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Q8WXG9

- GPR98_HUMAN

UniProt

Q8WXG9 - GPR98_HUMAN

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Protein

G-protein coupled receptor 98

Gene
GPR98, KIAA0686, KIAA1943, MASS1, VLGR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor that may have an important role in the development of the central nervous system.

GO - Molecular functioni

  1. calcium ion binding Source: HGNC
  2. G-protein coupled receptor activity Source: UniProtKB
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
  2. G-protein coupled receptor signaling pathway Source: GDB
  3. inner ear receptor stereocilium organization Source: Ensembl
  4. maintenance of organ identity Source: HGNC
  5. nervous system development Source: UniProtKB
  6. neurological system process Source: HGNC
  7. neuropeptide signaling pathway Source: InterPro
  8. photoreceptor cell maintenance Source: HGNC
  9. sensory perception of light stimulus Source: HGNC
  10. sensory perception of sound Source: HGNC
  11. single organismal cell-cell adhesion Source: UniProtKB
  12. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium

Protein family/group databases

TCDBi2.A.19.3.6. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 98
Alternative name(s):
Monogenic audiogenic seizure susceptibility protein 1 homolog
Usher syndrome type-2C protein
Very large G-protein coupled receptor 1
Gene namesi
Name:GPR98
Synonyms:KIAA0686, KIAA1943, MASS1, VLGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:17416. GPR98.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 59085879Extracellular Reviewed predictionAdd
BLAST
Transmembranei5909 – 592921Helical; Reviewed predictionAdd
BLAST
Topological domaini5930 – 593910Cytoplasmic Reviewed prediction
Transmembranei5940 – 596021Helical; Reviewed predictionAdd
BLAST
Topological domaini5961 – 597919Extracellular Reviewed predictionAdd
BLAST
Transmembranei5980 – 600021Helical; Reviewed predictionAdd
BLAST
Topological domaini6001 – 601010Cytoplasmic Reviewed prediction
Transmembranei6011 – 603121Helical; Reviewed predictionAdd
BLAST
Topological domaini6032 – 605928Extracellular Reviewed predictionAdd
BLAST
Transmembranei6060 – 608021Helical; Reviewed predictionAdd
BLAST
Topological domaini6081 – 610424Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei6105 – 612521Helical; Reviewed predictionAdd
BLAST
Topological domaini6126 – 61338Extracellular Reviewed prediction
Transmembranei6134 – 615421Helical; Reviewed predictionAdd
BLAST
Topological domaini6155 – 6306152Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: HGNC
  2. cytoplasm Source: HGNC
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of membrane Source: GDB
  5. membrane Source: UniProtKB
  6. plasma membrane Source: UniProtKB-SubCell
  7. receptor complex Source: MGI
  8. stereocilia ankle link complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Usher syndrome 2C (USH2C) [MIM:605472]: USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4789 – 47891R → W in USH2C. 1 Publication
VAR_068032
Natural varianti5978 – 59781H → R in USH2C. 1 Publication
VAR_068033
Febrile seizures, familial, 4 (FEB4) [MIM:604352]: Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
Note: The disease may be caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Deafness, Retinitis pigmentosa, Usher syndrome

Organism-specific databases

MIMi604352. phenotype.
605472. phenotype.
Orphaneti231178. Usher syndrome type 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Chaini30 – 63066277G-protein coupled receptor 98PRO_0000232735Add
BLAST

Proteomic databases

PaxDbiQ8WXG9.
PRIDEiQ8WXG9.

PTM databases

PhosphoSiteiQ8WXG9.

Expressioni

Tissue specificityi

Expressed at low levels in adult tissues.1 Publication

Developmental stagei

Isoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively.1 Publication

Gene expression databases

ArrayExpressiQ8WXG9.
BgeeiQ8WXG9.
CleanExiHS_GPR98.
GenevestigatoriQ8WXG9.

Interactioni

Subunit structurei

Interacts with WHRN. Interacts with PDZD7.2 Publications

Protein-protein interaction databases

IntActiQ8WXG9. 1 interaction.
MINTiMINT-8330032.
STRINGi9606.ENSP00000384582.

Structurei

3D structure databases

ProteinModelPortaliQ8WXG9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 11640Calx-beta 1Add
BLAST
Domaini195 – 23541Calx-beta 2Add
BLAST
Domaini321 – 36242Calx-beta 3Add
BLAST
Domaini447 – 48842Calx-beta 4Add
BLAST
Domaini706 – 74540Calx-beta 5Add
BLAST
Domaini821 – 86141Calx-beta 6Add
BLAST
Domaini938 – 97942Calx-beta 7Add
BLAST
Domaini1051 – 109242Calx-beta 8Add
BLAST
Domaini1167 – 120842Calx-beta 9Add
BLAST
Domaini1504 – 154441Calx-beta 10Add
BLAST
Domaini1626 – 166641Calx-beta 11Add
BLAST
Domaini1767 – 180842Calx-beta 12Add
BLAST
Domaini1911 – 194131Calx-beta 13Add
BLAST
Domaini2038 – 207841Calx-beta 14Add
BLAST
Domaini2165 – 220541Calx-beta 15Add
BLAST
Domaini2283 – 232341Calx-beta 16Add
BLAST
Domaini2501 – 254141Calx-beta 17Add
BLAST
Domaini2635 – 267541Calx-beta 18Add
BLAST
Domaini2749 – 278941Calx-beta 19Add
BLAST
Domaini2884 – 292441Calx-beta 20Add
BLAST
Domaini3007 – 304741Calx-beta 21Add
BLAST
Domaini3131 – 317141Calx-beta 22Add
BLAST
Repeati3189 – 324153EAR 1Add
BLAST
Repeati3296 – 334550EAR 2Add
BLAST
Repeati3347 – 339347EAR 3Add
BLAST
Repeati3394 – 343946EAR 4Add
BLAST
Repeati3440 – 348849EAR 5Add
BLAST
Repeati3491 – 353444EAR 6Add
BLAST
Domaini3584 – 362542Calx-beta 23Add
BLAST
Domaini3700 – 373940Calx-beta 24Add
BLAST
Domaini3834 – 387542Calx-beta 25Add
BLAST
Domaini3965 – 400541Calx-beta 26Add
BLAST
Domaini4082 – 412241Calx-beta 27Add
BLAST
Domaini4199 – 423941Calx-beta 28Add
BLAST
Domaini4313 – 435341Calx-beta 29Add
BLAST
Domaini4448 – 448841Calx-beta 30Add
BLAST
Domaini4570 – 461243Calx-beta 31Add
BLAST
Domaini4693 – 473442Calx-beta 32Add
BLAST
Domaini5053 – 509442Calx-beta 33Add
BLAST
Domaini5291 – 533343Calx-beta 34Add
BLAST
Domaini5427 – 546842Calx-beta 35Add
BLAST
Domaini5853 – 590250GPSAdd
BLAST

Sequence similaritiesi

Contains 35 Calx-beta domains.
Contains 6 EAR repeats.
Contains 1 GPS domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000088618.
HOVERGENiHBG081572.
InParanoidiQ8WXG9.
KOiK18263.
OMAiNDDPFGV.
OrthoDBiEOG7DRJ24.
PhylomeDBiQ8WXG9.
TreeFamiTF331149.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR003644. Calx_beta.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR009039. EAR.
IPR005492. EPTP.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR026919. GPR98.
IPR000203. GPS.
[Graphical view]
PANTHERiPTHR11878:SF20. PTHR11878:SF20. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF03160. Calx-beta. 16 hits.
PF03736. EPTP. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
SMARTiSM00237. Calx_beta. 19 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50912. EAR. 5 hits.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WXG9-1) [UniParc]FASTAAdd to Basket

