ID CRGN_HUMAN Reviewed; 182 AA. AC Q8WXF5; Q496G6; DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 24-JAN-2024, entry version 148. DE RecName: Full=Gamma-crystallin N {ECO:0000305}; DE AltName: Full=Gamma-N-crystallin {ECO:0000305}; GN Name=CRYGN {ECO:0000312|HGNC:HGNC:20458}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RC TISSUE=Testis; RX PubMed=15853812; DOI=10.1111/j.1742-4658.2005.04655.x; RA Wistow G., Wyatt K., David L., Gao C., Bateman O., Bernstein S., RA Tomarev S., Segovia L., Slingsby C., Vihtelic T.; RT "Gamma-N-crystallin and the evolution of the betagamma-crystallin RT superfamily in vertebrates."; RL FEBS J. 272:2276-2291(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBUNIT: Monomer. {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q8WXF5-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8WXF5-2; Sequence=VSP_029507, VSP_029508; CC -!- TISSUE SPECIFICITY: Not specifically expressed in eye. CC {ECO:0000269|PubMed:15853812}. CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}. CC -!- CAUTION: In contrast to the orthologous protein found in other species, CC the C-terminal part differs and lacks the fourth beta/gamma crystallin CC 'Greek key' domain. Moreover, its non-specific tissue specificity CC suggests that it may have lost its function (PubMed:15853812). CC {ECO:0000305|PubMed:15853812}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF445455; AAL40968.1; -; mRNA. DR EMBL; CH471173; EAW53992.1; -; Genomic_DNA. DR EMBL; BC100878; AAI00879.1; -; mRNA. DR EMBL; BC100879; AAI00880.1; -; mRNA. DR EMBL; BC100880; AAI00881.1; -; mRNA. DR EMBL; BC100881; AAI00882.1; -; mRNA. DR CCDS; CCDS5926.1; -. [Q8WXF5-1] DR CCDS; CCDS78289.1; -. [Q8WXF5-2] DR RefSeq; NP_001295221.1; NM_001308292.1. [Q8WXF5-2] DR RefSeq; NP_653328.1; NM_144727.2. [Q8WXF5-1] DR RefSeq; XP_016867262.1; XM_017011773.1. [Q8WXF5-2] DR AlphaFoldDB; Q8WXF5; -. DR SMR; Q8WXF5; -. DR BioGRID; 127571; 12. DR STRING; 9606.ENSP00000338613; -. DR GlyGen; Q8WXF5; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q8WXF5; -. DR PhosphoSitePlus; Q8WXF5; -. DR BioMuta; CRYGN; -. DR DMDM; 74727349; -. DR PaxDb; 9606-ENSP00000338613; -. DR TopDownProteomics; Q8WXF5-1; -. [Q8WXF5-1] DR Antibodypedia; 64394; 66 antibodies from 16 providers. DR DNASU; 155051; -. DR Ensembl; ENST00000337323.3; ENSP00000338613.3; ENSG00000127377.10. [Q8WXF5-1] DR Ensembl; ENST00000491928.1; ENSP00000420157.1; ENSG00000127377.10. [Q8WXF5-2] DR GeneID; 155051; -. DR KEGG; hsa:155051; -. DR MANE-Select; ENST00000337323.3; ENSP00000338613.3; NM_144727.3; NP_653328.1. DR UCSC; uc003wke.4; human. [Q8WXF5-1] DR AGR; HGNC:20458; -. DR CTD; 155051; -. DR GeneCards; CRYGN; -. DR HGNC; HGNC:20458; CRYGN. DR HPA; ENSG00000127377; Tissue enriched (thyroid). DR MIM; 609603; gene. DR neXtProt; NX_Q8WXF5; -. DR PharmGKB; PA134870586; -. DR VEuPathDB; HostDB:ENSG00000127377; -. DR eggNOG; ENOG502QV8X; Eukaryota. DR GeneTree; ENSGT00940000159301; -. DR HOGENOM; CLU_081883_1_0_1; -. DR InParanoid; Q8WXF5; -. DR OrthoDB; 3998747at2759; -. DR PhylomeDB; Q8WXF5; -. DR PathwayCommons; Q8WXF5; -. DR BioGRID-ORCS; 155051; 10 hits in 1138 CRISPR screens. DR GenomeRNAi; 155051; -. DR Pharos; Q8WXF5; Tdark. DR PRO; PR:Q8WXF5; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; Q8WXF5; Protein. DR Bgee; ENSG00000127377; Expressed in right lobe of thyroid gland and 91 other cell types or tissues. DR ExpressionAtlas; Q8WXF5; baseline and differential. DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central. DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central. DR GO; GO:0007601; P:visual perception; IBA:GO_Central. DR Gene3D; 2.60.20.10; Crystallins; 2. DR InterPro; IPR001064; Beta/gamma_crystallin. DR InterPro; IPR011024; G_crystallin-like. DR PANTHER; PTHR11818; BETA/GAMMA CRYSTALLIN; 1. DR PANTHER; PTHR11818:SF22; GAMMA-CRYSTALLIN N; 1. DR Pfam; PF00030; Crystall; 1. DR PRINTS; PR01367; BGCRYSTALLIN. DR SMART; SM00247; XTALbg; 1. DR SUPFAM; SSF49695; gamma-Crystallin-like; 1. DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 3. DR Genevisible; Q8WXF5; HS. PE 2: Evidence at transcript level; KW Alternative splicing; Reference proteome; Repeat. FT CHAIN 1..182 FT /note="Gamma-crystallin N" FT /id="PRO_0000311281" FT DOMAIN 6..46 FT /note="Beta/gamma crystallin 'Greek key' 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028" FT DOMAIN 47..89 FT /note="Beta/gamma crystallin 'Greek key' 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028" FT DOMAIN 95..136 FT /note="Beta/gamma crystallin 'Greek key' 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028" FT REGION 153..182 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 91..125 FT /note="HGEHFRLEIFEGCNFTGQCLEFLEDSPFLQSRGWV -> VSGPVHRRLSLPA FT GGTEGQPWQTVARNRGAWSSRL (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_029507" FT VAR_SEQ 126..182 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_029508" SQ SEQUENCE 182 AA; 20624 MW; 761F381A8BDFDDF1 CRC64; MAQRSGKITL YEGKHFTGQK LEVFGDCDNF QDRGFMNRVN SIHVESGAWV CFNHPDFRGQ QFILEHGDYP DFFRWNSHSD HMGSCRPVGM HGEHFRLEIF EGCNFTGQCL EFLEDSPFLQ SRGWVKNCVN TIKVYGDGAA WSPRSFGAED FQLSSSLQSD QGPEEATTKP ATTQPPFLTA NL //