ID MUC16_HUMAN Reviewed; 22152 AA. AC Q8WXI7; Q6ZQW5; Q96RK2; DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 2. DT 31-OCT-2012, entry version 73. DE RecName: Full=Mucin-16; DE Short=MUC-16; DE AltName: Full=Ovarian cancer-related tumor marker CA125; DE Short=CA-125; DE AltName: Full=Ovarian carcinoma antigen CA125; GN Name=MUC16; Synonyms=CA125; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-10431, SEQUENCE REVISION TO RP N-TERMINUS, TISSUE SPECIFICITY, AND INDUCTION. RX PubMed=12218296; DOI=10.1159/000064032; RA O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K.; RT "The CA 125 gene: a newly discovered extension of the glycosylated N- RT terminal domain doubles the size of this extracellular RT superstructure."; RL Tumor Biol. 23:154-169(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 10432-22152. RX MEDLINE=21646939; PubMed=11786729; DOI=10.1159/000050638; RA O'Brien T.J., Beard J.B., Underwood L.J., Dennis R.A., Santin A.D., RA York L.; RT "The CA 125 gene: an extracellular superstructure dominated by repeat RT sequences."; RL Tumor Biol. 22:348-366(2001). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 8297-22152, PROTEIN SEQUENCE OF RP 21360-21365 AND 21983-21995, AND TISSUE SPECIFICITY. RX PubMed=11369781; DOI=10.1074/jbc.M103554200; RA Yin B.W.T., Lloyd K.O.; RT "Molecular cloning of the CA125 ovarian cancer antigen: identification RT as a new mucin, MUC16."; RL J. Biol. Chem. 276:27371-27375(2001). RN [4] RP SEQUENCE REVISION. RA Lloyd K.O., Yin B.W.T.; RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20473-21695. RC TISSUE=Uterus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP PHOSPHORYLATION. RX PubMed=9276028; RA Fendrick J.L., Konishi I., Geary S.M., Parmley T.H., Quirk J.G. Jr., RA O'Brien T.J.; RT "CA125 phosphorylation is associated with its secretion from the WISH RT human amnion cell line."; RL Tumor Biol. 18:278-289(1997). RN [7] RP GLYCOSYLATION. RX PubMed=12734200; DOI=10.1074/jbc.M302741200; RA Kui Wong N., Easton R.L., Panico M., Sutton-Smith M., Morrison J.C., RA Lattanzio F.A., Morris H.R., Clark G.F., Dell A., Patankar M.S.; RT "Characterization of the oligosaccharides associated with the human RT ovarian tumor marker CA125."; RL J. Biol. Chem. 278:28619-28634(2003). RN [8] RP INTERACTION WITH MSLN. RX PubMed=14676194; DOI=10.1074/jbc.M312372200; RA Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., RA Miyajima A.; RT "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates RT cell adhesion."; RL J. Biol. Chem. 279:9190-9198(2004). RN [9] RP REVIEW, AND POLYMORPHISM. RX PubMed=15788735; DOI=10.1177/1099800404274445; RA McLemore M.R., Aouizerat B.; RT "Introducing the MUC16 gene: implications for prevention and early RT detection in epithelial ovarian cancer."; RL Biol. Res. Nurs. 6:262-267(2005). RN [10] RP TISSUE SPECIFICITY. RX PubMed=16384952; DOI=10.1167/iovs.05-0735; RA Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K.; RT "Mucin characteristics of human corneal-limbal epithelial cells that RT exclude the rose bengal anionic dye."; RL Invest. Ophthalmol. Vis. Sci. 47:113-119(2006). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-955, AND MASS RP SPECTROMETRY. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). CC -!- FUNCTION: Thought to provide a protective, lubricating barrier CC against particles and infectious agents at mucosal surfaces (By CC similarity). CC -!- SUBUNIT: Binds to MSLN. Binding to MSLN mediates heterotypic cell CC adhesion. This may contribute to the metastasis of ovarian cancer CC to the peritoneum by initiating cell attachment to the mesothelial CC epithelium via binding to MSLN. CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane CC protein. Secreted, extracellular space. Note=May be liberated into CC the extracellular space following the phosphorylation of the CC intracellular C-terminus which induces the proteolytic cleavage CC and liberation of the extracellular domain. CC -!- TISSUE SPECIFICITY: Expressed in corneal and conjunctival CC epithelia (at protein level). Overexpressed in ovarian carcinomas CC and ovarian low malignant potential (LMP) tumors as compared to CC the expression in normal ovarian tissue and ovarian adenomas. CC -!- INDUCTION: Up-regulated in ovarian cancer cells. CC -!- DOMAIN: Composed of three domains, a Ser-, Thr-rich N-terminal CC domain, a repeated domain containing more than 60 partially CC conserved tandem repeats of 156 amino acids each (AAs 12061-21862) CC and a C-terminal transmembrane contain domain with a short CC cytoplasmic tail. CC -!- PTM: Heavily O-glycosylated; expresses both type 1 and type 2 core CC glycans. CC -!- PTM: Heavily N-glycosylated; expresses primarily high mannose and CC complex bisecting type N-linked glycans. CC -!- PTM: May be phosphorylated. Phosphorylation of the intracellular CC C-terminal domain may induce proteolytic cleavage and the CC liberation of the extracellular domain into the extracellular CC space. CC -!- PTM: May contain numerous disulfide bridges. Association of CC several molecules of the secreted form may occur through CC interchain disulfide bridges providing an extraordinarily large CC gel-like matrix in the extracellular space or in the lumen of CC secretory ducts. CC -!- POLYMORPHISM: The number of repeats is highly polymorphic. CC -!- MISCELLANEOUS: Antigen that is the basis for a widely used serum CC assay for the monitoring of patients with ovarian epithelial CC cancer. Due to lack of sensitivity for stage I disease and lack of CC specificity, it is of little value in the detection of early CC ovarian cancer. Due to its similarly elevated levels in some CC nonmalignant conditions, it is not specific enough to be used for CC population screening. CC -!- SIMILARITY: Contains 2 ANK repeats. CC -!- SIMILARITY: Contains 56 SEA domains. CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology CC and Haematology; CC URL="http://atlasgeneticsoncology.org/Genes/MUC16ID41455ch19q13.html"; CC -!- WEB RESOURCE: Name=Mucin database; CC URL="http://www.medkem.gu.se/mucinbiology/databases/"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF414442; AAL65133.2; -; mRNA. DR EMBL; AF361486; AAK74120.3; -; mRNA. DR EMBL; AK128681; BAC87568.1; -; mRNA. DR IPI; IPI00103552; -. DR RefSeq; NP_078966.2; NM_024690.2. DR UniGene; Hs.432676; -. DR ProteinModelPortal; Q8WXI7; -. DR SMR; Q8WXI7; 21966-22079. DR STRING; Q8WXI7; -. DR PhosphoSite; Q8WXI7; -. DR DMDM; 74716283; -. DR PRIDE; Q8WXI7; -. DR GeneID; 94025; -. DR KEGG; hsa:94025; -. DR CTD; 94025; -. DR GeneCards; GC19M008960; -. DR H-InvDB; HIX0021715; -. DR HGNC; HGNC:15582; MUC16. DR HPA; CAB055172; -. DR HPA; HPA026659; -. DR MIM; 606154; gene. DR neXtProt; NX_Q8WXI7; -. DR PharmGKB; PA31314; -. DR eggNOG; NOG12793; -. DR KO; K16145; -. DR Reactome; REACT_17015; Metabolism of proteins. DR GenomeRNAi; 94025; -. DR NextBio; 78314; -. DR CleanEx; HS_MUC16; -. DR Genevestigator; Q8WXI7; -. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell. DR GO; GO:0019898; C:extrinsic to membrane; IDA:UniProtKB. DR GO; GO:0005796; C:Golgi lumen; TAS:Reactome. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0007155; P:cell adhesion; NAS:UniProtKB. DR GO; GO:0016266; P:O-glycan processing; TAS:Reactome. DR GO; GO:0043687; P:post-translational protein modification; TAS:Reactome. DR InterPro; IPR000082; SEA. DR Pfam; PF01390; SEA; 55. DR SMART; SM00200; SEA; 23. DR PROSITE; PS50297; ANK_REP_REGION; FALSE_NEG. DR PROSITE; PS50088; ANK_REPEAT; FALSE_NEG. DR PROSITE; PS50024; SEA; 11. PE 1: Evidence at protein level; KW ANK repeat; Cell membrane; Complete proteome; KW Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; KW Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; KW Transmembrane; Transmembrane helix. FT CHAIN 1 22152 Mucin-16. FT /FTId=PRO_0000259595. FT TOPO_DOM 1 22096 Extracellular (Potential). FT TRANSMEM 22097 22117 Helical; (Potential). FT TOPO_DOM 22118 22152 Cytoplasmic (Potential). FT DOMAIN 12070 12190 SEA 1. FT DOMAIN 12229 12339 SEA 2. FT DOMAIN 12386 12504 SEA 3. FT DOMAIN 12539 12660 SEA 4. FT DOMAIN 12697 12815 SEA 5. FT DOMAIN 12853 12971 SEA 6. FT DOMAIN 13009 13127 SEA 7. FT DOMAIN 13165 13283 SEA 8. FT DOMAIN 13315 13439 SEA 9. FT DOMAIN 13477 13595 SEA 10. FT DOMAIN 13633 13751 SEA 11. FT REPEAT 13767 13801 ANK 1. FT DOMAIN 13789 13907 SEA 12. FT DOMAIN 13939 14063 SEA 13. FT DOMAIN 14101 14219 SEA 14. FT DOMAIN 14251 14375 SEA 15. FT DOMAIN 14410 14531 SEA 16. FT DOMAIN 14567 14689 SEA 17. FT DOMAIN 14723 14845 SEA 18. FT DOMAIN 14877 15001 SEA 19. FT DOMAIN 15039 15157 SEA 20. FT DOMAIN 15195 15313 SEA 21. FT DOMAIN 15348 15469 SEA 22. FT DOMAIN 15507 15625 SEA 23. FT DOMAIN 15664 15774 SEA 24. FT DOMAIN 15812 15936 SEA 25. FT DOMAIN 16123 16247 SEA 26. FT DOMAIN 16279 16403 SEA 27. FT DOMAIN 16437 16559 SEA 28. FT DOMAIN 16591 16715 SEA 29. FT DOMAIN 16750 16871 SEA 30. FT DOMAIN 16905 17027 SEA 31. FT DOMAIN 17065 17183 SEA 32. FT DOMAIN 17221 17339 SEA 33. FT DOMAIN 17378 17488 SEA 34. FT DOMAIN 17534 17644 SEA 35. FT DOMAIN 17689 17807 SEA 36. FT DOMAIN 18001 18119 SEA 37. FT DOMAIN 18313 18431 SEA 38. FT DOMAIN 18625 18743 SEA 39. FT REPEAT 18915 18949 ANK 2. FT DOMAIN 18937 19055 SEA 40. FT DOMAIN 19243 19367 SEA 41. FT DOMAIN 19555 19679 SEA 42. FT DOMAIN 19866 19990 SEA 43. FT DOMAIN 20184 20302 SEA 44. FT DOMAIN 20340 20458 SEA 45. FT DOMAIN 20496 20614 SEA 46. FT DOMAIN 20652 20770 SEA 47. FT DOMAIN 20804 20926 SEA 48. FT DOMAIN 20964 21082 SEA 49. FT DOMAIN 21117 21238 SEA 50. FT DOMAIN 21273 21394 SEA 51. FT DOMAIN 21433 21542 SEA 52. FT DOMAIN 21565 21683 SEA 53. FT DOMAIN 21717 21826 SEA 54. FT DOMAIN 21836 21957 SEA 55. FT DOMAIN 21959 22080 SEA 56. FT COMPBIAS 14 12085 Thr-rich. FT COMPBIAS 1638 3055 Ser-rich. FT COMPBIAS 3961 4385 Ser-rich. FT COMPBIAS 7085 10395 Ser-rich. FT MOD_RES 955 955 Phosphothreonine. FT CARBOHYD 139 139 N-linked (GlcNAc...) (Potential). FT CARBOHYD 434 434 N-linked (GlcNAc...) (Potential). FT CARBOHYD 787 787 N-linked (GlcNAc...) (Potential). FT CARBOHYD 930 930 N-linked (GlcNAc...) (Potential). FT CARBOHYD 957 957 N-linked (GlcNAc...) (Potential). FT CARBOHYD 1375 1375 N-linked (GlcNAc...) (Potential). FT CARBOHYD 1633 1633 N-linked (GlcNAc...) (Potential). FT CARBOHYD 1840 1840 N-linked (GlcNAc...) (Potential). FT CARBOHYD 1877 1877 N-linked (GlcNAc...) (Potential). FT CARBOHYD 1890 1890 N-linked (GlcNAc...) (Potential). FT CARBOHYD 2345 2345 N-linked (GlcNAc...) (Potential). FT CARBOHYD 2375 2375 N-linked (GlcNAc...) (Potential). FT CARBOHYD 2737 2737 N-linked (GlcNAc...) (Potential). FT CARBOHYD 3086 3086 N-linked (GlcNAc...) (Potential). FT CARBOHYD 3179 3179 N-linked (GlcNAc...) (Potential). FT CARBOHYD 3502 3502 N-linked (GlcNAc...) (Potential). FT CARBOHYD 4222 4222 N-linked (GlcNAc...) (Potential). FT CARBOHYD 4500 4500 N-linked (GlcNAc...) (Potential). FT CARBOHYD 4608 4608 N-linked (GlcNAc...) (Potential). FT CARBOHYD 4615 4615 N-linked (GlcNAc...) (Potential). FT CARBOHYD 4626 4626 N-linked (GlcNAc...) (Potential). FT CARBOHYD 4863 4863 N-linked (GlcNAc...) (Potential). FT CARBOHYD 5098 5098 N-linked (GlcNAc...) (Potential). FT CARBOHYD 5133 5133 N-linked (GlcNAc...) (Potential). FT CARBOHYD 5230 5230 N-linked (GlcNAc...) (Potential). FT CARBOHYD 5322 5322 N-linked (GlcNAc...) (Potential). FT CARBOHYD 5396 5396 N-linked (GlcNAc...) (Potential). FT CARBOHYD 5472 5472 N-linked (GlcNAc...) (Potential). FT CARBOHYD 5691 5691 N-linked (GlcNAc...) (Potential). FT CARBOHYD 5865 5865 N-linked (GlcNAc...) (Potential). FT CARBOHYD 6090 6090 N-linked (GlcNAc...) (Potential). FT CARBOHYD 6734 6734 N-linked (GlcNAc...) (Potential). FT CARBOHYD 6861 6861 N-linked (GlcNAc...) (Potential). FT CARBOHYD 6963 6963 N-linked (GlcNAc...) (Potential). FT CARBOHYD 8031 8031 N-linked (GlcNAc...) (Potential). FT CARBOHYD 8057 8057 N-linked (GlcNAc...) (Potential). FT CARBOHYD 8326 8326 N-linked (GlcNAc...) (Potential). FT CARBOHYD 8620 8620 N-linked (GlcNAc...) (Potential). FT CARBOHYD 8686 8686 N-linked (GlcNAc...) (Potential). FT CARBOHYD 8915 8915 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9204 9204 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9495 9495 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9787 9787 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9920 9920 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10077 10077 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10175 10175 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10512 10512 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10702 10702 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10751 10751 N-linked (GlcNAc...) (Potential). FT CARBOHYD 11055 11055 N-linked (GlcNAc...) (Potential). FT CARBOHYD 11226 11226 N-linked (GlcNAc...) (Potential). FT CARBOHYD 11265 11265 N-linked (GlcNAc...) (Potential). FT CARBOHYD 11369 11369 N-linked (GlcNAc...) (Potential). FT CARBOHYD 11596 11596 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12081 12081 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12102 12102 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12118 12118 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12170 12170 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12237 12237 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12274 12274 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12395 