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Q8WXF3

- REL3_HUMAN

UniProt

Q8WXF3 - REL3_HUMAN

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Protein

Relaxin-3

Gene

RLN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_21314. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3
Alternative name(s):
Insulin-like peptide INSL7
Short name:
Insulin-like peptide 7
Prorelaxin H3
Cleaved into the following 2 chains:
Gene namesi
Name:RLN3
Synonyms:INSL7, RXN3, ZINS4
ORF Names:UNQ6188/PRO20213
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:17135. RLN3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Peptidei26 – 5227Relaxin-3 B chainBy similarityPRO_0000016082Add
BLAST
Propeptidei55 – 11864Connecting peptideBy similarityPRO_0000016083Add
BLAST
Peptidei119 – 14224Relaxin-3 A chainBy similarityPRO_0000016084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 129Interchain (between B and A chains)1 Publication
Disulfide bondi47 ↔ 142Interchain (between B and A chains)1 Publication
Disulfide bondi128 ↔ 1331 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ8WXF3.
PRIDEiQ8WXF3.

PTM databases

PhosphoSiteiQ8WXF3.

Expressioni

Gene expression databases

BgeeiQ8WXF3.
CleanExiHS_RLN3.
ExpressionAtlasiQ8WXF3. baseline.
GenevestigatoriQ8WXF3.

Organism-specific databases

HPAiHPA043731.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Binary interactionsi

WithEntry#Exp.IntActNotes
RXFP4Q8TDU99EBI-9519546,EBI-9519524

Protein-protein interaction databases

BioGridi125590. 3 interactions.
IntActiQ8WXF3. 1 interaction.
STRINGi9606.ENSP00000307040.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 324Combined sources
Helixi37 – 4711Combined sources
Helixi120 – 13011Combined sources
Helixi135 – 1395Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FHWNMR-A119-142[»]
B26-52[»]
2K1VNMR-B26-52[»]
ProteinModelPortaliQ8WXF3.
SMRiQ8WXF3. Positions 26-52.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WXF3.

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45013.
GeneTreeiENSGT00510000048203.
HOGENOMiHOG000111888.
HOVERGENiHBG045048.
InParanoidiQ8WXF3.
KOiK05255.
OMAiEARASPY.
OrthoDBiEOG7H1JNG.
PhylomeDBiQ8WXF3.
TreeFamiTF333404.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WXF3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARYMLLLLL AVWVLTGELW PGAEARAAPY GVRLCGREFI RAVIFTCGGS
60 70 80 90 100
RWRRSDILAH EAMGDTFPDA DADEDSLAGE LDEAMGSSEW LALTKSPQAF
110 120 130 140
YRGRPSWQGT PGVLRGSRDV LAGLSSSCCK WGCSKSEISS LC
Length:142
Mass (Da):15,451
Last modified:March 1, 2002 - v1
Checksum:i23A3E095034B31E4
GO

Sequence cautioni

The sequence AAQ88548.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447451 mRNA. Translation: AAL40345.1.
AB076563 mRNA. Translation: BAC53758.1.
AY358181 mRNA. Translation: AAQ88548.1. Different initiation.
CCDSiCCDS12302.1.
RefSeqiNP_543140.1. NM_080864.2.
UniGeneiHs.352155.

Genome annotation databases

EnsembliENST00000431365; ENSP00000397415; ENSG00000171136.
GeneIDi117579.
KEGGihsa:117579.
UCSCiuc002mxw.1. human.

Polymorphism databases

DMDMi37999891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447451 mRNA. Translation: AAL40345.1 .
AB076563 mRNA. Translation: BAC53758.1 .
AY358181 mRNA. Translation: AAQ88548.1 . Different initiation.
CCDSi CCDS12302.1.
RefSeqi NP_543140.1. NM_080864.2.
UniGenei Hs.352155.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FHW NMR - A 119-142 [» ]
B 26-52 [» ]
2K1V NMR - B 26-52 [» ]
ProteinModelPortali Q8WXF3.
SMRi Q8WXF3. Positions 26-52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125590. 3 interactions.
IntActi Q8WXF3. 1 interaction.
STRINGi 9606.ENSP00000307040.

PTM databases

PhosphoSitei Q8WXF3.

Polymorphism databases

DMDMi 37999891.

Proteomic databases

PaxDbi Q8WXF3.
PRIDEi Q8WXF3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000431365 ; ENSP00000397415 ; ENSG00000171136 .
GeneIDi 117579.
KEGGi hsa:117579.
UCSCi uc002mxw.1. human.

Organism-specific databases

CTDi 117579.
GeneCardsi GC19P014137.
HGNCi HGNC:17135. RLN3.
HPAi HPA043731.
MIMi 606855. gene.
neXtProti NX_Q8WXF3.
PharmGKBi PA34401.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45013.
GeneTreei ENSGT00510000048203.
HOGENOMi HOG000111888.
HOVERGENi HBG045048.
InParanoidi Q8WXF3.
KOi K05255.
OMAi EARASPY.
OrthoDBi EOG7H1JNG.
PhylomeDBi Q8WXF3.
TreeFami TF333404.

Enzyme and pathway databases

Reactomei REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_21314. Relaxin receptors.

Miscellaneous databases

EvolutionaryTracei Q8WXF3.
GenomeRNAii 117579.
NextBioi 80214.
PROi Q8WXF3.
SOURCEi Search...

Gene expression databases

Bgeei Q8WXF3.
CleanExi HS_RLN3.
ExpressionAtlasi Q8WXF3. baseline.
Genevestigatori Q8WXF3.

Family and domain databases

InterProi IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 2 hits.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens insulin homolog polypeptide."
    Holloway J.L., Lok S., Jaspers S.R.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-34 AND 119-127.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2."
    Sudo S., Kumagai J., Nishi S., Layfield S., Ferraro T., Bathgate R.A.D., Hsueh A.J.W.
    J. Biol. Chem. 278:7855-7862(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LGR7.
  5. "Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135."
    Liu C., Eriste E., Sutton S., Chen J., Roland B., Kuei C., Farmer N., Joernvall H., Sillard R., Lovenberg T.W.
    J. Biol. Chem. 278:50754-50764(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GPCR135.
  6. Cited for: INTERACTION WITH GPCR142.
  7. "Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3."
    Rosengren K.J., Lin F., Bathgate R.A., Tregear G.W., Daly N.L., Wade J.D., Craik D.J.
    J. Biol. Chem. 281:5845-5851(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 26-142, DISULFIDE BONDS.

Entry informationi

Entry nameiREL3_HUMAN
AccessioniPrimary (citable) accession number: Q8WXF3
Secondary accession number(s): Q6UXW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3