Q8WXI7 (MUC16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mucin-16
Short name=MUC-16

Alternative name(s):
Ovarian cancer-related tumor marker CA125
Short name=CA-125
Ovarian carcinoma antigen CA125

Gene names

Name:	MUC16
Synonyms:	CA125

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	22152 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces By similarity.
Subunit structure	Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN. Ref.8
Subcellular location	Cell membrane; Single-pass type I membrane protein. Secreted › extracellular space. Note: May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
Tissue specificity	Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. Ref.1 Ref.3 Ref.10
Induction	Up-regulated in ovarian cancer cells. Ref.1
Domain	Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.
Post-translational modification	Heavily O-glycosylated; expresses both type 1 and type 2 core glycans. Ref.7 Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans. Ref.7 May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. Ref.6 May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
Polymorphism	The number of repeats is highly polymorphic.
Miscellaneous	Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.
Sequence similarities	Contains 2 ANK repeats. Contains 56 SEA domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	O-glycan processing Traceable author statement. Source: Reactome cell adhesion Non-traceable author statement Ref.8. Source: UniProtKB post-translational protein modification Traceable author statement. Source: Reactome
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membrane Inferred from direct assay PubMed 12766047. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 22152	22152	Mucin-16		PRO_0000259595
Regions
	Topological domain	1 – 22096	22096	Extracellular Potential
	Transmembrane	22097 – 22117	21	Helical; Potential
	Topological domain	22118 – 22152	35	Cytoplasmic Potential
	Domain	12070 – 12190	121	SEA 1
	Domain	12229 – 12339	111	SEA 2
	Domain	12386 – 12504	119	SEA 3
	Domain	12539 – 12660	122	SEA 4
	Domain	12697 – 12815	119	SEA 5
	Domain	12853 – 12971	119	SEA 6
	Domain	13009 – 13127	119	SEA 7
	Domain	13165 – 13283	119	SEA 8
	Domain	13315 – 13439	125	SEA 9
	Domain	13477 – 13595	119	SEA 10
	Domain	13633 – 13751	119	SEA 11
	Repeat	13767 – 13801	35	ANK 1
	Domain	13789 – 13907	119	SEA 12
	Domain	13939 – 14063	125	SEA 13
	Domain	14101 – 14219	119	SEA 14
	Domain	14251 – 14375	125	SEA 15
	Domain	14410 – 14531	122	SEA 16
	Domain	14567 – 14689	123	SEA 17
	Domain	14723 – 14845	123	SEA 18
	Domain	14877 – 15001	125	SEA 19
	Domain	15039 – 15157	119	SEA 20
	Domain	15195 – 15313	119	SEA 21
	Domain	15348 – 15469	122	SEA 22
	Domain	15507 – 15625	119	SEA 23
	Domain	15664 – 15774	111	SEA 24
	Domain	15812 – 15936	125	SEA 25
	Domain	16123 – 16247	125	SEA 26
	Domain	16279 – 16403	125	SEA 27
	Domain	16437 – 16559	123	SEA 28
	Domain	16591 – 16715	125	SEA 29
	Domain	16750 – 16871	122	SEA 30
	Domain	16905 – 17027	123	SEA 31
	Domain	17065 – 17183	119	SEA 32
	Domain	17221 – 17339	119	SEA 33
	Domain	17378 – 17488	111	SEA 34
	Domain	17534 – 17644	111	SEA 35
	Domain	17689 – 17807	119	SEA 36
	Domain	18001 – 18119	119	SEA 37
	Domain	18313 – 18431	119	SEA 38
	Domain	18625 – 18743	119	SEA 39
	Repeat	18915 – 18949	35	ANK 2
	Domain	18937 – 19055	119	SEA 40
	Domain	19243 – 19367	125	SEA 41
	Domain	19555 – 19679	125	SEA 42
	Domain	19866 – 19990	125	SEA 43
	Domain	20184 – 20302	119	SEA 44
	Domain	20340 – 20458	119	SEA 45
	Domain	20496 – 20614	119	SEA 46
	Domain	20652 – 20770	119	SEA 47
	Domain	20804 – 20926	123	SEA 48
	Domain	20964 – 21082	119	SEA 49
	Domain	21117 – 21238	122	SEA 50
	Domain	21273 – 21394	122	SEA 51
	Domain	21433 – 21542	110	SEA 52
	Domain	21565 – 21683	119	SEA 53
	Domain	21717 – 21826	110	SEA 54
	Domain	21836 – 21957	122	SEA 55
	Domain	21959 – 22080	122	SEA 56
	Compositional bias	14 – 12085	12072	Thr-rich
	Compositional bias	1638 – 3055	1418	Ser-rich
	Compositional bias	3961 – 4385	425	Ser-rich
	Compositional bias	7085 – 10395	3311	Ser-rich
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
	Glycosylation	434	1	N-linked (GlcNAc...) Potential
	Glycosylation	787	1	N-linked (GlcNAc...) Potential
	Glycosylation	930	1	N-linked (GlcNAc...) Potential
	Glycosylation	957	1	N-linked (GlcNAc...) Potential
	Glycosylation	1375	1	N-linked (GlcNAc...) Potential
	Glycosylation	1633	1	N-linked (GlcNAc...) Potential
	Glycosylation	1840	1	N-linked (GlcNAc...) Potential
	Glycosylation	1877	1	N-linked (GlcNAc...) Potential
	Glycosylation	1890	1	N-linked (GlcNAc...) Potential
	Glycosylation	2345	1	N-linked (GlcNAc...) Potential
	Glycosylation	2375	1	N-linked (GlcNAc...) Potential
	Glycosylation	2737	1	N-linked (GlcNAc...) Potential
	Glycosylation	3086	1	N-linked (GlcNAc...) Potential
	Glycosylation	3179	1	N-linked (GlcNAc...) Potential
	Glycosylation	3502	1	N-linked (GlcNAc...) Potential
	Glycosylation	4222	1	N-linked (GlcNAc...) Potential
	Glycosylation	4500	1	N-linked (GlcNAc...) Potential
	Glycosylation	4608	1	N-linked (GlcNAc...) Potential
	Glycosylation	4615	1	N-linked (GlcNAc...) Potential
	Glycosylation	4626	1	N-linked (GlcNAc...) Potential
	Glycosylation	4863	1	N-linked (GlcNAc...) Potential
	Glycosylation	5098	1	N-linked (GlcNAc...) Potential
	Glycosylation	5133	1	N-linked (GlcNAc...) Potential
	Glycosylation	5230	1	N-linked (GlcNAc...) Potential
	Glycosylation	5322	1	N-linked (GlcNAc...) Potential
	Glycosylation	5396	1	N-linked (GlcNAc...) Potential
	Glycosylation	5472	1	N-linked (GlcNAc...) Potential
	Glycosylation	5691	1	N-linked (GlcNAc...) Potential
	Glycosylation	5865	1	N-linked (GlcNAc...) Potential
	Glycosylation	6090	1	N-linked (GlcNAc...) Potential
	Glycosylation	6734	1	N-linked (GlcNAc...) Potential
	Glycosylation	6861	1	N-linked (GlcNAc...) Potential
	Glycosylation	6963	1	N-linked (GlcNAc...) Potential
	Glycosylation	8031	1	N-linked (GlcNAc...) Potential
	Glycosylation	8057	1	N-linked (GlcNAc...) Potential
	Glycosylation	8326	1	N-linked (GlcNAc...) Potential
	Glycosylation	8620	1	N-linked (GlcNAc...) Potential
	Glycosylation	8686	1	N-linked (GlcNAc...) Potential
	Glycosylation	8915	1	N-linked (GlcNAc...) Potential
	Glycosylation	9204	1	N-linked (GlcNAc...) Potential
	Glycosylation	9495	1	N-linked (GlcNAc...) Potential
	Glycosylation	9787	1	N-linked (GlcNAc...) Potential
	Glycosylation	9920	1	N-linked (GlcNAc...) Potential
	Glycosylation	10077	1	N-linked (GlcNAc...) Potential
	Glycosylation	10175	1	N-linked (GlcNAc...) Potential
	Glycosylation	10512	1	N-linked (GlcNAc...) Potential
	Glycosylation	10702	1	N-linked (GlcNAc...) Potential
	Glycosylation	10751	1	N-linked (GlcNAc...) Potential
	Glycosylation	11055	1	N-linked (GlcNAc...) Potential
	Glycosylation	11226	1	N-linked (GlcNAc...) Potential
	Glycosylation	11265	1	N-linked (GlcNAc...) Potential
	Glycosylation	11369	1	N-linked (GlcNAc...) Potential
	Glycosylation	11596	1	N-linked (GlcNAc...) Potential
	Glycosylation	12081	1	N-linked (GlcNAc...) Potential
	Glycosylation	12102	1	N-linked (GlcNAc...) Potential
	Glycosylation	12118	1	N-linked (GlcNAc...) Potential
	Glycosylation	12170	1	N-linked (GlcNAc...) Potential
	Glycosylation	12237	1	N-linked (GlcNAc...) Potential
	Glycosylation	12274	1	N-linked (GlcNAc...) Potential
	Glycosylation	12395	1	N-linked (GlcNAc...) Potential
	Glycosylation	12416	1	N-linked (GlcNAc...) Potential
	Glycosylation	12432	1	N-linked (GlcNAc...) Potential
	Glycosylation	12551	1	N-linked (GlcNAc...) Potential
	Glycosylation	12572	1	N-linked (GlcNAc...) Potential
	Glycosylation	12588	1	N-linked (GlcNAc...) Potential
	Glycosylation	12706	1	N-linked (GlcNAc...) Potential
	Glycosylation	12727	1	N-linked (GlcNAc...) Potential
	Glycosylation	12743	1	N-linked (GlcNAc...) Potential
	Glycosylation	12826	1	N-linked (GlcNAc...) Potential
	Glycosylation	12862	1	N-linked (GlcNAc...) Potential
	Glycosylation	12883	1	N-linked (GlcNAc...) Potential
	Glycosylation	12982	1	N-linked (GlcNAc...) Potential
	Glycosylation	13018	1	N-linked (GlcNAc...) Potential
	Glycosylation	13039	1	N-linked (GlcNAc...) Potential
