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Q8WXG9

- GPR98_HUMAN

UniProt

Q8WXG9 - GPR98_HUMAN

Protein

G-protein coupled receptor 98

Gene

GPR98

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Receptor that may have an important role in the development of the central nervous system.

    GO - Molecular functioni

    1. calcium ion binding Source: HGNC
    2. G-protein coupled receptor activity Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
    2. G-protein coupled receptor signaling pathway Source: GDB
    3. inner ear receptor stereocilium organization Source: Ensembl
    4. maintenance of organ identity Source: HGNC
    5. nervous system development Source: UniProtKB
    6. neurological system process Source: HGNC
    7. neuropeptide signaling pathway Source: InterPro
    8. photoreceptor cell maintenance Source: HGNC
    9. sensory perception of light stimulus Source: HGNC
    10. sensory perception of sound Source: HGNC
    11. single organismal cell-cell adhesion Source: UniProtKB
    12. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    Calcium

    Protein family/group databases

    TCDBi2.A.19.3.6. the ca(2+):cation antiporter (caca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 98
    Alternative name(s):
    Monogenic audiogenic seizure susceptibility protein 1 homolog
    Usher syndrome type-2C protein
    Very large G-protein coupled receptor 1
    Gene namesi
    Name:GPR98
    Synonyms:KIAA0686, KIAA1943, MASS1, VLGR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:17416. GPR98.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: HGNC
    2. cytoplasm Source: HGNC
    3. extracellular vesicular exosome Source: UniProt
    4. integral component of membrane Source: GDB
    5. membrane Source: UniProtKB
    6. plasma membrane Source: UniProtKB-SubCell
    7. receptor complex Source: MGI
    8. stereocilia ankle link complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Usher syndrome 2C (USH2C) [MIM:605472]: USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4789 – 47891R → W in USH2C. 1 Publication
    VAR_068032
    Natural varianti5978 – 59781H → R in USH2C. 1 Publication
    VAR_068033
    Febrile seizures, familial, 4 (FEB4) [MIM:604352]: Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
    Note: The disease may be caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Deafness, Retinitis pigmentosa, Usher syndrome

    Organism-specific databases

    MIMi604352. phenotype.
    605472. phenotype.
    Orphaneti231178. Usher syndrome type 2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 63066277G-protein coupled receptor 98PRO_0000232735Add
    BLAST

    Proteomic databases

    PaxDbiQ8WXG9.
    PRIDEiQ8WXG9.

    PTM databases

    PhosphoSiteiQ8WXG9.

    Expressioni

    Tissue specificityi

    Expressed at low levels in adult tissues.1 Publication

    Developmental stagei

    Isoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively.1 Publication

    Gene expression databases

    ArrayExpressiQ8WXG9.
    BgeeiQ8WXG9.
    CleanExiHS_GPR98.
    GenevestigatoriQ8WXG9.

