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Q8WXH5

- SOCS4_HUMAN

UniProt

Q8WXH5 - SOCS4_HUMAN

Protein

Suppressor of cytokine signaling 4

Gene

SOCS4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.2 Publications

    Pathwayi

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
    3. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: InterPro
    4. protein ubiquitination Source: UniProtKB-UniPathway
    5. regulation of growth Source: UniProtKB-KW

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Keywords - Biological processi

    Growth regulation, Ubl conjugation pathway

    Enzyme and pathway databases

    SignaLinkiQ8WXH5.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Suppressor of cytokine signaling 4
    Short name:
    SOCS-4
    Alternative name(s):
    Suppressor of cytokine signaling 7
    Short name:
    SOCS-7
    Gene namesi
    Name:SOCS4
    Synonyms:SOCS7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19392. SOCS4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164742477.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440Suppressor of cytokine signaling 4PRO_0000181247Add
    BLAST

    Proteomic databases

    PaxDbiQ8WXH5.
    PRIDEiQ8WXH5.

    PTM databases

    PhosphoSiteiQ8WXH5.

    Expressioni

    Inductioni

    Up-regulated by EGF.1 Publication

    Gene expression databases

    ArrayExpressiQ8WXH5.
    BgeeiQ8WXH5.
    CleanExiHS_SOCS4.
    HS_SOCS7.
    GenevestigatoriQ8WXH5.

    Organism-specific databases

    HPAiCAB013478.

    Interactioni

    Protein-protein interaction databases

    BioGridi125796. 7 interactions.
    DIPiDIP-29568N.
    IntActiQ8WXH5. 5 interactions.
    MINTiMINT-2835873.
    STRINGi9606.ENSP00000341327.

    Structurei

    Secondary structure

    1
    440
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi278 – 2836
    Beta strandi287 – 2904
    Helixi293 – 3008
    Beta strandi307 – 3126
    Beta strandi319 – 3268
    Beta strandi329 – 3346
    Beta strandi336 – 3383
    Beta strandi341 – 3444
    Beta strandi354 – 3563
    Helixi357 – 3637
    Helixi367 – 3693
    Helixi389 – 40012
    Helixi403 – 4075
    Beta strandi409 – 4113
    Helixi413 – 4197
    Beta strandi421 – 4266

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IZVX-ray2.55A274-437[»]
    ProteinModelPortaliQ8WXH5.
    SMRiQ8WXH5. Positions 274-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WXH5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini286 – 38196SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini376 – 42550SOCS boxPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

    Sequence similaritiesi

    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SOCS box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG258974.
    HOGENOMiHOG000027791.
    HOVERGENiHBG054138.
    InParanoidiQ8WXH5.
    KOiK04697.
    OMAiESCSDAE.
    OrthoDBiEOG7XH6QR.
    PhylomeDBiQ8WXH5.
    TreeFamiTF321368.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    IPR028413. SOCS.
    IPR028416. SOCS4.
    IPR022252. SOCS4/SOCS5_dom.
    IPR001496. SOCS_C.
    [Graphical view]
    PANTHERiPTHR10385. PTHR10385. 1 hit.
    PTHR10385:SF29. PTHR10385:SF29. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF12610. SOCS. 1 hit.
    PF07525. SOCS_box. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00253. SOCS. 1 hit.
    SM00969. SOCS_box. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    PS50225. SOCS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WXH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE    50
    TVNGIEKTEV SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG 100
    QCFPIKNCSS RHSSGLPSKR KIHISELMLD KCPFPPRSDL AFRWHFIKRH 150
    TAPINSKSDE WVSTDLSQTE LRDGQLKRRN MEENINCFSH TNVQPCVITT 200
    DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS SRKRNKPKWD 250
    LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL 300
    EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC 350
    VFHSPDITGL LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC 400
    TTYDGIDALP IPSSMKLYLK EYHYKSKVRV LRIDAPEQQC 440
    Length:440
    Mass (Da):50,623
    Last modified:March 1, 2002 - v1
    Checksum:iA4A747AB7F6FF08C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF424815 mRNA. Translation: AAL60517.1.
    BC060790 mRNA. Translation: AAH60790.1.
    CCDSiCCDS9722.1.
    RefSeqiNP_543143.1. NM_080867.2.
    NP_955453.1. NM_199421.1.
    UniGeneiHs.744302.

