Reviewed,
UniProtKB/Swiss-Prot Q8WXI7 (MUC16_HUMAN)
Last modified
June 16, 2009.
Version 47.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Mucin-16 Short name=MUC-16 Alternative name(s): Ovarian carcinoma antigen CA125 Ovarian cancer-related tumor marker CA125 Short name=CA-125 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 22152 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces By similarity. |
| Subunit structure | Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN. Ref.8 |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. Secreted › extracellular space. Note: May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain. |
| Tissue specificity | Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. Ref.1 Ref.3 Ref.10 |
| Induction | Up-regulated in ovarian cancer cells. Ref.1 |
| Domain | Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail. |
| Post-translational modification | Heavily O-glycosylated; expresses both type 1 and type 2 core glycans. Ref.7 Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans. Ref.7 May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. Ref.6 May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts. |
| Polymorphism | The number of repeats is highly polymorphic. |
| Miscellaneous | Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening. |
| Sequence similarities | Contains 2 ANK repeats. Contains 14 LRR (leucine-rich) repeats. Contains 56 SEA domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | ANK repeat Leucine-rich repeat Repeat Transmembrane |
| PTM | Disulfide bond Glycoprotein Phosphoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | cell adhesion Ref.8 Non-traceable author statement. Source: UniProtKB |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membraneInferred from direct assay. Source: UniProtKB integral to membraneInferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Ref.8 Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 22152 | 22152 | Mucin-16 | PRO_0000259595 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 22096 | 22096 | Extracellular Potential | ||||||||
| Transmembrane | 22097 – 22117 | 21 | Potential | ||||||||
| Topological domain | 22118 – 22152 | 35 | Cytoplasmic Potential | ||||||||
| Repeat | 7230 – 7253 | 24 | LRR 1 | ||||||||
| Repeat | 11276 – 11301 | 26 | LRR 2 | ||||||||
| Domain | 12070 – 12190 | 121 | SEA 1 | ||||||||
| Repeat | 12176 – 12201 | 26 | LRR 3 | ||||||||
| Domain | 12229 – 12339 | 111 | SEA 2 | ||||||||
| Repeat | 12332 – 12356 | 25 | LRR 4 | ||||||||
| Domain | 12386 – 12504 | 119 | SEA 3 | ||||||||
| Repeat | 12490 – 12514 | 25 | LRR 5 | ||||||||
| Domain | 12539 – 12660 | 122 | SEA 4 | ||||||||
| Repeat | 12650 – 12674 | 25 | LRR 6 | ||||||||
| Domain | 12697 – 12815 | 119 | SEA 5 | ||||||||
| Domain | 12853 – 12971 | 119 | SEA 6 | ||||||||
| Domain | 13009 – 13127 | 119 | SEA 7 | ||||||||
| Domain | 13165 – 13283 | 119 | SEA 8 | ||||||||
| Domain | 13315 – 13439 | 125 | SEA 9 | ||||||||
| Domain | 13477 – 13595 | 119 | SEA 10 | ||||||||
| Domain | 13633 – 13751 | 119 | SEA 11 | ||||||||
| Repeat | 13767 – 13801 | 35 | ANK 1 | ||||||||
| Domain | 13789 – 13907 | 119 | SEA 12 | ||||||||
| Domain | 13939 – 14063 | 125 | SEA 13 | ||||||||
| Domain | 14101 – 14219 | 119 | SEA 14 | ||||||||
| Repeat | 14209 – 14232 | 24 | LRR 7 | ||||||||
| Domain | 14251 – 14375 | 125 | SEA 15 | ||||||||
| Domain | 14410 – 14531 | 122 | SEA 16 | ||||||||
| Repeat | 14517 – 14541 | 25 | LRR 8 | ||||||||
| Domain | 14567 – 14689 | 123 | SEA 17 | ||||||||
| Domain | 14723 – 14845 | 123 | SEA 18 | ||||||||
| Repeat | 14835 – 14858 | 24 | LRR 9 | ||||||||
| Domain | 14877 – 15001 | 125 | SEA 19 | ||||||||
| Domain | 15039 – 15157 | 119 | SEA 20 | ||||||||
| Domain | 15195 – 15313 | 119 | SEA 21 | ||||||||
| Domain | 15348 – 15469 | 122 | SEA 22 | ||||||||
| Domain | 15507 – 15625 | 119 | SEA 23 | ||||||||
| Domain | 15664 – 15774 | 111 | SEA 24 | ||||||||
| Repeat | 15771 – 15795 | 25 | LRR 10 | ||||||||
| Domain | 15812 – 15936 | 125 | SEA 25 | ||||||||
| Repeat | 15922 – 15946 | 25 | LRR 11 | ||||||||
| Domain | 16123 – 16247 | 125 | SEA 26 | ||||||||
| Repeat | 16233 – 16257 | 25 | LRR 12 | ||||||||
| Domain | 16279 – 16403 | 125 | SEA 27 | ||||||||
| Domain | 16437 – 16559 | 123 | SEA 28 | ||||||||
| Repeat | 16545 – 16570 | 26 | LRR 13 | ||||||||
| Domain | 16591 – 16715 | 125 | SEA 29 | ||||||||
| Repeat | 16701 – 16725 | 25 | LRR 14 | ||||||||
| Domain | 16750 – 16871 | 122 | SEA 30 | ||||||||
| Domain | 16905 – 17027 | 123 | SEA 31 | ||||||||
| Domain | 17065 – 17183 | 119 | SEA 32 | ||||||||
| Domain | 17221 – 17339 | 119 | SEA 33 | ||||||||
| Domain | 17378 – 17488 | 111 | SEA 34 | ||||||||
| Domain | 17534 – 17644 | 111 | SEA 35 | ||||||||
| Domain | 17689 – 17807 | 119 | SEA 36 | ||||||||
| Domain | 18001 – 18119 | 119 | SEA 37 | ||||||||
| Domain | 18313 – 18431 | 119 | SEA 38 | ||||||||
| Domain | 18625 – 18743 | 119 | SEA 39 | ||||||||
| Repeat | 18915 – 18949 | 35 | ANK 2 | ||||||||
| Domain | 18937 – 19055 | 119 | SEA 40 | ||||||||
| Domain | 19243 – 19367 | 125 | SEA 41 | ||||||||
| Domain | 19555 – 19679 | 125 | SEA 42 | ||||||||
| Domain | 19866 – 19990 | 125 | SEA 43 | ||||||||
| Domain | 20184 – 20302 | 119 | SEA 44 | ||||||||
| Domain | 20340 – 20458 | 119 | SEA 45 | ||||||||
| Domain | 20496 – 20614 | 119 | SEA 46 | ||||||||
| Domain | 20652 – 20770 | 119 | SEA 47 | ||||||||
| Domain | 20804 – 20926 | 123 | SEA 48 | ||||||||
| Domain | 20964 – 21082 | 119 | SEA 49 | ||||||||
| Domain | 21117 – 21238 | 122 | SEA 50 | ||||||||
| Domain | 21273 – 21394 | 122 | SEA 51 | ||||||||
| Domain | 21433 – 21542 | 110 | SEA 52 | ||||||||
| Domain | 21565 – 21683 | 119 | SEA 53 | ||||||||
| Domain | 21717 – 21826 | 110 | SEA 54 | ||||||||
| Domain | 21836 – 21957 | 122 | SEA 55 | ||||||||
| Domain | 21959 – 22080 | 122 | SEA 56 | ||||||||
| Compositional bias | 14 – 12085 | 12072 | Thr-rich | ||||||||
| Compositional bias | 1638 – 3055 | 1418 | Ser-rich | ||||||||
| Compositional bias | 3961 – 4385 | 425 | Ser-rich | ||||||||