    Interactioni

    Subunit structurei

    Interacts with WHRN. Interacts with PDZD7.2 Publications

    Protein-protein interaction databases

    IntActiQ8WXG9. 1 interaction.
    MINTiMINT-8330032.
    STRINGi9606.ENSP00000384582.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXG9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 59085879ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini5930 – 593910CytoplasmicSequence Analysis
    Topological domaini5961 – 597919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini6001 – 601010CytoplasmicSequence Analysis
    Topological domaini6032 – 605928ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini6081 – 610424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini6126 – 61338ExtracellularSequence Analysis
    Topological domaini6155 – 6306152CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5909 – 592921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei5940 – 596021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei5980 – 600021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei6011 – 603121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei6060 – 608021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei6105 – 612521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei6134 – 615421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini77 – 11640Calx-beta 1Add
    BLAST
    Domaini195 – 23541Calx-beta 2Add
    BLAST
    Domaini321 – 36242Calx-beta 3Add
    BLAST
    Domaini447 – 48842Calx-beta 4Add
    BLAST
    Domaini706 – 74540Calx-beta 5Add
    BLAST
    Domaini821 – 86141Calx-beta 6Add
    BLAST
    Domaini938 – 97942Calx-beta 7Add
    BLAST
    Domaini1051 – 109242Calx-beta 8Add
    BLAST
    Domaini1167 – 120842Calx-beta 9Add
    BLAST
    Domaini1504 – 154441Calx-beta 10Add
    BLAST
    Domaini1626 – 166641Calx-beta 11Add
    BLAST
    Domaini1767 – 180842Calx-beta 12Add
    BLAST
    Domaini1911 – 194131Calx-beta 13Add
    BLAST
    Domaini2038 – 207841Calx-beta 14Add
    BLAST
    Domaini2165 – 220541Calx-beta 15Add
    BLAST
    Domaini2283 – 232341Calx-beta 16Add
    BLAST
    Domaini2501 – 254141Calx-beta 17Add
    BLAST
    Domaini2635 – 267541Calx-beta 18Add
    BLAST
    Domaini2749 – 278941Calx-beta 19Add
    BLAST
    Domaini2884 – 292441Calx-beta 20Add
    BLAST
    Domaini3007 – 304741Calx-beta 21Add
    BLAST
    Domaini3131 – 317141Calx-beta 22Add
    BLAST
    Repeati3189 – 324153EAR 1Add
    BLAST
    Repeati3296 – 334550EAR 2Add
    BLAST
    Repeati3347 – 339347EAR 3Add
    BLAST
    Repeati3394 – 343946EAR 4Add
    BLAST
    Repeati3440 – 348849EAR 5Add
    BLAST
    Repeati3491 – 353444EAR 6Add
    BLAST
    Domaini3584 – 362542Calx-beta 23Add
    BLAST
    Domaini3700 – 373940Calx-beta 24Add
    BLAST
    Domaini3834 – 387542Calx-beta 25Add
    BLAST
    Domaini3965 – 400541Calx-beta 26Add
    BLAST
    Domaini4082 – 412241Calx-beta 27Add
    BLAST
    Domaini4199 – 423941Calx-beta 28Add
    BLAST
    Domaini4313 – 435341Calx-beta 29Add
    BLAST
    Domaini4448 – 448841Calx-beta 30Add
    BLAST
    Domaini4570 – 461243Calx-beta 31Add
    BLAST
    Domaini4693 – 473442Calx-beta 32Add
    BLAST
    Domaini5053 – 509442Calx-beta 33Add
    BLAST
    Domaini5291 – 533343Calx-beta 34Add
    BLAST
    Domaini5427 – 546842Calx-beta 35Add
    BLAST
    Domaini5853 – 590250GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 35 Calx-beta domains.Curated
    Contains 6 EAR repeats.PROSITE-ProRule annotation
    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000088618.
    HOVERGENiHBG081572.
    InParanoidiQ8WXG9.
    KOiK18263.
    OMAiNDDPFGV.
    OrthoDBiEOG7DRJ24.
    PhylomeDBiQ8WXG9.
    TreeFamiTF331149.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR003644. Calx_beta.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR009039. EAR.
    IPR005492. EPTP.
    IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR026919. GPR98.
    IPR000203. GPS.
    [Graphical view]
    PANTHERiPTHR11878:SF20. PTHR11878:SF20. 1 hit.
    PfamiPF00002. 7tm_2. 1 hit.
    PF03160. Calx-beta. 16 hits.
    PF03736. EPTP. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view]
    SMARTiSM00237. Calx_beta. 19 hits.
    SM00303. GPS. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50912. EAR. 5 hits.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WXG9-1) [UniParc]FASTAAdd to Basket

