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Q8WXH4 (ASB11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat and SOCS box protein 11

Short name=ASB-11
Gene names
Name:ASB11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.

Pathway

Protein modification; protein ubiquitination.

Domain

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.

Sequence similarities

Contains 6 ANK repeats.

Contains 1 SOCS box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Inferred from electronic annotation. Source: InterPro

protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WXH4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WXH4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     88-104: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8WXH4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MEDGPVFYGF...IAEEIYGGIS → MLQLTGENEK...GDYICHTFQG
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Ankyrin repeat and SOCS box protein 11
PRO_0000066944

Regions

Repeat64 – 9330ANK 1
Repeat97 – 12630ANK 2
Repeat130 – 15930ANK 3
Repeat162 – 19130ANK 4
Repeat195 – 22430ANK 5
Repeat227 – 25630ANK 6
Domain273 – 32351SOCS box

Natural variations

Alternative sequence1 – 6060MEDGP…YGGIS → MLQLTGENEKNCEVSERIRR SGPWKEISFGDYICHTFQG in isoform 3.
VSP_047127
Alternative sequence88 – 10417Missing in isoform 2.
VSP_043087
Natural variant1651S → L. Ref.5
VAR_069428
Natural variant2491D → N.
Corresponds to variant rs34025595 [ dbSNP | Ensembl ].
VAR_048286
Natural variant2631S → G.
Corresponds to variant rs35859007 [ dbSNP | Ensembl ].
VAR_048287

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: F95A40184C5BBF4E

FASTA32335,367
        10         20         30         40         50         60 
MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR IAEEIYGGIS 

        70         80         90        100        110        120 
DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS SLHEACLGGH VACAKALLEN 

       130        140        150        160        170        180 
GAHVNGVTVH GATPLFNACC SGSAACVNVL LEFGAKAQLE VHLASPIHEA VKRGHRECME 

       190        200        210        220        230        240 
ILLANNVNID HEVPQLGTPL YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN 

       250        260        270        280        290        300 
VEVIHLLTDY GANLKRRNAQ GKSALDLAAP KSSVEQALLL REGPPALSQL CRLCVRKCLG 

       310        320 
RACHQAIHKL HLPEPLERFL LYQ 

« Hide

Isoform 2 [UniParc].

Checksum: 2C83F1E160D3AAD2
Show »

FASTA30633,534
Isoform 3 [UniParc].

Checksum: 0D33F8E4E0A400FB
Show »

FASTA30232,952

References

« Hide 'large scale' references
[1]"SOCS box proteins."
Kile B.T., Hilton D.J., Nicola N.A.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Liver.
[3]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Diagnostic exome sequencing in persons with severe intellectual disability."
de Ligt J., Willemsen M.H., van Bon B.W., Kleefstra T., Yntema H.G., Kroes T., Vulto-van Silfhout A.T., Koolen D.A., de Vries P., Gilissen C., del Rosario M., Hoischen A., Scheffer H., de Vries B.B., Brunner H.G., Veltman J.A., Vissers L.E.
N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LEU-165.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF425642 mRNA. Translation: AAL60519.1.
BX537857 mRNA. Translation: CAD97864.1.
AC095351 Genomic DNA. No translation available.
BC069340 mRNA. Translation: AAH69340.1.
BC103874 mRNA. Translation: AAI03875.1.
BC103875 mRNA. Translation: AAI03876.1.
CCDSCCDS14164.1. [Q8WXH4-1]
CCDS35209.1. [Q8WXH4-3]
CCDS56596.1. [Q8WXH4-2]
RefSeqNP_001012428.1. NM_001012428.2. [Q8WXH4-3]
NP_001188512.1. NM_001201583.1. [Q8WXH4-2]
NP_543149.1. NM_080873.2. [Q8WXH4-1]
XP_005274501.1. XM_005274444.2. [Q8WXH4-1]
XP_006724526.1. XM_006724463.1. [Q8WXH4-1]
XP_006724527.1. XM_006724464.1. [Q8WXH4-3]
UniGeneHs.352183.

3D structure databases

ProteinModelPortalQ8WXH4.
SMRQ8WXH4. Positions 18-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126610. 15 interactions.
STRING9606.ENSP00000417914.

Polymorphism databases

DMDM20531990.

Proteomic databases

PaxDbQ8WXH4.
PRIDEQ8WXH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344384; ENSP00000343408; ENSG00000165192. [Q8WXH4-3]
ENST00000380470; ENSP00000369837; ENSG00000165192. [Q8WXH4-2]
ENST00000480796; ENSP00000417914; ENSG00000165192. [Q8WXH4-1]
ENST00000537676; ENSP00000445465; ENSG00000165192. [Q8WXH4-3]
GeneID140456.
KEGGhsa:140456.
UCSCuc004cwp.2. human. [Q8WXH4-1]
uc010net.2. human. [Q8WXH4-2]

Organism-specific databases

CTD140456.
GeneCardsGC0XM015298.
HGNCHGNC:17186. ASB11.
HPAHPA000238.
MIM300626. gene.
neXtProtNX_Q8WXH4.
PharmGKBPA25029.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000231513.
HOVERGENHBG001376.
InParanoidQ8WXH4.
KOK10333.
OMAYGANLKC.
OrthoDBEOG7J447G.
PhylomeDBQ8WXH4.
TreeFamTF331945.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ8WXH4.
BgeeQ8WXH4.
CleanExHS_ASB11.
GenevestigatorQ8WXH4.

Family and domain databases

Gene3D1.25.40.20. 3 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi140456.
NextBio84099.
PROQ8WXH4.
SOURCESearch...

Entry information

Entry nameASB11_HUMAN
AccessionPrimary (citable) accession number: Q8WXH4
Secondary accession number(s): E9PEN1, Q3SYC4, Q7Z667
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM