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Protein

Serine/arginine-rich splicing factor 12

Gene

SRSF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.1 Publication

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • RS domain binding Source: UniProtKB
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • mRNA 5'-splice site recognition Source: UniProtKB
  • negative regulation of mRNA splicing, via spliceosome Source: UniProtKB
  • regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
  • spliceosomal tri-snRNP complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 12
Alternative name(s):
35 kDa SR repressor protein
Short name:
SRrp35
Splicing factor, arginine/serine-rich 13B
Splicing factor, arginine/serine-rich 19
Gene namesi
Name:SRSF12
Synonyms:SFRS13B, SFRS19, SRRP35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21220. SRSF12.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165618223.

Polymorphism and mutation databases

BioMutaiSRSF12.
DMDMi47606193.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Serine/arginine-rich splicing factor 12PRO_0000081960Add
BLAST

Proteomic databases

EPDiQ8WXF0.
MaxQBiQ8WXF0.
PaxDbiQ8WXF0.
PeptideAtlasiQ8WXF0.
PRIDEiQ8WXF0.

PTM databases

iPTMnetiQ8WXF0.
PhosphoSiteiQ8WXF0.
SwissPalmiQ8WXF0.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000154548.
ExpressionAtlasiQ8WXF0. baseline and differential.
GenevisibleiQ8WXF0. HS.

Organism-specific databases

HPAiHPA049782.

Interactioni

GO - Molecular functioni

  • RS domain binding Source: UniProtKB
  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126428. 17 interactions.
IntActiQ8WXF0. 6 interactions.
STRINGi9606.ENSP00000414302.

Structurei

3D structure databases

ProteinModelPortaliQ8WXF0.
SMRiQ8WXF0. Positions 10-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 8879RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi105 – 254150Arg/Ser-rich (RS domain)Add
BLAST

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQX1. Eukaryota.
ENOG4111J16. LUCA.
GeneTreeiENSGT00700000104403.
HOVERGENiHBG107480.
InParanoidiQ8WXF0.
OMAiXSRHRRF.
OrthoDBiEOG091G13K0.
PhylomeDBiQ8WXF0.
TreeFamiTF351864.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRYTRPPNT SLFIRNVADA TRPEDLRREF GRYGPIVDVY IPLDFYTRRP
60 70 80 90 100
RGFAYVQFED VRDAEDALYN LNRKWVCGRQ IEIQFAQGDR KTPGQMKSKE
110 120 130 140 150
RHPCSPSDHR RSRSPSQRRT RSRSSSWGRN RRRSDSLKES RHRRFSYSQS
160 170 180 190 200
KSRSKSLPRR STSARQSRTP RRNFGSRGRS RSKSLQKRSK SIGKSQSSSP
210 220 230 240 250
QKQTSSGTKS RSHGRHSDSI ARSPCKSPKG YTNSETKVQT AKHSHFRSHS
260
RSRSYRHKNS W
Length:261
Mass (Da):30,512
Last modified:March 1, 2002 - v1
Checksum:iC1473A5760462E54
GO

Sequence cautioni

The sequence CAI16247 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAW48561 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631D → G in AAH21715 (PubMed:15489334).Curated
Sequence conflicti149 – 1491Q → K in AAH21715 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449428 mRNA. Translation: AAL57515.1.
AL353135 Genomic DNA. Translation: CAI16247.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW48561.1. Sequence problems.
AK314008 mRNA. Translation: BAG36719.1.
BC021715 mRNA. Translation: AAH21715.1.
CCDSiCCDS47459.1.
RefSeqiNP_542781.3. NM_080743.4.
UniGeneiHs.254414.

Genome annotation databases

EnsembliENST00000452027; ENSP00000414302; ENSG00000154548.
GeneIDi135295.
KEGGihsa:135295.
UCSCiuc063qaq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449428 mRNA. Translation: AAL57515.1.
AL353135 Genomic DNA. Translation: CAI16247.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW48561.1. Sequence problems.
AK314008 mRNA. Translation: BAG36719.1.
BC021715 mRNA. Translation: AAH21715.1.
CCDSiCCDS47459.1.
RefSeqiNP_542781.3. NM_080743.4.
UniGeneiHs.254414.

3D structure databases

ProteinModelPortaliQ8WXF0.
SMRiQ8WXF0. Positions 10-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126428. 17 interactions.
IntActiQ8WXF0. 6 interactions.
STRINGi9606.ENSP00000414302.

PTM databases

iPTMnetiQ8WXF0.
PhosphoSiteiQ8WXF0.
SwissPalmiQ8WXF0.

Polymorphism and mutation databases

BioMutaiSRSF12.
DMDMi47606193.

Proteomic databases

EPDiQ8WXF0.
MaxQBiQ8WXF0.
PaxDbiQ8WXF0.
PeptideAtlasiQ8WXF0.
PRIDEiQ8WXF0.

Protocols and materials databases

DNASUi135295.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452027; ENSP00000414302; ENSG00000154548.
GeneIDi135295.
KEGGihsa:135295.
UCSCiuc063qaq.1. human.

Organism-specific databases

CTDi135295.
GeneCardsiSRSF12.
HGNCiHGNC:21220. SRSF12.
HPAiHPA049782.
neXtProtiNX_Q8WXF0.
PharmGKBiPA165618223.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQX1. Eukaryota.
ENOG4111J16. LUCA.
GeneTreeiENSGT00700000104403.
HOVERGENiHBG107480.
InParanoidiQ8WXF0.
OMAiXSRHRRF.
OrthoDBiEOG091G13K0.
PhylomeDBiQ8WXF0.
TreeFamiTF351864.

Miscellaneous databases

GenomeRNAii135295.
PROiQ8WXF0.

Gene expression databases

BgeeiENSG00000154548.
ExpressionAtlasiQ8WXF0. baseline and differential.
GenevisibleiQ8WXF0. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRS12_HUMAN
AccessioniPrimary (citable) accession number: Q8WXF0
Secondary accession number(s): B2RA22, Q5T7K0, Q8WW25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.