ID   MUC16_HUMAN             Reviewed;       14507 AA.
AC   Q8WXI7; B5ME49; Q6ZQW5; Q96RK2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-MAY-2016, sequence version 3.
DT   27-MAR-2024, entry version 154.
DE   RecName: Full=Mucin-16 {ECO:0000305};
DE            Short=MUC-16;
DE   AltName: Full=Ovarian cancer-related tumor marker CA125 {ECO:0000303|PubMed:12218296};
DE            Short=CA-125 {ECO:0000303|PubMed:12218296};
DE   AltName: Full=Ovarian carcinoma antigen CA125 {ECO:0000303|PubMed:11369781};
GN   Name=MUC16 {ECO:0000312|HGNC:HGNC:15582};
GN   Synonyms=CA125 {ECO:0000303|PubMed:11786729};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-10429, SEQUENCE REVISION TO N-TERMINUS,
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=12218296; DOI=10.1159/000064032;
RA   O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K.;
RT   "The CA 125 gene: a newly discovered extension of the glycosylated N-
RT   terminal domain doubles the size of this extracellular superstructure.";
RL   Tumor Biol. 23:154-169(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 10430-14507, REGION, AND POLYMORPHISM.
RX   PubMed=11786729; DOI=10.1159/000050638;
RA   O'Brien T.J., Beard J.B., Underwood L.J., Dennis R.A., Santin A.D.,
RA   York L.;
RT   "The CA 125 gene: an extracellular superstructure dominated by repeat
RT   sequences.";
RL   Tumor Biol. 22:348-366(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 8295-14507, PROTEIN SEQUENCE OF 13715-13720
RP   AND 14338-14350, AND TISSUE SPECIFICITY.
RX   PubMed=11369781; DOI=10.1074/jbc.m103554200;
RA   Yin B.W.T., Lloyd K.O.;
RT   "Molecular cloning of the CA125 ovarian cancer antigen: identification as a
RT   new mucin, MUC16.";
RL   J. Biol. Chem. 276:27371-27375(2001).
RN   [5]
RP   SEQUENCE REVISION.
RA   Lloyd K.O., Yin B.W.T.;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12828-14050.
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [7]
RP   PHOSPHORYLATION.
RX   PubMed=9276028; DOI=10.1159/000218041;
RA   Fendrick J.L., Konishi I., Geary S.M., Parmley T.H., Quirk J.G. Jr.,
RA   O'Brien T.J.;
RT   "CA125 phosphorylation is associated with its secretion from the WISH human
RT   amnion cell line.";
RL   Tumor Biol. 18:278-289(1997).
RN   [8]
RP   GLYCOSYLATION.
RX   PubMed=12734200; DOI=10.1074/jbc.m302741200;
RA   Kui Wong N., Easton R.L., Panico M., Sutton-Smith M., Morrison J.C.,
RA   Lattanzio F.A., Morris H.R., Clark G.F., Dell A., Patankar M.S.;
RT   "Characterization of the oligosaccharides associated with the human ovarian
RT   tumor marker CA125.";
RL   J. Biol. Chem. 278:28619-28634(2003).
RN   [9]
RP   INTERACTION WITH MSLN.
RX   PubMed=14676194; DOI=10.1074/jbc.m312372200;
RA   Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M.,
RA   Miyajima A.;
RT   "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell
RT   adhesion.";
RL   J. Biol. Chem. 279:9190-9198(2004).
RN   [10]
RP   REVIEW, AND POLYMORPHISM.
RX   PubMed=15788735; DOI=10.1177/1099800404274445;
RA   McLemore M.R., Aouizerat B.;
RT   "Introducing the MUC16 gene: implications for prevention and early
RT   detection in epithelial ovarian cancer.";
RL   Biol. Res. Nurs. 6:262-267(2005).
RN   [11]
RP   TISSUE SPECIFICITY.
RX   PubMed=16384952; DOI=10.1167/iovs.05-0735;
RA   Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K.;
RT   "Mucin characteristics of human corneal-limbal epithelial cells that
RT   exclude the rose bengal anionic dye.";
RL   Invest. Ophthalmol. Vis. Sci. 47:113-119(2006).
CC   -!- FUNCTION: Thought to provide a protective, lubricating barrier against
CC       particles and infectious agents at mucosal surfaces. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to MSLN. Binding to MSLN mediates heterotypic cell
CC       adhesion. This may contribute to the metastasis of ovarian cancer to
CC       the peritoneum by initiating cell attachment to the mesothelial
CC       epithelium via binding to MSLN.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein. Secreted, extracellular space. Note=May be liberated into the
CC       extracellular space following the phosphorylation of the intracellular
CC       C-terminus which induces the proteolytic cleavage and liberation of the
CC       extracellular domain.
CC   -!- TISSUE SPECIFICITY: Expressed in corneal and conjunctival epithelia (at
CC       protein level). Overexpressed in ovarian carcinomas and ovarian low
CC       malignant potential (LMP) tumors as compared to the expression in
CC       normal ovarian tissue and ovarian adenomas.
CC       {ECO:0000269|PubMed:11369781, ECO:0000269|PubMed:12218296,
CC       ECO:0000269|PubMed:16384952}.
CC   -!- INDUCTION: Up-regulated in ovarian cancer cells.
CC       {ECO:0000269|PubMed:12218296}.
CC   -!- DOMAIN: Composed of three domains, a Ser-, Thr-rich N-terminal domain,
CC       a repeated domain containing between 12 and 60 partially conserved
CC       tandem repeats of 156 amino acids and a C-terminal transmembrane
CC       contain domain with a short cytoplasmic tail.
CC       {ECO:0000269|PubMed:11786729}.
CC   -!- PTM: Heavily O-glycosylated; expresses both type 1 and type 2 core
CC       glycans. {ECO:0000269|PubMed:12734200}.
CC   -!- PTM: Heavily N-glycosylated; expresses primarily high mannose and
CC       complex bisecting type N-linked glycans. {ECO:0000269|PubMed:12734200}.
CC   -!- PTM: May be phosphorylated. Phosphorylation of the intracellular C-
CC       terminal domain may induce proteolytic cleavage and the liberation of
CC       the extracellular domain into the extracellular space.
CC       {ECO:0000269|PubMed:9276028}.
CC   -!- PTM: May contain numerous disulfide bridges. Association of several
CC       molecules of the secreted form may occur through interchain disulfide
CC       bridges providing an extraordinarily large gel-like matrix in the
CC       extracellular space or in the lumen of secretory ducts.
CC   -!- POLYMORPHISM: The number of repeats is highly polymorphic and can be
CC       composed between 12 and 60 extracellular mucin repeats.
CC       {ECO:0000305|PubMed:11786729}.
CC   -!- MISCELLANEOUS: Antigen that is the basis for a widely used serum assay
CC       for the monitoring of patients with ovarian epithelial cancer. Due to
CC       lack of sensitivity for stage I disease and lack of specificity, it is
CC       of little value in the detection of early ovarian cancer. Due to its
CC       similarly elevated levels in some nonmalignant conditions, it is not
CC       specific enough to be used for population screening.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL65133.2; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAC87568.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="https://atlasgeneticsoncology.org/gene/41455/MUC16";
CC   -!- WEB RESOURCE: Name=Mucin database;
CC       URL="http://www.medkem.gu.se/mucinbiology/databases/";
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DR   EMBL; AC008734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF414442; AAL65133.2; ALT_FRAME; mRNA.
DR   EMBL; AF361486; AAK74120.3; -; mRNA.
DR   EMBL; AK128681; BAC87568.1; ALT_INIT; mRNA.
DR   CCDS; CCDS54212.1; -.
DR   RefSeq; NP_078966.2; NM_024690.2.
DR   PDB; 7SA9; X-ray; 1.69 A; A/B=12665-12857.
DR   PDBsum; 7SA9; -.
DR   SMR; Q8WXI7; -.
DR   BioGRID; 125094; 27.
DR   IntAct; Q8WXI7; 2.
DR   STRING; 9606.ENSP00000381008; -.
DR   ChEMBL; CHEMBL3580482; -.
DR   DrugBank; DB01093; Dimethyl sulfoxide.
DR   DrugBank; DB04964; Oregovomab.
DR   GlyCosmos; Q8WXI7; 103 sites, 1 glycan.
DR   GlyGen; Q8WXI7; 207 sites, 2 O-linked glycans (105 sites).
DR   iPTMnet; Q8WXI7; -.
DR   PhosphoSitePlus; Q8WXI7; -.
DR   SwissPalm; Q8WXI7; -.
DR   BioMuta; MUC16; -.
DR   CPTAC; CPTAC-2227; -.
DR   EPD; Q8WXI7; -.
DR   jPOST; Q8WXI7; -.
DR   MassIVE; Q8WXI7; -.
DR   MaxQB; Q8WXI7; -.
DR   PaxDb; 9606-ENSP00000381008; -.
DR   PeptideAtlas; Q8WXI7; -.
DR   ProteomicsDB; 6210; -.
DR   ProteomicsDB; 75068; -.
DR   Pumba; Q8WXI7; -.
DR   ABCD; Q8WXI7; 12 sequenced antibodies.
DR   Antibodypedia; 3492; 1294 antibodies from 39 providers.
DR   CPTC; Q8WXI7; 3 antibodies.
DR   DNASU; 94025; -.
DR   Ensembl; ENST00000397910.8; ENSP00000381008.2; ENSG00000181143.16.
DR   GeneID; 94025; -.
DR   KEGG; hsa:94025; -.
DR   UCSC; uc002mkp.3; human.
DR   AGR; HGNC:15582; -.
DR   CTD; 94025; -.
DR   DisGeNET; 94025; -.
DR   GeneCards; MUC16; -.
DR   HGNC; HGNC:15582; MUC16.
DR   HPA; ENSG00000181143; Group enriched (adipose tissue, cervix, fallopian tube, salivary gland).
DR   MalaCards; MUC16; -.
DR   MIM; 606154; gene.
DR   neXtProt; NX_Q8WXI7; -.
DR   OpenTargets; ENSG00000181143; -.
DR   PharmGKB; PA31314; -.
DR   VEuPathDB; HostDB:ENSG00000181143; -.
DR   eggNOG; ENOG502RD3J; Eukaryota.
DR   GeneTree; ENSGT00440000039287; -.
DR   InParanoid; Q8WXI7; -.
DR   OMA; FAKPQDK; -.
DR   OrthoDB; 5324787at2759; -.
DR   PhylomeDB; Q8WXI7; -.
DR   TreeFam; TF335600; -.
DR   PathwayCommons; Q8WXI7; -.
DR   Reactome; R-HSA-5083625; Defective GALNT3 causes HFTC.
DR   Reactome; R-HSA-5083632; Defective C1GALT1C1 causes TNPS.
DR   Reactome; R-HSA-5083636; Defective GALNT12 causes CRCS1.
DR   Reactome; R-HSA-5621480; Dectin-2 family.
DR   Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR   Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
DR   SignaLink; Q8WXI7; -.
DR   BioGRID-ORCS; 94025; 10 hits in 1147 CRISPR screens.
DR   ChiTaRS; MUC16; human.
DR   GeneWiki; CA-125; -.
DR   GenomeRNAi; 94025; -.
DR   Pharos; Q8WXI7; Tbio.
DR   PRO; PR:Q8WXI7; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8WXI7; Protein.
DR   Bgee; ENSG00000181143; Expressed in nasal cavity epithelium and 79 other cell types or tissues.
DR   ExpressionAtlas; Q8WXI7; baseline and differential.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:UniProtKB.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0031982; C:vesicle; HDA:UniProtKB.
DR   GO; GO:0007155; P:cell adhesion; NAS:UniProtKB.
DR   Gene3D; 3.30.70.960; SEA domain; 16.
DR   InterPro; IPR028850; MUC16.
DR   InterPro; IPR000082; SEA_dom.
DR   InterPro; IPR036364; SEA_dom_sf.
DR   PANTHER; PTHR14672; MUCIN-16; 1.
DR   PANTHER; PTHR14672:SF1; MUCIN-16; 1.
DR   Pfam; PF01390; SEA; 16.
DR   SMART; SM00200; SEA; 7.
DR   SUPFAM; SSF82671; SEA domain; 16.
DR   PROSITE; PS50024; SEA; 16.
DR   Genevisible; B5ME49; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW   Secreted; Transmembrane; Transmembrane helix.
