Q8WXH0 (SYNE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nesprin-2

Alternative name(s):
Nuclear envelope spectrin repeat protein 2
Nucleus and actin connecting element protein
Short name=Protein NUANCE
Synaptic nuclear envelope protein 2
Short name=Syne-2

Gene names

Name:	SYNE2
Synonyms:	KIAA1011, NUA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	6885 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for centrosome migration to the apical cell surface during early ciliogenesis. Ref.1 Ref.14 Ref.16 Ref.21
Subunit structure	Component of LINC complexes composed of SUN domain-containing proteins SUN1 or SUN2 coupled to KASH domain-containing proteins (SYNE1, SYNE2 or SYNE3), also called nesprins. Interacts with F-actin via its N-terminal domain. Interacts with EMD, LMNA and MKS3. Ref.1 Ref.13 Ref.14 Ref.16 Ref.19
Subcellular location	Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side Potential. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein Potential. Cell membrane; Single-pass membrane protein Potential. Cytoplasm › cytoskeleton. Mitochondrion. Nucleus › nucleoplasm. Note: Different isoform patterns are found in the different compartments of the cell. The isoforms having the C-terminal transmembrane span can be found in several organellar membranes like the nuclear envelope, the sarcoplasmic reticulum of myoblasts, or the lamellipodia and focal adhesions at the cell membrane. The largest part of the outer nuclear membrane-associated protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells. Shorter solubles isoforms can be found in the cytoplasm and within the nucleus. Ref.12 Ref.13 Ref.16
Tissue specificity	Widely expressed, with higher level in kidney, adult and fetal liver, stomach and placenta. Weakly expressed in skeletal muscle and brain. Isoform 5 is highly expressed in pancreas, skeletal muscle and heart. Ref.13
Domain	The KASH domain mediates the nuclear envelope targeting. Ref.14
Involvement in disease	Emery-Dreifuss muscular dystrophy 5 (EDMD5) [MIM:612999]: A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.25
Sequence similarities	Belongs to the nesprin family. Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 1 KASH domain. Contains 9 spectrin repeats.
Sequence caution	The sequence BAB84881.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAB45729.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAB55905.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane Mitochondrion Nucleus Sarcoplasmic reticulum
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Emery-Dreifuss muscular dystrophy
Domain	Coiled coil Repeat Transmembrane Transmembrane helix
Ligand	Actin-binding
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	centrosome localization Inferred from mutant phenotype Ref.21. Source: UniProtKB cytoskeletal anchoring at nuclear membrane Inferred from direct assay Ref.14. Source: UniProtKB establishment or maintenance of cell polarity Inferred from electronic annotation. Source: Compara fibroblast migration Inferred from electronic annotation. Source: Compara nuclear envelope organization Inferred from electronic annotation. Source: Compara nuclear migration along microfilament Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB protein localization to nucleus Inferred from electronic annotation. Source: Compara
Cellular_component	SUN-KASH complex Inferred from direct assay Ref.14. Source: UniProtKB Z disc Inferred from direct assay Ref.13. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell filopodium membrane Inferred from direct assay Ref.13. Source: UniProtKB focal adhesion Inferred from direct assay Ref.13. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW lamellipodium membrane Inferred from direct assay Ref.13. Source: UniProtKB mitochondrial part Inferred from direct assay Ref.13. Source: UniProtKB nuclear lumen Inferred from direct assay Ref.13. Source: UniProtKB nuclear membrane Inferred from direct assay. Source: HPA nuclear outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell sarcoplasmic reticulum Inferred from direct assay Ref.13. Source: UniProtKB sarcoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	actin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
APPL1	Q9UKG1	3	EBI-2372294,EBI-741243
SUN1	O94901	2	EBI-6170976,EBI-2796904
SUN2	Q9UH99	5	EBI-2372294,EBI-1044964

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WXH0-1)

Also known as: Nesprin-2 Giant; NUANCE;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WXH0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     6444-6444: S → SDVEIPENPEAYLKMTTKTLKASS
     6801-6801: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8WXH0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6030: Missing.

Note: Produced by exon skipping that results in a frameshift. No experimental confirmation available.

Isoform 4 (identifier: Q8WXH0-4)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-6122: Missing.

Isoform 5 (identifier: Q8WXH0-5)

Also known as: Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     1-6366: Missing.
     6444-6444: S → SDVEIPENPEAYLKMTTKTLKASS
     6664-6664: Q → QGSKTRPRSDVLFFK

Isoform 6 (identifier: Q8WXH0-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6469: Missing.
     6664-6664: Q → QGSKTRPRSDVLFFK
     6801-6801: Missing.

Isoform 7 (identifier: Q8WXH0-7)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-3638: Missing.
     3828-3828: Q → QDSKCFRSGPRPNIYVSYYVTVIQ

Isoform 8 (identifier: Q8WXH0-8)

The sequence of this isoform differs from the canonical sequence as follows:
     263-285: DVDVVDPDEKSIMTYVAQFLQYS → DAWRSSALYRIYMPGTVSCASYL
     286-6885: Missing.

Note: No experimental confirmation available.

Isoform 9 (identifier: Q8WXH0-9)

Also known as: NUANCE-N-33;

The sequence of this isoform differs from the canonical sequence as follows:
     263-267: DVDVV → AYKNF
     268-6885: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 6885

6885

Nesprin-2

PRO_0000163592

Regions

Topological domain

1 – 6834

6834

Cytoplasmic Potential

Transmembrane

6835 – 6855

21

Helical; Anchor for type IV membrane protein; Potential

Topological domain

6856 – 6885

30

Perinuclear space Potential

Domain

1 – 286

286

Actin-binding

Domain

31 – 136

106

CH 1

Domain

181 – 286

106

CH 2

Repeat

4944 – 5053

110

Spectrin 1

Repeat

5054 – 5167

114

Spectrin 2

Repeat

5170 – 5274

105

Spectrin 3

Repeat

5852 – 5914

63

Spectrin 4

Repeat

5917 – 6019

103

Spectrin 5

Repeat

6022 – 6133

112

Spectrin 6

Repeat

6136 – 6242

107

Spectrin 7

Repeat

6245 – 6349

105

Spectrin 8

Repeat

6551 – 6658

108

Spectrin 9

Domain

6826 – 6885

60

KASH

Coiled coil

233 – 255

23

Potential

Coiled coil

306 – 323

18

Potential

Coiled coil

461 – 477

17

Potential

Coiled coil

810 – 909

100

Potential

Coiled coil

941 – 972

32

Potential

Coiled coil

1008 – 1041

34

Potential

Coiled coil

1194 – 1222

29

Potential

Coiled coil

1299 – 1332

34

Potential

Coiled coil

1462 – 1494

33

Potential

Coiled coil

1566 – 1602

37

Potential

Coiled coil

1658 – 1708

51

Potential

Coiled coil

1747 – 1771

25

Potential

Coiled coil

1782 – 1804

23

Potential

Coiled coil

1923 – 1965

43

Potential

Coiled coil

2007 – 2035

29

Potential

Coiled coil

2176 – 2205

30

Potential

Coiled coil

2282 – 2369

88

Potential

Coiled coil

2422 – 2478

57

Potential

Coiled coil

2589 – 2650

62

Potential

Coiled coil

2696 – 2717

22

Potential

Coiled coil

2802 – 2835

34

Potential

Coiled coil

2866 – 2975

110

Potential

Coiled coil

3014 – 3057

44

Potential

Coiled coil

3087 – 3132

46

Potential

Coiled coil

3207 – 3241

35

Potential

Coiled coil

3297 – 3428

132

Potential

Coiled coil

3464 – 3505

42

Potential

Coiled coil

3553 – 3584

32

Potential

Coiled coil

3655 – 3723

69

Potential

Coiled coil

3778 – 3799

22

Potential

Coiled coil

3853 – 3911

59

Potential

Coiled coil

3971 – 4069

99

Potential

Coiled coil

4272 – 4299

28

Potential

Coiled coil

4307 – 4339

33

Potential

Coiled coil

4493 – 4536

44

Potential

Coiled coil

4636 – 4701

66

Potential

Coiled coil

4831 – 4861

31

Potential

Coiled coil

4911 – 4944

34

Potential

Coiled coil

5308 – 5346

39

Potential

Coiled coil

5428 – 5445

18

Potential

Coiled coil

5505 – 5529

25

Potential

Coiled coil

6697 – 6770

74

Potential

Amino acid modifications

Modified residue

955

1

N6-acetyllysine Ref.18

Modified residue

2781

1

Phosphoserine Ref.20 Ref.23

Modified residue

4108

1

Phosphoserine Ref.15 Ref.17

Modified residue

6361

1

Phosphoserine Ref.20

Natural variations

Alternative sequence

1 – 6469

6469

Missing in isoform 6.

VSP_007158

Alternative sequence

1 – 6366

6366

Missing in isoform 5.

VSP_007157

Alternative sequence

1 – 6122

6122

Missing in isoform 4.

VSP_007156

Alternative sequence

1 – 6030

6030

Missing in isoform 3.

VSP_007155

Alternative sequence

1 – 3638

3638

Missing in isoform 7.

VSP_007154

Alternative sequence

263 – 285

23

DVDVV…FLQYS → DAWRSSALYRIYMPGTVSCA SYL in isoform 8.

VSP_007161

Alternative sequence

263 – 267

5

DVDVV → AYKNF in isoform 9.

VSP_007159

Alternative sequence

268 – 6885

6618

Missing in isoform 9.

VSP_007160

Alternative sequence

286 – 6885

6600

Missing in isoform 8.

VSP_007162

Alternative sequence

3828

1

Q → QDSKCFRSGPRPNIYVSYYV TVIQ in isoform 7.

VSP_007163

Alternative sequence

6444

1

S → SDVEIPENPEAYLKMTTKTL KASS in isoform 2 and isoform 5.

VSP_007164

Alternative sequence

6664

1

Q → QGSKTRPRSDVLFFK in isoform 5 and isoform 6.

VSP_007165

Alternative sequence

6801

1

Missing in isoform 2 and isoform 6.

VSP_007166

Natural variant

8

1

P → S.
Corresponds to variant rs2275017 [ dbSNP | Ensembl ].

VAR_027947

Natural variant

432

1

S → R.
Corresponds to variant rs35554503 [ dbSNP | Ensembl ].

VAR_050238

Natural variant

574

1

I → T.
Corresponds to variant rs9944035 [ dbSNP | Ensembl ].

VAR_027948

Natural variant

1393

1

R → W.
Corresponds to variant rs17751301 [ dbSNP | Ensembl ].

VAR_050239

Natural variant

1969

1

M → T. Ref.1
Corresponds to variant rs4902264 [ dbSNP | Ensembl ].

VAR_050240

Natural variant

2284

1

A → V. Ref.1
Corresponds to variant rs4027402 [ dbSNP | Ensembl ].

VAR_050241

Natural variant

2347

1

A → E.
Corresponds to variant rs34625768 [ dbSNP | Ensembl ].

VAR_050242

Natural variant

2358

1

N → S.
Corresponds to variant rs4027404 [ dbSNP | Ensembl ].

VAR_027949

Natural variant

2359

1

S → G.
Corresponds to variant rs7157465 [ dbSNP | Ensembl ].

VAR_050243

Natural variant

2359

1

S → N. Ref.1
Corresponds to variant rs4027404 [ dbSNP | Ensembl ].

VAR_050244

Natural variant

2394

1

A → T.
Corresponds to variant rs4027405 [ dbSNP | Ensembl ].

VAR_027950

Natural variant

2395

1

A → T. Ref.1
Corresponds to variant rs4027405 [ dbSNP | Ensembl ].

VAR_050245

Natural variant

2490

1

V → G.
Corresponds to variant rs34393543 [ dbSNP | Ensembl ].

VAR_050246

Natural variant

2564

1

I → V.
Corresponds to variant rs11628107 [ dbSNP | Ensembl ].

VAR_050247

Natural variant

2801

1

G → S.
Corresponds to variant rs1890908 [ dbSNP | Ensembl ].

VAR_027951

Natural variant

2802

1

S → G. Ref.1
Corresponds to variant rs1890908 [ dbSNP | Ensembl ].

VAR_050248

Natural variant

2942

1

I → V. Ref.1
Corresponds to variant rs3829767 [ dbSNP | Ensembl ].

VAR_050249

Natural variant

3026

1

E → D.
Corresponds to variant rs34843668 [ dbSNP | Ensembl ].

VAR_050250

Natural variant

3130

1

N → S.
Corresponds to variant rs11847087 [ dbSNP | Ensembl ].

VAR_050251

Natural variant

3253

1

D → H. Ref.1
Corresponds to variant rs8010911 [ dbSNP | Ensembl ].

VAR_050252

Natural variant

3309

1

H → R. Ref.1
Corresponds to variant rs8010699 [ dbSNP | Ensembl ].

VAR_050253

Natural variant

3523

1

K → Q.
Corresponds to variant rs35203186 [ dbSNP | Ensembl ].

VAR_050254

Natural variant

3982

1

N → H.
Corresponds to variant rs10137972 [ dbSNP | Ensembl ].

VAR_050255

Natural variant

4041

1

R → H.
Corresponds to variant rs17101661 [ dbSNP | Ensembl ].

VAR_050256

Natural variant

4912

1

P → A.
Corresponds to variant rs17766354 [ dbSNP | Ensembl ].

VAR_050257

Natural variant

4913

1

E → K.
Corresponds to variant rs12881815 [ dbSNP | Ensembl ].

VAR_050258

Natural variant

5086

1

H → Y.
Corresponds to variant rs2039475 [ dbSNP | Ensembl ].

VAR_050259

Natural variant

5186

1

L → M. Ref.1 Ref.7
Corresponds to variant rs10151658 [ dbSNP | Ensembl ].

VAR_050260

Natural variant

5547

1

D → N.
Corresponds to variant rs17179194 [ dbSNP | Ensembl ].

VAR_050261

Natural variant

5940

1

V → I in a breast cancer sample; somatic mutation. Ref.24

VAR_036255

Natural variant

6155

1

A → V.
Corresponds to variant rs2275014 [ dbSNP | Ensembl ].

VAR_050262

Natural variant

6200

1

Y → C in a breast cancer sample; somatic mutation. Ref.24

VAR_036256

Natural variant

6211

1

T → M in EDMD5. Ref.25

VAR_062977

Natural variant

6681

1

K → E.
Corresponds to variant rs35315070 [ dbSNP | Ensembl ].

VAR_050263

Natural variant

6697

1

R → W.
Corresponds to variant rs35700578 [ dbSNP | Ensembl ].

VAR_050264

Experimental info

Sequence conflict

668

1

Missing Ref.3

Sequence conflict

1087

1

M → T Ref.3

Sequence conflict

3115

1

F → S in AAL33548. Ref.1

Sequence conflict

3193

1

E → G in AAL33548. Ref.1

Sequence conflict

3951

1

Q → L in AAL33802. Ref.2

Sequence conflict

4001

1

W → Q in AAN60443. Ref.3

Sequence conflict

4158

1

S → F in AAL33802. Ref.2

Sequence conflict

4158

1

S → F Ref.3

Sequence conflict

4209

1

I → T in AAL33802. Ref.2

Sequence conflict

4209

1

I → T Ref.3

Sequence conflict

4327

1

E → Q in AAL33802. Ref.2

Sequence conflict

4327

1

E → Q Ref.3

Sequence conflict

4418

1

N → K in AAL33802. Ref.2

Sequence conflict

4418

1

N → K Ref.3

Sequence conflict

4713

1

E → G in AAL33548. Ref.1

Sequence conflict

4733

1

P → S in AAL33802. Ref.2

Sequence conflict

4733

1

P → S Ref.3

Sequence conflict

4807

1

N → I in AAL33802. Ref.2

Sequence conflict

4807

1

N → I Ref.3

Sequence conflict

4826

1

S → P in AAL33802. Ref.2

Sequence conflict

4826

1

S → P Ref.3

Sequence conflict

5166

1

E → D in AAL33802. Ref.2

Sequence conflict

5166

1

E → D Ref.3

Sequence conflict

5646

1

T → A in AAL33802. Ref.2

Sequence conflict

5646

1

T → A Ref.3

Sequence conflict

5727

1

K → R in AAL33802. Ref.2

Sequence conflict

5727

1

K → R Ref.3

Secondary structure

1

.

.

.

.

.

.

6885

Helix Strand Turn

Details...

