Q8WXG9 (GPR98_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled receptor 98

Alternative name(s):
Monogenic audiogenic seizure susceptibility protein 1 homolog
Usher syndrome type-2C protein
Very large G-protein coupled receptor 1

Gene names

Name:	GPR98
Synonyms:	KIAA0686, KIAA1943, MASS1, VLGR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	6306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor that may have an important role in the development of the central nervous system.
Subunit structure	Interacts with WHRN. Interacts with PDZD7. Ref.8 Ref.11
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed at low levels in adult tissues. Ref.1
Developmental stage	Isoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively. Ref.2
Involvement in disease	Usher syndrome 2C (USH2C) [MIM:605472]: USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.12 Familial febrile convulsions 4 (FEB4) [MIM:604352]: Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. Note: The disease may be caused by mutations affecting the gene represented in this entry.
Miscellaneous	By far is the largest known cell surface protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 35 Calx-beta domains. Contains 6 EAR repeats. Contains 1 GPS domain.
Sequence caution	The sequence AAL30811.1 differs from that shown. Reason: Frameshift at positions 3524 and 3532. The sequence CAB66476.2 differs from that shown. Reason: Erroneous translation. Wrong genetic code use for translating the sequence.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Deafness Retinitis pigmentosa Usher syndrome
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell adhesion Non-traceable author statement Ref.2. Source: UniProtKB detection of mechanical stimulus involved in sensory perception of sound Inferred from electronic annotation. Source: Compara inner ear receptor stereocilium organization Inferred from electronic annotation. Source: Compara maintenance of organ identity Inferred from mutant phenotype PubMed 15671307. Source: HGNC nervous system development Non-traceable author statement Ref.2. Source: UniProtKB neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro photoreceptor cell maintenance Inferred from mutant phenotype Ref.10. Source: HGNC sensory perception of sound Inferred from mutant phenotype Ref.10. Source: HGNC
Cellular_component	cell surface Inferred from direct assay Ref.1. Source: HGNC cytoplasm Inferred from direct assay Ref.8. Source: HGNC integral to membrane Traceable author statement PubMed 15203201. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell stereocilia ankle link complex Inferred from electronic annotation. Source: Compara
Molecular_function	G-protein coupled receptor activity Non-traceable author statement Ref.2. Source: UniProtKB calcium ion binding Inferred from direct assay Ref.1. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WXG9-1)

Also known as: VLGR1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WXG9-2)

Also known as: VLGR1a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-4339: Missing.
     4340-4359: DDYPEGPEEFSLTITKVELQ → MQLCIFCCCCILFYFDLYDF

Isoform 3 (identifier: Q8WXG9-3)

Also known as: VLGR1c;

The sequence of this isoform differs from the canonical sequence as follows:
     2296-2306: PGETIQTLLLE → RVVSGYPSATN
     2307-6306: Missing.

Isoform 4 (identifier: Q8WXG9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1461-1466: PGILRI → EGHHHN
     1467-6306: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 6306	6277	G-protein coupled receptor 98		PRO_0000232735
Regions
	Topological domain	30 – 5908	5879	Extracellular Potential
	Transmembrane	5909 – 5929	21	Helical; Potential
	Topological domain	5930 – 5939	10	Cytoplasmic Potential
	Transmembrane	5940 – 5960	21	Helical; Potential
	Topological domain	5961 – 5979	19	Extracellular Potential
	Transmembrane	5980 – 6000	21	Helical; Potential
	Topological domain	6001 – 6010	10	Cytoplasmic Potential
	Transmembrane	6011 – 6031	21	Helical; Potential
	Topological domain	6032 – 6059	28	Extracellular Potential
	Transmembrane	6060 – 6080	21	Helical; Potential
	Topological domain	6081 – 6104	24	Cytoplasmic Potential
	Transmembrane	6105 – 6125	21	Helical; Potential
	Topological domain	6126 – 6133	8	Extracellular Potential
	Transmembrane	6134 – 6154	21	Helical; Potential
	Topological domain	6155 – 6306	152	Cytoplasmic Potential
	Domain	77 – 116	40	Calx-beta 1
	Domain	195 – 235	41	Calx-beta 2
	Domain	321 – 362	42	Calx-beta 3
	Domain	447 – 488	42	Calx-beta 4
	Domain	706 – 745	40	Calx-beta 5
	Domain	821 – 861	41	Calx-beta 6
	Domain	938 – 979	42	Calx-beta 7
	Domain	1051 – 1092	42	Calx-beta 8
	Domain	1167 – 1208	42	Calx-beta 9
	Domain	1504 – 1544	41	Calx-beta 10
	Domain	1626 – 1666	41	Calx-beta 11
	Domain	1767 – 1808	42	Calx-beta 12
	Domain	1911 – 1941	31	Calx-beta 13
	Domain	2038 – 2078	41	Calx-beta 14
	Domain	2165 – 2205	41	Calx-beta 15
	Domain	2283 – 2323	41	Calx-beta 16
	Domain	2501 – 2541	41	Calx-beta 17
	Domain	2635 – 2675	41	Calx-beta 18
	Domain	2749 – 2789	41	Calx-beta 19
	Domain	2884 – 2924	41	Calx-beta 20
	Domain	3007 – 3047	41	Calx-beta 21
	Domain	3131 – 3171	41	Calx-beta 22
	Repeat	3189 – 3241	53	EAR 1
	Repeat	3296 – 3345	50	EAR 2
	Repeat	3347 – 3393	47	EAR 3
	Repeat	3394 – 3439	46	EAR 4
	Repeat	3440 – 3488	49	EAR 5
	Repeat	3491 – 3534	44	EAR 6
	Domain	3584 – 3625	42	Calx-beta 23
	Domain	3700 – 3739	40	Calx-beta 24
	Domain	3834 – 3875	42	Calx-beta 25
	Domain	3965 – 4005	41	Calx-beta 26
	Domain	4082 – 4122	41	Calx-beta 27
	Domain	4199 – 4239	41	Calx-beta 28
	Domain	4313 – 4353	41	Calx-beta 29
	Domain	4448 – 4488	41	Calx-beta 30
	Domain	4570 – 4612	43	Calx-beta 31
	Domain	4693 – 4734	42	Calx-beta 32
	Domain	5053 – 5094	42	Calx-beta 33
	Domain	5291 – 5333	43	Calx-beta 34
	Domain	5427 – 5468	42	Calx-beta 35
	Domain	5853 – 5902	50	GPS
Natural variations
	Alternative sequence	1 – 4339	4339	Missing in isoform 2.		VSP_017947
	Alternative sequence	1461 – 1466	6	PGILRI → EGHHHN in isoform 4.		VSP_035313
	Alternative sequence	1467 – 6306	4840	Missing in isoform 4.		VSP_035314
	Alternative sequence	2296 – 2306	11	PGETIQTLLLE → RVVSGYPSATN in isoform 3.		VSP_017948
	Alternative sequence	2307 – 6306	4000	Missing in isoform 3.		VSP_017949
	Alternative sequence	4340 – 4359	20	DDYPE…KVELQ → MQLCIFCCCCILFYFDLYDF in isoform 2.		VSP_017950
	Natural variant	127	1	L → R. Ref.10 Corresponds to variant rs41311333 [ dbSNP | Ensembl ].		VAR_025995
	Natural variant	249	1	R → K. Ref.10 Corresponds to variant rs41303344 [ dbSNP | Ensembl ].		VAR_025996
	Natural variant	551	1	V → A. Corresponds to variant rs6889939 [ dbSNP | Ensembl ].		VAR_046346
	Natural variant	1093	1	L → F. Ref.4 Ref.10 Corresponds to variant rs2366777 [ dbSNP | Ensembl ].		VAR_025997
	Natural variant	1187	1	I → V. Corresponds to variant rs16868935 [ dbSNP | Ensembl ].		VAR_046347
	Natural variant	1916	1	T → I. Corresponds to variant rs35791889 [ dbSNP | Ensembl ].		VAR_046348
	Natural variant	1927	1	T → M. Ref.10 Corresponds to variant rs17544552 [ dbSNP | Ensembl ].		VAR_025998
	Natural variant	1951	1	V → I. Ref.10 Corresponds to variant rs4916684 [ dbSNP | Ensembl ].		VAR_025999
	Natural variant	1985	1	N → D. Ref.10 Corresponds to variant rs41303352 [ dbSNP | Ensembl ].		VAR_026000
	Natural variant	1987	1	P → L. Ref.10 Corresponds to variant rs4916685 [ dbSNP | Ensembl ].		VAR_026001
	Natural variant	2004	1	L → F. Ref.10 Corresponds to variant rs16868972 [ dbSNP | Ensembl ].		VAR_026002
	Natural variant	2097	1	R → C. Corresponds to variant rs16868974 [ dbSNP | Ensembl ].		VAR_046349
	Natural variant	2232	1	Y → C. Ref.10 Corresponds to variant rs10037067 [ dbSNP | Ensembl ].		VAR_026003
	Natural variant	2345	1	N → S. Ref.10 Corresponds to variant rs2366926 [ dbSNP | Ensembl ].		VAR_026004
	Natural variant	2379	1	G → A. Ref.10		VAR_026005
	Natural variant	2584	1	N → S. Ref.5 Ref.10 Corresponds to variant rs1878878 [ dbSNP | Ensembl ].		VAR_026006
	Natural variant	2764	1	S → L. Ref.10 Corresponds to variant rs16869016 [ dbSNP | Ensembl ].		VAR_026007
	Natural variant	2803	1	A → T. Ref.10		VAR_026008
	Natural variant	3094	1	V → I. Corresponds to variant rs13157270 [ dbSNP | Ensembl ].		VAR_046350
	Natural variant	3217	1	A → V. Ref.10		VAR_026009
	Natural variant	3248	1	G → D. Ref.10 Corresponds to variant rs16869032 [ dbSNP | Ensembl ].		VAR_026010
	Natural variant	3347	1	F → L. Corresponds to variant rs10067636 [ dbSNP | Ensembl ].		VAR_046351
	Natural variant	3471	1	E → K. Ref.5 Ref.10 Corresponds to variant rs2366928 [ dbSNP | Ensembl ].		VAR_026011
	Natural variant	3867	1	E → A. Corresponds to variant rs16869088 [ dbSNP | Ensembl ].		VAR_046352
	Natural variant	3868	1	E → A. Corresponds to variant rs16869088 [ dbSNP | Ensembl ].		VAR_055933
	Natural variant	4789	1	R → W in USH2C. Ref.12		VAR_068032
	Natural variant	5344	1	E → G. Ref.1 Ref.2 Ref.6 Ref.10		VAR_026012
	Natural variant	5437	1	T → A.		VAR_026013
	Natural variant	5978	1	H → R in USH2C. Ref.12		VAR_068033
Experimental info
	Sequence conflict	107	1	E → G in AAL30811. Ref.2
	Sequence conflict	219	1	T → A in AAL30811. Ref.2
	Sequence conflict	257	1	K → E in AAL30811. Ref.2
	Sequence conflict	435 – 437	3	LTR → VTP in AAL30811. Ref.2
	Sequence conflict	471 – 472	2	VV → GG in AAL30811. Ref.2
	Sequence conflict	534	1	E → G in AAL30811. Ref.2
	Sequence conflict	747	1	R → W in AAL30811. Ref.2
	Sequence conflict	1096	1	T → P in AAL30811. Ref.2
	Sequence conflict	1099	1	T → P in AAL30811. Ref.2
	Sequence conflict	1232	1	V → A in AAL30811. Ref.2
	Sequence conflict	1320	1	R → G in AAL30811. Ref.2
	Sequence conflict	1340 – 1342	3	VNP → GNS in AAL30811. Ref.2
	Sequence conflict	1347	1	S → F in AAL30811. Ref.2
	Sequence conflict	3230	1	G → D in AAL30811. Ref.2
	Sequence conflict	3528	1	A → T in AAL30811. Ref.2
	Sequence conflict	3552	1	A → V in AAL30811. Ref.2
	Sequence conflict	4244	1	E → G in AAL30811. Ref.2
	Sequence conflict	5427	1	V → M in AAD55586. Ref.1
	Sequence conflict	5427	1	V → M in AAL30811. Ref.2
	Sequence conflict	5427	1	V → M in BAA31661. Ref.6
	Sequence conflict	5876	1	V → I in AAD55586. Ref.1
	Sequence conflict	5876	1	V → I in AAL30811. Ref.2
	Sequence conflict	5876	1	V → I in BAA31661. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (VLGR1b) [UniParc]. Last modified April 5, 2011. Version 2. Checksum: 30168F374ACEEF24	FASTA	6,306	693,069
	10 20 30 40 50 60 MSVFLGPGMP SASLLVNLLS ALLILFVFGE TEIRFTGQTE FVVNETSTTV IRLIIERIGE 70 80 90 100 110 120 PANVTAIVSL YGEDAGDFFD TYAAAFIPAG ETNRTVYIAV CDDDLPEPDE TFIFHLTLQK 130 140 150 160 170 180 PSANVKLGWP RTVTVTILSN DNAFGIISFN MLPSIAVSEP KGRNESMPLT LIREKGTYGM 190 200 210 220 230 240 VMVTFEVEGG PNPPDEDLSP VKGNITFPPG RATVIYNLTV LDDEVPENDE IFLIQLKSVE 250 260 270 280 290 300 GGAEINTSRN SIEIIIKKND SPVRFLQSIY LVPEEDHILI IPVVRGKDNN GNLIGSDEYE 310 320 330 340 350 360 VSISYAVTTG NSTAHAQQNL DFIDLQPNTT VVFPPFIHES HLKFQIVDDT IPEIAESFHI 370 380 390 400 410 420 MLLKDTLQGD AVLISPSVVQ VTIKPNDKPY GVLSFNSVLF ERTVIIDEDR ISRYEEITVV 430 440 450 460 470 480 RNGGTHGNVS ANWVLTRNST DPSPVTADIR PSSGVLHFAQ GQMLATIPLT VVDDDLPEEA 490 500 510 520 530 540 EAYLLQILPH TIRGGAEVSE PAELLFYIQD SDDVYGLITF FPMENQKIES SPGERYLSLS 550 560 570 580 590 600 FTRLGGTKGD VRLLYSVLYI PAGAVDPLQA KEGILNISRR NDLIFPEQKT QVTTKLPIRN 610 620 630 640 650 660 DAFLQNGAHF LVQLETVELL NIIPLIPPIS PRFGEICNIS LLVTPAIANG EIGFLSNLPI 670 680 690 700 710 720 ILHEPEDFAA EVVYIPLHRD GTDGQATVYW SLKPSGFNSK AVTPDDIGPF NGSVLFLSGQ 730 740 750 760 770 780 SDTTINITIK GDDIPEMNET VTLSLDRVNV ENQVLKSGYT SRDLIILEND DPGGVFEFSP 790 800 810 820 830 840 ASRGPYVIKE GESVELHIIR SRGSLVKQFL HYRVEPRDSN EFYGNTGVLE FKPGEREIVI 850 860 870 880 890 900 TLLARLDGIP ELDEHYWVVL SSHGERESKL GSATIVNITI LKNDDPHGII EFVSDGLIVM 910 920 930 940 950 960 INESKGDAIY SAVYDVVRNR GNFGDVSVSW VVSPDFTQDV FPVQGTVVFG DQEFSKNITI 970 980 990 1000 1010 1020 YSLPDEIPEE MEEFTVILLN GTGGAKVGNR TTATLRIRRN DDPIYFAEPR VVRVQEGETA 1030 1040 1050 1060 1070 1080 NFTVLRNGSV DVTCMVQYAT KDGKATARER DFIPVEKGET LIFEVGSRQQ SISIFVNEDG 1090 1100 1110 1120 1130 1140 IPETDEPFYI ILLNSTGDTV VYQYGVATVI IEANDDPNGI FSLEPIDKAV EEGKTNAFWI 1150 1160 1170 1180 1190 1200 LRHRGYFGSV SVSWQLFQND SALQPGQEFY ETSGTVNFMD GEEAKPIILH AFPDKIPEFN 1210 1220 1230 1240 1250 1260 EFYFLKLVNI SGGSPGPGGQ LAETNLQVTV MVPFNDDPFG VFILDPECLE REVAEDVLSE 1270 1280 1290 1300 1310 1320 DDMSYITNFT ILRQQGVFGD VQLGWEILSS EFPAGLPPMI DFLLVGIFPT TVHLQQHMRR 1330 1340 1350 1360 1370 1380 HHSGTDALYF TGLEGAFGTV NPKYHPSRNN TIANFTFSAW VMPNANTNGF IIAKDDGNGS 1390 1400 1410 1420 1430 1440 IYYGVKIQTN ESHVTLSLHY KTLGSNATYI AKTTVMKYLE ESVWLHLLII LEDGIIEFYL 1450 1460 1470 1480 1490 1500 DGNAMPRGIK SLKGEAITDG PGILRIGAGI NGNDRFTGLM QDVRSYERKL TLEEIYELHA 1510 1520 1530 1540 1550 1560 MPAKSDLHPI SGYLEFRQGE TNKSFIISAR DDNDEEGEEL FILKLVSVYG GARISEENTT 1570 1580 1590 1600 1610 1620 ARLTIQKSDN ANGLFGFTGA CIPEIAEEGS TISCVVERTR GALDYVHVFY TISQIETDGI 1630 1640 1650 1660 1670 1680 NYLVDDFANA SGTITFLPWQ RSEVLNIYVL DDDIPELNEY FRVTLVSAIP GDGKLGSTPT 1690 1700 1710 1720 1730 1740 SGASIDPEKE TTDITIKASD HPYGLLQFST GLPPQPKDAM TLPASSVPHI TVEEEDGEIR 1750 1760 1770 1780 1790 1800 LLVIRAQGLL GRVTAEFRTV SLTAFSPEDY QNVAGTLEFQ PGERYKYIFI NITDNSIPEL 1810 1820 1830 1840 1850 1860 EKSFKVELLN LEGGVAELFR VDGSGSGDGD MEFFLPTIHK RASLGVASQI LVTIAASDHA 1870 1880 1890 1900 1910 1920 HGVFEFSPES LFVSGTEPED GYSTVTLNVI RHHGTLSPVT LHWNIDSDPD GDLAFTSGNI 1930 1940 1950 1960 1970 1980 TFEIGQTSAN ITVEILPDED PELDKAFSVS VLSVSSGSLG AHINATLTVL ASDDPYGIFI 1990 2000 2010 2020 2030 2040 FSEKNRPVKV EEATQNITLS IIRLKGLMGK VLVSYATLDD MEKPPYFPPN LARATQGRDY 2050 2060 2070 2080 2090 2100 IPASGFALFG ANQSEATIAI SILDDDEPER SESVFIELLN STLVAKVQSR SIPNSPRLGP 2110 2120 2130 2140 2150 2160 KVETIAQLII IANDDAFGTL QLSAPIVRVA ENHVGPIINV TRTGGAFADV SVKFKAVPIT 2170 2180 2190 2200 2210 2220 AIAGEDYSIA SSDVVLLEGE TSKAVPIYVI NDIYPELEES FLVQLMNETT GGARLGALTE 2230 2240 2250 2260 2270 2280 AVIIIEASDD PYGLFGFQIT KLIVEEPEFN SVKVNLPIIR NSGTLGNVTV QWVATINGQL 2290 2300 2310 2320 2330 2340 ATGDLRVVSG NVTFAPGETI QTLLLEVLAD DVPEIEEVIQ VQLTDASGGG TIGLDRIANI 2350 2360 2370 2380 2390 2400 IIPANDDPYG TVAFAQMVYR VQEPLERSSC ANITVRRSGG HFGRLLLFYS TSDIDVVALA 2410 2420 2430 2440 2450 2460 MEEGQDLLSY YESPIQGVPD PLWRTWMNVS AVGEPLYTCA TLCLKEQACS AFSFFSASEG 2470 2480 2490 2500 2510 2520 PQCFWMTSWI SPAVNNSDFW TYRKNMTRVA SLFSGQAVAG SDYEPVTRQW AIMQEGDEFA 2530 2540 2550 2560 2570 2580 NLTVSILPDD FPEMDESFLI SLLEVHLMNI SASLKNQPTI GQPNISTVVI ALNGDAFGVF 2590 2600 2610 2620 2630 2640 VIYNISPNTS EDGLFVEVQE QPQTLVELMI HRTGGSLGQV AVEWRVVGGT ATEGLDFIGA 2650 2660 2670 2680 2690 2700 GEILTFAEGE TKKTVILTIL DDSEPEDDES IIVSLVYTEG GSRILPSSDT VRVNILANDN 2710 2720 2730 2740 2750 2760 VAGIVSFQTA SRSVIGHEGE ILQFHVIRTF PGRGNVTVNW KIIGQNLELN FANFSGQLFF 2770 2780 2790 2800 2810 2820 PEGSLNTTLF VHLLDDNIPE EKEVYQVILY DVRTQGVPPA GIALLDAQGY AAVLTVEASD 2830 2840 2850 2860 2870 2880 EPHGVLNFAL SSRFVLLQEA NITIQLFINR EFGSLGAINV TYTTVPGMLS LKNQTVGNLA 2890 2900 2910 2920 2930 2940 EPEVDFVPII GFLILEEGET AAAINITILE DDVPELEEYF LVNLTYVGLT MAASTSFPPR 2950 2960 2970 2980 2990 3000 LDSEGLTAQV IIDANDGARG VIEWQQSRFE VNETHGSLTL VAQRSREPLG HVSLFVYAQN 3010 3020 3030 3040 3050 3060 LEAQVGLDYI FTPMILHFAD GERYKNVNIM ILDDDIPEGD EKFQLILTNP SPGLELGKNT 3070 3080 3090 3100 3110 3120 IALIIVLAND DGPGVLSFNN SEHFFLREPT ALYVQESVAV LYIVREPAQG LFGTVTVQFI 3130 3140 3150 3160 3170 3180 VTEVNSSNES KDLTPSKGYI VLEEGVRFKA LQISAILDTE PEMDEYFVCT LFNPTGGARL 3190 3200 3210 3220 3230 3240 GVHVQTLITV LQNQAPLGLF SISAVENRAT SIDIEEANRT VYLNVSRTNG IDLAVSVQWE 3250 3260 3270 3280 3290 3300 TVSETAFGMR GMDVVFSVFQ SFLDESASGW CFFTLENLIY GIMLRKSSVT VYRWQGIFIP 3310 3320 3330 3340 3350 3360 VEDLNIENPK TCEAFNIGFS PYFVITHEER NEEKPSLNSV FTFTSGFKLF LVQTIIILES 3370 3380 3390 3400 3410 3420 SQVRYFTSDS QDYLIIASQR DDSELTQVFR WNGGSFVLHQ KLPVRGVLTV ALFNKGGSVF 3430 3440 3450 3460 3470 3480 LAISQANARL NSLLFRWSGS GFINFQEVPV SGTTEVEALS SANDIYLIFA ENVFLGDQNS 3490 3500 3510 3520 3530 3540 IDIFIWEMGQ SSFRYFQSVD FAAVNRIHSF TPASGIAHIL LIGQDMSALY CWNSERNQFS 3550 3560 3570 3580 3590 3600 FVLEVPSAYD VASVTVKSLN SSKNLIALVG AHSHIYELAY ISSHSDFIPS SGELIFEPGE 3610 3620 3630 3640 3650 3660 REATIAVNIL DDTVPEKEES FKVQLKNPKG GAEIGINDSV TITILSNDDA YGIVAFAQNS 3670 3680 3690 3700 3710 3720 LYKQVEEMEQ DSLVTLNVER LKGTYGRITI AWEADGSISD IFPTSGVILF TEGQVLSTIT 3730 3740 3750 3760 3770 3780 LTILADNIPE LSEVVIVTLT RITTEGVEDS YKGATIDQDR SKSVITTLPN DSPFGLVGWR 3790 3800 3810 3820 3830 3840 AASVFIRVAE PKENTTTLQL QIARDKGLLG DIAIHLRAQP NFLLHVDNQA TENEDYVLQE 3850 3860 3870 3880 3890 3900 TIIIMKENIK EAHAEVSILP DDLPELEEGF IVTITEVNLV NSDFSTGQPS VRRPGMEIAE 3910 3920 3930 3940 3950 3960 IMIEENDDPR GIFMFHVTRG AGEVITAYEV PPPLNVLQVP VVRLAGSFGA VNVYWKASPD 3970 3980 3990 4000 4010 4020 SAGLEDFKPS HGILEFADKQ VTAMIEITII DDAEFELTET FNISLISVAG GGRLGDDVVV 4030 4040 4050 4060 4070 4080 TVVIPQNDSP FGVFGFEEKT VMIDESLSSD DPDSYVTLTV VRSPGGKGTV RLEWTIDEKA 4090 4100 4110 4120 4130 4140 KHNLSPLNGT LHFDETESQK TIVLHTLQDT