FT   CHAIN           1..14507
FT                   /note="Mucin-16"
FT                   /id="PRO_0000436078"
FT   TOPO_DOM        1..14451
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        14452..14472
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        14473..14507
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   REPEAT          12067..12223
FT                   /note="1"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          12072..12193
FT                   /note="SEA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          12224..12381
FT                   /note="2"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          12228..12349
FT                   /note="SEA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          12382..12537
FT                   /note="3"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          12386..12507
FT                   /note="SEA 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          12538..12692
FT                   /note="4"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          12542..12663
FT                   /note="SEA 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          12693..12848
FT                   /note="5"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          12697..12818
FT                   /note="SEA 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          12849..13004
FT                   /note="6"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          12853..12974
FT                   /note="SEA 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          13005..13160
FT                   /note="7"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          13009..13130
FT                   /note="SEA 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          13161..13316
FT                   /note="8"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          13165..13286
FT                   /note="SEA 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          13317..13472
FT                   /note="9"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          13321..13442
FT                   /note="SEA 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          13473..13628
FT                   /note="10"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          13477..13598
FT                   /note="SEA 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          13629..13784
FT                   /note="11"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          13633..13754
FT                   /note="SEA 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REPEAT          13785..13939
FT                   /note="12"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   DOMAIN          13789..13909
FT                   /note="SEA 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   DOMAIN          13922..14043
FT                   /note="SEA 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   DOMAIN          14073..14193
FT                   /note="SEA 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   DOMAIN          14198..14309
FT                   /note="SEA 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   DOMAIN          14319..14438
FT                   /note="SEA 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT   REGION          1..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          655..674
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          695..719
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          740..888
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          949..981
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1082..1101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1121..1149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1301..1378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1593..1641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1704..1757
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1846..1930
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2010..2033
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2064..2140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2153..2177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2393..2455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2566..2591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2789..2822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2838..2885
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2901..3006
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3019..3052
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3083..3148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3172..3235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3251..3276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3299..3392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3415..3436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3462..3491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3538..3588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3644..3672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3794..3829
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3843..3879
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3914..3982
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4024..4056
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4094..4121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4138..4166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4728..4748
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4845..4961
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5026..5066
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5128..5149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5221..5249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5271..5303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5328..5365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5381..5400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5426..5507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5519..5538
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5624..5654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5675..5696
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5727..5747
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5882..5931
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6054..6078
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6122..6149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6219..6251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6399..6425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6438..6459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6497..6545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6682..6714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6800..6822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6845..6865
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6886..6939
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6981..7004
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7028..7107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7143..7208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7279..7302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7320..7345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7360..7427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7437..7456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7463..7503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7527..7553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7577..7597
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7726..7782
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7825..7849
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7908..7927
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7970..8000
