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Q8WXH5

- SOCS4_HUMAN

UniProt

Q8WXH5 - SOCS4_HUMAN

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Protein

Suppressor of cytokine signaling 4

Gene
SOCS4, SOCS7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.2 Publications

Pathwayi

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
  3. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: InterPro
  4. protein ubiquitination Source: UniProtKB-UniPathway
  5. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ8WXH5.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 4
Short name:
SOCS-4
Alternative name(s):
Suppressor of cytokine signaling 7
Short name:
SOCS-7
Gene namesi
Name:SOCS4
Synonyms:SOCS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19392. SOCS4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742477.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Suppressor of cytokine signaling 4PRO_0000181247Add
BLAST

Proteomic databases

PaxDbiQ8WXH5.
PRIDEiQ8WXH5.

PTM databases

PhosphoSiteiQ8WXH5.

Expressioni

Inductioni

Up-regulated by EGF.1 Publication

Gene expression databases

ArrayExpressiQ8WXH5.
BgeeiQ8WXH5.
CleanExiHS_SOCS4.
HS_SOCS7.
GenevestigatoriQ8WXH5.

Organism-specific databases

HPAiCAB013478.

Interactioni

Protein-protein interaction databases

BioGridi125796. 7 interactions.
DIPiDIP-29568N.
IntActiQ8WXH5. 5 interactions.
MINTiMINT-2835873.
STRINGi9606.ENSP00000341327.

Structurei

Secondary structure

1
440
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi278 – 2836
Beta strandi287 – 2904
Helixi293 – 3008
Beta strandi307 – 3126
Beta strandi319 – 3268
Beta strandi329 – 3346
Beta strandi336 – 3383
Beta strandi341 – 3444
Beta strandi354 – 3563
Helixi357 – 3637
Helixi367 – 3693
Helixi389 – 40012
Helixi403 – 4075
Beta strandi409 – 4113
Helixi413 – 4197
Beta strandi421 – 4266

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IZVX-ray2.55A274-437[»]
ProteinModelPortaliQ8WXH5.
SMRiQ8WXH5. Positions 274-429.

Miscellaneous databases

EvolutionaryTraceiQ8WXH5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini286 – 38196SH2Add
BLAST
Domaini376 – 42550SOCS boxAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SOCS box domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG258974.
HOGENOMiHOG000027791.
HOVERGENiHBG054138.
InParanoidiQ8WXH5.
KOiK04697.
OMAiESCSDAE.
OrthoDBiEOG7XH6QR.
PhylomeDBiQ8WXH5.
TreeFamiTF321368.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028413. SOCS.
IPR028416. SOCS4.
IPR022252. SOCS4/SOCS5_dom.
IPR001496. SOCS_C.
[Graphical view]
PANTHERiPTHR10385. PTHR10385. 1 hit.
PTHR10385:SF29. PTHR10385:SF29. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF12610. SOCS. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXH5-1 [UniParc]FASTAAdd to Basket

« Hide

MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE    50
TVNGIEKTEV SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG 100
QCFPIKNCSS RHSSGLPSKR KIHISELMLD KCPFPPRSDL AFRWHFIKRH 150
TAPINSKSDE WVSTDLSQTE LRDGQLKRRN MEENINCFSH TNVQPCVITT 200
DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS SRKRNKPKWD 250
LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL 300
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC 350
VFHSPDITGL LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC 400
TTYDGIDALP IPSSMKLYLK EYHYKSKVRV LRIDAPEQQC 440
Length:440
Mass (Da):50,623
Last modified:March 1, 2002 - v1
Checksum:iA4A747AB7F6FF08C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF424815 mRNA. Translation: AAL60517.1.
BC060790 mRNA. Translation: AAH60790.1.
CCDSiCCDS9722.1.
RefSeqiNP_543143.1. NM_080867.2.
NP_955453.1. NM_199421.1.
UniGeneiHs.744302.

Genome annotation databases

EnsembliENST00000339298; ENSP00000341327; ENSG00000180008.
ENST00000395472; ENSP00000378855; ENSG00000180008.
ENST00000555846; ENSP00000452522; ENSG00000180008.
GeneIDi122809.
KEGGihsa:122809.
UCSCiuc001xbo.3. human.

Polymorphism databases

DMDMi20178106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF424815 mRNA. Translation: AAL60517.1 .
BC060790 mRNA. Translation: AAH60790.1 .
CCDSi CCDS9722.1.
RefSeqi NP_543143.1. NM_080867.2.
NP_955453.1. NM_199421.1.
UniGenei Hs.744302.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2IZV X-ray 2.55 A 274-437 [» ]
ProteinModelPortali Q8WXH5.
SMRi Q8WXH5. Positions 274-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125796. 7 interactions.
DIPi DIP-29568N.
IntActi Q8WXH5. 5 interactions.
MINTi MINT-2835873.
STRINGi 9606.ENSP00000341327.

PTM databases

PhosphoSitei Q8WXH5.

Polymorphism databases

DMDMi 20178106.

Proteomic databases

PaxDbi Q8WXH5.
PRIDEi Q8WXH5.

Protocols and materials databases

DNASUi 122809.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339298 ; ENSP00000341327 ; ENSG00000180008 .
ENST00000395472 ; ENSP00000378855 ; ENSG00000180008 .
ENST00000555846 ; ENSP00000452522 ; ENSG00000180008 .
GeneIDi 122809.
KEGGi hsa:122809.
UCSCi uc001xbo.3. human.

Organism-specific databases

CTDi 122809.
GeneCardsi GC14P055493.
HGNCi HGNC:19392. SOCS4.
HPAi CAB013478.
neXtProti NX_Q8WXH5.
PharmGKBi PA164742477.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258974.
HOGENOMi HOG000027791.
HOVERGENi HBG054138.
InParanoidi Q8WXH5.
KOi K04697.
OMAi ESCSDAE.
OrthoDBi EOG7XH6QR.
PhylomeDBi Q8WXH5.
TreeFami TF321368.

Enzyme and pathway databases

UniPathwayi UPA00143 .
SignaLinki Q8WXH5.

Miscellaneous databases

EvolutionaryTracei Q8WXH5.
GenomeRNAii 122809.
NextBioi 81007.
PROi Q8WXH5.

Gene expression databases

ArrayExpressi Q8WXH5.
Bgeei Q8WXH5.
CleanExi HS_SOCS4.
HS_SOCS7.
Genevestigatori Q8WXH5.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR000980. SH2.
IPR028413. SOCS.
IPR028416. SOCS4.
IPR022252. SOCS4/SOCS5_dom.
IPR001496. SOCS_C.
[Graphical view ]
PANTHERi PTHR10385. PTHR10385. 1 hit.
PTHR10385:SF29. PTHR10385:SF29. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF12610. SOCS. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hilton D.J., Alexander W.S., Nicola N.A.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling."
    Kario E., Marmor M.D., Adamsky K., Citri A., Amit I., Amariglio N., Rechavi G., Yarden Y.
    J. Biol. Chem. 280:7038-7048(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EGF SIGNALING, INDUCTION BY EGF.
  4. "Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation."
    Bullock A.N., Rodriguez M.C., Debreczeni J.E., Songyang Z., Knapp S.
    Structure 15:1493-1504(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 274-437 IN COMPLEX WITH ELONGINS TCEB1 AND TCEB2, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiSOCS4_HUMAN
AccessioniPrimary (citable) accession number: Q8WXH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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