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Q8WXG9 (GPR98_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor 98
Alternative name(s):
Monogenic audiogenic seizure susceptibility protein 1 homolog
Usher syndrome type-2C protein
Very large G-protein coupled receptor 1
Gene names
Name:GPR98
Synonyms:KIAA0686, KIAA1943, MASS1, VLGR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length6306 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor that may have an important role in the development of the central nervous system.

Subunit structure

Interacts with WHRN. Interacts with PDZD7. Ref.8 Ref.11

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed at low levels in adult tissues. Ref.1

Developmental stage

Isoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively. Ref.2

Involvement in disease

Usher syndrome 2C (USH2C) [MIM:605472]: USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.12

Febrile seizures, familial, 4 (FEB4) [MIM:604352]: Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
Note: The disease may be caused by mutations affecting the gene represented in this entry.

Miscellaneous

By far is the largest known cell surface protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 35 Calx-beta domains.

Contains 6 EAR repeats.

Contains 1 GPS domain.

Sequence caution

The sequence AAL30811.1 differs from that shown. Reason: Frameshift at positions 3524 and 3532.

The sequence CAB66476.2 differs from that shown. Reason: Erroneous translation. Wrong genetic code use for translating the sequence.

Ontologies

Keywords
   Biological processSensory transduction
Vision
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDeafness
Retinitis pigmentosa
Usher syndrome
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 15203201. Source: GDB

detection of mechanical stimulus involved in sensory perception of sound

Inferred from electronic annotation. Source: Ensembl

inner ear receptor stereocilium organization

Inferred from electronic annotation. Source: Ensembl

maintenance of organ identity

Inferred from mutant phenotype PubMed 15671307. Source: HGNC

nervous system development

Non-traceable author statement Ref.2. Source: UniProtKB

neurological system process

Inferred from mutant phenotype Ref.9. Source: HGNC

neuropeptide signaling pathway

Inferred from electronic annotation. Source: InterPro

photoreceptor cell maintenance

Inferred from mutant phenotype Ref.10. Source: HGNC

sensory perception of light stimulus

Inferred from mutant phenotype Ref.10PubMed 15671307. Source: HGNC

sensory perception of sound

Inferred from mutant phenotype Ref.10. Source: HGNC

single organismal cell-cell adhesion

Non-traceable author statement Ref.2. Source: UniProtKB

visual perception

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell surface

Inferred from direct assay Ref.1. Source: HGNC

cytoplasm

Inferred from direct assay Ref.8. Source: HGNC

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

integral component of membrane

Traceable author statement PubMed 15203201. Source: GDB

membrane

Non-traceable author statement Ref.2. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

receptor complex

Inferred from direct assay PubMed 23382219. Source: MGI

stereocilia ankle link complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionG-protein coupled receptor activity

Non-traceable author statement Ref.2. Source: UniProtKB

calcium ion binding

Inferred from direct assay Ref.1. Source: HGNC

protein binding

Inferred from physical interaction Ref.11. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WXG9-1)

Also known as: VLGR1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WXG9-2)

Also known as: VLGR1a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-4339: Missing.
     4340-4359: DDYPEGPEEFSLTITKVELQ → MQLCIFCCCCILFYFDLYDF
Isoform 3 (identifier: Q8WXG9-3)

Also known as: VLGR1c;

The sequence of this isoform differs from the canonical sequence as follows:
     2296-2306: PGETIQTLLLE → RVVSGYPSATN
     2307-6306: Missing.
Isoform 4 (identifier: Q8WXG9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1461-1466: PGILRI → EGHHHN
     1467-6306: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 63066277G-protein coupled receptor 98
PRO_0000232735

Regions

Topological domain30 – 59085879Extracellular Potential
Transmembrane5909 – 592921Helical; Potential
Topological domain5930 – 593910Cytoplasmic Potential
Transmembrane5940 – 596021Helical; Potential
Topological domain5961 – 597919Extracellular Potential
Transmembrane5980 – 600021Helical; Potential
Topological domain6001 – 601010Cytoplasmic Potential
Transmembrane6011 – 603121Helical; Potential
Topological domain6032 – 605928Extracellular Potential
Transmembrane6060 – 608021Helical; Potential
Topological domain6081 – 610424Cytoplasmic Potential
Transmembrane6105 – 612521Helical; Potential
Topological domain6126 – 61338Extracellular Potential
Transmembrane6134 – 615421Helical; Potential
Topological domain6155 – 6306152Cytoplasmic Potential
Domain77 – 11640Calx-beta 1
Domain195 – 23541Calx-beta 2
Domain321 – 36242Calx-beta 3
Domain447 – 48842Calx-beta 4
Domain706 – 74540Calx-beta 5
Domain821 – 86141Calx-beta 6
Domain938 – 97942Calx-beta 7
Domain1051 – 109242Calx-beta 8
Domain1167 – 120842Calx-beta 9
Domain1504 – 154441Calx-beta 10
Domain1626 – 166641Calx-beta 11
Domain1767 – 180842Calx-beta 12
Domain1911 – 194131Calx-beta 13
Domain2038 – 207841Calx-beta 14
Domain2165 – 220541Calx-beta 15
Domain2283 – 232341Calx-beta 16
Domain2501 – 254141Calx-beta 17
Domain2635 – 267541Calx-beta 18
Domain2749 – 278941Calx-beta 19
Domain2884 – 292441Calx-beta 20
Domain3007 – 304741Calx-beta 21
Domain3131 – 317141Calx-beta 22
Repeat3189 – 324153EAR 1
Repeat3296 – 334550EAR 2
Repeat3347 – 339347EAR 3
Repeat3394 – 343946EAR 4
Repeat3440 – 348849EAR 5
Repeat3491 – 353444EAR 6
Domain3584 – 362542Calx-beta 23
Domain3700 – 373940Calx-beta 24
Domain3834 – 387542Calx-beta 25
Domain3965 – 400541Calx-beta 26
Domain4082 – 412241Calx-beta 27
Domain4199 – 423941Calx-beta 28
Domain4313 – 435341Calx-beta 29
Domain4448 – 448841Calx-beta 30
Domain4570 – 461243Calx-beta 31
Domain4693 – 473442Calx-beta 32
Domain5053 – 509442Calx-beta 33
Domain5291 – 533343Calx-beta 34
Domain5427 – 546842Calx-beta 35
Domain5853 – 590250GPS

Natural variations

Alternative sequence1 – 43394339Missing in isoform 2.
VSP_017947
Alternative sequence1461 – 14666PGILRI → EGHHHN in isoform 4.
VSP_035313
Alternative sequence1467 – 63064840Missing in isoform 4.
VSP_035314
Alternative sequence2296 – 230611PGETIQTLLLE → RVVSGYPSATN in isoform 3.
VSP_017948
Alternative sequence2307 – 63064000Missing in isoform 3.
VSP_017949
Alternative sequence4340 – 435920DDYPE…KVELQ → MQLCIFCCCCILFYFDLYDF in isoform 2.
VSP_017950
Natural variant1271L → R. Ref.10
Corresponds to variant rs41311333 [ dbSNP | Ensembl ].
VAR_025995
Natural variant2491R → K. Ref.10
Corresponds to variant rs41303344 [ dbSNP | Ensembl ].
VAR_025996
Natural variant5511V → A.
Corresponds to variant rs6889939 [ dbSNP | Ensembl ].
VAR_046346
Natural variant10931L → F. Ref.4 Ref.10
Corresponds to variant rs2366777 [ dbSNP | Ensembl ].
VAR_025997
Natural variant11871I → V.
Corresponds to variant rs16868935 [ dbSNP | Ensembl ].
VAR_046347
Natural variant19161T → I.
Corresponds to variant rs35791889 [ dbSNP | Ensembl ].
VAR_046348
Natural variant19271T → M. Ref.10
Corresponds to variant rs17544552 [ dbSNP | Ensembl ].
VAR_025998
Natural variant19511V → I. Ref.10
Corresponds to variant rs4916684 [ dbSNP | Ensembl ].
VAR_025999
Natural variant19851N → D. Ref.10
Corresponds to variant rs41303352 [ dbSNP | Ensembl ].
VAR_026000
Natural variant19871P → L. Ref.10
Corresponds to variant rs4916685 [ dbSNP | Ensembl ].
VAR_026001
Natural variant20041L → F. Ref.10
Corresponds to variant rs16868972 [ dbSNP | Ensembl ].
VAR_026002
Natural variant20971R → C.
Corresponds to variant rs16868974 [ dbSNP | Ensembl ].
VAR_046349
Natural variant22321Y → C. Ref.10
Corresponds to variant rs10037067 [ dbSNP | Ensembl ].
VAR_026003
Natural variant23451N → S. Ref.10
Corresponds to variant rs2366926 [ dbSNP | Ensembl ].
VAR_026004
Natural variant23791G → A. Ref.10
VAR_026005
Natural variant25841N → S. Ref.5 Ref.10
Corresponds to variant rs1878878 [ dbSNP | Ensembl ].
VAR_026006
Natural variant27641S → L. Ref.10
Corresponds to variant rs16869016 [ dbSNP | Ensembl ].
VAR_026007
Natural variant28031A → T. Ref.10
Corresponds to variant rs111033530 [ dbSNP | Ensembl ].
VAR_026008
Natural variant30941V → I.
Corresponds to variant rs13157270 [ dbSNP | Ensembl ].
VAR_046350
Natural variant32171A → V. Ref.10
Corresponds to variant rs114137750 [ dbSNP | Ensembl ].
VAR_026009
Natural variant32481G → D. Ref.10
Corresponds to variant rs16869032 [ dbSNP | Ensembl ].
VAR_026010
Natural variant33471F → L.
Corresponds to variant rs10067636 [ dbSNP | Ensembl ].
VAR_046351
Natural variant34711E → K. Ref.5 Ref.10
Corresponds to variant rs2366928 [ dbSNP | Ensembl ].
VAR_026011
Natural variant38671E → A.
Corresponds to variant rs16869088 [ dbSNP | Ensembl ].
VAR_046352
Natural variant38681E → A.
Corresponds to variant rs16869088 [ dbSNP | Ensembl ].
VAR_055933
Natural variant47891R → W in USH2C. Ref.12
VAR_068032
Natural variant53441E → G. Ref.1 Ref.2 Ref.6 Ref.10
Corresponds to variant rs2438374 [ dbSNP | Ensembl ].
VAR_026012
Natural variant54371T → A.
VAR_026013
Natural variant59781H → R in USH2C. Ref.12
VAR_068033

Experimental info

Sequence conflict1071E → G in AAL30811. Ref.2
Sequence conflict2191T → A in AAL30811. Ref.2
Sequence conflict2571K → E in AAL30811. Ref.2
Sequence conflict435 – 4373LTR → VTP in AAL30811. Ref.2
Sequence conflict471 – 4722VV → GG in AAL30811. Ref.2
Sequence conflict5341E → G in AAL30811. Ref.2
Sequence conflict7471R → W in AAL30811. Ref.2
Sequence conflict10961T → P in AAL30811. Ref.2
Sequence conflict10991T → P in AAL30811. Ref.2
Sequence conflict12321V → A in AAL30811. Ref.2
Sequence conflict13201R → G in AAL30811. Ref.2
Sequence conflict1340 – 13423VNP → GNS in AAL30811. Ref.2
Sequence conflict13471S → F in AAL30811. Ref.2
Sequence conflict32301G → D in AAL30811. Ref.2
Sequence conflict35281A → T in AAL30811. Ref.2
Sequence conflict35521A → V in AAL30811. Ref.2
Sequence conflict42441E → G in AAL30811. Ref.2
Sequence conflict54271V → M in AAD55586. Ref.1
Sequence conflict54271V → M in AAL30811. Ref.2
Sequence conflict54271V → M in BAA31661. Ref.6
Sequence conflict58761V → I in AAD55586. Ref.1
Sequence conflict58761V → I in AAL30811. Ref.2
Sequence conflict58761V → I in BAA31661. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (VLGR1b) [UniParc].

Last modified April 5, 2011. Version 2.
Checksum: 30168F374ACEEF24

FASTA6,306693,069
        10         20         30         40         50         60 
MSVFLGPGMP SASLLVNLLS ALLILFVFGE TEIRFTGQTE FVVNETSTTV IRLIIERIGE 

        70         80         90        100        110        120 
PANVTAIVSL YGEDAGDFFD TYAAAFIPAG ETNRTVYIAV CDDDLPEPDE TFIFHLTLQK 

       130        140        150        160        170        180 
PSANVKLGWP RTVTVTILSN DNAFGIISFN MLPSIAVSEP KGRNESMPLT LIREKGTYGM 

       190        200        210        220        230        240 
VMVTFEVEGG PNPPDEDLSP VKGNITFPPG RATVIYNLTV LDDEVPENDE IFLIQLKSVE 

       250        260        270        280        290        300 
GGAEINTSRN SIEIIIKKND SPVRFLQSIY LVPEEDHILI IPVVRGKDNN GNLIGSDEYE 

       310        320        330        340        350        360 
VSISYAVTTG NSTAHAQQNL DFIDLQPNTT VVFPPFIHES HLKFQIVDDT IPEIAESFHI 

       370        380        390        400        410        420 
MLLKDTLQGD AVLISPSVVQ VTIKPNDKPY GVLSFNSVLF ERTVIIDEDR ISRYEEITVV 

       430        440        450        460        470        480 
RNGGTHGNVS ANWVLTRNST DPSPVTADIR PSSGVLHFAQ GQMLATIPLT VVDDDLPEEA 

       490        500        510        520        530        540 
EAYLLQILPH TIRGGAEVSE PAELLFYIQD SDDVYGLITF FPMENQKIES SPGERYLSLS 

       550        560        570        580        590        600 
FTRLGGTKGD VRLLYSVLYI PAGAVDPLQA KEGILNISRR NDLIFPEQKT QVTTKLPIRN 

       610        620        630        640        650        660 
DAFLQNGAHF LVQLETVELL NIIPLIPPIS PRFGEICNIS LLVTPAIANG EIGFLSNLPI 

       670        680        690        700        710        720 
ILHEPEDFAA EVVYIPLHRD GTDGQATVYW SLKPSGFNSK AVTPDDIGPF NGSVLFLSGQ 

       730        740        750        760        770        780 
SDTTINITIK GDDIPEMNET VTLSLDRVNV ENQVLKSGYT SRDLIILEND DPGGVFEFSP 

       790        800        810        820        830        840 
ASRGPYVIKE GESVELHIIR SRGSLVKQFL HYRVEPRDSN EFYGNTGVLE FKPGEREIVI 

       850        860        870        880        890        900 
TLLARLDGIP ELDEHYWVVL SSHGERESKL GSATIVNITI LKNDDPHGII EFVSDGLIVM 

       910        920        930        940        950        960 
INESKGDAIY SAVYDVVRNR GNFGDVSVSW VVSPDFTQDV FPVQGTVVFG DQEFSKNITI 

       970        980        990       1000       1010       1020 
YSLPDEIPEE MEEFTVILLN GTGGAKVGNR TTATLRIRRN DDPIYFAEPR VVRVQEGETA 

      1030       1040       1050       1060       1070       1080 
NFTVLRNGSV DVTCMVQYAT KDGKATARER DFIPVEKGET LIFEVGSRQQ SISIFVNEDG 

      1090       1100       1110       1120       1130       1140 
IPETDEPFYI ILLNSTGDTV VYQYGVATVI IEANDDPNGI FSLEPIDKAV EEGKTNAFWI 

      1150       1160       1170       1180       1190       1200 
LRHRGYFGSV SVSWQLFQND SALQPGQEFY ETSGTVNFMD GEEAKPIILH AFPDKIPEFN 

      1210       1220       1230       1240       1250       1260 
EFYFLKLVNI SGGSPGPGGQ LAETNLQVTV MVPFNDDPFG VFILDPECLE REVAEDVLSE 

      1270       1280       1290       1300       1310       1320 
DDMSYITNFT ILRQQGVFGD VQLGWEILSS EFPAGLPPMI DFLLVGIFPT TVHLQQHMRR 

      1330       1340       1350       1360       1370       1380 
HHSGTDALYF TGLEGAFGTV NPKYHPSRNN TIANFTFSAW VMPNANTNGF IIAKDDGNGS 

      1390       1400       1410       1420       1430       1440 
IYYGVKIQTN ESHVTLSLHY KTLGSNATYI AKTTVMKYLE ESVWLHLLII LEDGIIEFYL 

      1450       1460       1470       1480       1490       1500 
DGNAMPRGIK SLKGEAITDG PGILRIGAGI NGNDRFTGLM QDVRSYERKL TLEEIYELHA 

      1510       1520       1530       1540       1550       1560 
MPAKSDLHPI SGYLEFRQGE TNKSFIISAR DDNDEEGEEL FILKLVSVYG GARISEENTT 

      1570       1580       1590       1600       1610       1620 
ARLTIQKSDN ANGLFGFTGA CIPEIAEEGS TISCVVERTR GALDYVHVFY TISQIETDGI 

      1630       1640       1650       1660       1670       1680 
NYLVDDFANA SGTITFLPWQ RSEVLNIYVL DDDIPELNEY FRVTLVSAIP GDGKLGSTPT 

      1690       1700       1710       1720       1730       1740 
SGASIDPEKE TTDITIKASD HPYGLLQFST GLPPQPKDAM TLPASSVPHI TVEEEDGEIR 

      1750       1760       1770       1780       1790       1800 
LLVIRAQGLL GRVTAEFRTV SLTAFSPEDY QNVAGTLEFQ PGERYKYIFI NITDNSIPEL 

      1810       1820       1830       1840       1850       1860 
EKSFKVELLN LEGGVAELFR VDGSGSGDGD MEFFLPTIHK RASLGVASQI LVTIAASDHA 

      1870       1880       1890       1900       1910       1920 
HGVFEFSPES LFVSGTEPED GYSTVTLNVI RHHGTLSPVT LHWNIDSDPD GDLAFTSGNI 

      1930       1940       1950       1960       1970       1980 
TFEIGQTSAN ITVEILPDED PELDKAFSVS VLSVSSGSLG AHINATLTVL ASDDPYGIFI 

      1990       2000       2010       2020       2030       2040 
FSEKNRPVKV EEATQNITLS IIRLKGLMGK VLVSYATLDD MEKPPYFPPN LARATQGRDY 

      2050       2060       2070       2080       2090       2100 
IPASGFALFG ANQSEATIAI SILDDDEPER SESVFIELLN STLVAKVQSR SIPNSPRLGP 

      2110       2120       2130       2140       2150       2160 
KVETIAQLII IANDDAFGTL QLSAPIVRVA ENHVGPIINV TRTGGAFADV SVKFKAVPIT 

      2170       2180       2190       2200       2210       2220 
AIAGEDYSIA SSDVVLLEGE TSKAVPIYVI NDIYPELEES FLVQLMNETT GGARLGALTE 

      2230       2240       2250       2260       2270       2280 
AVIIIEASDD PYGLFGFQIT KLIVEEPEFN SVKVNLPIIR NSGTLGNVTV QWVATINGQL 

      2290       2300       2310       2320       2330       2340 
ATGDLRVVSG NVTFAPGETI QTLLLEVLAD DVPEIEEVIQ VQLTDASGGG TIGLDRIANI 

