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Protein

Protein S100-Z

Gene

S100Z

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinityAdd
BLAST
Calcium bindingi63 – 74122; high affinityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-Z
Alternative name(s):
S100 calcium-binding protein Z
Gene namesi
Name:S100Z
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30367. S100Z.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134902118.

Polymorphism and mutation databases

BioMutaiS100Z.
DMDMi296453019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 9998Protein S100-ZPRO_0000144033Add
BLAST

Proteomic databases

PaxDbiQ8WXG8.
PRIDEiQ8WXG8.

Expressioni

Tissue specificityi

Highest level of expression in spleen and leukocytes.1 Publication

Gene expression databases

BgeeiQ8WXG8.
CleanExiHS_S100Z.
GenevisibleiQ8WXG8. HS.

Organism-specific databases

HPAiHPA047432.

Interactioni

Subunit structurei

Homodimer. Interacts with S100P.1 Publication

Protein-protein interaction databases

BioGridi128065. 1 interaction.
STRINGi9606.ENSP00000320430.

Structurei

3D structure databases

ProteinModelPortaliQ8WXG8.
SMRiQ8WXG8. Positions 2-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 4836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZ5W. Eukaryota.
ENOG4111NIQ. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiQ8WXG8.
OMAiCKEGDRF.
OrthoDBiEOG7R833W.
PhylomeDBiQ8WXG8.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028490. S100Z.
[Graphical view]
PANTHERiPTHR11639:SF72. PTHR11639:SF72. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WXG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTQLEMAMD TMIRIFHRYS GKERKRFKLS KGELKLLLQR ELTEFLSCQK
60 70 80 90
ETQLVDKIVQ DLDANKDNEV DFNEFVVMVA ALTVACNDYF VEQLKKKGK
Length:99
Mass (Da):11,620
Last modified:May 18, 2010 - v4
Checksum:i2D019EE19C68E994
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231E → A.2 Publications
Corresponds to variant rs1320308 [ dbSNP | Ensembl ].
VAR_060484

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF437876 mRNA. Translation: AAL30893.1.
AC114962 Genomic DNA. No translation available.
BC022320 mRNA. Translation: AAH22320.1.
CCDSiCCDS43333.1.
RefSeqiNP_570128.2. NM_130772.3.
XP_011541541.1. XM_011543239.1.
XP_011541542.1. XM_011543240.1.
XP_011541543.1. XM_011543241.1.
XP_011541544.1. XM_011543242.1.
XP_011541545.1. XM_011543243.1.
XP_011541546.1. XM_011543244.1.
XP_011541547.1. XM_011543245.1.
UniGeneiHs.482563.

Genome annotation databases

EnsembliENST00000317593; ENSP00000320430; ENSG00000171643.
ENST00000513010; ENSP00000426768; ENSG00000171643.
ENST00000613039; ENSP00000483535; ENSG00000171643.
GeneIDi170591.
KEGGihsa:170591.
UCSCiuc003kep.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF437876 mRNA. Translation: AAL30893.1.
AC114962 Genomic DNA. No translation available.
BC022320 mRNA. Translation: AAH22320.1.
CCDSiCCDS43333.1.
RefSeqiNP_570128.2. NM_130772.3.
XP_011541541.1. XM_011543239.1.
XP_011541542.1. XM_011543240.1.
XP_011541543.1. XM_011543241.1.
XP_011541544.1. XM_011543242.1.
XP_011541545.1. XM_011543243.1.
XP_011541546.1. XM_011543244.1.
XP_011541547.1. XM_011543245.1.
UniGeneiHs.482563.

3D structure databases

ProteinModelPortaliQ8WXG8.
SMRiQ8WXG8. Positions 2-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128065. 1 interaction.
STRINGi9606.ENSP00000320430.

Polymorphism and mutation databases

BioMutaiS100Z.
DMDMi296453019.

Proteomic databases

PaxDbiQ8WXG8.
PRIDEiQ8WXG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317593; ENSP00000320430; ENSG00000171643.
ENST00000513010; ENSP00000426768; ENSG00000171643.
ENST00000613039; ENSP00000483535; ENSG00000171643.
GeneIDi170591.
KEGGihsa:170591.
UCSCiuc003kep.1. human.

Organism-specific databases

CTDi170591.
GeneCardsiS100Z.
H-InvDBHIX0019841.
HGNCiHGNC:30367. S100Z.
HPAiHPA047432.
MIMi610103. gene.
neXtProtiNX_Q8WXG8.
PharmGKBiPA134902118.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ5W. Eukaryota.
ENOG4111NIQ. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiQ8WXG8.
OMAiCKEGDRF.
OrthoDBiEOG7R833W.
PhylomeDBiQ8WXG8.
TreeFamiTF332727.

Miscellaneous databases

GenomeRNAii170591.
NextBioi89053.
PROiQ8WXG8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WXG8.
CleanExiHS_S100Z.
GenevisibleiQ8WXG8. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028490. S100Z.
[Graphical view]
PANTHERiPTHR11639:SF72. PTHR11639:SF72. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins."
    Gribenko A.V., Hopper J.E., Makhatadze G.I.
    Biochemistry 40:15538-15548(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-21, SUBUNIT, CALCIUM-BINDING, TISSUE SPECIFICITY, INTERACTION WITH S100P, VARIANT ALA-23.
    Tissue: Prostate.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-23.
    Tissue: Testis.

Entry informationi

Entry nameiS100Z_HUMAN
AccessioniPrimary (citable) accession number: Q8WXG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 117 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein binds two calcium ions.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.