Reviewed, UniProtKB/Swiss-Prot Q8WXH4 (ASB11_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat and SOCS box protein 11
      Short name=ASB-11

Gene names

Name:

ASB11

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.
Sequence similarities	Contains 6 ANK repeats. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Ankyrin repeat and SOCS box protein 11		PRO_0000066944
Regions
	Repeat	64 – 93	30	ANK 1
	Repeat	97 – 126	30	ANK 2
	Repeat	130 – 159	30	ANK 3
	Repeat	162 – 191	30	ANK 4
	Repeat	195 – 224	30	ANK 5
	Repeat	227 – 256	30	ANK 6
	Domain	273 – 323	51	SOCS box
Natural variations
	Natural variant	249	1	D → N: dbSNP rs34025595.		VAR_048286
	Natural variant	263	1	S → G: dbSNP rs35859007.		VAR_048287

Sequences

	Sequence		Length	Mass (Da)
	Q8WXH4-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F95A40184C5BBF4E	FASTA	323	35,367
	10 20 30 40 50 60 MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR IAEEIYGGIS 70 80 90 100 110 120 DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS SLHEACLGGH VACAKALLEN 130 140 150 160 170 180 GAHVNGVTVH GATPLFNACC SGSAACVNVL LEFGAKAQLE VHLASPIHEA VKRGHRECME 190 200 210 220 230 240 ILLANNVNID HEVPQLGTPL YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN 250 260 270 280 290 300 VEVIHLLTDY GANLKRRNAQ GKSALDLAAP KSSVEQALLL REGPPALSQL CRLCVRKCLG 310 320 RACHQAIHKL HLPEPLERFL LYQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SOCS box proteins." Kile B.T., Hilton D.J., Nicola N.A. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF425642 mRNA. Translation: AAL60519.1. BC069340 mRNA. Translation: AAH69340.1. BC103874 mRNA. Translation: AAI03875.1. BC103875 mRNA. Translation: AAI03876.1.
IPI	IPI00103543.
RefSeq	NP_001012428.1. NP_543149.1.
UniGene	Hs.352183
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WXH4.
Proteomic databases
PRIDE	Q8WXH4.
Genome annotation databases
Ensembl	ENST00000480796; ENSP00000417914; ENSG00000165192; Homo sapiens. [Genome view]
GeneID	140456.
KEGG	hsa:140456.
UCSC	uc004cwp.1. human.
Organism-specific databases
CTD	140456.
GeneCards	GC0XM015211.
HGNC	HGNC:17186. ASB11.
HPA	HPA000238.
MIM	300626. gene.
PharmGKB	PA25029.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8WXH4.
HOVERGEN	Q8WXH4.
OrthoDB	EOG9MKR1K
Gene expression databases
ArrayExpress	Q8WXH4.
Bgee	Q8WXH4.
CleanEx	HS_ASB11.
Genevestigator	Q8WXH4.
GermOnline	ENSG00000165192. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001496. SOCS_C. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 6 hits. PF07525. SOCS_box. 1 hit. [Graphical view]
SMART	SM00248. ANK. 6 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 6 hits. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	84099.
SOURCE	Search...

Entry information

Entry name

ASB11_HUMAN

Accession

Primary (citable) accession number: Q8WXH4
Secondary accession number(s): Q3SYC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	March 1, 2002
Last modified:	November 24, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.