Turn

6867 – 6870

4

Beta strand

6871 – 6873

3

Beta strand

6875 – 6881

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Nesprin-2 Giant) (NUANCE) [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 3D37E27B080ADBD8	FASTA	6,885	796,442
	10 20 30 40 50 60 MASSPELPTE DEQGSWGIDD LHISLQAEQE DTQKKAFTCW INSQLARHTS PSVISDLFTD 70 80 90 100 110 120 IKKGHVLLDL LEVLSGQQLP RDKGSNTFQC RINIEHALTF LRNRSIKLIN IHVTDIIDGN 130 140 150 160 170 180 PSIILGLIWT IILHFHIEKL AQTLSCNYNQ PSLDDVSVVD SSPASSPPAK KCSKVQARWQ 190 200 210 220 230 240 MSARKALLLW AQEQCATYES VNVTDFKSSW RNGMAFLAII HALRPDLIDM KSVKHRSNKD 250 260 270 280 290 300 NLREAFRIAE QELKIPRLLE PEDVDVVDPD EKSIMTYVAQ FLQYSKDAPG TGEEAQGKVK 310 320 330 340 350 360 DAMGWLTLQK EKLQKLLKDS ENDTYFKKYN SLLSFMESFN EEKKSFLDVL SIKRDLDELD 370 380 390 400 410 420 KDHLQLREAW DGLDHQINAW KIKLNYALPP PLHQTEAWLQ EVEELMDEDL SASQDHSQAV 430 440 450 460 470 480 TLIQEKMTLF KSLMDRFEHH SNILLTFENK DENHLPLVPP NKLEEMKRRI NNILEKKFIL 490 500 510 520 530 540 LLEFHYYKCL VLGLVDEVKS KLDIWNIKYG SRESVELLLE DWHKFIEEKE FLARLDTSFQ 550 560 570 580 590 600 KCGEIYKNLA GECQNINKQY MMVKSDVCMY RKNIYNVKST LQKVLACWAT YVENLRLLRA 610 620 630 640 650 660 CFEETKKEEI KEVPFETLAQ WNLEHATLNE AGNFLVEVSN DVVGSSISKE LRRLNKRWRK 670 680 690 700 710 720 LVSKTQLEMN LPLMIKKQDQ PTFDNSGNIL SKEEKATVEF STDMSVELPE NYNQNIKAGE 730 740 750 760 770 780 KHEKENEEFT GQLKVAKDVE KLIGQVEIWE AEAKSVLDQD DVDTSMEESL KHLIAKGSMF 790 800 810 820 830 840 DELMARSEDM LQMDIQNISS QESFQHVLTT GLQAKIQEAK EKVQINVVKL IAALKNLTDV 850 860 870 880 890 900 SPDLDIRLKM EESQKELESY MMRAQQLLGQ RESPGELISK HKEALIISNT KSLAKYLKAV 910 920 930 940 950 960 EELKNNVTED IKMSLEEKSR DVCAKWESLH HELSLYVQQL KIDIEKGKLS DNILKLEKQI 970 980 990 1000 1010 1020 NKEKKLIRRG RTKGLIKEHE ACFSEEGCLY QLNHHMEVLR ELCEELPSQK SQQEVKRLLK 1030 1040 1050 1060 1070 1080 DYEQKIERLL KCASEIHMTL QPTAGGTSKN EGTITTSENR GGDPHSEAPF AKSDNQPSTE 1090 1100 1110 1120 1130 1140 KAMEPTMKFS LASVLRPLQE ESIMEKDYSA SINSLLERYD TYRDILEHHL QNNKFRITSD 1150 1160 1170 1180 1190 1200 FSSEEDRSSS CLQAKLTDLQ VIKNETDARW KEFEIISLKL ENHVNDIKKP FVIKERDTLK 1210 1220 1230 1240 1250 1260 ERERELQMTL NTRMESLETA LRLVLPVEKA SLLLCGSDLP LHKMAIQGFH LIDADRIYQH 1270 1280 1290 1300 1310 1320 LRNIQDSIAK QIEICNRLEE PGNFVLKELH PFDLHAMQNI ILKYKTQFEG MNHRVQRSED 1330 1340 1350 1360 1370 1380 TLKALEDFLA SLRTAKLSAE PVTDLSASDT QVAQENTLTV KNKEGEIHLM KDKAKHLDKC 1390 1400 1410 1420 1430 1440 LKMLDMSFKD AERGDDTSCE NLLDAFSIKL SETHGYGVQE EFTEENKLLE ACIFKNNELL 1450 1460 1470 1480 1490 1500 KNIQDVQSQI SKIGLKDPTV PAVKHRKKSL IRLDKVLDEY EEEKRHLQEM ANSLPHFKDG 1510 1520 1530 1540 1550 1560 REKTVNQQCQ NTVVLWENTK ALVTECLEQC GRVLELLKQY QNFKSILTTL IQKEESVISL 1570 1580 1590 1600 1610 1620 QASYMGKENL KKRIAEIEIV KEEFNEHLEV VDKINQVCKN LQFYLNKMKT FEEPPFEKEA 1630 1640 1650 1660 1670 1680 NIIVDRWLDI NEKTEDYYEN LGRALALWDK LFNLKNVIDE WTEKALQKME LHQLTEEDRE 1690 1700 1710 1720 1730 1740 RLKEELQVHE QKTSEFSRRV AEIQFLLQSS EIPLELQVME SSILNKMEHV QKCLTGESNC 1750 1760 1770 1780 1790 1800 HALSGSTAEL REDLDQAKTQ IGMTESLLKA LSPSDSLEIF TKLEEIQQQI LQQKHSMILL 1810 1820 1830 1840 1850 1860 ENQIGCLTPE LSELKKQYES VSDLFNTKKS VLQDHFSKLL NDQCKNFNDW FSNIKVNLKE 1870 1880 1890 1900 1910 1920 CFESSETKKS VEQKLQKLSD FLTLEGRNSK IKQVDSVLKH VKKHLPKAHV KELISWLVGQ 1930 1940 1950 1960 1970 1980 EFELEKMESI CQARAKELED SLQQLLRLQD DHRNLRKWLT NQEEKWKGME EPGEKTELFC 1990 2000 2010 2020 2030 2040 QALARKREQF ESVAQLNNSL KEYGFTEEEE IIMEATCLMD RYQTLLRQLS EIEEEDKLLP 2050 2060 2070 2080 2090 2100 TEDQSFNDLA HDVIHWIKEI KESLMVLNSS EGKMPLEERI QKIKEIILLK PEGDARIETI 2110 2120 2130 2140 2150 2160 MKQAESSEAP LVQKTLTDIS NQWDNTLHLA STYLSHQEKL LLEGEKYLQS KEDLRLMLIE 2170 2180 2190 2200 2210 2220 LKKKQEAGFA LQHGLQEKKA QLKIYKKFLK KAQDLTSLLK ELKSQGNYLL ECTKNPSFSE 2230 2240 2250 2260 2270 2280 EPWLEIKHLH ESLLQQLQDS VQNLDGHVRE HDSYQVCVTD LNTTLDNFSK EFVSFSDKPV 2290 2300 2310 2320 2330 2340 DQIAVEEKLQ KLQELENRLS LQDGTLKKIL ALAKSVKQNT SSVGQKIIKD DIKSLQCKQK 2350 2360 2370 2380 2390 2400 DLENRLASAK QEMECCLNSI LKSKRSTEKK GKFTLPGREK QATSDVQEST QESAAVEKLE 2410 2420 2430 2440 2450 2460 EDWEINKDSA VEMAMSKQLS LNAQESMKNT EDERKVNELQ NQPLELDTML RNEQLEEIEK 2470 2480 2490 2500 2510 2520 LYTQLEAKKA AIKPLEQTEC LNKTETGALV LHNIGYSAQH LDNLLQALIT LKKNKESQYC 2530 2540 2550 2560 2570 2580 VLRDFQEYLA AVESSMKALL TDKESLKVGP LDSVTYLDKI KKFIASIEKE KDSLGNLKIK 2590 2600 2610 2620 2630 2640 WENLSNHVTD MDKKLLESQI KQLEHGWEQV EQQIQKKYSQ QVVEYDEFTT LMNKVQDTEI 2650 2660 2670 2680 2690 2700 SLQQQQQHLQ LRLKSPEERA GNQSMIALTT DLQATKHGFS VLKGQAELQM KRIWGEKEKK 2710 2720 2730 2740 2750 2760 NLEDGINNLK KQWETLEPLH LEAENQIKKC DIRNKMKETI LWAKNLLGEL NPSIPLLPDD 2770 2780 2790 2800 2810 2820 ILSQIRKCKV THDGILARQQ SVESLAEEVK DKVPSLTTYE GSDLNNTLED LRNQYQMLVL 2830 2840 2850 2860 2870 2880 KSTQRSQQLE FKLEERSNFF AIIRKFQLMV QESETLIIPR VETAATEAEL KHHHVTLEAS 2890 2900 2910 2920 2930 2940 QKELQEIDSG ISTHLQELTN IYEELNVFER LFLEDQLKNL KIRTNRIQRF IQNTCNEVEH 2950 2960 2970 2980 2990 3000 KIKFCRQFHE KTSALQEEAD SIQRNELLLN QEVNKGVKEE IYNLKDRLTA IKCCILQVLK 3010 3020 3030 3040 3050 3060 LKKVFDYIGL NWDFSQLDQL QTQVFEKEKE LEEKIKQLDT FEEEHGKYQA LLSKMRAIDL 3070 3080 3090 3100 3110 3120 QIKKMTEVVL KAPDSSPESR RLNAQILSQR IEKAKCLCDE IIKKLNENKT FDDSFKEKEI 3130 3140 3150 3160 3170 3180 LQIKLNAEEN DKLYKVLQNM VLELSPKELD EKNCQDKLET SLHVLNQIKS QLQQPLLINL 3190 3200 3210 3220 3230 3240 EIKHIQNEKD NCEAFQEQVW AEMCSIKAVT AIEKQREENS SEASDVETKL REFEDLQMQL 3250 3260 3270 3280 3290 3300 NTSIDLRTNV LNDAYENLTR YKEAVTRAVE SITSLEAIII PYRVDVGNPE ESLEMPLRKQ 3310 3320 3330 3340 3350 3360 EELESTVAHI QDLTEKLGMI SSPEAKLQLQ YTLQELVSKN SAMKEAFKAQ ETEAERYLEN 3370 3380 3390 3400 3410 3420 YKCYRKMEED IYTNLSKMET VLGQSMSSLP LSYREALERL EQSKALVSNL ISTKEELMKL 3430 3440 3450 3460 3470 3480 RQILRLLRLR CTENDGICLL KIVSALWEKW LSLLEAAKEW EMWCEELKQE WKFVSEEIER 3490 3500 3510 3520 3530 3540 EAIILDNLQE ELPEISKTKE AATTEELSEL LDCLCQYGEN VEKQQLLLTL LLQRIRSIQN 3550 3560 3570 3580 3590 3600 VPESSGAVET VPAFQEITSM KERCNKLLQK VQKNKELVQT EIQERHSFTK EIIALKNFFQ 3610 3620 3630 3640 3650 3660 QTTTSFQNMA FQDHPEKSEQ FEELQSILKK GKLTFENIME KLRIKYSEMY TIVPAEIESQ 3670 3680 3690 3700 3710 3720 VEECRKALED IDEKISNEVL KSSPSYAMRR KIEEINNGLH NVEKMLQQKS KNIEKAQEIQ 3730 3740 3750 3760 3770 3780 KKMWDELDLW HSKLNELDSE VQDIVEQDPG QAQEWMDNLM IPFQQYQQVS QRAECRTSQL 3790 3800 3810 3820 3830 3840 NKATVKMEEY SDLLKSTEAW IENTSHLLAN PADYDSLRTL SHHASTVQMA LEDSEQKHNL 3850 3860 3870 3880 3890 3900 LHSIFMDLED LSIIFETDEL TQSIQELSNQ VTALQQKIME SLPQIQRMAD DVVAIESEVK 3910 3920 3930 3940 3950 3960 SMEKRVSKIK TILLSKEIFD FSPEEHLKHG EVILENIRPM KKTIAEIVSY QVELRLPQTG 3970 3980 3990 4000 4010 4020 MKPLPVFQRT NQLLQDIKLL ENVTQEQNEL LKVVIKQTNE WDEEIENLKQ ILNNYSAQFS 4030 4040 4050 4060 4070 4080 LEHMSPDQAD KLPQLQGEIE RMEKQILSLN QRKEDLLVDL KATVLNLHQH LKQEQEGVER 4090 4100 4110 4120 4130 4140 DRLPAVTSEE GGVAERDASE RKLNRRGSMS YLAAVEEEVE ESSVKSDNGD EKAEPSPQSW 4150 4160 4170 4180 4190 4200 SSLWKHDKDM EEDRASSSSG TIVQEAYGKI STSDNSMAQI LTPDSLNTEQ GPECSLRPNQ 4210 4220 4230 4240 4250 4260 TEEGTTPPIE ADTLDSSDAQ GGLEPRVEKT RPEPTEVLHA CKTQVAELEL WLQQANVAVE 4270 4280 4290 4300 4310 4320 PETLNADMQQ VLEQQLVGCQ AMLTEIEHKV AFLLETCKDQ GLGDNGATQH EAEALSLKLK 4330 4340 4350 4360 4370 4380 TVKCNLEKVQ MMLQEKHSED QHPTILKKSS EPEHQEALQP VNLSELESIV TERPQFSRQK 4390 4400 4410 4420 4430 4440 DFQQQQVLEL KPMEQKDFIK FIEFNAKKMW PQYCQHDNDT TQESSASNQA SSPENDVPDS 4450 4460 4470 4480 4490 4500 ILSPQGQNGD KWQYLHHELS SKIKLPLPQL VEPQVSTNMG ILPSVTMYNF RYPTTEELKT 4510 4520 4530 4540 4550 4560 YTTQLEDLRQ EASNLQTQEN MTEEAYINLD KKLFELFLTL SQCLSSVEEM LEMPRLYRED 