      2350       2360       2370       2380       2390       2400 
IIPANDDPYG TVAFAQMVYR VQEPLERSSC ANITVRRSGG HFGRLLLFYS TSDIDVVALA 

      2410       2420       2430       2440       2450       2460 
MEEGQDLLSY YESPIQGVPD PLWRTWMNVS AVGEPLYTCA TLCLKEQACS AFSFFSASEG 

      2470       2480       2490       2500       2510       2520 
PQCFWMTSWI SPAVNNSDFW TYRKNMTRVA SLFSGQAVAG SDYEPVTRQW AIMQEGDEFA 

      2530       2540       2550       2560       2570       2580 
NLTVSILPDD FPEMDESFLI SLLEVHLMNI SASLKNQPTI GQPNISTVVI ALNGDAFGVF 

      2590       2600       2610       2620       2630       2640 
VIYNISPNTS EDGLFVEVQE QPQTLVELMI HRTGGSLGQV AVEWRVVGGT ATEGLDFIGA 

      2650       2660       2670       2680       2690       2700 
GEILTFAEGE TKKTVILTIL DDSEPEDDES IIVSLVYTEG GSRILPSSDT VRVNILANDN 

      2710       2720       2730       2740       2750       2760 
VAGIVSFQTA SRSVIGHEGE ILQFHVIRTF PGRGNVTVNW KIIGQNLELN FANFSGQLFF 

      2770       2780       2790       2800       2810       2820 
PEGSLNTTLF VHLLDDNIPE EKEVYQVILY DVRTQGVPPA GIALLDAQGY AAVLTVEASD 

      2830       2840       2850       2860       2870       2880 
EPHGVLNFAL SSRFVLLQEA NITIQLFINR EFGSLGAINV TYTTVPGMLS LKNQTVGNLA 

      2890       2900       2910       2920       2930       2940 
EPEVDFVPII GFLILEEGET AAAINITILE DDVPELEEYF LVNLTYVGLT MAASTSFPPR 

      2950       2960       2970       2980       2990       3000 
LDSEGLTAQV IIDANDGARG VIEWQQSRFE VNETHGSLTL VAQRSREPLG HVSLFVYAQN 

      3010       3020       3030       3040       3050       3060 
LEAQVGLDYI FTPMILHFAD GERYKNVNIM ILDDDIPEGD EKFQLILTNP SPGLELGKNT 

      3070       3080       3090       3100       3110       3120 
IALIIVLAND DGPGVLSFNN SEHFFLREPT ALYVQESVAV LYIVREPAQG LFGTVTVQFI 

      3130       3140       3150       3160       3170       3180 
VTEVNSSNES KDLTPSKGYI VLEEGVRFKA LQISAILDTE PEMDEYFVCT LFNPTGGARL 

      3190       3200       3210       3220       3230       3240 
GVHVQTLITV LQNQAPLGLF SISAVENRAT SIDIEEANRT VYLNVSRTNG IDLAVSVQWE 

      3250       3260       3270       3280       3290       3300 
TVSETAFGMR GMDVVFSVFQ SFLDESASGW CFFTLENLIY GIMLRKSSVT VYRWQGIFIP 

      3310       3320       3330       3340       3350       3360 
VEDLNIENPK TCEAFNIGFS PYFVITHEER NEEKPSLNSV FTFTSGFKLF LVQTIIILES 

      3370       3380       3390       3400       3410       3420 
SQVRYFTSDS QDYLIIASQR DDSELTQVFR WNGGSFVLHQ KLPVRGVLTV ALFNKGGSVF 

      3430       3440       3450       3460       3470       3480 
LAISQANARL NSLLFRWSGS GFINFQEVPV SGTTEVEALS SANDIYLIFA ENVFLGDQNS 

      3490       3500       3510       3520       3530       3540 
IDIFIWEMGQ SSFRYFQSVD FAAVNRIHSF TPASGIAHIL LIGQDMSALY CWNSERNQFS 

      3550       3560       3570       3580       3590       3600 
FVLEVPSAYD VASVTVKSLN SSKNLIALVG AHSHIYELAY ISSHSDFIPS SGELIFEPGE 

      3610       3620       3630       3640       3650       3660 
REATIAVNIL DDTVPEKEES FKVQLKNPKG GAEIGINDSV TITILSNDDA YGIVAFAQNS 

      3670       3680       3690       3700       3710       3720 
LYKQVEEMEQ DSLVTLNVER LKGTYGRITI AWEADGSISD IFPTSGVILF TEGQVLSTIT 

      3730       3740       3750       3760       3770       3780 
LTILADNIPE LSEVVIVTLT RITTEGVEDS YKGATIDQDR SKSVITTLPN DSPFGLVGWR 

      3790       3800       3810       3820       3830       3840 
AASVFIRVAE PKENTTTLQL QIARDKGLLG DIAIHLRAQP NFLLHVDNQA TENEDYVLQE 

