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Protein

G-protein coupled receptor 98

Gene

GPR98

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that may have an important role in the development of the central nervous system.

GO - Molecular functioni

  • calcium ion binding Source: HGNC
  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: GDB
  • maintenance of animal organ identity Source: HGNC
  • nervous system development Source: UniProtKB
  • neurological system process Source: HGNC
  • photoreceptor cell maintenance Source: HGNC
  • sensory perception of light stimulus Source: HGNC
  • sensory perception of sound Source: HGNC
  • single organismal cell-cell adhesion Source: UniProtKB
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164199-MONOMER.

Protein family/group databases

TCDBi2.A.19.3.6. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 98
Alternative name(s):
Monogenic audiogenic seizure susceptibility protein 1 homolog
Usher syndrome type-2C protein
Very large G-protein coupled receptor 1
Gene namesi
Name:GPR98
Synonyms:KIAA0686, KIAA1943, MASS1, VLGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:17416. GPR98.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 5908ExtracellularSequence analysisAdd BLAST5879
Transmembranei5909 – 5929HelicalSequence analysisAdd BLAST21
Topological domaini5930 – 5939CytoplasmicSequence analysis10
Transmembranei5940 – 5960HelicalSequence analysisAdd BLAST21
Topological domaini5961 – 5979ExtracellularSequence analysisAdd BLAST19
Transmembranei5980 – 6000HelicalSequence analysisAdd BLAST21
Topological domaini6001 – 6010CytoplasmicSequence analysis10
Transmembranei6011 – 6031HelicalSequence analysisAdd BLAST21
Topological domaini6032 – 6059ExtracellularSequence analysisAdd BLAST28
Transmembranei6060 – 6080HelicalSequence analysisAdd BLAST21
Topological domaini6081 – 6104CytoplasmicSequence analysisAdd BLAST24
Transmembranei6105 – 6125HelicalSequence analysisAdd BLAST21
Topological domaini6126 – 6133ExtracellularSequence analysis8
Transmembranei6134 – 6154HelicalSequence analysisAdd BLAST21
Topological domaini6155 – 6306CytoplasmicSequence analysisAdd BLAST152

GO - Cellular componenti

  • cell surface Source: HGNC
  • cytoplasm Source: HGNC
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: GDB
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
  • stereocilium Source: Ensembl
  • synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Usher syndrome 2C (USH2C)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionUSH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
See also OMIM:605472
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0680324789R → W in USH2C. 1 Publication1
Natural variantiVAR_0680335978H → R in USH2C. 1 PublicationCorresponds to variant rs756460900dbSNPEnsembl.1
Febrile seizures, familial, 4 (FEB4)
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionSeizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
See also OMIM:604352

Keywords - Diseasei

Deafness, Retinitis pigmentosa, Usher syndrome

Organism-specific databases

DisGeNETi84059.
MIMi604352. phenotype.
605472. phenotype.
OpenTargetsiENSG00000164199.
Orphaneti231178. Usher syndrome type 2.

Polymorphism and mutation databases

BioMutaiGPR98.
DMDMi327478512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000023273530 – 6306G-protein coupled receptor 98Add BLAST6277

Proteomic databases

EPDiQ8WXG9.
PaxDbiQ8WXG9.
PeptideAtlasiQ8WXG9.
PRIDEiQ8WXG9.

PTM databases

iPTMnetiQ8WXG9.
PhosphoSitePlusiQ8WXG9.

Expressioni

Tissue specificityi

Expressed at low levels in adult tissues.1 Publication

Developmental stagei

Isoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively.1 Publication

Gene expression databases

BgeeiENSG00000164199.
CleanExiHS_GPR98.
ExpressionAtlasiQ8WXG9. baseline and differential.
GenevisibleiQ8WXG9. HS.

Interactioni

Subunit structurei

Interacts with WHRN. Interacts with PDZD7.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
USH1CQ9Y6N9-43EBI-11621707,EBI-11523636
Ush1cQ9ES64-32EBI-11621707,EBI-7418919From a different organism.

Protein-protein interaction databases

BioGridi123854. 22 interactors.
IntActiQ8WXG9. 3 interactors.
MINTiMINT-8330032.
STRINGi9606.ENSP00000384582.

Structurei

3D structure databases

ProteinModelPortaliQ8WXG9.
SMRiQ8WXG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 117Calx-beta 1Sequence analysisAdd BLAST88
Domaini133 – 237Calx-beta 2Sequence analysisAdd BLAST105
Domaini262 – 362Calx-beta 31 PublicationAdd BLAST101
Domaini388 – 488Calx-beta 41 PublicationAdd BLAST101
Domaini645 – 745Calx-beta 51 PublicationAdd BLAST101
Domaini763 – 861Calx-beta 6Sequence analysisAdd BLAST99
Domaini876 – 979Calx-beta 7Sequence analysisAdd BLAST104
Domaini993 – 1093Calx-beta 8Sequence analysisAdd BLAST101
Domaini1108 – 1208Calx-beta 91 PublicationAdd BLAST101
Domaini1444 – 1544Calx-beta 101 PublicationAdd BLAST101
Domaini1564 – 1665Calx-beta 11Sequence analysisAdd BLAST102
Domaini1710 – 1809Calx-beta 12Sequence analysisAdd BLAST100
Domaini1850 – 1952Calx-beta 13Sequence analysisAdd BLAST103
Domaini1966 – 2079Calx-beta 14Sequence analysisAdd BLAST114
Domaini2107 – 2206Calx-beta 15Sequence analysisAdd BLAST100
Domaini2222 – 2324Calx-beta 16Sequence analysisAdd BLAST103
Domaini2441 – 2541Calx-beta 171 PublicationAdd BLAST101
Domaini2584 – 2676Calx-beta 18Sequence analysisAdd BLAST93
Domaini2689 – 2789Calx-beta 191 PublicationAdd BLAST101
Domaini2814 – 2925Calx-beta 20Sequence analysisAdd BLAST112
Domaini2947 – 3048Calx-beta 21Sequence analysisAdd BLAST102
Domaini3063 – 3172Calx-beta 22Sequence analysisAdd BLAST110
Repeati3189 – 3241EAR 1Add BLAST53
Repeati3296 – 3345EAR 2Add BLAST50
Repeati3347 – 3393EAR 3Add BLAST47
Repeati3394 – 3439EAR 4Add BLAST46
Repeati3440 – 3488EAR 5Add BLAST49
Repeati3491 – 3534EAR 6Add BLAST44
Domaini3525 – 3625Calx-beta 231 PublicationAdd BLAST101
Domaini3639 – 3739Calx-beta 241 PublicationAdd BLAST101
Domaini3775 – 3875Calx-beta 251 PublicationAdd BLAST101
Domaini3899 – 4006Calx-beta 26Sequence analysisAdd BLAST108
Domaini4020 – 4123Calx-beta 27Sequence analysisAdd BLAST104
Domaini4139 – 4239Calx-beta 281 PublicationAdd BLAST101
Domaini4255 – 4354Calx-beta 29Sequence analysisAdd BLAST100
Domaini4387 – 4489Calx-beta 30Sequence analysisAdd BLAST103
Domaini4512 – 4612Calx-beta 311 PublicationAdd BLAST101
Domaini4634 – 4734Calx-beta 321 PublicationAdd BLAST101
Domaini4992 – 5095Calx-beta 33Sequence analysisAdd BLAST104
Domaini5288 – 5332Calx-beta 34Sequence analysisAdd BLAST45
Domaini5368 – 5468Calx-beta 351 PublicationAdd BLAST101
Domaini5853 – 5902GPSPROSITE-ProRule annotationAdd BLAST50

Sequence similaritiesi

Contains 35 Calx-beta domains.1 PublicationCurated
Contains 6 EAR repeats.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUBQ. Eukaryota.
ENOG410XT0U. LUCA.
GeneTreeiENSGT00730000110414.
HOGENOMiHOG000088618.
HOVERGENiHBG081572.
InParanoidiQ8WXG9.
KOiK18263.
OMAiQKSDNAN.
OrthoDBiEOG091G031A.
PhylomeDBiQ8WXG9.
TreeFamiTF331149.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR003644. Calx_beta.
IPR013320. ConA-like_dom.
IPR009039. EAR.
IPR005492. EPTP.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR026919. GPR98.
IPR000203. GPS.
[Graphical view]
PANTHERiPTHR11878:SF20. PTHR11878:SF20. 8 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF03160. Calx-beta. 35 hits.
PF03736. EPTP. 1 hit.
[Graphical view]
SMARTiSM00237. Calx_beta. 19 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50912. EAR. 5 hits.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXG9-1) [UniParc]FASTAAdd to basket
Also known as: VLGR1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSVFLGPGMP SASLLVNLLS ALLILFVFGE TEIRFTGQTE FVVNETSTTV
60 70 80 90 100
IRLIIERIGE PANVTAIVSL YGEDAGDFFD TYAAAFIPAG ETNRTVYIAV
110 120 130 140 150
CDDDLPEPDE TFIFHLTLQK PSANVKLGWP RTVTVTILSN DNAFGIISFN
160 170 180 190 200
MLPSIAVSEP KGRNESMPLT LIREKGTYGM VMVTFEVEGG PNPPDEDLSP
210 220 230 240 250
VKGNITFPPG RATVIYNLTV LDDEVPENDE IFLIQLKSVE GGAEINTSRN
260 270 280 290 300
SIEIIIKKND SPVRFLQSIY LVPEEDHILI IPVVRGKDNN GNLIGSDEYE
310 320 330 340 350
VSISYAVTTG NSTAHAQQNL DFIDLQPNTT VVFPPFIHES HLKFQIVDDT
360 370 380 390 400
IPEIAESFHI MLLKDTLQGD AVLISPSVVQ VTIKPNDKPY GVLSFNSVLF
410 420 430 440 450
ERTVIIDEDR ISRYEEITVV RNGGTHGNVS ANWVLTRNST DPSPVTADIR
460 470 480 490 500
PSSGVLHFAQ GQMLATIPLT VVDDDLPEEA EAYLLQILPH TIRGGAEVSE
510 520 530 540 550
PAELLFYIQD SDDVYGLITF FPMENQKIES SPGERYLSLS FTRLGGTKGD
560 570 580 590 600
VRLLYSVLYI PAGAVDPLQA KEGILNISRR NDLIFPEQKT QVTTKLPIRN
610 620 630 640 650
DAFLQNGAHF LVQLETVELL NIIPLIPPIS PRFGEICNIS LLVTPAIANG
660 670 680 690 700
EIGFLSNLPI ILHEPEDFAA EVVYIPLHRD GTDGQATVYW SLKPSGFNSK
710 720 730 740 750
AVTPDDIGPF NGSVLFLSGQ SDTTINITIK GDDIPEMNET VTLSLDRVNV
760 770 780 790 800
ENQVLKSGYT SRDLIILEND DPGGVFEFSP ASRGPYVIKE GESVELHIIR
810 820 830 840 850
SRGSLVKQFL HYRVEPRDSN EFYGNTGVLE FKPGEREIVI TLLARLDGIP
860 870 880 890 900
ELDEHYWVVL SSHGERESKL GSATIVNITI LKNDDPHGII EFVSDGLIVM
910 920 930 940 950
INESKGDAIY SAVYDVVRNR GNFGDVSVSW VVSPDFTQDV FPVQGTVVFG
960 970 980 990 1000
DQEFSKNITI YSLPDEIPEE MEEFTVILLN GTGGAKVGNR TTATLRIRRN
1010 1020 1030 1040 1050
DDPIYFAEPR VVRVQEGETA NFTVLRNGSV DVTCMVQYAT KDGKATARER
1060 1070 1080 1090 1100
DFIPVEKGET LIFEVGSRQQ SISIFVNEDG IPETDEPFYI ILLNSTGDTV
1110 1120 1130 1140 1150
VYQYGVATVI IEANDDPNGI FSLEPIDKAV EEGKTNAFWI LRHRGYFGSV
1160 1170 1180 1190 1200
SVSWQLFQND SALQPGQEFY ETSGTVNFMD GEEAKPIILH AFPDKIPEFN
1210 1220 1230 1240 1250
EFYFLKLVNI SGGSPGPGGQ LAETNLQVTV MVPFNDDPFG VFILDPECLE
1260 1270 1280 1290 1300
REVAEDVLSE DDMSYITNFT ILRQQGVFGD VQLGWEILSS EFPAGLPPMI
1310 1320 1330 1340 1350
DFLLVGIFPT TVHLQQHMRR HHSGTDALYF TGLEGAFGTV NPKYHPSRNN
1360 1370 1380 1390 1400
TIANFTFSAW VMPNANTNGF IIAKDDGNGS IYYGVKIQTN ESHVTLSLHY
1410 1420 1430 1440 1450
KTLGSNATYI AKTTVMKYLE ESVWLHLLII LEDGIIEFYL DGNAMPRGIK
1460 1470 1480 1490 1500
SLKGEAITDG PGILRIGAGI NGNDRFTGLM QDVRSYERKL TLEEIYELHA
1510 1520 1530 1540 1550
MPAKSDLHPI SGYLEFRQGE TNKSFIISAR DDNDEEGEEL FILKLVSVYG
1560 1570 1580 1590 1600
GARISEENTT ARLTIQKSDN ANGLFGFTGA CIPEIAEEGS TISCVVERTR
1610 1620 1630 1640 1650
GALDYVHVFY TISQIETDGI NYLVDDFANA SGTITFLPWQ RSEVLNIYVL
1660 1670 1680 1690 1700
DDDIPELNEY FRVTLVSAIP GDGKLGSTPT SGASIDPEKE TTDITIKASD
1710 1720 1730 1740 1750
HPYGLLQFST GLPPQPKDAM TLPASSVPHI TVEEEDGEIR LLVIRAQGLL
1760 1770 1780 1790 1800
GRVTAEFRTV SLTAFSPEDY QNVAGTLEFQ PGERYKYIFI NITDNSIPEL
1810 1820 1830 1840 1850
EKSFKVELLN LEGGVAELFR VDGSGSGDGD MEFFLPTIHK RASLGVASQI
1860 1870 1880 1890 1900
LVTIAASDHA HGVFEFSPES LFVSGTEPED GYSTVTLNVI RHHGTLSPVT
1910 1920 1930 1940 1950
LHWNIDSDPD GDLAFTSGNI TFEIGQTSAN ITVEILPDED PELDKAFSVS
1960 1970 1980 1990 2000
VLSVSSGSLG AHINATLTVL ASDDPYGIFI FSEKNRPVKV EEATQNITLS
2010 2020 2030 2040 2050
IIRLKGLMGK VLVSYATLDD MEKPPYFPPN LARATQGRDY IPASGFALFG
2060 2070 2080 2090 2100
ANQSEATIAI SILDDDEPER SESVFIELLN STLVAKVQSR SIPNSPRLGP
2110 2120 2130 2140 2150
KVETIAQLII IANDDAFGTL QLSAPIVRVA ENHVGPIINV TRTGGAFADV
2160 2170 2180 2190 2200
SVKFKAVPIT AIAGEDYSIA SSDVVLLEGE TSKAVPIYVI NDIYPELEES
2210 2220 2230 2240 2250
FLVQLMNETT GGARLGALTE AVIIIEASDD PYGLFGFQIT KLIVEEPEFN
2260 2270 2280 2290 2300
SVKVNLPIIR NSGTLGNVTV QWVATINGQL ATGDLRVVSG NVTFAPGETI
2310 2320 2330 2340 2350
QTLLLEVLAD DVPEIEEVIQ VQLTDASGGG TIGLDRIANI IIPANDDPYG
2360 2370 2380 2390 2400
TVAFAQMVYR VQEPLERSSC ANITVRRSGG HFGRLLLFYS TSDIDVVALA
2410 2420 2430 2440 2450
MEEGQDLLSY YESPIQGVPD PLWRTWMNVS AVGEPLYTCA TLCLKEQACS
2460 2470 2480 2490 2500
AFSFFSASEG PQCFWMTSWI SPAVNNSDFW TYRKNMTRVA SLFSGQAVAG
2510 2520 2530 2540 2550
SDYEPVTRQW AIMQEGDEFA NLTVSILPDD FPEMDESFLI SLLEVHLMNI
2560 2570 2580 2590 2600
SASLKNQPTI GQPNISTVVI ALNGDAFGVF VIYNISPNTS EDGLFVEVQE
2610 2620 2630 2640 2650
QPQTLVELMI HRTGGSLGQV AVEWRVVGGT ATEGLDFIGA GEILTFAEGE
2660 2670 2680 2690 2700
TKKTVILTIL DDSEPEDDES IIVSLVYTEG GSRILPSSDT VRVNILANDN
2710 2720 2730 2740 2750
VAGIVSFQTA SRSVIGHEGE ILQFHVIRTF PGRGNVTVNW KIIGQNLELN
2760 2770 2780 2790 2800
FANFSGQLFF PEGSLNTTLF VHLLDDNIPE EKEVYQVILY DVRTQGVPPA
2810 2820 2830 2840 2850
GIALLDAQGY AAVLTVEASD EPHGVLNFAL SSRFVLLQEA NITIQLFINR
2860 2870 2880 2890 2900