4570 4580 4590 4600 4610 4620 GSGQQVHYET LALELKKLYL ALSDKKGDLL KAMTWPGENT NLLLECFDNL QVCLEHTQAA 4630 4640 4650 4660 4670 4680 AVCRSKSLKA GLDYNRSYQN EIKRLYHQLI KSKTSLQQSL NEISGQSVAE QLQKADAYTV 4690 4700 4710 4720 4730 4740 ELENAESRVA KLRDEGERLH LPYALLQEVY KLEDVLDSMW GMLRARYTEL SSPFVTESQQ 4750 4760 4770 4780 4790 4800 DALLQGMVEL VKIGKEKLAH GHLKQTKSKV ALQAQIENHK VFFQKLVADM LLIQAYSAKI 4810 4820 4830 4840 4850 4860 LPSLLQNRET FWAEQVTEVK ILEEKSRQCG MKLQSLLQKW EEFDENYASL EKDLEILIST 4870 4880 4890 4900 4910 4920 LPSVSLVEET EERLVERISF YQQIKRNIGG KHARLYQTLN EGKQLVASVS CPELEGQIAK 4930 4940 4950 4960 4970 4980 LEEQWLSLNK KIDHELHRLQ ALLKHLLSYN RDSDQLTKWL ESSQHTLNYW KEQSLNVSQD 4990 5000 5010 5020 5030 5040 LDTIRSNINN FFEFSKEVDE KSSLKTAVIS IGNQLLHLKE TDTATLRASL AQFEQKWTML 5050 5060 5070 5080 5090 5100 ITQLPDIQEK LHQLQMEKLP SRKAITEMIS WMNNVEHQTS DEDSVHSPSS ASQVKHLLQK 5110 5120 5130 5140 5150 5160 HKEFRMEMDY KQWIVDFVNQ SLLQLSTCDV ESKRYERTEF AEHLGEMNRQ WHRVHGMLNR 5170 5180 5190 5200 5210 5220 KIQHLEQLLE SITESENKIQ ILNNWLEAQE ERLKTLQKPE SVISVQKLLL DCQDIENQLA 5230 5240 5250 5260 5270 5280 IKSKALDELK QSYLTLESGA VPLLEDTASR IDELFQKRSS VLTQVNQLKT SMQSVLQEWK 5290 5300 5310 5320 5330 5340 IYDQLYDEVN MMTIRFWYCM EHSKPVVLSL ETLRCQVENL QSLQDEAESS EGSWEKLQEV 5350 5360 5370 5380 5390 5400 IGKLKGLCPS VAEIIEEKCQ NTHKRWTQVN QAIADQLQKA QSLLQLWKAY SNAHGEAAAR 5410 5420 5430 5440 5450 5460 LKQQEAKFQQ LANISMSGNN LAEILPPALQ DIKELQHDVQ KTKEAFLQNS SVLDRLPQPA 5470 5480 5490 5500 5510 5520 ESSTHMLLPG PLHSLQRAAY LEKMLLVKAN EFEFVLSQFK DFGVRLESLK GLIMHEEENL 5530 5540 5550 5560 5570 5580 DRLHQQEKEN PDSFLNHVLA LTAQSPDIEH LNEVSLKLPL SDVAVKTLQN MNRQWIRATA 5590 5600 5610 5620 5630 5640 TALERCSELQ GIGLNEKFLY CCEKWIQLLE KIEEALKVDV ANSLPELLEQ QKTYKMLEAE 5650 5660 5670 5680 5690 5700 VSINQTIADS YVTQSLQLLD TTEIENRPEF ITEFSKLTDR WQNAVQGVRQ RKGDVDGLVR 5710 5720 5730 5740 5750 5760 QWQDFTTSVE NLFRFLTDTS HLLSAVKGQE RFSLYQTRSL IHELKNKEIH FQRRRTTCAL 5770 5780 5790 5800 5810 5820 TLEAGEKLLL TTDLKTKESV GRRISQLQDS WKDMEPQLAE MIKQFQSTVE TWDQCEKKIK 5830 5840 5850 5860 5870 5880 ELKSRLQVLK AQSEDPLPEL HEDLHNEKEL IKELEQSLAS WTQNLKELQT MKADLTRHVL 5890 5900 5910 5920 5930 5940 VEDVMVLKEQ IEHLHRQWED LCLRVAIRKQ EIEDRLNTWV VFNEKNKELC AWLVQMENKV 5950 5960 5970 5980 5990 6000 LQTADISIEE MIEKLQKDCM EEINLFSENK LQLKQMGDQL IKASNKSRAA EIDDKLNKIN 6010 6020 6030 6040 6050 6060 DRWQHLFDVI GSRVKKLKET FAFIQQLDKN MSNLRTWLAR IESELSKPVV YDVCDDQEIQ 6070 6080 6090 6100 6110 6120 KRLAEQQDLQ RDIEQHSAGV ESVFNICDVL LHDSDACANE TECDSIQQTT RSLDRRWRNI 6130 6140 6150 6160 6170 6180 CAMSMERRMK IEETWRLWQK FLDDYSRFED WLKSAERTAA CPNSSEVLYT SAKEELKRFE 6190 6200 6210 6220 6230 6240 AFQRQIHERL TQLELINKQY RRLARENRTD TASRLKQMVH EGNQRWDNLQ RRVTAVLRRL 6250 6260 6270 6280 6290 6300 RHFTNQREEF EGTRESILVW LTEMDLQLTN VEHFSESDAD DKMRQLNGFQ QEITLNTNKI 6310 6320 6330 6340 6350 6360 DQLIVFGEQL IQKSEPLDAV LIEDELEELH RYCQEVFGRV SRFHRRLTSC TPGLEDEKEA 6370 6380 6390 6400 6410 6420 SENETDMEDP REIQTDSWRK RGESEEPSSP QSLCHLVAPG HERSGCETPV SVDSIPLEWD 6430 6440 6450 6460 6470 6480 HTGDVGGSSS HEEDEEGPYY SALSGKSISD GHSWHVPDSP SCPEHHYKQM EGDRNVPPVP 6490 6500 6510 6520 6530 6540 PASSTPYKPP YGKLLLPPGT DGGKEGPRVL NGNPQQEDGG LAGITEQQSG AFDRWEMIQA 6550 6560 6570 6580 6590 6600 QELHNKLKIK QNLQQLNSDI SAITTWLKKT EAELEMLKMA KPPSDIQEIE LRVKRLQEIL 6610 6620 6630 6640 6650 6660 KAFDTYKALV VSVNVSSKEF LQTESPESTE LQSRLRQLSL LWEAAQGAVD SWRGGLRQSL 6670 6680 6690 6700 6710 6720 MQCQDFHQLS QNLLLWLASA KNRRQKAHVT DPKADPRALL ECRRELMQLE KELVERQPQV 6730 6740 6750 6760 6770 6780 DMLQEISNSL LIKGHGEDCI EAEEKVHVIE KKLKQLREQV SQDLMALQGT QNPASPLPSF 6790 6800 6810 6820 6830 6840 DEVDSGDQPP ATSVPAPRAK QFRAVRTTEG EEETESRVPG STRPQRSFLS RVVRAALPLQ 6850 6860 6870 6880 LLLLLLLLLA CLLPSSEEDY SCTQANNFAR SFYPMLRYTN GPPPT
	Isoform 2 [UniParc]. Checksum: 7E7F66AF95A99F70	FASTA	6,907	798,862
	10 20 30 40 50 60 MASSPELPTE DEQGSWGIDD LHISLQAEQE DTQKKAFTCW INSQLARHTS PSVISDLFTD 70 80 90 100 110 120 IKKGHVLLDL LEVLSGQQLP RDKGSNTFQC RINIEHALTF LRNRSIKLIN IHVTDIIDGN 130 140 150 160 170 180 PSIILGLIWT IILHFHIEKL AQTLSCNYNQ PSLDDVSVVD SSPASSPPAK KCSKVQARWQ 190 200 210 220 230 240 MSARKALLLW AQEQCATYES VNVTDFKSSW RNGMAFLAII HALRPDLIDM KSVKHRSNKD 250 260 270 280 290 300 NLREAFRIAE QELKIPRLLE PEDVDVVDPD EKSIMTYVAQ FLQYSKDAPG TGEEAQGKVK 310 320 330 340 350 360 DAMGWLTLQK EKLQKLLKDS ENDTYFKKYN SLLSFMESFN EEKKSFLDVL SIKRDLDELD 370 380 390 400 410 420 KDHLQLREAW DGLDHQINAW KIKLNYALPP PLHQTEAWLQ EVEELMDEDL SASQDHSQAV 430 440 450 460 470 480 TLIQEKMTLF KSLMDRFEHH SNILLTFENK DENHLPLVPP NKLEEMKRRI NNILEKKFIL 490 500 510 520 530 540 LLEFHYYKCL VLGLVDEVKS KLDIWNIKYG SRESVELLLE DWHKFIEEKE FLARLDTSFQ 550 560 570 580 590 600 KCGEIYKNLA GECQNINKQY MMVKSDVCMY RKNIYNVKST LQKVLACWAT YVENLRLLRA 610 620 630 640 650 660 CFEETKKEEI KEVPFETLAQ WNLEHATLNE AGNFLVEVSN DVVGSSISKE LRRLNKRWRK 670 680 690 700 710 720 LVSKTQLEMN LPLMIKKQDQ PTFDNSGNIL SKEEKATVEF STDMSVELPE NYNQNIKAGE 730 740 750 760 770 780 KHEKENEEFT GQLKVAKDVE KLIGQVEIWE AEAKSVLDQD DVDTSMEESL KHLIAKGSMF 790 800 810 820 830 840 DELMARSEDM LQMDIQNISS QESFQHVLTT GLQAKIQEAK EKVQINVVKL IAALKNLTDV 850 860 870 880 890 900 SPDLDIRLKM EESQKELESY MMRAQQLLGQ RESPGELISK HKEALIISNT KSLAKYLKAV 910 920 930 940 950 960 EELKNNVTED IKMSLEEKSR DVCAKWESLH HELSLYVQQL KIDIEKGKLS DNILKLEKQI 970 980 990 1000 1010 1020 NKEKKLIRRG RTKGLIKEHE ACFSEEGCLY QLNHHMEVLR ELCEELPSQK SQQEVKRLLK 1030 1040 1050 1060 1070 1080 DYEQKIERLL KCASEIHMTL QPTAGGTSKN EGTITTSENR GGDPHSEAPF AKSDNQPSTE 1090 1100 1110 1120 1130 1140 KAMEPTMKFS LASVLRPLQE ESIMEKDYSA SINSLLERYD TYRDILEHHL QNNKFRITSD 1150 1160 1170 1180 1190 1200 FSSEEDRSSS CLQAKLTDLQ VIKNETDARW KEFEIISLKL ENHVNDIKKP FVIKERDTLK 1210 1220 1230 1240 1250 1260 ERERELQMTL NTRMESLETA LRLVLPVEKA SLLLCGSDLP LHKMAIQGFH LIDADRIYQH 1270 1280 1290 1300 1310 1320 LRNIQDSIAK QIEICNRLEE PGNFVLKELH PFDLHAMQNI ILKYKTQFEG MNHRVQRSED 1330 1340 1350 1360 1370 1380 TLKALEDFLA SLRTAKLSAE PVTDLSASDT QVAQENTLTV KNKEGEIHLM KDKAKHLDKC 1390 1400 1410 1420 1430 1440 LKMLDMSFKD AERGDDTSCE NLLDAFSIKL SETHGYGVQE EFTEENKLLE ACIFKNNELL 1450 1460 1470 1480 1490 1500 KNIQDVQSQI SKIGLKDPTV PAVKHRKKSL IRLDKVLDEY EEEKRHLQEM ANSLPHFKDG 1510 1520 1530 1540 1550 1560 REKTVNQQCQ NTVVLWENTK ALVTECLEQC GRVLELLKQY QNFKSILTTL IQKEESVISL 1570 1580 1590 1600 1610 1620 QASYMGKENL KKRIAEIEIV KEEFNEHLEV VDKINQVCKN LQFYLNKMKT FEEPPFEKEA 1630 1640 1650 1660 1670 1680 NIIVDRWLDI NEKTEDYYEN LGRALALWDK LFNLKNVIDE WTEKALQKME LHQLTEEDRE 1690 1700 1710 1720 1730 1740 RLKEELQVHE QKTSEFSRRV AEIQFLLQSS EIPLELQVME SSILNKMEHV QKCLTGESNC 1750 1760 1770 1780 1790 1800 HALSGSTAEL REDLDQAKTQ IGMTESLLKA LSPSDSLEIF TKLEEIQQQI LQQKHSMILL 1810 1820 1830 1840 1850 1860 ENQIGCLTPE LSELKKQYES VSDLFNTKKS VLQDHFSKLL NDQCKNFNDW FSNIKVNLKE 1870 1880 1890 1900 1910 1920 CFESSETKKS VEQKLQKLSD FLTLEGRNSK IKQVDSVLKH VKKHLPKAHV KELISWLVGQ 1930 1940 1950 1960 1970 1980 EFELEKMESI CQARAKELED SLQQLLRLQD DHRNLRKWLT NQEEKWKGME EPGEKTELFC 1990 2000 2010 2020 2030 2040 QALARKREQF ESVAQLNNSL KEYGFTEEEE IIMEATCLMD RYQTLLRQLS EIEEEDKLLP 2050 2060 2070 2080 2090 2100 TEDQSFNDLA HDVIHWIKEI KESLMVLNSS EGKMPLEERI QKIKEIILLK PEGDARIETI 2110 2120 2130 2140 2150 2160 MKQAESSEAP LVQKTLTDIS NQWDNTLHLA STYLSHQEKL LLEGEKYLQS KEDLRLMLIE 2170 2180 2190 2200 2210 2220 LKKKQEAGFA LQHGLQEKKA QLKIYKKFLK KAQDLTSLLK ELKSQGNYLL ECTKNPSFSE 2230 2240 2250 2260 2270 2280 EPWLEIKHLH ESLLQQLQDS VQNLDGHVRE HDSYQVCVTD LNTTLDNFSK EFVSFSDKPV 2290 2300 2310 2320 2330 2340 DQIAVEEKLQ KLQELENRLS LQDGTLKKIL ALAKSVKQNT SSVGQKIIKD DIKSLQCKQK 2350 2360 2370 2380 2390 2400 DLENRLASAK QEMECCLNSI LKSKRSTEKK GKFTLPGREK QATSDVQEST QESAAVEKLE 2410 2420 2430 2440 2450 2460 EDWEINKDSA VEMAMSKQLS LNAQESMKNT EDERKVNELQ NQPLELDTML RNEQLEEIEK 2470 2480 2490 2500 2510 2520 LYTQLEAKKA AIKPLEQTEC LNKTETGALV LHNIGYSAQH LDNLLQALIT LKKNKESQYC 2530 2540 2550 2560 2570 2580 VLRDFQEYLA AVESSMKALL TDKESLKVGP LDSVTYLDKI KKFIASIEKE KDSLGNLKIK 2590 2600 2610 2620 2630 2640 WENLSNHVTD MDKKLLESQI KQLEHGWEQV EQQIQKKYSQ QVVEYDEFTT LMNKVQDTEI 2650 2660 2670 2680 2690 2700 SLQQQQQHLQ LRLKSPEERA GNQSMIALTT DLQATKHGFS VLKGQAELQM KRIWGEKEKK 2710 2720 2730 2740 2750 2760 NLEDGINNLK KQWETLEPLH LEAENQIKKC DIRNKMKETI LWAKNLLGEL NPSIPLLPDD 2770 2780 2790 2800 2810 2820 ILSQIRKCKV THDGILARQQ SVESLAEEVK DKVPSLTTYE GSDLNNTLED LRNQYQMLVL 2830 2840 2850 2860 2870 2880 KSTQRSQQLE FKLEERSNFF AIIRKFQLMV QESETLIIPR VETAATEAEL KHHHVTLEAS 2890 2900 2910 2920 2930 2940 QKELQEIDSG ISTHLQELTN IYEELNVFER LFLEDQLKNL KIRTNRIQRF IQNTCNEVEH 2950 2960 2970 2980 2990 3000 KIKFCRQFHE KTSALQEEAD SIQRNELLLN QEVNKGVKEE IYNLKDRLTA IKCCILQVLK 3010 3020 3030 3040 3050 3060 LKKVFDYIGL NWDFSQLDQL QTQVFEKEKE LEEKIKQLDT FEEEHGKYQA LLSKMRAIDL 3070 3080 3090 3100 3110 3120 QIKKMTEVVL KAPDSSPESR RLNAQILSQR IEKAKCLCDE IIKKLNENKT FDDSFKEKEI 3130 3140 3150 3160 3170 3180 LQIKLNAEEN DKLYKVLQNM VLELSPKELD EKNCQDKLET SLHVLNQIKS QLQQPLLINL 3190 3200 3210 3220 3230 3240 EIKHIQNEKD NCEAFQEQVW AEMCSIKAVT AIEKQREENS SEASDVETKL REFEDLQMQL 3250 3260 3270 3280 3290 3300 NTSIDLRTNV LNDAYENLTR YKEAVTRAVE SITSLEAIII PYRVDVGNPE ESLEMPLRKQ 3310 3320 3330 3340 3350 3360 EELESTVAHI QDLTEKLGMI SSPEAKLQLQ YTLQELVSKN SAMKEAFKAQ ETEAERYLEN 3370 3380 3390 3400 3410 3420 YKCYRKMEED IYTNLSKMET VLGQSMSSLP LSYREALERL EQSKALVSNL ISTKEELMKL 3430 3440 3450 3460 3470 3480 RQILRLLRLR CTENDGICLL KIVSALWEKW LSLLEAAKEW EMWCEELKQE WKFVSEEIER 3490 3500 3510 3520 3530 3540 EAIILDNLQE ELPEISKTKE AATTEELSEL LDCLCQYGEN VEKQQLLLTL LLQRIRSIQN 3550 3560 3570 3580 3590 3600 VPESSGAVET VPAFQEITSM KERCNKLLQK VQKNKELVQT EIQERHSFTK EIIALKNFFQ 3610 3620 3630 3640 3650 3660 QTTTSFQNMA FQDHPEKSEQ FEELQSILKK GKLTFENIME KLRIKYSEMY TIVPAEIESQ 3670 3680 3690 3700 3710 3720 VEECRKALED IDEKISNEVL KSSPSYAMRR KIEEINNGLH NVEKMLQQKS KNIEKAQEIQ 3730 3740 3750 3760 3770 3780 KKMWDELDLW HSKLNELDSE VQDIVEQDPG QAQEWMDNLM IPFQQYQQVS QRAECRTSQL 3790 3800 3810 3820 3830 3840 NKATVKMEEY SDLLKSTEAW IENTSHLLAN PADYDSLRTL SHHASTVQMA LEDSEQKHNL 3850 3860 3870 3880 3890 3900 LHSIFMDLED LSIIFETDEL TQSIQELSNQ VTALQQKIME SLPQIQRMAD DVVAIESEVK 3910 3920 3930 3940 3950 3960 SMEKRVSKIK TILLSKEIFD FSPEEHLKHG EVILENIRPM KKTIAEIVSY QVELRLPQTG 3970 3980 3990 4000 4010 4020 MKPLPVFQRT NQLLQDIKLL ENVTQEQNEL LKVVIKQTNE WDEEIENLKQ ILNNYSAQFS 4030 4040 4050 4060 4070 4080 LEHMSPDQAD KLPQLQGEIE RMEKQILSLN QRKEDLLVDL KATVLNLHQH LKQEQEGVER 4090 4100 4110 4120 4130 4140 DRLPAVTSEE GGVAERDASE RKLNRRGSMS YLAAVEEEVE ESSVKSDNGD EKAEPSPQSW 4150 4160 4170 4180 4190 4200 SSLWKHDKDM EEDRASSSSG TIVQEAYGKI STSDNSMAQI LTPDSLNTEQ GPECSLRPNQ 4210 4220 4230 4240 4250 4260 TEEGTTPPIE ADTLDSSDAQ GGLEPRVEKT RPEPTEVLHA CKTQVAELEL WLQQANVAVE 4270 4280 4290 4300 4310 4320 PETLNADMQQ VLEQQLVGCQ AMLTEIEHKV AFLLETCKDQ GLGDNGATQH EAEALSLKLK 4330 4340 4350 4360 4370 4380 TVKCNLEKVQ MMLQEKHSED QHPTILKKSS EPEHQEALQP VNLSELESIV TERPQFSRQK 4390 4400 4410 4420 4430 4440 DFQQQQVLEL KPMEQKDFIK FIEFNAKKMW PQYCQHDNDT TQESSASNQA SSPENDVPDS 4450 4460 4470 4480 4490 4500 ILSPQGQNGD KWQYLHHELS SKIKLPLPQL VEPQVSTNMG ILPSVTMYNF RYPTTEELKT 4510 4520 4530 4540 4550 4560 YTTQLEDLRQ EASNLQTQEN MTEEAYINLD KKLFELFLTL SQCLSSVEEM LEMPRLYRED 4570 4580 4590 4600 4610 4620 GSGQQVHYET LALELKKLYL ALSDKKGDLL KAMTWPGENT NLLLECFDNL QVCLEHTQAA 4630 4640 4650 4660 4670 4680 AVCRSKSLKA GLDYNRSYQN EIKRLYHQLI KSKTSLQQSL NEISGQSVAE QLQKADAYTV 4690 4700 4710 4720 4730 4740 ELENAESRVA KLRDEGERLH LPYALLQEVY KLEDVLDSMW GMLRARYTEL SSPFVTESQQ 4750 4760 4770 4780 4790 4800 DALLQGMVEL VKIGKEKLAH GHLKQTKSKV ALQAQIENHK VFFQKLVADM LLIQAYSAKI 4810 4820 4830 4840 4850 4860 LPSLLQNRET FWAEQVTEVK ILEEKSRQCG MKLQSLLQKW EEFDENYASL EKDLEILIST 4870 4880 4890 4900 4910 4920 LPSVSLVEET EERLVERISF YQQIKRNIGG KHARLYQTLN EGKQLVASVS CPELEGQIAK 4930 4940 4950 4960 4970 4980 LEEQWLSLNK KIDHELHRLQ ALLKHLLSYN RDSDQLTKWL ESSQHTLNYW KEQSLNVSQD 4990 5000 5010 5020 5030 5040 LDTIRSNINN FFEFSKEVDE KSSLKTAVIS IGNQLLHLKE TDTATLRASL AQFEQKWTML 5050 5060 5070 5080 5090 5100 ITQLPDIQEK LHQLQMEKLP SRKAITEMIS WMNNVEHQTS DEDSVHSPSS ASQVKHLLQK 5110 5120 5130 5140 5150 5160 HKEFRMEMDY KQWIVDFVNQ SLLQLSTCDV ESKRYERTEF AEHLGEMNRQ WHRVHGMLNR 5170 5180 5190 5200 5210 5220 KIQHLEQLLE SITESENKIQ ILNNWLEAQE ERLKTLQKPE SVISVQKLLL DCQDIENQLA 5230 5240 5250 5260 5270 5280 IKSKALDELK QSYLTLESGA VPLLEDTASR IDELFQKRSS VLTQVNQLKT SMQSVLQEWK 5290 5300 5310 5320 5330 5340 IYDQLYDEVN MMTIRFWYCM EHSKPVVLSL ETLRCQVENL QSLQDEAESS EGSWEKLQEV 5350 5360 5370 5380 5390 5400 IGKLKGLCPS VAEIIEEKCQ NTHKRWTQVN QAIADQLQKA QSLLQLWKAY SNAHGEAAAR 5410 5420 5430 5440 5450 5460 LKQQEAKFQQ LANISMSGNN LAEILPPALQ DIKELQHDVQ KTKEAFLQNS SVLDRLPQPA 5470 5480 5490 5500 5510 5520 ESSTHMLLPG PLHSLQRAAY LEKMLLVKAN EFEFVLSQFK DFGVRLESLK GLIMHEEENL 5530 5540 5550 5560 5570 5580 DRLHQQEKEN PDSFLNHVLA LTAQSPDIEH LNEVSLKLPL SDVAVKTLQN MNRQWIRATA 5590 5600 5610 5620 5630 5640 TALERCSELQ GIGLNEKFLY CCEKWIQLLE KIEEALKVDV ANSLPELLEQ QKTYKMLEAE 5650 5660 5670 5680 5690 5700 VSINQTIADS YVTQSLQLLD TTEIENRPEF ITEFSKLTDR WQNAVQGVRQ RKGDVDGLVR 5710 5720 5730 5740 5750 5760 QWQDFTTSVE NLFRFLTDTS HLLSAVKGQE RFSLYQTRSL IHELKNKEIH FQRRRTTCAL 5770 5780 5790 5800 5810 5820 TLEAGEKLLL TTDLKTKESV GRRISQLQDS WKDMEPQLAE MIKQFQSTVE TWDQCEKKIK 5830 5840 5850 5860 5870 5880 ELKSRLQVLK AQSEDPLPEL HEDLHNEKEL IKELEQSLAS WTQNLKELQT MKADLTRHVL 5890 5900 5910 5920 5930 5940 VEDVMVLKEQ IEHLHRQWED LCLRVAIRKQ EIEDRLNTWV VFNEKNKELC AWLVQMENKV 5950 5960 5970 5980 5990 6000 LQTADISIEE MIEKLQKDCM EEINLFSENK LQLKQMGDQL IKASNKSRAA EIDDKLNKIN 6010 6020 6030 6040 6050 6060 DRWQHLFDVI GSRVKKLKET FAFIQQLDKN MSNLRTWLAR IESELSKPVV YDVCDDQEIQ 6070 6080 6090 6100 6110 6120 KRLAEQQDLQ RDIEQHSAGV ESVFNICDVL LHDSDACANE TECDSIQQTT RSLDRRWRNI 6130 6140 6150 6160 6170 6180 CAMSMERRMK IEETWRLWQK FLDDYSRFED WLKSAERTAA CPNSSEVLYT SAKEELKRFE 6190 6200 6210 6220 6230 6240 AFQRQIHERL TQLELINKQY RRLARENRTD TASRLKQMVH EGNQRWDNLQ RRVTAVLRRL 6250 6260 6270 6280 6290 6300 RHFTNQREEF EGTRESILVW LTEMDLQLTN VEHFSESDAD DKMRQLNGFQ QEITLNTNKI 6310 6320 6330 6340 6350 6360 DQLIVFGEQL IQKSEPLDAV LIEDELEELH RYCQEVFGRV SRFHRRLTSC TPGLEDEKEA 6370 6380 6390 6400 6410 6420 SENETDMEDP REIQTDSWRK RGESEEPSSP QSLCHLVAPG HERSGCETPV SVDSIPLEWD 6430 6440 6450 6460 6470 6480 HTGDVGGSSS HEEDEEGPYY SALSDVEIPE NPEAYLKMTT KTLKASSGKS ISDGHSWHVP 6490 6500 6510 6520 6530 6540 DSPSCPEHHY KQMEGDRNVP PVPPASSTPY KPPYGKLLLP PGTDGGKEGP RVLNGNPQQE 6550 6560 6570 6580 6590 6600 DGGLAGITEQ QSGAFDRWEM IQAQELHNKL KIKQNLQQLN SDISAITTWL KKTEAELEML 6610 6620 6630 6640 6650 6660 KMAKPPSDIQ EIELRVKRLQ EILKAFDTYK ALVVSVNVSS KEFLQTESPE STELQSRLRQ 6670 6680 6690 6700 6710 6720 LSLLWEAAQG AVDSWRGGLR QSLMQCQDFH QLSQNLLLWL ASAKNRRQKA HVTDPKADPR 6730 6740 6750 6760 6770 6780 ALLECRRELM QLEKELVERQ PQVDMLQEIS NSLLIKGHGE DCIEAEEKVH VIEKKLKQLR 6790 6800 6810 6820 6830 6840 EQVSQDLMAL QGTQNPASPL PSFDEVDSGD QPPATSVPAP RAKFRAVRTT EGEEETESRV 6850 6860 6870 6880 6890 6900 PGSTRPQRSF LSRVVRAALP LQLLLLLLLL LACLLPSSEE DYSCTQANNF ARSFYPMLRY TNGPPPT
	Isoform 3 [UniParc]. Checksum: 554952A1E70DF621	FASTA	855	98,039
	10 20 30 40 50 60 MSNLRTWLAR IESELSKPVV YDVCDDQEIQ KRLAEQQDLQ RDIEQHSAGV ESVFNICDVL 70 80 90 100 110 120 LHDSDACANE TECDSIQQTT RSLDRRWRNI CAMSMERRMK IEETWRLWQK FLDDYSRFED 130 140 150 160 170 180 WLKSAERTAA CPNSSEVLYT SAKEELKRFE AFQRQIHERL TQLELINKQY RRLARENRTD 190 200 210 220 230 240 TASRLKQMVH EGNQRWDNLQ RRVTAVLRRL RHFTNQREEF EGTRESILVW LTEMDLQLTN 250 260 270 280 290 300 VEHFSESDAD DKMRQLNGFQ QEITLNTNKI DQLIVFGEQL IQKSEPLDAV LIEDELEELH 310 320 330 340 350 360 RYCQEVFGRV SRFHRRLTSC TPGLEDEKEA SENETDMEDP REIQTDSWRK RGESEEPSSP 370 380 390 400 410 420 QSLCHLVAPG HERSGCETPV SVDSIPLEWD HTGDVGGSSS HEEDEEGPYY SALSGKSISD 430 440 450 460 470 480 GHSWHVPDSP SCPEHHYKQM EGDRNVPPVP PASSTPYKPP YGKLLLPPGT DGGKEGPRVL 490 500 510 520 530 540 NGNPQQEDGG LAGITEQQSG AFDRWEMIQA QELHNKLKIK QNLQQLNSDI SAITTWLKKT 550 560 570 580 590 600 EAELEMLKMA KPPSDIQEIE LRVKRLQEIL KAFDTYKALV VSVNVSSKEF LQTESPESTE 610 620 630 640 650 660 LQSRLRQLSL LWEAAQGAVD SWRGGLRQSL MQCQDFHQLS QNLLLWLASA KNRRQKAHVT 670 680 690 700 710 720 DPKADPRALL ECRRELMQLE KELVERQPQV DMLQEISNSL LIKGHGEDCI EAEEKVHVIE 730 740 750 760 770 780 KKLKQLREQV SQDLMALQGT QNPASPLPSF DEVDSGDQPP ATSVPAPRAK QFRAVRTTEG 790 800 810 820 830 840 EEETESRVPG STRPQRSFLS RVVRAALPLQ LLLLLLLLLA CLLPSSEEDY SCTQANNFAR 850 SFYPMLRYTN GPPPT
	Isoform 4 (Beta) [UniParc]. Checksum: CAE53C333FE028A0	FASTA	763	87,403
	10 20 30 40 50 60 MSMERRMKIE ETWRLWQKFL DDYSRFEDWL KSAERTAACP NSSEVLYTSA KEELKRFEAF 70 80 90 100 110 120 QRQIHERLTQ LELINKQYRR LARENRTDTA SRLKQMVHEG NQRWDNLQRR VTAVLRRLRH 130 140 150 160 170 180 FTNQREEFEG TRESILVWLT EMDLQLTNVE HFSESDADDK MRQLNGFQQE ITLNTNKIDQ 190 200 210 220 230 240 LIVFGEQLIQ KSEPLDAVLI EDELEELHRY CQEVFGRVSR FHRRLTSCTP GLEDEKEASE 250 260 270 280 290 300 NETDMEDPRE IQTDSWRKRG ESEEPSSPQS LCHLVAPGHE RSGCETPVSV DSIPLEWDHT 310 320 330 340 350 360 GDVGGSSSHE EDEEGPYYSA LSGKSISDGH SWHVPDSPSC PEHHYKQMEG DRNVPPVPPA 370 380 390 400 410 420 SSTPYKPPYG KLLLPPGTDG GKEGPRVLNG NPQQEDGGLA GITEQQSGAF DRWEMIQAQE 430 440 450 460 470 480 LHNKLKIKQN LQQLNSDISA ITTWLKKTEA ELEMLKMAKP PSDIQEIELR VKRLQEILKA 490 500 510 520 530 540 FDTYKALVVS VNVSSKEFLQ TESPESTELQ SRLRQLSLLW EAAQGAVDSW RGGLRQSLMQ 550 560 570 580 590 600 CQDFHQLSQN LLLWLASAKN RRQKAHVTDP KADPRALLEC RRELMQLEKE LVERQPQVDM 610 620 630 640 650 660 LQEISNSLLI KGHGEDCIEA EEKVHVIEKK LKQLREQVSQ DLMALQGTQN PASPLPSFDE 670 680 690 700 710 720 VDSGDQPPAT SVPAPRAKQF RAVRTTEGEE ETESRVPGST RPQRSFLSRV VRAALPLQLL 730 740 750 760 LLLLLLLACL LPSSEEDYSC TQANNFARSF YPMLRYTNGP PPT
	Isoform 5 (Alpha) [UniParc]. Checksum: FA2F772713B7A977	FASTA	556	62,199
	10 20 30 40 50 60 MEDPREIQTD SWRKRGESEE PSSPQSLCHL VAPGHERSGC ETPVSVDSIP LEWDHTGDVG 70 80 90 100 110 120 GSSSHEEDEE GPYYSALSDV EIPENPEAYL KMTTKTLKAS SGKSISDGHS WHVPDSPSCP 130 140 150 160 170 180 EHHYKQMEGD RNVPPVPPAS STPYKPPYGK LLLPPGTDGG KEGPRVLNGN PQQEDGGLAG 190 200 210 220 230 240 ITEQQSGAFD RWEMIQAQEL HNKLKIKQNL QQLNSDISAI TTWLKKTEAE LEMLKMAKPP 250 260 270 280 290 300 SDIQEIELRV KRLQEILKAF DTYKALVVSV NVSSKEFLQT ESPESTELQS RLRQLSLLWE 310 320 330 340 350 360 AAQGAVDSWR GGLRQSLMQC QGSKTRPRSD VLFFKDFHQL SQNLLLWLAS AKNRRQKAHV 370 380 390 400 410 420 TDPKADPRAL LECRRELMQL EKELVERQPQ VDMLQEISNS LLIKGHGEDC IEAEEKVHVI 430 440 450 460 470 480 EKKLKQLREQ VSQDLMALQG TQNPASPLPS FDEVDSGDQP PATSVPAPRA KQFRAVRTTE 490 500 510 520 530 540 GEEETESRVP GSTRPQRSFL SRVVRAALPL QLLLLLLLLL ACLLPSSEED YSCTQANNFA 550 RSFYPMLRYT NGPPPT
	Isoform 6 [UniParc]. Checksum: 8BF416B8EEA07C63	FASTA	429	48,159
	10 20 30 40 50 60 MEGDRNVPPV PPASSTPYKP PYGKLLLPPG TDGGKEGPRV LNGNPQQEDG GLAGITEQQS 70 80 90 100 110 120 GAFDRWEMIQ AQELHNKLKI KQNLQQLNSD ISAITTWLKK TEAELEMLKM AKPPSDIQEI 130 140 150 160 170 180 ELRVKRLQEI LKAFDTYKAL VVSVNVSSKE FLQTESPEST ELQSRLRQLS LLWEAAQGAV 190 200 210 220 230 240 DSWRGGLRQS LMQCQGSKTR PRSDVLFFKD FHQLSQNLLL WLASAKNRRQ KAHVTDPKAD 250 260 270 280 290 300 PRALLECRRE LMQLEKELVE RQPQVDMLQE ISNSLLIKGH GEDCIEAEEK VHVIEKKLKQ 310 320 330 340 350 360 LREQVSQDLM ALQGTQNPAS PLPSFDEVDS GDQPPATSVP APRAKFRAVR TTEGEEETES 370 380 390 400 410 420 RVPGSTRPQR SFLSRVVRAA LPLQLLLLLL LLLACLLPSS EEDYSCTQAN NFARSFYPML RYTNGPPPT
	Isoform 7 (Gamma) [UniParc]. Checksum: 5F53FE3B7E37EDAB	FASTA	3,270	377,193
	10 20 30 40 50 60 MEKLRIKYSE MYTIVPAEIE SQVEECRKAL EDIDEKISNE VLKSSPSYAM RRKIEEINNG 70 80 90 100 110 120 LHNVEKMLQQ KSKNIEKAQE IQKKMWDELD LWHSKLNELD SEVQDIVEQD PGQAQEWMDN 130 140 150 160 170 180 LMIPFQQYQQ VSQRAECRTS QLNKATVKME EYSDLLKSTE AWIENTSHLL ANPADYDSLR 190 200 210 220 230 240 TLSHHASTVQ DSKCFRSGPR PNIYVSYYVT VIQMALEDSE QKHNLLHSIF MDLEDLSIIF 250 260 270 280 290 300 ETDELTQSIQ ELSNQVTALQ QKIMESLPQI QRMADDVVAI ESEVKSMEKR VSKIKTILLS 310 320 330 340 350 360 KEIFDFSPEE HLKHGEVILE NIRPMKKTIA EIVSYQVELR LPQTGMKPLP VFQRTNQLLQ 370 380 390 400 410 420 DIKLLENVTQ EQNELLKVVI KQTNEWDEEI ENLKQILNNY SAQFSLEHMS PDQADKLPQL 430 440 450 460 470 480 QGEIERMEKQ ILSLNQRKED LLVDLKATVL NLHQHLKQEQ EGVERDRLPA VTSEEGGVAE 490 500 510 520 530 540 RDASERKLNR RGSMSYLAAV EEEVEESSVK SDNGDEKAEP SPQSWSSLWK HDKDMEEDRA 550 560 570 580 590 600 SSSSGTIVQE AYGKISTSDN SMAQILTPDS LNTEQGPECS LRPNQTEEGT TPPIEADTLD 610 620 630 640 650 660 SSDAQGGLEP RVEKTRPEPT EVLHACKTQV AELELWLQQA NVAVEPETLN ADMQQVLEQQ 670 680 690 700 710 720 LVGCQAMLTE IEHKVAFLLE TCKDQGLGDN GATQHEAEAL SLKLKTVKCN LEKVQMMLQE 730 740 750 760 770 780 KHSEDQHPTI LKKSSEPEHQ EALQPVNLSE LESIVTERPQ FSRQKDFQQQ QVLELKPMEQ 790 800 810 820 830 840 KDFIKFIEFN AKKMWPQYCQ HDNDTTQESS ASNQASSPEN DVPDSILSPQ GQNGDKWQYL 850 860 870 880 890 900 HHELSSKIKL PLPQLVEPQV STNMGILPSV TMYNFRYPTT EELKTYTTQL EDLRQEASNL 910 920 930 940 950 960 QTQENMTEEA YINLDKKLFE LFLTLSQCLS SVEEMLEMPR LYREDGSGQQ VHYETLALEL 970 980 990 1000 1010 1020 KKLYLALSDK KGDLLKAMTW PGENTNLLLE CFDNLQVCLE HTQAAAVCRS KSLKAGLDYN 1030 1040 1050 1060 1070 1080 RSYQNEIKRL YHQLIKSKTS LQQSLNEISG QSVAEQLQKA DAYTVELENA ESRVAKLRDE 1090 1100 1110 1120 1130 1140 GERLHLPYAL LQEVYKLEDV LDSMWGMLRA RYTELSSPFV TESQQDALLQ GMVELVKIGK 1150 1160 1170 1180 1190 1200 EKLAHGHLKQ TKSKVALQAQ IENHKVFFQK LVADMLLIQA YSAKILPSLL QNRETFWAEQ 1210 1220 1230 1240 1250 1260 VTEVKILEEK SRQCGMKLQS LLQKWEEFDE NYASLEKDLE ILISTLPSVS LVEETEERLV 1270 1280 1290 1300 1310 1320 ERISFYQQIK RNIGGKHARL YQTLNEGKQL VASVSCPELE GQIAKLEEQW LSLNKKIDHE 1330 1340 1350 1360 1370 1380 LHRLQALLKH LLSYNRDSDQ LTKWLESSQH TLNYWKEQSL NVSQDLDTIR SNINNFFEFS 1390 1400 1410 1420 1430 1440 KEVDEKSSLK TAVISIGNQL LHLKETDTAT LRASLAQFEQ KWTMLITQLP DIQEKLHQLQ 1450 1460 1470 1480 1490 1500 MEKLPSRKAI TEMISWMNNV EHQTSDEDSV HSPSSASQVK HLLQKHKEFR MEMDYKQWIV 1510 1520 1530 1540 1550 1560 DFVNQSLLQL STCDVESKRY ERTEFAEHLG EMNRQWHRVH GMLNRKIQHL EQLLESITES 1570 1580 1590 1600 1610 1620 ENKIQILNNW LEAQEERLKT LQKPESVISV QKLLLDCQDI ENQLAIKSKA LDELKQSYLT 1630 1640 1650 1660 1670 1680 LESGAVPLLE DTASRIDELF QKRSSVLTQV NQLKTSMQSV LQEWKIYDQL YDEVNMMTIR 1690 1700 1710 1720 1730 1740 FWYCMEHSKP VVLSLETLRC QVENLQSLQD EAESSEGSWE KLQEVIGKLK GLCPSVAEII 1750 1760 1770 1780 1790 1800 EEKCQNTHKR WTQVNQAIAD QLQKAQSLLQ LWKAYSNAHG EAAARLKQQE AKFQQLANIS 1810 1820 1830 1840 1850 1860 MSGNNLAEIL PPALQDIKEL QHDVQKTKEA FLQNSSVLDR LPQPAESSTH MLLPGPLHSL 1870 1880 1890 1900 1910 1920 QRAAYLEKML LVKANEFEFV LSQFKDFGVR LESLKGLIMH EEENLDRLHQ QEKENPDSFL 1930 1940 1950 1960 1970 1980 NHVLALTAQS PDIEHLNEVS LKLPLSDVAV KTLQNMNRQW IRATATALER CSELQGIGLN 1990 2000 2010 2020 2030 2040 EKFLYCCEKW IQLLEKIEEA LKVDVANSLP ELLEQQKTYK MLEAEVSINQ TIADSYVTQS 2050 2060 2070 2080 2090 2100 LQLLDTTEIE NRPEFITEFS KLTDRWQNAV QGVRQRKGDV DGLVRQWQDF TTSVENLFRF 2110 2120 2130 2140 2150 2160 LTDTSHLLSA VKGQERFSLY QTRSLIHELK NKEIHFQRRR TTCALTLEAG EKLLLTTDLK 2170 2180 2190 2200 2210 2220 TKESVGRRIS QLQDSWKDME PQLAEMIKQF QSTVETWDQC EKKIKELKSR LQVLKAQSED 2230 2240 2250 2260 2270 2280 PLPELHEDLH NEKELIKELE QSLASWTQNL KELQTMKADL TRHVLVEDVM VLKEQIEHLH 2290 2300 2310 2320 2330 2340 RQWEDLCLRV AIRKQEIEDR LNTWVVFNEK NKELCAWLVQ MENKVLQTAD ISIEEMIEKL 2350 2360 2370 2380 2390 2400 QKDCMEEINL FSENKLQLKQ MGDQLIKASN KSRAAEIDDK LNKINDRWQH LFDVIGSRVK 2410 2420 2430 2440 2450 2460 KLKETFAFIQ QLDKNMSNLR TWLARIESEL SKPVVYDVCD DQEIQKRLAE QQDLQRDIEQ 2470 2480 2490 2500 2510 2520 HSAGVESVFN ICDVLLHDSD ACANETECDS IQQTTRSLDR RWRNICAMSM ERRMKIEETW 2530 2540 2550 2560 2570 2580 RLWQKFLDDY SRFEDWLKSA ERTAACPNSS EVLYTSAKEE LKRFEAFQRQ IHERLTQLEL 2590 2600 2610 2620 2630 2640 INKQYRRLAR ENRTDTASRL KQMVHEGNQR WDNLQRRVTA VLRRLRHFTN QREEFEGTRE 2650 2660 2670 2680 2690 2700 SILVWLTEMD LQLTNVEHFS ESDADDKMRQ LNGFQQEITL NTNKIDQLIV FGEQLIQKSE 2710 2720 2730 2740 2750 2760 PLDAVLIEDE LEELHRYCQE VFGRVSRFHR RLTSCTPGLE DEKEASENET DMEDPREIQT 2770 2780 2790 2800 2810 2820 DSWRKRGESE EPSSPQSLCH LVAPGHERSG CETPVSVDSI PLEWDHTGDV GGSSSHEEDE 2830 2840 2850 2860 2870 2880 EGPYYSALSG KSISDGHSWH VPDSPSCPEH HYKQMEGDRN VPPVPPASST PYKPPYGKLL 2890 2900 2910 2920 2930 2940 LPPGTDGGKE GPRVLNGNPQ QEDGGLAGIT EQQSGAFDRW EMIQAQELHN KLKIKQNLQQ 2950 2960 2970 2980 2990 3000 LNSDISAITT WLKKTEAELE MLKMAKPPSD IQEIELRVKR LQEILKAFDT YKALVVSVNV 3010 3020 3030 3040 3050 3060 SSKEFLQTES PESTELQSRL RQLSLLWEAA QGAVDSWRGG LRQSLMQCQD FHQLSQNLLL 3070 3080 3090 3100 3110 3120 WLASAKNRRQ KAHVTDPKAD PRALLECRRE LMQLEKELVE RQPQVDMLQE ISNSLLIKGH 3130 3140 3150 3160 3170 3180 GEDCIEAEEK VHVIEKKLKQ LREQVSQDLM ALQGTQNPAS PLPSFDEVDS GDQPPATSVP 3190 3200 3210 3220 3230 3240 APRAKQFRAV RTTEGEEETE SRVPGSTRPQ RSFLSRVVRA ALPLQLLLLL LLLLACLLPS 3250 3260 3270 SEEDYSCTQA NNFARSFYPM LRYTNGPPPT
	Isoform 8 [UniParc]. Checksum: A0DDB990EFD42352	FASTA	285	32,239
	10 20 30 40 50 60 MASSPELPTE DEQGSWGIDD LHISLQAEQE DTQKKAFTCW INSQLARHTS PSVISDLFTD 70 80 90 100 110 120 IKKGHVLLDL LEVLSGQQLP RDKGSNTFQC RINIEHALTF LRNRSIKLIN IHVTDIIDGN 130 140 150 160 170 180 PSIILGLIWT IILHFHIEKL AQTLSCNYNQ PSLDDVSVVD SSPASSPPAK KCSKVQARWQ 190 200 210 220 230 240 MSARKALLLW AQEQCATYES VNVTDFKSSW RNGMAFLAII HALRPDLIDM KSVKHRSNKD 250 260 270 280 NLREAFRIAE QELKIPRLLE PEDAWRSSAL YRIYMPGTVS CASYL
	Isoform 9 (NUANCE-N-33) [UniParc]. Checksum: 0683CC937EBD8A92	FASTA	267	30,270
	10 20 30 40 50 60 MASSPELPTE DEQGSWGIDD LHISLQAEQE DTQKKAFTCW INSQLARHTS PSVISDLFTD 70 80 90 100 110 120 IKKGHVLLDL LEVLSGQQLP RDKGSNTFQC RINIEHALTF LRNRSIKLIN IHVTDIIDGN 130 140 150 160 170 180 PSIILGLIWT IILHFHIEKL AQTLSCNYNQ PSLDDVSVVD SSPASSPPAK KCSKVQARWQ 190 200 210 220 230 240 MSARKALLLW AQEQCATYES VNVTDFKSSW RNGMAFLAII HALRPDLIDM KSVKHRSNKD 250 260 NLREAFRIAE QELKIPRLLE PEAYKNF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NUANCE, a giant protein connecting the nucleus and actin cytoskeleton." Zhen Y.-Y., Libotte T., Munck M., Noegel A.A., Korenbaum E. J. Cell Sci. 115:3207-3222(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9), FUNCTION, CHARACTERIZATION, INTERACTION WITH F-ACTIN, VARIANTS THR-1969; VAL-2284; ASN-2359; THR-2395; GLY-2802; VAL-2942; HIS-3253; ARG-3309 AND MET-5186.
[2]	"Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues." Zhang Q., Skepper J.N., Yang F., Davies J.D., Hegyi L., Roberts R.G., Weissberg P.L., Ellis J.A., Shanahan C.M. J. Cell Sci. 114:4485-4498(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6 AND 7).
[3]	"The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300." Zhang Q., Ragnauth C., Greener M.J., Shanahan C.M., Roberts R.G. Genomics 80:473-481(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Testis.
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8). Tissue: Brain.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-956 AND 5133-6885, VARIANT MET-5186. Tissue: Spleen and Tongue.
[8]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3367-6885 (ISOFORM 2). Tissue: Brain.
[9]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[10]	Ohara O., Nagase T., Kikuno R. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[11]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5754-6885.
[12]	"Nuclear membrane proteins with potential disease links found by subtractive proteomics." Schirmer E.C., Florens L., Guan T., Yates J.R. III, Gerace L. Science 301:1380-1382(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[13]	"Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle." Zhang Q., Ragnauth C.D., Skepper J.N., Worth N.F., Warren D.T., Roberts R.G., Weissberg P.L., Ellis J.A., Shanahan C.M. J. Cell Sci. 118:673-687(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH EMD AND LMNA.
[14]	"Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness." Stewart-Hutchinson P.J., Hale C.M., Wirtz D., Hodzic D. Exp. Cell Res. 314:1892-1905(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DOMAIN, INTERACTION WITH SUN1 AND SUN2.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4108, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton." Dawe H.R., Adams M., Wheway G., Szymanska K., Logan C.V., Noegel A.A., Gull K., Johnson C.A. J. Cell Sci. 122:2716-2726(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MKS3, FUNCTION.
[17]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4108, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[18]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-955, MASS SPECTROMETRY.
[19]	"Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes." Haque F., Mazzeo D., Patel J.T., Smallwood D.T., Ellis J.A., Shanahan C.M., Shackleton S. J. Biol. Chem. 285:3487-3498(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SUN1 AND SUN2.
[20]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2781 AND SER-6361, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[21]	"Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement." Luxton G.W., Gomes E.R., Folker E.S., Vintinner E., Gundersen G.G. Science 329:956-959(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[22]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[23]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2781, MASS SPECTROMETRY.
[24]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-5940 AND CYS-6200.
[25]	"Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity." Zhang Q., Bethmann C., Worth N.F., Davies J.D., Wasner C., Feuer A., Ragnauth C.D., Yi Q., Mellad J.A., Warren D.T., Wheeler M.A., Ellis J.A., Skepper J.N., Vorgerd M., Schlotter-Weigel B., Weissberg P.L., Roberts R.G., Wehnert M., Shanahan C.M. Hum. Mol. Genet. 16:2816-2833(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT EDMD5 MET-6211.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF435010 mRNA. Translation: AAL33547.1.
AF435011 mRNA. Translation: AAL33548.1.
AY061757 mRNA. Translation: AAL33800.1.
AY061758 mRNA. Translation: AAL33801.1.
AY061759 mRNA. Translation: AAL33802.1.
AY184204 mRNA. Translation: AAO27772.1.
AF495911 mRNA. Translation: AAN60443.1.
AL117404 mRNA. Translation: CAB55905.2. Different initiation.
AL162832 Genomic DNA. No translation available.
AL355094 Genomic DNA. No translation available.
AL359235 Genomic DNA. No translation available.
BC042134 mRNA. Translation: AAH42134.1.
BC071873 mRNA. Translation: AAH71873.1.
AK074055 mRNA. Translation: BAB84881.1. Different initiation.
AK090430 mRNA. Translation: BAC03411.1.
AK095241 mRNA. Translation: BAC04506.1.
AB023228 mRNA. Translation: BAA76855.3.
AL080133 mRNA. Translation: CAB45729.1. Different initiation.

IPI

IPI00239405.
IPI00239406.
IPI00239409.
IPI00239410.
IPI00239413.
IPI00239414.
IPI00412276.
IPI00815967.
IPI01009561.

PIR

T12520.
T17215.

RefSeq

NP_055995.4. NM_015180.4.
NP_878914.1. NM_182910.2.
NP_878917.1. NM_182913.2.
NP_878918.2. NM_182914.2.

UniGene

Hs.525392.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DXS	X-ray	2.71	B	6857-6885	[»]
4FI9	X-ray	3.05	B	6872-6885	[»]

ProteinModelPortal

Q8WXH0.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8WXH0. 5 interactions.

PTM databases

PhosphoSite

Q8WXH0.

Polymorphism databases

DMDM

116242809.

Proteomic databases

PaxDb

Q8WXH0.

PRIDE

Q8WXH0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000341472; ENSP00000344528; ENSG00000054654.
ENST00000344113; ENSP00000341781; ENSG00000054654.
ENST00000356081; ENSP00000348382; ENSG00000054654.
ENST00000357395; ENSP00000349969; ENSG00000054654.
ENST00000358025; ENSP00000350719; ENSG00000054654.
ENST00000394768; ENSP00000378249; ENSG00000054654.
ENST00000441438; ENSP00000396794; ENSG00000054654.
ENST00000458046; ENSP00000391937; ENSG00000054654.
ENST00000555002; ENSP00000450831; ENSG00000054654.
ENST00000555022; ENSP00000451009; ENSG00000054654.

GeneID

23224.

KEGG

hsa:23224.

UCSC

uc001xgk.3. human.
uc001xgl.3. human.
uc001xgm.3. human.
uc001xgn.3. human.
uc001xgs.3. human.
uc001xgt.3. human.
uc010aqa.3. human.

Organism-specific databases

CTD

23224.

GeneCards

GC14P064319.

HGNC

HGNC:17084. SYNE2.

HPA

HPA003435.

MIM

608442. gene.
612999. phenotype.

neXtProt

NX_Q8WXH0.

Orphanet

98853. Autosomal dominant Emery-Dreifuss muscular dystrophy.

PharmGKB

PA128394613.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5069.

OMA

EDWHKFI.

Enzyme and pathway databases

Reactome

REACT_111183. Meiosis.
REACT_115566. Cell Cycle.

Gene expression databases

ArrayExpress

Q8WXH0.

Bgee

Q8WXH0.

Genevestigator

Q8WXH0.

GermOnline

ENSG00000054654. Homo sapiens.

Family and domain databases

Gene3D

1.10.418.10. 2 hits.

InterPro

IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR012315. KASH.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]

Pfam

PF00307. CH. 2 hits.
PF10541. KASH. 1 hit.
PF00435. Spectrin. 3 hits.
[Graphical view]

SMART

SM00033. CH. 2 hits.
SM00150. SPEC. 18 hits.
[Graphical view]

SUPFAM

SSF47576. Calponin-homology. 1 hit.

PROSITE

PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS51049. KASH. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

23224.

NextBio

44823.

SOURCE

Search...

Entry information

Entry name

SYNE2_HUMAN

Accession

Primary (citable) accession number: Q8WXH0
Secondary accession number(s): Q540G1 , Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 122 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.