Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WXI2

- CNKR2_HUMAN

UniProt

Q8WXI2 - CNKR2_HUMAN

Protein

Connector enhancer of kinase suppressor of ras 2

Gene

CNKSR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May function as an adapter protein or regulator of Ras signaling pathways.1 Publication

    GO - Biological processi

    1. regulation of signal transduction Source: InterPro

    Enzyme and pathway databases

    SignaLinkiQ8WXI2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Connector enhancer of kinase suppressor of ras 2
    Short name:
    Connector enhancer of KSR 2
    Alternative name(s):
    CNK homolog protein 2
    Short name:
    CNK2
    Gene namesi
    Name:CNKSR2
    Synonyms:CNK2, KIAA0902, KSR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:19701. CNKSR2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi apparatus Source: HPA
    3. neuronal cell body Source: Ensembl
    4. neuron projection Source: Ensembl
    5. plasma membrane Source: HPA
    6. postsynaptic membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134867759.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10341034Connector enhancer of kinase suppressor of ras 2PRO_0000089970Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei908 – 9081Phosphoserine3 Publications

    Post-translational modificationi

    Phosphorylated on tyrosine.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WXI2.
    PaxDbiQ8WXI2.
    PRIDEiQ8WXI2.

    PTM databases

    PhosphoSiteiQ8WXI2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WXI2.
    BgeeiQ8WXI2.
    CleanExiHS_CNKSR2.
    HS_KSR2.
    GenevestigatoriQ8WXI2.

    Organism-specific databases

    HPAiHPA001502.

    Interactioni

    Subunit structurei

    Interacts with RAF1, RAB2L and RAL GTPase proteins.1 Publication

    Protein-protein interaction databases

    BioGridi116534. 7 interactions.
    DIPiDIP-29736N.
    IntActiQ8WXI2. 3 interactions.
    MINTiMINT-1784713.
    STRINGi9606.ENSP00000368824.

    Structurei

    Secondary structure

    1
    1034
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi8 – 103
    Helixi13 – 219
    Helixi25 – 306
    Helixi31 – 377
    Helixi41 – 455
    Helixi49 – 546
    Helixi60 – 7718

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EANNMR-A8-77[»]
    3BS5X-ray2.00B5-84[»]
    ProteinModelPortaliQ8WXI2.
    SMRiQ8WXI2. Positions 6-80, 240-295, 575-661.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WXI2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 7666SAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini84 – 17895CRICPROSITE-ProRule annotationAdd
    BLAST
    Domaini215 – 29783PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini332 – 515184DUF1170Add
    BLAST
    Domaini570 – 669100PHPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili875 – 90430Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi354 – 3574Poly-Pro
    Compositional biasi703 – 7064Poly-Pro
    Compositional biasi875 – 88814Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CNKSR family.Curated
    Contains 1 CRIC domain.PROSITE-ProRule annotation
    Contains 1 DUF1170 domain.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG255577.
    HOGENOMiHOG000231501.
    HOVERGENiHBG051040.
    InParanoidiQ8WXI2.
    KOiK17536.
    OMAiSTKLEYK.
    OrthoDBiEOG71ZP0W.
    PhylomeDBiQ8WXI2.
    TreeFamiTF326495.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR010599. CNKSR2.
    IPR017874. CRIC_domain.
    IPR019555. CRIC_domain_Chordata.
    IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF10534. CRIC_ras_sig. 1 hit.
    PF06663. DUF1170. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEiPS51290. CRIC. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WXI2-1) [UniParc]FASTAAdd to Basket

    Also known as: CNK2A, KSR2A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALIMEPVSK WSPSQVVDWM KGLDDCLQQY IKNFEREKIS GDQLLRITHQ     50
    ELEDLGVSRI GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ 100
    NFITGRRRSG HYDGRTSRKL PNDFLTSVVD LIGAAKSLLA WLDRSPFAAV 150
    TDYSVTRNNV IQLCLELTTI VQQDCTVYET ENKILHVCKT LSGVCDHIIS 200
    LSSDPLVSQS AHLEVIQLAN IKPSEGLGMY IKSTYDGLHV ITGTTENSPA 250
    DRCKKIHAGD EVIQVNHQTV VGWQLKNLVN ALREDPSGVI LTLKKRPQSM 300
    LTSAPALLKN MRWKPLALQP LIPRSPTSSV ATPSSTISTP TKRDSSALQD 350
    LYIPPPPAEP YIPRDEKGNL PCEDLRGHMV GKPVHKGSES PNSFLDQEYR 400
    KRFNIVEEDT VLYCYEYEKG RSSSQGRRES TPTYGKLRPI SMPVEYNWVG 450
    DYEDPNKMKR DSRRENSLLR YMSNEKIAQE EYMFQRNSKK DTGKKSKKKG 500
    DKSNSPTHYS LLPSLQMDAL RQDIMGTPVP ETTLYHTFQQ SSLQHKSKKK 550
    NKGPIAGKSK RRISCKDLGR GDCEGWLWKK KDAKSYFSQK WKKYWFVLKD 600
    ASLYWYINEE DEKAEGFISL PEFKIDRASE CRKKYAFKAC HPKIKSFYFA 650
    AEHLDDMNRW LNRINMLTAG YAERERIKQE QDYWSESDKE EADTPSTPKQ 700
    DSPPPPYDTY PRPPSMSCAS PYVEAKHSRL SSTETSQSQS SHEEFRQEVT 750
    GSSAVSPIRK TASQRRSWQD LIETPLTSSG LHYLQTLPLE DSVFSDSAAI 800
    SPEHRRQSTL PTQKCHLQDH YGPYPLAESE RMQVLNGNGG KPRSFTLPRD 850
    SGFNHCCLNA PVSACDPQDD VQPPEVEEEE EEEEEEGEAA GENIGEKSES 900
    REEKLGDSLQ DLYRALEQAS LSPLGEHRIS TKMEYKLSFI KRCNDPVMNE 950
    KLHRLRILKS TLKAREGEVA IIDKVLDNPD LTSKEFQQWK QMYLDLFLDI 1000
    CQNTTSNDPL SISSEVDVIT SSLAHTHSYI ETHV 1034
    Length:1,034
    Mass (Da):117,535
    Last modified:March 1, 2002 - v1
    Checksum:iE43DB0D8D72D954C
    GO
    Isoform 2 (identifier: Q8WXI2-2) [UniParc]FASTAAdd to Basket