Also known as: VLGR1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MSVFLGPGMP SASLLVNLLS ALLILFVFGE TEIRFTGQTE FVVNETSTTV     50
IRLIIERIGE PANVTAIVSL YGEDAGDFFD TYAAAFIPAG ETNRTVYIAV 100
CDDDLPEPDE TFIFHLTLQK PSANVKLGWP RTVTVTILSN DNAFGIISFN 150
MLPSIAVSEP KGRNESMPLT LIREKGTYGM VMVTFEVEGG PNPPDEDLSP 200
VKGNITFPPG RATVIYNLTV LDDEVPENDE IFLIQLKSVE GGAEINTSRN 250
SIEIIIKKND SPVRFLQSIY LVPEEDHILI IPVVRGKDNN GNLIGSDEYE 300
VSISYAVTTG NSTAHAQQNL DFIDLQPNTT VVFPPFIHES HLKFQIVDDT 350
IPEIAESFHI MLLKDTLQGD AVLISPSVVQ VTIKPNDKPY GVLSFNSVLF 400
ERTVIIDEDR ISRYEEITVV RNGGTHGNVS ANWVLTRNST DPSPVTADIR 450
PSSGVLHFAQ GQMLATIPLT VVDDDLPEEA EAYLLQILPH TIRGGAEVSE 500
PAELLFYIQD SDDVYGLITF FPMENQKIES SPGERYLSLS FTRLGGTKGD 550
VRLLYSVLYI PAGAVDPLQA KEGILNISRR NDLIFPEQKT QVTTKLPIRN 600
DAFLQNGAHF LVQLETVELL NIIPLIPPIS PRFGEICNIS LLVTPAIANG 650
EIGFLSNLPI ILHEPEDFAA EVVYIPLHRD GTDGQATVYW SLKPSGFNSK 700
AVTPDDIGPF NGSVLFLSGQ SDTTINITIK GDDIPEMNET VTLSLDRVNV 750
ENQVLKSGYT SRDLIILEND DPGGVFEFSP ASRGPYVIKE GESVELHIIR 800
SRGSLVKQFL HYRVEPRDSN EFYGNTGVLE FKPGEREIVI TLLARLDGIP 850
ELDEHYWVVL SSHGERESKL GSATIVNITI LKNDDPHGII EFVSDGLIVM 900
INESKGDAIY SAVYDVVRNR GNFGDVSVSW VVSPDFTQDV FPVQGTVVFG 950
DQEFSKNITI YSLPDEIPEE MEEFTVILLN GTGGAKVGNR TTATLRIRRN 1000
DDPIYFAEPR VVRVQEGETA NFTVLRNGSV DVTCMVQYAT KDGKATARER 1050
DFIPVEKGET LIFEVGSRQQ SISIFVNEDG IPETDEPFYI ILLNSTGDTV 1100
VYQYGVATVI IEANDDPNGI FSLEPIDKAV EEGKTNAFWI LRHRGYFGSV 1150
SVSWQLFQND SALQPGQEFY ETSGTVNFMD GEEAKPIILH AFPDKIPEFN 1200
EFYFLKLVNI SGGSPGPGGQ LAETNLQVTV MVPFNDDPFG VFILDPECLE 1250
REVAEDVLSE DDMSYITNFT ILRQQGVFGD VQLGWEILSS EFPAGLPPMI 1300
DFLLVGIFPT TVHLQQHMRR HHSGTDALYF TGLEGAFGTV NPKYHPSRNN 1350
TIANFTFSAW VMPNANTNGF IIAKDDGNGS IYYGVKIQTN ESHVTLSLHY 1400
KTLGSNATYI AKTTVMKYLE ESVWLHLLII LEDGIIEFYL DGNAMPRGIK 1450
SLKGEAITDG PGILRIGAGI NGNDRFTGLM QDVRSYERKL TLEEIYELHA 1500
MPAKSDLHPI SGYLEFRQGE TNKSFIISAR DDNDEEGEEL FILKLVSVYG 1550
GARISEENTT ARLTIQKSDN ANGLFGFTGA CIPEIAEEGS TISCVVERTR 1600
GALDYVHVFY TISQIETDGI NYLVDDFANA SGTITFLPWQ RSEVLNIYVL 1650
DDDIPELNEY FRVTLVSAIP GDGKLGSTPT SGASIDPEKE TTDITIKASD 1700
HPYGLLQFST GLPPQPKDAM TLPASSVPHI TVEEEDGEIR LLVIRAQGLL 1750
GRVTAEFRTV SLTAFSPEDY QNVAGTLEFQ PGERYKYIFI NITDNSIPEL 1800
EKSFKVELLN LEGGVAELFR VDGSGSGDGD MEFFLPTIHK RASLGVASQI 1850
LVTIAASDHA HGVFEFSPES LFVSGTEPED GYSTVTLNVI RHHGTLSPVT 1900
LHWNIDSDPD GDLAFTSGNI TFEIGQTSAN ITVEILPDED PELDKAFSVS 1950
VLSVSSGSLG AHINATLTVL ASDDPYGIFI FSEKNRPVKV EEATQNITLS 2000
IIRLKGLMGK VLVSYATLDD MEKPPYFPPN LARATQGRDY IPASGFALFG 2050
ANQSEATIAI SILDDDEPER SESVFIELLN STLVAKVQSR SIPNSPRLGP 2100
KVETIAQLII IANDDAFGTL QLSAPIVRVA ENHVGPIINV TRTGGAFADV 2150
SVKFKAVPIT AIAGEDYSIA SSDVVLLEGE TSKAVPIYVI NDIYPELEES 2200
FLVQLMNETT GGARLGALTE AVIIIEASDD PYGLFGFQIT KLIVEEPEFN 2250
SVKVNLPIIR NSGTLGNVTV QWVATINGQL ATGDLRVVSG NVTFAPGETI 2300
QTLLLEVLAD DVPEIEEVIQ VQLTDASGGG TIGLDRIANI IIPANDDPYG 2350
TVAFAQMVYR VQEPLERSSC ANITVRRSGG HFGRLLLFYS TSDIDVVALA 2400
MEEGQDLLSY YESPIQGVPD PLWRTWMNVS AVGEPLYTCA TLCLKEQACS 2450
AFSFFSASEG PQCFWMTSWI SPAVNNSDFW TYRKNMTRVA SLFSGQAVAG 2500
SDYEPVTRQW AIMQEGDEFA NLTVSILPDD FPEMDESFLI SLLEVHLMNI 2550
SASLKNQPTI GQPNISTVVI ALNGDAFGVF VIYNISPNTS EDGLFVEVQE 2600
QPQTLVELMI HRTGGSLGQV AVEWRVVGGT ATEGLDFIGA GEILTFAEGE 2650
TKKTVILTIL DDSEPEDDES IIVSLVYTEG GSRILPSSDT VRVNILANDN 2700
VAGIVSFQTA SRSVIGHEGE ILQFHVIRTF PGRGNVTVNW KIIGQNLELN 2750
FANFSGQLFF PEGSLNTTLF VHLLDDNIPE EKEVYQVILY DVRTQGVPPA 2800
GIALLDAQGY AAVLTVEASD EPHGVLNFAL SSRFVLLQEA NITIQLFINR 2850
EFGSLGAINV TYTTVPGMLS LKNQTVGNLA EPEVDFVPII GFLILEEGET 2900
AAAINITILE DDVPELEEYF LVNLTYVGLT MAASTSFPPR LDSEGLTAQV 2950
IIDANDGARG VIEWQQSRFE VNETHGSLTL VAQRSREPLG HVSLFVYAQN 3000
LEAQVGLDYI FTPMILHFAD GERYKNVNIM ILDDDIPEGD EKFQLILTNP 3050
SPGLELGKNT IALIIVLAND DGPGVLSFNN SEHFFLREPT ALYVQESVAV 3100
LYIVREPAQG LFGTVTVQFI VTEVNSSNES KDLTPSKGYI VLEEGVRFKA 3150
LQISAILDTE PEMDEYFVCT LFNPTGGARL GVHVQTLITV LQNQAPLGLF 3200
SISAVENRAT SIDIEEANRT VYLNVSRTNG IDLAVSVQWE TVSETAFGMR 3250
GMDVVFSVFQ SFLDESASGW CFFTLENLIY GIMLRKSSVT VYRWQGIFIP 3300
VEDLNIENPK TCEAFNIGFS PYFVITHEER NEEKPSLNSV FTFTSGFKLF 3350
LVQTIIILES SQVRYFTSDS QDYLIIASQR DDSELTQVFR WNGGSFVLHQ 3400
KLPVRGVLTV ALFNKGGSVF LAISQANARL NSLLFRWSGS GFINFQEVPV 3450
SGTTEVEALS SANDIYLIFA ENVFLGDQNS IDIFIWEMGQ SSFRYFQSVD 3500
FAAVNRIHSF TPASGIAHIL LIGQDMSALY CWNSERNQFS FVLEVPSAYD 3550
VASVTVKSLN SSKNLIALVG AHSHIYELAY ISSHSDFIPS SGELIFEPGE 3600
REATIAVNIL DDTVPEKEES FKVQLKNPKG GAEIGINDSV TITILSNDDA 3650
YGIVAFAQNS LYKQVEEMEQ DSLVTLNVER LKGTYGRITI AWEADGSISD 3700
IFPTSGVILF TEGQVLSTIT LTILADNIPE LSEVVIVTLT RITTEGVEDS 3750
YKGATIDQDR SKSVITTLPN DSPFGLVGWR AASVFIRVAE PKENTTTLQL 3800
QIARDKGLLG DIAIHLRAQP NFLLHVDNQA TENEDYVLQE TIIIMKENIK 3850
EAHAEVSILP DDLPELEEGF IVTITEVNLV NSDFSTGQPS VRRPGMEIAE 3900
IMIEENDDPR GIFMFHVTRG AGEVITAYEV PPPLNVLQVP VVRLAGSFGA 3950
VNVYWKASPD SAGLEDFKPS HGILEFADKQ VTAMIEITII DDAEFELTET 4000
FNISLISVAG GGRLGDDVVV TVVIPQNDSP FGVFGFEEKT VMIDESLSSD 4050
DPDSYVTLTV VRSPGGKGTV RLEWTIDEKA KHNLSPLNGT LHFDETESQK 4100
TIVLHTLQDT VLEEDRRFTI QLISIDEVEI SPVKGSASII IRGDKRASGE 4150
VGIAPSSRHI LIGEPSAKYN GTAIISLVRG PGILGEVTVF WRIFPPSVGE 4200
FAETSGKLTM RDEQSAVIVV IQALNDDIPE EKSFYEFQLT AVSEGGVLSE 4250
SSSTANITVV ASDSPYGRFA FSHEQLRVSE AQRVNITIIR SSGDFGHVRL 4300
