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Q8WXH4

- ASB11_HUMAN

UniProt

Q8WXH4 - ASB11_HUMAN

Protein

Ankyrin repeat and SOCS box protein 11

Gene

ASB11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

    Pathwayi

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat and SOCS box protein 11
    Short name:
    ASB-11
    Gene namesi
    Name:ASB11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:17186. ASB11.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25029.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Ankyrin repeat and SOCS box protein 11PRO_0000066944Add
    BLAST

    Proteomic databases

    PaxDbiQ8WXH4.
    PRIDEiQ8WXH4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WXH4.
    BgeeiQ8WXH4.
    CleanExiHS_ASB11.
    GenevestigatoriQ8WXH4.

    Organism-specific databases

    HPAiHPA000238.

    Interactioni

    Protein-protein interaction databases

    BioGridi126610. 15 interactions.
    STRINGi9606.ENSP00000417914.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXH4.
    SMRiQ8WXH4. Positions 18-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati64 – 9330ANK 1Add
    BLAST
    Repeati97 – 12630ANK 2Add
    BLAST
    Repeati130 – 15930ANK 3Add
    BLAST
    Repeati162 – 19130ANK 4Add
    BLAST
    Repeati195 – 22430ANK 5Add
    BLAST
    Repeati227 – 25630ANK 6Add
    BLAST
    Domaini273 – 32351SOCS boxPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

    Sequence similaritiesi

    Contains 6 ANK repeats.PROSITE-ProRule annotation
    Contains 1 SOCS box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000231513.
    HOVERGENiHBG001376.
    InParanoidiQ8WXH4.
    KOiK10333.
    OMAiYGANLKC.
    OrthoDBiEOG7J447G.
    PhylomeDBiQ8WXH4.
    TreeFamiTF331945.

    Family and domain databases

    Gene3Di1.25.40.20. 3 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001496. SOCS_C.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    PF07525. SOCS_box. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 6 hits.
    SM00969. SOCS_box. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 6 hits.
    PS50225. SOCS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WXH4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR    50
    IAEEIYGGIS DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS 100
    SLHEACLGGH VACAKALLEN GAHVNGVTVH GATPLFNACC SGSAACVNVL 150
    LEFGAKAQLE VHLASPIHEA VKRGHRECME ILLANNVNID HEVPQLGTPL 200
    YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN VEVIHLLTDY 250
    GANLKRRNAQ GKSALDLAAP KSSVEQALLL REGPPALSQL CRLCVRKCLG 300
    RACHQAIHKL HLPEPLERFL LYQ 323
    Length:323
    Mass (Da):35,367
    Last modified:March 1, 2002 - v1
    Checksum:iF95A40184C5BBF4E
    GO
    Isoform 2 (identifier: Q8WXH4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         88-104: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:306
    Mass (Da):33,534
    Checksum:i2C83F1E160D3AAD2
    GO
    Isoform 3 (identifier: Q8WXH4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: MEDGPVFYGF...IAEEIYGGIS → MLQLTGENEK...GDYICHTFQG

    Note: Gene prediction based on EST data.

    Show »
    Length:302
    Mass (Da):32,952
    Checksum:i0D33F8E4E0A400FB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti165 – 1651S → L.1 Publication
    VAR_069428
    Natural varianti249 – 2491D → N.
    Corresponds to variant rs34025595 [ dbSNP | Ensembl ].
    VAR_048286
    Natural varianti263 – 2631S → G.
    Corresponds to variant rs35859007 [ dbSNP | Ensembl ].
    VAR_048287

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6060MEDGP…YGGIS → MLQLTGENEKNCEVSERIRR SGPWKEISFGDYICHTFQG in isoform 3. CuratedVSP_047127Add
    BLAST
    Alternative sequencei88 – 10417Missing in isoform 2. 1 PublicationVSP_043087Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF425642 mRNA. Translation: AAL60519.1.
    BX537857 mRNA. Translation: CAD97864.1.
    AC095351 Genomic DNA. No translation available.
    BC069340 mRNA. Translation: AAH69340.1.
    BC103874 mRNA. Translation: AAI03875.1.
    BC103875 mRNA. Translation: AAI03876.1.
    CCDSiCCDS14164.1. [Q8WXH4-1]
    CCDS35209.1. [Q8WXH4-3]
    CCDS56596.1. [Q8WXH4-2]
    RefSeqiNP_001012428.1. NM_001012428.2. [Q8WXH4-3]
    NP_001188512.1. NM_001201583.1. [Q8WXH4-2]
    NP_543149.1. NM_080873.2. [Q8WXH4-1]
    XP_005274501.1. XM_005274444.2. [Q8WXH4-1]
    XP_006724526.1. XM_006724463.1. [Q8WXH4-1]
    XP_006724527.1. XM_006724464.1. [Q8WXH4-3]
    UniGeneiHs.352183.

