Q8WXI2 (CNKR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Connector enhancer of kinase suppressor of ras 2
Short name=Connector enhancer of KSR 2

Alternative name(s):
CNK homolog protein 2
Short name=CNK2

Gene names

Name:	CNKSR2
Synonyms:	CNK2, KIAA0902, KSR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1034 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as an adapter protein or regulator of Ras signaling pathways. Ref.1
Subunit structure	Interacts with RAF1, RAB2L and RAL GTPase proteins. Ref.1
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein.
Post-translational modification	Phosphorylated on tyrosine. Ref.1
Sequence similarities	Belongs to the CNKSR family. Contains 1 CRIC domain. Contains 1 DUF1170 domain. Contains 1 PDZ (DHR) domain. Contains 1 PH domain. Contains 1 SAM (sterile alpha motif) domain.
Sequence caution	Isoform 2: The sequence BAA74925.2 differs from that shown. Reason: Frameshift at positions 859, 929, 985 and 1019.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell neuron projection Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara postsynaptic membrane Inferred from electronic annotation. Source: Compara
Molecular_function	phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WXI2-1)

Also known as: CNK2A; KSR2A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WXI2-2)

Also known as: CNK2B; KSR2B;

The sequence of this isoform differs from the canonical sequence as follows:
     899-1034: Missing.

Isoform 3 (identifier: Q8WXI2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     271-319: Missing.
     899-1034: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8WXI2-5)

The sequence of this isoform differs from the canonical sequence as follows:
     435-464: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1034

1034

Connector enhancer of kinase suppressor of ras 2

PRO_0000089970

Regions

Domain

11 – 76

66

SAM

Domain

84 – 178

95

CRIC

Domain

215 – 297

83

PDZ

Domain

332 – 515

184

DUF1170

Domain

570 – 669

100

PH

Coiled coil

875 – 904

30

Potential

Compositional bias

354 – 357

4

Poly-Pro

Compositional bias

703 – 706

4

Poly-Pro

Compositional bias

875 – 888

14

Poly-Glu

Amino acid modifications

Modified residue

248

1

Phosphoserine By similarity

Modified residue

325

1

Phosphoserine By similarity

Modified residue

390

1

Phosphoserine By similarity

Modified residue

467

1

Phosphoserine By similarity

Modified residue

846

1

Phosphothreonine By similarity

Modified residue

908

1

Phosphoserine Ref.7 Ref.8

Natural variations

Alternative sequence

271 – 319

49

Missing in isoform 3.

VSP_043168

Alternative sequence

435 – 464

30

Missing in isoform 4.

VSP_043169

Alternative sequence

899 – 1034

136

Missing in isoform 2 and isoform 3.

VSP_010887

Natural variant

46

1

R → H in a colorectal cancer sample; somatic mutation. Ref.10

VAR_035681

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1034

Helix Strand Turn

Details...