WYKTMSGTAE AGLDFVPAAG ELLFEAGEMR KSLHVEILDD DYPEGPEEFS 4350
LTITKVELQG RGYDFTIQEN GLQIDQPPEI GNISIVRIII MKNDNAEGII 4400
EFDPKYTAFE VEEDVGLIMI PVVRLHGTYG YVTADFISQS SSASPGGVDY 4450
ILHGSTVTFQ HGQNLSFINI SIIDDNESEF EEPIEILLTG ATGGAVLGRH 4500
LVSRIIIAKS DSPFGVIRFL NQSKISIANP NSTMILSLVL ERTGGLLGEI 4550
QVNWETVGPN SQEALLPQNR DIADPVSGLF YFGEGEGGVR TIILTIYPHE 4600
EIEVEETFII KLHLVKGEAK LDSRAKDVTL TIQEFGDPNG VVQFAPETLS 4650
KKTYSEPLAL EGPLLITFFV RRVKGTFGEI MVYWELSSEF DITEDFLSTS 4700
GFFTIADGES EASFDVHLLP DEVPEIEEDY VIQLVSVEGG AELDLEKSIT 4750
WFSVYANDDP HGVFALYSDR QSILIGQNLI RSIQINITRL AGTFGDVAVG 4800
LRISSDHKEQ PIVTENAERQ LVVKDGATYK VDVVPIKNQV FLSLGSNFTL 4850
QLVTVMLVGG RFYGMPTILQ EAKSAVLPVS EKAANSQVGF ESTAFQLMNI 4900
TAGTSHVMIS RRGTYGALSV AWTTGYAPGL EIPEFIVVGN MTPTLGSLSF 4950
SHGEQRKGVF LWTFPSPGWP EAFVLHLSGV QSSAPGGAQL RSGFIVAEIE 5000
PMGVFQFSTS SRNIIVSEDT QMIRLHVQRL FGFHSDLIKV SYQTTAGSAK 5050
PLEDFEPVQN GELFFQKFQT EVDFEITIIN DQLSEIEEFF YINLTSVEIR 5100
GLQKFDVNWS PRLNLDFSVA VITILDNDDL AGMDISFPET TVAVAVDTTL 5150
IPVETESTTY LSTSKTTTIL QPTNVVAIVT EATGVSAIPE KLVTLHGTPA 5200
VSEKPDVATV TANVSIHGTF SLGPSIVYIE EEMKNGTFNT AEVLIRRTGG 5250
FTGNVSITVK TFGERCAQME PNALPFRGIY GISNLTWAVE EEDFEEQTLT 5300
LIFLDGERER KVSVQILDDD EPEGQEFFYV FLTNPQGGAQ IVEEKDDTGF 5350
AAFAMVIITG SDLHNGIIGF SEESQSGLEL REGAVMRRLH LIVTRQPNRA 5400
FEDVKVFWRV TLNKTVVVLQ KDGVNLVEEL QSVSGTTTCT MGQTKCFISI 5450
ELKPEKVPQV EVYFFVELYE ATAGAAINNS ARFAQIKILE SDESQSLVYF 5500
SVGSRLAVAH KKATLISLQV ARDSGTGLMM SVNFSTQELR SAETIGRTII 5550
SPAISGKDFV ITEGTLVFEP GQRSTVLDVI LTPETGSLNS FPKRFQIVLF 5600
DPKGGARIDK VYGTANITLV SDADSQAIWG LADQLHQPVN DDILNRVLHT 5650
ISMKVATENT DEQLSAMMHL IEKITTEGKI QAFSVASRTL FYEILCSLIN 5700
PKRKDTRGFS HFAEVTENFA FSLLTNVTCG SPGEKSKTIL DSCPYLSILA 5750
LHWYPQQING HKFEGKEGDY IRIPERLLDV QDAEIMAGKS TCKLVQFTEY 5800
SSQQWFISGN NLPTLKNKVL SLSVKGQSSQ LLTNDNEVLY RIYAAEPRII 5850
PQTSLCLLWN QAAASWLSDS QFCKVVEETA DYVECACSHM SVYAVYARTD 5900
NLSSYNEAFF TSGFICISGL CLAVLSHIFC ARYSMFAAKL LTHMMAASLG 5950
TQILFLASAY ASPQLAEESC SAMAAVTHYL YLCQFSWMLI QSVNFWYVLV 6000
MNDEHTERRY LLFFLLSWGL PAFVVILLIV ILKGIYHQSM SQIYGLIHGD 6050
LCFIPNVYAA LFTAALVPLT CLVVVFVVFI HAYQVKPQWK AYDDVFRGRT 6100
NAAEIPLILY LFALISVTWL WGGLHMAYRH FWMLVLFVIF NSLQGLYVFM 6150
VYFILHNQMC CPMKASYTVE MNGHPGPSTA FFTPGSGMPP AGGEISKSTQ 6200
NLIGAMEEVP PDWERASFQQ GSQASPDLKP SPQNGATFPS SGGYGQGSLI 6250
ADEESQEFDD LIFALKTGAG LSVSDNESGQ GSQEGGTLTD SQIVELRRIP 6300
IADTHL 6306
Length:6,306
Mass (Da):693,069
Last modified:April 5, 2011 - v2
Checksum:i30168F374ACEEF24
GO
Isoform 2 (identifier: Q8WXG9-2) [UniParc]FASTAAdd to Basket

