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Protein

Ankyrin repeat and SOCS box protein 11

Gene

ASB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 11
Short name:
ASB-11
Gene namesi
Name:ASB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:17186. ASB11.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25029.

Polymorphism and mutation databases

BioMutaiASB11.
DMDMi20531990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Ankyrin repeat and SOCS box protein 11PRO_0000066944Add
BLAST

Proteomic databases

PaxDbiQ8WXH4.
PRIDEiQ8WXH4.

Expressioni

Gene expression databases

BgeeiQ8WXH4.
CleanExiHS_ASB11.
ExpressionAtlasiQ8WXH4. baseline.
GenevestigatoriQ8WXH4.

Organism-specific databases

HPAiHPA000238.

Interactioni

Protein-protein interaction databases

BioGridi126610. 14 interactions.
STRINGi9606.ENSP00000417914.

Structurei

Secondary structure

1
323
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi68 – 758Combined sources
Helixi78 – 8710Combined sources
Helixi101 – 1077Combined sources
Helixi111 – 1199Combined sources
Helixi134 – 1418Combined sources
Helixi144 – 1529Combined sources
Helixi166 – 1727Combined sources
Helixi176 – 1849Combined sources
Turni194 – 1963Combined sources
Helixi199 – 2057Combined sources
Helixi209 – 2179Combined sources
Helixi231 – 2366Combined sources
Helixi241 – 2499Combined sources
Helixi264 – 2674Combined sources
Helixi273 – 2819Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UUCX-ray1.80A64-287[»]
ProteinModelPortaliQ8WXH4.
SMRiQ8WXH4. Positions 35-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 9330ANK 1Add
BLAST
Repeati97 – 12630ANK 2Add
BLAST
Repeati130 – 15930ANK 3Add
BLAST
Repeati162 – 19130ANK 4Add
BLAST
Repeati195 – 22430ANK 5Add
BLAST
Repeati227 – 25630ANK 6Add
BLAST
Domaini273 – 32351SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ8WXH4.
KOiK10333.
OMAiNCEVSER.
OrthoDBiEOG7J447G.
PhylomeDBiQ8WXH4.
TreeFamiTF331945.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR
60 70 80 90 100
IAEEIYGGIS DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS
110 120 130 140 150
SLHEACLGGH VACAKALLEN GAHVNGVTVH GATPLFNACC SGSAACVNVL
160 170 180 190 200
LEFGAKAQLE VHLASPIHEA VKRGHRECME ILLANNVNID HEVPQLGTPL
210 220 230 240 250
YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN VEVIHLLTDY
260 270 280 290 300
GANLKRRNAQ GKSALDLAAP KSSVEQALLL REGPPALSQL CRLCVRKCLG
310 320
RACHQAIHKL HLPEPLERFL LYQ
Length:323
Mass (Da):35,367
Last modified:March 1, 2002 - v1
Checksum:iF95A40184C5BBF4E
GO
Isoform 2 (identifier: Q8WXH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-104: Missing.

Note: No experimental confirmation available.

Show »
Length:306
Mass (Da):33,534
Checksum:i2C83F1E160D3AAD2
GO
Isoform 3 (identifier: Q8WXH4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MEDGPVFYGF...IAEEIYGGIS → MLQLTGENEK...GDYICHTFQG

Note: Gene prediction based on EST data.

Show »
Length:302
Mass (Da):32,952
Checksum:i0D33F8E4E0A400FB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti165 – 1651S → L.1 Publication
VAR_069428
Natural varianti249 – 2491D → N.
Corresponds to variant rs34025595 [ dbSNP | Ensembl ].
VAR_048286
Natural varianti263 – 2631S → G.
Corresponds to variant rs35859007 [ dbSNP | Ensembl ].
VAR_048287

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6060MEDGP…YGGIS → MLQLTGENEKNCEVSERIRR SGPWKEISFGDYICHTFQG in isoform 3. CuratedVSP_047127Add
BLAST
Alternative sequencei88 – 10417Missing in isoform 2. 1 PublicationVSP_043087Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF425642 mRNA. Translation: AAL60519.1.
BX537857 mRNA. Translation: CAD97864.1.
AC095351 Genomic DNA. No translation available.
BC069340 mRNA. Translation: AAH69340.1.
BC103874 mRNA. Translation: AAI03875.1.
BC103875 mRNA. Translation: AAI03876.1.
CCDSiCCDS14164.1. [Q8WXH4-1]
CCDS35209.1. [Q8WXH4-3]
CCDS56596.1. [Q8WXH4-2]
RefSeqiNP_001012428.1. NM_001012428.2. [Q8WXH4-3]
NP_001188512.1. NM_001201583.1. [Q8WXH4-2]
NP_543149.1. NM_080873.2. [Q8WXH4-1]
XP_005274501.1. XM_005274444.3. [Q8WXH4-1]
XP_006724526.1. XM_006724463.2. [Q8WXH4-1]
UniGeneiHs.352183.

Genome annotation databases

EnsembliENST00000344384; ENSP00000343408; ENSG00000165192. [Q8WXH4-3]
ENST00000380470; ENSP00000369837; ENSG00000165192. [Q8WXH4-2]
ENST00000480796; ENSP00000417914; ENSG00000165192. [Q8WXH4-1]
GeneIDi140456.
KEGGihsa:140456.
UCSCiuc004cwo.2. human.
uc004cwp.2. human. [Q8WXH4-1]
uc010net.2. human. [Q8WXH4-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF425642 mRNA. Translation: AAL60519.1.
BX537857 mRNA. Translation: CAD97864.1.
AC095351 Genomic DNA. No translation available.
BC069340 mRNA. Translation: AAH69340.1.
BC103874 mRNA. Translation: AAI03875.1.
BC103875 mRNA. Translation: AAI03876.1.
CCDSiCCDS14164.1. [Q8WXH4-1]
CCDS35209.1. [Q8WXH4-3]
CCDS56596.1. [Q8WXH4-2]
RefSeqiNP_001012428.1. NM_001012428.2. [Q8WXH4-3]
NP_001188512.1. NM_001201583.1. [Q8WXH4-2]
NP_543149.1. NM_080873.2. [Q8WXH4-1]
XP_005274501.1. XM_005274444.3. [Q8WXH4-1]
XP_006724526.1. XM_006724463.2. [Q8WXH4-1]
UniGeneiHs.352183.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UUCX-ray1.80A64-287[»]
ProteinModelPortaliQ8WXH4.
SMRiQ8WXH4. Positions 35-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126610. 14 interactions.
STRINGi9606.ENSP00000417914.

Polymorphism and mutation databases

BioMutaiASB11.
DMDMi20531990.

Proteomic databases

PaxDbiQ8WXH4.
PRIDEiQ8WXH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344384; ENSP00000343408; ENSG00000165192. [Q8WXH4-3]
ENST00000380470; ENSP00000369837; ENSG00000165192. [Q8WXH4-2]
ENST00000480796; ENSP00000417914; ENSG00000165192. [Q8WXH4-1]
GeneIDi140456.
KEGGihsa:140456.
UCSCiuc004cwo.2. human.
uc004cwp.2. human. [Q8WXH4-1]
uc010net.2. human. [Q8WXH4-2]

Organism-specific databases

CTDi140456.
GeneCardsiGC0XM015298.
HGNCiHGNC:17186. ASB11.
HPAiHPA000238.
MIMi300626. gene.
neXtProtiNX_Q8WXH4.
PharmGKBiPA25029.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ8WXH4.
KOiK10333.
OMAiNCEVSER.
OrthoDBiEOG7J447G.
PhylomeDBiQ8WXH4.
TreeFamiTF331945.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii140456.
NextBioi84099.
PROiQ8WXH4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WXH4.
CleanExiHS_ASB11.
ExpressionAtlasiQ8WXH4. baseline.
GenevestigatoriQ8WXH4.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SOCS box proteins."
    Kile B.T., Hilton D.J., Nicola N.A.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: VARIANT LEU-165.

Entry informationi

Entry nameiASB11_HUMAN
AccessioniPrimary (citable) accession number: Q8WXH4
Secondary accession number(s): E9PEN1, Q3SYC4, Q7Z667
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: April 29, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.