	Glycosylation	13055	1	N-linked (GlcNAc...) Potential
	Glycosylation	13174	1	N-linked (GlcNAc...) Potential
	Glycosylation	13195	1	N-linked (GlcNAc...) Potential
	Glycosylation	13211	1	N-linked (GlcNAc...) Potential
	Glycosylation	13330	1	N-linked (GlcNAc...) Potential
	Glycosylation	13351	1	N-linked (GlcNAc...) Potential
	Glycosylation	13367	1	N-linked (GlcNAc...) Potential
	Glycosylation	13423	1	N-linked (GlcNAc...) Potential
	Glycosylation	13486	1	N-linked (GlcNAc...) Potential
	Glycosylation	13507	1	N-linked (GlcNAc...) Potential
	Glycosylation	13523	1	N-linked (GlcNAc...) Potential
	Glycosylation	13579	1	N-linked (GlcNAc...) Potential
	Glycosylation	13642	1	N-linked (GlcNAc...) Potential
	Glycosylation	13663	1	N-linked (GlcNAc...) Potential
	Glycosylation	13679	1	N-linked (GlcNAc...) Potential
	Glycosylation	13798	1	N-linked (GlcNAc...) Potential
	Glycosylation	13819	1	N-linked (GlcNAc...) Potential
	Glycosylation	13835	1	N-linked (GlcNAc...) Potential
	Glycosylation	13954	1	N-linked (GlcNAc...) Potential
	Glycosylation	13975	1	N-linked (GlcNAc...) Potential
	Glycosylation	13991	1	N-linked (GlcNAc...) Potential
	Glycosylation	14110	1	N-linked (GlcNAc...) Potential
	Glycosylation	14131	1	N-linked (GlcNAc...) Potential
	Glycosylation	14147	1	N-linked (GlcNAc...) Potential
	Glycosylation	14266	1	N-linked (GlcNAc...) Potential
	Glycosylation	14287	1	N-linked (GlcNAc...) Potential
	Glycosylation	14303	1	N-linked (GlcNAc...) Potential
	Glycosylation	14359	1	N-linked (GlcNAc...) Potential
	Glycosylation	14422	1	N-linked (GlcNAc...) Potential
	Glycosylation	14459	1	N-linked (GlcNAc...) Potential
	Glycosylation	14580	1	N-linked (GlcNAc...) Potential
	Glycosylation	14601	1	N-linked (GlcNAc...) Potential
	Glycosylation	14617	1	N-linked (GlcNAc...) Potential
	Glycosylation	14736	1	N-linked (GlcNAc...) Potential
	Glycosylation	14757	1	N-linked (GlcNAc...) Potential
	Glycosylation	14773	1	N-linked (GlcNAc...) Potential
	Glycosylation	14825	1	N-linked (GlcNAc...) Potential
	Glycosylation	14892	1	N-linked (GlcNAc...) Potential
	Glycosylation	14913	1	N-linked (GlcNAc...) Potential
	Glycosylation	14929	1	N-linked (GlcNAc...) Potential
	Glycosylation	15048	1	N-linked (GlcNAc...) Potential
	Glycosylation	15069	1	N-linked (GlcNAc...) Potential
	Glycosylation	15204	1	N-linked (GlcNAc...) Potential
	Glycosylation	15241	1	N-linked (GlcNAc...) Potential
	Glycosylation	15360	1	N-linked (GlcNAc...) Potential
	Glycosylation	15381	1	N-linked (GlcNAc...) Potential
	Glycosylation	15397	1	N-linked (GlcNAc...) Potential
	Glycosylation	15516	1	N-linked (GlcNAc...) Potential
	Glycosylation	15537	1	N-linked (GlcNAc...) Potential
	Glycosylation	15672	1	N-linked (GlcNAc...) Potential
	Glycosylation	15693	1	N-linked (GlcNAc...) Potential
	Glycosylation	15709	1	N-linked (GlcNAc...) Potential
	Glycosylation	15827	1	N-linked (GlcNAc...) Potential
	Glycosylation	15848	1	N-linked (GlcNAc...) Potential
	Glycosylation	15864	1	N-linked (GlcNAc...) Potential
	Glycosylation	15947	1	N-linked (GlcNAc...) Potential
	Glycosylation	15983	1	N-linked (GlcNAc...) Potential
	Glycosylation	16004	1	N-linked (GlcNAc...) Potential
	Glycosylation	16020	1	N-linked (GlcNAc...) Potential
	Glycosylation	16138	1	N-linked (GlcNAc...) Potential
	Glycosylation	16159	1	N-linked (GlcNAc...) Potential
	Glycosylation	16175	1	N-linked (GlcNAc...) Potential
	Glycosylation	16258	1	N-linked (GlcNAc...) Potential
	Glycosylation	16294	1	N-linked (GlcNAc...) Potential
	Glycosylation	16315	1	N-linked (GlcNAc...) Potential
	Glycosylation	16331	1	N-linked (GlcNAc...) Potential
	Glycosylation	16450	1	N-linked (GlcNAc...) Potential
	Glycosylation	16471	1	N-linked (GlcNAc...) Potential
	Glycosylation	16487	1	N-linked (GlcNAc...) Potential
	Glycosylation	16539	1	N-linked (GlcNAc...) Potential
	Glycosylation	16606	1	N-linked (GlcNAc...) Potential
	Glycosylation	16627	1	N-linked (GlcNAc...) Potential
	Glycosylation	16643	1	N-linked (GlcNAc...) Potential
	Glycosylation	16762	1	N-linked (GlcNAc...) Potential
	Glycosylation	16783	1	N-linked (GlcNAc...) Potential
	Glycosylation	16799	1	N-linked (GlcNAc...) Potential
	Glycosylation	16918	1	N-linked (GlcNAc...) Potential
	Glycosylation	16939	1	N-linked (GlcNAc...) Potential
	Glycosylation	16955	1	N-linked (GlcNAc...) Potential
	Glycosylation	17074	1	N-linked (GlcNAc...) Potential
	Glycosylation	17095	1	N-linked (GlcNAc...) Potential
	Glycosylation	17111	1	N-linked (GlcNAc...) Potential
	Glycosylation	17230	1	N-linked (GlcNAc...) Potential
	Glycosylation	17251	1	N-linked (GlcNAc...) Potential
	Glycosylation	17386	1	N-linked (GlcNAc...) Potential
	Glycosylation	17407	1	N-linked (GlcNAc...) Potential
	Glycosylation	17423	1	N-linked (GlcNAc...) Potential
	Glycosylation	17542	1	N-linked (GlcNAc...) Potential
	Glycosylation	17563	1	N-linked (GlcNAc...) Potential
	Glycosylation	17579	1	N-linked (GlcNAc...) Potential
	Glycosylation	17698	1	N-linked (GlcNAc...) Potential
	Glycosylation	17719	1	N-linked (GlcNAc...) Potential
	Glycosylation	17854	1	N-linked (GlcNAc...) Potential
	Glycosylation	17875	1	N-linked (GlcNAc...) Potential
	Glycosylation	17891	1	N-linked (GlcNAc...) Potential
	Glycosylation	18010	1	N-linked (GlcNAc...) Potential
	Glycosylation	18031	1	N-linked (GlcNAc...) Potential
	Glycosylation	18047	1	N-linked (GlcNAc...) Potential
	Glycosylation	18166	1	N-linked (GlcNAc...) Potential
	Glycosylation	18187	1	N-linked (GlcNAc...) Potential
	Glycosylation	18203	1	N-linked (GlcNAc...) Potential
	Glycosylation	18322	1	N-linked (GlcNAc...) Potential
	Glycosylation	18343	1	N-linked (GlcNAc...) Potential
	Glycosylation	18359	1	N-linked (GlcNAc...) Potential
	Glycosylation	18478	1	N-linked (GlcNAc...) Potential
	Glycosylation	18499	1	N-linked (GlcNAc...) Potential
	Glycosylation	18515	1	N-linked (GlcNAc...) Potential
	Glycosylation	18634	1	N-linked (GlcNAc...) Potential
	Glycosylation	18655	1	N-linked (GlcNAc...) Potential
	Glycosylation	18790	1	N-linked (GlcNAc...) Potential
	Glycosylation	18811	1	N-linked (GlcNAc...) Potential
	Glycosylation	18827	1	N-linked (GlcNAc...) Potential
	Glycosylation	18946	1	N-linked (GlcNAc...) Potential
	Glycosylation	18967	1	N-linked (GlcNAc...) Potential
	Glycosylation	18983	1	N-linked (GlcNAc...) Potential
	Glycosylation	19039	1	N-linked (GlcNAc...) Potential
	Glycosylation	19102	1	N-linked (GlcNAc...) Potential
	Glycosylation	19123	1	N-linked (GlcNAc...) Potential
	Glycosylation	19139	1	N-linked (GlcNAc...) Potential
	Glycosylation	19258	1	N-linked (GlcNAc...) Potential
	Glycosylation	19279	1	N-linked (GlcNAc...) Potential
	Glycosylation	19295	1	N-linked (GlcNAc...) Potential
	Glycosylation	19414	1	N-linked (GlcNAc...) Potential
	Glycosylation	19435	1	N-linked (GlcNAc...) Potential
	Glycosylation	19451	1	N-linked (GlcNAc...) Potential
	Glycosylation	19570	1	N-linked (GlcNAc...) Potential
	Glycosylation	19591	1	N-linked (GlcNAc...) Potential
	Glycosylation	19607	1	N-linked (GlcNAc...) Potential
	Glycosylation	19726	1	N-linked (GlcNAc...) Potential
	Glycosylation	19747	1	N-linked (GlcNAc...) Potential
	Glycosylation	19763	1	N-linked (GlcNAc...) Potential
	Glycosylation	19881	1	N-linked (GlcNAc...) Potential
	Glycosylation	19902	1	N-linked (GlcNAc...) Potential
	Glycosylation	19918	1	N-linked (GlcNAc...) Potential
	Glycosylation	20037	1	N-linked (GlcNAc...) Potential
	Glycosylation	20058	1	N-linked (GlcNAc...) Potential
	Glycosylation	20074	1	N-linked (GlcNAc...) Potential
	Glycosylation	20157	1	N-linked (GlcNAc...) Potential
	Glycosylation	20193	1	N-linked (GlcNAc...) Potential
	Glycosylation	20214	1	N-linked (GlcNAc...) Potential
	Glycosylation	20230	1	N-linked (GlcNAc...) Potential
	Glycosylation	20349	1	N-linked (GlcNAc...) Potential
	Glycosylation	20370	1	N-linked (GlcNAc...) Potential
	Glycosylation	20505	1	N-linked (GlcNAc...) Potential
	Glycosylation	20526	1	N-linked (GlcNAc...) Potential
	Glycosylation	20661	1	N-linked (GlcNAc...) Potential
	Glycosylation	20682	1	N-linked (GlcNAc...) Potential
	Glycosylation	20698	1	N-linked (GlcNAc...) Potential
	Glycosylation	20817	1	N-linked (GlcNAc...) Potential
	Glycosylation	20838	1	N-linked (GlcNAc...) Potential