12395 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12416 12416 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12432 12432 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12551 12551 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12572 12572 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12588 12588 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12706 12706 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12727 12727 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12743 12743 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12826 12826 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12862 12862 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12883 12883 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12982 12982 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13018 13018 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13039 13039 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13055 13055 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13174 13174 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13195 13195 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13211 13211 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13330 13330 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13351 13351 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13367 13367 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13423 13423 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13486 13486 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13507 13507 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13523 13523 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13579 13579 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13642 13642 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13663 13663 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13679 13679 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13798 13798 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13819 13819 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13835 13835 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13954 13954 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13975 13975 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13991 13991 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14110 14110 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14131 14131 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14147 14147 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14266 14266 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14287 14287 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14303 14303 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14359 14359 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14422 14422 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14459 14459 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14580 14580 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14601 14601 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14617 14617 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14736 14736 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14757 14757 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14773 14773 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14825 14825 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14892 14892 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14913 14913 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14929 14929 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15048 15048 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15069 15069 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15204 15204 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15241 15241 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15360 15360 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15381 15381 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15397 15397 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15516 15516 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15537 15537 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15672 15672 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15693 15693 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15709 15709 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15827 15827 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15848 15848 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15864 15864 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15947 15947 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15983 15983 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16004 16004 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16020 16020 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16138 16138 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16159 16159 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16175 16175 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16258 16258 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16294 16294 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16315 16315 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16331 16331 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16450 16450 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16471 16471 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16487 16487 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16539 16539 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16606 16606 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16627 16627 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16643 16643 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16762 16762 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16783 16783 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16799 16799 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16918 16918 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16939 16939 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16955 16955 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17074 17074 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17095 17095 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17111 17111 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17230 17230 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17251 17251 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17386 17386 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17407 17407 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17423 17423 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17542 17542 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17563 17563 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17579 17579 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17698 17698 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17719 17719 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17854 17854 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17875 17875 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17891 17891 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18010 18010 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18031 18031 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18047 18047 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18166 18166 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18187 18187 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18203 18203 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18322 18322 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18343 18343 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18359 18359 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18478 18478 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18499 18499 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18515 18515 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18634 18634 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18655 18655 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18790 18790 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18811 18811 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18827 18827 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18946 18946 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18967 18967 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18983 18983 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19039 19039 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19102 19102 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19123 19123 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19139 19139 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19258 19258 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19279 19279 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19295 19295 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19414 19414 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19435 19435 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19451 19451 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19570 19570 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19591 19591 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19607 19607 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19726 19726 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19747 19747 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19763 19763 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19881 19881 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19902 19902 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19918 19918 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20037 20037 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20058 20058 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20074 20074 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20157 20157 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20193 20193 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20214 20214 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20230 20230 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20349 20349 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20370 20370 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20505 20505 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20526 20526 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20661 20661 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20682 20682 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20698 20698 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20817 20817 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20838 20838 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20973 20973 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20994 20994 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21010 21010 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21129 21129 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21150 21150 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21166 21166 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21285 21285 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21306 21306 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21378 21378 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21389 21389 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21441 21441 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21461 21461 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21477 21477 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21574 21574 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21595 21595 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21725 21725 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21745 21745 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21840 21840 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21857 21857 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21899 21899 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21932 21932 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21971 21971 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22008 22008 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22062 22062 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22068 22068 N-linked (GlcNAc...) (Potential). FT DISULFID 12128 12148 Potential. FT DISULFID 12284 12304 Potential. FT DISULFID 12442 12462 Potential. FT DISULFID 12598 12618 Potential. FT DISULFID 12753 12773 Potential. FT DISULFID 12909 12929 Potential. FT DISULFID 13065 13085 Potential. FT DISULFID 13221 13241 Potential. FT DISULFID 13377 13397 Potential. FT DISULFID 13533 13553 Potential. FT DISULFID 13689 13709 Potential. FT DISULFID 13845 13865 Potential. FT DISULFID 14001 14021 Potential. FT DISULFID 14157 14177 Potential. FT DISULFID 14313 14333 Potential. FT DISULFID 14469 14489 Potential. FT DISULFID 14627 14647 Potential. FT DISULFID 14783 14803 Potential. FT DISULFID 14939 14959 Potential. FT DISULFID 15095 15115 Potential. FT DISULFID 15251 15271 Potential. FT DISULFID 15407 15427 Potential. FT DISULFID 15563 15583 Potential. FT DISULFID 15719 15739 Potential. FT DISULFID 15874 15894 Potential. FT DISULFID 16185 16205 Potential. FT DISULFID 16341 16361 Potential. FT DISULFID 16497 16517 Potential. FT DISULFID 16653 16673 