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Q8WXI7

- MUC16_HUMAN

UniProt

Q8WXI7 - MUC16_HUMAN

Protein

Mucin-16

Gene

MUC16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. cellular protein metabolic process Source: Reactome
    3. O-glycan processing Source: Reactome
    4. post-translational protein modification Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucin-16
    Short name:
    MUC-16
    Alternative name(s):
    Ovarian cancer-related tumor marker CA125
    Short name:
    CA-125
    Ovarian carcinoma antigen CA125
    Gene namesi
    Name:MUC16
    Synonyms:CA125
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:15582. MUC16.

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein. Secretedextracellular space
    Note: May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt
    3. extrinsic component of membrane Source: UniProtKB
    4. Golgi lumen Source: Reactome
    5. integral component of membrane Source: UniProtKB-KW
    6. plasma membrane Source: UniProtKB-SubCell
    7. vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31314.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2215222152Mucin-16PRO_0000259595Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi787 – 7871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi930 – 9301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1375 – 13751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1633 – 16331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1840 – 18401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1877 – 18771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1890 – 18901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2345 – 23451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2375 – 23751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2737 – 27371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3086 – 30861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3179 – 31791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3502 – 35021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4222 – 42221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4500 – 45001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4608 – 46081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4615 – 46151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4626 – 46261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4863 – 48631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5098 – 50981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5133 – 51331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5230 – 52301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5322 – 53221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5396 – 53961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5472 – 54721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5691 – 56911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5865 – 58651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi6090 – 60901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi6734 – 67341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi6861 – 68611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi6963 – 69631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi8031 – 80311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi8057 – 80571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi8326 – 83261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi8620 – 86201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi8686 – 86861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi8915 – 89151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi9204 – 92041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi9495 – 94951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi9787 – 97871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi9920 – 99201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10077 – 100771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10175 – 101751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10512 – 105121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10702 – 107021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10751 – 107511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11055 – 110551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11226 – 112261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11265 – 112651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11369 – 113691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11596 – 115961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12081 – 120811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12102 – 121021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12118 – 121181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi12128 ↔ 12148Sequence Analysis
    Glycosylationi12170 – 121701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12237 – 122371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12274 – 122741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi12284 ↔ 12304Sequence Analysis
    Glycosylationi12395 – 123951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12416 – 124161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12432 – 124321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi12442 ↔ 12462Sequence Analysis
    Glycosylationi12551 – 125511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12572 – 125721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12588 – 125881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi12598 ↔ 12618Sequence Analysis
    Glycosylationi12706 – 127061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12727 – 127271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12743 – 127431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi12753 ↔ 12773Sequence Analysis
    Glycosylationi12826 – 128261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12862 – 128621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12883 – 128831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi12909 ↔ 12929Sequence Analysis
    Glycosylationi12982 – 129821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13018 – 130181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13039 – 130391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13055 – 130551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi13065 ↔ 13085Sequence Analysis
    Glycosylationi13174 – 131741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13195 – 131951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13211 – 132111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi13221 ↔ 13241Sequence Analysis
    Glycosylationi13330 – 133301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13351 – 133511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13367 – 133671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi13377 ↔ 13397Sequence Analysis
    Glycosylationi13423 – 134231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13486 – 134861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13507 – 135071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13523 – 135231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi13533 ↔ 13553Sequence Analysis
    Glycosylationi13579 – 135791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13642 – 136421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13663 – 136631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13679 – 136791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi13689 ↔ 13709Sequence Analysis
    Glycosylationi13798 – 137981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13819 – 138191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13835 – 138351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi13845 ↔ 13865Sequence Analysis
    Glycosylationi13954 – 139541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13975 – 139751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13991 – 139911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi14001 ↔ 14021Sequence Analysis
    Glycosylationi14110 – 141101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14131 – 141311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14147 – 141471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi14157 ↔ 14177Sequence Analysis
    Glycosylationi14266 – 142661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14287 – 142871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14303 – 143031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi14313 ↔ 14333Sequence Analysis
    Glycosylationi14359 – 143591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14422 – 144221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14459 – 144591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi14469 ↔ 14489Sequence Analysis
    Glycosylationi14580 – 145801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14601 – 146011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14617 – 146171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi14627 ↔ 14647Sequence Analysis
    Glycosylationi14736 – 147361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14757 – 147571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14773 – 147731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi14783 ↔ 14803Sequence Analysis
    Glycosylationi14825 – 148251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14892 – 148921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14913 – 149131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14929 – 149291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi14939 ↔ 14959Sequence Analysis
    Glycosylationi15048 – 150481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15069 – 150691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi15095 ↔ 15115Sequence Analysis
    Glycosylationi15204 – 152041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15241 – 152411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi15251 ↔ 15271Sequence Analysis
    Glycosylationi15360 – 153601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15381 – 153811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15397 – 153971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi15407 ↔ 15427Sequence Analysis
    Glycosylationi15516 – 155161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15537 – 155371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi15563 ↔ 15583Sequence Analysis
    Glycosylationi15672 – 156721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15693 – 156931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15709 – 157091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi15719 ↔ 15739Sequence Analysis
    Glycosylationi15827 – 158271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15848 – 158481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15864 – 158641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi15874 ↔ 15894Sequence Analysis
    Glycosylationi15947 – 159471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15983 – 159831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16004 – 160041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16020 – 160201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16138 – 161381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16159 – 161591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16175 – 161751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi16185 ↔ 16205Sequence Analysis
    Glycosylationi16258 – 162581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16294 – 162941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16315 – 163151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16331 – 163311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi16341 ↔ 16361Sequence Analysis
    Glycosylationi16450 – 164501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16471 – 164711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16487 – 164871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi16497 ↔ 16517Sequence Analysis
    Glycosylationi16539 – 165391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16606 – 166061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16627 – 166271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16643 – 166431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi16653 ↔ 16673Sequence Analysis
    Glycosylationi16762 – 167621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16783 – 167831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16799 – 167991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi16809 ↔ 16829Sequence Analysis
    Glycosylationi16918 – 169181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16939 – 169391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16955 – 169551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi16965 ↔ 16985Sequence Analysis
    Glycosylationi17074 – 170741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17095 – 170951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17111 – 171111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi17121 ↔ 17141Sequence Analysis
    Glycosylationi17230 – 172301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17251 – 172511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi17277 ↔ 17297Sequence Analysis
    Glycosylationi17386 – 173861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17407 – 174071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17423 – 174231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi17433 ↔ 17453Sequence Analysis
    Glycosylationi17542 – 175421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17563 – 175631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17579 – 175791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi17589 ↔ 17609Sequence Analysis
    Glycosylationi17698 – 176981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17719 – 177191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi17745 ↔ 17765Sequence Analysis
    Glycosylationi17854 – 178541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17875 – 178751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17891 – 178911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18010 – 180101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18031 – 180311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18047 – 180471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi18057 ↔ 18077Sequence Analysis
    Glycosylationi18166 – 181661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18187 – 181871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18203 – 182031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18322 – 183221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18343 – 183431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18359 – 183591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi18369 ↔ 18389Sequence Analysis
    Glycosylationi18478 – 184781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18499 – 184991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18515 – 185151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18634 – 186341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18655 – 186551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi18681 ↔ 18701Sequence Analysis
    Glycosylationi18790 – 187901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18811 – 188111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18827 – 188271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18946 – 189461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18967 – 189671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18983 – 189831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi18993 ↔ 19013Sequence Analysis
    Glycosylationi19039 – 190391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19102 – 191021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19123 – 191231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19139 – 191391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19258 – 192581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19279 – 192791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19295 – 192951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi19305 ↔ 19325Sequence Analysis
    Glycosylationi19414 – 194141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19435 – 194351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19451 – 194511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19570 – 195701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19591 – 195911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19607 – 196071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi19617 ↔ 19637Sequence Analysis
    Glycosylationi19726 – 197261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19747 – 197471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19763 – 197631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19881 – 198811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19902 – 199021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19918 – 199181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi19928 ↔ 19948Sequence Analysis
    Glycosylationi20037 – 200371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20058 – 200581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20074 – 200741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20157 – 201571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20193 – 201931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20214 – 202141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20230 – 202301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20349 – 203491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20370 – 203701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi20396 ↔ 20416Sequence Analysis
    Glycosylationi20505 – 205051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20526 – 205261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi20552 ↔ 20572Sequence Analysis
    Glycosylationi20661 – 206611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20682 – 206821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20698 – 206981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi20708 ↔ 20728Sequence Analysis
    Glycosylationi20817 – 208171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20838 – 208381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi20864 ↔ 20884Sequence Analysis
    Glycosylationi20973 – 209731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20994 – 209941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21010 – 210101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi21020 ↔ 21040Sequence Analysis
    Glycosylationi21129 – 211291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21150 – 211501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21166 – 211661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi21176 ↔ 21196Sequence Analysis
    Glycosylationi21285 – 212851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21306 – 213061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi21332 ↔ 21352Sequence Analysis
    Glycosylationi21378 – 213781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21389 – 213891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21441 – 214411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21461 – 214611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21477 – 214771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21574 – 215741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21595 – 215951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi21621 ↔ 21641Sequence Analysis
    Glycosylationi21725 – 217251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21745 – 217451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi21771 ↔ 21791Sequence Analysis
    Glycosylationi21840 – 218401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21857 – 218571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21899 – 218991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21932 – 219321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21971 – 219711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi22008 – 220081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi22018 ↔ 22038Sequence Analysis
    Glycosylationi22062 – 220621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi22068 – 220681N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.1 Publication
    Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.1 Publication
    May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.1 Publication
    May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8WXI7.
    PaxDbiQ8WXI7.
    PRIDEiQ8WXI7.

    PTM databases

    PhosphoSiteiQ8WXI7.

    Expressioni

    Tissue specificityi

    Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.3 Publications

    Inductioni

    Up-regulated in ovarian cancer cells.1 Publication

    Gene expression databases

    CleanExiHS_MUC16.
    GenevestigatoriQ8WXI7.