VLEEDRRFTI QLISIDEVEI SPVKGSASII 4150 4160 4170 4180 4190 4200 IRGDKRASGE VGIAPSSRHI LIGEPSAKYN GTAIISLVRG PGILGEVTVF WRIFPPSVGE 4210 4220 4230 4240 4250 4260 FAETSGKLTM RDEQSAVIVV IQALNDDIPE EKSFYEFQLT AVSEGGVLSE SSSTANITVV 4270 4280 4290 4300 4310 4320 ASDSPYGRFA FSHEQLRVSE AQRVNITIIR SSGDFGHVRL WYKTMSGTAE AGLDFVPAAG 4330 4340 4350 4360 4370 4380 ELLFEAGEMR KSLHVEILDD DYPEGPEEFS LTITKVELQG RGYDFTIQEN GLQIDQPPEI 4390 4400 4410 4420 4430 4440 GNISIVRIII MKNDNAEGII EFDPKYTAFE VEEDVGLIMI PVVRLHGTYG YVTADFISQS 4450 4460 4470 4480 4490 4500 SSASPGGVDY ILHGSTVTFQ HGQNLSFINI SIIDDNESEF EEPIEILLTG ATGGAVLGRH 4510 4520 4530 4540 4550 4560 LVSRIIIAKS DSPFGVIRFL NQSKISIANP NSTMILSLVL ERTGGLLGEI QVNWETVGPN 4570 4580 4590 4600 4610 4620 SQEALLPQNR DIADPVSGLF YFGEGEGGVR TIILTIYPHE EIEVEETFII KLHLVKGEAK 4630 4640 4650 4660 4670 4680 LDSRAKDVTL TIQEFGDPNG VVQFAPETLS KKTYSEPLAL EGPLLITFFV RRVKGTFGEI 4690 4700 4710 4720 4730 4740 MVYWELSSEF DITEDFLSTS GFFTIADGES EASFDVHLLP DEVPEIEEDY VIQLVSVEGG 4750 4760 4770 4780 4790 4800 AELDLEKSIT WFSVYANDDP HGVFALYSDR QSILIGQNLI RSIQINITRL AGTFGDVAVG 4810 4820 4830 4840 4850 4860 LRISSDHKEQ PIVTENAERQ LVVKDGATYK VDVVPIKNQV FLSLGSNFTL QLVTVMLVGG 4870 4880 4890 4900 4910 4920 RFYGMPTILQ EAKSAVLPVS EKAANSQVGF ESTAFQLMNI TAGTSHVMIS RRGTYGALSV 4930 4940 4950 4960 4970 4980 AWTTGYAPGL EIPEFIVVGN MTPTLGSLSF SHGEQRKGVF LWTFPSPGWP EAFVLHLSGV 4990 5000 5010 5020 5030 5040 QSSAPGGAQL RSGFIVAEIE PMGVFQFSTS SRNIIVSEDT QMIRLHVQRL FGFHSDLIKV 5050 5060 5070 5080 5090 5100 SYQTTAGSAK PLEDFEPVQN GELFFQKFQT EVDFEITIIN DQLSEIEEFF YINLTSVEIR 5110 5120 5130 5140 5150 5160 GLQKFDVNWS PRLNLDFSVA VITILDNDDL AGMDISFPET TVAVAVDTTL IPVETESTTY 5170 5180 5190 5200 5210 5220 LSTSKTTTIL QPTNVVAIVT EATGVSAIPE KLVTLHGTPA VSEKPDVATV TANVSIHGTF 5230 5240 5250 5260 5270 5280 SLGPSIVYIE EEMKNGTFNT AEVLIRRTGG FTGNVSITVK TFGERCAQME PNALPFRGIY 5290 5300 5310 5320 5330 5340 GISNLTWAVE EEDFEEQTLT LIFLDGERER KVSVQILDDD EPEGQEFFYV FLTNPQGGAQ 5350 5360 5370 5380 5390 5400 IVEEKDDTGF AAFAMVIITG SDLHNGIIGF SEESQSGLEL REGAVMRRLH LIVTRQPNRA 5410 5420 5430 5440 5450 5460 FEDVKVFWRV TLNKTVVVLQ KDGVNLVEEL QSVSGTTTCT MGQTKCFISI ELKPEKVPQV 5470 5480 5490 5500 5510 5520 EVYFFVELYE ATAGAAINNS ARFAQIKILE SDESQSLVYF SVGSRLAVAH KKATLISLQV 5530 5540 5550 5560 5570 5580 ARDSGTGLMM SVNFSTQELR SAETIGRTII SPAISGKDFV ITEGTLVFEP GQRSTVLDVI 5590 5600 5610 5620 5630 5640 LTPETGSLNS FPKRFQIVLF DPKGGARIDK VYGTANITLV SDADSQAIWG LADQLHQPVN 5650 5660 5670 5680 5690 5700 DDILNRVLHT ISMKVATENT DEQLSAMMHL IEKITTEGKI QAFSVASRTL FYEILCSLIN 5710 5720 5730 5740 5750 5760 PKRKDTRGFS HFAEVTENFA FSLLTNVTCG SPGEKSKTIL DSCPYLSILA LHWYPQQING 5770 5780 5790 5800 5810 5820 HKFEGKEGDY IRIPERLLDV QDAEIMAGKS TCKLVQFTEY SSQQWFISGN NLPTLKNKVL 5830 5840 5850 5860 5870 5880 SLSVKGQSSQ LLTNDNEVLY RIYAAEPRII PQTSLCLLWN QAAASWLSDS QFCKVVEETA 5890 5900 5910 5920 5930 5940 DYVECACSHM SVYAVYARTD NLSSYNEAFF TSGFICISGL CLAVLSHIFC ARYSMFAAKL 5950 5960 5970 5980 5990 6000 LTHMMAASLG TQILFLASAY ASPQLAEESC SAMAAVTHYL YLCQFSWMLI QSVNFWYVLV 6010 6020 6030 6040 6050 6060 MNDEHTERRY LLFFLLSWGL PAFVVILLIV ILKGIYHQSM SQIYGLIHGD LCFIPNVYAA 6070 6080 6090 6100 6110 6120 LFTAALVPLT CLVVVFVVFI HAYQVKPQWK AYDDVFRGRT NAAEIPLILY LFALISVTWL 6130 6140 6150 6160 6170 6180 WGGLHMAYRH FWMLVLFVIF NSLQGLYVFM VYFILHNQMC CPMKASYTVE MNGHPGPSTA 6190 6200 6210 6220 6230 6240 FFTPGSGMPP AGGEISKSTQ NLIGAMEEVP PDWERASFQQ GSQASPDLKP SPQNGATFPS 6250 6260 6270 6280 6290 6300 SGGYGQGSLI ADEESQEFDD LIFALKTGAG LSVSDNESGQ GSQEGGTLTD SQIVELRRIP IADTHL
	Isoform 2 (VLGR1a) [UniParc]. Checksum: FB25C8F0D003EB47	FASTA	1,967	217,183
	10 20 30 40 50 60 MQLCIFCCCC ILFYFDLYDF GRGYDFTIQE NGLQIDQPPE IGNISIVRII IMKNDNAEGI 70 80 90 100 110 120 IEFDPKYTAF EVEEDVGLIM IPVVRLHGTY GYVTADFISQ SSSASPGGVD YILHGSTVTF 130 140 150 160 170 180 QHGQNLSFIN ISIIDDNESE FEEPIEILLT GATGGAVLGR HLVSRIIIAK SDSPFGVIRF 190 200 210 220 230 240 LNQSKISIAN PNSTMILSLV LERTGGLLGE IQVNWETVGP NSQEALLPQN RDIADPVSGL 250 260 270 280 290 300 FYFGEGEGGV RTIILTIYPH EEIEVEETFI IKLHLVKGEA KLDSRAKDVT LTIQEFGDPN 310 320 330 340 350 360 GVVQFAPETL SKKTYSEPLA LEGPLLITFF VRRVKGTFGE IMVYWELSSE FDITEDFLST 370 380 390 400 410 420 SGFFTIADGE SEASFDVHLL PDEVPEIEED YVIQLVSVEG GAELDLEKSI TWFSVYANDD 430 440 450 460 470 480 PHGVFALYSD RQSILIGQNL IRSIQINITR LAGTFGDVAV GLRISSDHKE QPIVTENAER 490 500 510 520 530 540 QLVVKDGATY KVDVVPIKNQ VFLSLGSNFT LQLVTVMLVG GRFYGMPTIL QEAKSAVLPV 550 560 570 580 590 600 SEKAANSQVG FESTAFQLMN ITAGTSHVMI SRRGTYGALS VAWTTGYAPG LEIPEFIVVG 610 620 630 640 650 660 