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8042..8078
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8111..8134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8312..8331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8342..8389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8411..8472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8604..8624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8674..8741
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8775..8880
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8995..9018
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          9147..9168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          9294..9460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          9611..9635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          9726..9753
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          9771..9791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          9869..9890
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          10175..10218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          10445..10469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          10544..10590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          10689..10719
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          10849..10872
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          10898..10926
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          11003..11036
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          11072..11092
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          11269..11301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          11358..11400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          11508..11537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          11583..11724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          11836..11861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          11913..11937
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          12067..13939
FT                   /note="12 X approximate tandem repeats"
FT                   /evidence="ECO:0000269|PubMed:11786729"
FT   REGION          12196..12226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          12353..12376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          12819..12849
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          12978..13003
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          13291..13317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          13603..13625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2857..2885
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2901..2966
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3299..3383
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3846..3879
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5221..5242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5519..5534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6497..6523
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7143..7159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7168..7208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7387..7427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7726..7754
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7762..7782
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8313..8331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8775..8830
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8844..8880
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9294..9413
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9424..9460
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9616..9635
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10175..10217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10449..10469
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13291..13315
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        139
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        434
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        787
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        930
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        957
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1375
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1633
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1840
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1877
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1890
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2345
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2375
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2737
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3085
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3501
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4220
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4498
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4606
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4613
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4624
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4861
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5096
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5228
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5320
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5394
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5470
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5689
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5863
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6088
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6732
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6859
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6961
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8029
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8055
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8324
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8618
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8684
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8913
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        9202
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        9493
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        9785
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        10075
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        10173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        10510
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        10700
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        10749
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11053
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11224
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11263
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11367
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11594
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12079
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12116
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12168
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12235
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12272
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12393
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12414
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12430
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12549
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12570
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12586
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12704
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12725
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12741
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12824
