVTPSSDA 3650
SAVKTETSTS ERTLSPSDTT ASTPISTFSR VQRMSISVPD ILSTSWTPSS 3700
TEAEDVPVSM VSTDHASTKT DPNTPLSTFL FDSLSTLDWD TGRSLSSATA 3750
TTSAPQGATT PQELTLETMI SPATSQLPFS IGHITSAVTP AAMARSSGVT 3800
FSRPDPTSKK AEQTSTQLPT TTSAHPGQVP RSAATTLDVI PHTAKTPDAT 3850
FQRQGQTALT TEARATSDSW NEKEKSTPSA PWITEMMNSV SEDTIKEVTS 3900
SSSVLKDPEY AGHKLGIWDD FIPKFGKAAH MRELPLLSPP QDKEAIHPST 3950
NTVETTGWVT SSEHASHSTI PAHSASSKLT SPVVTTSTRE QAIVSMSTTT 4000
WPESTRARTE PNSFLTIELR DVSPYMDTSS TTQTSIISSP GSTAITKGPR 4050
TEITSSKRIS SSFLAQSMRS SDSPSEAITR LSNFPAMTES GGMILAMQTS 4100
PPGATSLSAP TLDTSATASW TGTPLATTQR FTYSEKTTLF SKGPEDTSQP 4150
SPPSVEETSS SSSLVPIHAT TSPSNILLTS QGHSPSSTPP VTSVFLSETS 4200
GLGKTTDMSR ISLEPGTSLP PNLSSTAGEA LSTYEASRDT KAIHHSADTA 4250
VTNMEATSSE YSPIPGHTKP SKATSPLVTS HIMGDITSST SVFGSSETTE 4300
IETVSSVNQG LQERSTSQVA SSATETSTVI THVSSGDATT HVTKTQATFS 4350
SGTSISSPHQ FITSTNTFTD VSTNPSTSLI MTESSGVTIT TQTGPTGAAT 4400
QGPYLLDTST MPYLTETPLA VTPDFMQSEK TTLISKGPKD VTWTSPPSVA 4450
ETSYPSSLTP FLVTTIPPAT STLQGQHTSS PVSATSVLTS GLVKTTDMLN 4500
TSMEPVTNSP QNLNNPSNEI LATLAATTDI ETIHPSINKA VTNMGTASSA 4550
HVLHSTLPVS SEPSTATSPM VPASSMGDAL ASISIPGSET TDIEGEPTSS 4600
LTAGRKENST LQEMNSTTES NIILSNVSVG AITEATKMEV PSFDATFIPT 4650
PAQSTKFPDI FSVASSRLSN SPPMTISTHM TTTQTGSSGA TSKIPLALDT 4700
STLETSAGTP SVVTEGFAHS KITTAMNNDV KDVSQTNPPF QDEASSPSSQ 4750
APVLVTTLPS SVAFTPQWHS TSSPVSMSSV LTSSLVKTAG KVDTSLETVT 4800
SSPQSMSNTL DDISVTSAAT TDIETTHPSI NTVVTNVGTT GSAFESHSTV 4850
SAYPEPSKVT SPNVTTSTME DTTISRSIPK SSKTTRTETE TTSSLTPKLR 4900
ETSISQEITS STETSTVPYK ELTGATTEVS RTDVTSSSST SFPGPDQSTV 4950
SLDISTETNT RLSTSPIMTE SAEITITTQT GPHGATSQDT FTMDPSNTTP 5000
QAGIHSAMTH GFSQLDVTTL MSRIPQDVSW TSPPSVDKTS SPSSFLSSPA 5050
MTTPSLISST LPEDKLSSPM TSLLTSGLVK ITDILRTRLE PVTSSLPNFS 5100
STSDKILATS KDSKDTKEIF PSINTEETNV KANNSGHESH SPALADSETP 5150
KATTQMVITT TVGDPAPSTS MPVHGSSETT NIKREPTYFL TPRLRETSTS 5200
QESSFPTDTS FLLSKVPTGT ITEVSSTGVN SSSKISTPDH DKSTVPPDTF 5250
TGEIPRVFTS SIKTKSAEMT ITTQASPPES ASHSTLPLDT STTLSQGGTH 5300
STVTQGFPYS EVTTLMGMGP GNVSWMTTPP VEETSSVSSL MSSPAMTSPS 5350
PVSSTSPQSI PSSPLPVTAL PTSVLVTTTD VLGTTSPESV TSSPPNLSSI 5400
THERPATYKD TAHTEAAMHH STNTAVTNVG TSGSGHKSQS SVLADSETSK 5450
ATPLMSTTST LGDTSVSTST PNISQTNQIQ TEPTASLSPR LRESSTSEKT 5500
SSTTETNTAF SYVPTGAITQ ASRTEISSSR TSISDLDRPT IAPDISTGMI 5550
TRLFTSPIMT KSAEMTVTTQ TTTPGATSQG ILPWDTSTTL FQGGTHSTVS 5600
QGFPHSEITT LRSRTPGDVS WMTTPPVEET SSGFSLMSPS MTSPSPVSST 5650
SPESIPSSPL PVTALLTSVL VTTTNVLGTT SPETVTSSPP NLSSPTQERL 5700
TTYKDTAHTE AMHASMHTNT AVANVGTSIS GHESQSSVPA DSHTSKATSP 5750
MGITFAMGDT SVSTSTPAFF ETRIQTESTS SLIPGLRDTR TSEEINTVTE 5800
TSTVLSEVPT TTTTEVSRTE VITSSRTTIS GPDHSKMSPY ISTETITRLS 5850
TFPFVTGSTE MAITNQTGPI GTISQATLTL DTSSTASWEG THSPVTQRFP 5900
HSEETTTMSR STKGVSWQSP PSVEETSSPS SPVPLPAITS HSSLYSAVSG 5950
SSPTSALPVT SLLTSGRRKT IDMLDTHSEL VTSSLPSASS FSGEILTSEA 6000
STNTETIHFS ENTAETNMGT TNSMHKLHSS VSIHSQPSGH TPPKVTGSMM 6050
EDAIVSTSTP GSPETKNVDR DSTSPLTPEL KEDSTALVMN STTESNTVFS 6100
SVSLDAATEV SRAEVTYYDP TFMPASAQST KSPDISPEAS SSHSNSPPLT 6150
ISTHKTIATQ TGPSGVTSLG QLTLDTSTIA TSAGTPSART QDFVDSETTS 6200
VMNNDLNDVL KTSPFSAEEA NSLSSQAPLL VTTSPSPVTS TLQEHSTSSL 6250
VSVTSVPTPT LAKITDMDTN LEPVTRSPQN LRNTLATSEA TTDTHTMHPS 6300
INTAMANVGT TSSPNEFYFT VSPDSDPYKA TSAVVITSTS GDSIVSTSMP 6350
RSSAMKKIES ETTFSLIFRL RETSTSQKIG SSSDTSTVFD KAFTAATTEV 6400
SRTELTSSSR TSIQGTEKPT MSPDTSTRSV TMLSTFAGLT KSEERTIATQ 6450
TGPHRATSQG TLTWDTSITT SQAGTHSAMT HGFSQLDLST LTSRVPEYIS 6500
GTSPPSVEKT SSSSSLLSLP AITSPSPVPT TLPESRPSSP VHLTSLPTSG 6550
LVKTTDMLAS VASLPPNLGS TSHKIPTTSE DIKDTEKMYP STNIAVTNVG 6600
TTTSEKESYS SVPAYSEPPK VTSPMVTSFN IRDTIVSTSM PGSSEITRIE 6650
MESTFSVAHG LKGTSTSQDP IVSTEKSAVL HKLTTGATET SRTEVASSRR 6700
TSIPGPDHST ESPDISTEVI PSLPISLGIT ESSNMTIITR TGPPLGSTSQ 6750
GTFTLDTPTT SSRAGTHSMA TQEFPHSEMT TVMNKDPEIL SWTIPPSIEK 6800