    Also known as: VLGR1b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MSVFLGPGMP SASLLVNLLS ALLILFVFGE TEIRFTGQTE FVVNETSTTV     50
    IRLIIERIGE PANVTAIVSL YGEDAGDFFD TYAAAFIPAG ETNRTVYIAV 100
    CDDDLPEPDE TFIFHLTLQK PSANVKLGWP RTVTVTILSN DNAFGIISFN 150
    MLPSIAVSEP KGRNESMPLT LIREKGTYGM VMVTFEVEGG PNPPDEDLSP 200
    VKGNITFPPG RATVIYNLTV LDDEVPENDE IFLIQLKSVE GGAEINTSRN 250
    SIEIIIKKND SPVRFLQSIY LVPEEDHILI IPVVRGKDNN GNLIGSDEYE 300
    VSISYAVTTG NSTAHAQQNL DFIDLQPNTT VVFPPFIHES HLKFQIVDDT 350
    IPEIAESFHI MLLKDTLQGD AVLISPSVVQ VTIKPNDKPY GVLSFNSVLF 400
    ERTVIIDEDR ISRYEEITVV RNGGTHGNVS ANWVLTRNST DPSPVTADIR 450
    PSSGVLHFAQ GQMLATIPLT VVDDDLPEEA EAYLLQILPH TIRGGAEVSE 500
    PAELLFYIQD SDDVYGLITF FPMENQKIES SPGERYLSLS FTRLGGTKGD 550
    VRLLYSVLYI PAGAVDPLQA KEGILNISRR NDLIFPEQKT QVTTKLPIRN 600
    DAFLQNGAHF LVQLETVELL NIIPLIPPIS PRFGEICNIS LLVTPAIANG 650
    EIGFLSNLPI ILHEPEDFAA EVVYIPLHRD GTDGQATVYW SLKPSGFNSK 700
    AVTPDDIGPF NGSVLFLSGQ SDTTINITIK GDDIPEMNET VTLSLDRVNV 750
    ENQVLKSGYT SRDLIILEND DPGGVFEFSP ASRGPYVIKE GESVELHIIR 800
    SRGSLVKQFL HYRVEPRDSN EFYGNTGVLE FKPGEREIVI TLLARLDGIP 850
    ELDEHYWVVL SSHGERESKL GSATIVNITI LKNDDPHGII EFVSDGLIVM 900
    INESKGDAIY SAVYDVVRNR GNFGDVSVSW VVSPDFTQDV FPVQGTVVFG 950
    DQEFSKNITI YSLPDEIPEE MEEFTVILLN GTGGAKVGNR TTATLRIRRN 1000
    DDPIYFAEPR VVRVQEGETA NFTVLRNGSV DVTCMVQYAT KDGKATARER 1050
    DFIPVEKGET LIFEVGSRQQ SISIFVNEDG IPETDEPFYI ILLNSTGDTV 1100
    VYQYGVATVI IEANDDPNGI FSLEPIDKAV EEGKTNAFWI LRHRGYFGSV 1150
    SVSWQLFQND SALQPGQEFY ETSGTVNFMD GEEAKPIILH AFPDKIPEFN 1200
    EFYFLKLVNI SGGSPGPGGQ LAETNLQVTV MVPFNDDPFG VFILDPECLE 1250
    REVAEDVLSE DDMSYITNFT ILRQQGVFGD VQLGWEILSS EFPAGLPPMI 1300
    DFLLVGIFPT TVHLQQHMRR HHSGTDALYF TGLEGAFGTV NPKYHPSRNN 1350
    TIANFTFSAW VMPNANTNGF IIAKDDGNGS IYYGVKIQTN ESHVTLSLHY 1400
    KTLGSNATYI AKTTVMKYLE ESVWLHLLII LEDGIIEFYL DGNAMPRGIK 1450
    SLKGEAITDG PGILRIGAGI NGNDRFTGLM QDVRSYERKL TLEEIYELHA 1500
    MPAKSDLHPI SGYLEFRQGE TNKSFIISAR DDNDEEGEEL FILKLVSVYG 1550
    GARISEENTT ARLTIQKSDN ANGLFGFTGA CIPEIAEEGS TISCVVERTR 1600
    GALDYVHVFY TISQIETDGI NYLVDDFANA SGTITFLPWQ RSEVLNIYVL 1650
    DDDIPELNEY FRVTLVSAIP GDGKLGSTPT SGASIDPEKE TTDITIKASD 1700
    HPYGLLQFST GLPPQPKDAM TLPASSVPHI TVEEEDGEIR LLVIRAQGLL 1750
    GRVTAEFRTV SLTAFSPEDY QNVAGTLEFQ PGERYKYIFI NITDNSIPEL 1800
    EKSFKVELLN LEGGVAELFR VDGSGSGDGD MEFFLPTIHK RASLGVASQI 1850
    LVTIAASDHA HGVFEFSPES LFVSGTEPED GYSTVTLNVI RHHGTLSPVT 1900
    LHWNIDSDPD GDLAFTSGNI TFEIGQTSAN ITVEILPDED PELDKAFSVS 1950
    VLSVSSGSLG AHINATLTVL ASDDPYGIFI FSEKNRPVKV EEATQNITLS 2000
    IIRLKGLMGK VLVSYATLDD MEKPPYFPPN LARATQGRDY IPASGFALFG 2050
    ANQSEATIAI SILDDDEPER SESVFIELLN STLVAKVQSR SIPNSPRLGP 2100