| Compositional bias | 7085 – 10395 | 3311 | Ser-rich | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 139 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 434 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 787 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 930 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 957 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1375 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1633 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1840 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1877 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1890 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2345 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2375 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2737 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3086 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3179 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3502 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4222 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4500 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4608 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4615 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4626 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4863 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 5098 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 5133 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 5230 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 5322 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 5396 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 5472 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 5691 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 5865 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 6090 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 6734 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 6861 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 6963 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 8031 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 8057 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 8326 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 8620 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 8686 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 8915 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 9204 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 9495 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 9787 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 9920 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 10077 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 10175 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 10512 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 10702 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 10751 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 11055 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 11226 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 11265 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 11369 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 11596 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12081 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12102 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12118 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12170 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12237 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12274 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12395 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12416 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12432 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12551 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12572 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12588 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12706 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12727 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12743 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12826 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12862 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12883 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 12982 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13018 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13039 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13055 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13174 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13195 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13211 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13330 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13351 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13367 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13423 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13486 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13507 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13523 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13579 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13642 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13663 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13679 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13798 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13819 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13835 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13954 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13975 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 13991 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14110 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14131 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14147 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14266 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14287 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14303 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14359 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14422 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14459 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14580 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14601 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14617 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14736 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14757 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14773 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14825 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14892 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14913 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 14929 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15048 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15069 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15204 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15241 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15360 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15381 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15397 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15516 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15537 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15672 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15693 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15709 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15827 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15848 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15864 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15947 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 15983 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16004 