TSFSSSLMPS PAMTSPPVSS TLPKTIHTTP SPMTSLLTPS LVMTTDTLGT 6850
SPEPTTSSPP NLSSTSHVIL TTDEDTTAIE AMHPSTSTAA TNVETTCSGH 6900
GSQSSVLTDS EKTKATAPMD TTSTMGHTTV STSMSVSSET TKIKRESTYS 6950
LTPGLRETSI SQNASFSTDT SIVLSEVPTG TTAEVSRTEV TSSGRTSIPG 7000
PSQSTVLPEI STRTMTRLFA SPTMTESAEM TIPTQTGPSG STSQDTLTLD 7050
TSTTKSQAKT HSTLTQRFPH SEMTTLMSRG PGDMSWQSSP SLENPSSLPS 7100
LLSLPATTSP PPISSTLPVT ISSSPLPVTS LLTSSPVTTT DMLHTSPELV 7150
TSSPPKLSHT SDERLTTGKD TTNTEAVHPS TNTAASNVEI PSFGHESPSS 7200
ALADSETSKA TSPMFITSTQ EDTTVAISTP HFLETSRIQK ESISSLSPKL 7250
RETGSSVETS SAIETSAVLS EVSIGATTEI SRTEVTSSSR TSISGSAEST 7300
MLPEISTTRK IIKFPTSPIL AESSEMTIKT QTSPPGSTSE STFTLDTSTT 7350
PSLVITHSTM TQRLPHSEIT TLVSRGAGDV PRPSSLPVEE TSPPSSQLSL 7400
SAMISPSPVS STLPASSHSS SASVTSPLTP GQVKTTEVLD ASAEPETSSP 7450
PSLSSTSVEI LATSEVTTDT EKIHPFPNTA VTKVGTSSSG HESPSSVLPD 7500
SETTKATSAM GTISIMGDTS VSTLTPALSN TRKIQSEPAS SLTTRLRETS 7550
TSEETSLATE ANTVLSKVST GATTEVSRTE AISFSRTSMS GPEQSTMSQD 7600
ISIGTIPRIS ASSVLTESAK MTITTQTGPS ESTLESTLNL NTATTPSWVE 7650
THSIVIQGFP HPEMTTSMGR GPGGVSWPSP PFVKETSPPS SPLSLPAVTS 7700
PHPVSTTFLA HIPPSPLPVT SLLTSGPATT TDILGTSTEP GTSSSSSLST 7750
TSHERLTTYK DTAHTEAVHP STNTGGTNVA TTSSGYKSQS SVLADSSPMC 7800
TTSTMGDTSV LTSTPAFLET RRIQTELASS LTPGLRESSG SEGTSSGTKM 7850
STVLSKVPTG ATTEISKEDV TSIPGPAQST ISPDISTRTV SWFSTSPVMT 7900
ESAEITMNTH TSPLGATTQG TSTLATSSTT SLTMTHSTIS QGFSHSQMST 7950
LMRRGPEDVS WMSPPLLEKT RPSFSLMSSP ATTSPSPVSS TLPESISSSP 8000
LPVTSLLTSG LAKTTDMLHK SSEPVTNSPA NLSSTSVEIL ATSEVTTDTE 8050
KTHPSSNRTV TDVGTSSSGH ESTSFVLADS QTSKVTSPMV ITSTMEDTSV 8100
STSTPGFFET SRIQTEPTSS LTLGLRKTSS SEGTSLATEM STVLSGVPTG 8150
ATAEVSRTEV TSSSRTSISG FAQLTVSPET STETITRLPT SSIMTESAEM 8200
MIKTQTDPPG STPESTHTVD ISTTPNWVET HSTVTQRFSH SEMTTLVSRS 8250
PGDMLWPSQS SVEETSSASS LLSLPATTSP SPVSSTLVED FPSASLPVTS 8300
LLTPGLVITT DRMGISREPG TSSTSNLSST SHERLTTLED TVDTEDMQPS 8350
THTAVTNVRT SISGHESQSS VLSDSETPKA TSPMGTTYTM GETSVSISTS 8400
DFFETSRIQI EPTSSLTSGL RETSSSERIS SATEGSTVLS EVPSGATTEV 8450
SRTEVISSRG TSMSGPDQFT ISPDISTEAI TRLSTSPIMT ESAESAITIE 8500
TGSPGATSEG TLTLDTSTTT FWSGTHSTAS PGFSHSEMTT LMSRTPGDVP 8550
WPSLPSVEEA SSVSSSLSSP AMTSTSFFSA LPESISSSPH PVTALLTLGP 8600
VKTTDMLRTS SEPETSSPPN LSSTSAEILA TSEVTKDREK IHPSSNTPVV 8650
NVGTVIYKHL SPSSVLADLV TTKPTSPMAT TSTLGNTSVS TSTPAFPETM 8700
MTQPTSSLTS GLREISTSQE TSSATERSAS LSGMPTGATT KVSRTEALSL 8750
GRTSTPGPAQ STISPEISTE TITRISTPLT TTGSAEMTIT PKTGHSGASS 8800
QGTFTLDTSS RASWPGTHSA ATHRSPHSGM TTPMSRGPED VSWPSRPSVE 8850
KTSPPSSLVS LSAVTSPSPL YSTPSESSHS SPLRVTSLFT PVMMKTTDML 8900
DTSLEPVTTS PPSMNITSDE SLATSKATME TEAIQLSENT AVTQMGTISA 8950
RQEFYSSYPG LPEPSKVTSP VVTSSTIKDI VSTTIPASSE ITRIEMESTS 9000
TLTPTPRETS TSQEIHSATK PSTVPYKALT SATIEDSMTQ VMSSSRGPSP 9050
DQSTMSQDIS SEVITRLSTS PIKAESTEMT ITTQTGSPGA TSRGTLTLDT 9100
STTFMSGTHS TASQGFSHSQ MTALMSRTPG DVPWLSHPSV EEASSASFSL 9150
SSPVMTSSSP VSSTLPDSIH SSSLPVTSLL TSGLVKTTEL LGTSSEPETS 9200
SPPNLSSTSA EILATTEVTT DTEKLEMTNV VTSGYTHESP SSVLADSVTT 9250
KATSSMGITY PTGDTNVLTS TPAFSDTSRI QTKSKLSLTP GLMETSISEE 9300
TSSATEKSTV LSSVPTGATT EVSRTEAISS SRTSIPGPAQ STMSSDTSME 9350
TITRISTPLT RKESTDMAIT PKTGPSGATS QGTFTLDSSS TASWPGTHSA 9400
TTQRFPQSVV TTPMSRGPED VSWPSPLSVE KNSPPSSLVS SSSVTSPSPL 9450
YSTPSGSSHS SPVPVTSLFT SIMMKATDML DASLEPETTS APNMNITSDE 9500
SLATSKATTE TEAIHVFENT AASHVETTSA TEELYSSSPG FSEPTKVISP 9550
VVTSSSIRDN MVSTTMPGSS GITRIEIESM SSLTPGLRET RTSQDITSST 9600
ETSTVLYKMS SGATPEVSRT EVMPSSRTSI PGPAQSTMSL DISDEVVTRL 9650
STSPIMTESA EITITTQTGY SLATSQVTLP LGTSMTFLSG THSTMSQGLS 9700
HSEMTNLMSR GPESLSWTSP RFVETTRSSS SLTSLPLTTS LSPVSSTLLD 9750
SSPSSPLPVT SLILPGLVKT TEVLDTSSEP KTSSSPNLSS TSVEIPATSE 9800
IMTDTEKIHP SSNTAVAKVR TSSSVHESHS SVLADSETTI TIPSMGITSA 9850
VDDTTVFTSN PAFSETRRIP TEPTFSLTPG FRETSTSEET TSITETSAVL 9900
YGVPTSATTE VSMTEIMSSN RTHIPDSDQS TMSPDIITEV ITRLSSSSMM 9950
SESTQMTITT QKSSPGATAQ STLTLATTTA PLARTHSTVP PRFLHSEMTT 10000
LMSRSPENPS WKSSPFVEKT SSSSSLLSLP VTTSPSVSST LPQSIPSSSF 10050
SVTSLLTPGM VKTTDTSTEP GTSLSPNLSG TSVEILAASE VTTDTEKIHP 10100
SSSMAVTNVG TTSSGHELYS SVSIHSEPSK ATYPVGTPSS MAETSISTSM 10150
PANFETTGFE AEPFSHLTSG FRKTNMSLDT SSVTPTNTPS SPGSTHLLQS 10200
SKTDFTSSAK TSSPDWPPAS QYTEIPVDII TPFNASPSIT ESTGITSFPE 10250
SRFTMSVTES THHLSTDLLP SAETISTGTV MPSLSEAMTS FATTGVPRAI 10300
SGSGSPFSRT ESGPGDATLS TIAESLPSST PVPFSSSTFT TTDSSTIPAL 10350
HEITSSSATP YRVDTSLGTE SSTTEGRLVM VSTLDTSSQP GRTSSTPILD 10400
TRMTESVELG TVTSAYQVPS LSTRLTRTDG IMEHITKIPN EAAHRGTIRP 10450
VKGPQTSTSP ASPKGLHTGG TKRMETTTTA LKTTTTALKT TSRATLTTSV 10500
YTPTLGTLTP LNASRQMAST ILTEMMITTP YVFPDVPETT SSLATSLGAE 10550
TSTALPRTTP SVLNRESETT ASLVSRSGAE RSPVIQTLDV SSSEPDTTAS 10600
WVIHPAETIP TVSKTTPNFF HSELDTVSST ATSHGADVSS AIPTNISPSE 10650
LDALTPLVTI SGTDTSTTFP TLTKSPHETE TRTTWLTHPA ETSSTIPRTI 10700
PNFSHHESDA TPSIATSPGA ETSSAIPIMT VSPGAEDLVT SQVTSSGTDR 10750
NMTIPTLTLS PGEPKTIASL VTHPEAQTSS AIPTSTISPA VSRLVTSMVT 10800
SLAAKTSTTN RALTNSPGEP ATTVSLVTHP AQTSPTVPWT TSIFFHSKSD 10850
TTPSMTTSHG AESSSAVPTP TVSTEVPGVV TPLVTSSRAV ISTTIPILTL 10900
SPGEPETTPS MATSHGEEAS SAIPTPTVSP GVPGVVTSLV TSSRAVTSTT 10950
IPILTFSLGE PETTPSMATS HGTEAGSAVP TVLPEVPGMV TSLVASSRAV 11000
TSTTLPTLTL SPGEPETTPS MATSHGAEAS STVPTVSPEV PGVVTSLVTS 11050
SSGVNSTSIP TLILSPGELE TTPSMATSHG AEASSAVPTP TVSPGVSGVV 11100
TPLVTSSRAV TSTTIPILTL SSSEPETTPS MATSHGVEAS SAVLTVSPEV 11150
PGMVTSLVTS SRAVTSTTIP TLTISSDEPE TTTSLVTHSE AKMISAIPTL 11200
AVSPTVQGLV TSLVTSSGSE TSAFSNLTVA SSQPETIDSW VAHPGTEASS 11250
VVPTLTVSTG EPFTNISLVT HPAESSSTLP RTTSRFSHSE LDTMPSTVTS 11300
PEAESSSAIS TTISPGIPGV LTSLVTSSGR DISATFPTVP ESPHESEATA 11350
SWVTHPAVTS TTVPRTTPNY SHSEPDTTPS IATSPGAEAT SDFPTITVSP 11400
DVPDMVTSQV TSSGTDTSIT IPTLTLSSGE PETTTSFITY SETHTSSAIP 11450
TLPVSPGASK MLTSLVISSG TDSTTTFPTL TETPYEPETT AIQLIHPAET 11500
NTMVPKTTPK FSHSKSDTTL PVAITSPGPE ASSAVSTTTI SPDMSDLVTS 11550
LVPSSGTDTS TTFPTLSETP YEPETTVTWL THPAETSTTV SGTIPNFSHR 11600
GSDTAPSMVT SPGVDTRSGV PTTTIPPSIP GVVTSQVTSS ATDTSTAIPT 11650
LTPSPGEPET TASSATHPGT QTGFTVPIRT VPSSEPDTMA SWVTHPPQTS 11700
TPVSRTTSSF SHSSPDATPV MATSPRTEAS SAVLTTISPG APEMVTSQIT 11750
SSGAATSTTV PTLTHSPGMP ETTALLSTHP RTGTSKTFPA STVFPQVSET 11800
TASLTIRPGA ETSTALPTQT TSSLFTLLVT GTSRVDLSPT ASPGVSAKTA 11850
PLSTHPGTET STMIPTSTLS LGLLETTGLL ATSSSAETST STLTLTVSPA 11900
VSGLSSASIT TDKPQTVTSW NTETSPSVTS VGPPEFSRTV TGTTMTLIPS 11950
EMPTPPKTSH GEGVSPTTIL RTTMVEATNL ATTGSSPTVA KTTTTFNTLA 12000
GSLFTPLTTP GMSTLASESV TSRTSYNHRS WISTTSSYNR RYWTPATSTP 12050
VTSTFSPGIS TSSIPSSTAA TVPFMVPFTL NFTITNLQYE EDMRHPGSRK 12100
FNATERELQG LLKPLFRNSS LEYLYSGCRL ASLRPEKDSS AMAVDAICTH 12150
RPDPEDLGLD RERLYWELSN LTNGIQELGP YTLDRNSLYV NGFTHRSSMP 12200
TTSTPGTSTV DVGTSGTPSS SPSPTAAGPL LMPFTLNFTI TNLQYEEDMR 12250
RTGSRKFNTM ESVLQGLLKP LFKNTSVGPL YSGCRLTLLR PEKDGAATGV 12300
DAICTHRLDP KSPGLNREQL YWELSKLTND IEELGPYTLD RNSLYVNGFT 12350
HQSSVSTTST PGTSTVDLRT SGTPSSLSSP TIMAAGPLLV PFTLNFTITN 12400
LQYGEDMGHP GSRKFNTTER VLQGLLGPIF KNTSVGPLYS GCRLTSLRSE 12450
KDGAATGVDA ICIHHLDPKS PGLNRERLYW ELSQLTNGIK ELGPYTLDRN 12500
SLYVNGFTHR TSVPTTSTPG TSTVDLGTSG TPFSLPSPAT AGPLLVLFTL 12550
NFTITNLKYE EDMHRPGSRK FNTTERVLQT LLGPMFKNTS VGLLYSGCRL 12600
TLLRSEKDGA ATGVDAICTH RLDPKSPGLD REQLYWELSQ LTNGIKELGP 12650
YTLDRNSLYV NGFTHWIPVP TSSTPGTSTV DLGSGTPSSL PSPTAAGPLL 12700
VPFTLNFTIT NLQYEEDMHH PGSRKFNTTE RVLQGLLGPM FKNTSVGLLY 12750
SGCRLTLLRS EKDGAATGVD AICTHRLDPK SPGVDREQLY WELSQLTNGI 12800
KELGPYTLDR NSLYVNGFTH QTSAPNTSTP GTSTVDLGTS GTPSSLPSPT 12850
SAGPLLVPFT LNFTITNLQY EEDMRHPGSR KFNTTERVLQ GLLKPLFKST 12900
SVGPLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGV DREQLYWELS 12950
QLTNGIKELG PYTLDRNSLY VNGFTHQTSA PNTSTPGTST VDLGTSGTPS 13000
SLPSPTSAGP LLVPFTLNFT ITNLQYEEDM HHPGSRKFNT TERVLQGLLG 13050
