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Q8WXF1

- PSPC1_HUMAN

UniProt

Q8WXF1 - PSPC1_HUMAN

Protein

Paraspeckle component 1

Gene

PSPC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line By similarity. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer By similarity. Together with NONO, required for the formation of nuclear paraspeckles.By similarity1 Publication

    GO - Molecular functioni

    1. core promoter binding Source: UniProtKB
    2. nucleotide binding Source: InterPro
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. regulation of circadian rhythm Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paraspeckle component 1
    Alternative name(s):
    Paraspeckle protein 1
    Gene namesi
    Name:PSPC1
    Synonyms:PSP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:20320. PSPC1.

    Subcellular locationi

    Nucleusnucleolus. Nucleus matrix By similarity. Cytoplasm By similarity. Nucleus speckle
    Note: In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear matrix Source: UniProtKB-SubCell
    3. nuclear speck Source: UniProtKB-SubCell
    4. nucleolus Source: HPA
    5. nucleus Source: HPA
    6. paraspeckles Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi119 – 1191F → A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps; when associated with A-121; A-198 and A-200. 1 Publication
    Mutagenesisi121 – 1211F → A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps; when associated with A-119; A-198 and A-200. 1 Publication
    Mutagenesisi198 – 1981K → A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps; when associated with A-119; A-121 and A-200. 1 Publication
    Mutagenesisi200 – 2001F → A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps; when associated with A-119; A-121 and A-198. 1 Publication
    Mutagenesisi275 – 2751Y → A: Abolishes interaction with NONO and localization in nuclear paraspeckles; when associated with A-279. 1 Publication
    Mutagenesisi279 – 2791W → A: Abolishes interaction with NONO and localization in nuclear paraspeckles; when associated with A-275. 1 Publication

    Organism-specific databases

    PharmGKBiPA134968603.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Paraspeckle component 1PRO_0000297540Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei409 – 4091Phosphoserine1 Publication
    Modified residuei473 – 4731Phosphoserine1 Publication
    Modified residuei477 – 4771Phosphoserine1 Publication
    Modified residuei509 – 5091Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8WXF1.
    PaxDbiQ8WXF1.
    PRIDEiQ8WXF1.

    PTM databases

    PhosphoSiteiQ8WXF1.

    Expressioni

    Tissue specificityi

    Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.1 Publication

    Gene expression databases

    BgeeiQ8WXF1.
    CleanExiHS_PSPC1.
    GenevestigatoriQ8WXF1.

    Organism-specific databases

    HPAiHPA038904.

    Interactioni

    Subunit structurei

    Forms heterodimers with NONO; this involves formation of a coiled coil domain by helices from both proteins. Found in a RNP complex with CAT2 transcribed nuclear RNA (CTN-RNA). Interaction with NONO is required for its targeting to paraspeckles and perinucleolar caps. Interacts with SFPQ By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NONOQ152336EBI-1392258,EBI-350527

    Protein-protein interaction databases

    BioGridi120558. 21 interactions.
    DIPiDIP-39028N.
    IntActiQ8WXF1. 9 interactions.
    MINTiMINT-1395719.
    STRINGi9606.ENSP00000343966.

    Structurei

    Secondary structure

    1
    523
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi80 – 823
    Beta strandi83 – 886
    Helixi95 – 1017
    Helixi102 – 1054
    Beta strandi109 – 1146
    Turni115 – 1184
    Beta strandi119 – 1235
    Helixi127 – 13711
    Beta strandi148 – 1514
    Beta strandi155 – 1628
    Helixi169 – 1768
    Helixi177 – 1793
    Beta strandi182 – 1909
    Beta strandi195 – 20511
    Helixi206 – 21813
    Beta strandi221 – 2266
    Beta strandi231 – 2344
    Beta strandi238 – 2425
    Helixi246 – 2483
    Helixi253 – 2597
    Beta strandi263 – 2653
    Helixi271 – 31848

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3SDEX-ray1.90A61-320[»]
    ProteinModelPortaliQ8WXF1.
    SMRiQ8WXF1. Positions 66-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 15473RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini156 – 23782RRM 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 358234Sufficient for paraspeckles localizationAdd
    BLAST
    Regioni231 – 358128Sufficient for perinucleolar caps localization and interaction with NONOAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili283 – 37795Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi394 – 516123Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PSPC family.Curated
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG298586.
    HOGENOMiHOG000231095.
    HOVERGENiHBG009801.
    InParanoidiQ8WXF1.
    OMAiMDNREQE.
    OrthoDBiEOG7327P0.
    PhylomeDBiQ8WXF1.
    TreeFamiTF315795.

