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Protein

Ankyrin repeat and SOCS box protein 11

Gene

ASB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165192-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 11
Short name:
ASB-11
Gene namesi
Name:ASB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:17186. ASB11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165192.
PharmGKBiPA25029.

Polymorphism and mutation databases

BioMutaiASB11.
DMDMi20531990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669441 – 323Ankyrin repeat and SOCS box protein 11Add BLAST323

Proteomic databases

PaxDbiQ8WXH4.
PeptideAtlasiQ8WXH4.
PRIDEiQ8WXH4.

PTM databases

iPTMnetiQ8WXH4.
PhosphoSitePlusiQ8WXH4.

Expressioni

Gene expression databases

BgeeiENSG00000165192.
CleanExiHS_ASB11.
ExpressionAtlasiQ8WXH4. baseline and differential.
GenevisibleiQ8WXH4. HS.

Organism-specific databases

HPAiHPA000238.

Interactioni

Protein-protein interaction databases

BioGridi126610. 14 interactors.
STRINGi9606.ENSP00000417914.

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi68 – 75Combined sources8
Helixi78 – 87Combined sources10
Helixi101 – 107Combined sources7
Helixi111 – 119Combined sources9
Helixi134 – 141Combined sources8
Helixi144 – 152Combined sources9
Helixi166 – 172Combined sources7
Helixi176 – 184Combined sources9
Turni194 – 196Combined sources3
Helixi199 – 205Combined sources7
Helixi209 – 217Combined sources9
Helixi231 – 236Combined sources6
Helixi241 – 249Combined sources9
Helixi264 – 267Combined sources4
Helixi273 – 281Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UUCX-ray1.80A64-287[»]
ProteinModelPortaliQ8WXH4.
SMRiQ8WXH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 93ANK 1Add BLAST30
Repeati97 – 126ANK 2Add BLAST30
Repeati130 – 159ANK 3Add BLAST30
Repeati162 – 191ANK 4Add BLAST30
Repeati195 – 224ANK 5Add BLAST30
Repeati227 – 256ANK 6Add BLAST30
Domaini273 – 323SOCS boxPROSITE-ProRule annotationAdd BLAST51

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ8WXH4.
KOiK10333.
OMAiYICHTFQ.
OrthoDBiEOG091G0DYR.
PhylomeDBiQ8WXH4.
TreeFamiTF331945.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR
60 70 80 90 100
IAEEIYGGIS DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS
110 120 130 140 150
SLHEACLGGH VACAKALLEN GAHVNGVTVH GATPLFNACC SGSAACVNVL
160 170 180 190 200
LEFGAKAQLE VHLASPIHEA VKRGHRECME ILLANNVNID HEVPQLGTPL
210 220 230 240 250
YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN VEVIHLLTDY
260 270 280 290 300
GANLKRRNAQ GKSALDLAAP KSSVEQALLL REGPPALSQL CRLCVRKCLG
310 320
RACHQAIHKL HLPEPLERFL LYQ
Length:323
Mass (Da):35,367
Last modified:March 1, 2002 - v1
Checksum:iF95A40184C5BBF4E
GO
Isoform 2 (identifier: Q8WXH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-104: Missing.

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):33,534
Checksum:i2C83F1E160D3AAD2
GO
Isoform 3 (identifier: Q8WXH4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MEDGPVFYGF...IAEEIYGGIS → MLQLTGENEK...GDYICHTFQG