Potential. FT DISULFID 16809 16829 Potential. FT DISULFID 16965 16985 Potential. FT DISULFID 17121 17141 Potential. FT DISULFID 17277 17297 Potential. FT DISULFID 17433 17453 Potential. FT DISULFID 17589 17609 Potential. FT DISULFID 17745 17765 Potential. FT DISULFID 18057 18077 Potential. FT DISULFID 18369 18389 Potential. FT DISULFID 18681 18701 Potential. FT DISULFID 18993 19013 Potential. FT DISULFID 19305 19325 Potential. FT DISULFID 19617 19637 Potential. FT DISULFID 19928 19948 Potential. FT DISULFID 20396 20416 Potential. FT DISULFID 20552 20572 Potential. FT DISULFID 20708 20728 Potential. FT DISULFID 20864 20884 Potential. FT DISULFID 21020 21040 Potential. FT DISULFID 21176 21196 Potential. FT DISULFID 21332 21352 Potential. FT DISULFID 21621 21641 Potential. FT DISULFID 21771 21791 Potential. FT DISULFID 22018 22038 Potential. FT VARIANT 545 545 T -> A (in dbSNP:rs17000957). FT /FTId=VAR_056592. FT VARIANT 1015 1015 R -> G (in dbSNP:rs17000950). FT /FTId=VAR_056593. FT VARIANT 1032 1032 S -> T (in dbSNP:rs10411228). FT /FTId=VAR_056594. FT VARIANT 1041 1041 P -> S (in dbSNP:rs10406202). FT /FTId=VAR_056595. FT VARIANT 1162 1162 T -> I (in dbSNP:rs17000947). FT /FTId=VAR_056596. FT VARIANT 1266 1266 K -> N (in dbSNP:rs1596797). FT /FTId=VAR_056597. FT VARIANT 1353 1353 H -> Y (in dbSNP:rs12611293). FT /FTId=VAR_056598. FT VARIANT 1400 1400 K -> N (in dbSNP:rs1596798). FT /FTId=VAR_056599. FT VARIANT 1833 1833 L -> F (in dbSNP:rs4520945). FT /FTId=VAR_056600. FT VARIANT 1953 1953 S -> P (in dbSNP:rs1108380). FT /FTId=VAR_056601. FT VARIANT 2058 2058 S -> P (in dbSNP:rs1574479). FT /FTId=VAR_056602. FT VARIANT 2150 2150 I -> V (in dbSNP:rs10407633). FT /FTId=VAR_056603. FT VARIANT 2271 2271 T -> A (in dbSNP:rs11085805). FT /FTId=VAR_056604. FT VARIANT 2288 2288 V -> L (in dbSNP:rs10410933). FT /FTId=VAR_056605. FT VARIANT 2356 2356 D -> E (in dbSNP:rs10416013). FT /FTId=VAR_056606. FT VARIANT 2747 2747 A -> T (in dbSNP:rs10402538). FT /FTId=VAR_056607. FT VARIANT 2786 2786 M -> I (in dbSNP:rs17000886). FT /FTId=VAR_056608. FT VARIANT 2834 2834 T -> M (in dbSNP:rs10407623). FT /FTId=VAR_056609. FT VARIANT 3574 3574 R -> H (in dbSNP:rs2591594). FT /FTId=VAR_056610. FT VARIANT 5743 5743 H -> D (in dbSNP:rs1559172). FT /FTId=VAR_056611. FT VARIANT 5756 5756 A -> T (in dbSNP:rs1559171). FT /FTId=VAR_056612. FT VARIANT 5854 5854 F -> V (in dbSNP:rs1862460). FT /FTId=VAR_056613. FT VARIANT 7065 7065 T -> A (in dbSNP:rs17000770). FT /FTId=VAR_056614. FT VARIANT 7274 7274 I -> V (in dbSNP:rs1867691). FT /FTId=VAR_056615. FT VARIANT 10509 10509 T -> N (in dbSNP:rs11670461). FT /FTId=VAR_056616. FT CONFLICT 8346 8346 D -> A (in Ref. 3; AAK74120). FT CONFLICT 8580 8580 A -> T (in Ref. 3; AAK74120). FT CONFLICT 9061 9061 S -> T (in Ref. 3; AAK74120). FT CONFLICT 9074 9074 A -> T (in Ref. 3; AAK74120). FT CONFLICT 9131 9131 D -> E (in Ref. 3; AAK74120). FT CONFLICT 9407 9407 Q -> R (in Ref. 3; AAK74120). FT CONFLICT 9504 9504 T -> A (in Ref. 3; AAK74120). FT CONFLICT 9610 9610 S -> P (in Ref. 3; AAK74120). FT CONFLICT 9852 9852 D -> E (in Ref. 3; AAK74120). FT CONFLICT 9901 9901 Y -> F (in Ref. 3; AAK74120). FT CONFLICT 10171 10171 F -> L (in Ref. 3; AAK74120). FT CONFLICT 10396 10396 T -> S (in Ref. 3; AAK74120). FT CONFLICT 10515 10515 R -> M (in Ref. 3; AAK74120). FT CONFLICT 10522 10522 L -> P (in Ref. 3; AAK74120). FT CONFLICT 10563 10563 L -> F (in Ref. 3; AAK74120). FT CONFLICT 10830 10830 P -> S (in Ref. 3; AAK74120). FT CONFLICT 11156 11156 S -> F (in Ref. 3; AAK74120). FT CONFLICT 11201 11201 A -> G (in Ref. 3; AAK74120). FT CONFLICT 11457 11457 G -> D (in Ref. 3; AAK74120). FT CONFLICT 11506 11506 K -> R (in Ref. 3; AAK74120). FT CONFLICT 11577 11577 V -> A (in Ref. 3; AAK74120). FT CONFLICT 11783 11783 G -> E (in Ref. 3; AAK74120). FT CONFLICT 12142 12142 M -> T (in Ref. 3; AAK74120). FT CONFLICT 12226 12226 A -> T (in Ref. 3; AAK74120). FT CONFLICT 12582 12582 L -> V (in Ref. 3; AAK74120). FT CONFLICT 12629 12629 L -> V (in Ref. 3; AAK74120). FT CONFLICT 12695 12695 A -> SAT (in Ref. 3; AAK74120). FT CONFLICT 12713 12713 Q -> K (in Ref. 3; AAK74120). FT CONFLICT 12720 12720 H -> C (in Ref. 3; AAK74120). FT CONFLICT 12735 12735 G -> S (in Ref. 3; AAK74120). FT CONFLICT 12744 12899 Missing (in Ref. 3; AAK74120). FT CONFLICT 13352 13352 T -> A (in Ref. 3; AAK74120). FT CONFLICT 13519 14924 Missing (in Ref. 3; AAK74120). FT CONFLICT 15053 15053 D -> N (in Ref. 3; AAK74120). FT CONFLICT 15215 20515 Missing (in Ref. 3; AAK74120). FT CONFLICT 20515 20515 V -> E (in Ref. 5; BAC87568). FT CONFLICT 20760 21071 Missing (in Ref. 5; BAC87568). FT CONFLICT 20839 20839 T -> I (in Ref. 3; AAK74120). FT CONFLICT 20842 20842 R -> S (in Ref. 3; AAK74120). FT CONFLICT 20977 20977 T -> I (in Ref. 3; AAK74120). FT CONFLICT 21384 21384 H -> P (in Ref. 3; AAK74120 and 5; FT BAC87568). FT CONFLICT 21487 21487 S -> C (in Ref. 3; AAK74120 and 5; FT BAC87568). FT CONFLICT 21602 21602 K -> Q (in Ref. 3; AAK74120 and 5; FT BAC87568). FT CONFLICT 21686 21695 YNEPGLDEPP -> HHTLQRQSTT (in Ref. 3; FT AAK74120). FT CONFLICT 21691 21691 L -> P (in Ref. 3; AAK74120). SQ SEQUENCE 22152 AA; 2353428 MW; B3E7BDF19997A440 CRC64; MLKPSGLPGS SSPTRSLMTG SRSTKATPEM DSGLTGATLS PKTSTGAIVV TEHTLPFTSP DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTDTE KSEVSSSIHP RPETSAPGAE TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWASVGS TTDLPAMGFL KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP PSTWGIPQST LTFEFSEVPS LDTKSASLPT PGQSLNTIPD SDASTASSSL SKSPEKNPRA RMMTSTKAIS ASSFQSTGFT ETPEGSASPS MAGHEPRVPT SGTGDPRYAS ESMSYPDPSK ASSAMTSTSL ASKLTTLFST GQAARSGSSS SPISLSTEKE TSFLSPTAST SRKTSLFLGP SMARQPNILV HLQTSALTLS PTSTLNMSQE EPPELTSSQT IAEEEGTTAE TQTLTFTPSE TPTSLLPVSS PTEPTARRKS SPETWASSIS VPAKTSLVET TDGTLVTTIK MSSQAAQGNS TWPAPAEETG TSPAGTSPGS PEVSTTLKIM SSKEPSISPE IRSTVRNSPW KTPETTVPME TTVEPVTLQS TALGSGSTSI SHLPTGTTSP TKSPTENMLA TERVSLSPSP PEAWTNLYSG TPGGTRQSLA TMSSVSLESP TARSITGTGQ QSSPELVSKT TGMEFSMWHG STGGTTGDTH VSLSTSSNIL EDPVTSPNSV SSLTDKSKHK TETWVSTTAI PSTVLNNKIM AAEQQTSRSV DEAYSSTSSW SDQTSGSDIT LGASPDVTNT LYITSTAQTT SLVSLPSGDQ GITSLTNPSG GKTSSASSVT SPSIGLETLR ANVSAVKSDI APTAGHLSQT SSPAEVSILD VTTAPTPGIS TTITTMGTNS ISTTTPNPEV GMSTMDSTPA TERRTTSTEH PSTWSSTAAS DSWTVTDMTS NLKVARSPGT ISTMHTTSFL ASSTELDSMS TPHGRITVIG TSLVTPSSDA SAVKTETSTS ERTLSPSDTT ASTPISTFSR VQRMSISVPD ILSTSWTPSS TEAEDVPVSM VSTDHASTKT DPNTPLSTFL FDSLSTLDWD TGRSLSSATA TTSAPQGATT PQELTLETMI SPATSQLPFS IGHITSAVTP AAMARSSGVT FSRPDPTSKK AEQTSTQLPT TTSAHPGQVP RSAATTLDVI PHTAKTPDAT FQRQGQTALT TEARATSDSW NEKEKSTPSA PWITEMMNSV SEDTIKEVTS SSSVLKDPEY AGHKLGIWDD FIPKFGKAAH MRELPLLSPP QDKEAIHPST NTVETTGWVT SSEHASHSTI PAHSASSKLT SPVVTTSTRE QAIVSMSTTT WPESTRARTE PNSFLTIELR DVSPYMDTSS TTQTSIISSP GSTAITKGPR TEITSSKRIS SSFLAQSMRS SDSPSEAITR LSNFPAMTES GGMILAMQTS PPGATSLSAP TLDTSATASW TGTPLATTQR FTYSEKTTLF SKGPEDTSQP SPPSVEETSS SSSLVPIHAT TSPSNILLTS QGHSPSSTPP VTSVFLSETS GLGKTTDMSR ISLEPGTSLP PNLSSTAGEA LSTYEASRDT KAIHHSADTA VTNMEATSSE YSPIPGHTKP SKATSPLVTS HIMGDITSST SVFGSSETTE IETVSSVNQG LQERSTSQVA SSATETSTVI THVSSGDATT HVTKTQATFS SGTSISSPHQ FITSTNTFTD VSTNPSTSLI MTESSGVTIT TQTGPTGAAT QGPYLLDTST MPYLTETPLA VTPDFMQSEK TTLISKGPKD VTWTSPPSVA ETSYPSSLTP FLVTTIPPAT STLQGQHTSS PVSATSVLTS GLVKTTDMLN TSMEPVTNSP QNLNNPSNEI LATLAATTDI ETIHPSINKA VTNMGTASSA HVLHSTLPVS SEPSTATSPM VPASSMGDAL ASISIPGSET TDIEGEPTSS LTAGRKENST LQEMNSTTES NIILSNVSVG AITEATKMEV PSFDATFIPT PAQSTKFPDI FSVASSRLSN SPPMTISTHM TTTQTGSSGA TSKIPLALDT STLETSAGTP SVVTEGFAHS KITTAMNNDV KDVSQTNPPF QDEASSPSSQ APVLVTTLPS SVAFTPQWHS TSSPVSMSSV LTSSLVKTAG KVDTSLETVT SSPQSMSNTL DDISVTSAAT TDIETTHPSI NTVVTNVGTT GSAFESHSTV SAYPEPSKVT SPNVTTSTME DTTISRSIPK SSKTTRTETE TTSSLTPKLR ETSISQEITS STETSTVPYK ELTGATTEVS RTDVTSSSST SFPGPDQSTV SLDISTETNT RLSTSPIMTE SAEITITTQT GPHGATSQDT FTMDPSNTTP QAGIHSAMTH GFSQLDVTTL MSRIPQDVSW TSPPSVDKTS SPSSFLSSPA MTTPSLISST LPEDKLSSPM TSLLTSGLVK ITDILRTRLE PVTSSLPNFS STSDKILATS KDSKDTKEIF PSINTEETNV KANNSGHESH SPALADSETP KATTQMVITT TVGDPAPSTS MPVHGSSETT NIKREPTYFL TPRLRETSTS QESSFPTDTS FLLSKVPTGT ITEVSSTGVN SSSKISTPDH DKSTVPPDTF TGEIPRVFTS SIKTKSAEMT ITTQASPPES ASHSTLPLDT STTLSQGGTH STVTQGFPYS EVTTLMGMGP GNVSWMTTPP VEETSSVSSL MSSPAMTSPS PVSSTSPQSI PSSPLPVTAL PTSVLVTTTD VLGTTSPESV TSSPPNLSSI THERPATYKD TAHTEAAMHH STNTAVTNVG TSGSGHKSQS SVLADSETSK ATPLMSTTST LGDTSVSTST PNISQTNQIQ TEPTASLSPR LRESSTSEKT SSTTETNTAF SYVPTGAITQ ASRTEISSSR TSISDLDRPT IAPDISTGMI TRLFTSPIMT KSAEMTVTTQ TTTPGATSQG ILPWDTSTTL FQGGTHSTVS QGFPHSEITT LRSRTPGDVS WMTTPPVEET SSGFSLMSPS MTSPSPVSST SPESIPSSPL PVTALLTSVL VTTTNVLGTT SPETVTSSPP NLSSPTQERL TTYKDTAHTE AMHASMHTNT AVANVGTSIS GHESQSSVPA DSHTSKATSP MGITFAMGDT SVSTSTPAFF ETRIQTESTS SLIPGLRDTR TSEEINTVTE TSTVLSEVPT TTTTEVSRTE VITSSRTTIS GPDHSKMSPY ISTETITRLS TFPFVTGSTE MAITNQTGPI GTISQATLTL DTSSTASWEG THSPVTQRFP HSEETTTMSR STKGVSWQSP PSVEETSSPS SPVPLPAITS HSSLYSAVSG SSPTSALPVT SLLTSGRRKT IDMLDTHSEL VTSSLPSASS FSGEILTSEA STNTETIHFS ENTAETNMGT TNSMHKLHSS VSIHSQPSGH TPPKVTGSMM EDAIVSTSTP GSPETKNVDR DSTSPLTPEL KEDSTALVMN STTESNTVFS SVSLDAATEV SRAEVTYYDP TFMPASAQST KSPDISPEAS SSHSNSPPLT ISTHKTIATQ TGPSGVTSLG QLTLDTSTIA TSAGTPSART QDFVDSETTS VMNNDLNDVL KTSPFSAEEA NSLSSQAPLL VTTSPSPVTS TLQEHSTSSL VSVTSVPTPT LAKITDMDTN LEPVTRSPQN LRNTLATSEA TTDTHTMHPS INTAMANVGT TSSPNEFYFT VSPDSDPYKA TSAVVITSTS GDSIVSTSMP RSSAMKKIES ETTFSLIFRL RETSTSQKIG SSSDTSTVFD KAFTAATTEV SRTELTSSSR TSIQGTEKPT MSPDTSTRSV TMLSTFAGLT KSEERTIATQ TGPHRATSQG TLTWDTSITT SQAGTHSAMT HGFSQLDLST LTSRVPEYIS GTSPPSVEKT SSSSSLLSLP AITSPSPVPT TLPESRPSSP VHLTSLPTSG LVKTTDMLAS VASLPPNLGS TSHKIPTTSE DIKDTEKMYP STNIAVTNVG TTTSEKESYS SVPAYSEPPK VTSPMVTSFN IRDTIVSTSM PGSSEITRIE MESTFSVAHG LKGTSTSQDP IVSTEKSAVL HKLTTGATET SRTEVASSRR TSIPGPDHST ESPDISTEVI PSLPISLGIT ESSNMTIITR TGPPLGSTSQ GTFTLDTPTT SSRAGTHSMA TQEFPHSEMT TVMNKDPEIL SWTIPPSIEK TSFSSSLMPS PAMTSPPVSS TLPKTIHTTP SPMTSLLTPS LVMTTDTLGT SPEPTTSSPP NLSSTSHVIL TTDEDTTAIE AMHPSTSTAA TNVETTCSGH GSQSSVLTDS EKTKATAPMD TTSTMGHTTV STSMSVSSET TKIKRESTYS LTPGLRETSI SQNASFSTDT SIVLSEVPTG TTAEVSRTEV TSSGRTSIPG PSQSTVLPEI STRTMTRLFA SPTMTESAEM TIPTQTGPSG STSQDTLTLD TSTTKSQAKT HSTLTQRFPH SEMTTLMSRG PGDMSWQSSP SLENPSSLPS LLSLPATTSP PPISSTLPVT ISSSPLPVTS LLTSSPVTTT DMLHTSPELV TSSPPKLSHT SDERLTTGKD TTNTEAVHPS TNTAASNVEI PSFGHESPSS ALADSETSKA TSPMFITSTQ EDTTVAISTP HFLETSRIQK ESISSLSPKL RETGSSVETS SAIETSAVLS EVSIGATTEI SRTEVTSSSR TSISGSAEST MLPEISTTRK IIKFPTSPIL AESSEMTIKT QTSPPGSTSE STFTLDTSTT PSLVITHSTM TQRLPHSEIT TLVSRGAGDV PRPSSLPVEE TSPPSSQLSL SAMISPSPVS STLPASSHSS SASVTSPLTP GQVKTTEVLD ASAEPETSSP PSLSSTSVEI LATSEVTTDT EKIHPFPNTA VTKVGTSSSG HESPSSVLPD SETTKATSAM GTISIMGDTS VSTLTPALSN TRKIQSEPAS SLTTRLRETS TSEETSLATE ANTVLSKVST GATTEVSRTE AISFSRTSMS GPEQSTMSQD ISIGTIPRIS ASSVLTESAK MTITTQTGPS ESTLESTLNL NTATTPSWVE THSIVIQGFP HPEMTTSMGR GPGGVSWPSP PFVKETSPPS SPLSLPAVTS PHPVSTTFLA HIPPSPLPVT SLLTSGPATT TDILGTSTEP GTSSSSSLST TSHERLTTYK DTAHTEAVHP STNTGGTNVA TTSSGYKSQS SVLADSSPMC TTSTMGDTSV LTSTPAFLET RRIQTELASS LTPGLRESSG SEGTSSGTKM STVLSKVPTG ATTEISKEDV TSIPGPAQST ISPDISTRTV SWFSTSPVMT ESAEITMNTH TSPLGATTQG TSTLATSSTT SLTMTHSTIS QGFSHSQMST LMRRGPEDVS WMSPPLLEKT RPSFSLMSSP ATTSPSPVSS TLPESISSSP LPVTSLLTSG LAKTTDMLHK SSEPVTNSPA NLSSTSVEIL ATSEVTTDTE KTHPSSNRTV TDVGTSSSGH ESTSFVLADS QTSKVTSPMV ITSTMEDTSV STSTPGFFET SRIQTEPTSS LTLGLRKTSS SEGTSLATEM STVLSGVPTG ATAEVSRTEV TSSSRTSISG FAQLTVSPET STETITRLPT SSIMTESAEM MIKTQTDPPG STPESTHTVD ISTTPNWVET HSTVTQRFSH SEMTTLVSRS PGDMLWPSQS SVEETSSASS LLSLPATTSP SPVSSTLVED FPSASLPVTS LLTPGLVITT DRMGISREPG TSSTSNLSST SHERLTTLED TVDTEDMQPS THTAVTNVRT SISGHESQSS VLSDSETPKA TSPMGTTYTM GETSVSISTS DFFETSRIQI EPTSSLTSGL RETSSSERIS SATEGSTVLS EVPSGATTEV SRTEVISSRG TSMSGPDQFT ISPDISTEAI TRLSTSPIMT ESAESAITIE TGSPGATSEG TLTLDTSTTT FWSGTHSTAS PGFSHSEMTT LMSRTPGDVP WPSLPSVEEA SSVSSSLSSP AMTSTSFFSA LPESISSSPH PVTALLTLGP VKTTDMLRTS SEPETSSPPN LSSTSAEILA TSEVTKDREK IHPSSNTPVV NVGTVIYKHL SPSSVLADLV TTKPTSPMAT TSTLGNTSVS TSTPAFPETM MTQPTSSLTS GLREISTSQE TSSATERSAS LSGMPTGATT KVSRTEALSL GRTSTPGPAQ STISPEISTE TITRISTPLT TTGSAEMTIT PKTGHSGASS QGTFTLDTSS RASWPGTHSA ATHRSPHSGM TTPMSRGPED VSWPSRPSVE KTSPPSSLVS LSAVTSPSPL YSTPSESSHS SPLRVTSLFT PVMMKTTDML DTSLEPVTTS PPSMNITSDE SLATSKATME TEAIQLSENT AVTQMGTISA RQEFYSSYPG LPEPSKVTSP VVTSSTIKDI VSTTIPASSE ITRIEMESTS TLTPTPRETS TSQEIHSATK PSTVPYKALT SATIEDSMTQ VMSSSRGPSP DQSTMSQDIS SEVITRLSTS PIKAESTEMT ITTQTGSPGA TSRGTLTLDT STTFMSGTHS TASQGFSHSQ MTALMSRTPG DVPWLSHPSV EEASSASFSL SSPVMTSSSP VSSTLPDSIH SSSLPVTSLL TSGLVKTTEL LGTSSEPETS SPPNLSSTSA EILATTEVTT DTEKLEMTNV VTSGYTHESP SSVLADSVTT KATSSMGITY PTGDTNVLTS TPAFSDTSRI QTKSKLSLTP GLMETSISEE TSSATEKSTV LSSVPTGATT EVSRTEAISS SRTSIPGPAQ STMSSDTSME TITRISTPLT RKESTDMAIT PKTGPSGATS QGTFTLDSSS TASWPGTHSA TTQRFPQSVV TTPMSRGPED VSWPSPLSVE KNSPPSSLVS SSSVTSPSPL YSTPSGSSHS SPVPVTSLFT SIMMKATDML DASLEPETTS APNMNITSDE SLATSKATTE TEAIHVFENT AASHVETTSA TEELYSSSPG FSEPTKVISP VVTSSSIRDN MVSTTMPGSS GITRIEIESM SSLTPGLRET RTSQDITSST ETSTVLYKMS SGATPEVSRT EVMPSSRTSI PGPAQSTMSL DISDEVVTRL STSPIMTESA EITITTQTGY SLATSQVTLP LGTSMTFLSG THSTMSQGLS HSEMTNLMSR GPESLSWTSP RFVETTRSSS SLTSLPLTTS LSPVSSTLLD SSPSSPLPVT SLILPGLVKT TEVLDTSSEP KTSSSPNLSS TSVEIPATSE IMTDTEKIHP SSNTAVAKVR TSSSVHESHS SVLADSETTI TIPSMGITSA VDDTTVFTSN PAFSETRRIP TEPTFSLTPG FRETSTSEET TSITETSAVL YGVPTSATTE VSMTEIMSSN RTHIPDSDQS TMSPDIITEV ITRLSSSSMM SESTQMTITT QKSSPGATAQ STLTLATTTA PLARTHSTVP PRFLHSEMTT LMSRSPENPS WKSSPFVEKT SSSSSLLSLP VTTSPSVSST LPQSIPSSSF SVTSLLTPGM VKTTDTSTEP GTSLSPNLSG TSVEILAASE VTTDTEKIHP SSSMAVTNVG TTSSGHELYS SVSIHSEPSK ATYPVGTPSS MAETSISTSM PANFETTGFE AEPFSHLTSG FRKTNMSLDT SSVTPTNTPS SPGSTHLLQS SKTDFTSSAK TSSPDWPPAS QYTEIPVDII TPFNASPSIT ESTGITSFPE SRFTMSVTES THHLSTDLLP SAETISTGTV MPSLSEAMTS FATTGVPRAI SGSGSPFSRT ESGPGDATLS TIAESLPSST PVPFSSSTFT TTDSSTIPAL HEITSSSATP YRVDTSLGTE SSTTEGRLVM VSTLDTSSQP GRTSSTPILD TRMTESVELG TVTSAYQVPS LSTRLTRTDG IMEHITKIPN EAAHRGTIRP VKGPQTSTSP ASPKGLHTGG TKRMETTTTA LKTTTTALKT TSRATLTTSV YTPTLGTLTP LNASRQMAST ILTEMMITTP YVFPDVPETT SSLATSLGAE TSTALPRTTP SVLNRESETT ASLVSRSGAE RSPVIQTLDV SSSEPDTTAS WVIHPAETIP TVSKTTPNFF HSELDTVSST ATSHGADVSS AIPTNISPSE LDALTPLVTI SGTDTSTTFP TLTKSPHETE TRTTWLTHPA ETSSTIPRTI PNFSHHESDA TPSIATSPGA ETSSAIPIMT VSPGAEDLVT SQVTSSGTDR NMTIPTLTLS PGEPKTIASL VTHPEAQTSS AIPTSTISPA VSRLVTSMVT SLAAKTSTTN RALTNSPGEP ATTVSLVTHP AQTSPTVPWT TSIFFHSKSD TTPSMTTSHG AESSSAVPTP TVSTEVPGVV TPLVTSSRAV ISTTIPILTL SPGEPETTPS MATSHGEEAS SAIPTPTVSP GVPGVVTSLV TSSRAVTSTT IPILTFSLGE PETTPSMATS HGTEAGSAVP TVLPEVPGMV TSLVASSRAV TSTTLPTLTL SPGEPETTPS MATSHGAEAS STVPTVSPEV PGVVTSLVTS SSGVNSTSIP TLILSPGELE TTPSMATSHG AEASSAVPTP TVSPGVSGVV TPLVTSSRAV TSTTIPILTL SSSEPETTPS MATSHGVEAS SAVLTVSPEV PGMVTSLVTS SRAVTSTTIP TLTISSDEPE TTTSLVTHSE AKMISAIPTL AVSPTVQGLV TSLVTSSGSE TSAFSNLTVA SSQPETIDSW VAHPGTEASS VVPTLTVSTG EPFTNISLVT HPAESSSTLP RTTSRFSHSE LDTMPSTVTS PEAESSSAIS TTISPGIPGV LTSLVTSSGR DISATFPTVP ESPHESEATA SWVTHPAVTS TTVPRTTPNY SHSEPDTTPS IATSPGAEAT SDFPTITVSP DVPDMVTSQV TSSGTDTSIT IPTLTLSSGE PETTTSFITY SETHTSSAIP TLPVSPGASK MLTSLVISSG TDSTTTFPTL TETPYEPETT AIQLIHPAET NTMVPKTTPK FSHSKSDTTL PVAITSPGPE ASSAVSTTTI SPDMSDLVTS LVPSSGTDTS TTFPTLSETP YEPETTVTWL THPAETSTTV SGTIPNFSHR GSDTAPSMVT SPGVDTRSGV PTTTIPPSIP GVVTSQVTSS ATDTSTAIPT LTPSPGEPET TASSATHPGT QTGFTVPIRT VPSSEPDTMA SWVTHPPQTS TPVSRTTSSF SHSSPDATPV MATSPRTEAS SAVLTTISPG APEMVTSQIT SSGAATSTTV PTLTHSPGMP ETTALLSTHP RTGTSKTFPA STVFPQVSET TASLTIRPGA ETSTALPTQT TSSLFTLLVT GTSRVDLSPT ASPGVSAKTA PLSTHPGTET STMIPTSTLS LGLLETTGLL ATSSSAETST STLTLTVSPA VSGLSSASIT TDKPQTVTSW NTETSPSVTS VGPPEFSRTV TGTTMTLIPS EMPTPPKTSH GEGVSPTTIL RTTMVEATNL ATTGSSPTVA KTTTTFNTLA GSLFTPLTTP GMSTLASESV TSRTSYNHRS WISTTSSYNR RYWTPATSTP VTSTFSPGIS TSSIPSSTAA TVPFMVPFTL NFTITNLQYE EDMRHPGSRK FNATERELQG LLKPLFRNSS LEYLYSGCRL ASLRPEKDSS AMAVDAICTH RPDPEDLGLD RERLYWELSN LTNGIQELGP YTLDRNSLYV NGFTHRSSMP TTSTPGTSTV DVGTSGTPSS SPSPTAAGPL LMPFTLNFTI TNLQYEEDMR RTGSRKFNTM ESVLQGLLKP LFKNTSVGPL YSGCRLTLLR PEKDGAATGV DAICTHRLDP KSPGLNREQL YWELSKLTND IEELGPYTLD RNSLYVNGFT HQSSVSTTST PGTSTVDLRT SGTPSSLSSP TIMAAGPLLV PFTLNFTITN LQYGEDMGHP GSRKFNTTER VLQGLLGPIF KNTSVGPLYS GCRLTSLRSE KDGAATGVDA ICIHHLDPKS PGLNRERLYW ELSQLTNGIK ELGPYTLDRN SLYVNGFTHR TSVPTTSTPG TSTVDLGTSG TPFSLPSPAT AGPLLVLFTL NFTITNLKYE EDMHRPGSRK FNTTERVLQT LLGPMFKNTS VGLLYSGCRL TLLRSEKDGA ATGVDAICTH RLDPKSPGLD REQLYWELSQ LTNGIKELGP YTLDRNSLYV NGFTHWIPVP TSSTPGTSTV DLGSGTPSSL PSPTAAGPLL VPFTLNFTIT NLQYEEDMHH PGSRKFNTTE RVLQGLLGPM FKNTSVGLLY SGCRLTLLRS EKDGAATGVD AICTHRLDPK SPGVDREQLY WELSQLTNGI KELGPYTLDR NSLYVNGFTH QTSAPNTSTP GTSTVDLGTS GTPSSLPSPT SAGPLLVPFT LNFTITNLQY EEDMRHPGSR KFNTTERVLQ GLLKPLFKST SVGPLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGV DREQLYWELS QLTNGIKELG PYTLDRNSLY VNGFTHQTSA PNTSTPGTST VDLGTSGTPS SLPSPTSAGP LLVPFTLNFT ITNLQYEEDM HHPGSRKFNT TERVLQGLLG PMFKNTSVGL LYSGCRLTLL RPEKNGAATG MDAICSHRLD PKSPGLNREQ LYWELSQLTH GIKELGPYTL DRNSLYVNGF THRSSVAPTS TPGTSTVDLG TSGTPSSLPS PTTAVPLLVP FTLNFTITNL QYGEDMRHPG SRKFNTTERV LQGLLGPLFK NSSVGPLYSG CRLISLRSEK DGAATGVDAI CTHHLNPQSP GLDREQLYWQ LSQMTNGIKE LGPYTLDRNS LYVNGFTHRS SGLTTSTPWT STVDLGTSGT PSPVPSPTTA GPLLVPFTLN FTITNLQYEE DMHRPGSRKF NTTERVLQGL LSPIFKNSSV GPLYSGCRLT SLRPEKDGAA TGMDAVCLYH PNPKRPGLDR EQLYWELSQL THNITELGPY SLDRDSLYVN GFTHQNSVPT TSTPGTSTVY WATTGTPSSF PGHTEPGPLL IPFTFNFTIT NLHYEENMQH PGSRKFNTTE RVLQGLLKPL FKNTSVGPLY SGCRLTSLRP EKDGAATGMD AVCLYHPNPK RPGLDREQLY WELSQLTHNI TELGPYSLDR DSLYVNGFTH QNSVPTTSTP GTSTVYWATT GTPSSFPGHT EPGPLLIPFT FNFTITNLHY EENMQHPGSR KFNTTERVLQ GLLKPLFKNT SVGPLYSGCR LTLLRPEKHE AATGVDTICT HRVDPIGPGL DRERLYWELS QLTNSITELG PYTLDRDSLY VNGFNPRSSV PTTSTPGTST VHLATSGTPS SLPGHTAPVP LLIPFTLNFT ITNLHYEENM QHPGSRKFNT TERVLQGLLK PLFKNTSVGP LYSGCRLTLL RPEKHEAATG VDTICTHRVD PIGPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX XTSAGPLLVP FTLNFTITNL QYEEDMHHPG SRKFNTTERV LQGLLGPMFK NTSVGLLYSG CRLTLLRPEK NGAATGMDAI CSHRLDPKSP GLDREQLYWE LSQLTHGIKE LGPYTLDRNS LYVNGFTHRS SVAPTSTPGT STVDLGTSGT PSSLPSPTTA VPLLVPFTLN FTITNLQYGE DMRHPGSRKF NTTERVLQGL LGPLFKNSSV GPLYSGCRLI SLRSEKDGAA TGVDAICTHH LNPQSPGLDR EQLYWQLSQM TNGIKELGPY TLDRNSLYVN GFTHRSSGLT TSTPWTSTVD LGTSGTPSPV PSPTTAGPLL VPFTLNFTIT NLQYEEDMHR PGSRKFNATE RVLQGLLSPI FKNSSVGPLY SGCRLTSLRP EKDGAATGMD AVCLYHPNPK RPGLDREQLY WELSQLTHNI TELGPYSLDR DSLYVNGFTH QSSMTTTRTP DTSTMHLATS RTPASLSGPT TASPLLVLFT INCTITNLQY EEDMRRTGSR KFNTMESVLQ GLLKPLFKNT SVGPLYSGCR LTLLRPKKDG AATGVDAICT HRLDPKSPGL NREQLYWELS KLTNDIEELG PYTLDRNSLY VNGFTHQSSV STTSTPGTST VDLRTSGTPS SLSSPTIMXX XPLLXPFTXN XTITNLXXXX XMXXPGSRKF NTTERVLQGL LRPLFKNTSV SSLYSGCRLT LLRPEKDGAA TRVDAACTYR PDPKSPGLDR EQLYWELSQL THSITELGPY TLDRVSLYVN GFNPRSSVPT TSTPGTSTVH LATSGTPSSL PGHTXXXPLL XPFTXNXTIT NLXXXXXMXX PGSRKFNTTE RVLQGLLKPL FRNSSLEYLY SGCRLASLRP EKDSSAMAVD AICTHRPDPE DLGLDRERLY WELSNLTNGI QELGPYTLDR NSLYVNGFTH RSSGLTTSTP WTSTVDLGTS GTPSPVPSPT TAGPLLVPFT LNFTITNLQY EEDMHRPGSR RFNTTERVLQ GLLTPLFKNT SVGPLYSGCR LTLLRPEKQE AATGVDTICT HRVDPIGPGL DRERLYWELS QLTNSITELG PYTLDRDSLY VNGFNPWSSV PTTSTPGTST VHLATSGTPS SLPGHTAPVP LLIPFTLNFT ITDLHYEENM QHPGSRKFNT TERVLQGLLK PLFKSTSVGP LYSGCRLTLL RPEKHGAATG VDAICTLRLD PTGPGLDRER LYWELSQLTN SVTELGPYTL DRDSLYVNGF THRSSVPTTS IPGTSAVHLE TSGTPASLPG HTAPGPLLVP FTLNFTITNL QYEEDMRHPG SRKFSTTERV LQGLLKPLFK NTSVSSLYSG CRLTLLRPEK DGAATRVDAV CTHRPDPKSP GLDRERLYWK LSQLTHGITE LGPYTLDRHS LYVNGFTHQS SMTTTRTPDT STMHLATSRT PASLSGPTTA SPLLVLFTIN FTITNLRYEE NMHHPGSRKF NTTERVLQGL LRPVFKNTSV GPLYSGCRLT TLRPKKDGAA TKVDAICTYR PDPKSPGLDR EQLYWELSQL THSITELGPY TQDRDSLYVN GFTHRSSVPT TSIPGTSAVH LETSGTPASL PGHTAPGPLL VPFTLNFTIT NLQYEEDMRH PGSRKFNTTE RVLQGLLKPL FKSTSVGPLY SGCRLTLLRP EKRGAATGVD TICTHRLDPL NPGLDREQLY WELSKLTRGI IELGPYLLDR GSLYVNGFTH RTSVPTTSTP GTSTVDLGTS GTPFSLPSPA XXXPLLXPFT XNXTITNLXX XXXMXXPGSR KFNTTERVLQ TLLGPMFKNT SVGLLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGV DREQLYWELS QLTNGIKELG PYTLDRNSLY VNGFTHWIPV PTSSTPGTST VDLGSGTPSS LPSPTTAGPL LVPFTLNFTI TNLKYEEDMH CPGSRKFNTT ERVLQSLLGP MFKNTSVGPL YSGCRLTLLR SEKDGAATGV DAICTHRLDP KSPGVDREQL YWELSQLTNG IKELGPYTLD RNSLYVNGFT HQTSAPNTST PGTSTVDLGT SGTPSSLPSP TXXXPLLXPF TXNXTITNLX XXXXMXXPGS RKFNTTEXVL QGLLXPXFKN XSVGXLYSGC RLTXLRXEKX GAATGXDAIC XHXXXPKXPG LXXEXLYWEL SXLTXXIXEL GPYTLDRXSL YVNGFTHWIP VPTSSTPGTS TVDLGSGTPS SLPSPTTAGP LLVPFTLNFT ITNLKYEEDM HCPGSRKFNT TERVLQSLLG PMFKNTSVGP LYSGCRLTSL RSEKDGAATG VDAICTHRVD PKSPGVDREQ LYWELSQLTN GIKELGPYTL DRNSLYVNGF THQTSAPNTS TPGTSTVXXG TSGTPSSXPX XTSAGPLLVP FTLNFTITNL QYEEDMHHPG SRKFNTTERV LQGLLGPMFK NTSVGLLYSG CRLTLLRPEK NGATTGMDAI CTHRLDPKSP GLXXEXLYWE LSXLTXXIXE LGPYTLDRXS LYVNGFTHXX SXPTTSTPGT STVXXGTSGT PSSXPXXTXX XPLLXPFTXN XTITNLXXXX XMXXPGSRKF NTTERVLQGL LKPLFRNSSL EYLYSGCRLA SLRPEKDSSA MAVDAICTHR PDPEDLGLDR ERLYWELSNL TNGIQELGPY TLDRNSLYVN GFTHRSSMPT TSTPGTSTVD VGTSGTPSSS PSPTTAGPLL IPFTLNFTIT NLQYGEDMGH PGSRKFNTTE RVLQGLLGPI FKNTSVGPLY SGCRLTSLRS EKDGAATGVD AICIHHLDPK SPGLNRERLY WELSQLTNGI KELGPYTLDR NSLYVNGFTH RTSVPTTSTP GTSTVDLGTS GTPFSLPSPA TAGPLLVLFT LNFTITNLKY EEDMHRPGSR KFNTTERVLQ TLLGPMFKNT SVGLLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGL XXEXLYWELS XLTXXIXELG PYTLDRXSLY VNGFTHXXSX PTTSTPGTST VXXGTSGTPS SXPXXTXXXP LLXPFTXNXT ITNLXXXXXM XXPGSRKFNT TERVLQGLLR PVFKNTSVGP LYSGCRLTLL RPKKDGAATK VDAICTYRPD PKSPGLDREQ LYWELSQLTH SITELGPYTQ DRDSLYVNGF THRSSVPTTS IPGTSAVHLE TTGTPSSFPG HTEPGPLLIP FTFNFTITNL RYEENMQHPG SRKFNTTERV LQGLLTPLFK NTSVGPLYSG CRLTLLRPEK QEAATGVDTI CTHRVDPIGP GLDRERLYWE LSQLTNSITE LGPYTLDRDS LYVDGFNPWS SVPTTSTPGT STVHLATSGT PSPLPGHTAP VPLLIPFTLN FTITDLHYEE NMQHPGSRKF NTTERVLQGL LKPLFKSTSV GPLYSGCRLT LLRPEKHGAA TGVDAICTLR LDPTGPGLDR ERLYWELSQL TNSITELGPY TLDRDSLYVN GFNPWSSVPT TSTPGTSTVH LATSGTPSSL PGHTTAGPLL VPFTLNFTIT NLKYEEDMHC PGSRKFNTTE RVLQSLHGPM FKNTSVGPLY SGCRLTLLRS EKDGAATGVD AICTHRLDPK SPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH XXSXPTTSTP GTSTVXXGTS GTPSSXPXXT XXXPLLXPFT XNXTITNLXX XXXMXXPGSR KFNTTEXVLQ GLLXPXFKNX SVGXLYSGCR LTXLRXEKXG AATGXDAICX HXXXPKXPGL XXEXLYWELS XLTNSITELG PYTLDRDSLY VNGFTHRSSM PTTSIPGTSA VHLETSGTPA SLPGHTAPGP LLVPFTLNFT ITNLQYEEDM RHPGSRKFNT TERVLQGLLK PLFKSTSVGP LYSGCRLTLL RPEKRGAATG VDTICTHRLD PLNPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX XTXXXPLLXP FTXNXTITNL XXXXXMXXPG SRKFNTTEXV LQGLLXPXFK NXSVGXLYSG CRLTXLRXEK XGAATGXDAI CXHXXXPKXP GLXXEXLYWE LSXLTXXIXE LGPYTLDRXS LYVNGFHPRS SVPTTSTPGT STVHLATSGT PSSLPGHTAP VPLLIPFTLN FTITNLHYEE NMQHPGSRKF NTTERVLQGL LGPMFKNTSV GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLXX EXLYWELSXL TXXIXELGPY TLDRXSLYVN GFTHXXSXPT TSTPGTSTVX XGTSGTPSSX PXXTXXXPLL XPFTXNXTIT NLXXXXXMXX PGSRKFNTTE XVLQGLLXPX FKNXSVGXLY SGCRLTXLRX EKXGAATGXD AICXHXXXPK XPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH QNSVPTTSTP GTSTVYWATT GTPSSFPGHT EPGPLLIPFT FNFTITNLHY EENMQHPGSR KFNTTERVLQ GLLTPLFKNT SVGPLYSGCR LTLLRPEKQE AATGVDTICT HRVDPIGPGL XXEXLYWELS XLTXXIXELG PYTLDRXSLY VNGFTHXXSX PTTSTPGTST VXXGTSGTPS SXPXXTXXXP LLXPFTXNXT ITNLXXXXXM XXPGSRKFNT TEXVLQGLLX PXFKNXSVGX LYSGCRLTXL RXEKXGAATG XDAICXHXXX PKXPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THRSSVPTTS SPGTSTVHLA TSGTPSSLPG HTAPVPLLIP FTLNFTITNL HYEENMQHPG SRKFNTTERV LQGLLKPLFK STSVGPLYSG CRLTLLRPEK HGAATGVDAI CTLRLDPTGP GLXXEXLYWE LSXLTXXIXE LGPYTLDRXS LYVNGFTHXX SXPTTSTPGT STVXXGTSGT PSSXPXXTXX XPLLXPFTXN XTITNLXXXX XMXXPGSRKF NTTEXVLQGL LXPXFKNXSV GXLYSGCRLT XLRXEKXGAA TGXDAICXHX XXPKXPGLXX EXLYWELSXL TXXIXELGPY TLDRXSLYVN GFTHRTSVPT TSTPGTSTVH LATSGTPSSL PGHTAPVPLL IPFTLNFTIT NLQYEEDMHR PGSRKFNTTE RVLQGLLSPI FKNSSVGPLY SGCRLTSLRP EKDGAATGMD AVCLYHPNPK RPGLDREQLY CELSQLTHNI TELGPYSLDR DSLYVNGFTH QNSVPTTSTP GTSTVYWATT GTPSSFPGHT XXXPLLXPFT XNXTITNLXX XXXMXXPGSR KFNTTEXVLQ GLLXPXFKNX SVGXLYSGCR LTXLRXEKXG AATGXDAICX HXXXPKXPGL XXEXLYWELS XLTXXIXELG PYTLDRXSLY VNGFTHWSSG LTTSTPWTST VDLGTSGTPS PVPSPTTAGP LLVPFTLNFT ITNLQYEEDM HRPGSRKFNA TERVLQGLLS PIFKNTSVGP LYSGCRLTLL RPEKQEAATG VDTICTHRVD PIGPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX XTXXXPLLXP FTXNXTITNL XXXXXMXXPG SRKFNTTEXV LQGLLXPXFK NXSVGXLYSG CRLTXLRXEK XGAATGXDAI CXHXXXPKXP GLXXEXLYWE LSXLTXXIXE LGPYTLDRXS LYVNGFTHRS FGLTTSTPWT STVDLGTSGT PSPVPSPTTA GPLLVPFTLN FTITNLQYEE DMHRPGSRKF NTTERVLQGL LTPLFRNTSV SSLYSGCRLT LLRPEKDGAA TRVDAVCTHR PDPKSPGLXX EXLYWELSXL TXXIXELGPY TLDRXSLYVN GFTHXXSXPT TSTPGTSTVX XGTSGTPSSX PXXTXXXPLL XPFTXNXTIT NLXXXXXMXX PGSRKFNTTE XVLQGLLXPX FKNXSVGXLY SGCRLTXLRX EKXGAATGXD AICXHXXXPK XPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH WIPVPTSSTP GTSTVDLGSG TPSSLPSPTT AGPLLVPFTL NFTITNLQYG EDMGHPGSRK FNTTERVLQG LLGPIFKNTS VGPLYSGCRL TSLRSEKDGA ATGVDAICIH HLDPKSPGLX XEXLYWELSX LTXXIXELGP YTLDRXSLYV NGFTHXXSXP TTSTPGTSTV XXGTSGTPSS XPXXTXXXPL LXPFTXNXTI TNLXXXXXMX XPGSRKFNTT EXVLQGLLXP XFKNXSVGXL YSGCRLTXLR XEKXGAATGX DAICXHXXXP KXPGLXXEXL YWELSXLTXX IXELGPYTLD RXSLYVNGFT HQTFAPNTST PGTSTVDLGT SGTPSSLPSP TSAGPLLVPF TLNFTITNLQ YEEDMHHPGS RKFNTTERVL QGLLGPMFKN TSVGLLYSGC RLTLLRPEKN GAATRVDAVC THRPDPKSPG LXXEXLYWEL SXLTXXIXEL GPYTLDRXSL YVNGFTHXXS XPTTSTPGTS TVXXGTSGTP SSXPXXTAPV PLLIPFTLNF TITNLHYEEN MQHPGSRKFN TTERVLQGLL KPLFKSTSVG PLYSGCRLTL LRPEKHGAAT GVDAICTLRL DPTGPGLDRE RLYWELSQLT NSVTELGPYT LDRDSLYVNG FTQRSSVPTT SIPGTSAVHL ETSGTPASLP GHTAPGPLLV PFTLNFTITN LQYEVDMRHP GSRKFNTTER VLQGLLKPLF KSTSVGPLYS GCRLTLLRPE KRGAATGVDT ICTHRLDPLN PGLDREQLYW ELSKLTRGII ELGPYLLDRG SLYVNGFTHR NFVPITSTPG TSTVHLGTSE TPSSLPRPIV PGPLLVPFTL NFTITNLQYE EAMRHPGSRK FNTTERVLQG LLRPLFKNTS IGPLYSSCRL TLLRPEKDKA ATRVDAICTH HPDPQSPGLN REQLYWELSQ LTHGITELGP YTLDRDSLYV DGFTHWSPIP TTSTPGTSIV NLGTSGIPPS LPETTXXXPL LXPFTXNXTI TNLXXXXXMX XPGSRKFNTT ERVLQGLLKP LFKSTSVGPL YSGCRLTLLR PEKDGVATRV DAICTHRPDP KIPGLDRQQL YWELSQLTHS ITELGPYTLD RDSLYVNGFT QRSSVPTTST PGTFTVQPET SETPSSLPGP TATGPVLLPF TLNFTITNLQ YEEDMHRPGS RKFNTTERVL QGLLMPLFKN TSVSSLYSGC RLTLLRPEKD GAATRVDAVC THRPDPKSPG LDRERLYWKL SQLTHGITEL GPYTLDRHSL YVNGFTHQSS MTTTRTPDTS TMHLATSRTP ASLSGPTTAS PLLVLFTINF TITNLRYEEN MHHPGSRKFN TTERVLQGLL RPVFKNTSVG PLYSGCRLTL LRPKKDGAAT KVDAICTYRP DPKSPGLDRE QLYWELSQLT HSITELGPYT LDRDSLYVNG FTQRSSVPTT SIPGTPTVDL GTSGTPVSKP GPSAASPLLV LFTLNFTITN LRYEENMQHP GSRKFNTTER VLQGLLRSLF KSTSVGPLYS GCRLTLLRPE KDGTATGVDA ICTHHPDPKS PRLDREQLYW ELSQLTHNIT ELGHYALDND SLFVNGFTHR SSVSTTSTPG TPTVYLGASK TPASIFGPSA ASHLLILFTL NFTITNLRYE ENMWPGSRKF NTTERVLQGL LRPLFKNTSV GPLYSGSRLT LLRPEKDGEA TGVDAICTHR PDPTGPGLDR EQLYLELSQL THSITELGPY TLDRDSLYVN GFTHRSSVPT TSTGVVSEEP FTLNFTINNL RYMADMGQPG SLKFNITDNV MKHLLSPLFQ RSSLGARYTG CRVIALRSVK NGAETRVDLL CTYLQPLSGP GLPIKQVFHE LSQQTHGITR LGPYSLDKDS LYLNGYNEPG LDEPPTTPKP ATTFLPPLSE ATTAMGYHLK TLTLNFTISN LQYSPDMGKG SATFNSTEGV LQHLLRPLFQ KSSMGPFYLG CQLISLRPEK DGAATGVDTT CTYHPDPVGP GLDIQQLYWE LSQLTHGVTQ LGFYVLDRDS LFINGYAPQN LSIRGEYQIN FHIVNWNLSN PDPTSSEYIT LLRDIQDKVT TLYKGSQLHD TFRFCLVTNL TMDSVLVTVK ALFSSNLDPS LVEQVFLDKT LNASFHWLGS TYQLVDIHVT EMESSVYQPT SSSSTQHFYL NFTITNLPYS QDKAQPGTTN YQRNKRNIED ALNQLFRNSS IKSYFSDCQV STFRSVPNRH HTGVDSLCNF SPLARRVDRV AIYEEFLRMT RNGTQLQNFT LDRSSVLVDG YSPNRNEPLT GNSDLPFWAV ILIGLAGLLG LITCLICGVL VTTRRRKKEG EYNVQQQCPG YYQSHLDLED LQ //