    Organism-specific databases

    HPAiCAB055172.

    Interactioni

    Subunit structurei

    Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.

    Protein-protein interaction databases

    BioGridi125094. 3 interactions.
    STRINGi9606.ENSP00000381008.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXI7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2209622096ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini22118 – 2215235CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22097 – 2211721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12070 – 12190121SEA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini12229 – 12339111SEA 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini12386 – 12504119SEA 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini12539 – 12660122SEA 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini12697 – 12815119SEA 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini12853 – 12971119SEA 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini13009 – 13127119SEA 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini13165 – 13283119SEA 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini13315 – 13439125SEA 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini13477 – 13595119SEA 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini13633 – 13751119SEA 11PROSITE-ProRule annotationAdd
    BLAST
    Repeati13767 – 1380135ANK 1Add
    BLAST
    Domaini13789 – 13907119SEA 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini13939 – 14063125SEA 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini14101 – 14219119SEA 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini14251 – 14375125SEA 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini14410 – 14531122SEA 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini14567 – 14689123SEA 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini14723 – 14845123SEA 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini14877 – 15001125SEA 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini15039 – 15157119SEA 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini15195 – 15313119SEA 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini15348 – 15469122SEA 22PROSITE-ProRule annotationAdd
    BLAST
    Domaini15507 – 15625119SEA 23PROSITE-ProRule annotationAdd
    BLAST
    Domaini15664 – 15774111SEA 24PROSITE-ProRule annotationAdd
    BLAST
    Domaini15812 – 15936125SEA 25PROSITE-ProRule annotationAdd
    BLAST
    Domaini16123 – 16247125SEA 26PROSITE-ProRule annotationAdd
    BLAST
    Domaini16279 – 16403125SEA 27PROSITE-ProRule annotationAdd
    BLAST
    Domaini16437 – 16559123SEA 28PROSITE-ProRule annotationAdd
    BLAST
    Domaini16591 – 16715125SEA 29PROSITE-ProRule annotationAdd
    BLAST
    Domaini16750 – 16871122SEA 30PROSITE-ProRule annotationAdd
    BLAST
    Domaini16905 – 17027123SEA 31PROSITE-ProRule annotationAdd
    BLAST
    Domaini17065 – 17183119SEA 32PROSITE-ProRule annotationAdd
    BLAST
    Domaini17221 – 17339119SEA 33PROSITE-ProRule annotationAdd
    BLAST
    Domaini17378 – 17488111SEA 34PROSITE-ProRule annotationAdd
    BLAST
    Domaini17534 – 17644111SEA 35PROSITE-ProRule annotationAdd
    BLAST
    Domaini17689 – 17807119SEA 36PROSITE-ProRule annotationAdd
    BLAST
    Domaini18001 – 18119119SEA 37PROSITE-ProRule annotationAdd
    BLAST
    Domaini18313 – 18431119SEA 38PROSITE-ProRule annotationAdd
    BLAST
    Domaini18625 – 18743119SEA 39PROSITE-ProRule annotationAdd
    BLAST
    Repeati18915 – 1894935ANK 2Add
    BLAST
    Domaini18937 – 19055119SEA 40PROSITE-ProRule annotationAdd
    BLAST
    Domaini19243 – 19367125SEA 41PROSITE-ProRule annotationAdd
    BLAST
    Domaini19555 – 19679125SEA 42PROSITE-ProRule annotationAdd
    BLAST
    Domaini19866 – 19990125SEA 43PROSITE-ProRule annotationAdd
    BLAST
    Domaini20184 – 20302119SEA 44PROSITE-ProRule annotationAdd
    BLAST
    Domaini20340 – 20458119SEA 45PROSITE-ProRule annotationAdd
    BLAST
    Domaini20496 – 20614119SEA 46PROSITE-ProRule annotationAdd
    BLAST
    Domaini20652 – 20770119SEA 47PROSITE-ProRule annotationAdd
    BLAST
    Domaini20804 – 20926123SEA 48PROSITE-ProRule annotationAdd
    BLAST
    Domaini20964 – 21082119SEA 49PROSITE-ProRule annotationAdd
    BLAST
    Domaini21117 – 21238122SEA 50PROSITE-ProRule annotationAdd
    BLAST
    Domaini21273 – 21394122SEA 51PROSITE-ProRule annotationAdd
    BLAST
    Domaini21433 – 21542110SEA 52PROSITE-ProRule annotationAdd
    BLAST
    Domaini21565 – 21683119SEA 53PROSITE-ProRule annotationAdd
    BLAST
    Domaini21717 – 21826110SEA 54PROSITE-ProRule annotationAdd
    BLAST
    Domaini21836 – 21957122SEA 55PROSITE-ProRule annotationAdd
    BLAST
    Domaini21959 – 22080122SEA 56PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 1208512072Thr-richAdd
    BLAST
    Compositional biasi1638 – 30551418Ser-richAdd
    BLAST
    Compositional biasi3961 – 4385425Ser-richAdd
    BLAST
    Compositional biasi7085 – 103953311Ser-richAdd
    BLAST

    Domaini

    Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.

    Sequence similaritiesi

    Contains 2 ANK repeats.Curated
    Contains 56 SEA domains.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    KOiK16145.

