Q8WXH4 (ASB11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat and SOCS box protein 11
Short name=ASB-11

Gene names

Name:

ASB11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.
Sequence similarities	Contains 6 ANK repeats. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Ankyrin repeat and SOCS box protein 11		PRO_0000066944
Regions
	Repeat	64 – 93	30	ANK 1
	Repeat	97 – 126	30	ANK 2
	Repeat	130 – 159	30	ANK 3
	Repeat	162 – 191	30	ANK 4
	Repeat	195 – 224	30	ANK 5
	Repeat	227 – 256	30	ANK 6
	Domain	273 – 323	51	SOCS box
Natural variations
	Natural variant	249	1	D → N. Corresponds to variant rs34025595 [ dbSNP | Ensembl ].		VAR_048286
	Natural variant	263	1	S → G. Corresponds to variant rs35859007 [ dbSNP | Ensembl ].		VAR_048287

Sequences

	Sequence		Length	Mass (Da)
	Q8WXH4 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F95A40184C5BBF4E	FASTA	323	35,367
	10 20 30 40 50 60 MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR IAEEIYGGIS 70 80 90 100 110 120 DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS SLHEACLGGH VACAKALLEN 130 140 150 160 170 180 GAHVNGVTVH GATPLFNACC SGSAACVNVL LEFGAKAQLE VHLASPIHEA VKRGHRECME 190 200 210 220 230 240 ILLANNVNID HEVPQLGTPL YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN 250 260 270 280 290 300 VEVIHLLTDY GANLKRRNAQ GKSALDLAAP KSSVEQALLL REGPPALSQL CRLCVRKCLG 310 320 RACHQAIHKL HLPEPLERFL LYQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SOCS box proteins." Kile B.T., Hilton D.J., Nicola N.A. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF425642 mRNA. Translation: AAL60519.1. BC069340 mRNA. Translation: AAH69340.1. BC103874 mRNA. Translation: AAI03875.1. BC103875 mRNA. Translation: AAI03876.1.
IPI	IPI00103543.
RefSeq	NP_001012428.1. NM_001012428.2. NP_543149.1. NM_080873.2.
UniGene	Hs.352183.
3D structure databases
ProteinModelPortal	Q8WXH4.
SMR	Q8WXH4. Positions 17-322.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WXH4.
Polymorphism databases
DMDM	20531990.
Proteomic databases
PRIDE	Q8WXH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000480796; ENSP00000417914; ENSG00000165192.
GeneID	140456.
KEGG	hsa:140456.
UCSC	uc004cwp.1. human.
Organism-specific databases
CTD	140456.
GeneCards	GC0XM015211.
HGNC	HGNC:17186. ASB11.
HPA	HPA000238.
MIM	300626. gene.
neXtProt	NX_Q8WXH4.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19239.
GeneTree	ENSGT00550000074326.
HOGENOM	HBG505676.
HOVERGEN	HBG001376.
InParanoid	Q8WXH4.
PhylomeDB	Q8WXH4.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q8WXH4.
Bgee	Q8WXH4.
CleanEx	HS_ASB11.
Genevestigator	Q8WXH4.
GermOnline	ENSG00000165192. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001496. SOCS_C. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
KO	K10333.
Pfam	PF12796. Ank_2. 2 hits. PF07525. SOCS_box. 1 hit. [Graphical view]
SMART	SM00248. ANK. 6 hits. SM00969. SOCS_box. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 6 hits. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	84099.
SOURCE	Search...

Entry information

Entry name

ASB11_HUMAN

Accession

Primary (citable) accession number: Q8WXH4
Secondary accession number(s): Q3SYC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.