EFGSLGAINV TYTTVPGMLS LKNQTVGNLA EPEVDFVPII GFLILEEGET
2910 2920 2930 2940 2950
AAAINITILE DDVPELEEYF LVNLTYVGLT MAASTSFPPR LDSEGLTAQV
2960 2970 2980 2990 3000
IIDANDGARG VIEWQQSRFE VNETHGSLTL VAQRSREPLG HVSLFVYAQN
3010 3020 3030 3040 3050
LEAQVGLDYI FTPMILHFAD GERYKNVNIM ILDDDIPEGD EKFQLILTNP
3060 3070 3080 3090 3100
SPGLELGKNT IALIIVLAND DGPGVLSFNN SEHFFLREPT ALYVQESVAV
3110 3120 3130 3140 3150
LYIVREPAQG LFGTVTVQFI VTEVNSSNES KDLTPSKGYI VLEEGVRFKA
3160 3170 3180 3190 3200
LQISAILDTE PEMDEYFVCT LFNPTGGARL GVHVQTLITV LQNQAPLGLF
3210 3220 3230 3240 3250
SISAVENRAT SIDIEEANRT VYLNVSRTNG IDLAVSVQWE TVSETAFGMR
3260 3270 3280 3290 3300
GMDVVFSVFQ SFLDESASGW CFFTLENLIY GIMLRKSSVT VYRWQGIFIP
3310 3320 3330 3340 3350
VEDLNIENPK TCEAFNIGFS PYFVITHEER NEEKPSLNSV FTFTSGFKLF
3360 3370 3380 3390 3400
LVQTIIILES SQVRYFTSDS QDYLIIASQR DDSELTQVFR WNGGSFVLHQ
3410 3420 3430 3440 3450
KLPVRGVLTV ALFNKGGSVF LAISQANARL NSLLFRWSGS GFINFQEVPV
3460 3470 3480 3490 3500
SGTTEVEALS SANDIYLIFA ENVFLGDQNS IDIFIWEMGQ SSFRYFQSVD
3510 3520 3530 3540 3550
FAAVNRIHSF TPASGIAHIL LIGQDMSALY CWNSERNQFS FVLEVPSAYD
3560 3570 3580 3590 3600
VASVTVKSLN SSKNLIALVG AHSHIYELAY ISSHSDFIPS SGELIFEPGE
3610 3620 3630 3640 3650
REATIAVNIL DDTVPEKEES FKVQLKNPKG GAEIGINDSV TITILSNDDA
3660 3670 3680 3690 3700
YGIVAFAQNS LYKQVEEMEQ DSLVTLNVER LKGTYGRITI AWEADGSISD
3710 3720 3730 3740 3750
IFPTSGVILF TEGQVLSTIT LTILADNIPE LSEVVIVTLT RITTEGVEDS
3760 3770 3780 3790 3800
YKGATIDQDR SKSVITTLPN DSPFGLVGWR AASVFIRVAE PKENTTTLQL
3810 3820 3830 3840 3850
QIARDKGLLG DIAIHLRAQP NFLLHVDNQA TENEDYVLQE TIIIMKENIK
3860 3870 3880 3890 3900
EAHAEVSILP DDLPELEEGF IVTITEVNLV NSDFSTGQPS VRRPGMEIAE
3910 3920 3930 3940 3950
IMIEENDDPR GIFMFHVTRG AGEVITAYEV PPPLNVLQVP VVRLAGSFGA
3960 3970 3980 3990 4000
VNVYWKASPD SAGLEDFKPS HGILEFADKQ VTAMIEITII DDAEFELTET
4010 4020 4030 4040 4050
FNISLISVAG GGRLGDDVVV TVVIPQNDSP FGVFGFEEKT VMIDESLSSD
4060 4070 4080 4090 4100
DPDSYVTLTV VRSPGGKGTV RLEWTIDEKA KHNLSPLNGT LHFDETESQK
4110 4120 4130 4140 4150
TIVLHTLQDT VLEEDRRFTI QLISIDEVEI SPVKGSASII IRGDKRASGE
4160 4170 4180 4190 4200
VGIAPSSRHI LIGEPSAKYN GTAIISLVRG PGILGEVTVF WRIFPPSVGE
4210 4220 4230 4240 4250
FAETSGKLTM RDEQSAVIVV IQALNDDIPE EKSFYEFQLT AVSEGGVLSE
4260 4270 4280 4290 4300
SSSTANITVV ASDSPYGRFA FSHEQLRVSE AQRVNITIIR SSGDFGHVRL
4310 4320 4330 4340 4350
WYKTMSGTAE AGLDFVPAAG ELLFEAGEMR KSLHVEILDD DYPEGPEEFS
4360 4370 4380 4390 4400
LTITKVELQG RGYDFTIQEN GLQIDQPPEI GNISIVRIII MKNDNAEGII
4410 4420 4430 4440 4450
EFDPKYTAFE VEEDVGLIMI PVVRLHGTYG YVTADFISQS SSASPGGVDY
4460 4470 4480 4490 4500
ILHGSTVTFQ HGQNLSFINI SIIDDNESEF EEPIEILLTG ATGGAVLGRH
4510 4520 4530 4540 4550
LVSRIIIAKS DSPFGVIRFL NQSKISIANP NSTMILSLVL ERTGGLLGEI
4560 4570 4580 4590 4600
QVNWETVGPN SQEALLPQNR DIADPVSGLF YFGEGEGGVR TIILTIYPHE
4610 4620 4630 4640 4650
EIEVEETFII KLHLVKGEAK LDSRAKDVTL TIQEFGDPNG VVQFAPETLS
4660 4670 4680 4690 4700
KKTYSEPLAL EGPLLITFFV RRVKGTFGEI MVYWELSSEF DITEDFLSTS
4710 4720 4730 4740 4750
GFFTIADGES EASFDVHLLP DEVPEIEEDY VIQLVSVEGG AELDLEKSIT
4760 4770 4780 4790 4800
WFSVYANDDP HGVFALYSDR QSILIGQNLI RSIQINITRL AGTFGDVAVG
4810 4820 4830 4840 4850
LRISSDHKEQ PIVTENAERQ LVVKDGATYK VDVVPIKNQV FLSLGSNFTL
4860 4870 4880 4890 4900
QLVTVMLVGG RFYGMPTILQ EAKSAVLPVS EKAANSQVGF ESTAFQLMNI
4910 4920 4930 4940 4950
TAGTSHVMIS RRGTYGALSV AWTTGYAPGL EIPEFIVVGN MTPTLGSLSF
4960 4970 4980 4990 5000
SHGEQRKGVF LWTFPSPGWP EAFVLHLSGV QSSAPGGAQL RSGFIVAEIE
5010 5020 5030 5040 5050
PMGVFQFSTS SRNIIVSEDT QMIRLHVQRL FGFHSDLIKV SYQTTAGSAK
5060 5070 5080 5090 5100
PLEDFEPVQN GELFFQKFQT EVDFEITIIN DQLSEIEEFF YINLTSVEIR
5110 5120 5130 5140 5150
GLQKFDVNWS PRLNLDFSVA VITILDNDDL AGMDISFPET TVAVAVDTTL
5160 5170 5180 5190 5200
IPVETESTTY LSTSKTTTIL QPTNVVAIVT EATGVSAIPE KLVTLHGTPA
5210 5220 5230 5240 5250
VSEKPDVATV TANVSIHGTF SLGPSIVYIE EEMKNGTFNT AEVLIRRTGG
5260 5270 5280 5290 5300
FTGNVSITVK TFGERCAQME PNALPFRGIY GISNLTWAVE EEDFEEQTLT
5310 5320 5330 5340 5350
LIFLDGERER KVSVQILDDD EPEGQEFFYV FLTNPQGGAQ IVEEKDDTGF
5360 5370 5380 5390 5400
AAFAMVIITG SDLHNGIIGF SEESQSGLEL REGAVMRRLH LIVTRQPNRA
5410 5420 5430 5440 5450
FEDVKVFWRV TLNKTVVVLQ KDGVNLVEEL QSVSGTTTCT MGQTKCFISI
5460 5470 5480 5490 5500
ELKPEKVPQV EVYFFVELYE ATAGAAINNS ARFAQIKILE SDESQSLVYF
5510 5520 5530 5540 5550
SVGSRLAVAH KKATLISLQV ARDSGTGLMM SVNFSTQELR SAETIGRTII
5560 5570 5580 5590 5600
SPAISGKDFV ITEGTLVFEP GQRSTVLDVI LTPETGSLNS FPKRFQIVLF
5610 5620 5630 5640 5650
DPKGGARIDK VYGTANITLV SDADSQAIWG LADQLHQPVN DDILNRVLHT
5660 5670 5680 5690 5700
ISMKVATENT DEQLSAMMHL IEKITTEGKI QAFSVASRTL FYEILCSLIN
5710 5720 5730 5740 5750
PKRKDTRGFS HFAEVTENFA FSLLTNVTCG SPGEKSKTIL DSCPYLSILA
5760 5770 5780 5790 5800
LHWYPQQING HKFEGKEGDY IRIPERLLDV QDAEIMAGKS TCKLVQFTEY
5810 5820 5830 5840 5850
SSQQWFISGN NLPTLKNKVL SLSVKGQSSQ LLTNDNEVLY RIYAAEPRII
5860 5870 5880 5890 5900
PQTSLCLLWN QAAASWLSDS QFCKVVEETA DYVECACSHM SVYAVYARTD
5910 5920 5930 5940 5950
NLSSYNEAFF TSGFICISGL CLAVLSHIFC ARYSMFAAKL LTHMMAASLG
5960 5970 5980 5990 6000
TQILFLASAY ASPQLAEESC SAMAAVTHYL YLCQFSWMLI QSVNFWYVLV
6010 6020 6030 6040 6050
MNDEHTERRY LLFFLLSWGL PAFVVILLIV ILKGIYHQSM SQIYGLIHGD
6060 6070 6080 6090 6100
LCFIPNVYAA LFTAALVPLT CLVVVFVVFI HAYQVKPQWK AYDDVFRGRT
6110 6120 6130 6140 6150
NAAEIPLILY LFALISVTWL WGGLHMAYRH FWMLVLFVIF NSLQGLYVFM
6160 6170 6180 6190 6200
VYFILHNQMC CPMKASYTVE MNGHPGPSTA FFTPGSGMPP AGGEISKSTQ
6210 6220 6230 6240 6250
NLIGAMEEVP PDWERASFQQ GSQASPDLKP SPQNGATFPS SGGYGQGSLI
6260 6270 6280 6290 6300
ADEESQEFDD LIFALKTGAG LSVSDNESGQ GSQEGGTLTD SQIVELRRIP