Helix

8 – 10

3

Helix

13 – 21

9

Helix

25 – 30

6

Helix

31 – 37

7

Helix

41 – 45

5

Helix

49 – 54

6

Helix

60 – 77

18

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (CNK2A) (KSR2A) [UniParc]. Last modified March 1, 2002. Version 1. Checksum: E43DB0D8D72D954C	FASTA	1,034	117,535
	10 20 30 40 50 60 MALIMEPVSK WSPSQVVDWM KGLDDCLQQY IKNFEREKIS GDQLLRITHQ ELEDLGVSRI 70 80 90 100 110 120 GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ NFITGRRRSG HYDGRTSRKL 130 140 150 160 170 180 PNDFLTSVVD LIGAAKSLLA WLDRSPFAAV TDYSVTRNNV IQLCLELTTI VQQDCTVYET 190 200 210 220 230 240 ENKILHVCKT LSGVCDHIIS LSSDPLVSQS AHLEVIQLAN IKPSEGLGMY IKSTYDGLHV 250 260 270 280 290 300 ITGTTENSPA DRCKKIHAGD EVIQVNHQTV VGWQLKNLVN ALREDPSGVI LTLKKRPQSM 310 320 330 340 350 360 LTSAPALLKN MRWKPLALQP LIPRSPTSSV ATPSSTISTP TKRDSSALQD LYIPPPPAEP 370 380 390 400 410 420 YIPRDEKGNL PCEDLRGHMV GKPVHKGSES PNSFLDQEYR KRFNIVEEDT VLYCYEYEKG 430 440 450 460 470 480 RSSSQGRRES TPTYGKLRPI SMPVEYNWVG DYEDPNKMKR DSRRENSLLR YMSNEKIAQE 490 500 510 520 530 540 EYMFQRNSKK DTGKKSKKKG DKSNSPTHYS LLPSLQMDAL RQDIMGTPVP ETTLYHTFQQ 550 560 570 580 590 600 SSLQHKSKKK NKGPIAGKSK RRISCKDLGR GDCEGWLWKK KDAKSYFSQK WKKYWFVLKD 610 620 630 640 650 660 ASLYWYINEE DEKAEGFISL PEFKIDRASE CRKKYAFKAC HPKIKSFYFA AEHLDDMNRW 670 680 690 700 710 720 LNRINMLTAG YAERERIKQE QDYWSESDKE EADTPSTPKQ DSPPPPYDTY PRPPSMSCAS 730 740 750 760 770 780 PYVEAKHSRL SSTETSQSQS SHEEFRQEVT GSSAVSPIRK TASQRRSWQD LIETPLTSSG 790 800 810 820 830 840 LHYLQTLPLE DSVFSDSAAI SPEHRRQSTL PTQKCHLQDH YGPYPLAESE RMQVLNGNGG 850 860 870 880 890 900 KPRSFTLPRD SGFNHCCLNA PVSACDPQDD VQPPEVEEEE EEEEEEGEAA GENIGEKSES 910 920 930 940 950 960 REEKLGDSLQ DLYRALEQAS LSPLGEHRIS TKMEYKLSFI KRCNDPVMNE KLHRLRILKS 970 980 990 1000 1010 1020 TLKAREGEVA IIDKVLDNPD LTSKEFQQWK QMYLDLFLDI CQNTTSNDPL SISSEVDVIT 1030 SSLAHTHSYI ETHV
	Isoform 2 (CNK2B) (KSR2B) [UniParc]. Checksum: 4DFEFE26960DF70C	FASTA	898	101,874
	10 20 30 40 50 60 MALIMEPVSK WSPSQVVDWM KGLDDCLQQY IKNFEREKIS GDQLLRITHQ ELEDLGVSRI 70 80 90 100 110 120 GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ NFITGRRRSG HYDGRTSRKL 130 140 150 160 170 180 PNDFLTSVVD LIGAAKSLLA WLDRSPFAAV TDYSVTRNNV IQLCLELTTI VQQDCTVYET 190 200 210 220 230 240 ENKILHVCKT LSGVCDHIIS LSSDPLVSQS AHLEVIQLAN IKPSEGLGMY IKSTYDGLHV 250 260 270 280 290 300 ITGTTENSPA DRCKKIHAGD EVIQVNHQTV VGWQLKNLVN ALREDPSGVI LTLKKRPQSM 310 320 330 340 350 360 LTSAPALLKN MRWKPLALQP LIPRSPTSSV ATPSSTISTP TKRDSSALQD LYIPPPPAEP 370 380 390 400 410 420 YIPRDEKGNL PCEDLRGHMV GKPVHKGSES PNSFLDQEYR KRFNIVEEDT VLYCYEYEKG 430 440 450 460 470 480 RSSSQGRRES TPTYGKLRPI SMPVEYNWVG DYEDPNKMKR DSRRENSLLR YMSNEKIAQE 490 500 510 520 530 540 EYMFQRNSKK DTGKKSKKKG DKSNSPTHYS LLPSLQMDAL RQDIMGTPVP ETTLYHTFQQ 550 560 570 580 590 600 SSLQHKSKKK NKGPIAGKSK RRISCKDLGR GDCEGWLWKK KDAKSYFSQK WKKYWFVLKD 610 620 630 640 650 660 ASLYWYINEE DEKAEGFISL PEFKIDRASE CRKKYAFKAC HPKIKSFYFA AEHLDDMNRW 670 680 690 700 710 720 LNRINMLTAG YAERERIKQE QDYWSESDKE EADTPSTPKQ DSPPPPYDTY PRPPSMSCAS 730 740 750 760 770 780 PYVEAKHSRL SSTETSQSQS SHEEFRQEVT GSSAVSPIRK TASQRRSWQD LIETPLTSSG 790 800 810 820 830 840 LHYLQTLPLE DSVFSDSAAI SPEHRRQSTL PTQKCHLQDH YGPYPLAESE RMQVLNGNGG 850 860 870 880 890 KPRSFTLPRD SGFNHCCLNA PVSACDPQDD VQPPEVEEEE EEEEEEGEAA GENIGEKS
	Isoform 3 [UniParc]. Checksum: D95B2A7AC2639040	FASTA	849	96,366