    Family and domain databases

    Gene3Di3.30.70.960. 65 hits.
    InterProiIPR028850. MUC16.
    IPR000082. SEA_dom.
    [Graphical view]
    PANTHERiPTHR14672. PTHR14672. 1 hit.
    PfamiPF01390. SEA. 55 hits.
    [Graphical view]
    SMARTiSM00200. SEA. 23 hits.
    [Graphical view]
    SUPFAMiSSF82671. SSF82671. 65 hits.
    PROSITEiPS50024. SEA. 65 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WXI7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKPSGLPGS SSPTRSLMTG SRSTKATPEM DSGLTGATLS PKTSTGAIVV      50
    TEHTLPFTSP DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR 100
    TSPSLSPQVN GTPSRNYPAT SMVSGLSSPR TRTSSTEGNF TKEASTYTLT 150
    VETTSGPVTE KYTVPTETST TEGDSTETPW DTRYIPVKIT SPMKTFADST 200
    ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL SPKGTPNSRG 250
    ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI 300
    FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL 350
    GTPSISTKQT AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS 400
    TSALTTTSPS TTLVSEETNT HHSTSGKETE GTLNTSMTPL ETSAPGEESE 450
    MTATLVPTLG FTTLDSKIRS PSQVSSSHPT RELRTTGSTS GRQSSSTAAH 500
    GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS PSMKTERPPA 550
    STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT 600
    HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS 650
    VSPAVSKTAA GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP 700
    LNTRHPFSSP EPDSAGHTKI STSIPLLSSA SVLEDKVSAT STFSHHKATS 750
    SITTGTPEIS TKTKPSSAVL SSMTLSNAAT SPERVRNATS PLTHPSPSGE 800
    ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL PSVSGVKTTF 850
    SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT 900
    MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ 950
    TNRDTFNDSA APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK 1000
    FTSPATSSME ATSIREPSTT ILTTETTNGP GSMAVASTNI PIGKGYITEG 1050
    RLDTSHLPIG TTASSETSMD FTMAKESVSM SVSPSQSMDA AGSSTPGRTS 1100
    QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS PDPGSARSTW 1150
    LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS 1200
    LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS 1250
    IHLGAHASSE SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS 1300
    SGSSPEMTAP GETNTGSTWD PTTYITTTDP KDTSSAQVST PHSVRTLRTT 1350
    ENHPKTESAT PAAYSGSPKI SSSPNLTSPA TKAWTITDTT EHSTQLHYTK 1400
    LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG EPLVLAPSEQ 1450
    TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS 1500
    KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH 1550
    STQAQDTLSA TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS 1600
    SEATTFWKPS TDTLSREIET GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL 1650
    PIGTSSPAET STNMALERRS STATVSMAGT MGLLVTSAPG RSISQSLGRV 1700
    SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA EGSQMSTSIP 1750
    LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL 1800
    GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG 1850
    VHTSSAGTLA TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTDTE 1900
    KSEVSSSIHP RPETSAPGAE TTLTSTPGNR AISLTLPFSS IPVEEVISTG 1950
    ITSGPDINSA PMTHSPITPP TIVWTSTGTI EQSTQPLHAV SSEKVSVQTQ 2000
    STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS TISRRNAITS 2050
    WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA 2100
    AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI 2150
    TSRSDVSGLT SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP 2200
    WTVSIPLGSH PTTNTETSIP VNSAGPPGLS TVASDVIDTP SDGAESIPTV 2250
    SFSPSPDTEV TTISHFPEKT THSFRTISSL THELTSRVTP IPGDWMSSAM 2300
    STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST VSLDNETTVK 2350
    TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT 2400
    ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL 2450
    PPFTITHPVE TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP 2500
    APGTWASVGS TTDLPAMGFL KTSPAGEAHS LLASTIEPAT AFTPHLSAAV 2550
    VTGSSATSEA SLLTTSESKA IHSSPQTPTT PTSGANWETS ATPESLLVVT 2600
    ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF PTLLPDTPAI 2650
    PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK 2700
    TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST 2750
    LPAGTTGSLV FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG 2800
    IRSGSTHSTG TKTFSSLPLT MNPGEVTAMS EITTNRLTAT QSTAPKGIPV 2850
    KPTSAESGLL TPVSASSSPS KAFASLTTAP PSTWGIPQST LTFEFSEVPS 2900
    LDTKSASLPT PGQSLNTIPD SDASTASSSL SKSPEKNPRA RMMTSTKAIS 2950
    ASSFQSTGFT ETPEGSASPS MAGHEPRVPT SGTGDPRYAS ESMSYPDPSK 3000
    ASSAMTSTSL ASKLTTLFST GQAARSGSSS SPISLSTEKE TSFLSPTAST 3050
    SRKTSLFLGP SMARQPNILV HLQTSALTLS PTSTLNMSQE EPPELTSSQT 3100
    IAEEEGTTAE TQTLTFTPSE TPTSLLPVSS PTEPTARRKS SPETWASSIS 3150
    VPAKTSLVET TDGTLVTTIK MSSQAAQGNS TWPAPAEETG TSPAGTSPGS 3200
    PEVSTTLKIM SSKEPSISPE IRSTVRNSPW KTPETTVPME TTVEPVTLQS 3250
    TALGSGSTSI SHLPTGTTSP TKSPTENMLA TERVSLSPSP PEAWTNLYSG 3300
    TPGGTRQSLA TMSSVSLESP TARSITGTGQ QSSPELVSKT TGMEFSMWHG 3350
    STGGTTGDTH VSLSTSSNIL EDPVTSPNSV SSLTDKSKHK TETWVSTTAI 3400
    PSTVLNNKIM AAEQQTSRSV DEAYSSTSSW SDQTSGSDIT LGASPDVTNT 3450
    LYITSTAQTT SLVSLPSGDQ GITSLTNPSG GKTSSASSVT SPSIGLETLR 3500
    ANVSAVKSDI APTAGHLSQT SSPAEVSILD VTTAPTPGIS TTITTMGTNS 3550
    ISTTTPNPEV GMSTMDSTPA TERRTTSTEH PSTWSSTAAS DSWTVTDMTS 3600
    NLKVARSPGT ISTMHTTSFL ASSTELDSMS TPHGRITVIG TSLVTPSSDA 3650
    SAVKTETSTS ERTLSPSDTT ASTPISTFSR VQRMSISVPD ILSTSWTPSS 3700
    TEAEDVPVSM VSTDHASTKT DPNTPLSTFL FDSLSTLDWD TGRSLSSATA 3750
    TTSAPQGATT PQELTLETMI SPATSQLPFS IGHITSAVTP AAMARSSGVT 3800
    FSRPDPTSKK AEQTSTQLPT TTSAHPGQVP RSAATTLDVI PHTAKTPDAT 3850
    FQRQGQTALT TEARATSDSW NEKEKSTPSA PWITEMMNSV SEDTIKEVTS 3900
    SSSVLKDPEY AGHKLGIWDD FIPKFGKAAH MRELPLLSPP QDKEAIHPST 3950
    NTVETTGWVT SSEHASHSTI PAHSASSKLT SPVVTTSTRE QAIVSMSTTT 4000
    WPESTRARTE PNSFLTIELR DVSPYMDTSS TTQTSIISSP GSTAITKGPR 4050
    TEITSSKRIS SSFLAQSMRS SDSPSEAITR LSNFPAMTES GGMILAMQTS 4100
    PPGATSLSAP TLDTSATASW TGTPLATTQR FTYSEKTTLF SKGPEDTSQP 4150
    SPPSVEETSS SSSLVPIHAT TSPSNILLTS QGHSPSSTPP VTSVFLSETS 4200
    GLGKTTDMSR ISLEPGTSLP PNLSSTAGEA LSTYEASRDT KAIHHSADTA 4250
    VTNMEATSSE YSPIPGHTKP SKATSPLVTS HIMGDITSST SVFGSSETTE 4300
    IETVSSVNQG LQERSTSQVA SSATETSTVI THVSSGDATT HVTKTQATFS 4350
    SGTSISSPHQ FITSTNTFTD VSTNPSTSLI MTESSGVTIT TQTGPTGAAT 4400
    QGPYLLDTST MPYLTETPLA VTPDFMQSEK TTLISKGPKD VTWTSPPSVA 4450
    ETSYPSSLTP FLVTTIPPAT STLQGQHTSS PVSATSVLTS GLVKTTDMLN 4500
    TSMEPVTNSP QNLNNPSNEI LATLAATTDI ETIHPSINKA VTNMGTASSA 4550
    HVLHSTLPVS SEPSTATSPM VPASSMGDAL ASISIPGSET TDIEGEPTSS 4600
    LTAGRKENST LQEMNSTTES NIILSNVSVG AITEATKMEV PSFDATFIPT 4650
    PAQSTKFPDI FSVASSRLSN SPPMTISTHM TTTQTGSSGA TSKIPLALDT 4700
    STLETSAGTP SVVTEGFAHS KITTAMNNDV KDVSQTNPPF QDEASSPSSQ 4750
    APVLVTTLPS SVAFTPQWHS TSSPVSMSSV LTSSLVKTAG KVDTSLETVT 4800
    SSPQSMSNTL DDISVTSAAT TDIETTHPSI NTVVTNVGTT GSAFESHSTV 4850
    SAYPEPSKVT SPNVTTSTME DTTISRSIPK SSKTTRTETE TTSSLTPKLR 4900
    ETSISQEITS STETSTVPYK ELTGATTEVS RTDVTSSSST SFPGPDQSTV 4950
    SLDISTETNT RLSTSPIMTE SAEITITTQT GPHGATSQDT FTMDPSNTTP 5000
    QAGIHSAMTH GFSQLDVTTL MSRIPQDVSW TSPPSVDKTS SPSSFLSSPA 5050
    MTTPSLISST LPEDKLSSPM TSLLTSGLVK ITDILRTRLE PVTSSLPNFS 5100
    STSDKILATS KDSKDTKEIF PSINTEETNV KANNSGHESH SPALADSETP 5150
    KATTQMVITT TVGDPAPSTS MPVHGSSETT NIKREPTYFL TPRLRETSTS 5200
    QESSFPTDTS FLLSKVPTGT ITEVSSTGVN SSSKISTPDH DKSTVPPDTF 5250
    TGEIPRVFTS SIKTKSAEMT ITTQASPPES ASHSTLPLDT STTLSQGGTH 5300
    STVTQGFPYS EVTTLMGMGP GNVSWMTTPP VEETSSVSSL MSSPAMTSPS 5350
    PVSSTSPQSI PSSPLPVTAL PTSVLVTTTD VLGTTSPESV TSSPPNLSSI 5400
    THERPATYKD TAHTEAAMHH STNTAVTNVG TSGSGHKSQS SVLADSETSK 5450
    ATPLMSTTST LGDTSVSTST PNISQTNQIQ TEPTASLSPR LRESSTSEKT 5500
    SSTTETNTAF SYVPTGAITQ ASRTEISSSR TSISDLDRPT IAPDISTGMI 5550
    TRLFTSPIMT KSAEMTVTTQ TTTPGATSQG ILPWDTSTTL FQGGTHSTVS 5600
    QGFPHSEITT LRSRTPGDVS WMTTPPVEET SSGFSLMSPS MTSPSPVSST 5650
    SPESIPSSPL PVTALLTSVL VTTTNVLGTT SPETVTSSPP NLSSPTQERL 5700
    TTYKDTAHTE AMHASMHTNT AVANVGTSIS GHESQSSVPA DSHTSKATSP 5750
    MGITFAMGDT SVSTSTPAFF ETRIQTESTS SLIPGLRDTR TSEEINTVTE 5800
    TSTVLSEVPT TTTTEVSRTE VITSSRTTIS GPDHSKMSPY ISTETITRLS 5850
    TFPFVTGSTE MAITNQTGPI GTISQATLTL DTSSTASWEG THSPVTQRFP 5900
    HSEETTTMSR STKGVSWQSP PSVEETSSPS SPVPLPAITS HSSLYSAVSG 5950
    SSPTSALPVT SLLTSGRRKT IDMLDTHSEL VTSSLPSASS FSGEILTSEA 6000
    STNTETIHFS ENTAETNMGT TNSMHKLHSS VSIHSQPSGH TPPKVTGSMM 6050
    EDAIVSTSTP GSPETKNVDR DSTSPLTPEL KEDSTALVMN STTESNTVFS 6100
    SVSLDAATEV SRAEVTYYDP TFMPASAQST KSPDISPEAS SSHSNSPPLT 6150
    ISTHKTIATQ TGPSGVTSLG QLTLDTSTIA TSAGTPSART QDFVDSETTS 6200
    VMNNDLNDVL KTSPFSAEEA NSLSSQAPLL VTTSPSPVTS TLQEHSTSSL 6250
    VSVTSVPTPT LAKITDMDTN LEPVTRSPQN LRNTLATSEA TTDTHTMHPS 6300
    INTAMANVGT TSSPNEFYFT VSPDSDPYKA TSAVVITSTS GDSIVSTSMP 6350
    RSSAMKKIES ETTFSLIFRL RETSTSQKIG SSSDTSTVFD KAFTAATTEV 6400
    SRTELTSSSR TSIQGTEKPT MSPDTSTRSV TMLSTFAGLT KSEERTIATQ 6450
    TGPHRATSQG TLTWDTSITT SQAGTHSAMT HGFSQLDLST LTSRVPEYIS 6500
    GTSPPSVEKT SSSSSLLSLP AITSPSPVPT TLPESRPSSP VHLTSLPTSG 6550
    LVKTTDMLAS VASLPPNLGS TSHKIPTTSE DIKDTEKMYP STNIAVTNVG 6600
    TTTSEKESYS SVPAYSEPPK VTSPMVTSFN IRDTIVSTSM PGSSEITRIE 6650
    MESTFSVAHG LKGTSTSQDP IVSTEKSAVL HKLTTGATET SRTEVASSRR 6700
    TSIPGPDHST ESPDISTEVI PSLPISLGIT ESSNMTIITR TGPPLGSTSQ 6750
    GTFTLDTPTT SSRAGTHSMA TQEFPHSEMT TVMNKDPEIL SWTIPPSIEK 6800
    TSFSSSLMPS PAMTSPPVSS TLPKTIHTTP SPMTSLLTPS LVMTTDTLGT 6850
    SPEPTTSSPP NLSSTSHVIL TTDEDTTAIE AMHPSTSTAA TNVETTCSGH 6900
    GSQSSVLTDS EKTKATAPMD TTSTMGHTTV STSMSVSSET TKIKRESTYS 6950
    LTPGLRETSI SQNASFSTDT SIVLSEVPTG TTAEVSRTEV TSSGRTSIPG 7000
    PSQSTVLPEI STRTMTRLFA SPTMTESAEM TIPTQTGPSG STSQDTLTLD 7050
    TSTTKSQAKT HSTLTQRFPH SEMTTLMSRG PGDMSWQSSP SLENPSSLPS 7100
    LLSLPATTSP PPISSTLPVT ISSSPLPVTS LLTSSPVTTT DMLHTSPELV 7150
    TSSPPKLSHT SDERLTTGKD TTNTEAVHPS TNTAASNVEI PSFGHESPSS 7200
    ALADSETSKA TSPMFITSTQ EDTTVAISTP HFLETSRIQK ESISSLSPKL 7250
    RETGSSVETS SAIETSAVLS EVSIGATTEI SRTEVTSSSR TSISGSAEST 7300
    MLPEISTTRK IIKFPTSPIL AESSEMTIKT QTSPPGSTSE STFTLDTSTT 7350
    PSLVITHSTM TQRLPHSEIT TLVSRGAGDV PRPSSLPVEE TSPPSSQLSL 7400
    SAMISPSPVS STLPASSHSS SASVTSPLTP GQVKTTEVLD ASAEPETSSP 7450
    PSLSSTSVEI LATSEVTTDT EKIHPFPNTA VTKVGTSSSG HESPSSVLPD 7500
    SETTKATSAM GTISIMGDTS VSTLTPALSN TRKIQSEPAS SLTTRLRETS 7550
    TSEETSLATE ANTVLSKVST GATTEVSRTE AISFSRTSMS GPEQSTMSQD 7600
    ISIGTIPRIS ASSVLTESAK MTITTQTGPS ESTLESTLNL NTATTPSWVE 7650
    THSIVIQGFP HPEMTTSMGR GPGGVSWPSP PFVKETSPPS SPLSLPAVTS 7700
    PHPVSTTFLA HIPPSPLPVT SLLTSGPATT TDILGTSTEP GTSSSSSLST 7750
    TSHERLTTYK DTAHTEAVHP STNTGGTNVA TTSSGYKSQS SVLADSSPMC 7800
    TTSTMGDTSV LTSTPAFLET RRIQTELASS LTPGLRESSG SEGTSSGTKM 7850
    STVLSKVPTG ATTEISKEDV TSIPGPAQST ISPDISTRTV SWFSTSPVMT 7900
    ESAEITMNTH TSPLGATTQG TSTLATSSTT SLTMTHSTIS QGFSHSQMST 7950
    LMRRGPEDVS WMSPPLLEKT RPSFSLMSSP ATTSPSPVSS TLPESISSSP 8000
    LPVTSLLTSG LAKTTDMLHK SSEPVTNSPA NLSSTSVEIL ATSEVTTDTE 8050
    KTHPSSNRTV TDVGTSSSGH ESTSFVLADS QTSKVTSPMV ITSTMEDTSV 8100
    STSTPGFFET SRIQTEPTSS LTLGLRKTSS SEGTSLATEM STVLSGVPTG 8150
    ATAEVSRTEV TSSSRTSISG FAQLTVSPET STETITRLPT SSIMTESAEM 8200
    MIKTQTDPPG STPESTHTVD ISTTPNWVET HSTVTQRFSH SEMTTLVSRS 8250
    PGDMLWPSQS SVEETSSASS LLSLPATTSP SPVSSTLVED FPSASLPVTS 8300
    LLTPGLVITT DRMGISREPG TSSTSNLSST SHERLTTLED TVDTEDMQPS 8350
    THTAVTNVRT SISGHESQSS VLSDSETPKA TSPMGTTYTM GETSVSISTS 8400
    DFFETSRIQI EPTSSLTSGL RETSSSERIS SATEGSTVLS EVPSGATTEV 8450
    SRTEVISSRG TSMSGPDQFT ISPDISTEAI TRLSTSPIMT ESAESAITIE 8500
    TGSPGATSEG TLTLDTSTTT FWSGTHSTAS PGFSHSEMTT LMSRTPGDVP 8550
    WPSLPSVEEA SSVSSSLSSP AMTSTSFFSA LPESISSSPH PVTALLTLGP 8600
    VKTTDMLRTS SEPETSSPPN LSSTSAEILA TSEVTKDREK IHPSSNTPVV 8650
    NVGTVIYKHL SPSSVLADLV TTKPTSPMAT TSTLGNTSVS TSTPAFPETM 8700
    MTQPTSSLTS GLREISTSQE TSSATERSAS LSGMPTGATT KVSRTEALSL 8750
    GRTSTPGPAQ STISPEISTE TITRISTPLT TTGSAEMTIT PKTGHSGASS 8800
    QGTFTLDTSS RASWPGTHSA ATHRSPHSGM TTPMSRGPED VSWPSRPSVE 8850
    KTSPPSSLVS LSAVTSPSPL YSTPSESSHS SPLRVTSLFT PVMMKTTDML 8900
    DTSLEPVTTS PPSMNITSDE SLATSKATME TEAIQLSENT AVTQMGTISA 8950
    RQEFYSSYPG LPEPSKVTSP VVTSSTIKDI VSTTIPASSE ITRIEMESTS 9000
    TLTPTPRETS TSQEIHSATK PSTVPYKALT SATIEDSMTQ VMSSSRGPSP 9050
    DQSTMSQDIS SEVITRLSTS PIKAESTEMT ITTQTGSPGA TSRGTLTLDT 9100
    STTFMSGTHS TASQGFSHSQ MTALMSRTPG DVPWLSHPSV EEASSASFSL 9150
    SSPVMTSSSP VSSTLPDSIH SSSLPVTSLL TSGLVKTTEL LGTSSEPETS 9200
    SPPNLSSTSA EILATTEVTT DTEKLEMTNV VTSGYTHESP SSVLADSVTT 9250
    KATSSMGITY PTGDTNVLTS TPAFSDTSRI QTKSKLSLTP GLMETSISEE 9300
    TSSATEKSTV LSSVPTGATT EVSRTEAISS SRTSIPGPAQ STMSSDTSME 9350
    TITRISTPLT RKESTDMAIT PKTGPSGATS QGTFTLDSSS TASWPGTHSA 9400
    TTQRFPQSVV TTPMSRGPED VSWPSPLSVE KNSPPSSLVS SSSVTSPSPL 9450
    YSTPSGSSHS SPVPVTSLFT SIMMKATDML DASLEPETTS APNMNITSDE 9500
    SLATSKATTE TEAIHVFENT AASHVETTSA TEELYSSSPG FSEPTKVISP 9550
    VVTSSSIRDN MVSTTMPGSS GITRIEIESM SSLTPGLRET RTSQDITSST 9600
    ETSTVLYKMS SGATPEVSRT EVMPSSRTSI PGPAQSTMSL DISDEVVTRL 9650
    STSPIMTESA EITITTQTGY SLATSQVTLP LGTSMTFLSG THSTMSQGLS 9700
    HSEMTNLMSR GPESLSWTSP RFVETTRSSS SLTSLPLTTS LSPVSSTLLD 9750
    SSPSSPLPVT SLILPGLVKT TEVLDTSSEP KTSSSPNLSS TSVEIPATSE 9800
    IMTDTEKIHP SSNTAVAKVR TSSSVHESHS SVLADSETTI TIPSMGITSA 9850
