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Protein

Ras-related protein Rab-40A

Gene

RAB40A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPBy similarity8
Nucleotide bindingi69 – 73GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719. RAB geranylgeranylation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-40A
Alternative name(s):
SOCS box-containing protein RAR2A
Short name:
Protein Rar-2
Gene namesi
Name:RAB40A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18283. RAB40A.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172476.
PharmGKBiPA34137.

Polymorphism and mutation databases

BioMutaiRAB40A.
DMDMi83287759.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212571 – 274Ras-related protein Rab-40AAdd BLAST274
PropeptideiPRO_0000370830275 – 277Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi269S-palmitoyl cysteineSequence analysis1
Modified residuei274Cysteine methyl esterSequence analysis1
Lipidationi274S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ8WXH6.
PRIDEiQ8WXH6.

PTM databases

iPTMnetiQ8WXH6.
PhosphoSitePlusiQ8WXH6.

Expressioni

Gene expression databases

BgeeiENSG00000172476.
CleanExiHS_RAB40A.
GenevisibleiQ8WXH6. HS.

Interactioni

Protein-protein interaction databases

BioGridi126773. 14 interactors.
IntActiQ8WXH6. 2 interactors.
MINTiMINT-6941746.
STRINGi9606.ENSP00000305648.

Structurei

3D structure databases

ProteinModelPortaliQ8WXH6.
SMRiQ8WXH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 228SOCS boxPROSITE-ProRule annotationAdd BLAST54

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0078. Eukaryota.
ENOG410XPUI. LUCA.
GeneTreeiENSGT00880000137976.
HOGENOMiHOG000233967.
HOVERGENiHBG009351.
InParanoidiQ8WXH6.
KOiK07928.
OMAiLRHRMNW.
OrthoDBiEOG091G0DGV.
PhylomeDBiQ8WXH6.
TreeFamiTF323230.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR001496. SOCS_box.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PF07525. SOCS_box. 1 hit.
SMARTiView protein in SMART
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.
PS50225. SOCS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WXH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPGSPDQA YDFLLKFLLV GDRDVGKSEI LESLQDGAAE SPYSHLGGID
60 70 80 90 100
YKTTTILLDG QRVKLKLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW
110 120 130 140 150
SFEGMDRWIK KIEEHAPGVP KILVGNRLHL AFKRQVPREQ AQAYAERLGV
160 170 180 190 200
TFFEVSPLCN FNIIESFTEL ARIVLLRHRM NWLGRPSKVL SLQDLCCRTI
210 220 230 240 250
VSCTPVHLVD KLPLPSTLRS HLKSFSMAKG LNARMMRGLS YSLTTSSTHK
260 270
SSLCKVEIVC PPQSPPKNCT RNSCKIS
Length:277
Mass (Da):31,076
Last modified:September 13, 2005 - v2
Checksum:iEB00BFF4E56A8577
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250K → KR in AAL60514 (Ref. 2) Curated1
Sequence conflicti257E → K in AAL60514 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03443545H → L. Corresponds to variant dbSNP:rs1180895Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132748 mRNA. Translation: AAL75949.1.
AF422143 mRNA. Translation: AAL60514.1.
AB232637 mRNA. Translation: BAF02899.1.
Z69733 Genomic DNA. No translation available.
BC074854 mRNA. Translation: AAH74854.1.
BC074855 mRNA. Translation: AAH74855.1.
BC113501 mRNA. Translation: AAI13502.1.
BC117232 mRNA. Translation: AAI17233.1.
CCDSiCCDS35357.1.
RefSeqiNP_543155.2. NM_080879.2.
XP_005262140.1. XM_005262083.4.
XP_011529174.1. XM_011530872.2.
UniGeneiHs.706904.

Genome annotation databases

EnsembliENST00000304236; ENSP00000305648; ENSG00000172476.
ENST00000372633; ENSP00000361716; ENSG00000172476.
GeneIDi142684.
KEGGihsa:142684.
UCSCiuc004ekk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRB40A_HUMAN
AccessioniPrimary (citable) accession number: Q8WXH6
Secondary accession number(s): O00407
, Q17RQ5, Q6DK06, Q8TF06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: September 13, 2005
Last modified: July 5, 2017
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families