Suppressor of cytokine signaling 4 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q8WXH5 (SOCS4_HUMAN)

Last modified January 19, 2010. Version 67. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Suppressor of cytokine signaling 4
      Short name=SOCS-4
Alternative name(s):
    Suppressor of cytokine signaling 7
      Short name=SOCS-7

Gene names

Name:	SOCS4
Synonyms:	SOCS7

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.
Sequence similarities	Contains 1 SH2 domain. Contains 1 SOCS box domain.

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Ontologies

Keywords
Biological process	Growth regulation Ubl conjugation pathway
Domain	SH2 domain
Molecular function	Signal transduction inhibitor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of signal transduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 440

440

Suppressor of cytokine signaling 4

PRO_0000181247

Regions

Domain

286 – 381

SH2

Domain

376 – 425

SOCS box

Secondary structure

440

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q8WXH5-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: A4A747AB7F6FF08C
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FASTA

440

50,623

        10         20         30         40         50         60 
MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE TVNGIEKTEV 

        70         80         90        100        110        120 
SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR 

       130        140        150        160        170        180 
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPINSKSDE WVSTDLSQTE LRDGQLKRRN 

       190        200        210        220        230        240 
MEENINCFSH TNVQPCVITT DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS 

       250        260        270        280        290        300 
SRKRNKPKWD LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL 

       310        320        330        340        350        360 
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC VFHSPDITGL 

       370        380        390        400        410        420 
LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC TTYDGIDALP IPSSMKLYLK 

       430        440 
EYHYKSKVRV LRIDAPEQQC

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Hilton D.J., Alexander W.S., Nicola N.A. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF424815 mRNA. Translation: AAL60517.1.
BC060790 mRNA. Translation: AAH60790.1.

IPI

IPI00103544.

RefSeq

NP_543143.1.
NP_955453.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2IZV	X-ray	2.55	A	274-437	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29568N.

STRING

Q8WXH5.

Proteomic databases

PRIDE

Q8WXH5.

Genome annotation databases

Ensembl

ENST00000339298; ENSP00000341327; ENSG00000180008; Homo sapiens. [Genome view]
ENST00000395472; ENSP00000378855; ENSG00000180008; Homo sapiens. [Genome view]

GeneID

122809.

KEGG

hsa:122809.

UCSC

uc001xbo.1. human.

Organism-specific databases

CTD

122809.

GeneCards

GC14P054563.

HGNC

HGNC:19392. SOCS4.

HPA

CAB013478.

PharmGKB

PA134919680.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG444599.

HOVERGEN

Q8WXH5.

InParanoid

Q8WXH5.

OMA

VWSGKKL.

OrthoDB

EOG96T5KR.

PhylomeDB

Q8WXH5.

Gene expression databases

ArrayExpress

Q8WXH5.

Bgee

Q8WXH5.

CleanEx

HS_SOCS4.
HS_SOCS7.

Genevestigator

Q8WXH5.

GermOnline

ENSG00000180008. Homo sapiens.

Family and domain databases

InterPro

IPR000980. SH2.
IPR001496. SOCS_C.
[Graphical view]

Gene3D

G3DSA:3.30.505.10. SH2. 1 hit.

Pfam

PF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]

SMART

SM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
[Graphical view]

PROSITE

PS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

81007.

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Entry information

Entry name

SOCS4_HUMAN

Accession

Primary (citable) accession number: Q8WXH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	March 1, 2002
Last modified:	January 19, 2010
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families