PMFKNTSVGL LYSGCRLTLL RPEKNGAATG MDAICSHRLD PKSPGLNREQ 13100
LYWELSQLTH GIKELGPYTL DRNSLYVNGF THRSSVAPTS TPGTSTVDLG 13150
TSGTPSSLPS PTTAVPLLVP FTLNFTITNL QYGEDMRHPG SRKFNTTERV 13200
LQGLLGPLFK NSSVGPLYSG CRLISLRSEK DGAATGVDAI CTHHLNPQSP 13250
GLDREQLYWQ LSQMTNGIKE LGPYTLDRNS LYVNGFTHRS SGLTTSTPWT 13300
STVDLGTSGT PSPVPSPTTA GPLLVPFTLN FTITNLQYEE DMHRPGSRKF 13350
NTTERVLQGL LSPIFKNSSV GPLYSGCRLT SLRPEKDGAA TGMDAVCLYH 13400
PNPKRPGLDR EQLYWELSQL THNITELGPY SLDRDSLYVN GFTHQNSVPT 13450
TSTPGTSTVY WATTGTPSSF PGHTEPGPLL IPFTFNFTIT NLHYEENMQH 13500
PGSRKFNTTE RVLQGLLKPL FKNTSVGPLY SGCRLTSLRP EKDGAATGMD 13550
AVCLYHPNPK RPGLDREQLY WELSQLTHNI TELGPYSLDR DSLYVNGFTH 13600
QNSVPTTSTP GTSTVYWATT GTPSSFPGHT EPGPLLIPFT FNFTITNLHY 13650
EENMQHPGSR KFNTTERVLQ GLLKPLFKNT SVGPLYSGCR LTLLRPEKHE 13700
AATGVDTICT HRVDPIGPGL DRERLYWELS QLTNSITELG PYTLDRDSLY 13750
VNGFNPRSSV PTTSTPGTST VHLATSGTPS SLPGHTAPVP LLIPFTLNFT 13800
ITNLHYEENM QHPGSRKFNT TERVLQGLLK PLFKNTSVGP LYSGCRLTLL 13850
RPEKHEAATG VDTICTHRVD PIGPGLXXEX LYWELSXLTX XIXELGPYTL 13900
DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX XTSAGPLLVP 13950
FTLNFTITNL QYEEDMHHPG SRKFNTTERV LQGLLGPMFK NTSVGLLYSG 14000
CRLTLLRPEK NGAATGMDAI CSHRLDPKSP GLDREQLYWE LSQLTHGIKE 14050
LGPYTLDRNS LYVNGFTHRS SVAPTSTPGT STVDLGTSGT PSSLPSPTTA 14100
VPLLVPFTLN FTITNLQYGE DMRHPGSRKF NTTERVLQGL LGPLFKNSSV 14150
GPLYSGCRLI SLRSEKDGAA TGVDAICTHH LNPQSPGLDR EQLYWQLSQM 14200
TNGIKELGPY TLDRNSLYVN GFTHRSSGLT TSTPWTSTVD LGTSGTPSPV 14250
PSPTTAGPLL VPFTLNFTIT NLQYEEDMHR PGSRKFNATE RVLQGLLSPI 14300
FKNSSVGPLY SGCRLTSLRP EKDGAATGMD AVCLYHPNPK RPGLDREQLY 14350
WELSQLTHNI TELGPYSLDR DSLYVNGFTH QSSMTTTRTP DTSTMHLATS 14400
RTPASLSGPT TASPLLVLFT INCTITNLQY EEDMRRTGSR KFNTMESVLQ 14450
GLLKPLFKNT SVGPLYSGCR LTLLRPKKDG AATGVDAICT HRLDPKSPGL 14500
NREQLYWELS KLTNDIEELG PYTLDRNSLY VNGFTHQSSV STTSTPGTST 14550
VDLRTSGTPS SLSSPTIMXX XPLLXPFTXN XTITNLXXXX XMXXPGSRKF 14600
NTTERVLQGL LRPLFKNTSV SSLYSGCRLT LLRPEKDGAA TRVDAACTYR 14650
PDPKSPGLDR EQLYWELSQL THSITELGPY TLDRVSLYVN GFNPRSSVPT 14700
TSTPGTSTVH LATSGTPSSL PGHTXXXPLL XPFTXNXTIT NLXXXXXMXX 14750
PGSRKFNTTE RVLQGLLKPL FRNSSLEYLY SGCRLASLRP EKDSSAMAVD 14800
AICTHRPDPE DLGLDRERLY WELSNLTNGI QELGPYTLDR NSLYVNGFTH 14850
RSSGLTTSTP WTSTVDLGTS GTPSPVPSPT TAGPLLVPFT LNFTITNLQY 14900
EEDMHRPGSR RFNTTERVLQ GLLTPLFKNT SVGPLYSGCR LTLLRPEKQE 14950
AATGVDTICT HRVDPIGPGL DRERLYWELS QLTNSITELG PYTLDRDSLY 15000
VNGFNPWSSV PTTSTPGTST VHLATSGTPS SLPGHTAPVP LLIPFTLNFT 15050
ITDLHYEENM QHPGSRKFNT TERVLQGLLK PLFKSTSVGP LYSGCRLTLL 15100
RPEKHGAATG VDAICTLRLD PTGPGLDRER LYWELSQLTN SVTELGPYTL 15150
DRDSLYVNGF THRSSVPTTS IPGTSAVHLE TSGTPASLPG HTAPGPLLVP 15200
FTLNFTITNL QYEEDMRHPG SRKFSTTERV LQGLLKPLFK NTSVSSLYSG 15250
CRLTLLRPEK DGAATRVDAV CTHRPDPKSP GLDRERLYWK LSQLTHGITE 15300
LGPYTLDRHS LYVNGFTHQS SMTTTRTPDT STMHLATSRT PASLSGPTTA 15350
SPLLVLFTIN FTITNLRYEE NMHHPGSRKF NTTERVLQGL LRPVFKNTSV 15400
GPLYSGCRLT TLRPKKDGAA TKVDAICTYR PDPKSPGLDR EQLYWELSQL 15450
THSITELGPY TQDRDSLYVN GFTHRSSVPT TSIPGTSAVH LETSGTPASL 15500
PGHTAPGPLL VPFTLNFTIT NLQYEEDMRH PGSRKFNTTE RVLQGLLKPL 15550
FKSTSVGPLY SGCRLTLLRP EKRGAATGVD TICTHRLDPL NPGLDREQLY 15600
WELSKLTRGI IELGPYLLDR GSLYVNGFTH RTSVPTTSTP GTSTVDLGTS 15650
GTPFSLPSPA XXXPLLXPFT XNXTITNLXX XXXMXXPGSR KFNTTERVLQ 15700
TLLGPMFKNT SVGLLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGV 15750
DREQLYWELS QLTNGIKELG PYTLDRNSLY VNGFTHWIPV PTSSTPGTST 15800
VDLGSGTPSS LPSPTTAGPL LVPFTLNFTI TNLKYEEDMH CPGSRKFNTT 15850
ERVLQSLLGP MFKNTSVGPL YSGCRLTLLR SEKDGAATGV DAICTHRLDP 15900
KSPGVDREQL YWELSQLTNG IKELGPYTLD RNSLYVNGFT HQTSAPNTST 15950
PGTSTVDLGT SGTPSSLPSP TXXXPLLXPF TXNXTITNLX XXXXMXXPGS 16000
RKFNTTEXVL QGLLXPXFKN XSVGXLYSGC RLTXLRXEKX GAATGXDAIC 16050
XHXXXPKXPG LXXEXLYWEL SXLTXXIXEL GPYTLDRXSL YVNGFTHWIP 16100