Note: Gene prediction based on EST data.
Show »
Length:302
Mass (Da):32,952
Checksum:i0D33F8E4E0A400FB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069428165S → L.1 PublicationCorresponds to variant rs144572145dbSNPEnsembl.1
Natural variantiVAR_048286249D → N.Corresponds to variant rs34025595dbSNPEnsembl.1
Natural variantiVAR_048287263S → G.Corresponds to variant rs35859007dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471271 – 60MEDGP…YGGIS → MLQLTGENEKNCEVSERIRR SGPWKEISFGDYICHTFQG in isoform 3. CuratedAdd BLAST60
Alternative sequenceiVSP_04308788 – 104Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF425642 mRNA. Translation: AAL60519.1.
BX537857 mRNA. Translation: CAD97864.1.
AC095351 Genomic DNA. No translation available.
BC069340 mRNA. Translation: AAH69340.1.
BC103874 mRNA. Translation: AAI03875.1.
BC103875 mRNA. Translation: AAI03876.1.
CCDSiCCDS14164.1. [Q8WXH4-1]
CCDS35209.1. [Q8WXH4-3]
CCDS56596.1. [Q8WXH4-2]
RefSeqiNP_001012428.1. NM_001012428.2. [Q8WXH4-3]
NP_001188512.1. NM_001201583.1. [Q8WXH4-2]
NP_543149.1. NM_080873.2. [Q8WXH4-1]
UniGeneiHs.352183.

Genome annotation databases

EnsembliENST00000344384; ENSP00000343408; ENSG00000165192. [Q8WXH4-3]
ENST00000380470; ENSP00000369837; ENSG00000165192. [Q8WXH4-2]
ENST00000480796; ENSP00000417914; ENSG00000165192. [Q8WXH4-1]
GeneIDi140456.
KEGGihsa:140456.
UCSCiuc004cwo.3. human. [Q8WXH4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF425642 mRNA. Translation: AAL60519.1.
BX537857 mRNA. Translation: CAD97864.1.
AC095351 Genomic DNA. No translation available.
BC069340 mRNA. Translation: AAH69340.1.
BC103874 mRNA. Translation: AAI03875.1.
BC103875 mRNA. Translation: AAI03876.1.
CCDSiCCDS14164.1. [Q8WXH4-1]
CCDS35209.1. [Q8WXH4-3]
CCDS56596.1. [Q8WXH4-2]
RefSeqiNP_001012428.1. NM_001012428.2. [Q8WXH4-3]
NP_001188512.1. NM_001201583.1. [Q8WXH4-2]
NP_543149.1. NM_080873.2. [Q8WXH4-1]
UniGeneiHs.352183.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UUCX-ray1.80A64-287[»]
ProteinModelPortaliQ8WXH4.
SMRiQ8WXH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126610. 14 interactors.
STRINGi9606.ENSP00000417914.

PTM databases

iPTMnetiQ8WXH4.
PhosphoSitePlusiQ8WXH4.

Polymorphism and mutation databases

BioMutaiASB11.
DMDMi20531990.

Proteomic databases

PaxDbiQ8WXH4.
PeptideAtlasiQ8WXH4.
PRIDEiQ8WXH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344384; ENSP00000343408; ENSG00000165192. [Q8WXH4-3]
ENST00000380470; ENSP00000369837; ENSG00000165192. [Q8WXH4-2]
ENST00000480796; ENSP00000417914; ENSG00000165192. [Q8WXH4-1]
GeneIDi140456.
KEGGihsa:140456.
UCSCiuc004cwo.3. human. [Q8WXH4-1]

Organism-specific databases

CTDi140456.
GeneCardsiASB11.
HGNCiHGNC:17186. ASB11.
HPAiHPA000238.
MIMi300626. gene.
neXtProtiNX_Q8WXH4.
OpenTargetsiENSG00000165192.
PharmGKBiPA25029.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ8WXH4.
KOiK10333.
OMAiYICHTFQ.
OrthoDBiEOG091G0DYR.
PhylomeDBiQ8WXH4.
TreeFamiTF331945.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000165192-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii140456.
PROiQ8WXH4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165192.
CleanExiHS_ASB11.
ExpressionAtlasiQ8WXH4. baseline and differential.
GenevisibleiQ8WXH4. HS.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB11_HUMAN
AccessioniPrimary (citable) accession number: Q8WXH4
Secondary accession number(s): E9PEN1, Q3SYC4, Q7Z667
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.