	Glycosylation	20973	1	N-linked (GlcNAc...) Potential
	Glycosylation	20994	1	N-linked (GlcNAc...) Potential
	Glycosylation	21010	1	N-linked (GlcNAc...) Potential
	Glycosylation	21129	1	N-linked (GlcNAc...) Potential
	Glycosylation	21150	1	N-linked (GlcNAc...) Potential
	Glycosylation	21166	1	N-linked (GlcNAc...) Potential
	Glycosylation	21285	1	N-linked (GlcNAc...) Potential
	Glycosylation	21306	1	N-linked (GlcNAc...) Potential
	Glycosylation	21378	1	N-linked (GlcNAc...) Potential
	Glycosylation	21389	1	N-linked (GlcNAc...) Potential
	Glycosylation	21441	1	N-linked (GlcNAc...) Potential
	Glycosylation	21461	1	N-linked (GlcNAc...) Potential
	Glycosylation	21477	1	N-linked (GlcNAc...) Potential
	Glycosylation	21574	1	N-linked (GlcNAc...) Potential
	Glycosylation	21595	1	N-linked (GlcNAc...) Potential
	Glycosylation	21725	1	N-linked (GlcNAc...) Potential
	Glycosylation	21745	1	N-linked (GlcNAc...) Potential
	Glycosylation	21840	1	N-linked (GlcNAc...) Potential
	Glycosylation	21857	1	N-linked (GlcNAc...) Potential
	Glycosylation	21899	1	N-linked (GlcNAc...) Potential
	Glycosylation	21932	1	N-linked (GlcNAc...) Potential
	Glycosylation	21971	1	N-linked (GlcNAc...) Potential
	Glycosylation	22008	1	N-linked (GlcNAc...) Potential
	Glycosylation	22062	1	N-linked (GlcNAc...) Potential
	Glycosylation	22068	1	N-linked (GlcNAc...) Potential
	Disulfide bond	12128 ↔ 12148		Potential
	Disulfide bond	12284 ↔ 12304		Potential
	Disulfide bond	12442 ↔ 12462		Potential
	Disulfide bond	12598 ↔ 12618		Potential
	Disulfide bond	12753 ↔ 12773		Potential
	Disulfide bond	12909 ↔ 12929		Potential
	Disulfide bond	13065 ↔ 13085		Potential
	Disulfide bond	13221 ↔ 13241		Potential
	Disulfide bond	13377 ↔ 13397		Potential
	Disulfide bond	13533 ↔ 13553		Potential
	Disulfide bond	13689 ↔ 13709		Potential
	Disulfide bond	13845 ↔ 13865		Potential
	Disulfide bond	14001 ↔ 14021		Potential
	Disulfide bond	14157 ↔ 14177		Potential
	Disulfide bond	14313 ↔ 14333		Potential
	Disulfide bond	14469 ↔ 14489		Potential
	Disulfide bond	14627 ↔ 14647		Potential
	Disulfide bond	14783 ↔ 14803		Potential
	Disulfide bond	14939 ↔ 14959		Potential
	Disulfide bond	15095 ↔ 15115		Potential
	Disulfide bond	15251 ↔ 15271		Potential
	Disulfide bond	15407 ↔ 15427		Potential
	Disulfide bond	15563 ↔ 15583		Potential
	Disulfide bond	15719 ↔ 15739		Potential
	Disulfide bond	15874 ↔ 15894		Potential
	Disulfide bond	16185 ↔ 16205		Potential
	Disulfide bond	16341 ↔ 16361		Potential
	Disulfide bond	16497 ↔ 16517		Potential
	Disulfide bond	16653 ↔ 16673		Potential
	Disulfide bond	16809 ↔ 16829		Potential
	Disulfide bond	16965 ↔ 16985		Potential
	Disulfide bond	17121 ↔ 17141		Potential
	Disulfide bond	17277 ↔ 17297		Potential
	Disulfide bond	17433 ↔ 17453		Potential
	Disulfide bond	17589 ↔ 17609		Potential
	Disulfide bond	17745 ↔ 17765		Potential
	Disulfide bond	18057 ↔ 18077		Potential
	Disulfide bond	18369 ↔ 18389		Potential
	Disulfide bond	18681 ↔ 18701		Potential
	Disulfide bond	18993 ↔ 19013		Potential
	Disulfide bond	19305 ↔ 19325		Potential
	Disulfide bond	19617 ↔ 19637		Potential
	Disulfide bond	19928 ↔ 19948		Potential
	Disulfide bond	20396 ↔ 20416		Potential
	Disulfide bond	20552 ↔ 20572		Potential
	Disulfide bond	20708 ↔ 20728		Potential
	Disulfide bond	20864 ↔ 20884		Potential
	Disulfide bond	21020 ↔ 21040		Potential
	Disulfide bond	21176 ↔ 21196		Potential
	Disulfide bond	21332 ↔ 21352		Potential
	Disulfide bond	21621 ↔ 21641		Potential
	Disulfide bond	21771 ↔ 21791		Potential
	Disulfide bond	22018 ↔ 22038		Potential
Natural variations
	Natural variant	545	1	T → A. Corresponds to variant rs17000957 [ dbSNP | Ensembl ].		VAR_056592
	Natural variant	1015	1	R → G. Corresponds to variant rs17000950 [ dbSNP | Ensembl ].		VAR_056593
	Natural variant	1032	1	S → T. Corresponds to variant rs10411228 [ dbSNP | Ensembl ].		VAR_056594
	Natural variant	1041	1	P → S. Corresponds to variant rs10406202 [ dbSNP | Ensembl ].		VAR_056595
	Natural variant	1162	1	T → I. Corresponds to variant rs17000947 [ dbSNP | Ensembl ].		VAR_056596
	Natural variant	1266	1	K → N. Corresponds to variant rs1596797 [ dbSNP | Ensembl ].		VAR_056597
	Natural variant	1353	1	H → Y. Corresponds to variant rs12611293 [ dbSNP | Ensembl ].		VAR_056598
	Natural variant	1400	1	K → N. Corresponds to variant rs1596798 [ dbSNP | Ensembl ].		VAR_056599
	Natural variant	1833	1	L → F. Corresponds to variant rs4520945 [ dbSNP | Ensembl ].		VAR_056600
	Natural variant	1953	1	S → P. Corresponds to variant rs1108380 [ dbSNP | Ensembl ].		VAR_056601
	Natural variant	2058	1	S → P. Corresponds to variant rs1574479 [ dbSNP | Ensembl ].		VAR_056602
	Natural variant	2150	1	I → V. Corresponds to variant rs10407633 [ dbSNP | Ensembl ].		VAR_056603
	Natural variant	2271	1	T → A. Corresponds to variant rs11085805 [ dbSNP | Ensembl ].		VAR_056604
	Natural variant	2288	1	V → L. Corresponds to variant rs10410933 [ dbSNP | Ensembl ].		VAR_056605
	Natural variant	2356	1	D → E. Corresponds to variant rs10416013 [ dbSNP | Ensembl ].		VAR_056606
	Natural variant	2747	1	A → T. Corresponds to variant rs10402538 [ dbSNP | Ensembl ].		VAR_056607
	Natural variant	2786	1	M → I. Corresponds to variant rs17000886 [ dbSNP | Ensembl ].		VAR_056608
	Natural variant	2834	1	T → M. Corresponds to variant rs10407623 [ dbSNP | Ensembl ].		VAR_056609
	Natural variant	3574	1	R → H. Corresponds to variant rs2591594 [ dbSNP | Ensembl ].		VAR_056610
	Natural variant	5743	1	H → D. Corresponds to variant rs1559172 [ dbSNP | Ensembl ].		VAR_056611
	Natural variant	5756	1	A → T. Corresponds to variant rs1559171 [ dbSNP | Ensembl ].		VAR_056612
	Natural variant	5854	1	F → V. Corresponds to variant rs1862460 [ dbSNP | Ensembl ].		VAR_056613
	Natural variant	7065	1	T → A. Corresponds to variant rs17000770 [ dbSNP | Ensembl ].		VAR_056614
	Natural variant	7274	1	I → V. Corresponds to variant rs1867691 [ dbSNP | Ensembl ].		VAR_056615
	Natural variant	10509	1	T → N. Corresponds to variant rs11670461 [ dbSNP | Ensembl ].		VAR_056616
Experimental info
	Sequence conflict	8346	1	D → A in AAK74120. Ref.3
	Sequence conflict	8580	1	A → T in AAK74120. Ref.3
	Sequence conflict	9061	1	S → T in AAK74120. Ref.3
	Sequence conflict	9074	1	A → T in AAK74120. Ref.3
	Sequence conflict	9131	1	D → E in AAK74120. Ref.3
	Sequence conflict	9407	1	Q → R in AAK74120. Ref.3
	Sequence conflict	9504	1	T → A in AAK74120. Ref.3
	Sequence conflict	9610	1	S → P in AAK74120. Ref.3
	Sequence conflict	9852	1	D → E in AAK74120. Ref.3
	Sequence conflict	9901	1	Y → F in AAK74120. Ref.3
	Sequence conflict	10171	1	F → L in AAK74120. Ref.3
	Sequence conflict	10396	1	T → S in AAK74120. Ref.3
	Sequence conflict	10515	1	R → M in AAK74120. Ref.3
	Sequence conflict	10522	1	L → P in AAK74120. Ref.3
	Sequence conflict	10563	1	L → F in AAK74120. Ref.3
	Sequence conflict	10830	1	P → S in AAK74120. Ref.3
	Sequence conflict	11156	1	S → F in AAK74120. Ref.3
	Sequence conflict	11201	1	A → G in AAK74120. Ref.3
	Sequence conflict	11457	1	G → D in AAK74120. Ref.3
	Sequence conflict	11506	1	K → R in AAK74120. Ref.3
	Sequence conflict	11577	1	V → A in AAK74120. Ref.3
	Sequence conflict	11783	1	G → E in AAK74120. Ref.3
	Sequence conflict	12142	1	M → T in AAK74120. Ref.3
	Sequence conflict	12226	1	A → T in AAK74120. Ref.3
	Sequence conflict	12582	1	L → V in AAK74120. Ref.3
	Sequence conflict	12629	1	L → V in AAK74120. Ref.3
	Sequence conflict	12695	1	A → SAT in AAK74120. Ref.3
	Sequence conflict	12713	1	Q → K in AAK74120. Ref.3
	Sequence conflict	12720	1	H → C in AAK74120. Ref.3
	Sequence conflict	12735	1	G → S in AAK74120. Ref.3
	Sequence conflict	12744 – 12899	156	Missing in AAK74120. Ref.3
	Sequence conflict	13352	1	T → A in AAK74120. Ref.3
	Sequence conflict	13519 – 14924	1406	Missing in AAK74120. Ref.3
	Sequence conflict	15053	1	D → N in AAK74120. Ref.3
	Sequence conflict	15215 – 20515	5301	Missing in AAK74120. Ref.3
	Sequence conflict	20515	1	V → E in BAC87568. Ref.5
	Sequence conflict	20760 – 21071	312	Missing in BAC87568. Ref.5
	Sequence conflict	20839	1	T → I in AAK74120. Ref.3
	Sequence conflict	20842	1	R → S in AAK74120. Ref.3
