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Protein

Ras-related protein Rab-40A

Gene

RAB40A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPBy similarity8
Nucleotide bindingi69 – 73GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-40A
Alternative name(s):
SOCS box-containing protein RAR2A
Short name:
Protein Rar-2
Gene namesi
Name:RAB40A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000172476.3
HGNCiHGNC:18283 RAB40A
neXtProtiNX_Q8WXH6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172476
PharmGKBiPA34137

Polymorphism and mutation databases

BioMutaiRAB40A
DMDMi83287759

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212571 – 274Ras-related protein Rab-40AAdd BLAST274
PropeptideiPRO_0000370830275 – 277Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi269S-palmitoyl cysteineSequence analysis1
Modified residuei274Cysteine methyl esterSequence analysis1
Lipidationi274S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ8WXH6
PRIDEiQ8WXH6

PTM databases

iPTMnetiQ8WXH6
PhosphoSitePlusiQ8WXH6

Expressioni

Gene expression databases

BgeeiENSG00000172476
CleanExiHS_RAB40A
GenevisibleiQ8WXH6 HS

Interactioni

Protein-protein interaction databases

BioGridi126773, 16 interactors
IntActiQ8WXH6, 2 interactors
MINTiQ8WXH6
STRINGi9606.ENSP00000305648

Structurei

3D structure databases

ProteinModelPortaliQ8WXH6
SMRiQ8WXH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 228SOCS boxPROSITE-ProRule annotationAdd BLAST54

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0078 Eukaryota
ENOG410XPUI LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233967
HOVERGENiHBG009351
InParanoidiQ8WXH6
KOiK07928
OMAiLRHRMNW
OrthoDBiEOG091G0DGV
PhylomeDBiQ8WXH6
TreeFamiTF323230

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WXH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPGSPDQA YDFLLKFLLV GDRDVGKSEI LESLQDGAAE SPYSHLGGID
60 70 80 90 100
YKTTTILLDG QRVKLKLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW
110 120 130 140 150
SFEGMDRWIK KIEEHAPGVP KILVGNRLHL AFKRQVPREQ AQAYAERLGV
160 170 180 190 200
TFFEVSPLCN FNIIESFTEL ARIVLLRHRM NWLGRPSKVL SLQDLCCRTI
210 220 230 240 250
VSCTPVHLVD KLPLPSTLRS HLKSFSMAKG LNARMMRGLS YSLTTSSTHK
260 270
SSLCKVEIVC PPQSPPKNCT RNSCKIS
Length:277
Mass (Da):31,076
Last modified:September 13, 2005 - v2
Checksum:iEB00BFF4E56A8577
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250K → KR in AAL60514 (Ref. 2) Curated1
Sequence conflicti257E → K in AAL60514 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03443545H → L. Corresponds to variant dbSNP:rs1180895Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132748 mRNA Translation: AAL75949.1
AF422143 mRNA Translation: AAL60514.1
AB232637 mRNA Translation: BAF02899.1
Z69733 Genomic DNA No translation available.
BC074854 mRNA Translation: AAH74854.1
BC074855 mRNA Translation: AAH74855.1
BC113501 mRNA Translation: AAI13502.1
BC117232 mRNA Translation: AAI17233.1
CCDSiCCDS35357.1
RefSeqiNP_543155.2, NM_080879.2
XP_005262140.1, XM_005262083.4
XP_011529174.1, XM_011530872.2
UniGeneiHs.706904

Genome annotation databases

EnsembliENST00000304236; ENSP00000305648; ENSG00000172476
ENST00000372633; ENSP00000361716; ENSG00000172476
GeneIDi142684
KEGGihsa:142684
UCSCiuc004ekk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRB40A_HUMAN
AccessioniPrimary (citable) accession number: Q8WXH6
Secondary accession number(s): O00407
, Q17RQ5, Q6DK06, Q8TF06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: September 13, 2005
Last modified: February 28, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health