	10 20 30 40 50 60 MALIMEPVSK WSPSQVVDWM KGLDDCLQQY IKNFEREKIS GDQLLRITHQ ELEDLGVSRI 70 80 90 100 110 120 GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ NFITGRRRSG HYDGRTSRKL 130 140 150 160 170 180 PNDFLTSVVD LIGAAKSLLA WLDRSPFAAV TDYSVTRNNV IQLCLELTTI VQQDCTVYET 190 200 210 220 230 240 ENKILHVCKT LSGVCDHIIS LSSDPLVSQS AHLEVIQLAN IKPSEGLGMY IKSTYDGLHV 250 260 270 280 290 300 ITGTTENSPA DRCKKIHAGD EVIQVNHQTV PLIPRSPTSS VATPSSTIST PTKRDSSALQ 310 320 330 340 350 360 DLYIPPPPAE PYIPRDEKGN LPCEDLRGHM VGKPVHKGSE SPNSFLDQEY RKRFNIVEED 370 380 390 400 410 420 TVLYCYEYEK GRSSSQGRRE STPTYGKLRP ISMPVEYNWV GDYEDPNKMK RDSRRENSLL 430 440 450 460 470 480 RYMSNEKIAQ EEYMFQRNSK KDTGKKSKKK GDKSNSPTHY SLLPSLQMDA LRQDIMGTPV 490 500 510 520 530 540 PETTLYHTFQ QSSLQHKSKK KNKGPIAGKS KRRISCKDLG RGDCEGWLWK KKDAKSYFSQ 550 560 570 580 590 600 KWKKYWFVLK DASLYWYINE EDEKAEGFIS LPEFKIDRAS ECRKKYAFKA CHPKIKSFYF 610 620 630 640 650 660 AAEHLDDMNR WLNRINMLTA GYAERERIKQ EQDYWSESDK EEADTPSTPK QDSPPPPYDT 670 680 690 700 710 720 YPRPPSMSCA SPYVEAKHSR LSSTETSQSQ SSHEEFRQEV TGSSAVSPIR KTASQRRSWQ 730 740 750 760 770 780 DLIETPLTSS GLHYLQTLPL EDSVFSDSAA ISPEHRRQST LPTQKCHLQD HYGPYPLAES 790 800 810 820 830 840 ERMQVLNGNG GKPRSFTLPR DSGFNHCCLN APVSACDPQD DVQPPEVEEE EEEEEEEGEA AGENIGEKS
	Isoform 4 [UniParc]. Checksum: C635EA09FA4E6696	FASTA	1,004	113,914
	10 20 30 40 50 60 MALIMEPVSK WSPSQVVDWM KGLDDCLQQY IKNFEREKIS GDQLLRITHQ ELEDLGVSRI 70 80 90 100 110 120 GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ NFITGRRRSG HYDGRTSRKL 130 140 150 160 170 180 PNDFLTSVVD LIGAAKSLLA WLDRSPFAAV TDYSVTRNNV IQLCLELTTI VQQDCTVYET 190 200 210 220 230 240 ENKILHVCKT LSGVCDHIIS LSSDPLVSQS AHLEVIQLAN IKPSEGLGMY IKSTYDGLHV 250 260 270 280 290 300 ITGTTENSPA DRCKKIHAGD EVIQVNHQTV VGWQLKNLVN ALREDPSGVI LTLKKRPQSM 310 320 330 340 350 360 LTSAPALLKN MRWKPLALQP LIPRSPTSSV ATPSSTISTP TKRDSSALQD LYIPPPPAEP 370 380 390 400 410 420 YIPRDEKGNL PCEDLRGHMV GKPVHKGSES PNSFLDQEYR KRFNIVEEDT VLYCYEYEKG 430 440 450 460 470 480 RSSSQGRRES TPTYENSLLR YMSNEKIAQE EYMFQRNSKK DTGKKSKKKG DKSNSPTHYS 490 500 510 520 530 540 LLPSLQMDAL RQDIMGTPVP ETTLYHTFQQ SSLQHKSKKK NKGPIAGKSK RRISCKDLGR 550 560 570 580 590 600 GDCEGWLWKK KDAKSYFSQK WKKYWFVLKD ASLYWYINEE DEKAEGFISL PEFKIDRASE 610 620 630 640 650 660 CRKKYAFKAC HPKIKSFYFA AEHLDDMNRW LNRINMLTAG YAERERIKQE QDYWSESDKE 670 680 690 700 710 720 EADTPSTPKQ DSPPPPYDTY PRPPSMSCAS PYVEAKHSRL SSTETSQSQS SHEEFRQEVT 730 740 750 760 770 780 GSSAVSPIRK TASQRRSWQD LIETPLTSSG LHYLQTLPLE DSVFSDSAAI SPEHRRQSTL 790 800 810 820 830 840 PTQKCHLQDH YGPYPLAESE RMQVLNGNGG KPRSFTLPRD SGFNHCCLNA PVSACDPQDD 850 860 870 880 890 900 VQPPEVEEEE EEEEEEGEAA GENIGEKSES REEKLGDSLQ DLYRALEQAS LSPLGEHRIS 910 920 930 940 950 960 TKMEYKLSFI KRCNDPVMNE KLHRLRILKS TLKAREGEVA IIDKVLDNPD LTSKEFQQWK 970 980 990 1000 QMYLDLFLDI CQNTTSNDPL SISSEVDVIT SSLAHTHSYI ETHV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf." Lanigan T.M., Liu A., Huang Y.Z., Mei L., Margolis B., Guan K.-L. FASEB J. 17:2048-2060(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, INTERACTION WITH RAF1; RAB2L AND RAL GTPASE PROTEINS, PHOSPHORYLATION. Tissue: Fetal brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Brain and Testis.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908, MASS SPECTROMETRY.
[9]	"Solution structure of the N-terminal SAM-domain of human KIAA0902 protein (connector enhancer of kinase suppressor of RAS 2)." RIKEN structural genomics initiative (RSGI) Submitted (JUL-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 8-79.
[10]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-46.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF418269 mRNA. Translation: AAL60502.1.
AF418270 mRNA. Translation: AAL60503.1.
AB020709 mRNA. Translation: BAA74925.2. Frameshift.
AK294728 mRNA. Translation: BAG57875.1.
AL928874, AL772392, AL807781 Genomic DNA. Translation: CAH70863.1.
AL928874, AL772392, AL807781 Genomic DNA. Translation: CAH70864.1.
AL807781, AL772392, AL928874 Genomic DNA. Translation: CAI39866.1.
AL807781, AL772392, AL928874 Genomic DNA. Translation: CAI39867.1.
AL772392, AL807781, AL928874 Genomic DNA. Translation: CAI40765.1.
AL772392, AL807781, AL928874 Genomic DNA. Translation: CAI40766.1.
CH471074 Genomic DNA. Translation: EAW98977.1.
BC126121 mRNA. Translation: AAI26122.1.
BC136289 mRNA. Translation: AAI36290.1.
BC143839 mRNA. Translation: AAI43840.1.

IPI

IPI00435208.
IPI00435209.
IPI00909333.
IPI00939128.

RefSeq

NP_001162118.1. NM_001168647.1.
NP_001162119.1. NM_001168648.1.
NP_001162120.1. NM_001168649.1.
NP_055742.2. NM_014927.3.

UniGene

Hs.555917.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EAN	NMR	-	A	8-77	[»]
3BS5	X-ray	2.00	B	5-84	[»]

ProteinModelPortal

Q8WXI2.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29736N.

IntAct

Q8WXI2. 2 interactions.

MINT

MINT-1784713.

STRING

9606.ENSP00000368824.

PTM databases

PhosphoSite

Q8WXI2.

Polymorphism databases

DMDM

50400586.

Proteomic databases

PaxDb

Q8WXI2.

PRIDE

Q8WXI2.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000279451; ENSP00000279451; ENSG00000149970.
ENST00000379510; ENSP00000368824; ENSG00000149970.
ENST00000425654; ENSP00000397906; ENSG00000149970.
ENST00000543067; ENSP00000444633; ENSG00000149970.

GeneID

22866.

KEGG

hsa:22866.

UCSC

uc004czw.3. human.

Organism-specific databases

CTD

22866.

GeneCards

GC0XP021302.

HGNC

HGNC:19701. CNKSR2.

HPA

HPA001502.

MIM

300724. gene.

neXtProt

NX_Q8WXI2.

PharmGKB

PA134867759.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG255577.

HOGENOM

HOG000231501.

HOVERGEN

HBG051040.

InParanoid

Q8WXI2.

OMA

STKLEYK.

OrthoDB

EOG4G1MFQ.

PhylomeDB

Q8WXI2.

Gene expression databases

ArrayExpress

Q8WXI2.

Bgee

Q8WXI2.

CleanEx

HS_CNKSR2.
HS_KSR2.

Genevestigator

Q8WXI2.

GermOnline

ENSG00000149970. Homo sapiens.

Family and domain databases

Gene3D

1.10.150.50. 1 hit.
2.30.29.30. 1 hit.

InterPro

IPR010599. CNKSR2.
IPR017874. CRIC_domain.
IPR019555. CRIC_domain_Chordata.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]

Pfam

PF10534. CRIC_ras_sig. 1 hit.
PF06663. DUF1170. 1 hit.
PF00595. PDZ. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]

SMART

SM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.
SSF47769. SAM_homology. 1 hit.

PROSITE

PS51290. CRIC. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL1938216.

EvolutionaryTrace

Q8WXI2.

GenomeRNAi

22866.

NextBio

43387.

SOURCE

Search...

Entry information

Entry name

CNKR2_HUMAN

Accession

Primary (citable) accession number: Q8WXI2
Secondary accession number(s): B4DGR4 , B7ZLJ1, B9EG83, E7ESA4, O94976, Q5JPK4, Q5JPN0, Q8WXI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.