	Sequence conflict	20977	1	T → I in AAK74120. Ref.3
	Sequence conflict	21384	1	H → P in AAK74120. Ref.3
	Sequence conflict	21384	1	H → P in BAC87568. Ref.5
	Sequence conflict	21487	1	S → C in AAK74120. Ref.3
	Sequence conflict	21487	1	S → C in BAC87568. Ref.5
	Sequence conflict	21602	1	K → Q in AAK74120. Ref.3
	Sequence conflict	21602	1	K → Q in BAC87568. Ref.5
	Sequence conflict	21686 – 21695	10	YNEPGLDEPP → HHTLQRQSTT in AAK74120. Ref.3
	Sequence conflict	21691	1	L → P in AAK74120. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8WXI7 [UniParc]. Last modified March 1, 2003. Version 2. Checksum: B3E7BDF19997A440	FASTA	22,152	2,353,428
	10 20 30 40 50 60 MLKPSGLPGS SSPTRSLMTG SRSTKATPEM DSGLTGATLS PKTSTGAIVV TEHTLPFTSP 70 80 90 100 110 120 DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT 130 140 150 160 170 180 SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW 190 200 210 220 230 240 DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL 250 260 270 280 290 300 SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI 310 320 330 340 350 360 FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT 370 380 390 400 410 420 AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT 430 440 450 460 470 480 HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT 490 500 510 520 530 540 RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS 550 560 570 580 590 600 PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT 610 620 630 640 650 660 HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA 670 680 690 700 710 720 GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI 730 740 750 760 770 780 STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT 790 800 810 820 830 840 SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL 850 860 870 880 890 900 PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT 910 920 930 940 950 960 MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA 970 980 990 1000 1010 1020 APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT 1030 1040 1050 1060 1070 1080 ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM 1090 1100 1110 1120 1130 1140 SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS 1150 1160 1170 1180 1190 1200 PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS 1210 1220 1230 1240 1250 1260 LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE 1270 1280 1290 1300 1310 1320 SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD 1330 1340 1350 1360 1370 1380 PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA 1390 1400 1410 1420 1430 1440 TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG 1450 1460 1470 1480 1490 1500 EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS 1510 1520 1530 1540 1550 1560 KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA 1570 1580 1590 1600 1610 1620 TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET 1630 1640 1650 1660 1670 1680 GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT 1690 1700 1710 1720 1730 1740 MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA 1750 1760 1770 1780 1790 1800 EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL 1810 1820 1830 1840 1850 1860 GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA 1870 1880 1890 1900 1910 1920 TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTDTE KSEVSSSIHP RPETSAPGAE 1930 1940 1950 1960 1970 1980 TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI 1990 2000 2010 2020 2030 2040 EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS 2050 2060 2070 2080 2090 2100 TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA 2110 2120 2130 2140 2150 2160 AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT 2170 2180 2190 2200 2210 2220 SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP 2230 2240 2250 2260 2270 2280 VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL 2290 2300 2310 2320 2330 2340 THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST 2350 2360 2370 2380 2390 2400 VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT 2410 2420 2430 2440 2450 2460 ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE 2470 2480 2490 2500 2510 2520 TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWASVGS TTDLPAMGFL 2530 2540 2550 2560 2570 2580 KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT 2590 2600 2610 2620 2630 2640 PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF 2650 2660 2670 2680 2690 2700 PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK 2710 2720 2730 2740 2750 2760 TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV 2770 2780 2790 2800 2810 2820 FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT 2830 2840 2850 2860 2870 2880 MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP 2890 2900 2910 2920 2930 2940 PSTWGIPQST LTFEFSEVPS LDTKSASLPT PGQSLNTIPD SDASTASSSL SKSPEKNPRA 2950 2960 2970 2980 2990 3000 RMMTSTKAIS ASSFQSTGFT ETPEGSASPS MAGHEPRVPT SGTGDPRYAS ESMSYPDPSK 3010 3020 3030 3040 3050 3060 ASSAMTSTSL ASKLTTLFST GQAARSGSSS SPISLSTEKE TSFLSPTAST SRKTSLFLGP 3070 3080 3090 3100 3110 3120 SMARQPNILV HLQTSALTLS PTSTLNMSQE EPPELTSSQT IAEEEGTTAE TQTLTFTPSE 3130 3140 3150 3160 3170 3180 TPTSLLPVSS PTEPTARRKS SPETWASSIS VPAKTSLVET TDGTLVTTIK MSSQAAQGNS 3190 3200 3210 3220 3230 3240 TWPAPAEETG TSPAGTSPGS PEVSTTLKIM SSKEPSISPE IRSTVRNSPW KTPETTVPME 3250 3260 3270 3280 3290 3300 TTVEPVTLQS TALGSGSTSI SHLPTGTTSP TKSPTENMLA TERVSLSPSP PEAWTNLYSG 3310 3320 3330 3340 3350 3360 TPGGTRQSLA TMSSVSLESP TARSITGTGQ QSSPELVSKT TGMEFSMWHG STGGTTGDTH 3370 3380 3390 3400 3410 3420 VSLSTSSNIL EDPVTSPNSV SSLTDKSKHK TETWVSTTAI PSTVLNNKIM AAEQQTSRSV 3430 3440 3450 3460 3470 3480 DEAYSSTSSW SDQTSGSDIT LGASPDVTNT LYITSTAQTT SLVSLPSGDQ GITSLTNPSG 3490 3500 3510 3520 3530 3540 GKTSSASSVT SPSIGLETLR ANVSAVKSDI APTAGHLSQT SSPAEVSILD VTTAPTPGIS 3550 3560 3570 3580 3590 3600 TTITTMGTNS ISTTTPNPEV GMSTMDSTPA TERRTTSTEH PSTWSSTAAS DSWTVTDMTS 3610 3620 3630 3640 3650 3660 NLKVARSPGT ISTMHTTSFL ASSTELDSMS TPHGRITVIG TSLVTPSSDA SAVKTETSTS 3670 3680 3690 3700 3710 3720 ERTLSPSDTT ASTPISTFSR VQRMSISVPD ILSTSWTPSS TEAEDVPVSM VSTDHASTKT 3730 3740 3750 3760 3770 3780 DPNTPLSTFL FDSLSTLDWD TGRSLSSATA TTSAPQGATT PQELTLETMI SPATSQLPFS 3790 3800 3810 3820 3830 3840 IGHITSAVTP AAMARSSGVT FSRPDPTSKK AEQTSTQLPT TTSAHPGQVP RSAATTLDVI 3850 3860 3870 3880 3890 3900 PHTAKTPDAT FQRQGQTALT TEARATSDSW NEKEKSTPSA PWITEMMNSV SEDTIKEVTS 3910 3920 3930 3940 3950 3960 SSSVLKDPEY AGHKLGIWDD FIPKFGKAAH MRELPLLSPP QDKEAIHPST NTVETTGWVT 3970 3980 3990 4000 4010 4020 SSEHASHSTI PAHSASSKLT SPVVTTSTRE QAIVSMSTTT WPESTRARTE PNSFLTIELR 4030 4040 4050 4060 4070 4080 DVSPYMDTSS TTQTSIISSP GSTAITKGPR TEITSSKRIS SSFLAQSMRS SDSPSEAITR 4090 4100 4110 4120 4130 4140 LSNFPAMTES GGMILAMQTS PPGATSLSAP TLDTSATASW TGTPLATTQR FTYSEKTTLF 4150 4160 4170 4180 4190 4200 SKGPEDTSQP SPPSVEETSS SSSLVPIHAT TSPSNILLTS QGHSPSSTPP VTSVFLSETS 4210 4220 4230 4240 4250 4260 GLGKTTDMSR ISLEPGTSLP PNLSSTAGEA LSTYEASRDT KAIHHSADTA VTNMEATSSE 4270 4280 4290 4300 4310 4320 YSPIPGHTKP SKATSPLVTS HIMGDITSST SVFGSSETTE IETVSSVNQG LQERSTSQVA 4330 4340 4350 4360 4370 4380 SSATETSTVI THVSSGDATT HVTKTQATFS SGTSISSPHQ FITSTNTFTD VSTNPSTSLI 4390 4400 4410 4420 4430 4440 MTESSGVTIT TQTGPTGAAT QGPYLLDTST MPYLTETPLA VTPDFMQSEK TTLISKGPKD 4450 4460 4470 4480 4490 4500 VTWTSPPSVA ETSYPSSLTP FLVTTIPPAT STLQGQHTSS PVSATSVLTS GLVKTTDMLN 4510 4520 4530 4540 4550 4560 TSMEPVTNSP QNLNNPSNEI LATLAATTDI ETIHPSINKA VTNMGTASSA HVLHSTLPVS 4570 4580 4590 4600 4610 4620 SEPSTATSPM VPASSMGDAL ASISIPGSET TDIEGEPTSS LTAGRKENST LQEMNSTTES 4630 4640 4650 4660 4670 4680 NIILSNVSVG AITEATKMEV PSFDATFIPT PAQSTKFPDI FSVASSRLSN SPPMTISTHM 4690 4700 4710 4720 4730 4740 TTTQTGSSGA TSKIPLALDT STLETSAGTP SVVTEGFAHS KITTAMNNDV KDVSQTNPPF 4750 4760 4770 4780 4790 4800 QDEASSPSSQ APVLVTTLPS SVAFTPQWHS TSSPVSMSSV LTSSLVKTAG KVDTSLETVT 4810 4820 4830 4840 4850 4860 SSPQSMSNTL DDISVTSAAT TDIETTHPSI NTVVTNVGTT GSAFESHSTV SAYPEPSKVT 4870 4880 4890 4900 4910 4920 SPNVTTSTME DTTISRSIPK SSKTTRTETE TTSSLTPKLR ETSISQEITS STETSTVPYK 4930 4940 4950 4960 4970 4980 ELTGATTEVS RTDVTSSSST SFPGPDQSTV SLDISTETNT RLSTSPIMTE SAEITITTQT 4990 5000 5010 5020 5030 5040 GPHGATSQDT FTMDPSNTTP QAGIHSAMTH GFSQLDVTTL MSRIPQDVSW TSPPSVDKTS 5050 5060 5070 5080 5090 5100 SPSSFLSSPA MTTPSLISST LPEDKLSSPM TSLLTSGLVK ITDILRTRLE PVTSSLPNFS 5110 5120 5130 5140 5150 5160 STSDKILATS KDSKDTKEIF PSINTEETNV KANNSGHESH SPALADSETP KATTQMVITT 5170 5180 5190 5200 5210 5220 TVGDPAPSTS MPVHGSSETT NIKREPTYFL TPRLRETSTS QESSFPTDTS FLLSKVPTGT 5230 5240 5250 5260 5270 5280 ITEVSSTGVN SSSKISTPDH DKSTVPPDTF TGEIPRVFTS SIKTKSAEMT ITTQASPPES 5290 5300 5310 5320 5330 5340 ASHSTLPLDT STTLSQGGTH STVTQGFPYS EVTTLMGMGP GNVSWMTTPP VEETSSVSSL 5350 5360 5370 5380 5390 5400 MSSPAMTSPS PVSSTSPQSI PSSPLPVTAL PTSVLVTTTD VLGTTSPESV TSSPPNLSSI 5410 5420 5430 5440 5450 5460 THERPATYKD TAHTEAAMHH STNTAVTNVG TSGSGHKSQS SVLADSETSK ATPLMSTTST 5470 5480 5490 5500 5510 5520 LGDTSVSTST PNISQTNQIQ TEPTASLSPR LRESSTSEKT SSTTETNTAF SYVPTGAITQ 5530 5540 5550 5560 5570 5580 ASRTEISSSR TSISDLDRPT IAPDISTGMI TRLFTSPIMT KSAEMTVTTQ TTTPGATSQG 5590 5600 5610 5620 5630 5640 ILPWDTSTTL FQGGTHSTVS QGFPHSEITT LRSRTPGDVS WMTTPPVEET SSGFSLMSPS 5650 5660 5670 5680 5690 5700 MTSPSPVSST SPESIPSSPL PVTALLTSVL VTTTNVLGTT SPETVTSSPP NLSSPTQERL 5710 5720 5730 5740 5750 5760 TTYKDTAHTE AMHASMHTNT AVANVGTSIS GHESQSSVPA DSHTSKATSP MGITFAMGDT 5770 5780 5790 5800 5810 5820 SVSTSTPAFF ETRIQTESTS SLIPGLRDTR TSEEINTVTE TSTVLSEVPT TTTTEVSRTE 5830 5840 5850 5860 5870 5880 VITSSRTTIS GPDHSKMSPY ISTETITRLS TFPFVTGSTE MAITNQTGPI GTISQATLTL 5890 5900 5910 5920 5930 5940 DTSSTASWEG THSPVTQRFP HSEETTTMSR STKGVSWQSP PSVEETSSPS SPVPLPAITS 5950 5960 5970 5980 5990 6000 HSSLYSAVSG SSPTSALPVT SLLTSGRRKT IDMLDTHSEL VTSSLPSASS FSGEILTSEA 6010 6020 6030 6040 6050 6060 STNTETIHFS ENTAETNMGT TNSMHKLHSS VSIHSQPSGH TPPKVTGSMM EDAIVSTSTP 6070 6080 6090 6100 6110 6120 GSPETKNVDR DSTSPLTPEL KEDSTALVMN STTESNTVFS SVSLDAATEV SRAEVTYYDP 6130 6140 6150 6160 6170 6180 TFMPASAQST KSPDISPEAS SSHSNSPPLT ISTHKTIATQ TGPSGVTSLG QLTLDTSTIA 6190 6200 6210 6220 6230 6240 TSAGTPSART QDFVDSETTS VMNNDLNDVL KTSPFSAEEA NSLSSQAPLL VTTSPSPVTS 6250 6260 6270 6280 6290 6300 TLQEHSTSSL VSVTSVPTPT LAKITDMDTN LEPVTRSPQN LRNTLATSEA TTDTHTMHPS 6310 6320 6330 6340 6350 6360 INTAMANVGT TSSPNEFYFT VSPDSDPYKA TSAVVITSTS GDSIVSTSMP RSSAMKKIES 6370 6380 6390 6400 6410 6420 ETTFSLIFRL RETSTSQKIG SSSDTSTVFD KAFTAATTEV SRTELTSSSR TSIQGTEKPT 6430 6440 6450 6460 6470 6480 MSPDTSTRSV TMLSTFAGLT KSEERTIATQ TGPHRATSQG TLTWDTSITT SQAGTHSAMT 6490 6500 6510 6520 6530 6540 HGFSQLDLST LTSRVPEYIS GTSPPSVEKT SSSSSLLSLP AITSPSPVPT TLPESRPSSP 6550 6560 6570 6580 6590 6600 VHLTSLPTSG LVKTTDMLAS VASLPPNLGS TSHKIPTTSE DIKDTEKMYP STNIAVTNVG 6610 6620 6630 6640 6650 6660 TTTSEKESYS SVPAYSEPPK VTSPMVTSFN IRDTIVSTSM PGSSEITRIE MESTFSVAHG 6670 6680 6690 6700 6710 6720 LKGTSTSQDP IVSTEKSAVL HKLTTGATET SRTEVASSRR TSIPGPDHST ESPDISTEVI 6730 6740 6750 6760 6770 6780 PSLPISLGIT ESSNMTIITR TGPPLGSTSQ GTFTLDTPTT SSRAGTHSMA TQEFPHSEMT 6790 6800 6810 6820 6830 6840 TVMNKDPEIL SWTIPPSIEK TSFSSSLMPS PAMTSPPVSS TLPKTIHTTP SPMTSLLTPS 6850 6860 6870 6880 6890 6900 LVMTTDTLGT SPEPTTSSPP NLSSTSHVIL TTDEDTTAIE AMHPSTSTAA TNVETTCSGH 6910 6920 6930 6940 6950 6960 GSQSSVLTDS EKTKATAPMD TTSTMGHTTV STSMSVSSET TKIKRESTYS LTPGLRETSI 6970 6980 6990 7000 7010 7020 SQNASFSTDT SIVLSEVPTG TTAEVSRTEV TSSGRTSIPG PSQSTVLPEI STRTMTRLFA 7030 7040 7050 7060 7070 7080 SPTMTESAEM TIPTQTGPSG STSQDTLTLD TSTTKSQAKT HSTLTQRFPH SEMTTLMSRG 7090 7100 7110 7120 7130 7140 PGDMSWQSSP SLENPSSLPS LLSLPATTSP PPISSTLPVT ISSSPLPVTS LLTSSPVTTT 7150 7160 7170 7180 7190 7200 DMLHTSPELV TSSPPKLSHT SDERLTTGKD TTNTEAVHPS TNTAASNVEI PSFGHESPSS 7210 7220 7230 7240 7250 7260 ALADSETSKA TSPMFITSTQ EDTTVAISTP HFLETSRIQK ESISSLSPKL RETGSSVETS 7270 7280 7290 7300 7310 7320 SAIETSAVLS EVSIGATTEI SRTEVTSSSR TSISGSAEST MLPEISTTRK IIKFPTSPIL 7330 7340 7350 7360 7370 7380 AESSEMTIKT QTSPPGSTSE STFTLDTSTT PSLVITHSTM TQRLPHSEIT TLVSRGAGDV 7390 7400 7410 7420 7430 7440 PRPSSLPVEE TSPPSSQLSL SAMISPSPVS STLPASSHSS SASVTSPLTP GQVKTTEVLD 7450 7460 7470 7480 7490 7500 ASAEPETSSP PSLSSTSVEI LATSEVTTDT EKIHPFPNTA VTKVGTSSSG HESPSSVLPD 7510 7520 7530 7540 7550 7560 SETTKATSAM GTISIMGDTS VSTLTPALSN TRKIQSEPAS SLTTRLRETS TSEETSLATE 7570 7580 7590 7600 7610 7620 ANTVLSKVST GATTEVSRTE AISFSRTSMS GPEQSTMSQD ISIGTIPRIS ASSVLTESAK 7630 7640 7650 7660 7670 7680 MTITTQTGPS ESTLESTLNL NTATTPSWVE THSIVIQGFP HPEMTTSMGR GPGGVSWPSP 7690 7700 7710 7720 7730 7740 PFVKETSPPS SPLSLPAVTS PHPVSTTFLA HIPPSPLPVT SLLTSGPATT TDILGTSTEP 7750 7760 7770 7780 7790 7800 GTSSSSSLST TSHERLTTYK DTAHTEAVHP STNTGGTNVA TTSSGYKSQS SVLADSSPMC 7810 7820 7830 7840 7850 7860 TTSTMGDTSV LTSTPAFLET RRIQTELASS LTPGLRESSG SEGTSSGTKM STVLSKVPTG 7870 7880 7890 7900 7910 7920 ATTEISKEDV TSIPGPAQST ISPDISTRTV SWFSTSPVMT ESAEITMNTH TSPLGATTQG 7930 7940 7950 7960 7970 7980 TSTLATSSTT SLTMTHSTIS QGFSHSQMST LMRRGPEDVS WMSPPLLEKT RPSFSLMSSP 7990 8000 8010 8020 8030 8040 ATTSPSPVSS TLPESISSSP LPVTSLLTSG LAKTTDMLHK SSEPVTNSPA NLSSTSVEIL 8050 8060 8070 8080 8090 8100 ATSEVTTDTE KTHPSSNRTV TDVGTSSSGH ESTSFVLADS QTSKVTSPMV ITSTMEDTSV 8110 8120 8130 8140 8150 8160 STSTPGFFET SRIQTEPTSS LTLGLRKTSS SEGTSLATEM STVLSGVPTG ATAEVSRTEV 8170 8180 8190 8200 8210 8220 TSSSRTSISG FAQLTVSPET STETITRLPT SSIMTESAEM MIKTQTDPPG STPESTHTVD 8230 8240 8250 8260 8270 8280 ISTTPNWVET HSTVTQRFSH SEMTTLVSRS PGDMLWPSQS SVEETSSASS LLSLPATTSP 8290 8300 8310 8320 8330 8340 SPVSSTLVED FPSASLPVTS LLTPGLVITT DRMGISREPG TSSTSNLSST SHERLTTLED 8350 8360 8370 8380 8390 8400 TVDTEDMQPS THTAVTNVRT SISGHESQSS VLSDSETPKA TSPMGTTYTM GETSVSISTS 8410 8420 8430 8440 8450 8460 DFFETSRIQI EPTSSLTSGL RETSSSERIS SATEGSTVLS EVPSGATTEV SRTEVISSRG 8470 8480 8490 8500 8510 8520 TSMSGPDQFT ISPDISTEAI TRLSTSPIMT ESAESAITIE TGSPGATSEG TLTLDTSTTT 8530 8540 8550 8560 8570 8580 FWSGTHSTAS PGFSHSEMTT LMSRTPGDVP WPSLPSVEEA SSVSSSLSSP AMTSTSFFSA 8590 8600 8610 8620 8630 8640 LPESISSSPH PVTALLTLGP VKTTDMLRTS SEPETSSPPN LSSTSAEILA TSEVTKDREK 8650 8660 8670 8680 8690 8700 IHPSSNTPVV NVGTVIYKHL SPSSVLADLV TTKPTSPMAT TSTLGNTSVS TSTPAFPETM 8710 8720 8730 8740 8750 8760 MTQPTSSLTS GLREISTSQE TSSATERSAS LSGMPTGATT KVSRTEALSL GRTSTPGPAQ 8770 8780 8790 8800 8810 8820 STISPEISTE TITRISTPLT TTGSAEMTIT PKTGHSGASS QGTFTLDTSS RASWPGTHSA 8830 8840 8850 8860 8870 8880 ATHRSPHSGM TTPMSRGPED VSWPSRPSVE KTSPPSSLVS LSAVTSPSPL YSTPSESSHS 8890 8900 8910 8920 8930 8940 SPLRVTSLFT PVMMKTTDML DTSLEPVTTS PPSMNITSDE SLATSKATME TEAIQLSENT 8950 8960 8970 8980 8990 9000 AVTQMGTISA RQEFYSSYPG LPEPSKVTSP VVTSSTIKDI VSTTIPASSE ITRIEMESTS 9010 9020 9030 9040 9050 9060 TLTPTPRETS TSQEIHSATK PSTVPYKALT SATIEDSMTQ VMSSSRGPSP DQSTMSQDIS 9070 9080 9090 9100 9110 9120 SEVITRLSTS PIKAESTEMT ITTQTGSPGA TSRGTLTLDT STTFMSGTHS TASQGFSHSQ 9130 9140 9150 9160 9170 9180 MTALMSRTPG DVPWLSHPSV EEASSASFSL SSPVMTSSSP VSSTLPDSIH SSSLPVTSLL 9190 9200 9210 9220 9230 9240 TSGLVKTTEL LGTSSEPETS SPPNLSSTSA EILATTEVTT DTEKLEMTNV VTSGYTHESP 9250 9260 9270 9280 9290 9300 SSVLADSVTT KATSSMGITY PTGDTNVLTS TPAFSDTSRI QTKSKLSLTP GLMETSISEE 9310 9320 9330 9340 9350 9360 TSSATEKSTV LSSVPTGATT EVSRTEAISS SRTSIPGPAQ STMSSDTSME TITRISTPLT 9370 9380 9390 9400 9410 9420 RKESTDMAIT PKTGPSGATS QGTFTLDSSS TASWPGTHSA TTQRFPQSVV TTPMSRGPED 9430 9440 9450 9460 9470 9480 VSWPSPLSVE KNSPPSSLVS SSSVTSPSPL YSTPSGSSHS SPVPVTSLFT SIMMKATDML 9490 9500 9510 9520 9530 9540 DASLEPETTS APNMNITSDE SLATSKATTE TEAIHVFENT AASHVETTSA TEELYSSSPG 9550 9560 9570 9580 9590 9600 FSEPTKVISP VVTSSSIRDN MVSTTMPGSS GITRIEIESM SSLTPGLRET RTSQDITSST 9610 9620 9630 9640 9650 9660 ETSTVLYKMS SGATPEVSRT EVMPSSRTSI PGPAQSTMSL DISDEVVTRL STSPIMTESA 9670 9680 9690 9700 9710 9720 EITITTQTGY SLATSQVTLP LGTSMTFLSG THSTMSQGLS HSEMTNLMSR GPESLSWTSP 9730 9740 9750 9760 9770 9780 RFVETTRSSS SLTSLPLTTS LSPVSSTLLD SSPSSPLPVT SLILPGLVKT TEVLDTSSEP 9790 9800 9810 9820 9830 9840 KTSSSPNLSS TSVEIPATSE IMTDTEKIHP SSNTAVAKVR TSSSVHESHS SVLADSETTI 9850 9860 9870 9880 9890 9900 TIPSMGITSA VDDTTVFTSN PAFSETRRIP TEPTFSLTPG FRETSTSEET TSITETSAVL 9910 9920 9930 9940 9950 9960 YGVPTSATTE VSMTEIMSSN RTHIPDSDQS TMSPDIITEV ITRLSSSSMM SESTQMTITT 9970 9980 9990 10000 10010 10020 QKSSPGATAQ STLTLATTTA PLARTHSTVP PRFLHSEMTT LMSRSPENPS WKSSPFVEKT 10030 10040 10050 10060 