Q8WXH6 (RB40A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-40A

Alternative name(s):
SOCS box-containing protein RAR2A
Short name=Protein Rar-2

Gene names

Name:

RAB40A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Palmitate Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Ras-related protein Rab-40A		PRO_0000121257
	Propeptide	275 – 277	3	Removed in mature form Potential		PRO_0000370830
Regions
	Domain	175 – 228	54	SOCS box
	Nucleotide binding	21 – 28	8	GTP By similarity
	Nucleotide binding	69 – 73	5	GTP By similarity
	Nucleotide binding	126 – 129	4	GTP By similarity
Amino acid modifications
	Modified residue	274	1	Cysteine methyl ester Potential
	Lipidation	269	1	S-palmitoyl cysteine Potential
	Lipidation	274	1	S-geranylgeranyl cysteine By similarity
Natural variations
	Natural variant	45	1	H → L. Corresponds to variant rs1180895 [ dbSNP | Ensembl ].		VAR_034435
Experimental info
	Sequence conflict	250	1	K → KR in AAL60514. Ref.2
	Sequence conflict	257	1	E → K in AAL60514. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8WXH6 [UniParc]. Last modified September 13, 2005. Version 2. Checksum: EB00BFF4E56A8577	FASTA	277	31,076
	10 20 30 40 50 60 MSAPGSPDQA YDFLLKFLLV GDRDVGKSEI LESLQDGAAE SPYSHLGGID YKTTTILLDG 70 80 90 100 110 120 QRVKLKLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFEGMDRWIK KIEEHAPGVP 130 140 150 160 170 180 KILVGNRLHL AFKRQVPREQ AQAYAERLGV TFFEVSPLCN FNIIESFTEL ARIVLLRHRM 190 200 210 220 230 240 NWLGRPSKVL SLQDLCCRTI VSCTPVHLVD KLPLPSTLRS HLKSFSMAKG LNARMMRGLS 250 260 270 YSLTTSSTHK SSLCKVEIVC PPQSPPKNCT RNSCKIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a new human cDNA homologous to Homo sapiens Rar protein." Zhou Y., Yu L., Zhao S.Y. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Kile B.T., Hilton D.J., Nicola N.A. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity." Itoh T., Satoh M., Kanno E., Fukuda M. Genes Cells 11:1023-1037(2006) [PubMed: 16923123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF132748 mRNA. Translation: AAL75949.1. AF422143 mRNA. Translation: AAL60514.1. AB232637 mRNA. Translation: BAF02899.1. Z69733 Genomic DNA. Translation: CAI41993.1. BC074854 mRNA. Translation: AAH74854.1. BC074855 mRNA. Translation: AAH74855.1. BC113501 mRNA. Translation: AAI13502.1. BC117232 mRNA. Translation: AAI17233.1.
IPI	IPI00514509.
RefSeq	NP_543155.2. NM_080879.2.
UniGene	Hs.27453. Hs.706904.
3D structure databases
ProteinModelPortal	Q8WXH6.
SMR	Q8WXH6. Positions 12-178.
ModBase	Search...
Polymorphism databases
DMDM	83287759.
Proteomic databases
PRIDE	Q8WXH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304236; ENSP00000305648; ENSG00000172476. ENST00000372633; ENSP00000361716; ENSG00000172476.
GeneID	142684.
KEGG	hsa:142684.
UCSC	uc004ekk.1. human.
Organism-specific databases
CTD	142684.
GeneCards	GC0XM102754.
H-InvDB	HIX0016949.
HGNC	HGNC:18283. RAB40A.
neXtProt	NX_Q8WXH6.
PharmGKB	PA34137.
GenAtlas	Search...
Phylogenomic databases
eggNOG	veNOG08219.
GeneTree	ENSGT00600000084072.
HOGENOM	HBG745225.
HOVERGEN	HBG009351.
InParanoid	Q8WXH6.
OMA	LLRHRMN.
OrthoDB	EOG40VVQ7.
PhylomeDB	Q8WXH6.
Gene expression databases
ArrayExpress	Q8WXH6.
Bgee	Q8WXH6.
CleanEx	HS_RAB40A.
Genevestigator	Q8WXH6.
GermOnline	ENSG00000172476. Homo sapiens.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. IPR001496. SOCS_C. [Graphical view]
KO	K07928.
Pfam	PF00071. Ras. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. SM00253. SOCS. 1 hit. SM00969. SOCS_box. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. Small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	84609.

Entry information

Entry name

RB40A_HUMAN

Accession

Primary (citable) accession number: Q8WXH6
Secondary accession number(s): O00407 , Q17RQ5, Q6DK06, Q8TF06

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.