      3850       3860       3870       3880       3890       3900 
TIIIMKENIK EAHAEVSILP DDLPELEEGF IVTITEVNLV NSDFSTGQPS VRRPGMEIAE 

      3910       3920       3930       3940       3950       3960 
IMIEENDDPR GIFMFHVTRG AGEVITAYEV PPPLNVLQVP VVRLAGSFGA VNVYWKASPD 

      3970       3980       3990       4000       4010       4020 
SAGLEDFKPS HGILEFADKQ VTAMIEITII DDAEFELTET FNISLISVAG GGRLGDDVVV 

      4030       4040       4050       4060       4070       4080 
TVVIPQNDSP FGVFGFEEKT VMIDESLSSD DPDSYVTLTV VRSPGGKGTV RLEWTIDEKA 

      4090       4100       4110       4120       4130       4140 
KHNLSPLNGT LHFDETESQK TIVLHTLQDT VLEEDRRFTI QLISIDEVEI SPVKGSASII 

      4150       4160       4170       4180       4190       4200 
IRGDKRASGE VGIAPSSRHI LIGEPSAKYN GTAIISLVRG PGILGEVTVF WRIFPPSVGE 

      4210       4220       4230       4240       4250       4260 
FAETSGKLTM RDEQSAVIVV IQALNDDIPE EKSFYEFQLT AVSEGGVLSE SSSTANITVV 

      4270       4280       4290       4300       4310       4320 
ASDSPYGRFA FSHEQLRVSE AQRVNITIIR SSGDFGHVRL WYKTMSGTAE AGLDFVPAAG 

      4330       4340       4350       4360       4370       4380 
ELLFEAGEMR KSLHVEILDD DYPEGPEEFS LTITKVELQG RGYDFTIQEN GLQIDQPPEI 

      4390       4400       4410       4420       4430       4440 
GNISIVRIII MKNDNAEGII EFDPKYTAFE VEEDVGLIMI PVVRLHGTYG YVTADFISQS 

      4450       4460       4470       4480       4490       4500 
SSASPGGVDY ILHGSTVTFQ HGQNLSFINI SIIDDNESEF EEPIEILLTG ATGGAVLGRH 

      4510       4520       4530       4540       4550       4560 
LVSRIIIAKS DSPFGVIRFL NQSKISIANP NSTMILSLVL ERTGGLLGEI QVNWETVGPN 

      4570       4580       4590       4600       4610       4620 
SQEALLPQNR DIADPVSGLF YFGEGEGGVR TIILTIYPHE EIEVEETFII KLHLVKGEAK 

      4630       4640       4650       4660       4670       4680 
LDSRAKDVTL TIQEFGDPNG VVQFAPETLS KKTYSEPLAL EGPLLITFFV RRVKGTFGEI 

      4690       4700       4710       4720       4730       4740 
MVYWELSSEF DITEDFLSTS GFFTIADGES EASFDVHLLP DEVPEIEEDY VIQLVSVEGG 

      4750       4760       4770       4780       4790       4800 
AELDLEKSIT WFSVYANDDP HGVFALYSDR QSILIGQNLI RSIQINITRL AGTFGDVAVG 

      4810       4820       4830       4840       4850       4860 
LRISSDHKEQ PIVTENAERQ LVVKDGATYK VDVVPIKNQV FLSLGSNFTL QLVTVMLVGG 

      4870       4880       4890       4900       4910       4920 
RFYGMPTILQ EAKSAVLPVS EKAANSQVGF ESTAFQLMNI TAGTSHVMIS RRGTYGALSV 

      4930       4940       4950       4960       4970       4980 
AWTTGYAPGL EIPEFIVVGN MTPTLGSLSF SHGEQRKGVF LWTFPSPGWP EAFVLHLSGV 

      4990       5000       5010       5020       5030       5040 
QSSAPGGAQL RSGFIVAEIE PMGVFQFSTS SRNIIVSEDT QMIRLHVQRL FGFHSDLIKV 

      5050       5060       5070       5080       5090       5100 
SYQTTAGSAK PLEDFEPVQN GELFFQKFQT EVDFEITIIN DQLSEIEEFF YINLTSVEIR 

      5110       5120       5130       5140       5150       5160 
GLQKFDVNWS PRLNLDFSVA VITILDNDDL AGMDISFPET TVAVAVDTTL IPVETESTTY 

      5170       5180       5190       5200       5210       5220 
LSTSKTTTIL QPTNVVAIVT EATGVSAIPE KLVTLHGTPA VSEKPDVATV TANVSIHGTF 

      5230       5240       5250       5260       5270       5280 
SLGPSIVYIE EEMKNGTFNT AEVLIRRTGG FTGNVSITVK TFGERCAQME PNALPFRGIY 

      5290       5300       5310       5320       5330       5340 
GISNLTWAVE EEDFEEQTLT LIFLDGERER KVSVQILDDD EPEGQEFFYV FLTNPQGGAQ 