10070 10080 SSSSSLLSLP VTTSPSVSST LPQSIPSSSF SVTSLLTPGM VKTTDTSTEP GTSLSPNLSG 10090 10100 10110 10120 10130 10140 TSVEILAASE VTTDTEKIHP SSSMAVTNVG TTSSGHELYS SVSIHSEPSK ATYPVGTPSS 10150 10160 10170 10180 10190 10200 MAETSISTSM PANFETTGFE AEPFSHLTSG FRKTNMSLDT SSVTPTNTPS SPGSTHLLQS 10210 10220 10230 10240 10250 10260 SKTDFTSSAK TSSPDWPPAS QYTEIPVDII TPFNASPSIT ESTGITSFPE SRFTMSVTES 10270 10280 10290 10300 10310 10320 THHLSTDLLP SAETISTGTV MPSLSEAMTS FATTGVPRAI SGSGSPFSRT ESGPGDATLS 10330 10340 10350 10360 10370 10380 TIAESLPSST PVPFSSSTFT TTDSSTIPAL HEITSSSATP YRVDTSLGTE SSTTEGRLVM 10390 10400 10410 10420 10430 10440 VSTLDTSSQP GRTSSTPILD TRMTESVELG TVTSAYQVPS LSTRLTRTDG IMEHITKIPN 10450 10460 10470 10480 10490 10500 EAAHRGTIRP VKGPQTSTSP ASPKGLHTGG TKRMETTTTA LKTTTTALKT TSRATLTTSV 10510 10520 10530 10540 10550 10560 YTPTLGTLTP LNASRQMAST ILTEMMITTP YVFPDVPETT SSLATSLGAE TSTALPRTTP 10570 10580 10590 10600 10610 10620 SVLNRESETT ASLVSRSGAE RSPVIQTLDV SSSEPDTTAS WVIHPAETIP TVSKTTPNFF 10630 10640 10650 10660 10670 10680 HSELDTVSST ATSHGADVSS AIPTNISPSE LDALTPLVTI SGTDTSTTFP TLTKSPHETE 10690 10700 10710 10720 10730 10740 TRTTWLTHPA ETSSTIPRTI PNFSHHESDA TPSIATSPGA ETSSAIPIMT VSPGAEDLVT 10750 10760 10770 10780 10790 10800 SQVTSSGTDR NMTIPTLTLS PGEPKTIASL VTHPEAQTSS AIPTSTISPA VSRLVTSMVT 10810 10820 10830 10840 10850 10860 SLAAKTSTTN RALTNSPGEP ATTVSLVTHP AQTSPTVPWT TSIFFHSKSD TTPSMTTSHG 10870 10880 10890 10900 10910 10920 AESSSAVPTP TVSTEVPGVV TPLVTSSRAV ISTTIPILTL SPGEPETTPS MATSHGEEAS 10930 10940 10950 10960 10970 10980 SAIPTPTVSP GVPGVVTSLV TSSRAVTSTT IPILTFSLGE PETTPSMATS HGTEAGSAVP 10990 11000 11010 11020 11030 11040 TVLPEVPGMV TSLVASSRAV TSTTLPTLTL SPGEPETTPS MATSHGAEAS STVPTVSPEV 11050 11060 11070 11080 11090 11100 PGVVTSLVTS SSGVNSTSIP TLILSPGELE TTPSMATSHG AEASSAVPTP TVSPGVSGVV 11110 11120 11130 11140 11150 11160 TPLVTSSRAV TSTTIPILTL SSSEPETTPS MATSHGVEAS SAVLTVSPEV PGMVTSLVTS 11170 11180 11190 11200 11210 11220 SRAVTSTTIP TLTISSDEPE TTTSLVTHSE AKMISAIPTL AVSPTVQGLV TSLVTSSGSE 11230 11240 11250 11260 11270 11280 TSAFSNLTVA SSQPETIDSW VAHPGTEASS VVPTLTVSTG EPFTNISLVT HPAESSSTLP 11290 11300 11310 11320 11330 11340 RTTSRFSHSE LDTMPSTVTS PEAESSSAIS TTISPGIPGV LTSLVTSSGR DISATFPTVP 11350 11360 11370 11380 11390 11400 ESPHESEATA SWVTHPAVTS TTVPRTTPNY SHSEPDTTPS IATSPGAEAT SDFPTITVSP 11410 11420 11430 11440 11450 11460 DVPDMVTSQV TSSGTDTSIT IPTLTLSSGE PETTTSFITY SETHTSSAIP TLPVSPGASK 11470 11480 11490 11500 11510 11520 MLTSLVISSG TDSTTTFPTL TETPYEPETT AIQLIHPAET NTMVPKTTPK FSHSKSDTTL 11530 11540 11550 11560 11570 11580 PVAITSPGPE ASSAVSTTTI SPDMSDLVTS LVPSSGTDTS TTFPTLSETP YEPETTVTWL 11590 11600 11610 11620 11630 11640 THPAETSTTV SGTIPNFSHR GSDTAPSMVT SPGVDTRSGV PTTTIPPSIP GVVTSQVTSS 11650 11660 11670 11680 11690 11700 ATDTSTAIPT LTPSPGEPET TASSATHPGT QTGFTVPIRT VPSSEPDTMA SWVTHPPQTS 11710 11720 11730 11740 11750 11760 TPVSRTTSSF SHSSPDATPV MATSPRTEAS SAVLTTISPG APEMVTSQIT SSGAATSTTV 11770 11780 11790 11800 11810 11820 PTLTHSPGMP ETTALLSTHP RTGTSKTFPA STVFPQVSET TASLTIRPGA ETSTALPTQT 11830 11840 11850 11860 11870 11880 TSSLFTLLVT GTSRVDLSPT ASPGVSAKTA PLSTHPGTET STMIPTSTLS LGLLETTGLL 11890 11900 11910 11920 11930 11940 ATSSSAETST STLTLTVSPA VSGLSSASIT TDKPQTVTSW NTETSPSVTS VGPPEFSRTV 11950 11960 11970 11980 11990 12000 TGTTMTLIPS EMPTPPKTSH GEGVSPTTIL RTTMVEATNL ATTGSSPTVA KTTTTFNTLA 12010 12020 12030 12040 12050 12060 GSLFTPLTTP GMSTLASESV TSRTSYNHRS WISTTSSYNR RYWTPATSTP VTSTFSPGIS 12070 12080 12090 12100 12110 12120 TSSIPSSTAA TVPFMVPFTL NFTITNLQYE EDMRHPGSRK FNATERELQG LLKPLFRNSS 12130 12140 12150 12160 12170 12180 LEYLYSGCRL ASLRPEKDSS AMAVDAICTH RPDPEDLGLD RERLYWELSN LTNGIQELGP 12190 12200 12210 12220 12230 12240 YTLDRNSLYV NGFTHRSSMP TTSTPGTSTV DVGTSGTPSS SPSPTAAGPL LMPFTLNFTI 12250 12260 12270 12280 12290 12300 TNLQYEEDMR RTGSRKFNTM ESVLQGLLKP LFKNTSVGPL YSGCRLTLLR PEKDGAATGV 12310 12320 12330 12340 12350 12360 DAICTHRLDP KSPGLNREQL YWELSKLTND IEELGPYTLD RNSLYVNGFT HQSSVSTTST 12370 12380 12390 12400 12410 12420 PGTSTVDLRT SGTPSSLSSP TIMAAGPLLV PFTLNFTITN LQYGEDMGHP GSRKFNTTER 12430 12440 12450 12460 12470 12480 VLQGLLGPIF KNTSVGPLYS GCRLTSLRSE KDGAATGVDA ICIHHLDPKS PGLNRERLYW 12490 12500 12510 12520 12530 12540 ELSQLTNGIK ELGPYTLDRN SLYVNGFTHR TSVPTTSTPG TSTVDLGTSG TPFSLPSPAT 12550 12560 12570 12580 12590 12600 AGPLLVLFTL NFTITNLKYE EDMHRPGSRK FNTTERVLQT LLGPMFKNTS VGLLYSGCRL 12610 12620 12630 12640 12650 12660 TLLRSEKDGA ATGVDAICTH RLDPKSPGLD REQLYWELSQ LTNGIKELGP YTLDRNSLYV 12670 12680 12690 12700 12710 12720 NGFTHWIPVP TSSTPGTSTV DLGSGTPSSL PSPTAAGPLL VPFTLNFTIT NLQYEEDMHH 12730 12740 12750 12760 12770 12780 PGSRKFNTTE RVLQGLLGPM FKNTSVGLLY SGCRLTLLRS EKDGAATGVD AICTHRLDPK 12790 12800 12810 12820 12830 12840 SPGVDREQLY WELSQLTNGI KELGPYTLDR NSLYVNGFTH QTSAPNTSTP GTSTVDLGTS 12850 12860 12870 12880 12890 12900 GTPSSLPSPT SAGPLLVPFT LNFTITNLQY EEDMRHPGSR KFNTTERVLQ GLLKPLFKST 12910 12920 12930 12940 12950 12960 SVGPLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGV DREQLYWELS QLTNGIKELG 12970 12980 12990 13000 13010 13020 PYTLDRNSLY VNGFTHQTSA PNTSTPGTST VDLGTSGTPS SLPSPTSAGP LLVPFTLNFT 13030 13040 13050 13060 13070 13080 ITNLQYEEDM HHPGSRKFNT TERVLQGLLG PMFKNTSVGL LYSGCRLTLL RPEKNGAATG 13090 13100 13110 13120 13130 13140 MDAICSHRLD PKSPGLNREQ LYWELSQLTH GIKELGPYTL DRNSLYVNGF THRSSVAPTS 13150 13160 13170 13180 13190 13200 TPGTSTVDLG TSGTPSSLPS PTTAVPLLVP FTLNFTITNL QYGEDMRHPG SRKFNTTERV 13210 13220 13230 13240 13250 13260 LQGLLGPLFK NSSVGPLYSG CRLISLRSEK DGAATGVDAI CTHHLNPQSP GLDREQLYWQ 13270 13280 13290 13300 13310 13320 LSQMTNGIKE LGPYTLDRNS LYVNGFTHRS SGLTTSTPWT STVDLGTSGT PSPVPSPTTA 13330 13340 13350 13360 13370 13380 GPLLVPFTLN FTITNLQYEE DMHRPGSRKF NTTERVLQGL LSPIFKNSSV GPLYSGCRLT 13390 13400 13410 13420 13430 13440 SLRPEKDGAA TGMDAVCLYH PNPKRPGLDR EQLYWELSQL THNITELGPY SLDRDSLYVN 13450 13460 13470 13480 13490 13500 GFTHQNSVPT TSTPGTSTVY WATTGTPSSF PGHTEPGPLL IPFTFNFTIT NLHYEENMQH 13510 13520 13530 13540 13550 13560 PGSRKFNTTE RVLQGLLKPL FKNTSVGPLY SGCRLTSLRP EKDGAATGMD AVCLYHPNPK 13570 13580 13590 13600 13610 13620 RPGLDREQLY WELSQLTHNI TELGPYSLDR DSLYVNGFTH QNSVPTTSTP GTSTVYWATT 13630 13640 13650 13660 13670 13680 GTPSSFPGHT EPGPLLIPFT FNFTITNLHY EENMQHPGSR KFNTTERVLQ GLLKPLFKNT 13690 13700 13710 13720 13730 13740 SVGPLYSGCR LTLLRPEKHE AATGVDTICT HRVDPIGPGL DRERLYWELS QLTNSITELG 13750 13760 13770 13780 13790 13800 PYTLDRDSLY VNGFNPRSSV PTTSTPGTST VHLATSGTPS SLPGHTAPVP LLIPFTLNFT 13810 13820 13830 13840 13850 13860 ITNLHYEENM QHPGSRKFNT TERVLQGLLK PLFKNTSVGP LYSGCRLTLL RPEKHEAATG 13870 13880 13890 13900 13910 13920 VDTICTHRVD PIGPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THXXSXPTTS 13930 13940 13950 13960 13970 13980 TPGTSTVXXG TSGTPSSXPX XTSAGPLLVP FTLNFTITNL QYEEDMHHPG SRKFNTTERV 13990 14000 14010 14020 14030 14040 LQGLLGPMFK NTSVGLLYSG CRLTLLRPEK NGAATGMDAI CSHRLDPKSP GLDREQLYWE 14050 14060 14070 14080 14090 14100 LSQLTHGIKE LGPYTLDRNS LYVNGFTHRS SVAPTSTPGT STVDLGTSGT PSSLPSPTTA 14110 14120 14130 14140 14150 14160 VPLLVPFTLN FTITNLQYGE DMRHPGSRKF NTTERVLQGL LGPLFKNSSV GPLYSGCRLI 14170 14180 14190 14200 14210 14220 SLRSEKDGAA TGVDAICTHH LNPQSPGLDR EQLYWQLSQM TNGIKELGPY TLDRNSLYVN 14230 14240 14250 14260 14270 14280 GFTHRSSGLT TSTPWTSTVD LGTSGTPSPV PSPTTAGPLL VPFTLNFTIT NLQYEEDMHR 14290 14300 14310 14320 14330 14340 PGSRKFNATE RVLQGLLSPI FKNSSVGPLY SGCRLTSLRP EKDGAATGMD AVCLYHPNPK 14350 14360 14370 14380 14390 14400 RPGLDREQLY WELSQLTHNI TELGPYSLDR DSLYVNGFTH QSSMTTTRTP DTSTMHLATS 14410 14420 14430 14440 14450 14460 RTPASLSGPT TASPLLVLFT INCTITNLQY EEDMRRTGSR KFNTMESVLQ GLLKPLFKNT 14470 14480 14490 14500 14510 14520 SVGPLYSGCR LTLLRPKKDG AATGVDAICT HRLDPKSPGL NREQLYWELS KLTNDIEELG 14530 14540 14550 14560 14570 14580 PYTLDRNSLY VNGFTHQSSV STTSTPGTST VDLRTSGTPS SLSSPTIMXX XPLLXPFTXN 14590 14600 14610 14620 14630 14640 XTITNLXXXX XMXXPGSRKF NTTERVLQGL LRPLFKNTSV SSLYSGCRLT LLRPEKDGAA 14650 14660 14670 14680 14690 14700 TRVDAACTYR PDPKSPGLDR EQLYWELSQL THSITELGPY TLDRVSLYVN GFNPRSSVPT 14710 14720 14730 14740 14750 14760 TSTPGTSTVH LATSGTPSSL PGHTXXXPLL XPFTXNXTIT NLXXXXXMXX PGSRKFNTTE 14770 14780 14790 14800 14810 14820 RVLQGLLKPL FRNSSLEYLY SGCRLASLRP EKDSSAMAVD AICTHRPDPE DLGLDRERLY 14830 14840 14850 14860 14870 14880 WELSNLTNGI QELGPYTLDR NSLYVNGFTH RSSGLTTSTP WTSTVDLGTS GTPSPVPSPT 14890 14900 14910 14920 14930 14940 TAGPLLVPFT LNFTITNLQY EEDMHRPGSR RFNTTERVLQ GLLTPLFKNT SVGPLYSGCR 14950 14960 14970 14980 14990 15000 LTLLRPEKQE AATGVDTICT HRVDPIGPGL DRERLYWELS QLTNSITELG PYTLDRDSLY 15010 15020 15030 15040 15050 15060 VNGFNPWSSV PTTSTPGTST VHLATSGTPS SLPGHTAPVP LLIPFTLNFT ITDLHYEENM 15070 15080 15090 15100 15110 15120 QHPGSRKFNT TERVLQGLLK PLFKSTSVGP LYSGCRLTLL RPEKHGAATG VDAICTLRLD 15130 15140 15150 15160 15170 15180 PTGPGLDRER LYWELSQLTN SVTELGPYTL DRDSLYVNGF THRSSVPTTS IPGTSAVHLE 15190 15200 15210 15220 15230 15240 TSGTPASLPG HTAPGPLLVP FTLNFTITNL QYEEDMRHPG SRKFSTTERV LQGLLKPLFK 15250 15260 15270 15280 15290 15300 NTSVSSLYSG CRLTLLRPEK DGAATRVDAV CTHRPDPKSP GLDRERLYWK LSQLTHGITE 15310 15320 15330 15340 15350 15360 LGPYTLDRHS LYVNGFTHQS SMTTTRTPDT STMHLATSRT PASLSGPTTA SPLLVLFTIN 15370 15380 15390 15400 15410 15420 FTITNLRYEE NMHHPGSRKF NTTERVLQGL LRPVFKNTSV GPLYSGCRLT TLRPKKDGAA 15430 15440 15450 15460 15470 15480 TKVDAICTYR PDPKSPGLDR EQLYWELSQL THSITELGPY TQDRDSLYVN GFTHRSSVPT 15490 15500 15510 15520 15530 15540 TSIPGTSAVH LETSGTPASL PGHTAPGPLL VPFTLNFTIT NLQYEEDMRH PGSRKFNTTE 15550 15560 15570 15580 15590 15600 RVLQGLLKPL FKSTSVGPLY SGCRLTLLRP EKRGAATGVD TICTHRLDPL NPGLDREQLY 15610 15620 15630 15640 15650 15660 WELSKLTRGI IELGPYLLDR GSLYVNGFTH RTSVPTTSTP GTSTVDLGTS GTPFSLPSPA 15670 15680 15690 15700 15710 15720 XXXPLLXPFT XNXTITNLXX XXXMXXPGSR KFNTTERVLQ TLLGPMFKNT SVGLLYSGCR 15730 15740 15750 15760 15770 15780 LTLLRSEKDG AATGVDAICT HRLDPKSPGV DREQLYWELS QLTNGIKELG PYTLDRNSLY 15790 15800 15810 15820 15830 15840 VNGFTHWIPV PTSSTPGTST VDLGSGTPSS LPSPTTAGPL LVPFTLNFTI TNLKYEEDMH 15850 15860 15870 15880 15890 15900 CPGSRKFNTT ERVLQSLLGP MFKNTSVGPL YSGCRLTLLR SEKDGAATGV DAICTHRLDP 15910 15920 15930 15940 15950 15960 KSPGVDREQL YWELSQLTNG IKELGPYTLD RNSLYVNGFT HQTSAPNTST PGTSTVDLGT 15970 15980 15990 16000 16010 16020 SGTPSSLPSP TXXXPLLXPF TXNXTITNLX XXXXMXXPGS RKFNTTEXVL QGLLXPXFKN 16030 16040 16050 16060 16070 16080 XSVGXLYSGC RLTXLRXEKX GAATGXDAIC XHXXXPKXPG LXXEXLYWEL SXLTXXIXEL 16090 16100 16110 16120 16130 16140 GPYTLDRXSL YVNGFTHWIP VPTSSTPGTS TVDLGSGTPS SLPSPTTAGP LLVPFTLNFT 16150 16160 16170 16180 16190 16200 ITNLKYEEDM HCPGSRKFNT TERVLQSLLG PMFKNTSVGP LYSGCRLTSL RSEKDGAATG 16210 16220 16230 16240 16250 16260 VDAICTHRVD PKSPGVDREQ LYWELSQLTN GIKELGPYTL DRNSLYVNGF THQTSAPNTS 16270 16280 16290 16300 16310 16320 TPGTSTVXXG TSGTPSSXPX XTSAGPLLVP FTLNFTITNL QYEEDMHHPG SRKFNTTERV 16330 16340 16350 16360 16370 16380 LQGLLGPMFK NTSVGLLYSG CRLTLLRPEK NGATTGMDAI CTHRLDPKSP GLXXEXLYWE 16390 16400 16410 16420 16430 16440 LSXLTXXIXE LGPYTLDRXS LYVNGFTHXX SXPTTSTPGT STVXXGTSGT PSSXPXXTXX 16450 16460 16470 16480 16490 16500 XPLLXPFTXN XTITNLXXXX XMXXPGSRKF NTTERVLQGL LKPLFRNSSL EYLYSGCRLA 16510 16520 16530 16540 16550 16560 SLRPEKDSSA MAVDAICTHR PDPEDLGLDR ERLYWELSNL TNGIQELGPY TLDRNSLYVN 16570 16580 16590 16600 16610 16620 GFTHRSSMPT TSTPGTSTVD VGTSGTPSSS PSPTTAGPLL IPFTLNFTIT NLQYGEDMGH 16630 16640 16650 16660 16670 16680 PGSRKFNTTE RVLQGLLGPI FKNTSVGPLY SGCRLTSLRS EKDGAATGVD AICIHHLDPK 16690 16700 16710 16720 16730 16740 SPGLNRERLY WELSQLTNGI KELGPYTLDR NSLYVNGFTH RTSVPTTSTP GTSTVDLGTS 16750 16760 16770 16780 16790 16800 GTPFSLPSPA TAGPLLVLFT LNFTITNLKY EEDMHRPGSR KFNTTERVLQ TLLGPMFKNT 16810 16820 16830 16840 16850 16860 SVGLLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGL XXEXLYWELS XLTXXIXELG 16870 16880 16890 16900 16910 16920 PYTLDRXSLY VNGFTHXXSX PTTSTPGTST VXXGTSGTPS SXPXXTXXXP LLXPFTXNXT 16930 16940 16950 16960 16970 16980 ITNLXXXXXM XXPGSRKFNT TERVLQGLLR PVFKNTSVGP LYSGCRLTLL RPKKDGAATK 16990 17000 17010 17020 17030 17040 VDAICTYRPD PKSPGLDREQ LYWELSQLTH SITELGPYTQ DRDSLYVNGF THRSSVPTTS 17050 17060 17070 17080 17090 17100 IPGTSAVHLE TTGTPSSFPG HTEPGPLLIP FTFNFTITNL RYEENMQHPG SRKFNTTERV 17110 17120 17130 17140 17150 17160 LQGLLTPLFK NTSVGPLYSG CRLTLLRPEK QEAATGVDTI CTHRVDPIGP GLDRERLYWE 17170 17180 17190 17200 17210 17220 LSQLTNSITE LGPYTLDRDS LYVDGFNPWS SVPTTSTPGT STVHLATSGT PSPLPGHTAP 17230 17240 17250 17260 17270 17280 VPLLIPFTLN FTITDLHYEE NMQHPGSRKF NTTERVLQGL LKPLFKSTSV GPLYSGCRLT 17290 17300 17310 17320 17330 17340 LLRPEKHGAA TGVDAICTLR LDPTGPGLDR ERLYWELSQL TNSITELGPY TLDRDSLYVN 17350 17360 17370 17380 17390 17400 GFNPWSSVPT TSTPGTSTVH LATSGTPSSL PGHTTAGPLL VPFTLNFTIT NLKYEEDMHC 17410 17420 17430 17440 17450 17460 PGSRKFNTTE RVLQSLHGPM FKNTSVGPLY SGCRLTLLRS EKDGAATGVD AICTHRLDPK 17470 17480 17490 17500 17510 17520 SPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH XXSXPTTSTP GTSTVXXGTS 17530 17540 17550 17560 17570 17580 GTPSSXPXXT XXXPLLXPFT XNXTITNLXX XXXMXXPGSR KFNTTEXVLQ GLLXPXFKNX 17590 17600 17610 17620 17630 17640 SVGXLYSGCR LTXLRXEKXG AATGXDAICX HXXXPKXPGL XXEXLYWELS XLTNSITELG 17650 17660 17670 17680 17690 17700 PYTLDRDSLY VNGFTHRSSM PTTSIPGTSA VHLETSGTPA SLPGHTAPGP LLVPFTLNFT 17710 17720 17730 17740 17750 17760 ITNLQYEEDM RHPGSRKFNT TERVLQGLLK PLFKSTSVGP LYSGCRLTLL RPEKRGAATG 17770 17780 17790 17800 17810 17820 VDTICTHRLD PLNPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THXXSXPTTS 17830 17840 17850 17860 17870 17880 TPGTSTVXXG TSGTPSSXPX XTXXXPLLXP FTXNXTITNL XXXXXMXXPG SRKFNTTEXV 17890 17900 17910 17920 17930 17940 LQGLLXPXFK NXSVGXLYSG CRLTXLRXEK XGAATGXDAI CXHXXXPKXP GLXXEXLYWE 17950 17960 17970 17980 17990 18000 LSXLTXXIXE LGPYTLDRXS LYVNGFHPRS SVPTTSTPGT STVHLATSGT PSSLPGHTAP 18010 18020 18030 18040 18050 18060 VPLLIPFTLN FTITNLHYEE NMQHPGSRKF NTTERVLQGL LGPMFKNTSV GLLYSGCRLT 18070 18080 18090 18100 18110 18120 LLRPEKNGAA TGMDAICSHR LDPKSPGLXX EXLYWELSXL TXXIXELGPY TLDRXSLYVN 18130 18140 18150 18160 18170 18180 GFTHXXSXPT TSTPGTSTVX XGTSGTPSSX PXXTXXXPLL XPFTXNXTIT NLXXXXXMXX 18190 18200 18210 18220 18230 18240 PGSRKFNTTE XVLQGLLXPX FKNXSVGXLY SGCRLTXLRX EKXGAATGXD AICXHXXXPK 18250 18260 18270 18280 18290 18300 XPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH QNSVPTTSTP GTSTVYWATT 18310 18320 18330 18340 18350 18360 GTPSSFPGHT EPGPLLIPFT FNFTITNLHY EENMQHPGSR KFNTTERVLQ GLLTPLFKNT 18370 18380 18390 18400 18410 18420 SVGPLYSGCR LTLLRPEKQE AATGVDTICT HRVDPIGPGL XXEXLYWELS XLTXXIXELG 18430 18440 18450 18460 18470 18480 PYTLDRXSLY VNGFTHXXSX PTTSTPGTST VXXGTSGTPS SXPXXTXXXP LLXPFTXNXT 18490 18500 18510 18520 18530 18540 ITNLXXXXXM XXPGSRKFNT TEXVLQGLLX PXFKNXSVGX LYSGCRLTXL RXEKXGAATG 18550 18560 18570 18580 18590 18600 XDAICXHXXX PKXPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THRSSVPTTS 18610 18620 18630 18640 18650 18660 SPGTSTVHLA TSGTPSSLPG HTAPVPLLIP FTLNFTITNL HYEENMQHPG SRKFNTTERV 18670 18680 18690 18700 18710 18720 LQGLLKPLFK STSVGPLYSG CRLTLLRPEK HGAATGVDAI CTLRLDPTGP GLXXEXLYWE 18730 18740 18750 18760 18770 18780 LSXLTXXIXE LGPYTLDRXS LYVNGFTHXX SXPTTSTPGT STVXXGTSGT PSSXPXXTXX 18790 18800 18810 18820 18830 18840 XPLLXPFTXN XTITNLXXXX XMXXPGSRKF NTTEXVLQGL LXPXFKNXSV GXLYSGCRLT 18850 18860 18870 18880 18890 18900 XLRXEKXGAA TGXDAICXHX XXPKXPGLXX EXLYWELSXL TXXIXELGPY TLDRXSLYVN 18910 18920 18930 18940 18950 18960 GFTHRTSVPT TSTPGTSTVH LATSGTPSSL PGHTAPVPLL IPFTLNFTIT NLQYEEDMHR 18970 18980 18990 19000 19010 19020 PGSRKFNTTE RVLQGLLSPI FKNSSVGPLY SGCRLTSLRP EKDGAATGMD AVCLYHPNPK 19030 19040 19050 19060 19070 19080 RPGLDREQLY CELSQLTHNI TELGPYSLDR DSLYVNGFTH QNSVPTTSTP GTSTVYWATT 19090 19100 19110 19120 19130 19140 GTPSSFPGHT XXXPLLXPFT XNXTITNLXX XXXMXXPGSR KFNTTEXVLQ GLLXPXFKNX 19150 19160 19170 19180 19190 19200 SVGXLYSGCR LTXLRXEKXG AATGXDAICX HXXXPKXPGL XXEXLYWELS XLTXXIXELG 19210 19220 19230 19240 19250 19260 PYTLDRXSLY VNGFTHWSSG LTTSTPWTST VDLGTSGTPS PVPSPTTAGP LLVPFTLNFT 19270 19280 19290 19300 19310 19320 ITNLQYEEDM HRPGSRKFNA TERVLQGLLS PIFKNTSVGP LYSGCRLTLL RPEKQEAATG 19330 19340 19350 19360 19370 19380 VDTICTHRVD PIGPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THXXSXPTTS 19390 19400 19410 19420 19430 19440 TPGTSTVXXG TSGTPSSXPX XTXXXPLLXP FTXNXTITNL XXXXXMXXPG SRKFNTTEXV 19450 19460 19470 19480 19490 19500 LQGLLXPXFK NXSVGXLYSG CRLTXLRXEK XGAATGXDAI CXHXXXPKXP GLXXEXLYWE 19510 19520 19530 19540 19550 19560 LSXLTXXIXE LGPYTLDRXS LYVNGFTHRS FGLTTSTPWT STVDLGTSGT PSPVPSPTTA 19570 19580 19590 19600 19610 19620 GPLLVPFTLN FTITNLQYEE DMHRPGSRKF NTTERVLQGL LTPLFRNTSV SSLYSGCRLT 19630 19640 19650 19660 19670 19680 LLRPEKDGAA TRVDAVCTHR PDPKSPGLXX EXLYWELSXL TXXIXELGPY TLDRXSLYVN 19690 19700 19710 19720 19730 19740 GFTHXXSXPT TSTPGTSTVX XGTSGTPSSX PXXTXXXPLL XPFTXNXTIT NLXXXXXMXX 19750 19760 19770 19780 19790 19800 PGSRKFNTTE XVLQGLLXPX FKNXSVGXLY SGCRLTXLRX EKXGAATGXD AICXHXXXPK 19810 19820 19830 19840 19850 19860 XPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH WIPVPTSSTP GTSTVDLGSG 19870 19880 19890 19900 19910 19920 TPSSLPSPTT AGPLLVPFTL NFTITNLQYG EDMGHPGSRK FNTTERVLQG LLGPIFKNTS 19930 19940 19950 19960 19970 19980 VGPLYSGCRL TSLRSEKDGA ATGVDAICIH HLDPKSPGLX XEXLYWELSX LTXXIXELGP 19990 20000 20010 20020 20030 20040 YTLDRXSLYV NGFTHXXSXP TTSTPGTSTV XXGTSGTPSS XPXXTXXXPL LXPFTXNXTI 20050 20060 20070 20080 20090 20100 TNLXXXXXMX XPGSRKFNTT EXVLQGLLXP XFKNXSVGXL YSGCRLTXLR XEKXGAATGX 20110 20120 20130 20140 20150 20160 DAICXHXXXP KXPGLXXEXL YWELSXLTXX IXELGPYTLD RXSLYVNGFT HQTFAPNTST 20170 20180 20190 20200 20210 20220 PGTSTVDLGT SGTPSSLPSP TSAGPLLVPF TLNFTITNLQ YEEDMHHPGS RKFNTTERVL 20230 20240 20250 20260 20270 20280 QGLLGPMFKN TSVGLLYSGC RLTLLRPEKN GAATRVDAVC THRPDPKSPG LXXEXLYWEL 20290 20300 20310 20320 20330 20340 SXLTXXIXEL GPYTLDRXSL YVNGFTHXXS XPTTSTPGTS TVXXGTSGTP SSXPXXTAPV 20350 20360 20370 20380 20390 20400 PLLIPFTLNF TITNLHYEEN MQHPGSRKFN TTERVLQGLL KPLFKSTSVG PLYSGCRLTL 20410 20420 20430 20440 20450 20460 LRPEKHGAAT GVDAICTLRL DPTGPGLDRE RLYWELSQLT NSVTELGPYT LDRDSLYVNG 20470 20480 20490 20500 20510 20520 FTQRSSVPTT SIPGTSAVHL ETSGTPASLP GHTAPGPLLV PFTLNFTITN LQYEVDMRHP 20530 20540 20550 20560 20570 20580 GSRKFNTTER VLQGLLKPLF KSTSVGPLYS GCRLTLLRPE KRGAATGVDT ICTHRLDPLN 20590 20600 20610 20620 20630 20640 PGLDREQLYW ELSKLTRGII ELGPYLLDRG SLYVNGFTHR NFVPITSTPG TSTVHLGTSE 20650 20660 20670 20680 20690 20700 TPSSLPRPIV PGPLLVPFTL NFTITNLQYE EAMRHPGSRK FNTTERVLQG LLRPLFKNTS 20710 20720 20730 20740 20750 20760 IGPLYSSCRL TLLRPEKDKA ATRVDAICTH HPDPQSPGLN REQLYWELSQ LTHGITELGP 20770 20780 20790 20800 20810 20820 YTLDRDSLYV DGFTHWSPIP TTSTPGTSIV NLGTSGIPPS LPETTXXXPL LXPFTXNXTI 20830 20840 20850 20860 20870 20880 TNLXXXXXMX XPGSRKFNTT ERVLQGLLKP LFKSTSVGPL YSGCRLTLLR PEKDGVATRV 20890 20900 20910 20920 20930 20940 DAICTHRPDP KIPGLDRQQL YWELSQLTHS ITELGPYTLD RDSLYVNGFT QRSSVPTTST 20950 20960 20970 20980 20990 21000 PGTFTVQPET SETPSSLPGP TATGPVLLPF TLNFTITNLQ YEEDMHRPGS RKFNTTERVL 21010 21020 21030 21040 21050 21060 QGLLMPLFKN TSVSSLYSGC RLTLLRPEKD GAATRVDAVC THRPDPKSPG LDRERLYWKL 21070 21080 21090 21100 21110 21120 SQLTHGITEL GPYTLDRHSL YVNGFTHQSS MTTTRTPDTS TMHLATSRTP ASLSGPTTAS 21130 21140 21150 21160 21170 21180 PLLVLFTINF TITNLRYEEN MHHPGSRKFN TTERVLQGLL RPVFKNTSVG PLYSGCRLTL 21190 21200 21210 21220 21230 21240 LRPKKDGAAT KVDAICTYRP DPKSPGLDRE QLYWELSQLT HSITELGPYT LDRDSLYVNG 21250 21260 21270 21280 21290 21300 FTQRSSVPTT SIPGTPTVDL GTSGTPVSKP GPSAASPLLV LFTLNFTITN LRYEENMQHP 21310 21320 21330 21340 21350 21360 GSRKFNTTER VLQGLLRSLF KSTSVGPLYS GCRLTLLRPE KDGTATGVDA ICTHHPDPKS 21370 21380 21390 21400 21410 21420 PRLDREQLYW ELSQLTHNIT ELGHYALDND SLFVNGFTHR SSVSTTSTPG TPTVYLGASK 21430 21440 21450 21460 21470 21480 TPASIFGPSA ASHLLILFTL NFTITNLRYE ENMWPGSRKF NTTERVLQGL LRPLFKNTSV 21490 21500 21510 21520 21530 21540 GPLYSGSRLT LLRPEKDGEA TGVDAICTHR PDPTGPGLDR EQLYLELSQL THSITELGPY 21550 21560 21570 21580 21590 21600 TLDRDSLYVN GFTHRSSVPT TSTGVVSEEP FTLNFTINNL RYMADMGQPG SLKFNITDNV 21610 21620 21630 21640 21650 21660 MKHLLSPLFQ RSSLGARYTG CRVIALRSVK NGAETRVDLL CTYLQPLSGP GLPIKQVFHE 21670 21680 21690 21700 21710 21720 LSQQTHGITR LGPYSLDKDS LYLNGYNEPG LDEPPTTPKP ATTFLPPLSE ATTAMGYHLK 21730 21740 21750 21760 21770 21780 TLTLNFTISN LQYSPDMGKG SATFNSTEGV LQHLLRPLFQ KSSMGPFYLG CQLISLRPEK 21790 21800 21810 21820 21830 21840 DGAATGVDTT CTYHPDPVGP GLDIQQLYWE LSQLTHGVTQ LGFYVLDRDS LFINGYAPQN 21850 21860 21870 21880 21890 21900 LSIRGEYQIN FHIVNWNLSN PDPTSSEYIT LLRDIQDKVT TLYKGSQLHD TFRFCLVTNL 21910 21920 21930 21940 21950 21960 TMDSVLVTVK ALFSSNLDPS LVEQVFLDKT LNASFHWLGS TYQLVDIHVT EMESSVYQPT 21970 21980 21990 22000 22010 22020 SSSSTQHFYL NFTITNLPYS QDKAQPGTTN YQRNKRNIED ALNQLFRNSS IKSYFSDCQV 22030 22040 22050 22060 22070 22080 STFRSVPNRH HTGVDSLCNF SPLARRVDRV AIYEEFLRMT RNGTQLQNFT LDRSSVLVDG 22090 22100 22110 22120 22130 22140 YSPNRNEPLT GNSDLPFWAV ILIGLAGLLG LITCLICGVL VTTRRRKKEG EYNVQQQCPG 22150 YYQSHLDLED LQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure." O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K. Tumor Biol. 23:154-169(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-10431, SEQUENCE REVISION TO N-TERMINUS, TISSUE SPECIFICITY, INDUCTION.
[2]	"The CA 125 gene: an extracellular superstructure dominated by repeat sequences." O'Brien T.J., Beard J.B., Underwood L.J., Dennis R.A., Santin A.D., York L. Tumor Biol. 22:348-366(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10432-22152.
[3]	"Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16." Yin B.W.T., Lloyd K.O. J. Biol. Chem. 276:27371-27375(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8297-22152, PROTEIN SEQUENCE OF 21360-21365 AND 21983-21995, TISSUE SPECIFICITY.
[4]	Lloyd K.O., Yin B.W.T. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20473-21695. Tissue: Uterus.
[6]	"CA125 phosphorylation is associated with its secretion from the WISH human amnion cell line." Fendrick J.L., Konishi I., Geary S.M., Parmley T.H., Quirk J.G. Jr., O'Brien T.J. Tumor Biol. 18:278-289(1997) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION.
[7]	"Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125." Kui Wong N., Easton R.L., Panico M., Sutton-Smith M., Morrison J.C., Lattanzio F.A., Morris H.R., Clark G.F., Dell A., Patankar M.S. J. Biol. Chem. 278:28619-28634(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION.
[8]	"Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion." Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., Miyajima A. J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MSLN.
[9]	"Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer." McLemore M.R., Aouizerat B. Biol. Res. Nurs. 6:262-267(2005) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW, POLYMORPHISM.
[10]	"Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye." Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K. Invest. Ophthalmol. Vis. Sci. 47:113-119(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Mucin database

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF414442 mRNA. Translation: AAL65133.2. AF361486 mRNA. Translation: AAK74120.3. AK128681 mRNA. Translation: BAC87568.1.
IPI	IPI00103552.
RefSeq	NP_078966.2. NM_024690.2.
UniGene	Hs.432676.
3D structure databases
ProteinModelPortal	Q8WXI7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000381008.
PTM databases
PhosphoSite	Q8WXI7.
Polymorphism databases
DMDM	74716283.
Proteomic databases
PaxDb	Q8WXI7.
PRIDE	Q8WXI7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	94025.
KEGG	hsa:94025.
Organism-specific databases
CTD	94025.
GeneCards	GC19M008960.
H-InvDB	HIX0021715.
HGNC	HGNC:15582. MUC16.
HPA	CAB055172. HPA026659. HPA050015.
MIM	606154. gene.
neXtProt	NX_Q8WXI7.
PharmGKB	PA31314.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
KO	K16145.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
CleanEx	HS_MUC16.
Genevestigator	Q8WXI7.
Family and domain databases
InterPro	IPR000082. SEA. [Graphical view]
Pfam	PF01390. SEA. 55 hits. [Graphical view]
SMART	SM00200. SEA. 23 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. False negative. PS50088. ANK_REPEAT. False negative. PS50024. SEA. 11 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MUC16. human.
GenomeRNAi	94025.
NextBio	78314.
SOURCE	Search...

Entry information

Entry name

MUC16_HUMAN

Accession

Primary (citable) accession number: Q8WXI7
Secondary accession number(s): Q6ZQW5, Q96RK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.