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12860
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12881
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12897
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13016
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13037
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13053
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13172
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13193
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13328
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13349
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13365
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13484
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13505
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13521
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13640
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13661
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13733
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13744
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13796
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13816
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13832
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13929
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13950
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14080
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14195
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14212
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14254
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14287
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14326
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14363
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14417
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14423
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        12126..12146
FT                   /evidence="ECO:0000255"
FT   DISULFID        12282..12302
FT                   /evidence="ECO:0000255"
FT   DISULFID        12440..12460
FT                   /evidence="ECO:0000255"
FT   DISULFID        12596..12616
FT                   /evidence="ECO:0000255"
FT   DISULFID        12751..12771
FT                   /evidence="ECO:0000255"
FT   DISULFID        12907..12927
FT                   /evidence="ECO:0000255"
FT   DISULFID        13063..13083
FT                   /evidence="ECO:0000255"
FT   DISULFID        13219..13239
FT                   /evidence="ECO:0000255"
FT   DISULFID        13375..13395
FT                   /evidence="ECO:0000255"
FT   DISULFID        13531..13551
FT                   /evidence="ECO:0000255"
FT   DISULFID        13687..13707
FT                   /evidence="ECO:0000255"
FT   DISULFID        13976..13996
FT                   /evidence="ECO:0000255"
FT   DISULFID        14126..14146
FT                   /evidence="ECO:0000255"
FT   DISULFID        14373..14393
FT                   /evidence="ECO:0000255"
FT   VARIANT         545
FT                   /note="T -> A (in dbSNP:rs17000957)"
FT                   /id="VAR_056592"
FT   VARIANT         1015
FT                   /note="R -> G (in dbSNP:rs17000950)"
FT                   /id="VAR_056593"
FT   VARIANT         1032
FT                   /note="S -> T (in dbSNP:rs10411228)"
FT                   /id="VAR_056594"
FT   VARIANT         1041
FT                   /note="P -> S (in dbSNP:rs10406202)"
FT                   /id="VAR_056595"
FT   VARIANT         1162
FT                   /note="T -> I (in dbSNP:rs17000947)"
FT                   /id="VAR_056596"
FT   VARIANT         1266
FT                   /note="K -> N (in dbSNP:rs1596797)"
FT                   /id="VAR_056597"
FT   VARIANT         1353
FT                   /note="H -> Y (in dbSNP:rs12611293)"
FT                   /id="VAR_056598"
FT   VARIANT         1400
FT                   /note="K -> N (in dbSNP:rs1596798)"
FT                   /id="VAR_056599"
FT   VARIANT         1833
FT                   /note="L -> F (in dbSNP:rs4520945)"
FT                   /id="VAR_056600"
FT   VARIANT         1953
FT                   /note="S -> P (in dbSNP:rs1108380)"
FT                   /id="VAR_056601"
FT   VARIANT         2058
FT                   /note="S -> P (in dbSNP:rs1574479)"
FT                   /id="VAR_056602"
FT   VARIANT         2150
FT                   /note="I -> V (in dbSNP:rs10407633)"
FT                   /id="VAR_056603"
FT   VARIANT         2271
FT                   /note="T -> A (in dbSNP:rs11085805)"
FT                   /id="VAR_056604"
FT   VARIANT         2288
FT                   /note="V -> L (in dbSNP:rs10410933)"
FT                   /id="VAR_056605"
FT   VARIANT         2356
FT                   /note="D -> E (in dbSNP:rs10416013)"
FT                   /id="VAR_056606"
FT   VARIANT         2747
FT                   /note="A -> T (in dbSNP:rs10402538)"
FT                   /id="VAR_056607"
FT   VARIANT         2786
FT                   /note="M -> I (in dbSNP:rs17000886)"
FT                   /id="VAR_056608"
FT   VARIANT         2834
FT                   /note="T -> M (in dbSNP:rs10407623)"
FT                   /id="VAR_056609"
FT   VARIANT         3573
FT                   /note="R -> H (in dbSNP:rs2591594)"
FT                   /id="VAR_056610"
FT   VARIANT         5741
FT                   /note="H -> D (in dbSNP:rs1559172)"
FT                   /id="VAR_056611"
FT   VARIANT         5754
FT                   /note="A -> T (in dbSNP:rs1559171)"
FT                   /id="VAR_056612"
FT   VARIANT         5852
FT                   /note="F -> V (in dbSNP:rs1862460)"
FT                   /id="VAR_056613"
FT   VARIANT         7063
FT                   /note="T -> A (in dbSNP:rs17000770)"
FT                   /id="VAR_056614"
FT   VARIANT         7272
FT                   /note="I -> V (in dbSNP:rs1867691)"
FT                   /id="VAR_056615"
FT   VARIANT         10507
FT                   /note="T -> N (in dbSNP:rs11670461)"
FT                   /id="VAR_056616"
FT   CONFLICT        1898
FT                   /note="Y -> D (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2506
FT                   /note="T -> A (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3190
FT                   /note="S -> T (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3202
FT                   /note="M -> V (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3932
FT                   /note="I -> V (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        4440
FT                   /note="S -> T (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        5682
FT                   /note="P -> T (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        6303
FT                   /note="V -> M (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        6655
FT                   /note="L -> V (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        6866
FT                   /note="E -> V (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        6895
FT                   /note="S -> C (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        6906
FT                   /note="A -> T (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        7191
FT                   /note="S -> F (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        7425
FT                   /note="L -> P (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        7475
FT                   /note="S -> P (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        7923
FT                   /note="D -> A (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        8301
FT                   /note="N -> T (in Ref. 2; AAL65133 and 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        8344
FT                   /note="D -> A (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        8578
FT                   /note="T -> A (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9059