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16020 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16138 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16159 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16175 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16258 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16294 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16315 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16331 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16450 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16471 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16487 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16539 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16606 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16627 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16643 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16762 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16783 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16799 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16918 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16939 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 16955 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17074 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17095 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17111 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17230 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17251 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17386 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17407 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17423 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17542 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17563 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17579 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17698 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17719 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17854 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17875 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 17891 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18010 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18031 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18047 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18166 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18187 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18203 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18322 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18343 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18359 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18478 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18499 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18515 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18634 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18655 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18790 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18811 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18827 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18946 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18967 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 18983 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19039 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19102 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19123 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19139 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19258 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19279 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19295 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19414 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19435 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19451 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19570 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19591 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19607 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19726 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19747 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19763 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19881 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19902 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 19918 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20037 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20058 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20074 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20157 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20193 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20214 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20230 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20349 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20370 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20505 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20526 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20661 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20682 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20698 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20817 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20838 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20973 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 20994 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21010 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21129 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21150 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21166 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21285 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21306 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21378 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21389 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21441 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21461 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21477 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21574 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21595 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21725 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21745 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21840 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21857 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21899 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21932 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 21971 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 22008 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 22062 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 22068 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 12128 ↔ 12148 | Potential | |||||||||
| Disulfide bond | 12284 ↔ 12304 | Potential | |||||||||
| Disulfide bond | 12442 ↔ 12462 | Potential | |||||||||
| Disulfide bond | 12598 ↔ 12618 | Potential | |||||||||
| Disulfide bond | 12753 ↔ 12773 | Potential | |||||||||
| Disulfide bond | 12909 ↔ 12929 | Potential | |||||||||
| Disulfide bond | 13065 ↔ 13085 | Potential | |||||||||
| Disulfide bond | 13221 ↔ 13241 | Potential | |||||||||
| Disulfide bond | 13377 ↔ 13397 | Potential | |||||||||
| Disulfide bond | 13533 ↔ 13553 | Potential | |||||||||
| Disulfide bond | 13689 ↔ 13709 | Potential | |||||||||
| Disulfide bond | 13845 ↔ 13865 | Potential | |||||||||
| Disulfide bond | 14001 ↔ 14021 | Potential | |||||||||
| Disulfide bond | 14157 ↔ 14177 | Potential | |||||||||
| Disulfide bond | 14313 ↔ 14333 | Potential | |||||||||
| Disulfide bond | 14469 ↔ 14489 | Potential | |||||||||
| Disulfide bond | 14627 ↔ 14647 | Potential | |||||||||
| Disulfide bond | 14783 ↔ 14803 | Potential | |||||||||
| Disulfide bond | 14939 ↔ 14959 | Potential | |||||||||
| Disulfide bond | 15095 ↔ 15115 | Potential | |||||||||
| Disulfide bond | 15251 ↔ 15271 | Potential | |||||||||
| Disulfide bond | 15407 ↔ 15427 | Potential | |||||||||
| Disulfide bond | 15563 ↔ 15583 | Potential | |||||||||
| Disulfide bond | 15719 ↔ 15739 | Potential | |||||||||
| Disulfide bond | 15874 ↔ 15894 | Potential | |||||||||
| Disulfide bond | 16185 ↔ 16205 | Potential | |||||||||
| Disulfide bond | 16341 ↔ 16361 | Potential | |||||||||
| Disulfide bond | 16497 ↔ 16517 | Potential | |||||||||
| Disulfide bond | 16653 ↔ 16673 | Potential | |||||||||
| Disulfide bond | 16809 ↔ 16829 | Potential | |||||||||
| Disulfide bond | 16965 ↔ 16985 | Potential | |||||||||
| Disulfide bond | 17121 ↔ 17141 | Potential | |||||||||
| Disulfide bond | 17277 ↔ 17297 | Potential | |||||||||
| Disulfide bond | 17433 ↔ 17453 | Potential | |||||||||
| Disulfide bond | 17589 ↔ 17609 | Potential | |||||||||
| Disulfide bond | 17745 ↔ 17765 | Potential | |||||||||
| Disulfide bond | 18057 ↔ 18077 | Potential | |||||||||
| Disulfide bond | 18369 ↔ 18389 | Potential | |||||||||
| Disulfide bond | 18681 ↔ 18701 | Potential | |||||||||
| Disulfide bond | 18993 ↔ 19013 | Potential | |||||||||
| Disulfide bond | 19305 ↔ 19325 | Potential | |||||||||
| Disulfide bond | 19617 ↔ 19637 | Potential | |||||||||
| Disulfide bond | 19928 ↔ 19948 | Potential | |||||||||
| Disulfide bond | 20396 ↔ 20416 | Potential | |||||||||
| Disulfide bond | 20552 ↔ 20572 | Potential | |||||||||
| Disulfide bond | 20708 ↔ 20728 | Potential | |||||||||
| Disulfide bond | 20864 ↔ 20884 | Potential | |||||||||
| Disulfide bond | 21020 ↔ 21040 | Potential | |||||||||
| Disulfide bond | 21176 ↔ 21196 | Potential | |||||||||
| Disulfide bond | 21332 ↔ 21352 | Potential | |||||||||
| Disulfide bond | 21621 ↔ 21641 | Potential | |||||||||
| Disulfide bond | 21771 ↔ 21791 | Potential | |||||||||
| Disulfide bond | 22018 ↔ 22038 | Potential | |||||||||
Natural variations | |||||||||||
| Natural variant | 545 | 1 | T → A: dbSNP rs17000957. | VAR_056592 | |||||||
| Natural variant | 1015 | 1 | R → G: dbSNP rs17000950. | VAR_056593 | |||||||
| Natural variant | 1032 | 1 | S → T: dbSNP rs10411228. | VAR_056594 | |||||||
| Natural variant | 1041 | 1 | P → S: dbSNP rs10406202. | VAR_056595 | |||||||
| Natural variant | 1162 | 1 | T → I: dbSNP rs17000947. | VAR_056596 | |||||||
| Natural variant | 1266 | 1 | K → N: dbSNP rs1596797. | VAR_056597 | |||||||
| Natural variant | 1353 | 1 | H → Y: dbSNP rs12611293. | VAR_056598 | |||||||
| Natural variant | 1400 | 1 | K → N: dbSNP rs1596798. | VAR_056599 | |||||||
| Natural variant | 1833 | 1 | L → F: dbSNP rs4520945. | VAR_056600 | |||||||
| Natural variant | 1953 | 1 | S → P: dbSNP rs1108380. | VAR_056601 | |||||||
| Natural variant | 2058 | 1 | S → P: dbSNP rs1574479. | VAR_056602 | |||||||
| Natural variant | 2150 | 1 | I → V: dbSNP rs10407633. | VAR_056603 | |||||||
| Natural variant | 2271 | 1 | T → A: dbSNP rs11085805. | VAR_056604 | |||||||
| Natural variant | 2288 | 1 | V → L: dbSNP rs10410933. | VAR_056605 | |||||||
| Natural variant | 2356 | 1 | D → E: dbSNP rs10416013. | VAR_056606 | |||||||
| Natural variant | 2747 | 1 | A → T: dbSNP rs10402538. | VAR_056607 | |||||||
| Natural variant | 2786 | 1 | M → I: dbSNP rs17000886. | VAR_056608 | |||||||
| Natural variant | 2834 | 1 | T → M: dbSNP rs10407623. | VAR_056609 | |||||||
| Natural variant | 3574 | 1 | R → H: dbSNP rs2591594. | VAR_056610 | |||||||
| Natural variant | 5743 | 1 | H → D: dbSNP rs1559172. | VAR_056611 | |||||||
| Natural variant | 5756 | 1 | A → T: dbSNP rs1559171. | VAR_056612 | |||||||
| Natural variant | 5854 | 1 | F → V: dbSNP rs1862460. | VAR_056613 | |||||||
| Natural variant | 7065 | 1 | T → A: dbSNP rs17000770. | VAR_056614 | |||||||
| Natural variant | 7274 | 1 | I → V: dbSNP rs1867691. | VAR_056615 | |||||||
| Natural variant | 10509 | 1 | T → N: dbSNP rs11670461. | VAR_056616 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 8346 | 1 | D → A in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 8580 | 1 | A → T in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 9061 | 1 | S → T in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 9074 | 1 | A → T in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 9131 | 1 | D → E in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 9407 | 1 | Q → R in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 9504 | 1 | T → A in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 9610 | 1 | S → P in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 9852 | 1 | D → E in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 9901 | 1 | Y → F in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 10171 | 1 | F → L in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 10396 | 1 | T → S in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 10515 | 1 | R → M in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 10522 | 1 | L → P in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 10563 | 1 | L → F in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 10830 | 1 | P → S in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 11156 | 1 | S → F in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 11201 | 1 | A → G in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 11457 | 1 | G → D in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 11506 | 1 | K → R in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 11577 | 1 | V → A in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 11783 | 1 | G → E in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 12142 | 1 | M → T in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 12226 | 1 | A → T in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 12582 | 1 | L → V in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 12629 | 1 | L → V in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 12695 | 1 | A → SAT in AAK74120. Ref.3 | ||||||||
| Sequence conflict | 12713 | 1 | Q → K in | ||||||||