    Also known as: CNK2B, KSR2B

    The sequence of this isoform differs from the canonical sequence as follows:
         899-1034: Missing.

    Show »
    Length:898
    Mass (Da):101,874
    Checksum:i4DFEFE26960DF70C
    GO
    Isoform 3 (identifier: Q8WXI2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         271-319: Missing.
         899-1034: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:849
    Mass (Da):96,366
    Checksum:iD95B2A7AC2639040
    GO
    Isoform 4 (identifier: Q8WXI2-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         435-464: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,004
    Mass (Da):113,914
    Checksum:iC635EA09FA4E6696
    GO

    Sequence cautioni

    Isoform 2 : The sequence BAA74925.2 differs from that shown. Reason: Frameshift at positions 859, 929, 985 and 1019.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035681

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei271 – 31949Missing in isoform 3. 1 PublicationVSP_043168Add
    BLAST
    Alternative sequencei435 – 46430Missing in isoform 4. 1 PublicationVSP_043169Add
    BLAST
    Alternative sequencei899 – 1034136Missing in isoform 2 and isoform 3. 3 PublicationsVSP_010887Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418269 mRNA. Translation: AAL60502.1.
    AF418270 mRNA. Translation: AAL60503.1.
    AB020709 mRNA. Translation: BAA74925.2. Frameshift.
    AK294728 mRNA. Translation: BAG57875.1.
    AL928874, AL772392, AL807781 Genomic DNA. Translation: CAH70863.1.
    AL928874, AL772392, AL807781 Genomic DNA. Translation: CAH70864.1.
    AL807781, AL772392, AL928874 Genomic DNA. Translation: CAI39866.1.
    AL807781, AL772392, AL928874 Genomic DNA. Translation: CAI39867.1.
    AL772392, AL807781, AL928874 Genomic DNA. Translation: CAI40765.1.
    AL772392, AL807781, AL928874 Genomic DNA. Translation: CAI40766.1.
    CH471074 Genomic DNA. Translation: EAW98977.1.
    BC126121 mRNA. Translation: AAI26122.1.
    BC136289 mRNA. Translation: AAI36290.1.
    BC143839 mRNA. Translation: AAI43840.1.
    CCDSiCCDS14198.1. [Q8WXI2-1]
    CCDS55387.1. [Q8WXI2-2]
    CCDS55388.1. [Q8WXI2-5]
    CCDS55389.1. [Q8WXI2-4]
    RefSeqiNP_001162118.1. NM_001168647.1. [Q8WXI2-5]
    NP_001162119.1. NM_001168648.1. [Q8WXI2-2]
    NP_001162120.1. NM_001168649.1. [Q8WXI2-4]
    NP_055742.2. NM_014927.3. [Q8WXI2-1]
    UniGeneiHs.555917.

    Genome annotation databases

    EnsembliENST00000279451; ENSP00000279451; ENSG00000149970. [Q8WXI2-2]
    ENST00000379510; ENSP00000368824; ENSG00000149970. [Q8WXI2-1]
    ENST00000425654; ENSP00000397906; ENSG00000149970. [Q8WXI2-5]
    ENST00000543067; ENSP00000444633; ENSG00000149970. [Q8WXI2-4]
    GeneIDi22866.
    KEGGihsa:22866.
    UCSCiuc004czw.3. human. [Q8WXI2-1]
    uc011mjn.2. human. [Q8WXI2-4]
    uc011mjo.2. human. [Q8WXI2-5]

    Polymorphism databases

    DMDMi50400586.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418269 mRNA. Translation: AAL60502.1 .
    AF418270 mRNA. Translation: AAL60503.1 .
    AB020709 mRNA. Translation: BAA74925.2 . Frameshift.
    AK294728 mRNA. Translation: BAG57875.1 .
    AL928874 , AL772392 , AL807781 Genomic DNA. Translation: CAH70863.1 .
    AL928874 , AL772392 , AL807781 Genomic DNA. Translation: CAH70864.1 .
    AL807781 , AL772392 , AL928874 Genomic DNA. Translation: CAI39866.1 .
    AL807781 , AL772392 , AL928874 Genomic DNA. Translation: CAI39867.1 .
    AL772392 , AL807781 , AL928874 Genomic DNA. Translation: CAI40765.1 .
    AL772392 , AL807781 , AL928874 Genomic DNA. Translation: CAI40766.1 .
    CH471074 Genomic DNA. Translation: EAW98977.1 .
    BC126121 mRNA. Translation: AAI26122.1 .
    BC136289 mRNA. Translation: AAI36290.1 .
    BC143839 mRNA. Translation: AAI43840.1 .
    CCDSi CCDS14198.1. [Q8WXI2-1 ]
    CCDS55387.1. [Q8WXI2-2 ]
    CCDS55388.1. [Q8WXI2-5 ]
    CCDS55389.1. [Q8WXI2-4 ]
    RefSeqi NP_001162118.1. NM_001168647.1. [Q8WXI2-5 ]
    NP_001162119.1. NM_001168648.1. [Q8WXI2-2 ]
    NP_001162120.1. NM_001168649.1. [Q8WXI2-4 ]
    NP_055742.2. NM_014927.3. [Q8WXI2-1 ]
    UniGenei Hs.555917.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EAN NMR - A 8-77 [» ]
    3BS5 X-ray 2.00 B 5-84 [» ]
    ProteinModelPortali Q8WXI2.
    SMRi Q8WXI2. Positions 6-80, 240-295, 575-661.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116534. 7 interactions.
    DIPi DIP-29736N.
    IntActi Q8WXI2. 3 interactions.
    MINTi MINT-1784713.
    STRINGi 9606.ENSP00000368824.

    PTM databases

    PhosphoSitei Q8WXI2.

    Polymorphism databases

    DMDMi 50400586.

    Proteomic databases

    MaxQBi Q8WXI2.
    PaxDbi Q8WXI2.
    PRIDEi Q8WXI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279451 ; ENSP00000279451 ; ENSG00000149970 . [Q8WXI2-2 ]
    ENST00000379510 ; ENSP00000368824 ; ENSG00000149970 . [Q8WXI2-1 ]
    ENST00000425654 ; ENSP00000397906 ; ENSG00000149970 . [Q8WXI2-5 ]
    ENST00000543067 ; ENSP00000444633 ; ENSG00000149970 . [Q8WXI2-4 ]
    GeneIDi 22866.
    KEGGi hsa:22866.
    UCSCi uc004czw.3. human. [Q8WXI2-1 ]
    uc011mjn.2. human. [Q8WXI2-4 ]
    uc011mjo.2. human. [Q8WXI2-5 ]

    Organism-specific databases

    CTDi 22866.
    GeneCardsi GC0XP021302.
    HGNCi HGNC:19701. CNKSR2.
    HPAi HPA001502.
    MIMi 300724. gene.
    neXtProti NX_Q8WXI2.
    PharmGKBi PA134867759.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255577.
    HOGENOMi HOG000231501.
    HOVERGENi HBG051040.
    InParanoidi Q8WXI2.
    KOi K17536.
    OMAi STKLEYK.
    OrthoDBi EOG71ZP0W.
    PhylomeDBi Q8WXI2.
    TreeFami TF326495.

    Enzyme and pathway databases

    SignaLinki Q8WXI2.

    Miscellaneous databases

    EvolutionaryTracei Q8WXI2.
    GeneWikii CNKSR2.
    GenomeRNAii 22866.
    NextBioi 43387.
    PROi Q8WXI2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WXI2.
    Bgeei Q8WXI2.
    CleanExi HS_CNKSR2.
    HS_KSR2.
    Genevestigatori Q8WXI2.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR010599. CNKSR2.
    IPR017874. CRIC_domain.
    IPR019555. CRIC_domain_Chordata.
    IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF10534. CRIC_ras_sig. 1 hit.
    PF06663. DUF1170. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEi PS51290. CRIC. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf."
      Lanigan T.M., Liu A., Huang Y.Z., Mei L., Margolis B., Guan K.-L.
      FASEB J. 17:2048-2060(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, INTERACTION WITH RAF1; RAB2L AND RAL GTPASE PROTEINS, PHOSPHORYLATION.
      Tissue: Fetal brain.
    2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Brain and Testis.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Solution structure of the N-terminal SAM-domain of human KIAA0902 protein (connector enhancer of kinase suppressor of RAS 2)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUL-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 8-79.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-46.

    Entry informationi

    Entry nameiCNKR2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXI2
    Secondary accession number(s): B4DGR4
    , B7ZLJ1, B9EG83, E7ESA4, O94976, Q5JPK4, Q5JPN0, Q8WXI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3