FT                   /note="T -> S (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9072
FT                   /note="T -> A (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9129
FT                   /note="D -> E (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9213
FT                   /note="I -> T (in Ref. 2; AAL65133 and 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9405
FT                   /note="Q -> R (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9502
FT                   /note="A -> T (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9608
FT                   /note="P -> S (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9850
FT                   /note="D -> E (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9899
FT                   /note="Y -> F (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9920
FT                   /note="I -> T (in Ref. 2; AAL65133 and 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        10013
FT                   /note="L -> P (in Ref. 2; AAL65133 and 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        10169
FT                   /note="F -> L (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        10394
FT                   /note="S -> T (in Ref. 2; AAL65133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        10828
FT                   /note="P -> S (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        11154
FT                   /note="S -> F (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        11199
FT                   /note="A -> G (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        11455
FT                   /note="G -> D (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12514
FT                   /note="S -> T (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12580
FT                   /note="L -> V (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12692
FT                   /note="T -> TSA (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12832
FT                   /note="T -> A (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12834
FT                   /note="D -> H (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12836
FT                   /note="G -> E (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12842
FT                   /note="S -> A (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12846..12847
FT                   /note="SP -> GH (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12849..12850
FT                   /note="SA -> AP (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12873
FT                   /note="H -> R (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12892..12894
FT                   /note="GPM -> KPL (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12897
FT                   /note="N -> S (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12902
FT                   /note="L -> P (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12917
FT                   /note="N -> R (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12923..12925
FT                   /note="MDA -> VDT (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12928
FT                   /note="S -> T (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12934..12935
FT                   /note="KS -> LN (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12939
FT                   /note="N -> D (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12949
FT                   /note="Q -> K (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12952
FT                   /note="H -> R (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12955
FT                   /note="K -> I (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12961
FT                   /note="T -> L (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12965
FT                   /note="N -> G (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12976..12977
FT                   /note="SS -> NF (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12979..12980
FT                   /note="AP -> PI (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12990
FT                   /note="D -> H (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12995
FT                   /note="G -> E (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13002..13007
FT                   /note="SPTTAV -> RPIVPG (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13025..13027
FT                   /note="GED -> EEA (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13048
FT                   /note="G -> R (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13054..13056
FT                   /note="SSV -> TSI (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13062
FT                   /note="G -> S (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13332
FT                   /note="T -> I (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13341
FT                   /note="R -> H (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13386
FT                   /note="G -> K (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13394
FT                   /note="V -> I (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13398
FT                   /note="R -> H (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13402
FT                   /note="K -> Q (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13407
FT                   /note="D -> N (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13410
FT                   /note="R -> Q (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13414
FT                   /note="K -> E (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13472
FT                   /note="M -> T (in Ref. 6; BAC87568 and 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        14041..14050
FT                   /note="YNEPGPDEPP -> HHTLQRQSTT (in Ref. 6; BAC87568)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        14466
FT                   /note="V -> L (in Ref. 4; AAK74120)"
FT                   /evidence="ECO:0000305"
FT   STRAND          12699..12707
FT                   /evidence="ECO:0007829|PDB:7SA9"
FT   HELIX           12714..12717
FT                   /evidence="ECO:0007829|PDB:7SA9"
FT   HELIX           12722..12740
FT                   /evidence="ECO:0007829|PDB:7SA9"
FT   HELIX           12745..12747
FT                   /evidence="ECO:0007829|PDB:7SA9"
FT   STRAND          12748..12759
FT                   /evidence="ECO:0007829|PDB:7SA9"
FT   HELIX           12760..12762
FT                   /evidence="ECO:0007829|PDB:7SA9"
FT   STRAND          12764..12773
FT                   /evidence="ECO:0007829|PDB:7SA9"
FT   HELIX           12784..12794
FT                   /evidence="ECO:0007829|PDB:7SA9"
FT   TURN            12795..12799
FT                   /evidence="ECO:0007829|PDB:7SA9"
FT   STRAND          12804..12806
FT                   /evidence="ECO:0007829|PDB:7SA9"
SQ   SEQUENCE   14507 AA;  1519175 MW;  7D5E9A14F70EB90A CRC64;
     MLKPSGLPGS SSPTRSLMTG SRSTKATPEM DSGLTGATLS PKTSTGAIVV TEHTLPFTSP
     DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT
     SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW
     DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL
     SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI
     FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT
     AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT
     HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT
     RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS
     PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT
     HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA
     GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI
     STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT
     SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL
     PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT
     MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA
     APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT
     ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM
     SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS
     PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS
     LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE
     SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD
     PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA
     TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG
     EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS
     KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA
     TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET
     GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT
     MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA
     EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL
     GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA
     TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTYTE KSEVSSSIHP RPETSAPGAE
     TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI
     EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS
     TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA
     AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT
     SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP
     VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL
     THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST
     VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT
     ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE
     TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWTSVGS TTDLPAMGFL
     KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT
     PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF
     PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK
     TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV
     FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT
     MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP
     PTWGIPQSTL TFEFSEVPSL DTKSASLPTP GQSLNTIPDS DASTASSSLS KSPEKNPRAR
     MMTSTKAISA SSFQSTGFTE TPEGSASPSM AGHEPRVPTS GTGDPRYASE SMSYPDPSKA
     SSAMTSTSLA SKLTTLFSTG QAARSGSSSS PISLSTEKET SFLSPTASTS RKTSLFLGPS
     MARQPNILVH LQTSALTLSP TSTLNMSQEE PPELTSSQTI AEEEGTTAET QTLTFTPSET
     PTSLLPVSSP TEPTARRKSS PETWASSISV PAKTSLVETT DGTLVTTIKM SSQAAQGNST
     WPAPAEETGS SPAGTSPGSP EMSTTLKIMS SKEPSISPEI RSTVRNSPWK TPETTVPMET
     TVEPVTLQST ALGSGSTSIS HLPTGTTSPT KSPTENMLAT ERVSLSPSPP EAWTNLYSGT
     PGGTRQSLAT MSSVSLESPT ARSITGTGQQ SSPELVSKTT GMEFSMWHGS TGGTTGDTHV
     SLSTSSNILE DPVTSPNSVS SLTDKSKHKT ETWVSTTAIP STVLNNKIMA AEQQTSRSVD
     EAYSSTSSWS DQTSGSDITL GASPDVTNTL YITSTAQTTS LVSLPSGDQG ITSLTNPSGG
     KTSSASSVTS PSIGLETLRA NVSAVKSDIA PTAGHLSQTS SPAEVSILDV TTAPTPGIST
     TITTMGTNSI STTTPNPEVG MSTMDSTPAT ERRTTSTEHP STWSSTAASD SWTVTDMTSN
     LKVARSPGTI STMHTTSFLA SSTELDSMST PHGRITVIGT SLVTPSSDAS AVKTETSTSE
     RTLSPSDTTA STPISTFSRV QRMSISVPDI LSTSWTPSST EAEDVPVSMV STDHASTKTD
     PNTPLSTFLF DSLSTLDWDT GRSLSSATAT TSAPQGATTP QELTLETMIS PATSQLPFSI
     GHITSAVTPA AMARSSGVTF SRPDPTSKKA EQTSTQLPTT TSAHPGQVPR SAATTLDVIP
     HTAKTPDATF QRQGQTALTT EARATSDSWN EKEKSTPSAP WITEMMNSVS EDTIKEVTSS
     SSVLRTLNTL DINLESGTTS SPSWKSSPYE RIAPSESTTD KEAIHPSTNT VETTGWVTSS
     EHASHSTIPA HSASSKLTSP VVTTSTREQA IVSMSTTTWP ESTRARTEPN SFLTIELRDV
     SPYMDTSSTT QTSIISSPGS TAITKGPRTE ITSSKRISSS FLAQSMRSSD SPSEAITRLS
     NFPAMTESGG MILAMQTSPP GATSLSAPTL DTSATASWTG TPLATTQRFT YSEKTTLFSK
     GPEDTSQPSP PSVEETSSSS SLVPIHATTS PSNILLTSQG HSPSSTPPVT SVFLSETSGL
     GKTTDMSRIS LEPGTSLPPN LSSTAGEALS TYEASRDTKA IHHSADTAVT NMEATSSEYS
     PIPGHTKPSK ATSPLVTSHI MGDITSSTSV FGSSETTEIE TVSSVNQGLQ ERSTSQVASS
     ATETSTVITH VSSGDATTHV TKTQATFSSG TSISSPHQFI TSTNTFTDVS TNPSTSLIMT
     ESSGVTITTQ TGPTGAATQG PYLLDTSTMP YLTETPLAVT PDFMQSEKTT LISKGPKDVS
     WTSPPSVAET SYPSSLTPFL VTTIPPATST LQGQHTSSPV SATSVLTSGL VKTTDMLNTS
     MEPVTNSPQN LNNPSNEILA TLAATTDIET IHPSINKAVT NMGTASSAHV LHSTLPVSSE
     PSTATSPMVP ASSMGDALAS ISIPGSETTD IEGEPTSSLT AGRKENSTLQ EMNSTTESNI
     ILSNVSVGAI TEATKMEVPS FDATFIPTPA QSTKFPDIFS VASSRLSNSP PMTISTHMTT
     TQTGSSGATS KIPLALDTST LETSAGTPSV VTEGFAHSKI TTAMNNDVKD VSQTNPPFQD
     EASSPSSQAP VLVTTLPSSV AFTPQWHSTS SPVSMSSVLT SSLVKTAGKV DTSLETVTSS
     PQSMSNTLDD ISVTSAATTD IETTHPSINT VVTNVGTTGS AFESHSTVSA YPEPSKVTSP
     NVTTSTMEDT TISRSIPKSS KTTRTETETT SSLTPKLRET SISQEITSST ETSTVPYKEL
     TGATTEVSRT DVTSSSSTSF PGPDQSTVSL DISTETNTRL STSPIMTESA EITITTQTGP
     HGATSQDTFT MDPSNTTPQA GIHSAMTHGF SQLDVTTLMS RIPQDVSWTS PPSVDKTSSP
     SSFLSSPAMT TPSLISSTLP EDKLSSPMTS LLTSGLVKIT DILRTRLEPV TSSLPNFSST
     SDKILATSKD SKDTKEIFPS INTEETNVKA NNSGHESHSP ALADSETPKA TTQMVITTTV
     GDPAPSTSMP VHGSSETTNI KREPTYFLTP RLRETSTSQE SSFPTDTSFL LSKVPTGTIT
     EVSSTGVNSS SKISTPDHDK STVPPDTFTG EIPRVFTSSI KTKSAEMTIT TQASPPESAS
     HSTLPLDTST TLSQGGTHST VTQGFPYSEV TTLMGMGPGN VSWMTTPPVE ETSSVSSLMS
     SPAMTSPSPV SSTSPQSIPS SPLPVTALPT SVLVTTTDVL GTTSPESVTS SPPNLSSITH
     ERPATYKDTA HTEAAMHHST NTAVTNVGTS GSGHKSQSSV LADSETSKAT PLMSTTSTLG
     DTSVSTSTPN ISQTNQIQTE PTASLSPRLR ESSTSEKTSS TTETNTAFSY VPTGAITQAS
     RTEISSSRTS ISDLDRPTIA PDISTGMITR LFTSPIMTKS AEMTVTTQTT TPGATSQGIL
     PWDTSTTLFQ GGTHSTVSQG FPHSEITTLR SRTPGDVSWM TTPPVEETSS GFSLMSPSMT
     SPSPVSSTSP ESIPSSPLPV TALLTSVLVT TTNVLGTTSP EPVTSSPPNL SSPTQERLTT
     YKDTAHTEAM HASMHTNTAV ANVGTSISGH ESQSSVPADS HTSKATSPMG ITFAMGDTSV
     STSTPAFFET RIQTESTSSL IPGLRDTRTS EEINTVTETS TVLSEVPTTT TTEVSRTEVI
     TSSRTTISGP DHSKMSPYIS TETITRLSTF PFVTGSTEMA ITNQTGPIGT ISQATLTLDT
     SSTASWEGTH SPVTQRFPHS EETTTMSRST KGVSWQSPPS VEETSSPSSP VPLPAITSHS
     SLYSAVSGSS PTSALPVTSL LTSGRRKTID MLDTHSELVT SSLPSASSFS GEILTSEAST
     NTETIHFSEN TAETNMGTTN SMHKLHSSVS IHSQPSGHTP PKVTGSMMED AIVSTSTPGS
     PETKNVDRDS TSPLTPELKE DSTALVMNST TESNTVFSSV SLDAATEVSR AEVTYYDPTF
     MPASAQSTKS PDISPEASSS HSNSPPLTIS THKTIATQTG PSGVTSLGQL TLDTSTIATS
     AGTPSARTQD FVDSETTSVM NNDLNDVLKT SPFSAEEANS LSSQAPLLVT TSPSPVTSTL
     QEHSTSSLVS VTSVPTPTLA KITDMDTNLE PVTRSPQNLR NTLATSEATT DTHTMHPSIN
     TAVANVGTTS SPNEFYFTVS PDSDPYKATS AVVITSTSGD SIVSTSMPRS SAMKKIESET
     TFSLIFRLRE TSTSQKIGSS SDTSTVFDKA FTAATTEVSR TELTSSSRTS IQGTEKPTMS
     PDTSTRSVTM LSTFAGLTKS EERTIATQTG PHRATSQGTL TWDTSITTSQ AGTHSAMTHG
     FSQLDLSTLT SRVPEYISGT SPPSVEKTSS SSSLLSLPAI TSPSPVPTTL PESRPSSPVH
     LTSLPTSGLV KTTDMLASVA SLPPNLGSTS HKIPTTSEDI KDTEKMYPST NIAVTNVGTT
     TSEKESYSSV PAYSEPPKVT SPMVTSFNIR DTIVSTSMPG SSEITRIEME STFSLAHGLK
     GTSTSQDPIV STEKSAVLHK LTTGATETSR TEVASSRRTS IPGPDHSTES PDISTEVIPS
     LPISLGITES SNMTIITRTG PPLGSTSQGT FTLDTPTTSS RAGTHSMATQ EFPHSEMTTV
     MNKDPEILSW TIPPSIEKTS FSSSLMPSPA MTSPPVSSTL PKTIHTTPSP MTSLLTPSLV
     MTTDTLGTSP EPTTSSPPNL SSTSHEILTT DEDTTAIEAM HPSTSTAATN VETTSSGHGS
     QSSVLADSEK TKATAPMDTT STMGHTTVST SMSVSSETTK IKRESTYSLT PGLRETSISQ
     NASFSTDTSI VLSEVPTGTT AEVSRTEVTS SGRTSIPGPS QSTVLPEIST RTMTRLFASP
     TMTESAEMTI PTQTGPSGST SQDTLTLDTS TTKSQAKTHS TLTQRFPHSE MTTLMSRGPG
     DMSWQSSPSL ENPSSLPSLL SLPATTSPPP ISSTLPVTIS SSPLPVTSLL TSSPVTTTDM
     LHTSPELVTS SPPKLSHTSD ERLTTGKDTT NTEAVHPSTN TAASNVEIPS SGHESPSSAL
     ADSETSKATS PMFITSTQED TTVAISTPHF LETSRIQKES ISSLSPKLRE TGSSVETSSA
     IETSAVLSEV SIGATTEISR TEVTSSSRTS ISGSAESTML PEISTTRKII KFPTSPILAE
     SSEMTIKTQT SPPGSTSEST FTLDTSTTPS LVITHSTMTQ RLPHSEITTL VSRGAGDVPR
     PSSLPVEETS PPSSQLSLSA MISPSPVSST LPASSHSSSA SVTSLLTPGQ VKTTEVLDAS
     AEPETSSPPS LSSTSVEILA TSEVTTDTEK IHPFSNTAVT KVGTSSSGHE SPSSVLPDSE
     TTKATSAMGT ISIMGDTSVS TLTPALSNTR KIQSEPASSL TTRLRETSTS EETSLATEAN
     TVLSKVSTGA TTEVSRTEAI SFSRTSMSGP EQSTMSQDIS IGTIPRISAS SVLTESAKMT
     ITTQTGPSES TLESTLNLNT ATTPSWVETH SIVIQGFPHP EMTTSMGRGP GGVSWPSPPF
     VKETSPPSSP LSLPAVTSPH PVSTTFLAHI PPSPLPVTSL LTSGPATTTD ILGTSTEPGT
     SSSSSLSTTS HERLTTYKDT AHTEAVHPST NTGGTNVATT SSGYKSQSSV LADSSPMCTT
     STMGDTSVLT STPAFLETRR IQTELASSLT PGLRESSGSE GTSSGTKMST VLSKVPTGAT