    VDDTTVFTSN PAFSETRRIP TEPTFSLTPG FRETSTSEET TSITETSAVL 9900
    YGVPTSATTE VSMTEIMSSN RTHIPDSDQS TMSPDIITEV ITRLSSSSMM 9950
    SESTQMTITT QKSSPGATAQ STLTLATTTA PLARTHSTVP PRFLHSEMTT 10000
    LMSRSPENPS WKSSPFVEKT SSSSSLLSLP VTTSPSVSST LPQSIPSSSF 10050
    SVTSLLTPGM VKTTDTSTEP GTSLSPNLSG TSVEILAASE VTTDTEKIHP 10100
    SSSMAVTNVG TTSSGHELYS SVSIHSEPSK ATYPVGTPSS MAETSISTSM 10150
    PANFETTGFE AEPFSHLTSG FRKTNMSLDT SSVTPTNTPS SPGSTHLLQS 10200
    SKTDFTSSAK TSSPDWPPAS QYTEIPVDII TPFNASPSIT ESTGITSFPE 10250
    SRFTMSVTES THHLSTDLLP SAETISTGTV MPSLSEAMTS FATTGVPRAI 10300
    SGSGSPFSRT ESGPGDATLS TIAESLPSST PVPFSSSTFT TTDSSTIPAL 10350
    HEITSSSATP YRVDTSLGTE SSTTEGRLVM VSTLDTSSQP GRTSSTPILD 10400
    TRMTESVELG TVTSAYQVPS LSTRLTRTDG IMEHITKIPN EAAHRGTIRP 10450
    VKGPQTSTSP ASPKGLHTGG TKRMETTTTA LKTTTTALKT TSRATLTTSV 10500
    YTPTLGTLTP LNASRQMAST ILTEMMITTP YVFPDVPETT SSLATSLGAE 10550
    TSTALPRTTP SVLNRESETT ASLVSRSGAE RSPVIQTLDV SSSEPDTTAS 10600
    WVIHPAETIP TVSKTTPNFF HSELDTVSST ATSHGADVSS AIPTNISPSE 10650
    LDALTPLVTI SGTDTSTTFP TLTKSPHETE TRTTWLTHPA ETSSTIPRTI 10700
    PNFSHHESDA TPSIATSPGA ETSSAIPIMT VSPGAEDLVT SQVTSSGTDR 10750
    NMTIPTLTLS PGEPKTIASL VTHPEAQTSS AIPTSTISPA VSRLVTSMVT 10800
    SLAAKTSTTN RALTNSPGEP ATTVSLVTHP AQTSPTVPWT TSIFFHSKSD 10850
    TTPSMTTSHG AESSSAVPTP TVSTEVPGVV TPLVTSSRAV ISTTIPILTL 10900
    SPGEPETTPS MATSHGEEAS SAIPTPTVSP GVPGVVTSLV TSSRAVTSTT 10950
    IPILTFSLGE PETTPSMATS HGTEAGSAVP TVLPEVPGMV TSLVASSRAV 11000
    TSTTLPTLTL SPGEPETTPS MATSHGAEAS STVPTVSPEV PGVVTSLVTS 11050
    SSGVNSTSIP TLILSPGELE TTPSMATSHG AEASSAVPTP TVSPGVSGVV 11100
    TPLVTSSRAV TSTTIPILTL SSSEPETTPS MATSHGVEAS SAVLTVSPEV 11150
    PGMVTSLVTS SRAVTSTTIP TLTISSDEPE TTTSLVTHSE AKMISAIPTL 11200
    AVSPTVQGLV TSLVTSSGSE TSAFSNLTVA SSQPETIDSW VAHPGTEASS 11250
    VVPTLTVSTG EPFTNISLVT HPAESSSTLP RTTSRFSHSE LDTMPSTVTS 11300
    PEAESSSAIS TTISPGIPGV LTSLVTSSGR DISATFPTVP ESPHESEATA 11350
    SWVTHPAVTS TTVPRTTPNY SHSEPDTTPS IATSPGAEAT SDFPTITVSP 11400
    DVPDMVTSQV TSSGTDTSIT IPTLTLSSGE PETTTSFITY SETHTSSAIP 11450
    TLPVSPGASK MLTSLVISSG TDSTTTFPTL TETPYEPETT AIQLIHPAET 11500
    NTMVPKTTPK FSHSKSDTTL PVAITSPGPE ASSAVSTTTI SPDMSDLVTS 11550
    LVPSSGTDTS TTFPTLSETP YEPETTVTWL THPAETSTTV SGTIPNFSHR 11600
    GSDTAPSMVT SPGVDTRSGV PTTTIPPSIP GVVTSQVTSS ATDTSTAIPT 11650
    LTPSPGEPET TASSATHPGT QTGFTVPIRT VPSSEPDTMA SWVTHPPQTS 11700
    TPVSRTTSSF SHSSPDATPV MATSPRTEAS SAVLTTISPG APEMVTSQIT 11750
    SSGAATSTTV PTLTHSPGMP ETTALLSTHP RTGTSKTFPA STVFPQVSET 11800
    TASLTIRPGA ETSTALPTQT TSSLFTLLVT GTSRVDLSPT ASPGVSAKTA 11850
    PLSTHPGTET STMIPTSTLS LGLLETTGLL ATSSSAETST STLTLTVSPA 11900
    VSGLSSASIT TDKPQTVTSW NTETSPSVTS VGPPEFSRTV TGTTMTLIPS 11950
    EMPTPPKTSH GEGVSPTTIL RTTMVEATNL ATTGSSPTVA KTTTTFNTLA 12000
    GSLFTPLTTP GMSTLASESV TSRTSYNHRS WISTTSSYNR RYWTPATSTP 12050
    VTSTFSPGIS TSSIPSSTAA TVPFMVPFTL NFTITNLQYE EDMRHPGSRK 12100
    FNATERELQG LLKPLFRNSS LEYLYSGCRL ASLRPEKDSS AMAVDAICTH 12150
    RPDPEDLGLD RERLYWELSN LTNGIQELGP YTLDRNSLYV NGFTHRSSMP 12200
    TTSTPGTSTV DVGTSGTPSS SPSPTAAGPL LMPFTLNFTI TNLQYEEDMR 12250
    RTGSRKFNTM ESVLQGLLKP LFKNTSVGPL YSGCRLTLLR PEKDGAATGV 12300
    DAICTHRLDP KSPGLNREQL YWELSKLTND IEELGPYTLD RNSLYVNGFT 12350
    HQSSVSTTST PGTSTVDLRT SGTPSSLSSP TIMAAGPLLV PFTLNFTITN 12400
    LQYGEDMGHP GSRKFNTTER VLQGLLGPIF KNTSVGPLYS GCRLTSLRSE 12450
    KDGAATGVDA ICIHHLDPKS PGLNRERLYW ELSQLTNGIK ELGPYTLDRN 12500
    SLYVNGFTHR TSVPTTSTPG TSTVDLGTSG TPFSLPSPAT AGPLLVLFTL 12550
    NFTITNLKYE EDMHRPGSRK FNTTERVLQT LLGPMFKNTS VGLLYSGCRL 12600
    TLLRSEKDGA ATGVDAICTH RLDPKSPGLD REQLYWELSQ LTNGIKELGP 12650
    YTLDRNSLYV NGFTHWIPVP TSSTPGTSTV DLGSGTPSSL PSPTAAGPLL 12700
    VPFTLNFTIT NLQYEEDMHH PGSRKFNTTE RVLQGLLGPM FKNTSVGLLY 12750
    SGCRLTLLRS EKDGAATGVD AICTHRLDPK SPGVDREQLY WELSQLTNGI 12800
    KELGPYTLDR NSLYVNGFTH QTSAPNTSTP GTSTVDLGTS GTPSSLPSPT 12850
    SAGPLLVPFT LNFTITNLQY EEDMRHPGSR KFNTTERVLQ GLLKPLFKST 12900
    SVGPLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGV DREQLYWELS 12950
    QLTNGIKELG PYTLDRNSLY VNGFTHQTSA PNTSTPGTST VDLGTSGTPS 13000
    SLPSPTSAGP LLVPFTLNFT ITNLQYEEDM HHPGSRKFNT TERVLQGLLG 13050
    PMFKNTSVGL LYSGCRLTLL RPEKNGAATG MDAICSHRLD PKSPGLNREQ 13100
    LYWELSQLTH GIKELGPYTL DRNSLYVNGF THRSSVAPTS TPGTSTVDLG 13150
    TSGTPSSLPS PTTAVPLLVP FTLNFTITNL QYGEDMRHPG SRKFNTTERV 13200
    LQGLLGPLFK NSSVGPLYSG CRLISLRSEK DGAATGVDAI CTHHLNPQSP 13250
    GLDREQLYWQ LSQMTNGIKE LGPYTLDRNS LYVNGFTHRS SGLTTSTPWT 13300
    STVDLGTSGT PSPVPSPTTA GPLLVPFTLN FTITNLQYEE DMHRPGSRKF 13350
    NTTERVLQGL LSPIFKNSSV GPLYSGCRLT SLRPEKDGAA TGMDAVCLYH 13400
    PNPKRPGLDR EQLYWELSQL THNITELGPY SLDRDSLYVN GFTHQNSVPT 13450
    TSTPGTSTVY WATTGTPSSF PGHTEPGPLL IPFTFNFTIT NLHYEENMQH 13500
    PGSRKFNTTE RVLQGLLKPL FKNTSVGPLY SGCRLTSLRP EKDGAATGMD 13550
    AVCLYHPNPK RPGLDREQLY WELSQLTHNI TELGPYSLDR DSLYVNGFTH 13600
    QNSVPTTSTP GTSTVYWATT GTPSSFPGHT EPGPLLIPFT FNFTITNLHY 13650
    EENMQHPGSR KFNTTERVLQ GLLKPLFKNT SVGPLYSGCR LTLLRPEKHE 13700
    AATGVDTICT HRVDPIGPGL DRERLYWELS QLTNSITELG PYTLDRDSLY 13750
    VNGFNPRSSV PTTSTPGTST VHLATSGTPS SLPGHTAPVP LLIPFTLNFT 13800
    ITNLHYEENM QHPGSRKFNT TERVLQGLLK PLFKNTSVGP LYSGCRLTLL 13850
    RPEKHEAATG VDTICTHRVD PIGPGLXXEX LYWELSXLTX XIXELGPYTL 13900
    DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX XTSAGPLLVP 13950
    FTLNFTITNL QYEEDMHHPG SRKFNTTERV LQGLLGPMFK NTSVGLLYSG 14000
    CRLTLLRPEK NGAATGMDAI CSHRLDPKSP GLDREQLYWE LSQLTHGIKE 14050
    LGPYTLDRNS LYVNGFTHRS SVAPTSTPGT STVDLGTSGT PSSLPSPTTA 14100
    VPLLVPFTLN FTITNLQYGE DMRHPGSRKF NTTERVLQGL LGPLFKNSSV 14150
    GPLYSGCRLI SLRSEKDGAA TGVDAICTHH LNPQSPGLDR EQLYWQLSQM 14200
    TNGIKELGPY TLDRNSLYVN GFTHRSSGLT TSTPWTSTVD LGTSGTPSPV 14250
    PSPTTAGPLL VPFTLNFTIT NLQYEEDMHR PGSRKFNATE RVLQGLLSPI 14300
    FKNSSVGPLY SGCRLTSLRP EKDGAATGMD AVCLYHPNPK RPGLDREQLY 14350
    WELSQLTHNI TELGPYSLDR DSLYVNGFTH QSSMTTTRTP DTSTMHLATS 14400
    RTPASLSGPT TASPLLVLFT INCTITNLQY EEDMRRTGSR KFNTMESVLQ 14450
    GLLKPLFKNT SVGPLYSGCR LTLLRPKKDG AATGVDAICT HRLDPKSPGL 14500
    NREQLYWELS KLTNDIEELG PYTLDRNSLY VNGFTHQSSV STTSTPGTST 14550
    VDLRTSGTPS SLSSPTIMXX XPLLXPFTXN XTITNLXXXX XMXXPGSRKF 14600
    NTTERVLQGL LRPLFKNTSV SSLYSGCRLT LLRPEKDGAA TRVDAACTYR 14650
    PDPKSPGLDR EQLYWELSQL THSITELGPY TLDRVSLYVN GFNPRSSVPT 14700
    TSTPGTSTVH LATSGTPSSL PGHTXXXPLL XPFTXNXTIT NLXXXXXMXX 14750
    PGSRKFNTTE RVLQGLLKPL FRNSSLEYLY SGCRLASLRP EKDSSAMAVD 14800
    AICTHRPDPE DLGLDRERLY WELSNLTNGI QELGPYTLDR NSLYVNGFTH 14850
    RSSGLTTSTP WTSTVDLGTS GTPSPVPSPT TAGPLLVPFT LNFTITNLQY 14900
    EEDMHRPGSR RFNTTERVLQ GLLTPLFKNT SVGPLYSGCR LTLLRPEKQE 14950