      5350       5360       5370       5380       5390       5400 
IVEEKDDTGF AAFAMVIITG SDLHNGIIGF SEESQSGLEL REGAVMRRLH LIVTRQPNRA 

      5410       5420       5430       5440       5450       5460 
FEDVKVFWRV TLNKTVVVLQ KDGVNLVEEL QSVSGTTTCT MGQTKCFISI ELKPEKVPQV 

      5470       5480       5490       5500       5510       5520 
EVYFFVELYE ATAGAAINNS ARFAQIKILE SDESQSLVYF SVGSRLAVAH KKATLISLQV 

      5530       5540       5550       5560       5570       5580 
ARDSGTGLMM SVNFSTQELR SAETIGRTII SPAISGKDFV ITEGTLVFEP GQRSTVLDVI 

      5590       5600       5610       5620       5630       5640 
LTPETGSLNS FPKRFQIVLF DPKGGARIDK VYGTANITLV SDADSQAIWG LADQLHQPVN 

      5650       5660       5670       5680       5690       5700 
DDILNRVLHT ISMKVATENT DEQLSAMMHL IEKITTEGKI QAFSVASRTL FYEILCSLIN 

      5710       5720       5730       5740       5750       5760 
PKRKDTRGFS HFAEVTENFA FSLLTNVTCG SPGEKSKTIL DSCPYLSILA LHWYPQQING 

      5770       5780       5790       5800       5810       5820 
HKFEGKEGDY IRIPERLLDV QDAEIMAGKS TCKLVQFTEY SSQQWFISGN NLPTLKNKVL 

      5830       5840       5850       5860       5870       5880 
SLSVKGQSSQ LLTNDNEVLY RIYAAEPRII PQTSLCLLWN QAAASWLSDS QFCKVVEETA 

      5890       5900       5910       5920       5930       5940 
DYVECACSHM SVYAVYARTD NLSSYNEAFF TSGFICISGL CLAVLSHIFC ARYSMFAAKL 

      5950       5960       5970       5980       5990       6000 
LTHMMAASLG TQILFLASAY ASPQLAEESC SAMAAVTHYL YLCQFSWMLI QSVNFWYVLV 

      6010       6020       6030       6040       6050       6060 
MNDEHTERRY LLFFLLSWGL PAFVVILLIV ILKGIYHQSM SQIYGLIHGD LCFIPNVYAA 

      6070       6080       6090       6100       6110       6120 
LFTAALVPLT CLVVVFVVFI HAYQVKPQWK AYDDVFRGRT NAAEIPLILY LFALISVTWL 

      6130       6140       6150       6160       6170       6180 
WGGLHMAYRH FWMLVLFVIF NSLQGLYVFM VYFILHNQMC CPMKASYTVE MNGHPGPSTA 

      6190       6200       6210       6220       6230       6240 
FFTPGSGMPP AGGEISKSTQ NLIGAMEEVP PDWERASFQQ GSQASPDLKP SPQNGATFPS 

      6250       6260       6270       6280       6290       6300 
SGGYGQGSLI ADEESQEFDD LIFALKTGAG LSVSDNESGQ GSQEGGTLTD SQIVELRRIP 


IADTHL 

« Hide

Isoform 2 (VLGR1a) [UniParc].

Checksum: FB25C8F0D003EB47
Show »

FASTA1,967217,183
Isoform 3 (VLGR1c) [UniParc].

Checksum: 0D3B4F197CF169D8
Show »

FASTA2,306252,843
Isoform 4 [UniParc].

Checksum: D213A1B3948A9453
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FASTA1,466162,038

References

« Hide 'large scale' references
[1]"Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain."
Nikkila H., McMillan D.R., Nunez B.S., Pascoe L., Curnow K.M., White P.C.
Mol. Endocrinol. 14:1351-1364(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLY-5344, TISSUE SPECIFICITY.
[2]"Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system."
McMillan D.R., Kayes-Wandover K.M., Richardson J.A., White P.C.
J. Biol. Chem. 277:785-792(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLY-5344, DEVELOPMENTAL STAGE.
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 413-6306 (ISOFORM 4), VARIANT PHE-1093.
Tissue: Brain.
[5]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2436-4042 (ISOFORM 1), VARIANTS SER-2584 AND LYS-3471.
Tissue: Amygdala.
[6]"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5107-6306 (ISOFORMS 1/2), VARIANT GLY-5344.
Tissue: Brain.
[7]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[8]"The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1."
van Wijk E., van der Zwaag B., Peters T., Zimmermann U., Te Brinke H., Kersten F.F.J., Maerker T., Aller E., Hoefsloot L.H., Cremers C.W.R.J., Cremers F.P.M., Wolfrum U., Knipper M., Roepman R., Kremer H.
Hum. Mol. Genet. 15:751-765(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH WHRN.
[9]"A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures."
Nakayama J., Fu Y.H., Clark A.M., Nakahara S., Hamano K., Iwasaki N., Matsui A., Arinami T., Ptacek L.J.
Ann. Neurol. 52:654-657(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE INVOLVEMENT IN FAMILIAL FEBRILE CONVULSIONS 4.
[10]"Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II."
Weston M.D., Luijendijk M.W.J., Humphrey K.D., Moeller C., Kimberling W.J.
Am. J. Hum. Genet. 74:357-366(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN USH2C, VARIANTS ARG-127; LYS-249; PHE-1093; MET-1927; ILE-1951; ASP-1985; LEU-1987; PHE-2004; CYS-2232; SER-2345; ALA-2379; SER-2584; LEU-2764; THR-2803; VAL-3217; ASP-3248; LYS-3471 AND GLY-5344.
[11]"PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome."
Ebermann I., Phillips J.B., Liebau M.C., Koenekoop R.K., Schermer B., Lopez I., Schafer E., Roux A.F., Dafinger C., Bernd A., Zrenner E., Claustres M., Blanco B., Nurnberg G., Nurnberg P., Ruland R., Westerfield M., Benzing T., Bolz H.J.
J. Clin. Invest. 120:1812-1823(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PDZD7.
[12]"Non-USH2A mutations in USH2 patients."
Besnard T., Vache C., Baux D., Larrieu L., Abadie C., Blanchet C., Odent S., Blanchet P., Calvas P., Hamel C., Dollfus H., Lina-Granade G., Lespinasse J., David A., Isidor B., Morin G., Malcolm S., Tuffery-Giraud S., Claustres M., Roux A.F.
Hum. Mutat. 33:504-510(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS USH2C TRP-4789 AND ARG-5978.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF055084 mRNA. Translation: AAD55586.1.
AF435925 mRNA. Translation: AAL30811.1. Frameshift.
AC027323 Genomic DNA. No translation available.
AC034215 Genomic DNA. No translation available.
AC074132 Genomic DNA. No translation available.
AC093281 Genomic DNA. No translation available.
AC093529 Genomic DNA. No translation available.
AC094109 Genomic DNA. No translation available.
AC099512 Genomic DNA. No translation available.
AB075823 mRNA. Translation: BAB85529.1.
AL136541 mRNA. Translation: CAB66476.2. Sequence problems.
AB014586 mRNA. Translation: BAA31661.2.
CCDSCCDS47246.1. [Q8WXG9-1]
RefSeqNP_115495.3. NM_032119.3. [Q8WXG9-1]
UniGeneHs.591777.

3D structure databases

ProteinModelPortalQ8WXG9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8WXG9. 1 interaction.
MINTMINT-8330032.
STRING9606.ENSP00000384582.

Protein family/group databases

TCDB2.A.19.3.6. the ca(2+):cation antiporter (caca) family.
GPCRDBSearch...

PTM databases

PhosphoSiteQ8WXG9.

Polymorphism databases

DMDM327478512.

Proteomic databases

PaxDbQ8WXG9.
PRIDEQ8WXG9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000405460; ENSP00000384582; ENSG00000164199. [Q8WXG9-1]
ENST00000425867; ENSP00000392618; ENSG00000164199. [Q8WXG9-2]
GeneID84059.
KEGGhsa:84059.
UCSCuc003kju.3. human. [Q8WXG9-1]
uc003kjw.3. human. [Q8WXG9-2]

Organism-specific databases

CTD84059.
GeneCardsGC05P089891.
GeneReviewsGPR98.
H-InvDBHIX0005029.
HGNCHGNC:17416. GPR98.
MIM602851. gene.
604352. phenotype.
605472. phenotype.
neXtProtNX_Q8WXG9.
Orphanet231178. Usher syndrome type 2.
HUGESearch...
Search...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000088618.
HOVERGENHBG081572.
InParanoidQ8WXG9.
KOK18263.
OMANDDPFGV.
OrthoDBEOG7DRJ24.
PhylomeDBQ8WXG9.
TreeFamTF331149.

Gene expression databases

ArrayExpressQ8WXG9.
BgeeQ8WXG9.
CleanExHS_GPR98.
GenevestigatorQ8WXG9.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR003644. Calx_beta.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR009039. EAR.
IPR005492. EPTP.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR026919. GPR98.
IPR000203. GPS.
[Graphical view]
PANTHERPTHR11878:SF20. PTHR11878:SF20. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF03160. Calx-beta. 16 hits.
PF03736. EPTP. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
SMARTSM00237. Calx_beta. 19 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50912. EAR. 5 hits.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPR98. human.
GeneWikiGPR98.
GenomeRNAi84059.
NextBio73207.
PROQ8WXG9.
SOURCESearch...

Entry information

Entry nameGPR98_HUMAN
AccessionPrimary (citable) accession number: Q8WXG9
Secondary accession number(s): O75171 expand/collapse secondary AC list , Q8TF58, Q9H0X5, Q9UL61
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries