Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8WXH5 (SOCS4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Suppressor of cytokine signaling 4

Short name=SOCS-4
Alternative name(s):
Suppressor of cytokine signaling 7
Short name=SOCS-7
Gene names
Name:SOCS4
Synonyms:SOCS7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. Ref.3 Ref.4

Pathway

Protein modification; protein ubiquitination.

Induction

Up-regulated by EGF. Ref.3

Domain

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.

Sequence similarities

Contains 1 SH2 domain.

Contains 1 SOCS box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440Suppressor of cytokine signaling 4
PRO_0000181247

Regions

Domain286 – 38196SH2
Domain376 – 42550SOCS box

Secondary structure

................................ 440
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8WXH5 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: A4A747AB7F6FF08C

FASTA44050,623
        10         20         30         40         50         60 
MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE TVNGIEKTEV 

        70         80         90        100        110        120 
SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR 

       130        140        150        160        170        180 
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPINSKSDE WVSTDLSQTE LRDGQLKRRN 

       190        200        210        220        230        240 
MEENINCFSH TNVQPCVITT DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS 

       250        260        270        280        290        300 
SRKRNKPKWD LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL 

       310        320        330        340        350        360 
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC VFHSPDITGL 

       370        380        390        400        410        420 
LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC TTYDGIDALP IPSSMKLYLK 

       430        440 
EYHYKSKVRV LRIDAPEQQC 

« Hide

References

« Hide 'large scale' references
[1]Hilton D.J., Alexander W.S., Nicola N.A.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[3]"Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling."
Kario E., Marmor M.D., Adamsky K., Citri A., Amit I., Amariglio N., Rechavi G., Yarden Y.
J. Biol. Chem. 280:7038-7048(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN EGF SIGNALING, INDUCTION BY EGF.
[4]"Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation."
Bullock A.N., Rodriguez M.C., Debreczeni J.E., Songyang Z., Knapp S.
Structure 15:1493-1504(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 274-437 IN COMPLEX WITH ELONGINS TCEB1 AND TCEB2, FUNCTION, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF424815 mRNA. Translation: AAL60517.1.
BC060790 mRNA. Translation: AAH60790.1.
CCDSCCDS9722.1.
RefSeqNP_543143.1. NM_080867.2.
NP_955453.1. NM_199421.1.
UniGeneHs.744302.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2IZVX-ray2.55A274-437[»]
ProteinModelPortalQ8WXH5.
SMRQ8WXH5. Positions 274-429.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125796. 7 interactions.
DIPDIP-29568N.
IntActQ8WXH5. 5 interactions.
MINTMINT-2835873.
STRING9606.ENSP00000341327.

PTM databases

PhosphoSiteQ8WXH5.

Polymorphism databases

DMDM20178106.

Proteomic databases

PaxDbQ8WXH5.
PRIDEQ8WXH5.

Protocols and materials databases

DNASU122809.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339298; ENSP00000341327; ENSG00000180008.
ENST00000395472; ENSP00000378855; ENSG00000180008.
ENST00000555846; ENSP00000452522; ENSG00000180008.
GeneID122809.
KEGGhsa:122809.
UCSCuc001xbo.3. human.

Organism-specific databases

CTD122809.
GeneCardsGC14P055493.
HGNCHGNC:19392. SOCS4.
HPACAB013478.
neXtProtNX_Q8WXH5.
PharmGKBPA164742477.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG258974.
HOGENOMHOG000027791.
HOVERGENHBG054138.
InParanoidQ8WXH5.
KOK04697.
OMAESCSDAE.
OrthoDBEOG7XH6QR.
PhylomeDBQ8WXH5.
TreeFamTF321368.

Enzyme and pathway databases

SignaLinkQ8WXH5.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ8WXH5.
BgeeQ8WXH5.
CleanExHS_SOCS4.
HS_SOCS7.
GenevestigatorQ8WXH5.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
IPR028413. SOCS.
IPR028416. SOCS4.
IPR022252. SOCS4/SOCS5_dom.
IPR001496. SOCS_C.
[Graphical view]
PANTHERPTHR10385. PTHR10385. 1 hit.
PTHR10385:SF29. PTHR10385:SF29. 1 hit.
PfamPF00017. SH2. 1 hit.
PF12610. SOCS. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8WXH5.
GenomeRNAi122809.
NextBio81007.
PROQ8WXH5.

Entry information

Entry nameSOCS4_HUMAN
AccessionPrimary (citable) accession number: Q8WXH5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM