Q8WXG8 (S100Z_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein S100-Z

Alternative name(s):
S100 calcium-binding protein Z

Gene names

Name:

S100Z

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homodimer. Interacts with S100P. Ref.1
Tissue specificity	Highest level of expression in spleen and leukocytes. Ref.1
Miscellaneous	This protein binds two calcium ions.
Sequence similarities	Belongs to the S-100 family. Contains 2 EF-hand domains.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Calcium
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 99	98	Protein S100-Z		PRO_0000144033
Regions
	Domain	13 – 48	36	EF-hand 1
	Domain	50 – 85	36	EF-hand 2
	Calcium binding	20 – 33	14	1; low affinity Ref.1
	Calcium binding	63 – 74	12	2; high affinity Ref.1
Natural variations
	Natural variant	23	1	E → A. Ref.1 Ref.3 Corresponds to variant rs1320308 [ dbSNP | Ensembl ].		VAR_060484

Sequences

	Sequence		Length	Mass (Da)
	Q8WXG8 [UniParc]. Last modified May 18, 2010. Version 4. Checksum: 2D019EE19C68E994	FASTA	99	11,620
	10 20 30 40 50 60 MPTQLEMAMD TMIRIFHRYS GKERKRFKLS KGELKLLLQR ELTEFLSCQK ETQLVDKIVQ 70 80 90 DLDANKDNEV DFNEFVVMVA ALTVACNDYF VEQLKKKGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins." Gribenko A.V., Hopper J.E., Makhatadze G.I. Biochemistry 40:15538-15548(2001) [PubMed: 11747429] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-21, SUBUNIT, CALCIUM-BINDING, TISSUE SPECIFICITY, INTERACTION WITH S100P, VARIANT ALA-23. Tissue: Prostate.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-23. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF437876 mRNA. Translation: AAL30893.1. AC114962 Genomic DNA. No translation available. BC022320 mRNA. Translation: AAH22320.1.
IPI	IPI00216284.
RefSeq	NP_570128.2. NM_130772.3.
UniGene	Hs.482563.
3D structure databases
ProteinModelPortal	Q8WXG8.
SMR	Q8WXG8. Positions 2-97.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WXG8.
Polymorphism databases
DMDM	296453019.
Proteomic databases
PRIDE	Q8WXG8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317593; ENSP00000320430; ENSG00000171643. ENST00000429334; ENSP00000411873; ENSG00000171643.
GeneID	170591.
KEGG	hsa:170591.
UCSC	uc003kep.1. human.
Organism-specific databases
CTD	170591.
GeneCards	GC05P076181.
H-InvDB	HIX0019841.
HGNC	HGNC:30367. S100Z.
MIM	610103. gene.
neXtProt	NX_Q8WXG8.
PharmGKB	PA134902118.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG20618.
GeneTree	ENSGT00600000084162.
HOGENOM	HBG716817.
HOVERGEN	HBG001479.
InParanoid	Q8WXG8.
OMA	TQLEMAM.
OrthoDB	EOG46T331.
PhylomeDB	Q8WXG8.
Gene expression databases
ArrayExpress	Q8WXG8.
Bgee	Q8WXG8.
CleanEx	HS_S100Z.
Genevestigator	Q8WXG8.
GermOnline	ENSG00000171643. Homo sapiens.
Family and domain databases
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR001751. S100/CaBP-9k_CS. IPR013787. S100_Ca-bd_sub. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
Pfam	PF01023. S_100. 1 hit. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 1 hit. PS00303. S100_CABP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	89053.
SOURCE	Search...

Entry information

Entry name

S100Z_HUMAN

Accession

Primary (citable) accession number: Q8WXG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 86 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.