    KVETIAQLII IANDDAFGTL QLSAPIVRVA ENHVGPIINV TRTGGAFADV 2150
    SVKFKAVPIT AIAGEDYSIA SSDVVLLEGE TSKAVPIYVI NDIYPELEES 2200
    FLVQLMNETT GGARLGALTE AVIIIEASDD PYGLFGFQIT KLIVEEPEFN 2250
    SVKVNLPIIR NSGTLGNVTV QWVATINGQL ATGDLRVVSG NVTFAPGETI 2300
    QTLLLEVLAD DVPEIEEVIQ VQLTDASGGG TIGLDRIANI IIPANDDPYG 2350
    TVAFAQMVYR VQEPLERSSC ANITVRRSGG HFGRLLLFYS TSDIDVVALA 2400
    MEEGQDLLSY YESPIQGVPD PLWRTWMNVS AVGEPLYTCA TLCLKEQACS 2450
    AFSFFSASEG PQCFWMTSWI SPAVNNSDFW TYRKNMTRVA SLFSGQAVAG 2500
    SDYEPVTRQW AIMQEGDEFA NLTVSILPDD FPEMDESFLI SLLEVHLMNI 2550
    SASLKNQPTI GQPNISTVVI ALNGDAFGVF VIYNISPNTS EDGLFVEVQE 2600
    QPQTLVELMI HRTGGSLGQV AVEWRVVGGT ATEGLDFIGA GEILTFAEGE 2650
    TKKTVILTIL DDSEPEDDES IIVSLVYTEG GSRILPSSDT VRVNILANDN 2700
    VAGIVSFQTA SRSVIGHEGE ILQFHVIRTF PGRGNVTVNW KIIGQNLELN 2750
    FANFSGQLFF PEGSLNTTLF VHLLDDNIPE EKEVYQVILY DVRTQGVPPA 2800
    GIALLDAQGY AAVLTVEASD EPHGVLNFAL SSRFVLLQEA NITIQLFINR 2850
    EFGSLGAINV TYTTVPGMLS LKNQTVGNLA EPEVDFVPII GFLILEEGET 2900
    AAAINITILE DDVPELEEYF LVNLTYVGLT MAASTSFPPR LDSEGLTAQV 2950
    IIDANDGARG VIEWQQSRFE VNETHGSLTL VAQRSREPLG HVSLFVYAQN 3000
    LEAQVGLDYI FTPMILHFAD GERYKNVNIM ILDDDIPEGD EKFQLILTNP 3050
    SPGLELGKNT IALIIVLAND DGPGVLSFNN SEHFFLREPT ALYVQESVAV 3100
    LYIVREPAQG LFGTVTVQFI VTEVNSSNES KDLTPSKGYI VLEEGVRFKA 3150
    LQISAILDTE PEMDEYFVCT LFNPTGGARL GVHVQTLITV LQNQAPLGLF 3200
    SISAVENRAT SIDIEEANRT VYLNVSRTNG IDLAVSVQWE TVSETAFGMR 3250
    GMDVVFSVFQ SFLDESASGW CFFTLENLIY GIMLRKSSVT VYRWQGIFIP 3300
    VEDLNIENPK TCEAFNIGFS PYFVITHEER NEEKPSLNSV FTFTSGFKLF 3350
    LVQTIIILES SQVRYFTSDS QDYLIIASQR DDSELTQVFR WNGGSFVLHQ 3400
    KLPVRGVLTV ALFNKGGSVF LAISQANARL NSLLFRWSGS GFINFQEVPV 3450
    SGTTEVEALS SANDIYLIFA ENVFLGDQNS IDIFIWEMGQ SSFRYFQSVD 3500
    FAAVNRIHSF TPASGIAHIL LIGQDMSALY CWNSERNQFS FVLEVPSAYD 3550
    VASVTVKSLN SSKNLIALVG AHSHIYELAY ISSHSDFIPS SGELIFEPGE 3600
    REATIAVNIL DDTVPEKEES FKVQLKNPKG GAEIGINDSV TITILSNDDA 3650
    YGIVAFAQNS LYKQVEEMEQ DSLVTLNVER LKGTYGRITI AWEADGSISD 3700
    IFPTSGVILF TEGQVLSTIT LTILADNIPE LSEVVIVTLT RITTEGVEDS 3750
    YKGATIDQDR SKSVITTLPN DSPFGLVGWR AASVFIRVAE PKENTTTLQL 3800
    QIARDKGLLG DIAIHLRAQP NFLLHVDNQA TENEDYVLQE TIIIMKENIK 3850
    EAHAEVSILP DDLPELEEGF IVTITEVNLV NSDFSTGQPS VRRPGMEIAE 3900
    IMIEENDDPR GIFMFHVTRG AGEVITAYEV PPPLNVLQVP VVRLAGSFGA 3950
    VNVYWKASPD SAGLEDFKPS HGILEFADKQ VTAMIEITII DDAEFELTET 4000
    FNISLISVAG GGRLGDDVVV TVVIPQNDSP FGVFGFEEKT VMIDESLSSD 4050
    DPDSYVTLTV VRSPGGKGTV RLEWTIDEKA KHNLSPLNGT LHFDETESQK 4100
    TIVLHTLQDT VLEEDRRFTI QLISIDEVEI SPVKGSASII IRGDKRASGE 4150
    VGIAPSSRHI LIGEPSAKYN GTAIISLVRG PGILGEVTVF WRIFPPSVGE 4200
    FAETSGKLTM RDEQSAVIVV IQALNDDIPE EKSFYEFQLT AVSEGGVLSE 4250
    SSSTANITVV ASDSPYGRFA FSHEQLRVSE AQRVNITIIR SSGDFGHVRL 4300
    WYKTMSGTAE AGLDFVPAAG ELLFEAGEMR KSLHVEILDD DYPEGPEEFS 4350
    LTITKVELQG RGYDFTIQEN GLQIDQPPEI GNISIVRIII MKNDNAEGII 4400
    EFDPKYTAFE VEEDVGLIMI PVVRLHGTYG YVTADFISQS SSASPGGVDY 4450
    ILHGSTVTFQ HGQNLSFINI SIIDDNESEF EEPIEILLTG ATGGAVLGRH 4500
    LVSRIIIAKS DSPFGVIRFL NQSKISIANP NSTMILSLVL ERTGGLLGEI 4550
    QVNWETVGPN SQEALLPQNR DIADPVSGLF YFGEGEGGVR TIILTIYPHE 4600
    EIEVEETFII KLHLVKGEAK LDSRAKDVTL TIQEFGDPNG VVQFAPETLS 4650
    KKTYSEPLAL EGPLLITFFV RRVKGTFGEI MVYWELSSEF DITEDFLSTS 4700
    GFFTIADGES EASFDVHLLP DEVPEIEEDY VIQLVSVEGG AELDLEKSIT 4750
    WFSVYANDDP HGVFALYSDR QSILIGQNLI RSIQINITRL AGTFGDVAVG 4800
    LRISSDHKEQ PIVTENAERQ LVVKDGATYK VDVVPIKNQV FLSLGSNFTL 4850
    QLVTVMLVGG RFYGMPTILQ EAKSAVLPVS EKAANSQVGF ESTAFQLMNI 4900
    TAGTSHVMIS RRGTYGALSV AWTTGYAPGL EIPEFIVVGN MTPTLGSLSF 4950
    SHGEQRKGVF LWTFPSPGWP EAFVLHLSGV QSSAPGGAQL RSGFIVAEIE 5000
    PMGVFQFSTS SRNIIVSEDT QMIRLHVQRL FGFHSDLIKV SYQTTAGSAK 5050
    PLEDFEPVQN GELFFQKFQT EVDFEITIIN DQLSEIEEFF YINLTSVEIR 5100
    GLQKFDVNWS PRLNLDFSVA VITILDNDDL AGMDISFPET TVAVAVDTTL 5150
    IPVETESTTY LSTSKTTTIL QPTNVVAIVT EATGVSAIPE KLVTLHGTPA 5200
    VSEKPDVATV TANVSIHGTF SLGPSIVYIE EEMKNGTFNT AEVLIRRTGG 5250
    FTGNVSITVK TFGERCAQME PNALPFRGIY GISNLTWAVE EEDFEEQTLT 5300
    LIFLDGERER KVSVQILDDD EPEGQEFFYV FLTNPQGGAQ IVEEKDDTGF 5350
    AAFAMVIITG SDLHNGIIGF SEESQSGLEL REGAVMRRLH LIVTRQPNRA 5400
    FEDVKVFWRV TLNKTVVVLQ KDGVNLVEEL QSVSGTTTCT MGQTKCFISI 5450
    ELKPEKVPQV EVYFFVELYE ATAGAAINNS ARFAQIKILE SDESQSLVYF 5500
    SVGSRLAVAH KKATLISLQV ARDSGTGLMM SVNFSTQELR SAETIGRTII 5550
    SPAISGKDFV ITEGTLVFEP GQRSTVLDVI LTPETGSLNS FPKRFQIVLF 5600
    DPKGGARIDK VYGTANITLV SDADSQAIWG LADQLHQPVN DDILNRVLHT 5650
    ISMKVATENT DEQLSAMMHL IEKITTEGKI QAFSVASRTL FYEILCSLIN 5700
    PKRKDTRGFS HFAEVTENFA FSLLTNVTCG SPGEKSKTIL DSCPYLSILA 5750
    LHWYPQQING HKFEGKEGDY IRIPERLLDV QDAEIMAGKS TCKLVQFTEY 5800
    SSQQWFISGN NLPTLKNKVL SLSVKGQSSQ LLTNDNEVLY RIYAAEPRII 5850
    PQTSLCLLWN QAAASWLSDS QFCKVVEETA DYVECACSHM SVYAVYARTD 5900
    NLSSYNEAFF TSGFICISGL CLAVLSHIFC ARYSMFAAKL LTHMMAASLG 5950
    TQILFLASAY ASPQLAEESC SAMAAVTHYL YLCQFSWMLI QSVNFWYVLV 6000
    MNDEHTERRY LLFFLLSWGL PAFVVILLIV ILKGIYHQSM SQIYGLIHGD 6050
    LCFIPNVYAA LFTAALVPLT CLVVVFVVFI HAYQVKPQWK AYDDVFRGRT 6100
    NAAEIPLILY LFALISVTWL WGGLHMAYRH FWMLVLFVIF NSLQGLYVFM 6150
    VYFILHNQMC CPMKASYTVE MNGHPGPSTA FFTPGSGMPP AGGEISKSTQ 6200
    NLIGAMEEVP PDWERASFQQ GSQASPDLKP SPQNGATFPS SGGYGQGSLI 6250
    ADEESQEFDD LIFALKTGAG LSVSDNESGQ GSQEGGTLTD SQIVELRRIP 6300
    IADTHL 6306
    Length:6,306
    Mass (Da):693,069
    Last modified:April 5, 2011 - v2
    Checksum:i30168F374ACEEF24
    GO
    Isoform 2 (identifier: Q8WXG9-2) [UniParc]FASTAAdd to Basket

    Also known as: VLGR1a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4339: Missing.
         4340-4359: DDYPEGPEEFSLTITKVELQ → MQLCIFCCCCILFYFDLYDF

    Show »
    Length:1,967
    Mass (Da):217,183
    Checksum:iFB25C8F0D003EB47
    GO
    Isoform 3 (identifier: Q8WXG9-3) [UniParc]FASTAAdd to Basket

    Also known as: VLGR1c

    The sequence of this isoform differs from the canonical sequence as follows:
         2296-2306: PGETIQTLLLE → RVVSGYPSATN
         2307-6306: Missing.

    Show »
    Length:2,306
    Mass (Da):252,843
    Checksum:i0D3B4F197CF169D8
    GO
    Isoform 4 (identifier: Q8WXG9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1461-1466: PGILRI → EGHHHN
         1467-6306: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,466
    Mass (Da):162,038
    Checksum:iD213A1B3948A9453
    GO

    Sequence cautioni

    The sequence AAL30811.1 differs from that shown. Reason: Frameshift at positions 3524 and 3532.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti107 – 1071E → G in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti219 – 2191T → A in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti257 – 2571K → E in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti435 – 4373LTR → VTP in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti471 – 4722VV → GG in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti534 – 5341E → G in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti747 – 7471R → W in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti1096 – 10961T → P in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti1099 – 10991T → P in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti1232 – 12321V → A in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti1320 – 13201R → G in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti1340 – 13423VNP → GNS in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti1347 – 13471S → F in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti3230 – 32301G → D in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti3528 – 35281A → T in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti3552 – 35521A → V in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti4244 – 42441E → G in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti5427 – 54271V → M in AAD55586. (PubMed:10976914)Curated
    Sequence conflicti5427 – 54271V → M in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti5427 – 54271V → M in BAA31661. (PubMed:9734811)Curated
    Sequence conflicti5876 – 58761V → I in AAD55586. (PubMed:10976914)Curated
    Sequence conflicti5876 – 58761V → I in AAL30811. (PubMed:11606593)Curated
    Sequence conflicti5876 – 58761V → I in BAA31661. (PubMed:9734811)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti127 – 1271L → R.1 Publication
    Corresponds to variant rs41311333 [ dbSNP | Ensembl ].
    VAR_025995
    Natural varianti249 – 2491R → K.1 Publication
    Corresponds to variant rs41303344 [ dbSNP | Ensembl ].
    VAR_025996
    Natural varianti551 – 5511V → A.
    Corresponds to variant rs6889939 [ dbSNP | Ensembl ].
    VAR_046346
    Natural varianti1093 – 10931L → F.2 Publications
    Corresponds to variant rs2366777 [ dbSNP | Ensembl ].
    VAR_025997
    Natural varianti1187 – 11871I → V.
    Corresponds to variant rs16868935 [ dbSNP | Ensembl ].
    VAR_046347
    Natural varianti1916 – 19161T → I.
    Corresponds to variant rs35791889 [ dbSNP | Ensembl ].
    VAR_046348
    Natural varianti1927 – 19271T → M.1 Publication
    Corresponds to variant rs17544552 [ dbSNP | Ensembl ].
    VAR_025998
    Natural varianti1951 – 19511V → I.1 Publication
    Corresponds to variant rs4916684 [ dbSNP | Ensembl ].
    VAR_025999
    Natural varianti1985 – 19851N → D.1 Publication
    Corresponds to variant rs41303352 [ dbSNP | Ensembl ].
    VAR_026000
    Natural varianti1987 – 19871P → L.1 Publication
    Corresponds to variant rs4916685 [ dbSNP | Ensembl ].
    VAR_026001
    Natural varianti2004 – 20041L → F.1 Publication
    Corresponds to variant rs16868972 [ dbSNP | Ensembl ].
    VAR_026002
    Natural varianti2097 – 20971R → C.
    Corresponds to variant rs16868974 [ dbSNP | Ensembl ].
    VAR_046349
    Natural varianti2232 – 22321Y → C.1 Publication
    Corresponds to variant rs10037067 [ dbSNP | Ensembl ].
    VAR_026003
    Natural varianti2345 – 23451N → S.1 Publication
    Corresponds to variant rs2366926 [ dbSNP | Ensembl ].
    VAR_026004
    Natural varianti2379 – 23791G → A.1 Publication
    VAR_026005
    Natural varianti2584 – 25841N → S.2 Publications
    Corresponds to variant rs1878878 [ dbSNP | Ensembl ].
    VAR_026006
    Natural varianti2764 – 27641S → L.1 Publication
    Corresponds to variant rs16869016 [ dbSNP | Ensembl ].
    VAR_026007
    Natural varianti2803 – 28031A → T.1 Publication
    Corresponds to variant rs111033530 [ dbSNP | Ensembl ].
    VAR_026008
    Natural varianti3094 – 30941V → I.
    Corresponds to variant rs13157270 [ dbSNP | Ensembl ].
    VAR_046350
    Natural varianti3217 – 32171A → V.1 Publication
    Corresponds to variant rs114137750 [ dbSNP | Ensembl ].
    VAR_026009
    Natural varianti3248 – 32481G → D.1 Publication
    Corresponds to variant rs16869032 [ dbSNP | Ensembl ].
    VAR_026010
    Natural varianti3347 – 33471F → L.
    Corresponds to variant rs10067636 [ dbSNP | Ensembl ].
    VAR_046351
    Natural varianti3471 – 34711E → K.2 Publications
    Corresponds to variant rs2366928 [ dbSNP | Ensembl ].
    VAR_026011
    Natural varianti3867 – 38671E → A.
    Corresponds to variant rs16869088 [ dbSNP | Ensembl ].
    VAR_046352
    Natural varianti3868 – 38681E → A.
    Corresponds to variant rs16869088 [ dbSNP | Ensembl ].
    VAR_055933
    Natural varianti4789 – 47891R → W in USH2C. 1 Publication
    VAR_068032
    Natural varianti5344 – 53441E → G.4 Publications
    Corresponds to variant rs2438374 [ dbSNP | Ensembl ].
    VAR_026012
    Natural varianti5437 – 54371T → A.
    VAR_026013
    Natural varianti5978 – 59781H → R in USH2C. 1 Publication
    VAR_068033

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 43394339Missing in isoform 2. 2 PublicationsVSP_017947Add
    BLAST
    Alternative sequencei1461 – 14666PGILRI → EGHHHN in isoform 4. 1 PublicationVSP_035313
    Alternative sequencei1467 – 63064840Missing in isoform 4. 1 PublicationVSP_035314Add
    BLAST
    Alternative sequencei2296 – 230611PGETIQTLLLE → RVVSGYPSATN in isoform 3. 1 PublicationVSP_017948Add
    BLAST
    Alternative sequencei2307 – 63064000Missing in isoform 3. 1 PublicationVSP_017949Add
    BLAST
    Alternative sequencei4340 – 435920DDYPE…KVELQ → MQLCIFCCCCILFYFDLYDF in isoform 2. 2 PublicationsVSP_017950Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055084 mRNA. Translation: AAD55586.1.
    AF435925 mRNA. Translation: AAL30811.1. Frameshift.
    AC027323 Genomic DNA. No translation available.
    AC034215 Genomic DNA. No translation available.
    AC074132 Genomic DNA. No translation available.
    AC093281 Genomic DNA. No translation available.
    AC093529 Genomic DNA. No translation available.
    AC094109 Genomic DNA. No translation available.
    AC099512 Genomic DNA. No translation available.
    AB075823 mRNA. Translation: BAB85529.1.
    AL136541 mRNA. Translation: CAB66476.2. Sequence problems.
    AB014586 mRNA. Translation: BAA31661.2.
    CCDSiCCDS47246.1. [Q8WXG9-1]
    RefSeqiNP_115495.3. NM_032119.3. [Q8WXG9-1]
    UniGeneiHs.591777.

    Genome annotation databases

    EnsembliENST00000405460; ENSP00000384582; ENSG00000164199. [Q8WXG9-1]
    ENST00000425867; ENSP00000392618; ENSG00000164199. [Q8WXG9-2]
    GeneIDi84059.
    KEGGihsa:84059.
    UCSCiuc003kju.3. human. [Q8WXG9-1]
    uc003kjw.3. human. [Q8WXG9-2]

    Polymorphism databases

    DMDMi327478512.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055084 mRNA. Translation: AAD55586.1 .
    AF435925 mRNA. Translation: AAL30811.1 . Frameshift.
    AC027323 Genomic DNA. No translation available.
    AC034215 Genomic DNA. No translation available.
    AC074132 Genomic DNA. No translation available.
    AC093281 Genomic DNA. No translation available.
    AC093529 Genomic DNA. No translation available.
    AC094109 Genomic DNA. No translation available.
    AC099512 Genomic DNA. No translation available.
    AB075823 mRNA. Translation: BAB85529.1 .
    AL136541 mRNA. Translation: CAB66476.2 . Sequence problems.
    AB014586 mRNA. Translation: BAA31661.2 .
    CCDSi CCDS47246.1. [Q8WXG9-1 ]
    RefSeqi NP_115495.3. NM_032119.3. [Q8WXG9-1 ]
    UniGenei Hs.591777.