VPTSSTPGTS TVDLGSGTPS SLPSPTTAGP LLVPFTLNFT ITNLKYEEDM 16150
HCPGSRKFNT TERVLQSLLG PMFKNTSVGP LYSGCRLTSL RSEKDGAATG 16200
VDAICTHRVD PKSPGVDREQ LYWELSQLTN GIKELGPYTL DRNSLYVNGF 16250
THQTSAPNTS TPGTSTVXXG TSGTPSSXPX XTSAGPLLVP FTLNFTITNL 16300
QYEEDMHHPG SRKFNTTERV LQGLLGPMFK NTSVGLLYSG CRLTLLRPEK 16350
NGATTGMDAI CTHRLDPKSP GLXXEXLYWE LSXLTXXIXE LGPYTLDRXS 16400
LYVNGFTHXX SXPTTSTPGT STVXXGTSGT PSSXPXXTXX XPLLXPFTXN 16450
XTITNLXXXX XMXXPGSRKF NTTERVLQGL LKPLFRNSSL EYLYSGCRLA 16500
SLRPEKDSSA MAVDAICTHR PDPEDLGLDR ERLYWELSNL TNGIQELGPY 16550
TLDRNSLYVN GFTHRSSMPT TSTPGTSTVD VGTSGTPSSS PSPTTAGPLL 16600
IPFTLNFTIT NLQYGEDMGH PGSRKFNTTE RVLQGLLGPI FKNTSVGPLY 16650
SGCRLTSLRS EKDGAATGVD AICIHHLDPK SPGLNRERLY WELSQLTNGI 16700
KELGPYTLDR NSLYVNGFTH RTSVPTTSTP GTSTVDLGTS GTPFSLPSPA 16750
TAGPLLVLFT LNFTITNLKY EEDMHRPGSR KFNTTERVLQ TLLGPMFKNT 16800
SVGLLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGL XXEXLYWELS 16850
XLTXXIXELG PYTLDRXSLY VNGFTHXXSX PTTSTPGTST VXXGTSGTPS 16900
SXPXXTXXXP LLXPFTXNXT ITNLXXXXXM XXPGSRKFNT TERVLQGLLR 16950
PVFKNTSVGP LYSGCRLTLL RPKKDGAATK VDAICTYRPD PKSPGLDREQ 17000
LYWELSQLTH SITELGPYTQ DRDSLYVNGF THRSSVPTTS IPGTSAVHLE 17050
TTGTPSSFPG HTEPGPLLIP FTFNFTITNL RYEENMQHPG SRKFNTTERV 17100
LQGLLTPLFK NTSVGPLYSG CRLTLLRPEK QEAATGVDTI CTHRVDPIGP 17150
GLDRERLYWE LSQLTNSITE LGPYTLDRDS LYVDGFNPWS SVPTTSTPGT 17200
STVHLATSGT PSPLPGHTAP VPLLIPFTLN FTITDLHYEE NMQHPGSRKF 17250
NTTERVLQGL LKPLFKSTSV GPLYSGCRLT LLRPEKHGAA TGVDAICTLR 17300
LDPTGPGLDR ERLYWELSQL TNSITELGPY TLDRDSLYVN GFNPWSSVPT 17350
TSTPGTSTVH LATSGTPSSL PGHTTAGPLL VPFTLNFTIT NLKYEEDMHC 17400
PGSRKFNTTE RVLQSLHGPM FKNTSVGPLY SGCRLTLLRS EKDGAATGVD 17450
AICTHRLDPK SPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH 17500
XXSXPTTSTP GTSTVXXGTS GTPSSXPXXT XXXPLLXPFT XNXTITNLXX 17550
XXXMXXPGSR KFNTTEXVLQ GLLXPXFKNX SVGXLYSGCR LTXLRXEKXG 17600
AATGXDAICX HXXXPKXPGL XXEXLYWELS XLTNSITELG PYTLDRDSLY 17650
VNGFTHRSSM PTTSIPGTSA VHLETSGTPA SLPGHTAPGP LLVPFTLNFT 17700
ITNLQYEEDM RHPGSRKFNT TERVLQGLLK PLFKSTSVGP LYSGCRLTLL 17750
RPEKRGAATG VDTICTHRLD PLNPGLXXEX LYWELSXLTX XIXELGPYTL 17800
DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX XTXXXPLLXP 17850
FTXNXTITNL XXXXXMXXPG SRKFNTTEXV LQGLLXPXFK NXSVGXLYSG 17900
CRLTXLRXEK XGAATGXDAI CXHXXXPKXP GLXXEXLYWE LSXLTXXIXE 17950
LGPYTLDRXS LYVNGFHPRS SVPTTSTPGT STVHLATSGT PSSLPGHTAP 18000
VPLLIPFTLN FTITNLHYEE NMQHPGSRKF NTTERVLQGL LGPMFKNTSV 18050
GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLXX EXLYWELSXL 18100
TXXIXELGPY TLDRXSLYVN GFTHXXSXPT TSTPGTSTVX XGTSGTPSSX 18150
PXXTXXXPLL XPFTXNXTIT NLXXXXXMXX PGSRKFNTTE XVLQGLLXPX 18200
FKNXSVGXLY SGCRLTXLRX EKXGAATGXD AICXHXXXPK XPGLXXEXLY 18250
WELSXLTXXI XELGPYTLDR XSLYVNGFTH QNSVPTTSTP GTSTVYWATT 18300
GTPSSFPGHT EPGPLLIPFT FNFTITNLHY EENMQHPGSR KFNTTERVLQ 18350
GLLTPLFKNT SVGPLYSGCR LTLLRPEKQE AATGVDTICT HRVDPIGPGL 18400
XXEXLYWELS XLTXXIXELG PYTLDRXSLY VNGFTHXXSX PTTSTPGTST 18450
VXXGTSGTPS SXPXXTXXXP LLXPFTXNXT ITNLXXXXXM XXPGSRKFNT 18500
TEXVLQGLLX PXFKNXSVGX LYSGCRLTXL RXEKXGAATG XDAICXHXXX 18550
PKXPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THRSSVPTTS 18600
SPGTSTVHLA TSGTPSSLPG HTAPVPLLIP FTLNFTITNL HYEENMQHPG 18650
SRKFNTTERV LQGLLKPLFK STSVGPLYSG CRLTLLRPEK HGAATGVDAI 18700
CTLRLDPTGP GLXXEXLYWE LSXLTXXIXE LGPYTLDRXS LYVNGFTHXX 18750
SXPTTSTPGT STVXXGTSGT PSSXPXXTXX XPLLXPFTXN XTITNLXXXX 18800
XMXXPGSRKF NTTEXVLQGL LXPXFKNXSV GXLYSGCRLT XLRXEKXGAA 18850
TGXDAICXHX XXPKXPGLXX EXLYWELSXL TXXIXELGPY TLDRXSLYVN 18900
GFTHRTSVPT TSTPGTSTVH LATSGTPSSL PGHTAPVPLL IPFTLNFTIT 18950
NLQYEEDMHR PGSRKFNTTE RVLQGLLSPI FKNSSVGPLY SGCRLTSLRP 19000
EKDGAATGMD AVCLYHPNPK RPGLDREQLY CELSQLTHNI TELGPYSLDR 19050
DSLYVNGFTH QNSVPTTSTP GTSTVYWATT GTPSSFPGHT XXXPLLXPFT 19100
XNXTITNLXX XXXMXXPGSR KFNTTEXVLQ GLLXPXFKNX SVGXLYSGCR 19150
LTXLRXEKXG AATGXDAICX HXXXPKXPGL XXEXLYWELS XLTXXIXELG 19200
PYTLDRXSLY VNGFTHWSSG LTTSTPWTST VDLGTSGTPS PVPSPTTAGP 19250
LLVPFTLNFT ITNLQYEEDM HRPGSRKFNA TERVLQGLLS PIFKNTSVGP 19300
LYSGCRLTLL RPEKQEAATG VDTICTHRVD PIGPGLXXEX LYWELSXLTX 19350
XIXELGPYTL DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX 19400
XTXXXPLLXP FTXNXTITNL XXXXXMXXPG SRKFNTTEXV LQGLLXPXFK 19450
NXSVGXLYSG CRLTXLRXEK XGAATGXDAI CXHXXXPKXP GLXXEXLYWE 19500
LSXLTXXIXE LGPYTLDRXS LYVNGFTHRS FGLTTSTPWT STVDLGTSGT 19550
PSPVPSPTTA GPLLVPFTLN FTITNLQYEE DMHRPGSRKF NTTERVLQGL 19600
LTPLFRNTSV SSLYSGCRLT LLRPEKDGAA TRVDAVCTHR PDPKSPGLXX 19650
EXLYWELSXL TXXIXELGPY TLDRXSLYVN GFTHXXSXPT TSTPGTSTVX 19700
XGTSGTPSSX PXXTXXXPLL XPFTXNXTIT NLXXXXXMXX PGSRKFNTTE 19750
XVLQGLLXPX FKNXSVGXLY SGCRLTXLRX EKXGAATGXD AICXHXXXPK 19800
XPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH WIPVPTSSTP 19850
GTSTVDLGSG TPSSLPSPTT AGPLLVPFTL NFTITNLQYG EDMGHPGSRK 19900
FNTTERVLQG LLGPIFKNTS VGPLYSGCRL TSLRSEKDGA ATGVDAICIH 19950
HLDPKSPGLX XEXLYWELSX LTXXIXELGP YTLDRXSLYV NGFTHXXSXP 20000
TTSTPGTSTV XXGTSGTPSS XPXXTXXXPL LXPFTXNXTI TNLXXXXXMX 20050
XPGSRKFNTT EXVLQGLLXP XFKNXSVGXL YSGCRLTXLR XEKXGAATGX 20100
DAICXHXXXP KXPGLXXEXL YWELSXLTXX IXELGPYTLD RXSLYVNGFT 20150
HQTFAPNTST PGTSTVDLGT SGTPSSLPSP TSAGPLLVPF TLNFTITNLQ 20200
YEEDMHHPGS RKFNTTERVL QGLLGPMFKN TSVGLLYSGC RLTLLRPEKN 20250
GAATRVDAVC THRPDPKSPG LXXEXLYWEL SXLTXXIXEL GPYTLDRXSL 20300
YVNGFTHXXS XPTTSTPGTS TVXXGTSGTP SSXPXXTAPV PLLIPFTLNF 20350
TITNLHYEEN MQHPGSRKFN TTERVLQGLL KPLFKSTSVG PLYSGCRLTL 20400
LRPEKHGAAT GVDAICTLRL DPTGPGLDRE RLYWELSQLT NSVTELGPYT 20450
LDRDSLYVNG FTQRSSVPTT SIPGTSAVHL ETSGTPASLP GHTAPGPLLV 20500
PFTLNFTITN LQYEVDMRHP GSRKFNTTER VLQGLLKPLF KSTSVGPLYS 20550
GCRLTLLRPE KRGAATGVDT ICTHRLDPLN PGLDREQLYW ELSKLTRGII 20600
ELGPYLLDRG SLYVNGFTHR NFVPITSTPG TSTVHLGTSE TPSSLPRPIV 20650
PGPLLVPFTL NFTITNLQYE EAMRHPGSRK FNTTERVLQG LLRPLFKNTS 20700
IGPLYSSCRL TLLRPEKDKA ATRVDAICTH HPDPQSPGLN REQLYWELSQ 20750
LTHGITELGP YTLDRDSLYV DGFTHWSPIP TTSTPGTSIV NLGTSGIPPS 20800
LPETTXXXPL LXPFTXNXTI TNLXXXXXMX XPGSRKFNTT ERVLQGLLKP 20850
LFKSTSVGPL YSGCRLTLLR PEKDGVATRV DAICTHRPDP KIPGLDRQQL 20900
YWELSQLTHS ITELGPYTLD RDSLYVNGFT QRSSVPTTST PGTFTVQPET 20950
SETPSSLPGP TATGPVLLPF TLNFTITNLQ YEEDMHRPGS RKFNTTERVL 21000
QGLLMPLFKN TSVSSLYSGC RLTLLRPEKD GAATRVDAVC THRPDPKSPG 21050
LDRERLYWKL SQLTHGITEL GPYTLDRHSL YVNGFTHQSS MTTTRTPDTS 21100
TMHLATSRTP ASLSGPTTAS PLLVLFTINF TITNLRYEEN MHHPGSRKFN 21150
TTERVLQGLL RPVFKNTSVG PLYSGCRLTL LRPKKDGAAT KVDAICTYRP 21200
DPKSPGLDRE QLYWELSQLT HSITELGPYT LDRDSLYVNG FTQRSSVPTT 21250
SIPGTPTVDL GTSGTPVSKP GPSAASPLLV LFTLNFTITN LRYEENMQHP 21300
GSRKFNTTER VLQGLLRSLF KSTSVGPLYS GCRLTLLRPE KDGTATGVDA 21350
ICTHHPDPKS PRLDREQLYW ELSQLTHNIT ELGHYALDND SLFVNGFTHR 21400
SSVSTTSTPG TPTVYLGASK TPASIFGPSA ASHLLILFTL NFTITNLRYE 21450
ENMWPGSRKF NTTERVLQGL LRPLFKNTSV GPLYSGSRLT LLRPEKDGEA 21500
TGVDAICTHR PDPTGPGLDR EQLYLELSQL THSITELGPY TLDRDSLYVN 21550
GFTHRSSVPT TSTGVVSEEP FTLNFTINNL RYMADMGQPG SLKFNITDNV 21600
MKHLLSPLFQ RSSLGARYTG CRVIALRSVK NGAETRVDLL CTYLQPLSGP 21650
GLPIKQVFHE LSQQTHGITR LGPYSLDKDS LYLNGYNEPG LDEPPTTPKP 21700
ATTFLPPLSE ATTAMGYHLK TLTLNFTISN LQYSPDMGKG SATFNSTEGV 21750
LQHLLRPLFQ KSSMGPFYLG CQLISLRPEK DGAATGVDTT CTYHPDPVGP 21800
GLDIQQLYWE LSQLTHGVTQ LGFYVLDRDS LFINGYAPQN LSIRGEYQIN 21850
FHIVNWNLSN PDPTSSEYIT LLRDIQDKVT TLYKGSQLHD TFRFCLVTNL 21900
TMDSVLVTVK ALFSSNLDPS LVEQVFLDKT LNASFHWLGS TYQLVDIHVT 21950
EMESSVYQPT SSSSTQHFYL NFTITNLPYS QDKAQPGTTN YQRNKRNIED 22000
ALNQLFRNSS IKSYFSDCQV STFRSVPNRH HTGVDSLCNF SPLARRVDRV 22050
AIYEEFLRMT RNGTQLQNFT LDRSSVLVDG YSPNRNEPLT GNSDLPFWAV 22100
ILIGLAGLLG LITCLICGVL VTTRRRKKEG EYNVQQQCPG YYQSHLDLED 22150
LQ 22152
Length:22,152
Mass (Da):2,353,428
Last modified:March 1, 2003 - v2
Checksum:iB3E7BDF19997A440
GO

Polymorphismi

The number of repeats is highly polymorphic.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti545 – 5451T → A.
Corresponds to variant rs17000957 [ dbSNP | Ensembl ].
VAR_056592
Natural varianti1015 – 10151R → G.
Corresponds to variant rs17000950 [ dbSNP | Ensembl ].
VAR_056593
Natural varianti1032 – 10321S → T.
Corresponds to variant rs10411228 [ dbSNP | Ensembl ].
VAR_056594
Natural varianti1041 – 10411P → S.
Corresponds to variant rs10406202 [ dbSNP | Ensembl ].
VAR_056595
Natural varianti1162 – 11621T → I.
Corresponds to variant rs17000947 [ dbSNP | Ensembl ].
VAR_056596
Natural varianti1266 – 12661K → N.
Corresponds to variant rs1596797 [ dbSNP | Ensembl ].
VAR_056597
Natural varianti1353 – 13531H → Y.
Corresponds to variant rs12611293 [ dbSNP | Ensembl ].
VAR_056598
Natural varianti1400 – 14001K → N.
Corresponds to variant rs1596798 [ dbSNP | Ensembl ].
VAR_056599
Natural varianti1833 – 18331L → F.
Corresponds to variant rs4520945 [ dbSNP | Ensembl ].
VAR_056600
Natural varianti1953 – 19531S → P.
Corresponds to variant rs1108380 [ dbSNP | Ensembl ].
VAR_056601
Natural varianti2058 – 20581S → P.
Corresponds to variant rs1574479 [ dbSNP | Ensembl ].
VAR_056602
Natural varianti2150 – 21501I → V.
Corresponds to variant rs10407633 [ dbSNP | Ensembl ].
VAR_056603
Natural varianti2271 – 22711T → A.
Corresponds to variant rs11085805 [ dbSNP | Ensembl ].
VAR_056604
Natural varianti2288 – 22881V → L.
Corresponds to variant rs10410933 [ dbSNP | Ensembl ].
VAR_056605
Natural varianti2356 – 23561D → E.
Corresponds to variant rs10416013 [ dbSNP | Ensembl ].
VAR_056606
Natural varianti2747 – 27471A → T.
Corresponds to variant rs10402538 [ dbSNP | Ensembl ].
VAR_056607
Natural varianti2786 – 27861M → I.
Corresponds to variant rs17000886 [ dbSNP | Ensembl ].
VAR_056608
Natural varianti2834 – 28341T → M.
Corresponds to variant rs10407623 [ dbSNP | Ensembl ].
VAR_056609
Natural varianti3574 – 35741R → H.
Corresponds to variant rs2591594 [ dbSNP | Ensembl ].
VAR_056610
Natural varianti5743 – 57431H → D.
Corresponds to variant rs1559172 [ dbSNP | Ensembl ].
VAR_056611
Natural varianti5756 – 57561A → T.
Corresponds to variant rs1559171 [ dbSNP | Ensembl ].
VAR_056612
Natural varianti5854 – 58541F → V.
Corresponds to variant rs1862460 [ dbSNP | Ensembl ].
VAR_056613
Natural varianti7065 – 70651T → A.
Corresponds to variant rs17000770 [ dbSNP | Ensembl ].
VAR_056614
Natural varianti7274 – 72741I → V.
Corresponds to variant rs1867691 [ dbSNP | Ensembl ].
VAR_056615
Natural varianti10509 – 105091T → N.
Corresponds to variant rs11670461 [ dbSNP | Ensembl ].
VAR_056616