    AATGVDTICT HRVDPIGPGL DRERLYWELS QLTNSITELG PYTLDRDSLY 15000
    VNGFNPWSSV PTTSTPGTST VHLATSGTPS SLPGHTAPVP LLIPFTLNFT 15050
    ITDLHYEENM QHPGSRKFNT TERVLQGLLK PLFKSTSVGP LYSGCRLTLL 15100
    RPEKHGAATG VDAICTLRLD PTGPGLDRER LYWELSQLTN SVTELGPYTL 15150
    DRDSLYVNGF THRSSVPTTS IPGTSAVHLE TSGTPASLPG HTAPGPLLVP 15200
    FTLNFTITNL QYEEDMRHPG SRKFSTTERV LQGLLKPLFK NTSVSSLYSG 15250
    CRLTLLRPEK DGAATRVDAV CTHRPDPKSP GLDRERLYWK LSQLTHGITE 15300
    LGPYTLDRHS LYVNGFTHQS SMTTTRTPDT STMHLATSRT PASLSGPTTA 15350
    SPLLVLFTIN FTITNLRYEE NMHHPGSRKF NTTERVLQGL LRPVFKNTSV 15400
    GPLYSGCRLT TLRPKKDGAA TKVDAICTYR PDPKSPGLDR EQLYWELSQL 15450
    THSITELGPY TQDRDSLYVN GFTHRSSVPT TSIPGTSAVH LETSGTPASL 15500
    PGHTAPGPLL VPFTLNFTIT NLQYEEDMRH PGSRKFNTTE RVLQGLLKPL 15550
    FKSTSVGPLY SGCRLTLLRP EKRGAATGVD TICTHRLDPL NPGLDREQLY 15600
    WELSKLTRGI IELGPYLLDR GSLYVNGFTH RTSVPTTSTP GTSTVDLGTS 15650
    GTPFSLPSPA XXXPLLXPFT XNXTITNLXX XXXMXXPGSR KFNTTERVLQ 15700
    TLLGPMFKNT SVGLLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGV 15750
    DREQLYWELS QLTNGIKELG PYTLDRNSLY VNGFTHWIPV PTSSTPGTST 15800
    VDLGSGTPSS LPSPTTAGPL LVPFTLNFTI TNLKYEEDMH CPGSRKFNTT 15850
    ERVLQSLLGP MFKNTSVGPL YSGCRLTLLR SEKDGAATGV DAICTHRLDP 15900
    KSPGVDREQL YWELSQLTNG IKELGPYTLD RNSLYVNGFT HQTSAPNTST 15950
    PGTSTVDLGT SGTPSSLPSP TXXXPLLXPF TXNXTITNLX XXXXMXXPGS 16000
    RKFNTTEXVL QGLLXPXFKN XSVGXLYSGC RLTXLRXEKX GAATGXDAIC 16050
    XHXXXPKXPG LXXEXLYWEL SXLTXXIXEL GPYTLDRXSL YVNGFTHWIP 16100
    VPTSSTPGTS TVDLGSGTPS SLPSPTTAGP LLVPFTLNFT ITNLKYEEDM 16150
    HCPGSRKFNT TERVLQSLLG PMFKNTSVGP LYSGCRLTSL RSEKDGAATG 16200
    VDAICTHRVD PKSPGVDREQ LYWELSQLTN GIKELGPYTL DRNSLYVNGF 16250
    THQTSAPNTS TPGTSTVXXG TSGTPSSXPX XTSAGPLLVP FTLNFTITNL 16300
    QYEEDMHHPG SRKFNTTERV LQGLLGPMFK NTSVGLLYSG CRLTLLRPEK 16350
    NGATTGMDAI CTHRLDPKSP GLXXEXLYWE LSXLTXXIXE LGPYTLDRXS 16400
    LYVNGFTHXX SXPTTSTPGT STVXXGTSGT PSSXPXXTXX XPLLXPFTXN 16450
    XTITNLXXXX XMXXPGSRKF NTTERVLQGL LKPLFRNSSL EYLYSGCRLA 16500
    SLRPEKDSSA MAVDAICTHR PDPEDLGLDR ERLYWELSNL TNGIQELGPY 16550
    TLDRNSLYVN GFTHRSSMPT TSTPGTSTVD VGTSGTPSSS PSPTTAGPLL 16600
    IPFTLNFTIT NLQYGEDMGH PGSRKFNTTE RVLQGLLGPI FKNTSVGPLY 16650
    SGCRLTSLRS EKDGAATGVD AICIHHLDPK SPGLNRERLY WELSQLTNGI 16700
    KELGPYTLDR NSLYVNGFTH RTSVPTTSTP GTSTVDLGTS GTPFSLPSPA 16750
    TAGPLLVLFT LNFTITNLKY EEDMHRPGSR KFNTTERVLQ TLLGPMFKNT 16800
    SVGLLYSGCR LTLLRSEKDG AATGVDAICT HRLDPKSPGL XXEXLYWELS 16850
    XLTXXIXELG PYTLDRXSLY VNGFTHXXSX PTTSTPGTST VXXGTSGTPS 16900
    SXPXXTXXXP LLXPFTXNXT ITNLXXXXXM XXPGSRKFNT TERVLQGLLR 16950
    PVFKNTSVGP LYSGCRLTLL RPKKDGAATK VDAICTYRPD PKSPGLDREQ 17000
    LYWELSQLTH SITELGPYTQ DRDSLYVNGF THRSSVPTTS IPGTSAVHLE 17050
    TTGTPSSFPG HTEPGPLLIP FTFNFTITNL RYEENMQHPG SRKFNTTERV 17100
    LQGLLTPLFK NTSVGPLYSG CRLTLLRPEK QEAATGVDTI CTHRVDPIGP 17150
    GLDRERLYWE LSQLTNSITE LGPYTLDRDS LYVDGFNPWS SVPTTSTPGT 17200
    STVHLATSGT PSPLPGHTAP VPLLIPFTLN FTITDLHYEE NMQHPGSRKF 17250
    NTTERVLQGL LKPLFKSTSV GPLYSGCRLT LLRPEKHGAA TGVDAICTLR 17300
    LDPTGPGLDR ERLYWELSQL TNSITELGPY TLDRDSLYVN GFNPWSSVPT 17350
    TSTPGTSTVH LATSGTPSSL PGHTTAGPLL VPFTLNFTIT NLKYEEDMHC 17400
    PGSRKFNTTE RVLQSLHGPM FKNTSVGPLY SGCRLTLLRS EKDGAATGVD 17450
    AICTHRLDPK SPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH 17500
    XXSXPTTSTP GTSTVXXGTS GTPSSXPXXT XXXPLLXPFT XNXTITNLXX 17550
    XXXMXXPGSR KFNTTEXVLQ GLLXPXFKNX SVGXLYSGCR LTXLRXEKXG 17600
    AATGXDAICX HXXXPKXPGL XXEXLYWELS XLTNSITELG PYTLDRDSLY 17650
    VNGFTHRSSM PTTSIPGTSA VHLETSGTPA SLPGHTAPGP LLVPFTLNFT 17700
    ITNLQYEEDM RHPGSRKFNT TERVLQGLLK PLFKSTSVGP LYSGCRLTLL 17750
    RPEKRGAATG VDTICTHRLD PLNPGLXXEX LYWELSXLTX XIXELGPYTL 17800
    DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX XTXXXPLLXP 17850
    FTXNXTITNL XXXXXMXXPG SRKFNTTEXV LQGLLXPXFK NXSVGXLYSG 17900
    CRLTXLRXEK XGAATGXDAI CXHXXXPKXP GLXXEXLYWE LSXLTXXIXE 17950
    LGPYTLDRXS LYVNGFHPRS SVPTTSTPGT STVHLATSGT PSSLPGHTAP 18000
    VPLLIPFTLN FTITNLHYEE NMQHPGSRKF NTTERVLQGL LGPMFKNTSV 18050
    GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLXX EXLYWELSXL 18100
    TXXIXELGPY TLDRXSLYVN GFTHXXSXPT TSTPGTSTVX XGTSGTPSSX 18150
    PXXTXXXPLL XPFTXNXTIT NLXXXXXMXX PGSRKFNTTE XVLQGLLXPX 18200
    FKNXSVGXLY SGCRLTXLRX EKXGAATGXD AICXHXXXPK XPGLXXEXLY 18250
    WELSXLTXXI XELGPYTLDR XSLYVNGFTH QNSVPTTSTP GTSTVYWATT 18300
    GTPSSFPGHT EPGPLLIPFT FNFTITNLHY EENMQHPGSR KFNTTERVLQ 18350
    GLLTPLFKNT SVGPLYSGCR LTLLRPEKQE AATGVDTICT HRVDPIGPGL 18400
    XXEXLYWELS XLTXXIXELG PYTLDRXSLY VNGFTHXXSX PTTSTPGTST 18450
    VXXGTSGTPS SXPXXTXXXP LLXPFTXNXT ITNLXXXXXM XXPGSRKFNT 18500
    TEXVLQGLLX PXFKNXSVGX LYSGCRLTXL RXEKXGAATG XDAICXHXXX 18550
    PKXPGLXXEX LYWELSXLTX XIXELGPYTL DRXSLYVNGF THRSSVPTTS 18600
    SPGTSTVHLA TSGTPSSLPG HTAPVPLLIP FTLNFTITNL HYEENMQHPG 18650
    SRKFNTTERV LQGLLKPLFK STSVGPLYSG CRLTLLRPEK HGAATGVDAI 18700
    CTLRLDPTGP GLXXEXLYWE LSXLTXXIXE LGPYTLDRXS LYVNGFTHXX 18750
    SXPTTSTPGT STVXXGTSGT PSSXPXXTXX XPLLXPFTXN XTITNLXXXX 18800
    XMXXPGSRKF NTTEXVLQGL LXPXFKNXSV GXLYSGCRLT XLRXEKXGAA 18850
    TGXDAICXHX XXPKXPGLXX EXLYWELSXL TXXIXELGPY TLDRXSLYVN 18900
    GFTHRTSVPT TSTPGTSTVH LATSGTPSSL PGHTAPVPLL IPFTLNFTIT 18950
    NLQYEEDMHR PGSRKFNTTE RVLQGLLSPI FKNSSVGPLY SGCRLTSLRP 19000
    EKDGAATGMD AVCLYHPNPK RPGLDREQLY CELSQLTHNI TELGPYSLDR 19050
    DSLYVNGFTH QNSVPTTSTP GTSTVYWATT GTPSSFPGHT XXXPLLXPFT 19100
    XNXTITNLXX XXXMXXPGSR KFNTTEXVLQ GLLXPXFKNX SVGXLYSGCR 19150
    LTXLRXEKXG AATGXDAICX HXXXPKXPGL XXEXLYWELS XLTXXIXELG 19200
    PYTLDRXSLY VNGFTHWSSG LTTSTPWTST VDLGTSGTPS PVPSPTTAGP 19250
    LLVPFTLNFT ITNLQYEEDM HRPGSRKFNA TERVLQGLLS PIFKNTSVGP 19300
    LYSGCRLTLL RPEKQEAATG VDTICTHRVD PIGPGLXXEX LYWELSXLTX 19350
    XIXELGPYTL DRXSLYVNGF THXXSXPTTS TPGTSTVXXG TSGTPSSXPX 19400
    XTXXXPLLXP FTXNXTITNL XXXXXMXXPG SRKFNTTEXV LQGLLXPXFK 19450
    NXSVGXLYSG CRLTXLRXEK XGAATGXDAI CXHXXXPKXP GLXXEXLYWE 19500
    LSXLTXXIXE LGPYTLDRXS LYVNGFTHRS FGLTTSTPWT STVDLGTSGT 19550
    PSPVPSPTTA GPLLVPFTLN FTITNLQYEE DMHRPGSRKF NTTERVLQGL 19600
    LTPLFRNTSV SSLYSGCRLT LLRPEKDGAA TRVDAVCTHR PDPKSPGLXX 19650
    EXLYWELSXL TXXIXELGPY TLDRXSLYVN GFTHXXSXPT TSTPGTSTVX 19700
    XGTSGTPSSX PXXTXXXPLL XPFTXNXTIT NLXXXXXMXX PGSRKFNTTE 19750
    XVLQGLLXPX FKNXSVGXLY SGCRLTXLRX EKXGAATGXD AICXHXXXPK 19800
    XPGLXXEXLY WELSXLTXXI XELGPYTLDR XSLYVNGFTH WIPVPTSSTP 19850
    GTSTVDLGSG TPSSLPSPTT AGPLLVPFTL NFTITNLQYG EDMGHPGSRK 19900
    FNTTERVLQG LLGPIFKNTS VGPLYSGCRL TSLRSEKDGA ATGVDAICIH 19950
    HLDPKSPGLX XEXLYWELSX LTXXIXELGP YTLDRXSLYV NGFTHXXSXP 20000
    TTSTPGTSTV XXGTSGTPSS XPXXTXXXPL LXPFTXNXTI TNLXXXXXMX 20050
    XPGSRKFNTT EXVLQGLLXP XFKNXSVGXL YSGCRLTXLR XEKXGAATGX 20100
    DAICXHXXXP KXPGLXXEXL YWELSXLTXX IXELGPYTLD RXSLYVNGFT 20150
    HQTFAPNTST PGTSTVDLGT SGTPSSLPSP TSAGPLLVPF TLNFTITNLQ 20200
    YEEDMHHPGS RKFNTTERVL QGLLGPMFKN TSVGLLYSGC RLTLLRPEKN 20250
    GAATRVDAVC THRPDPKSPG LXXEXLYWEL SXLTXXIXEL GPYTLDRXSL 20300
    YVNGFTHXXS XPTTSTPGTS TVXXGTSGTP SSXPXXTAPV PLLIPFTLNF 20350
    TITNLHYEEN MQHPGSRKFN TTERVLQGLL KPLFKSTSVG PLYSGCRLTL 20400
    LRPEKHGAAT GVDAICTLRL DPTGPGLDRE RLYWELSQLT NSVTELGPYT 20450
    LDRDSLYVNG FTQRSSVPTT SIPGTSAVHL ETSGTPASLP GHTAPGPLLV 20500
    PFTLNFTITN LQYEVDMRHP GSRKFNTTER VLQGLLKPLF KSTSVGPLYS 20550
    GCRLTLLRPE KRGAATGVDT ICTHRLDPLN PGLDREQLYW ELSKLTRGII 20600
    ELGPYLLDRG SLYVNGFTHR NFVPITSTPG TSTVHLGTSE TPSSLPRPIV 20650
    PGPLLVPFTL NFTITNLQYE EAMRHPGSRK FNTTERVLQG LLRPLFKNTS 20700
    IGPLYSSCRL TLLRPEKDKA ATRVDAICTH HPDPQSPGLN REQLYWELSQ 20750
    LTHGITELGP YTLDRDSLYV DGFTHWSPIP TTSTPGTSIV NLGTSGIPPS 20800
    LPETTXXXPL LXPFTXNXTI TNLXXXXXMX XPGSRKFNTT ERVLQGLLKP 20850
    LFKSTSVGPL YSGCRLTLLR PEKDGVATRV DAICTHRPDP KIPGLDRQQL 20900
    YWELSQLTHS ITELGPYTLD RDSLYVNGFT QRSSVPTTST PGTFTVQPET 20950
    SETPSSLPGP TATGPVLLPF TLNFTITNLQ YEEDMHRPGS RKFNTTERVL 21000
    QGLLMPLFKN TSVSSLYSGC RLTLLRPEKD GAATRVDAVC THRPDPKSPG 21050
    LDRERLYWKL SQLTHGITEL GPYTLDRHSL YVNGFTHQSS MTTTRTPDTS 21100
    TMHLATSRTP ASLSGPTTAS PLLVLFTINF TITNLRYEEN MHHPGSRKFN 21150
    TTERVLQGLL RPVFKNTSVG PLYSGCRLTL LRPKKDGAAT KVDAICTYRP 21200
    DPKSPGLDRE QLYWELSQLT HSITELGPYT LDRDSLYVNG FTQRSSVPTT 21250
    SIPGTPTVDL GTSGTPVSKP GPSAASPLLV LFTLNFTITN LRYEENMQHP 21300
    GSRKFNTTER VLQGLLRSLF KSTSVGPLYS GCRLTLLRPE KDGTATGVDA 21350
    ICTHHPDPKS PRLDREQLYW ELSQLTHNIT ELGHYALDND SLFVNGFTHR 21400
    SSVSTTSTPG TPTVYLGASK TPASIFGPSA ASHLLILFTL NFTITNLRYE 21450
    ENMWPGSRKF NTTERVLQGL LRPLFKNTSV GPLYSGSRLT LLRPEKDGEA 21500
    TGVDAICTHR PDPTGPGLDR EQLYLELSQL THSITELGPY TLDRDSLYVN 21550
    GFTHRSSVPT TSTGVVSEEP FTLNFTINNL RYMADMGQPG SLKFNITDNV 21600
    MKHLLSPLFQ RSSLGARYTG CRVIALRSVK NGAETRVDLL CTYLQPLSGP 21650
    GLPIKQVFHE LSQQTHGITR LGPYSLDKDS LYLNGYNEPG LDEPPTTPKP 21700
    ATTFLPPLSE ATTAMGYHLK TLTLNFTISN LQYSPDMGKG SATFNSTEGV 21750
    LQHLLRPLFQ KSSMGPFYLG CQLISLRPEK DGAATGVDTT CTYHPDPVGP 21800
    GLDIQQLYWE LSQLTHGVTQ LGFYVLDRDS LFINGYAPQN LSIRGEYQIN 21850
    FHIVNWNLSN PDPTSSEYIT LLRDIQDKVT TLYKGSQLHD TFRFCLVTNL 21900
    TMDSVLVTVK ALFSSNLDPS LVEQVFLDKT LNASFHWLGS TYQLVDIHVT 21950
    EMESSVYQPT SSSSTQHFYL NFTITNLPYS QDKAQPGTTN YQRNKRNIED 22000
    ALNQLFRNSS IKSYFSDCQV STFRSVPNRH HTGVDSLCNF SPLARRVDRV 22050
    AIYEEFLRMT RNGTQLQNFT LDRSSVLVDG YSPNRNEPLT GNSDLPFWAV 22100
    ILIGLAGLLG LITCLICGVL VTTRRRKKEG EYNVQQQCPG YYQSHLDLED 22150
    LQ 22152
    Length:22,152
    Mass (Da):2,353,428
    Last modified:March 1, 2003 - v2
    Checksum:iB3E7BDF19997A440
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8346 – 83461D → A in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti8580 – 85801A → T in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti9061 – 90611S → T in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti9074 – 90741A → T in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti9131 – 91311D → E in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti9407 – 94071Q → R in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti9504 – 95041T → A in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti9610 – 96101S → P in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti9852 – 98521D → E in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti9901 – 99011Y → F in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti10171 – 101711F → L in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti10396 – 103961T → S in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti10515 – 105151R → M in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti10522 – 105221L → P in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti10563 – 105631L → F in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti10830 – 108301P → S in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti11156 – 111561S → F in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti11201 – 112011A → G in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti11457 – 114571G → D in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti11506 – 115061K → R in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti11577 – 115771V → A in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti11783 – 117831G → E in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti12142 – 121421M → T in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti12226 – 122261A → T in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti12582 – 125821L → V in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti12629 – 126291L → V in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti12695 – 126951A → SAT in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti12713 – 127131Q → K in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti12720 – 127201H → C in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti12735 – 127351G → S in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti12744 – 12899156Missing in AAK74120. (PubMed:11369781)CuratedAdd
    BLAST
    Sequence conflicti13352 – 133521T → A in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti13519 – 149241406Missing in AAK74120. (PubMed:11369781)CuratedAdd
    BLAST
    Sequence conflicti15053 – 150531D → N in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti15215 – 205155301Missing in AAK74120. (PubMed:11369781)CuratedAdd
    BLAST
    Sequence conflicti20515 – 205151V → E in BAC87568. (PubMed:14702039)Curated
    Sequence conflicti20760 – 21071312Missing in BAC87568. (PubMed:14702039)CuratedAdd
    BLAST
    Sequence conflicti20839 – 208391T → I in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti20842 – 208421R → S in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti20977 – 209771T → I in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti21384 – 213841H → P in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti21384 – 213841H → P in BAC87568. (PubMed:14702039)Curated
    Sequence conflicti21487 – 214871S → C in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti21487 – 214871S → C in BAC87568. (PubMed:14702039)Curated
    Sequence conflicti21602 – 216021K → Q in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti21602 – 216021K → Q in BAC87568. (PubMed:14702039)Curated
    Sequence conflicti21686 – 2169510YNEPGLDEPP → HHTLQRQSTT in AAK74120. (PubMed:11369781)Curated
    Sequence conflicti21691 – 216911L → P in AAK74120. (PubMed:11369781)Curated

    Polymorphismi

    The number of repeats is highly polymorphic.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti545 – 5451T → A.
    Corresponds to variant rs17000957 [ dbSNP | Ensembl ].
    VAR_056592
    Natural varianti1015 – 10151R → G.
    Corresponds to variant rs17000950 [ dbSNP | Ensembl ].
    VAR_056593
    Natural varianti1032 – 10321S → T.
    Corresponds to variant rs10411228 [ dbSNP | Ensembl ].
    VAR_056594
    Natural varianti1041 – 10411P → S.
    Corresponds to variant rs10406202 [ dbSNP | Ensembl ].
    VAR_056595
    Natural varianti1162 – 11621T → I.
    Corresponds to variant rs17000947 [ dbSNP | Ensembl ].
    VAR_056596
    Natural varianti1266 – 12661K → N.
    Corresponds to variant rs1596797 [ dbSNP | Ensembl ].
    VAR_056597
    Natural varianti1353 – 13531H → Y.
    Corresponds to variant rs12611293 [ dbSNP | Ensembl ].
    VAR_056598
    Natural varianti1400 – 14001K → N.
    Corresponds to variant rs1596798 [ dbSNP | Ensembl ].
    VAR_056599
    Natural varianti1833 – 18331L → F.
    Corresponds to variant rs4520945 [ dbSNP | Ensembl ].
    VAR_056600
    Natural varianti1953 – 19531S → P.
    Corresponds to variant rs1108380 [ dbSNP | Ensembl ].
    VAR_056601
    Natural varianti2058 – 20581S → P.
    Corresponds to variant rs1574479 [ dbSNP | Ensembl ].
    VAR_056602
    Natural varianti2150 – 21501I → V.
    Corresponds to variant rs10407633 [ dbSNP | Ensembl ].
    VAR_056603
    Natural varianti2271 – 22711T → A.
    Corresponds to variant rs11085805 [ dbSNP | Ensembl ].
    VAR_056604
    Natural varianti2288 – 22881V → L.
    Corresponds to variant rs10410933 [ dbSNP | Ensembl ].
    VAR_056605
    Natural varianti2356 – 23561D → E.
    Corresponds to variant rs10416013 [ dbSNP | Ensembl ].
    VAR_056606
    Natural varianti2747 – 27471A → T.
    Corresponds to variant rs10402538 [ dbSNP | Ensembl ].
    VAR_056607
    Natural varianti2786 – 27861M → I.
    Corresponds to variant rs17000886 [ dbSNP | Ensembl ].
    VAR_056608
    Natural varianti2834 – 28341T → M.
    Corresponds to variant rs10407623 [ dbSNP | Ensembl ].
    VAR_056609
    Natural varianti3574 – 35741R → H.
    Corresponds to variant rs2591594 [ dbSNP | Ensembl ].
    VAR_056610
    Natural varianti5743 – 57431H → D.
    Corresponds to variant rs1559172 [ dbSNP | Ensembl ].
    VAR_056611
    Natural varianti5756 – 57561A → T.
    Corresponds to variant rs1559171 [ dbSNP | Ensembl ].
    VAR_056612
    Natural varianti5854 – 58541F → V.
    Corresponds to variant rs1862460 [ dbSNP | Ensembl ].
    VAR_056613
    Natural varianti7065 – 70651T → A.
    Corresponds to variant rs17000770 [ dbSNP | Ensembl ].
    VAR_056614
    Natural varianti7274 – 72741I → V.
    Corresponds to variant rs1867691 [ dbSNP | Ensembl ].
    VAR_056615
    Natural varianti10509 – 105091T → N.
    Corresponds to variant rs11670461 [ dbSNP | Ensembl ].
    VAR_056616

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF414442 mRNA. Translation: AAL65133.2.
    AF361486 mRNA. Translation: AAK74120.3.
    AK128681 mRNA. Translation: BAC87568.1.
    RefSeqiNP_078966.2. NM_024690.2.
    UniGeneiHs.432676.

    Genome annotation databases

    GeneIDi94025.
    KEGGihsa:94025.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    Mucin database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF414442 mRNA. Translation: AAL65133.2 .
    AF361486 mRNA. Translation: AAK74120.3 .
    AK128681 mRNA. Translation: BAC87568.1 .
    RefSeqi NP_078966.2. NM_024690.2.
    UniGenei Hs.432676.

    3D structure databases

    ProteinModelPortali Q8WXI7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125094. 3 interactions.
    STRINGi 9606.ENSP00000381008.

    PTM databases

    PhosphoSitei Q8WXI7.

    Proteomic databases

    MaxQBi Q8WXI7.
    PaxDbi Q8WXI7.
    PRIDEi Q8WXI7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 94025.
    KEGGi hsa:94025.

    Organism-specific databases

    CTDi 94025.
    GeneCardsi GC19M008960.
    H-InvDB HIX0021715.
    HGNCi HGNC:15582. MUC16.
    HPAi CAB055172.
    MIMi 606154. gene.
    neXtProti NX_Q8WXI7.
    PharmGKBi PA31314.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    KOi K16145.

    Enzyme and pathway databases

    Reactomei REACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Miscellaneous databases

    ChiTaRSi MUC16. human.
    GeneWikii CA-125.
    GenomeRNAii 94025.
    NextBioi 78314.
    PROi Q8WXI7.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_MUC16.
    Genevestigatori Q8WXI7.

    Family and domain databases

    Gene3Di 3.30.70.960. 65 hits.
    InterProi IPR028850. MUC16.
    IPR000082. SEA_dom.
    [Graphical view ]
    PANTHERi PTHR14672. PTHR14672. 1 hit.
    Pfami PF01390. SEA. 55 hits.
    [Graphical view ]
    SMARTi SM00200. SEA. 23 hits.
    [Graphical view ]
    SUPFAMi SSF82671. SSF82671. 65 hits.
    PROSITEi PS50024. SEA. 65 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure."
      O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K.
      Tumor Biol. 23:154-169(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-10431, SEQUENCE REVISION TO N-TERMINUS, TISSUE SPECIFICITY, INDUCTION.
    2. "The CA 125 gene: an extracellular superstructure dominated by repeat sequences."
      O'Brien T.J., Beard J.B., Underwood L.J., Dennis R.A., Santin A.D., York L.
      Tumor Biol. 22:348-366(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10432-22152.
    3. "Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16."
      Yin B.W.T., Lloyd K.O.
      J. Biol. Chem. 276:27371-27375(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8297-22152, PROTEIN SEQUENCE OF 21360-21365 AND 21983-21995, TISSUE SPECIFICITY.
    4. Lloyd K.O., Yin B.W.T.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20473-21695.
      Tissue: Uterus.
    6. "CA125 phosphorylation is associated with its secretion from the WISH human amnion cell line."
      Fendrick J.L., Konishi I., Geary S.M., Parmley T.H., Quirk J.G. Jr., O'Brien T.J.
      Tumor Biol. 18:278-289(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    7. "Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125."
      Kui Wong N., Easton R.L., Panico M., Sutton-Smith M., Morrison J.C., Lattanzio F.A., Morris H.R., Clark G.F., Dell A., Patankar M.S.
      J. Biol. Chem. 278:28619-28634(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION.
    8. "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion."
      Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., Miyajima A.
      J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MSLN.
    9. "Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer."
      McLemore M.R., Aouizerat B.
      Biol. Res. Nurs. 6:262-267(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, POLYMORPHISM.
    10. "Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye."
      Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K.
      Invest. Ophthalmol. Vis. Sci. 47:113-119(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiMUC16_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXI7
    Secondary accession number(s): Q6ZQW5, Q96RK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3