NMTPTLGSLS FSHGEQRKGV FLWTFPSPGW PEAFVLHLSG VQSSAPGGAQ LRSGFIVAEI 670 680 690 700 710 720 EPMGVFQFST SSRNIIVSED TQMIRLHVQR LFGFHSDLIK VSYQTTAGSA KPLEDFEPVQ 730 740 750 760 770 780 NGELFFQKFQ TEVDFEITII NDQLSEIEEF FYINLTSVEI RGLQKFDVNW SPRLNLDFSV 790 800 810 820 830 840 AVITILDNDD LAGMDISFPE TTVAVAVDTT LIPVETESTT YLSTSKTTTI LQPTNVVAIV 850 860 870 880 890 900 TEATGVSAIP EKLVTLHGTP AVSEKPDVAT VTANVSIHGT FSLGPSIVYI EEEMKNGTFN 910 920 930 940 950 960 TAEVLIRRTG GFTGNVSITV KTFGERCAQM EPNALPFRGI YGISNLTWAV EEEDFEEQTL 970 980 990 1000 1010 1020 TLIFLDGERE RKVSVQILDD DEPEGQEFFY VFLTNPQGGA QIVEEKDDTG FAAFAMVIIT 1030 1040 1050 1060 1070 1080 GSDLHNGIIG FSEESQSGLE LREGAVMRRL HLIVTRQPNR AFEDVKVFWR VTLNKTVVVL 1090 1100 1110 1120 1130 1140 QKDGVNLVEE LQSVSGTTTC TMGQTKCFIS IELKPEKVPQ VEVYFFVELY EATAGAAINN 1150 1160 1170 1180 1190 1200 SARFAQIKIL ESDESQSLVY FSVGSRLAVA HKKATLISLQ VARDSGTGLM MSVNFSTQEL 1210 1220 1230 1240 1250 1260 RSAETIGRTI ISPAISGKDF VITEGTLVFE PGQRSTVLDV ILTPETGSLN SFPKRFQIVL 1270 1280 1290 1300 1310 1320 FDPKGGARID KVYGTANITL VSDADSQAIW GLADQLHQPV NDDILNRVLH TISMKVATEN 1330 1340 1350 1360 1370 1380 TDEQLSAMMH LIEKITTEGK IQAFSVASRT LFYEILCSLI NPKRKDTRGF SHFAEVTENF 1390 1400 1410 1420 1430 1440 AFSLLTNVTC GSPGEKSKTI LDSCPYLSIL ALHWYPQQIN GHKFEGKEGD YIRIPERLLD 1450 1460 1470 1480 1490 1500 VQDAEIMAGK STCKLVQFTE YSSQQWFISG NNLPTLKNKV LSLSVKGQSS QLLTNDNEVL 1510 1520 1530 1540 1550 1560 YRIYAAEPRI IPQTSLCLLW NQAAASWLSD SQFCKVVEET ADYVECACSH MSVYAVYART 1570 1580 1590 1600 1610 1620 DNLSSYNEAF FTSGFICISG LCLAVLSHIF CARYSMFAAK LLTHMMAASL GTQILFLASA 1630 1640 1650 1660 1670 1680 YASPQLAEES CSAMAAVTHY LYLCQFSWML IQSVNFWYVL VMNDEHTERR YLLFFLLSWG 1690 1700 1710 1720 1730 1740 LPAFVVILLI VILKGIYHQS MSQIYGLIHG DLCFIPNVYA ALFTAALVPL TCLVVVFVVF 1750 1760 1770 1780 1790 1800 IHAYQVKPQW KAYDDVFRGR TNAAEIPLIL YLFALISVTW LWGGLHMAYR HFWMLVLFVI 1810 1820 1830 1840 1850 1860 FNSLQGLYVF MVYFILHNQM CCPMKASYTV EMNGHPGPST AFFTPGSGMP PAGGEISKST 1870 1880 1890 1900 1910 1920 QNLIGAMEEV PPDWERASFQ QGSQASPDLK PSPQNGATFP SSGGYGQGSL IADEESQEFD 1930 1940 1950 1960 DLIFALKTGA GLSVSDNESG QGSQEGGTLT DSQIVELRRI PIADTHL
	Isoform 3 (VLGR1c) [UniParc]. Checksum: 0D3B4F197CF169D8	FASTA	2,306	252,843
	10 20 30 40 50 60 MSVFLGPGMP SASLLVNLLS ALLILFVFGE TEIRFTGQTE FVVNETSTTV IRLIIERIGE 70 80 90 100 110 120 PANVTAIVSL YGEDAGDFFD TYAAAFIPAG ETNRTVYIAV CDDDLPEPDE TFIFHLTLQK 130 140 150 160 170 180 PSANVKLGWP RTVTVTILSN DNAFGIISFN MLPSIAVSEP KGRNESMPLT LIREKGTYGM 190 200 210 220 230 240 VMVTFEVEGG PNPPDEDLSP VKGNITFPPG RATVIYNLTV LDDEVPENDE IFLIQLKSVE 250 260 270 280 290 300 GGAEINTSRN SIEIIIKKND SPVRFLQSIY LVPEEDHILI IPVVRGKDNN GNLIGSDEYE 310 320 330 340 350 360 VSISYAVTTG NSTAHAQQNL DFIDLQPNTT VVFPPFIHES HLKFQIVDDT IPEIAESFHI 370 380 390 400 410 420 MLLKDTLQGD AVLISPSVVQ VTIKPNDKPY GVLSFNSVLF ERTVIIDEDR ISRYEEITVV 430 440 450 460 470 480 RNGGTHGNVS ANWVLTRNST DPSPVTADIR PSSGVLHFAQ GQMLATIPLT VVDDDLPEEA 490 500 510 520 530 540 EAYLLQILPH TIRGGAEVSE PAELLFYIQD SDDVYGLITF FPMENQKIES SPGERYLSLS 550 560 570 580 590 600 FTRLGGTKGD VRLLYSVLYI PAGAVDPLQA KEGILNISRR NDLIFPEQKT QVTTKLPIRN 610 620 630 640 650 660 DAFLQNGAHF LVQLETVELL NIIPLIPPIS PRFGEICNIS LLVTPAIANG EIGFLSNLPI 670 680 690 700 710 720 ILHEPEDFAA EVVYIPLHRD GTDGQATVYW SLKPSGFNSK AVTPDDIGPF NGSVLFLSGQ 730 740 750 760 770 780 SDTTINITIK GDDIPEMNET VTLSLDRVNV ENQVLKSGYT SRDLIILEND DPGGVFEFSP 790 800 810 820 830 840 ASRGPYVIKE GESVELHIIR SRGSLVKQFL HYRVEPRDSN EFYGNTGVLE FKPGEREIVI 850 860 870 880 890 900 TLLARLDGIP ELDEHYWVVL SSHGERESKL GSATIVNITI LKNDDPHGII EFVSDGLIVM 910 920 930 940 950 960 INESKGDAIY SAVYDVVRNR GNFGDVSVSW VVSPDFTQDV FPVQGTVVFG DQEFSKNITI 970 980 990 1000 1010 1020 YSLPDEIPEE MEEFTVILLN GTGGAKVGNR TTATLRIRRN DDPIYFAEPR VVRVQEGETA 1030 1040 1050 1060 1070 1080 NFTVLRNGSV DVTCMVQYAT KDGKATARER DFIPVEKGET LIFEVGSRQQ SISIFVNEDG 1090 1100 1110 1120 1130 1140 IPETDEPFYI ILLNSTGDTV VYQYGVATVI IEANDDPNGI FSLEPIDKAV EEGKTNAFWI 1150 1160 1170 1180 1190 1200 LRHRGYFGSV SVSWQLFQND SALQPGQEFY ETSGTVNFMD GEEAKPIILH AFPDKIPEFN 1210 1220 1230 1240 1250 1260 EFYFLKLVNI SGGSPGPGGQ LAETNLQVTV MVPFNDDPFG VFILDPECLE REVAEDVLSE 1270 1280 1290 1300 1310 1320 DDMSYITNFT ILRQQGVFGD VQLGWEILSS EFPAGLPPMI DFLLVGIFPT TVHLQQHMRR 1330 1340 1350 1360 1370 1380 HHSGTDALYF TGLEGAFGTV NPKYHPSRNN TIANFTFSAW VMPNANTNGF IIAKDDGNGS 1390 1400 1410 1420 1430 1440 IYYGVKIQTN ESHVTLSLHY KTLGSNATYI AKTTVMKYLE ESVWLHLLII LEDGIIEFYL 1450 1460 1470 1480 1490 1500 DGNAMPRGIK SLKGEAITDG PGILRIGAGI NGNDRFTGLM QDVRSYERKL TLEEIYELHA 