    Genome annotation databases

    EnsembliENST00000339298; ENSP00000341327; ENSG00000180008.
    ENST00000395472; ENSP00000378855; ENSG00000180008.
    ENST00000555846; ENSP00000452522; ENSG00000180008.
    GeneIDi122809.
    KEGGihsa:122809.
    UCSCiuc001xbo.3. human.

    Polymorphism databases

    DMDMi20178106.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF424815 mRNA. Translation: AAL60517.1 .
    BC060790 mRNA. Translation: AAH60790.1 .
    CCDSi CCDS9722.1.
    RefSeqi NP_543143.1. NM_080867.2.
    NP_955453.1. NM_199421.1.
    UniGenei Hs.744302.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IZV X-ray 2.55 A 274-437 [» ]
    ProteinModelPortali Q8WXH5.
    SMRi Q8WXH5. Positions 274-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125796. 7 interactions.
    DIPi DIP-29568N.
    IntActi Q8WXH5. 5 interactions.
    MINTi MINT-2835873.
    STRINGi 9606.ENSP00000341327.

    PTM databases

    PhosphoSitei Q8WXH5.

    Polymorphism databases

    DMDMi 20178106.

    Proteomic databases

    PaxDbi Q8WXH5.
    PRIDEi Q8WXH5.

    Protocols and materials databases

    DNASUi 122809.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339298 ; ENSP00000341327 ; ENSG00000180008 .
    ENST00000395472 ; ENSP00000378855 ; ENSG00000180008 .
    ENST00000555846 ; ENSP00000452522 ; ENSG00000180008 .
    GeneIDi 122809.
    KEGGi hsa:122809.
    UCSCi uc001xbo.3. human.

    Organism-specific databases

    CTDi 122809.
    GeneCardsi GC14P055493.
    HGNCi HGNC:19392. SOCS4.
    HPAi CAB013478.
    neXtProti NX_Q8WXH5.
    PharmGKBi PA164742477.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258974.
    HOGENOMi HOG000027791.
    HOVERGENi HBG054138.
    InParanoidi Q8WXH5.
    KOi K04697.
    OMAi ESCSDAE.
    OrthoDBi EOG7XH6QR.
    PhylomeDBi Q8WXH5.
    TreeFami TF321368.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    SignaLinki Q8WXH5.

    Miscellaneous databases

    EvolutionaryTracei Q8WXH5.
    GenomeRNAii 122809.
    NextBioi 81007.
    PROi Q8WXH5.

    Gene expression databases

    ArrayExpressi Q8WXH5.
    Bgeei Q8WXH5.
    CleanExi HS_SOCS4.
    HS_SOCS7.
    Genevestigatori Q8WXH5.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    IPR028413. SOCS.
    IPR028416. SOCS4.
    IPR022252. SOCS4/SOCS5_dom.
    IPR001496. SOCS_C.
    [Graphical view ]
    PANTHERi PTHR10385. PTHR10385. 1 hit.
    PTHR10385:SF29. PTHR10385:SF29. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF12610. SOCS. 1 hit.
    PF07525. SOCS_box. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00253. SOCS. 1 hit.
    SM00969. SOCS_box. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    PS50225. SOCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hilton D.J., Alexander W.S., Nicola N.A.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling."
      Kario E., Marmor M.D., Adamsky K., Citri A., Amit I., Amariglio N., Rechavi G., Yarden Y.
      J. Biol. Chem. 280:7038-7048(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN EGF SIGNALING, INDUCTION BY EGF.
    4. "Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation."
      Bullock A.N., Rodriguez M.C., Debreczeni J.E., Songyang Z., Knapp S.
      Structure 15:1493-1504(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 274-437 IN COMPLEX WITH ELONGINS TCEB1 AND TCEB2, FUNCTION, SUBUNIT.

    Entry informationi

    Entry nameiSOCS4_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3