    Family and domain databases

    Gene3Di3.30.70.330. 2 hits.
    InterProiIPR012975. NOPS.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF08075. NOPS. 1 hit.
    PF00076. RRM_1. 2 hits.
    [Graphical view]
    SMARTiSM00360. RRM. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WXF1-1) [UniParc]FASTAAdd to Basket

    Also known as: PSP1-alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMLRGNLKQV RIEKNPARLR ALESAVGESE PAAAAAMALA LAGEPAPPAP    50
    APPEDHPDEE MGFTIDIKSF LKPGEKTYTQ RCRLFVGNLP TDITEEDFKR 100
    LFERYGEPSE VFINRDRGFG FIRLESRTLA EIAKAELDGT ILKSRPLRIR 150
    FATHGAALTV KNLSPVVSNE LLEQAFSQFG PVEKAVVVVD DRGRATGKGF 200
    VEFAAKPPAR KALERCGDGA FLLTTTPRPV IVEPMEQFDD EDGLPEKLMQ 250
    KTQQYHKERE QPPRFAQPGT FEFEYASRWK ALDEMEKQQR EQVDRNIREA 300
    KEKLEAEMEA ARHEHQLMLM RQDLMRRQEE LRRLEELRNQ ELQKRKQIQL 350
    RHEEEHRRRE EEMIRHREQE ELRRQQEGFK PNYMENREQE MRMGDMGPRG 400
    AINMGDAFSP APAGNQGPPP MMGMNMNNRA TIPGPPMGPG PAMGPEGAAN 450
    MGTPMMPDNG AVHNDRFPQG PPSQMGSPMG SRTGSETPQA PMSGVGPVSG 500
    GPGGFGRGSQ GGNFEGPNKR RRY 523
    Length:523
    Mass (Da):58,744
    Last modified:March 1, 2002 - v1
    Checksum:i3A8C44079D64BBF0
    GO
    Isoform 2 (identifier: Q8WXF1-2) [UniParc]FASTAAdd to Basket

    Also known as: PSP1-beta

    The sequence of this isoform differs from the canonical sequence as follows:
         387-393: REQEMRM → GDKRKCG
         394-523: Missing.

    Show »
    Length:393
    Mass (Da):45,571
    Checksum:i67F1A7EBF93050B2
    GO

    Sequence cautioni

    The sequence BAA91924.1 differs from that shown. Reason: Erroneous termination at position 14. Translated as Lys.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei387 – 3937REQEMRM → GDKRKCG in isoform 2. 5 PublicationsVSP_027274
    Alternative sequencei394 – 523130Missing in isoform 2. 5 PublicationsVSP_027275Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF448795 mRNA. Translation: AAL59601.1.
    AF449627 mRNA. Translation: AAL59602.1.
    AK001817 mRNA. Translation: BAA91924.1. Sequence problems.
    AL354808 Genomic DNA. Translation: CAI41004.1.
    AL354808 Genomic DNA. Translation: CAI41005.1.
    CH471075 Genomic DNA. Translation: EAX08232.1.
    BC014184 mRNA. Translation: AAH14184.2.
    CR457272 mRNA. Translation: CAG33553.1.
    AL834505 mRNA. Translation: CAD39162.1.
    CCDSiCCDS41870.1. [Q8WXF1-1]
    RefSeqiNP_001035879.1. NM_001042414.2. [Q8WXF1-1]
    XP_006719907.1. XM_006719844.1. [Q8WXF1-1]
    UniGeneiHs.213198.

    Genome annotation databases

    EnsembliENST00000338910; ENSP00000343966; ENSG00000121390. [Q8WXF1-1]
    ENST00000471658; ENSP00000436038; ENSG00000121390. [Q8WXF1-2]
    ENST00000492741; ENSP00000435921; ENSG00000121390. [Q8WXF1-2]
    GeneIDi55269.
    KEGGihsa:55269.
    UCSCiuc021rgx.1. human. [Q8WXF1-1]

    Polymorphism databases

    DMDMi74762636.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF448795 mRNA. Translation: AAL59601.1 .
    AF449627 mRNA. Translation: AAL59602.1 .
    AK001817 mRNA. Translation: BAA91924.1 . Sequence problems.
    AL354808 Genomic DNA. Translation: CAI41004.1 .
    AL354808 Genomic DNA. Translation: CAI41005.1 .
    CH471075 Genomic DNA. Translation: EAX08232.1 .
    BC014184 mRNA. Translation: AAH14184.2 .
    CR457272 mRNA. Translation: CAG33553.1 .
    AL834505 mRNA. Translation: CAD39162.1 .
    CCDSi CCDS41870.1. [Q8WXF1-1 ]
    RefSeqi NP_001035879.1. NM_001042414.2. [Q8WXF1-1 ]
    XP_006719907.1. XM_006719844.1. [Q8WXF1-1 ]
    UniGenei Hs.213198.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3SDE X-ray 1.90 A 61-320 [» ]
    ProteinModelPortali Q8WXF1.
    SMRi Q8WXF1. Positions 66-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120558. 21 interactions.
    DIPi DIP-39028N.
    IntActi Q8WXF1. 9 interactions.
    MINTi MINT-1395719.
    STRINGi 9606.ENSP00000343966.

    PTM databases

    PhosphoSitei Q8WXF1.

    Polymorphism databases

    DMDMi 74762636.

    Proteomic databases

    MaxQBi Q8WXF1.
    PaxDbi Q8WXF1.
    PRIDEi Q8WXF1.

    Protocols and materials databases

    DNASUi 55269.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338910 ; ENSP00000343966 ; ENSG00000121390 . [Q8WXF1-1 ]
    ENST00000471658 ; ENSP00000436038 ; ENSG00000121390 . [Q8WXF1-2 ]
    ENST00000492741 ; ENSP00000435921 ; ENSG00000121390 . [Q8WXF1-2 ]
    GeneIDi 55269.
    KEGGi hsa:55269.
    UCSCi uc021rgx.1. human. [Q8WXF1-1 ]

    Organism-specific databases

    CTDi 55269.
    GeneCardsi GC13M020249.
    H-InvDB HIX0011177.
    HGNCi HGNC:20320. PSPC1.
    HPAi HPA038904.
    MIMi 612408. gene.
    neXtProti NX_Q8WXF1.
    PharmGKBi PA134968603.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG298586.
    HOGENOMi HOG000231095.
    HOVERGENi HBG009801.
    InParanoidi Q8WXF1.
    OMAi MDNREQE.
    OrthoDBi EOG7327P0.
    PhylomeDBi Q8WXF1.
    TreeFami TF315795.

    Miscellaneous databases

    ChiTaRSi PSPC1. human.
    GenomeRNAii 55269.
    NextBioi 59380.
    PROi Q8WXF1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WXF1.
    CleanExi HS_PSPC1.
    Genevestigatori Q8WXF1.

    Family and domain databases

    Gene3Di 3.30.70.330. 2 hits.
    InterProi IPR012975. NOPS.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF08075. NOPS. 1 hit.
    PF00076. RRM_1. 2 hits.
    [Graphical view ]
    SMARTi SM00360. RRM. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 21-83; 105-124; 135-143; 185-194; 199-210; 252-259; 265-289; 327-345; 352-357; 366-374 AND 483-507, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Skin.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-523 (ISOFORM 2).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-523 (ISOFORM 2).
      Tissue: Kidney.
    8. "P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner."
      Fox A.H., Bond C.S., Lamond A.I.
      Mol. Biol. Cell 16:5304-5315(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, INTERACTION WITH NONO, MUTAGENESIS OF PHE-119; PHE-121; LYS-198 AND PHE-200, SUBCELLULAR LOCATION.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-473 AND SER-477, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation."
      Passon D.M., Lee M., Rackham O., Stanley W.A., Sadowska A., Filipovska A., Fox A.H., Bond C.S.
      Proc. Natl. Acad. Sci. U.S.A. 109:4846-4850(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 61-320 IN COMPLEX WITH NONO, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-275 AND TRP-279.

    Entry informationi

    Entry nameiPSPC1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXF1
    Secondary accession number(s): Q5JTQ3
    , Q8NCZ9, Q8WXE8, Q9NV36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3