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8346 – 83461D → A in AAK74120. 1 Publication
Sequence conflicti8580 – 85801A → T in AAK74120. 1 Publication
Sequence conflicti9061 – 90611S → T in AAK74120. 1 Publication
Sequence conflicti9074 – 90741A → T in AAK74120. 1 Publication
Sequence conflicti9131 – 91311D → E in AAK74120. 1 Publication
Sequence conflicti9407 – 94071Q → R in AAK74120. 1 Publication
Sequence conflicti9504 – 95041T → A in AAK74120. 1 Publication
Sequence conflicti9610 – 96101S → P in AAK74120. 1 Publication
Sequence conflicti9852 – 98521D → E in AAK74120. 1 Publication
Sequence conflicti9901 – 99011Y → F in AAK74120. 1 Publication
Sequence conflicti10171 – 101711F → L in AAK74120. 1 Publication
Sequence conflicti10396 – 103961T → S in AAK74120. 1 Publication
Sequence conflicti10515 – 105151R → M in AAK74120. 1 Publication
Sequence conflicti10522 – 105221L → P in AAK74120. 1 Publication
Sequence conflicti10563 – 105631L → F in AAK74120. 1 Publication
Sequence conflicti10830 – 108301P → S in AAK74120. 1 Publication
Sequence conflicti11156 – 111561S → F in AAK74120. 1 Publication
Sequence conflicti11201 – 112011A → G in AAK74120. 1 Publication
Sequence conflicti11457 – 114571G → D in AAK74120. 1 Publication
Sequence conflicti11506 – 115061K → R in AAK74120. 1 Publication
Sequence conflicti11577 – 115771V → A in AAK74120. 1 Publication
Sequence conflicti11783 – 117831G → E in AAK74120. 1 Publication
Sequence conflicti12142 – 121421M → T in AAK74120. 1 Publication
Sequence conflicti12226 – 122261A → T in AAK74120. 1 Publication
Sequence conflicti12582 – 125821L → V in AAK74120. 1 Publication
Sequence conflicti12629 – 126291L → V in AAK74120. 1 Publication
Sequence conflicti12695 – 126951A → SAT in AAK74120. 1 Publication
Sequence conflicti12713 – 127131Q → K in AAK74120. 1 Publication
Sequence conflicti12720 – 127201H → C in AAK74120. 1 Publication
Sequence conflicti12735 – 127351G → S in AAK74120. 1 Publication
Sequence conflicti12744 – 12899156Missing in AAK74120. 1 PublicationAdd
BLAST
Sequence conflicti13352 – 133521T → A in AAK74120. 1 Publication
Sequence conflicti13519 – 149241406Missing in AAK74120. 1 PublicationAdd
BLAST
Sequence conflicti15053 – 150531D → N in AAK74120. 1 Publication
Sequence conflicti15215 – 205155301Missing in AAK74120. 1 PublicationAdd
BLAST
Sequence conflicti20515 – 205151V → E in BAC87568. 1 Publication
Sequence conflicti20760 – 21071312Missing in BAC87568. 1 PublicationAdd
BLAST
Sequence conflicti20839 – 208391T → I in AAK74120. 1 Publication
Sequence conflicti20842 – 208421R → S in AAK74120. 1 Publication
Sequence conflicti20977 – 209771T → I in AAK74120. 1 Publication
Sequence conflicti21384 – 213841H → P in AAK74120. 1 Publication
Sequence conflicti21384 – 213841H → P in BAC87568. 1 Publication
Sequence conflicti21487 – 214871S → C in AAK74120. 1 Publication
Sequence conflicti21487 – 214871S → C in BAC87568. 1 Publication
Sequence conflicti21602 – 216021K → Q in AAK74120. 1 Publication
Sequence conflicti21602 – 216021K → Q in BAC87568. 1 Publication
Sequence conflicti21686 – 2169510YNEPGLDEPP → HHTLQRQSTT in AAK74120. 1 Publication
Sequence conflicti21691 – 216911L → P in AAK74120. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF414442 mRNA. Translation: AAL65133.2.
AF361486 mRNA. Translation: AAK74120.3.
AK128681 mRNA. Translation: BAC87568.1.
RefSeqiNP_078966.2. NM_024690.2.
UniGeneiHs.432676.

Genome annotation databases

GeneIDi94025.
KEGGihsa:94025.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Mucin database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF414442 mRNA. Translation: AAL65133.2 .
AF361486 mRNA. Translation: AAK74120.3 .
AK128681 mRNA. Translation: BAC87568.1 .
RefSeqi NP_078966.2. NM_024690.2.
UniGenei Hs.432676.

3D structure databases

ProteinModelPortali Q8WXI7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125094. 3 interactions.
STRINGi 9606.ENSP00000381008.

PTM databases

PhosphoSitei Q8WXI7.

Proteomic databases

MaxQBi Q8WXI7.
PaxDbi Q8WXI7.
PRIDEi Q8WXI7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 94025.
KEGGi hsa:94025.

Organism-specific databases

CTDi 94025.
GeneCardsi GC19M008960.
H-InvDB HIX0021715.
HGNCi HGNC:15582. MUC16.
HPAi CAB055172.
MIMi 606154. gene.
neXtProti NX_Q8WXI7.
PharmGKBi PA31314.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
KOi K16145.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSi MUC16. human.
GeneWikii CA-125.
GenomeRNAii 94025.
NextBioi 78314.
PROi Q8WXI7.
SOURCEi Search...

Gene expression databases

CleanExi HS_MUC16.
Genevestigatori Q8WXI7.

Family and domain databases

Gene3Di 3.30.70.960. 65 hits.
InterProi IPR028850. MUC16.
IPR000082. SEA_dom.
[Graphical view ]
PANTHERi PTHR14672. PTHR14672. 1 hit.
Pfami PF01390. SEA. 55 hits.
[Graphical view ]
SMARTi SM00200. SEA. 23 hits.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 65 hits.
PROSITEi PS50024. SEA. 65 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure."
    O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K.
    Tumor Biol. 23:154-169(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-10431, SEQUENCE REVISION TO N-TERMINUS, TISSUE SPECIFICITY, INDUCTION.
  2. "The CA 125 gene: an extracellular superstructure dominated by repeat sequences."
    O'Brien T.J., Beard J.B., Underwood L.J., Dennis R.A., Santin A.D., York L.
    Tumor Biol. 22:348-366(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10432-22152.
  3. "Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16."
    Yin B.W.T., Lloyd K.O.
    J. Biol. Chem. 276:27371-27375(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8297-22152, PROTEIN SEQUENCE OF 21360-21365 AND 21983-21995, TISSUE SPECIFICITY.
  4. Lloyd K.O., Yin B.W.T.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20473-21695.
    Tissue: Uterus.
  6. "CA125 phosphorylation is associated with its secretion from the WISH human amnion cell line."
    Fendrick J.L., Konishi I., Geary S.M., Parmley T.H., Quirk J.G. Jr., O'Brien T.J.
    Tumor Biol. 18:278-289(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  7. "Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125."
    Kui Wong N., Easton R.L., Panico M., Sutton-Smith M., Morrison J.C., Lattanzio F.A., Morris H.R., Clark G.F., Dell A., Patankar M.S.
    J. Biol. Chem. 278:28619-28634(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION.
  8. "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion."
    Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., Miyajima A.
    J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MSLN.
  9. "Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer."
    McLemore M.R., Aouizerat B.
    Biol. Res. Nurs. 6:262-267(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, POLYMORPHISM.
  10. "Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye."
    Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K.
    Invest. Ophthalmol. Vis. Sci. 47:113-119(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiMUC16_HUMAN
AccessioniPrimary (citable) accession number: Q8WXI7
Secondary accession number(s): Q6ZQW5, Q96RK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3