1510 1520 1530 1540 1550 1560 MPAKSDLHPI SGYLEFRQGE TNKSFIISAR DDNDEEGEEL FILKLVSVYG GARISEENTT 1570 1580 1590 1600 1610 1620 ARLTIQKSDN ANGLFGFTGA CIPEIAEEGS TISCVVERTR GALDYVHVFY TISQIETDGI 1630 1640 1650 1660 1670 1680 NYLVDDFANA SGTITFLPWQ RSEVLNIYVL DDDIPELNEY FRVTLVSAIP GDGKLGSTPT 1690 1700 1710 1720 1730 1740 SGASIDPEKE TTDITIKASD HPYGLLQFST GLPPQPKDAM TLPASSVPHI TVEEEDGEIR 1750 1760 1770 1780 1790 1800 LLVIRAQGLL GRVTAEFRTV SLTAFSPEDY QNVAGTLEFQ PGERYKYIFI NITDNSIPEL 1810 1820 1830 1840 1850 1860 EKSFKVELLN LEGGVAELFR VDGSGSGDGD MEFFLPTIHK RASLGVASQI LVTIAASDHA 1870 1880 1890 1900 1910 1920 HGVFEFSPES LFVSGTEPED GYSTVTLNVI RHHGTLSPVT LHWNIDSDPD GDLAFTSGNI 1930 1940 1950 1960 1970 1980 TFEIGQTSAN ITVEILPDED PELDKAFSVS VLSVSSGSLG AHINATLTVL ASDDPYGIFI 1990 2000 2010 2020 2030 2040 FSEKNRPVKV EEATQNITLS IIRLKGLMGK VLVSYATLDD MEKPPYFPPN LARATQGRDY 2050 2060 2070 2080 2090 2100 IPASGFALFG ANQSEATIAI SILDDDEPER SESVFIELLN STLVAKVQSR SIPNSPRLGP 2110 2120 2130 2140 2150 2160 KVETIAQLII IANDDAFGTL QLSAPIVRVA ENHVGPIINV TRTGGAFADV SVKFKAVPIT 2170 2180 2190 2200 2210 2220 AIAGEDYSIA SSDVVLLEGE TSKAVPIYVI NDIYPELEES FLVQLMNETT GGARLGALTE 2230 2240 2250 2260 2270 2280 AVIIIEASDD PYGLFGFQIT KLIVEEPEFN SVKVNLPIIR NSGTLGNVTV QWVATINGQL 2290 2300 ATGDLRVVSG NVTFARVVSG YPSATN
	Isoform 4 [UniParc]. Checksum: D213A1B3948A9453	FASTA	1,466	162,038
	10 20 30 40 50 60 MSVFLGPGMP SASLLVNLLS ALLILFVFGE TEIRFTGQTE FVVNETSTTV IRLIIERIGE 70 80 90 100 110 120 PANVTAIVSL YGEDAGDFFD TYAAAFIPAG ETNRTVYIAV CDDDLPEPDE TFIFHLTLQK 130 140 150 160 170 180 PSANVKLGWP RTVTVTILSN DNAFGIISFN MLPSIAVSEP KGRNESMPLT LIREKGTYGM 190 200 210 220 230 240 VMVTFEVEGG PNPPDEDLSP VKGNITFPPG RATVIYNLTV LDDEVPENDE IFLIQLKSVE 250 260 270 280 290 300 GGAEINTSRN SIEIIIKKND SPVRFLQSIY LVPEEDHILI IPVVRGKDNN GNLIGSDEYE 310 320 330 340 350 360 VSISYAVTTG NSTAHAQQNL DFIDLQPNTT VVFPPFIHES HLKFQIVDDT IPEIAESFHI 370 380 390 400 410 420 MLLKDTLQGD AVLISPSVVQ VTIKPNDKPY GVLSFNSVLF ERTVIIDEDR ISRYEEITVV 430 440 450 460 470 480 RNGGTHGNVS ANWVLTRNST DPSPVTADIR PSSGVLHFAQ GQMLATIPLT VVDDDLPEEA 490 500 510 520 530 540 EAYLLQILPH TIRGGAEVSE PAELLFYIQD SDDVYGLITF FPMENQKIES SPGERYLSLS 550 560 570 580 590 600 FTRLGGTKGD VRLLYSVLYI PAGAVDPLQA KEGILNISRR NDLIFPEQKT QVTTKLPIRN 610 620 630 640 650 660 DAFLQNGAHF LVQLETVELL NIIPLIPPIS PRFGEICNIS LLVTPAIANG EIGFLSNLPI 670 680 690 700 710 720 ILHEPEDFAA EVVYIPLHRD GTDGQATVYW SLKPSGFNSK AVTPDDIGPF NGSVLFLSGQ 730 740 750 760 770 780 SDTTINITIK GDDIPEMNET VTLSLDRVNV ENQVLKSGYT SRDLIILEND DPGGVFEFSP 790 800 810 820 830 840 ASRGPYVIKE GESVELHIIR SRGSLVKQFL HYRVEPRDSN EFYGNTGVLE FKPGEREIVI 850 860 870 880 890 900 TLLARLDGIP ELDEHYWVVL SSHGERESKL GSATIVNITI LKNDDPHGII EFVSDGLIVM 910 920 930 940 950 960 INESKGDAIY SAVYDVVRNR GNFGDVSVSW VVSPDFTQDV FPVQGTVVFG DQEFSKNITI 970 980 990 1000 1010 1020 YSLPDEIPEE MEEFTVILLN GTGGAKVGNR TTATLRIRRN DDPIYFAEPR VVRVQEGETA 1030 1040 1050 1060 1070 1080 NFTVLRNGSV DVTCMVQYAT KDGKATARER DFIPVEKGET LIFEVGSRQQ SISIFVNEDG 1090 1100 1110 1120 1130 1140 IPETDEPFYI ILLNSTGDTV VYQYGVATVI IEANDDPNGI FSLEPIDKAV EEGKTNAFWI 1150 1160 1170 1180 1190 1200 LRHRGYFGSV SVSWQLFQND SALQPGQEFY ETSGTVNFMD GEEAKPIILH AFPDKIPEFN 1210 1220 1230 1240 1250 1260 EFYFLKLVNI SGGSPGPGGQ LAETNLQVTV MVPFNDDPFG VFILDPECLE REVAEDVLSE 1270 1280 1290 1300 1310 1320 DDMSYITNFT ILRQQGVFGD VQLGWEILSS EFPAGLPPMI DFLLVGIFPT TVHLQQHMRR 1330 1340 1350 1360 1370 1380 HHSGTDALYF TGLEGAFGTV NPKYHPSRNN TIANFTFSAW VMPNANTNGF IIAKDDGNGS 1390 1400 1410 1420 1430 1440 IYYGVKIQTN ESHVTLSLHY KTLGSNATYI AKTTVMKYLE ESVWLHLLII LEDGIIEFYL 1450 1460 DGNAMPRGIK SLKGEAITDG EGHHHN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain." Nikkila H., McMillan D.R., Nunez B.S., Pascoe L., Curnow K.M., White P.C. Mol. Endocrinol. 14:1351-1364(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLY-5344, TISSUE SPECIFICITY.
[2]	"Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system." McMillan D.R., Kayes-Wandover K.M., Richardson J.A., White P.C. J. Biol. Chem. 277:785-792(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLY-5344, DEVELOPMENTAL STAGE.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 413-6306 (ISOFORM 4), VARIANT PHE-1093. Tissue: Brain.
[5]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2436-4042 (ISOFORM 1), VARIANTS SER-2584 AND LYS-3471. Tissue: Amygdala.
[6]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5107-6306 (ISOFORMS 1/2), VARIANT GLY-5344. Tissue: Brain.