IADTHL
Length:6,306
Mass (Da):693,069
Last modified:April 5, 2011 - v2
Checksum:i30168F374ACEEF24
GO
Isoform 2 (identifier: Q8WXG9-2) [UniParc]FASTAAdd to basket
Also known as: VLGR1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-4339: Missing.
     4340-4359: DDYPEGPEEFSLTITKVELQ → MQLCIFCCCCILFYFDLYDF

Note: May be due to intron retention.
Show »
Length:1,967
Mass (Da):217,183
Checksum:iFB25C8F0D003EB47
GO
Isoform 3 (identifier: Q8WXG9-3) [UniParc]FASTAAdd to basket
Also known as: VLGR1c

The sequence of this isoform differs from the canonical sequence as follows:
     2296-2306: PGETIQTLLLE → RVVSGYPSATN
     2307-6306: Missing.

Note: Dubious isoform produced through aberrant splice sites.1 Publication
Show »
Length:2,306
Mass (Da):252,843
Checksum:i0D3B4F197CF169D8
GO
Isoform 4 (identifier: Q8WXG9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1461-1466: PGILRI → EGHHHN
     1467-6306: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:1,466
Mass (Da):162,038
Checksum:iD213A1B3948A9453
GO

Sequence cautioni

The sequence AAL30811 differs from that shown. Reason: Frameshift at positions 3524 and 3532.Curated
The sequence CAB66476 differs from that shown. Reason: Erroneous translation. Wrong genetic code use for translating the sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107E → G in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti219T → A in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti257K → E in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti435 – 437LTR → VTP in AAL30811 (PubMed:11606593).Curated3
Sequence conflicti471 – 472VV → GG in AAL30811 (PubMed:11606593).Curated2
Sequence conflicti534E → G in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti747R → W in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti1096T → P in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti1099T → P in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti1232V → A in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti1320R → G in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti1340 – 1342VNP → GNS in AAL30811 (PubMed:11606593).Curated3
Sequence conflicti1347S → F in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti3230G → D in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti3528A → T in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti3552A → V in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti4244E → G in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti5427V → M in AAD55586 (PubMed:10976914).Curated1
Sequence conflicti5427V → M in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti5427V → M in BAA31661 (PubMed:9734811).Curated1
Sequence conflicti5876V → I in AAD55586 (PubMed:10976914).Curated1
Sequence conflicti5876V → I in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti5876V → I in BAA31661 (PubMed:9734811).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025995127L → R.1 PublicationCorresponds to variant rs41311333dbSNPEnsembl.1
Natural variantiVAR_025996249R → K.1 PublicationCorresponds to variant rs41303344dbSNPEnsembl.1
Natural variantiVAR_046346551V → A.Corresponds to variant rs6889939dbSNPEnsembl.1
Natural variantiVAR_0259971093L → F.2 PublicationsCorresponds to variant rs2366777dbSNPEnsembl.1
Natural variantiVAR_0463471187I → V.Corresponds to variant rs16868935dbSNPEnsembl.1
Natural variantiVAR_0463481916T → I.Corresponds to variant rs35791889dbSNPEnsembl.1
Natural variantiVAR_0259981927T → M.1 PublicationCorresponds to variant rs17544552dbSNPEnsembl.1
Natural variantiVAR_0259991951V → I.1 PublicationCorresponds to variant rs4916684dbSNPEnsembl.1
Natural variantiVAR_0260001985N → D.1 PublicationCorresponds to variant rs41303352dbSNPEnsembl.1
Natural variantiVAR_0260011987P → L.1 PublicationCorresponds to variant rs4916685dbSNPEnsembl.1
Natural variantiVAR_0260022004L → F.1 PublicationCorresponds to variant rs16868972dbSNPEnsembl.1
Natural variantiVAR_0463492097R → C.Corresponds to variant rs16868974dbSNPEnsembl.1
Natural variantiVAR_0260032232Y → C.1 PublicationCorresponds to variant rs10037067dbSNPEnsembl.1
Natural variantiVAR_0260042345N → S.1 PublicationCorresponds to variant rs2366926dbSNPEnsembl.1
Natural variantiVAR_0260052379G → A.1 Publication1
Natural variantiVAR_0260062584N → S.2 PublicationsCorresponds to variant rs1878878dbSNPEnsembl.1
Natural variantiVAR_0260072764S → L.1 PublicationCorresponds to variant rs16869016dbSNPEnsembl.1
Natural variantiVAR_0260082803A → T.1 PublicationCorresponds to variant rs111033530dbSNPEnsembl.1
Natural variantiVAR_0463503094V → I.Corresponds to variant rs13157270dbSNPEnsembl.1
Natural variantiVAR_0260093217A → V.1 PublicationCorresponds to variant rs114137750dbSNPEnsembl.1
Natural variantiVAR_0260103248G → D.1 PublicationCorresponds to variant rs16869032dbSNPEnsembl.1
Natural variantiVAR_0463513347F → L.Corresponds to variant rs10067636dbSNPEnsembl.1
Natural variantiVAR_0260113471E → K.2 PublicationsCorresponds to variant rs2366928dbSNPEnsembl.1
Natural variantiVAR_0463523867E → A.Corresponds to variant rs16869088dbSNPEnsembl.1
Natural variantiVAR_0559333868E → A.Corresponds to variant rs16869088dbSNPEnsembl.1
Natural variantiVAR_0680324789R → W in USH2C. 1 Publication1
Natural variantiVAR_0260125344E → G.4 PublicationsCorresponds to variant rs2438374dbSNPEnsembl.1
Natural variantiVAR_0260135437T → A.Corresponds to variant rs770471921dbSNPEnsembl.1
Natural variantiVAR_0680335978H → R in USH2C. 1 PublicationCorresponds to variant rs756460900dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0179471 – 4339Missing in isoform 2. 2 PublicationsAdd BLAST4339
Alternative sequenceiVSP_0353131461 – 1466PGILRI → EGHHHN in isoform 4. 1 Publication6
Alternative sequenceiVSP_0353141467 – 6306Missing in isoform 4. 1 PublicationAdd BLAST4840
Alternative sequenceiVSP_0179482296 – 2306PGETIQTLLLE → RVVSGYPSATN in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0179492307 – 6306Missing in isoform 3. 1 PublicationAdd BLAST4000
Alternative sequenceiVSP_0179504340 – 4359DDYPE…KVELQ → MQLCIFCCCCILFYFDLYDF in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055084 mRNA. Translation: AAD55586.1.
AF435925 mRNA. Translation: AAL30811.1. Frameshift.
AC027323 Genomic DNA. No translation available.
AC034215 Genomic DNA. No translation available.
AC074132 Genomic DNA. No translation available.
AC093281 Genomic DNA. No translation available.
AC093529 Genomic DNA. No translation available.
AC094109 Genomic DNA. No translation available.
AC099512 Genomic DNA. No translation available.
AB075823 mRNA. Translation: BAB85529.1.
AL136541 mRNA. Translation: CAB66476.2. Sequence problems.
AB014586 mRNA. Translation: BAA31661.2.
CCDSiCCDS47246.1. [Q8WXG9-1]
RefSeqiNP_115495.3. NM_032119.3. [Q8WXG9-1]
UniGeneiHs.591777.

Genome annotation databases

EnsembliENST00000405460; ENSP00000384582; ENSG00000164199. [Q8WXG9-1]
ENST00000425867; ENSP00000392618; ENSG00000164199. [Q8WXG9-2]
GeneIDi84059.
KEGGihsa:84059.
UCSCiuc003kju.4. human. [Q8WXG9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055084 mRNA. Translation: AAD55586.1.
AF435925 mRNA. Translation: AAL30811.1. Frameshift.
AC027323 Genomic DNA. No translation available.
AC034215 Genomic DNA. No translation available.
AC074132 Genomic DNA. No translation available.
AC093281 Genomic DNA. No translation available.
AC093529 Genomic DNA. No translation available.
AC094109 Genomic DNA. No translation available.
AC099512 Genomic DNA. No translation available.
AB075823 mRNA. Translation: BAB85529.1.
AL136541 mRNA. Translation: CAB66476.2. Sequence problems.
AB014586 mRNA. Translation: BAA31661.2.
CCDSiCCDS47246.1. [Q8WXG9-1]
RefSeqiNP_115495.3. NM_032119.3. [Q8WXG9-1]
UniGeneiHs.591777.

3D structure databases

ProteinModelPortaliQ8WXG9.
SMRiQ8WXG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123854. 22 interactors.
IntActiQ8WXG9. 3 interactors.
MINTiMINT-8330032.
STRINGi9606.ENSP00000384582.

Protein family/group databases

TCDBi2.A.19.3.6. the ca(2+):cation antiporter (caca) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ8WXG9.
PhosphoSitePlusiQ8WXG9.

Polymorphism and mutation databases

BioMutaiGPR98.
DMDMi327478512.

Proteomic databases

EPDiQ8WXG9.
PaxDbiQ8WXG9.
PeptideAtlasiQ8WXG9.
PRIDEiQ8WXG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405460; ENSP00000384582; ENSG00000164199. [Q8WXG9-1]
ENST00000425867; ENSP00000392618; ENSG00000164199. [Q8WXG9-2]
GeneIDi84059.
KEGGihsa:84059.
UCSCiuc003kju.4. human. [Q8WXG9-1]

Organism-specific databases

CTDi84059.
DisGeNETi84059.
GeneCardsiADGRV1.
GeneReviewsiGPR98.
H-InvDBHIX0005029.
HGNCiHGNC:17416. GPR98.
MIMi602851. gene.
604352. phenotype.
605472. phenotype.
neXtProtiNX_Q8WXG9.
OpenTargetsiENSG00000164199.
Orphaneti231178. Usher syndrome type 2.
HUGEiSearch...
Search...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUBQ. Eukaryota.
ENOG410XT0U. LUCA.
GeneTreeiENSGT00730000110414.
HOGENOMiHOG000088618.
HOVERGENiHBG081572.
InParanoidiQ8WXG9.
KOiK18263.
OMAiQKSDNAN.
OrthoDBiEOG091G031A.
PhylomeDBiQ8WXG9.
TreeFamiTF331149.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164199-MONOMER.

Miscellaneous databases

ChiTaRSiGPR98. human.
GeneWikiiGPR98.
GenomeRNAii84059.
PROiQ8WXG9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164199.
CleanExiHS_GPR98.
ExpressionAtlasiQ8WXG9. baseline and differential.
GenevisibleiQ8WXG9. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR003644. Calx_beta.
IPR013320. ConA-like_dom.
IPR009039. EAR.
IPR005492. EPTP.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR026919. GPR98.
IPR000203. GPS.
[Graphical view]
PANTHERiPTHR11878:SF20. PTHR11878:SF20. 8 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF03160. Calx-beta. 35 hits.
PF03736. EPTP. 1 hit.
[Graphical view]
SMARTiSM00237. Calx_beta. 19 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50912. EAR. 5 hits.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR98_HUMAN
AccessioniPrimary (citable) accession number: Q8WXG9
Secondary accession number(s): O75171
, Q8TF58, Q9H0X5, Q9UL61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

By far is the largest known cell surface protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.