Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Suppressor of cytokine signaling 4

Gene

SOCS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.2 Publications

Pathway:iprotein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ8WXH5.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 4
Short name:
SOCS-4
Alternative name(s):
Suppressor of cytokine signaling 7
Short name:
SOCS-7
Gene namesi
Name:SOCS4
Synonyms:SOCS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19392. SOCS4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742477.

Polymorphism and mutation databases

BioMutaiSOCS4.
DMDMi20178106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Suppressor of cytokine signaling 4PRO_0000181247Add
BLAST

Proteomic databases

MaxQBiQ8WXH5.
PaxDbiQ8WXH5.
PRIDEiQ8WXH5.

PTM databases

PhosphoSiteiQ8WXH5.

Expressioni

Inductioni

Up-regulated by EGF.1 Publication

Gene expression databases

BgeeiQ8WXH5.
CleanExiHS_SOCS4.
HS_SOCS7.
ExpressionAtlasiQ8WXH5. baseline and differential.
GenevisibleiQ8WXH5. HS.

Organism-specific databases

HPAiCAB013478.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FRS3O435592EBI-3942425,EBI-725515
GRB2P629933EBI-3942425,EBI-401755
PIK3R3Q925693EBI-3942425,EBI-79893
PINK1Q9BXM73EBI-3942425,EBI-2846068
RBP7Q96R053EBI-3942425,EBI-2856326

Protein-protein interaction databases

BioGridi125796. 11 interactions.
DIPiDIP-29568N.
IntActiQ8WXH5. 14 interactions.
MINTiMINT-2835873.
STRINGi9606.ENSP00000341327.

Structurei

Secondary structure

1
440
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi278 – 2836Combined sources
Beta strandi287 – 2904Combined sources
Helixi293 – 3008Combined sources
Beta strandi307 – 3126Combined sources
Beta strandi319 – 3268Combined sources
Beta strandi329 – 3346Combined sources
Beta strandi336 – 3383Combined sources
Beta strandi341 – 3444Combined sources
Beta strandi354 – 3563Combined sources
Helixi357 – 3637Combined sources
Helixi367 – 3693Combined sources
Helixi389 – 40012Combined sources
Helixi403 – 4075Combined sources
Beta strandi409 – 4113Combined sources
Helixi413 – 4197Combined sources
Beta strandi421 – 4266Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IZVX-ray2.55A274-437[»]
ProteinModelPortaliQ8WXH5.
SMRiQ8WXH5. Positions 274-429.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WXH5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini286 – 38196SH2PROSITE-ProRule annotationAdd
BLAST
Domaini376 – 42550SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG258974.
GeneTreeiENSGT00760000119136.
HOGENOMiHOG000027791.
HOVERGENiHBG054138.
InParanoidiQ8WXH5.
KOiK04697.
OMAiESCSDAE.
OrthoDBiEOG7XH6QR.
PhylomeDBiQ8WXH5.
TreeFamiTF321368.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028413. SOCS.
IPR028416. SOCS4.
IPR022252. SOCS4/SOCS5_dom.
IPR001496. SOCS_C.
[Graphical view]
PANTHERiPTHR10385. PTHR10385. 1 hit.
PTHR10385:SF29. PTHR10385:SF29. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF12610. SOCS. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE
60 70 80 90 100
TVNGIEKTEV SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG
110 120 130 140 150
QCFPIKNCSS RHSSGLPSKR KIHISELMLD KCPFPPRSDL AFRWHFIKRH
160 170 180 190 200
TAPINSKSDE WVSTDLSQTE LRDGQLKRRN MEENINCFSH TNVQPCVITT
210 220 230 240 250
DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS SRKRNKPKWD
260 270 280 290 300
LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL
310 320 330 340 350
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC
360 370 380 390 400
VFHSPDITGL LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC
410 420 430 440
TTYDGIDALP IPSSMKLYLK EYHYKSKVRV LRIDAPEQQC
Length:440
Mass (Da):50,623
Last modified:March 1, 2002 - v1
Checksum:iA4A747AB7F6FF08C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424815 mRNA. Translation: AAL60517.1.
BC060790 mRNA. Translation: AAH60790.1.
CCDSiCCDS9722.1.
RefSeqiNP_543143.1. NM_080867.2.
NP_955453.1. NM_199421.1.
XP_011534727.1. XM_011536425.1.
XP_011534728.1. XM_011536426.1.
UniGeneiHs.744302.

Genome annotation databases

EnsembliENST00000339298; ENSP00000341327; ENSG00000180008.
ENST00000395472; ENSP00000378855; ENSG00000180008.
ENST00000555846; ENSP00000452522; ENSG00000180008.
GeneIDi122809.
KEGGihsa:122809.
UCSCiuc001xbo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424815 mRNA. Translation: AAL60517.1.
BC060790 mRNA. Translation: AAH60790.1.
CCDSiCCDS9722.1.
RefSeqiNP_543143.1. NM_080867.2.
NP_955453.1. NM_199421.1.
XP_011534727.1. XM_011536425.1.
XP_011534728.1. XM_011536426.1.
UniGeneiHs.744302.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IZVX-ray2.55A274-437[»]
ProteinModelPortaliQ8WXH5.
SMRiQ8WXH5. Positions 274-429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125796. 11 interactions.
DIPiDIP-29568N.
IntActiQ8WXH5. 14 interactions.
MINTiMINT-2835873.
STRINGi9606.ENSP00000341327.

PTM databases

PhosphoSiteiQ8WXH5.

Polymorphism and mutation databases

BioMutaiSOCS4.
DMDMi20178106.

Proteomic databases

MaxQBiQ8WXH5.
PaxDbiQ8WXH5.
PRIDEiQ8WXH5.

Protocols and materials databases

DNASUi122809.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339298; ENSP00000341327; ENSG00000180008.
ENST00000395472; ENSP00000378855; ENSG00000180008.
ENST00000555846; ENSP00000452522; ENSG00000180008.
GeneIDi122809.
KEGGihsa:122809.
UCSCiuc001xbo.3. human.

Organism-specific databases

CTDi122809.
GeneCardsiGC14P055493.
HGNCiHGNC:19392. SOCS4.
HPAiCAB013478.
MIMi616337. gene.
neXtProtiNX_Q8WXH5.
PharmGKBiPA164742477.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG258974.
GeneTreeiENSGT00760000119136.
HOGENOMiHOG000027791.
HOVERGENiHBG054138.
InParanoidiQ8WXH5.
KOiK04697.
OMAiESCSDAE.
OrthoDBiEOG7XH6QR.
PhylomeDBiQ8WXH5.
TreeFamiTF321368.

Enzyme and pathway databases

UniPathwayiUPA00143.
SignaLinkiQ8WXH5.

Miscellaneous databases

ChiTaRSiSOCS4. human.
EvolutionaryTraceiQ8WXH5.
GenomeRNAii122809.
NextBioi81007.
PROiQ8WXH5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WXH5.
CleanExiHS_SOCS4.
HS_SOCS7.
ExpressionAtlasiQ8WXH5. baseline and differential.
GenevisibleiQ8WXH5. HS.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028413. SOCS.
IPR028416. SOCS4.
IPR022252. SOCS4/SOCS5_dom.
IPR001496. SOCS_C.
[Graphical view]
PANTHERiPTHR10385. PTHR10385. 1 hit.
PTHR10385:SF29. PTHR10385:SF29. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF12610. SOCS. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hilton D.J., Alexander W.S., Nicola N.A.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling."
    Kario E., Marmor M.D., Adamsky K., Citri A., Amit I., Amariglio N., Rechavi G., Yarden Y.
    J. Biol. Chem. 280:7038-7048(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EGF SIGNALING, INDUCTION BY EGF.
  4. "Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation."
    Bullock A.N., Rodriguez M.C., Debreczeni J.E., Songyang Z., Knapp S.
    Structure 15:1493-1504(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 274-437 IN COMPLEX WITH ELONGINS TCEB1 AND TCEB2, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiSOCS4_HUMAN
AccessioniPrimary (citable) accession number: Q8WXH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.