    3D structure databases

    ProteinModelPortali Q8WXG9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8WXG9. 1 interaction.
    MINTi MINT-8330032.
    STRINGi 9606.ENSP00000384582.

    Protein family/group databases

    TCDBi 2.A.19.3.6. the ca(2+):cation antiporter (caca) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8WXG9.

    Polymorphism databases

    DMDMi 327478512.

    Proteomic databases

    PaxDbi Q8WXG9.
    PRIDEi Q8WXG9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000405460 ; ENSP00000384582 ; ENSG00000164199 . [Q8WXG9-1 ]
    ENST00000425867 ; ENSP00000392618 ; ENSG00000164199 . [Q8WXG9-2 ]
    GeneIDi 84059.
    KEGGi hsa:84059.
    UCSCi uc003kju.3. human. [Q8WXG9-1 ]
    uc003kjw.3. human. [Q8WXG9-2 ]

    Organism-specific databases

    CTDi 84059.
    GeneCardsi GC05P089891.
    GeneReviewsi GPR98.
    H-InvDB HIX0005029.
    HGNCi HGNC:17416. GPR98.
    MIMi 602851. gene.
    604352. phenotype.
    605472. phenotype.
    neXtProti NX_Q8WXG9.
    Orphaneti 231178. Usher syndrome type 2.
    HUGEi Search...
    Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000088618.
    HOVERGENi HBG081572.
    InParanoidi Q8WXG9.
    KOi K18263.
    OMAi NDDPFGV.
    OrthoDBi EOG7DRJ24.
    PhylomeDBi Q8WXG9.
    TreeFami TF331149.

    Miscellaneous databases

    ChiTaRSi GPR98. human.
    GeneWikii GPR98.
    GenomeRNAii 84059.
    NextBioi 73207.
    PROi Q8WXG9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WXG9.
    Bgeei Q8WXG9.
    CleanExi HS_GPR98.
    Genevestigatori Q8WXG9.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR003644. Calx_beta.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR009039. EAR.
    IPR005492. EPTP.
    IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR026919. GPR98.
    IPR000203. GPS.
    [Graphical view ]
    PANTHERi PTHR11878:SF20. PTHR11878:SF20. 1 hit.
    Pfami PF00002. 7tm_2. 1 hit.
    PF03160. Calx-beta. 16 hits.
    PF03736. EPTP. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    SMARTi SM00237. Calx_beta. 19 hits.
    SM00303. GPS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50912. EAR. 5 hits.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain."
      Nikkila H., McMillan D.R., Nunez B.S., Pascoe L., Curnow K.M., White P.C.
      Mol. Endocrinol. 14:1351-1364(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLY-5344, TISSUE SPECIFICITY.
    2. "Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system."
      McMillan D.R., Kayes-Wandover K.M., Richardson J.A., White P.C.
      J. Biol. Chem. 277:785-792(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLY-5344, DEVELOPMENTAL STAGE.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 413-6306 (ISOFORM 4), VARIANT PHE-1093.
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2436-4042 (ISOFORM 1), VARIANTS SER-2584 AND LYS-3471.
      Tissue: Amygdala.
    6. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5107-6306 (ISOFORMS 1/2), VARIANT GLY-5344.
      Tissue: Brain.
    7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    8. "The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1."
      van Wijk E., van der Zwaag B., Peters T., Zimmermann U., Te Brinke H., Kersten F.F.J., Maerker T., Aller E., Hoefsloot L.H., Cremers C.W.R.J., Cremers F.P.M., Wolfrum U., Knipper M., Roepman R., Kremer H.
      Hum. Mol. Genet. 15:751-765(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WHRN.
    9. "A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures."
      Nakayama J., Fu Y.H., Clark A.M., Nakahara S., Hamano K., Iwasaki N., Matsui A., Arinami T., Ptacek L.J.
      Ann. Neurol. 52:654-657(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN FAMILIAL FEBRILE CONVULSIONS 4.
    10. "Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II."
      Weston M.D., Luijendijk M.W.J., Humphrey K.D., Moeller C., Kimberling W.J.
      Am. J. Hum. Genet. 74:357-366(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN USH2C, VARIANTS ARG-127; LYS-249; PHE-1093; MET-1927; ILE-1951; ASP-1985; LEU-1987; PHE-2004; CYS-2232; SER-2345; ALA-2379; SER-2584; LEU-2764; THR-2803; VAL-3217; ASP-3248; LYS-3471 AND GLY-5344.
    11. Cited for: INTERACTION WITH PDZD7.
    12. Cited for: VARIANTS USH2C TRP-4789 AND ARG-5978.

    Entry informationi

    Entry nameiGPR98_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXG9
    Secondary accession number(s): O75171
    , Q8TF58, Q9H0X5, Q9UL61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    By far is the largest known cell surface protein.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3