Also known as: VLGR1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-4339: Missing.
     4340-4359: DDYPEGPEEFSLTITKVELQ → MQLCIFCCCCILFYFDLYDF

Show »
Length:1,967
Mass (Da):217,183
Checksum:iFB25C8F0D003EB47
GO
Isoform 3 (identifier: Q8WXG9-3) [UniParc]FASTAAdd to Basket

Also known as: VLGR1c

The sequence of this isoform differs from the canonical sequence as follows:
     2296-2306: PGETIQTLLLE → RVVSGYPSATN
     2307-6306: Missing.

Show »
Length:2,306
Mass (Da):252,843
Checksum:i0D3B4F197CF169D8
GO
Isoform 4 (identifier: Q8WXG9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1461-1466: PGILRI → EGHHHN
     1467-6306: Missing.

Note: No experimental confirmation available.

Show »
Length:1,466
Mass (Da):162,038
Checksum:iD213A1B3948A9453
GO

Sequence cautioni

The sequence AAL30811.1 differs from that shown. Reason: Frameshift at positions 3524 and 3532.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti127 – 1271L → R.1 Publication
Corresponds to variant rs41311333 [ dbSNP | Ensembl ].
VAR_025995
Natural varianti249 – 2491R → K.1 Publication
Corresponds to variant rs41303344 [ dbSNP | Ensembl ].
VAR_025996
Natural varianti551 – 5511V → A.
Corresponds to variant rs6889939 [ dbSNP | Ensembl ].
VAR_046346
Natural varianti1093 – 10931L → F.2 Publications
Corresponds to variant rs2366777 [ dbSNP | Ensembl ].
VAR_025997
Natural varianti1187 – 11871I → V.
Corresponds to variant rs16868935 [ dbSNP | Ensembl ].
VAR_046347
Natural varianti1916 – 19161T → I.
Corresponds to variant rs35791889 [ dbSNP | Ensembl ].
VAR_046348
Natural varianti1927 – 19271T → M.1 Publication
Corresponds to variant rs17544552 [ dbSNP | Ensembl ].
VAR_025998
Natural varianti1951 – 19511V → I.1 Publication
Corresponds to variant rs4916684 [ dbSNP | Ensembl ].
VAR_025999
Natural varianti1985 – 19851N → D.1 Publication
Corresponds to variant rs41303352 [ dbSNP | Ensembl ].
VAR_026000
Natural varianti1987 – 19871P → L.1 Publication
Corresponds to variant rs4916685 [ dbSNP | Ensembl ].
VAR_026001
Natural varianti2004 – 20041L → F.1 Publication
Corresponds to variant rs16868972 [ dbSNP | Ensembl ].
VAR_026002
Natural varianti2097 – 20971R → C.
Corresponds to variant rs16868974 [ dbSNP | Ensembl ].
VAR_046349
Natural varianti2232 – 22321Y → C.1 Publication
Corresponds to variant rs10037067 [ dbSNP | Ensembl ].
VAR_026003
Natural varianti2345 – 23451N → S.1 Publication
Corresponds to variant rs2366926 [ dbSNP | Ensembl ].
VAR_026004
Natural varianti2379 – 23791G → A.1 Publication
VAR_026005
Natural varianti2584 – 25841N → S.2 Publications
Corresponds to variant rs1878878 [ dbSNP | Ensembl ].
VAR_026006
Natural varianti2764 – 27641S → L.1 Publication
Corresponds to variant rs16869016 [ dbSNP | Ensembl ].
VAR_026007
Natural varianti2803 – 28031A → T.1 Publication
Corresponds to variant rs111033530 [ dbSNP | Ensembl ].
VAR_026008
Natural varianti3094 – 30941V → I.
Corresponds to variant rs13157270 [ dbSNP | Ensembl ].
VAR_046350
Natural varianti3217 – 32171A → V.1 Publication
Corresponds to variant rs114137750 [ dbSNP | Ensembl ].
VAR_026009
Natural varianti3248 – 32481G → D.1 Publication
Corresponds to variant rs16869032 [ dbSNP | Ensembl ].
VAR_026010
Natural varianti3347 – 33471F → L.
Corresponds to variant rs10067636 [ dbSNP | Ensembl ].
VAR_046351
Natural varianti3471 – 34711E → K.2 Publications
Corresponds to variant rs2366928 [ dbSNP | Ensembl ].
VAR_026011
Natural varianti3867 – 38671E → A.
Corresponds to variant rs16869088 [ dbSNP | Ensembl ].
VAR_046352
Natural varianti3868 – 38681E → A.
Corresponds to variant rs16869088 [ dbSNP | Ensembl ].
VAR_055933
Natural varianti4789 – 47891R → W in USH2C. 1 Publication
VAR_068032
Natural varianti5344 – 53441E → G.4 Publications
Corresponds to variant rs2438374 [ dbSNP | Ensembl ].
VAR_026012
Natural varianti5437 – 54371T → A.
VAR_026013
Natural varianti5978 – 59781H → R in USH2C. 1 Publication
VAR_068033

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 43394339Missing in isoform 2. VSP_017947Add
BLAST
Alternative sequencei1461 – 14666PGILRI → EGHHHN in isoform 4. VSP_035313
Alternative sequencei1467 – 63064840Missing in isoform 4. VSP_035314Add
BLAST
Alternative sequencei2296 – 230611PGETIQTLLLE → RVVSGYPSATN in isoform 3. VSP_017948Add
BLAST
Alternative sequencei2307 – 63064000Missing in isoform 3. VSP_017949Add
BLAST
Alternative sequencei4340 – 435920DDYPE…KVELQ → MQLCIFCCCCILFYFDLYDF in isoform 2. VSP_017950Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071E → G in AAL30811. 1 Publication
Sequence conflicti219 – 2191T → A in AAL30811. 1 Publication
Sequence conflicti257 – 2571K → E in AAL30811. 1 Publication
Sequence conflicti435 – 4373LTR → VTP in AAL30811. 1 Publication
Sequence conflicti471 – 4722VV → GG in AAL30811. 1 Publication
Sequence conflicti534 – 5341E → G in AAL30811. 1 Publication
Sequence conflicti747 – 7471R → W in AAL30811. 1 Publication
Sequence conflicti1096 – 10961T → P in AAL30811. 1 Publication
Sequence conflicti1099 – 10991T → P in AAL30811. 1 Publication
Sequence conflicti1232 – 12321V → A in AAL30811. 1 Publication
Sequence conflicti1320 – 13201R → G in AAL30811. 1 Publication
Sequence conflicti1340 – 13423VNP → GNS in AAL30811. 1 Publication
Sequence conflicti1347 – 13471S → F in AAL30811. 1 Publication
Sequence conflicti3230 – 32301G → D in AAL30811. 1 Publication
Sequence conflicti3528 – 35281A → T in AAL30811. 1 Publication
Sequence conflicti3552 – 35521A → V in AAL30811. 1 Publication
Sequence conflicti4244 – 42441E → G in AAL30811. 1 Publication
Sequence conflicti5427 – 54271V → M in AAD55586. 1 Publication
Sequence conflicti5427 – 54271V → M in AAL30811. 1 Publication
Sequence conflicti5427 – 54271V → M in BAA31661. 1 Publication
Sequence conflicti5876 – 58761V → I in AAD55586. 1 Publication
Sequence conflicti5876 – 58761V → I in AAL30811. 1 Publication
Sequence conflicti5876 – 58761V → I in BAA31661. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF055084 mRNA. Translation: AAD55586.1.
AF435925 mRNA. Translation: AAL30811.1. Frameshift.
AC027323 Genomic DNA. No translation available.
AC034215 Genomic DNA. No translation available.
AC074132 Genomic DNA. No translation available.
AC093281 Genomic DNA. No translation available.
AC093529 Genomic DNA. No translation available.
AC094109 Genomic DNA. No translation available.
AC099512 Genomic DNA. No translation available.
AB075823 mRNA. Translation: BAB85529.1.
AL136541 mRNA. Translation: CAB66476.2. Sequence problems.
AB014586 mRNA. Translation: BAA31661.2.
CCDSiCCDS47246.1. [Q8WXG9-1]
RefSeqiNP_115495.3. NM_032119.3. [Q8WXG9-1]
UniGeneiHs.591777.

Genome annotation databases

EnsembliENST00000405460; ENSP00000384582; ENSG00000164199. [Q8WXG9-1]
ENST00000425867; ENSP00000392618; ENSG00000164199. [Q8WXG9-2]
GeneIDi84059.
KEGGihsa:84059.
UCSCiuc003kju.3. human. [Q8WXG9-1]
uc003kjw.3. human. [Q8WXG9-2]

Polymorphism databases

DMDMi327478512.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF055084 mRNA. Translation: AAD55586.1 .
AF435925 mRNA. Translation: AAL30811.1 . Frameshift.
AC027323 Genomic DNA. No translation available.
AC034215 Genomic DNA. No translation available.
AC074132 Genomic DNA. No translation available.
AC093281 Genomic DNA. No translation available.
AC093529 Genomic DNA. No translation available.
AC094109 Genomic DNA. No translation available.
AC099512 Genomic DNA. No translation available.
AB075823 mRNA. Translation: BAB85529.1 .
AL136541 mRNA. Translation: CAB66476.2 . Sequence problems.
AB014586 mRNA. Translation: BAA31661.2 .
CCDSi CCDS47246.1. [Q8WXG9-1 ]
RefSeqi NP_115495.3. NM_032119.3. [Q8WXG9-1 ]
UniGenei Hs.591777.

3D structure databases

ProteinModelPortali Q8WXG9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8WXG9. 1 interaction.
MINTi MINT-8330032.
STRINGi 9606.ENSP00000384582.

Protein family/group databases

TCDBi 2.A.19.3.6. the ca(2+):cation antiporter (caca) family.
GPCRDBi Search...

PTM databases

PhosphoSitei Q8WXG9.

Polymorphism databases

DMDMi 327478512.

Proteomic databases

PaxDbi Q8WXG9.
PRIDEi Q8WXG9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000405460 ; ENSP00000384582 ; ENSG00000164199 . [Q8WXG9-1 ]
ENST00000425867 ; ENSP00000392618 ; ENSG00000164199 . [Q8WXG9-2 ]
GeneIDi 84059.
KEGGi hsa:84059.
UCSCi uc003kju.3. human. [Q8WXG9-1 ]
uc003kjw.3. human. [Q8WXG9-2 ]

Organism-specific databases

CTDi 84059.
GeneCardsi GC05P089891.
GeneReviewsi GPR98.
H-InvDB HIX0005029.
HGNCi HGNC:17416. GPR98.
MIMi 602851. gene.
604352. phenotype.
605472. phenotype.
neXtProti NX_Q8WXG9.
Orphaneti 231178. Usher syndrome type 2.
HUGEi Search...
Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000088618.
HOVERGENi HBG081572.
InParanoidi Q8WXG9.
KOi K18263.
OMAi NDDPFGV.
OrthoDBi EOG7DRJ24.
PhylomeDBi Q8WXG9.
TreeFami TF331149.

Miscellaneous databases

ChiTaRSi GPR98. human.
GeneWikii GPR98.
GenomeRNAii 84059.
NextBioi 73207.
PROi Q8WXG9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WXG9.
Bgeei Q8WXG9.
CleanExi HS_GPR98.
Genevestigatori Q8WXG9.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR003644. Calx_beta.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR009039. EAR.
IPR005492. EPTP.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR026919. GPR98.
IPR000203. GPS.
[Graphical view ]
PANTHERi PTHR11878:SF20. PTHR11878:SF20. 1 hit.
Pfami PF00002. 7tm_2. 1 hit.
PF03160. Calx-beta. 16 hits.
PF03736. EPTP. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
SMARTi SM00237. Calx_beta. 19 hits.
SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50912. EAR. 5 hits.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain."
    Nikkila H., McMillan D.R., Nunez B.S., Pascoe L., Curnow K.M., White P.C.
    Mol. Endocrinol. 14:1351-1364(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLY-5344, TISSUE SPECIFICITY.
  2. "Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system."
    McMillan D.R., Kayes-Wandover K.M., Richardson J.A., White P.C.
    J. Biol. Chem. 277:785-792(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLY-5344, DEVELOPMENTAL STAGE.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 413-6306 (ISOFORM 4), VARIANT PHE-1093.
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2436-4042 (ISOFORM 1), VARIANTS SER-2584 AND LYS-3471.
    Tissue: Amygdala.
  6. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5107-6306 (ISOFORMS 1/2), VARIANT GLY-5344.
    Tissue: Brain.
  7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  8. "The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1."
    van Wijk E., van der Zwaag B., Peters T., Zimmermann U., Te Brinke H., Kersten F.F.J., Maerker T., Aller E., Hoefsloot L.H., Cremers C.W.R.J., Cremers F.P.M., Wolfrum U., Knipper M., Roepman R., Kremer H.
    Hum. Mol. Genet. 15:751-765(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WHRN.
  9. "A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures."
    Nakayama J., Fu Y.H., Clark A.M., Nakahara S., Hamano K., Iwasaki N., Matsui A., Arinami T., Ptacek L.J.
    Ann. Neurol. 52:654-657(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN FAMILIAL FEBRILE CONVULSIONS 4.
  10. "Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II."
    Weston M.D., Luijendijk M.W.J., Humphrey K.D., Moeller C., Kimberling W.J.
    Am. J. Hum. Genet. 74:357-366(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN USH2C, VARIANTS ARG-127; LYS-249; PHE-1093; MET-1927; ILE-1951; ASP-1985; LEU-1987; PHE-2004; CYS-2232; SER-2345; ALA-2379; SER-2584; LEU-2764; THR-2803; VAL-3217; ASP-3248; LYS-3471 AND GLY-5344.
  11. Cited for: INTERACTION WITH PDZD7.
  12. Cited for: VARIANTS USH2C TRP-4789 AND ARG-5978.

Entry informationi

Entry nameiGPR98_HUMAN
AccessioniPrimary (citable) accession number: Q8WXG9
Secondary accession number(s): O75171
, Q8TF58, Q9H0X5, Q9UL61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

By far is the largest known cell surface protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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