    Genome annotation databases

    EnsembliENST00000344384; ENSP00000343408; ENSG00000165192. [Q8WXH4-3]
    ENST00000380470; ENSP00000369837; ENSG00000165192. [Q8WXH4-2]
    ENST00000480796; ENSP00000417914; ENSG00000165192. [Q8WXH4-1]
    GeneIDi140456.
    KEGGihsa:140456.
    UCSCiuc004cwp.2. human. [Q8WXH4-1]
    uc010net.2. human. [Q8WXH4-2]

    Polymorphism databases

    DMDMi20531990.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF425642 mRNA. Translation: AAL60519.1 .
    BX537857 mRNA. Translation: CAD97864.1 .
    AC095351 Genomic DNA. No translation available.
    BC069340 mRNA. Translation: AAH69340.1 .
    BC103874 mRNA. Translation: AAI03875.1 .
    BC103875 mRNA. Translation: AAI03876.1 .
    CCDSi CCDS14164.1. [Q8WXH4-1 ]
    CCDS35209.1. [Q8WXH4-3 ]
    CCDS56596.1. [Q8WXH4-2 ]
    RefSeqi NP_001012428.1. NM_001012428.2. [Q8WXH4-3 ]
    NP_001188512.1. NM_001201583.1. [Q8WXH4-2 ]
    NP_543149.1. NM_080873.2. [Q8WXH4-1 ]
    XP_005274501.1. XM_005274444.2. [Q8WXH4-1 ]
    XP_006724526.1. XM_006724463.1. [Q8WXH4-1 ]
    XP_006724527.1. XM_006724464.1. [Q8WXH4-3 ]
    UniGenei Hs.352183.

    3D structure databases

    ProteinModelPortali Q8WXH4.
    SMRi Q8WXH4. Positions 18-322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126610. 15 interactions.
    STRINGi 9606.ENSP00000417914.

    Polymorphism databases

    DMDMi 20531990.

    Proteomic databases

    PaxDbi Q8WXH4.
    PRIDEi Q8WXH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344384 ; ENSP00000343408 ; ENSG00000165192 . [Q8WXH4-3 ]
    ENST00000380470 ; ENSP00000369837 ; ENSG00000165192 . [Q8WXH4-2 ]
    ENST00000480796 ; ENSP00000417914 ; ENSG00000165192 . [Q8WXH4-1 ]
    GeneIDi 140456.
    KEGGi hsa:140456.
    UCSCi uc004cwp.2. human. [Q8WXH4-1 ]
    uc010net.2. human. [Q8WXH4-2 ]

    Organism-specific databases

    CTDi 140456.
    GeneCardsi GC0XM015298.
    HGNCi HGNC:17186. ASB11.
    HPAi HPA000238.
    MIMi 300626. gene.
    neXtProti NX_Q8WXH4.
    PharmGKBi PA25029.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000231513.
    HOVERGENi HBG001376.
    InParanoidi Q8WXH4.
    KOi K10333.
    OMAi YGANLKC.
    OrthoDBi EOG7J447G.
    PhylomeDBi Q8WXH4.
    TreeFami TF331945.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    GenomeRNAii 140456.
    NextBioi 84099.
    PROi Q8WXH4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WXH4.
    Bgeei Q8WXH4.
    CleanExi HS_ASB11.
    Genevestigatori Q8WXH4.

    Family and domain databases

    Gene3Di 1.25.40.20. 3 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001496. SOCS_C.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    PF07525. SOCS_box. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 6 hits.
    SM00969. SOCS_box. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 6 hits.
    PS50225. SOCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SOCS box proteins."
      Kile B.T., Hilton D.J., Nicola N.A.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Liver.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. Cited for: VARIANT LEU-165.

    Entry informationi

    Entry nameiASB11_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXH4
    Secondary accession number(s): E9PEN1, Q3SYC4, Q7Z667
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3