     TEISKEDVTS IPGPAQSTIS PDISTRTVSW FSTSPVMTES AEITMNTHTS PLGATTQGTS
     TLDTSSTTSL TMTHSTISQG FSHSQMSTLM RRGPEDVSWM SPPLLEKTRP SFSLMSSPAT
     TSPSPVSSTL PESISSSPLP VTSLLTSGLA KTTDMLHKSS EPVTNSPANL SSTSVEILAT
     SEVTTDTEKT HPSSNRTVTD VGTSSSGHES TSFVLADSQT SKVTSPMVIT STMEDTSVST
     STPGFFETSR IQTEPTSSLT LGLRKTSSSE GTSLATEMST VLSGVPTGAT AEVSRTEVTS
     SSRTSISGFA QLTVSPETST ETITRLPTSS IMTESAEMMI KTQTDPPGST PESTHTVDIS
     TTPNWVETHS TVTQRFSHSE MTTLVSRSPG DMLWPSQSSV EETSSASSLL SLPATTSPSP
     VSSTLVEDFP SASLPVTSLL NPGLVITTDR MGISREPGTS STSNLSSTSH ERLTTLEDTV
     DTEDMQPSTH TAVTNVRTSI SGHESQSSVL SDSETPKATS PMGTTYTMGE TSVSISTSDF
     FETSRIQIEP TSSLTSGLRE TSSSERISSA TEGSTVLSEV PSGATTEVSR TEVISSRGTS
     MSGPDQFTIS PDISTEAITR LSTSPIMTES AESAITIETG SPGATSEGTL TLDTSTTTFW
     SGTHSTASPG FSHSEMTTLM SRTPGDVPWP SLPSVEEASS VSSSLSSPAM TSTSFFSTLP
     ESISSSPHPV TALLTLGPVK TTDMLRTSSE PETSSPPNLS STSAEILATS EVTKDREKIH
     PSSNTPVVNV GTVIYKHLSP SSVLADLVTT KPTSPMATTS TLGNTSVSTS TPAFPETMMT
     QPTSSLTSGL REISTSQETS SATERSASLS GMPTGATTKV SRTEALSLGR TSTPGPAQST
     ISPEISTETI TRISTPLTTT GSAEMTITPK TGHSGASSQG TFTLDTSSRA SWPGTHSAAT
     HRSPHSGMTT PMSRGPEDVS WPSRPSVEKT SPPSSLVSLS AVTSPSPLYS TPSESSHSSP
     LRVTSLFTPV MMKTTDMLDT SLEPVTTSPP SMNITSDESL ATSKATMETE AIQLSENTAV
     TQMGTISARQ EFYSSYPGLP EPSKVTSPVV TSSTIKDIVS TTIPASSEIT RIEMESTSTL
     TPTPRETSTS QEIHSATKPS TVPYKALTSA TIEDSMTQVM SSSRGPSPDQ STMSQDISTE
     VITRLSTSPI KTESTEMTIT TQTGSPGATS RGTLTLDTST TFMSGTHSTA SQGFSHSQMT
     ALMSRTPGDV PWLSHPSVEE ASSASFSLSS PVMTSSSPVS STLPDSIHSS SLPVTSLLTS
     GLVKTTELLG TSSEPETSSP PNLSSTSAEI LAITEVTTDT EKLEMTNVVT SGYTHESPSS
     VLADSVTTKA TSSMGITYPT GDTNVLTSTP AFSDTSRIQT KSKLSLTPGL METSISEETS
     SATEKSTVLS SVPTGATTEV SRTEAISSSR TSIPGPAQST MSSDTSMETI TRISTPLTRK
     ESTDMAITPK TGPSGATSQG TFTLDSSSTA SWPGTHSATT QRFPQSVVTT PMSRGPEDVS
     WPSPLSVEKN SPPSSLVSSS SVTSPSPLYS TPSGSSHSSP VPVTSLFTSI MMKATDMLDA
     SLEPETTSAP NMNITSDESL AASKATTETE AIHVFENTAA SHVETTSATE ELYSSSPGFS
     EPTKVISPVV TSSSIRDNMV STTMPGSSGI TRIEIESMSS LTPGLRETRT SQDITSSTET
     STVLYKMPSG ATPEVSRTEV MPSSRTSIPG PAQSTMSLDI SDEVVTRLST SPIMTESAEI
     TITTQTGYSL ATSQVTLPLG TSMTFLSGTH STMSQGLSHS EMTNLMSRGP ESLSWTSPRF
     VETTRSSSSL TSLPLTTSLS PVSSTLLDSS PSSPLPVTSL ILPGLVKTTE VLDTSSEPKT
     SSSPNLSSTS VEIPATSEIM TDTEKIHPSS NTAVAKVRTS SSVHESHSSV LADSETTITI
     PSMGITSAVD DTTVFTSNPA FSETRRIPTE PTFSLTPGFR ETSTSEETTS ITETSAVLYG
     VPTSATTEVS MTEIMSSNRI HIPDSDQSTM SPDIITEVIT RLSSSSMMSE STQMTITTQK
     SSPGATAQST LTLATTTAPL ARTHSTVPPR FLHSEMTTLM SRSPENPSWK SSLFVEKTSS
     SSSLLSLPVT TSPSVSSTLP QSIPSSSFSV TSLLTPGMVK TTDTSTEPGT SLSPNLSGTS
     VEILAASEVT TDTEKIHPSS SMAVTNVGTT SSGHELYSSV SIHSEPSKAT YPVGTPSSMA
     ETSISTSMPA NFETTGFEAE PFSHLTSGFR KTNMSLDTSS VTPTNTPSSP GSTHLLQSSK
     TDFTSSAKTS SPDWPPASQY TEIPVDIITP FNASPSITES TGITSFPESR FTMSVTESTH
     HLSTDLLPSA ETISTGTVMP SLSEAMTSFA TTGVPRAISG SGSPFSRTES GPGDATLSTI
     AESLPSSTPV PFSSSTFTTT DSSTIPALHE ITSSSATPYR VDTSLGTESS TTEGRLVMVS
     TLDTSSQPGR TSSSPILDTR MTESVELGTV TSAYQVPSLS TRLTRTDGIM EHITKIPNEA
     AHRGTIRPVK GPQTSTSPAS PKGLHTGGTK RMETTTTALK TTTTALKTTS RATLTTSVYT
     PTLGTLTPLN ASMQMASTIP TEMMITTPYV FPDVPETTSS LATSLGAETS TALPRTTPSV
     FNRESETTAS LVSRSGAERS PVIQTLDVSS SEPDTTASWV IHPAETIPTV SKTTPNFFHS
     ELDTVSSTAT SHGADVSSAI PTNISPSELD ALTPLVTISG TDTSTTFPTL TKSPHETETR
     TTWLTHPAET SSTIPRTIPN FSHHESDATP SIATSPGAET SSAIPIMTVS PGAEDLVTSQ
     VTSSGTDRNM TIPTLTLSPG EPKTIASLVT HPEAQTSSAI PTSTISPAVS RLVTSMVTSL
     AAKTSTTNRA LTNSPGEPAT TVSLVTHPAQ TSPTVPWTTS IFFHSKSDTT PSMTTSHGAE
     SSSAVPTPTV STEVPGVVTP LVTSSRAVIS TTIPILTLSP GEPETTPSMA TSHGEEASSA
     IPTPTVSPGV PGVVTSLVTS SRAVTSTTIP ILTFSLGEPE TTPSMATSHG TEAGSAVPTV
     LPEVPGMVTS LVASSRAVTS TTLPTLTLSP GEPETTPSMA TSHGAEASST VPTVSPEVPG
     VVTSLVTSSS GVNSTSIPTL ILSPGELETT PSMATSHGAE ASSAVPTPTV SPGVSGVVTP
     LVTSSRAVTS TTIPILTLSS SEPETTPSMA TSHGVEASSA VLTVSPEVPG MVTSLVTSSR
     AVTSTTIPTL TISSDEPETT TSLVTHSEAK MISAIPTLAV SPTVQGLVTS LVTSSGSETS
     AFSNLTVASS QPETIDSWVA HPGTEASSVV PTLTVSTGEP FTNISLVTHP AESSSTLPRT
     TSRFSHSELD TMPSTVTSPE AESSSAISTT ISPGIPGVLT SLVTSSGRDI SATFPTVPES
     PHESEATASW VTHPAVTSTT VPRTTPNYSH SEPDTTPSIA TSPGAEATSD FPTITVSPDV
     PDMVTSQVTS SGTDTSITIP TLTLSSGEPE TTTSFITYSE THTSSAIPTL PVSPGASKML
     TSLVISSGTD STTTFPTLTE TPYEPETTAI QLIHPAETNT MVPRTTPKFS HSKSDTTLPV
     AITSPGPEAS SAVSTTTISP DMSDLVTSLV PSSGTDTSTT FPTLSETPYE PETTATWLTH
     PAETSTTVSG TIPNFSHRGS DTAPSMVTSP GVDTRSGVPT TTIPPSIPGV VTSQVTSSAT
     DTSTAIPTLT PSPGEPETTA SSATHPGTQT GFTVPIRTVP SSEPDTMASW VTHPPQTSTP
     VSRTTSSFSH SSPDATPVMA TSPRTEASSA VLTTISPGAP EMVTSQITSS GAATSTTVPT
     LTHSPGMPET TALLSTHPRT ETSKTFPAST VFPQVSETTA SLTIRPGAET STALPTQTTS
     SLFTLLVTGT SRVDLSPTAS PGVSAKTAPL STHPGTETST MIPTSTLSLG LLETTGLLAT
     SSSAETSTST LTLTVSPAVS GLSSASITTD KPQTVTSWNT ETSPSVTSVG PPEFSRTVTG
     TTMTLIPSEM PTPPKTSHGE GVSPTTILRT TMVEATNLAT TGSSPTVAKT TTTFNTLAGS
     LFTPLTTPGM STLASESVTS RTSYNHRSWI STTSSYNRRY WTPATSTPVT STFSPGISTS
     SIPSSTAATV PFMVPFTLNF TITNLQYEED MRHPGSRKFN ATERELQGLL KPLFRNSSLE
     YLYSGCRLAS LRPEKDSSAT AVDAICTHRP DPEDLGLDRE RLYWELSNLT NGIQELGPYT
     LDRNSLYVNG FTHRSSMPTT STPGTSTVDV GTSGTPSSSP SPTTAGPLLM PFTLNFTITN
     LQYEEDMRRT GSRKFNTMES VLQGLLKPLF KNTSVGPLYS GCRLTLLRPE KDGAATGVDA
     ICTHRLDPKS PGLNREQLYW ELSKLTNDIE ELGPYTLDRN SLYVNGFTHQ SSVSTTSTPG
     TSTVDLRTSG TPSSLSSPTI MAAGPLLVPF TLNFTITNLQ YGEDMGHPGS RKFNTTERVL
     QGLLGPIFKN TSVGPLYSGC RLTSLRSEKD GAATGVDAIC IHHLDPKSPG LNRERLYWEL
     SQLTNGIKEL GPYTLDRNSL YVNGFTHRTS VPTSSTPGTS TVDLGTSGTP FSLPSPATAG
     PLLVLFTLNF TITNLKYEED MHRPGSRKFN TTERVLQTLL GPMFKNTSVG LLYSGCRLTL
     LRSEKDGAAT GVDAICTHRL DPKSPGVDRE QLYWELSQLT NGIKELGPYT LDRNSLYVNG
     FTHWIPVPTS STPGTSTVDL GSGTPSSLPS PTTAGPLLVP FTLNFTITNL KYEEDMHCPG
     SRKFNTTERV LQSLLGPMFK NTSVGPLYSG CRLTLLRSEK DGAATGVDAI CTHRLDPKSP
     GVDREQLYWE LSQLTNGIKE LGPYTLDRNS LYVNGFTHQT SAPNTSTPGT STVDLGTSGT
     PSSLPSPTSA GPLLVPFTLN FTITNLQYEE DMHHPGSRKF NTTERVLQGL LGPMFKNTSV
     GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLNR EQLYWELSQL THGIKELGPY
     TLDRNSLYVN GFTHRSSVAP TSTPGTSTVD LGTSGTPSSL PSPTTAVPLL VPFTLNFTIT
     NLQYGEDMRH PGSRKFNTTE RVLQGLLGPL FKNSSVGPLY SGCRLISLRS EKDGAATGVD
     AICTHHLNPQ SPGLDREQLY WQLSQMTNGI KELGPYTLDR NSLYVNGFTH RSSGLTTSTP
     WTSTVDLGTS GTPSPVPSPT TTGPLLVPFT LNFTITNLQY EENMGHPGSR KFNITESVLQ
     GLLKPLFKST SVGPLYSGCR LTLLRPEKDG VATRVDAICT HRPDPKIPGL DRQQLYWELS
     QLTHSITELG PYTLDRDSLY VNGFTQRSSV PTTSTPGTFT VQPETSETPS SLPGPTATGP
     VLLPFTLNFT ITNLQYEEDM RRPGSRKFNT TERVLQGLLM PLFKNTSVSS LYSGCRLTLL
     RPEKDGAATR VDAVCTHRPD PKSPGLDRER LYWKLSQLTH GITELGPYTL DRHSLYVNGF
     THQSSMTTTR TPDTSTMHLA TSRTPASLSG PMTASPLLVL FTINFTITNL RYEENMHHPG
     SRKFNTTERV LQGLLRPVFK NTSVGPLYSG CRLTLLRPKK DGAATKVDAI CTYRPDPKSP
     GLDREQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSIPGT PTVDLGTSGT
     PVSKPGPSAA SPLLVLFTLN FTITNLRYEE NMQHPGSRKF NTTERVLQGL LRSLFKSTSV
     GPLYSGCRLT LLRPEKDGTA TGVDAICTHH PDPKSPRLDR EQLYWELSQL THNITELGPY
     ALDNDSLFVN GFTHRSSVST TSTPGTPTVY LGASKTPASI FGPSAASHLL ILFTLNFTIT
     NLRYEENMWP GSRKFNTTER VLQGLLRPLF KNTSVGPLYS GCRLTLLRPE KDGEATGVDA
     ICTHRPDPTG PGLDREQLYL ELSQLTHSIT ELGPYTLDRD SLYVNGFTHR SSVPTTSTGV
     VSEEPFTLNF TINNLRYMAD MGQPGSLKFN ITDNVMQHLL SPLFQRSSLG ARYTGCRVIA
     LRSVKNGAET RVDLLCTYLQ PLSGPGLPIK QVFHELSQQT HGITRLGPYS LDKDSLYLNG
     YNEPGPDEPP TTPKPATTFL PPLSEATTAM GYHLKTLTLN FTISNLQYSP DMGKGSATFN
     STEGVLQHLL RPLFQKSSMG PFYLGCQLIS LRPEKDGAAT GVDTTCTYHP DPVGPGLDIQ
     QLYWELSQLT HGVTQLGFYV LDRDSLFING YAPQNLSIRG EYQINFHIVN WNLSNPDPTS
     SEYITLLRDI QDKVTTLYKG SQLHDTFRFC LVTNLTMDSV LVTVKALFSS NLDPSLVEQV
     FLDKTLNASF HWLGSTYQLV DIHVTEMESS VYQPTSSSST QHFYLNFTIT NLPYSQDKAQ
     PGTTNYQRNK RNIEDALNQL FRNSSIKSYF SDCQVSTFRS VPNRHHTGVD SLCNFSPLAR
     RVDRVAIYEE FLRMTRNGTQ LQNFTLDRSS VLVDGYSPNR NEPLTGNSDL PFWAVILIGL
     AGLLGVITCL ICGVLVTTRR RKKEGEYNVQ QQCPGYYQSH LDLEDLQ
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