[7]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[8]	"The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1." van Wijk E., van der Zwaag B., Peters T., Zimmermann U., Te Brinke H., Kersten F.F.J., Maerker T., Aller E., Hoefsloot L.H., Cremers C.W.R.J., Cremers F.P.M., Wolfrum U., Knipper M., Roepman R., Kremer H. Hum. Mol. Genet. 15:751-765(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH WHRN.
[9]	"A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures." Nakayama J., Fu Y.H., Clark A.M., Nakahara S., Hamano K., Iwasaki N., Matsui A., Arinami T., Ptacek L.J. Ann. Neurol. 52:654-657(2002) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE INVOLVEMENT IN FAMILIAL FEBRILE CONVULSIONS 4.
[10]	"Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II." Weston M.D., Luijendijk M.W.J., Humphrey K.D., Moeller C., Kimberling W.J. Am. J. Hum. Genet. 74:357-366(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN USH2C, VARIANTS ARG-127; LYS-249; PHE-1093; MET-1927; ILE-1951; ASP-1985; LEU-1987; PHE-2004; CYS-2232; SER-2345; ALA-2379; SER-2584; LEU-2764; THR-2803; VAL-3217; ASP-3248; LYS-3471 AND GLY-5344.
[11]	"PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome." Ebermann I., Phillips J.B., Liebau M.C., Koenekoop R.K., Schermer B., Lopez I., Schafer E., Roux A.F., Dafinger C., Bernd A., Zrenner E., Claustres M., Blanco B., Nurnberg G., Nurnberg P., Ruland R., Westerfield M., Benzing T., Bolz H.J. J. Clin. Invest. 120:1812-1823(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PDZD7.
[12]	"Non-USH2A mutations in USH2 patients." Besnard T., Vache C., Baux D., Larrieu L., Abadie C., Blanchet C., Odent S., Blanchet P., Calvas P., Hamel C., Dollfus H., Lina-Granade G., Lespinasse J., David A., Isidor B., Morin G., Malcolm S., Tuffery-Giraud S., Claustres M., Roux A.F. Hum. Mutat. 33:504-510(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS USH2C TRP-4789 AND ARG-5978.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF055084 mRNA. Translation: AAD55586.1. AF435925 mRNA. Translation: AAL30811.1. Frameshift. AC027323 Genomic DNA. No translation available. AC034215 Genomic DNA. No translation available. AC074132 Genomic DNA. No translation available. AC093281 Genomic DNA. No translation available. AC093529 Genomic DNA. No translation available. AC094109 Genomic DNA. No translation available. AC099512 Genomic DNA. No translation available. AB075823 mRNA. Translation: BAB85529.1. AL136541 mRNA. Translation: CAB66476.2. Sequence problems. AB014586 mRNA. Translation: BAA31661.2.
IPI	IPI00165934. IPI00743628. IPI00749231. IPI00902954.
RefSeq	NP_115495.3. NM_032119.3.
UniGene	Hs.591777.
3D structure databases
ProteinModelPortal	Q8WXG9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000384582.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8WXG9.
Polymorphism databases
DMDM	74716281.
Proteomic databases
PaxDb	Q8WXG9.
PRIDE	Q8WXG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000405460; ENSP00000384582; ENSG00000164199. ENST00000425867; ENSP00000392618; ENSG00000164199.
GeneID	84059.
KEGG	hsa:84059.
UCSC	uc003kjt.3. human.
Organism-specific databases
CTD	84059.
GeneCards	GC05P089891.
H-InvDB	HIX0005029.
HGNC	HGNC:17416. GPR98.
MIM	602851. gene. 604352. phenotype. 605472. phenotype.
neXtProt	NX_Q8WXG9.
Orphanet	231178. Usher syndrome type 2.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000088618.
HOVERGEN	HBG081572.
InParanoid	Q8WXG9.
OMA	PANDNPY.
OrthoDB	EOG4Q58NG.
Gene expression databases
ArrayExpress	Q8WXG9.
Bgee	Q8WXG9.
CleanEx	HS_GPR98.
Genevestigator	Q8WXG9.
GermOnline	ENSG00000164199. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR003644. Calx_beta. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR009039. EAR. IPR005492. EPTP. IPR017981. GPCR_2-like. IPR000832. GPCR_2_secretin-like. IPR026919. GPR98. IPR000203. GPS_dom. [Graphical view]
PANTHER	PTHR11878:SF10. PTHR11878:SF10. 1 hit.
Pfam	PF00002. 7tm_2. 1 hit. PF03160. Calx-beta. 16 hits. PF03736. EPTP. 1 hit. PF01825. GPS. 1 hit. [Graphical view]
SMART	SM00237. Calx_beta. 19 hits. SM00303. GPS. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50912. EAR. 5 hits. PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. False negative. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GPR98. human.
GenomeRNAi	84059.
NextBio	73207.
SOURCE	Search...

Entry information

Entry name

GPR98_HUMAN

Accession

Primary (citable) accession number: Q8WXG9
Secondary accession number(s): O75171 , Q8TF58, Q9H0X5, Q9UL61

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.