Q8WXE1 (ATRIP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATR-interacting protein

Alternative name(s):
ATM and Rad3-related-interacting protein

Gene names

Name:	ATRIP
Synonyms:	AGS1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	791 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Ref.6
Subunit structure	Interacts with ATR By similarity. Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP. Ref.1 Ref.6 Ref.9 Ref.12
Subcellular location	Nucleus. Note: Redistributes to discrete nuclear foci upon DNA damage. Ref.1 Ref.9
Tissue specificity	Ubiquitous. Ref.1
Domain	The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage. Ref.7
Post-translational modification	Phosphorylated by ATR. Ref.1
Sequence similarities	Belongs to the ATRIP family.
Caution	The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame.
Sequence caution	The sequence BAB14029.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14029.1 differs from that shown. Reason: Frameshift at position 650. The sequence BAF84257.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage checkpoint Traceable author statement PubMed 14657349. Source: UniProtKB DNA repair Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Traceable author statement. Source: Reactome
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WXE1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WXE1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     661-687: Missing.

Isoform 3 (identifier: Q8WXE1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 791	791	ATR-interacting protein		PRO_0000064740
Regions
	Region	118 – 156	39	Interaction with CINP
	Coiled coil	108 – 217	110	Potential
	Motif	769 – 776	8	EEXXXDL motif
Amino acid modifications
	Modified residue	224	1	Phosphoserine Ref.10 Ref.11 Ref.14
	Modified residue	518	1	Phosphoserine Ref.11 Ref.13 Ref.14 Ref.15
	Cross-link	96		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.8
Natural variations
	Alternative sequence	1 – 93	93	Missing in isoform 3.		VSP_010501
	Alternative sequence	661 – 687	27	Missing in isoform 2.		VSP_010504
	Natural variant	125	1	K → Q. Corresponds to variant rs11925638 [ dbSNP | Ensembl ].		VAR_050683
	Natural variant	240	1	P → L. Corresponds to variant rs35240314 [ dbSNP | Ensembl ].		VAR_050684
Experimental info
	Mutagenesis	769 – 770	2	EE → AA: Abolishes interaction with ATR and its recruitment to sites of DNA damage. Ref.7
	Mutagenesis	774 – 775	2	DD → AA: Abolishes interaction with ATR and its recruitment to sites of DNA damage. Ref.7
	Sequence conflict	280	1	P → L in AAH14153. Ref.4
	Sequence conflict	343	1	T → A in BAF84257. Ref.2
	Sequence conflict	492	1	V → I in BAF84257. Ref.2
	Sequence conflict	683	1	N → D in BAF84257. Ref.2
	Sequence conflict	687	1	V → I in AAH30597. Ref.4
	Sequence conflict	712	1	Q → K in BAF84257. Ref.2
	Sequence conflict	777	1	C → G in BAF84257. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 58981602F7961756	FASTA	791	85,838
	10 20 30 40 50 60 MAGTSAPGSK RRSEPPAPRP GPPPGTGHPP SKRARGFSAA AAPDPDDPFG AHGDFTADDL 70 80 90 100 110 120 EELDTLASQA LSQCPAAARD VSSDHKVHRL LDGMSKNPSG KNRETVPIKD NFELEVLQAQ 130 140 150 160 170 180 YKELKEKMKV MEEEVLIKNG EIKILRDSLH QTESVLEEQR RSHFLLEQEK TQALSDKEKE 190 200 210 220 230 240 FSKKLQSLQS ELQFKDAEMN ELRTKLQTSE RANKLAAPSV SHVSPRKNPS VVIKPEACSP 250 260 270 280 290 300 QFGKTSFPTK ESFSANMSLP HPCQTESGYK PLVGREDSKP HSLRGDSIKQ EEAQKSFVDS 310 320 330 340 350 360 WRQRSNTQGS ILINLLLKQP LIPGSSLSLC HLLSSSSESP AGTPLQPPGF GSTLAGMSGL 370 380 390 400 410 420 RTTGSYDGSF SLSALREAQN LAFTGLNLVA RNECSRDGDP AEGGRRAFPL CQLPGAVHFL 430 440 450 460 470 480 PLVQFFIGLH CQALQDLAAA KRSGAPGDSP THSSCVSSGV ETNPEDSVCI LEGFSVTALS 490 500 510 520 530 540 ILQHLVCHSG AVVSLLLSGV GADSAAGEGN RSLVHRLSDG DMTSALRGVA DDQGQHPLLK 550 560 570 580 590 600 MLLHLLAFSS AATGHLQASV LTQCLKVLVK LAENTSCDFL PRFQCVFQVL PKCLSPETPL 610 620 630 640 650 660 PSVLLAVELL SLLADHDQLA PQLCSHSEGC LLLLLYMYIT SRPDRVALET QWLQLEQEVV 670 680 690 700 710 720 WLLAKLGVQS PLPPVTGSNC QCNVEVVRAL TVMLHRQWLT VRRAGGPPRT DQQRRTVRCL 730 740 750 760 770 780 RDTVLLLHGL SQKDKLFMMH CVEVLHQFDQ VMPGVSMLIR GLPDVTDCEE AALDDLCAAE 790 TDVEDPEVEC G
	Isoform 2 [UniParc]. Checksum: 94E7E31A6BCAAC1D	FASTA	764	83,003
	10 20 30 40 50 60 MAGTSAPGSK RRSEPPAPRP GPPPGTGHPP SKRARGFSAA AAPDPDDPFG AHGDFTADDL 70 80 90 100 110 120 EELDTLASQA LSQCPAAARD VSSDHKVHRL LDGMSKNPSG KNRETVPIKD NFELEVLQAQ 130 140 150 160 170 180 YKELKEKMKV MEEEVLIKNG EIKILRDSLH QTESVLEEQR RSHFLLEQEK TQALSDKEKE 190 200 210 220 230 240 FSKKLQSLQS ELQFKDAEMN ELRTKLQTSE RANKLAAPSV SHVSPRKNPS VVIKPEACSP 250 260 270 280 290 300 QFGKTSFPTK ESFSANMSLP HPCQTESGYK PLVGREDSKP HSLRGDSIKQ EEAQKSFVDS 310 320 330 340 350 360 WRQRSNTQGS ILINLLLKQP LIPGSSLSLC HLLSSSSESP AGTPLQPPGF GSTLAGMSGL 370 380 390 400 410 420 RTTGSYDGSF SLSALREAQN LAFTGLNLVA RNECSRDGDP AEGGRRAFPL CQLPGAVHFL 430 440 450 460 470 480 PLVQFFIGLH CQALQDLAAA KRSGAPGDSP THSSCVSSGV ETNPEDSVCI LEGFSVTALS 490 500 510 520 530 540 ILQHLVCHSG AVVSLLLSGV GADSAAGEGN RSLVHRLSDG DMTSALRGVA DDQGQHPLLK 550 560 570 580 590 600 MLLHLLAFSS AATGHLQASV LTQCLKVLVK LAENTSCDFL PRFQCVFQVL PKCLSPETPL 610 620 630 640 650 660 PSVLLAVELL SLLADHDQLA PQLCSHSEGC LLLLLYMYIT SRPDRVALET QWLQLEQEVV 670 680 690 700 710 720 RALTVMLHRQ WLTVRRAGGP PRTDQQRRTV RCLRDTVLLL HGLSQKDKLF MMHCVEVLHQ 730 740 750 760 FDQVMPGVSM LIRGLPDVTD CEEAALDDLC AAETDVEDPE VECG
	Isoform 3 [UniParc]. Checksum: 417F5811408F2799	FASTA	698	76,336
	10 20 30 40 50 60 MSKNPSGKNR ETVPIKDNFE LEVLQAQYKE LKEKMKVMEE EVLIKNGEIK ILRDSLHQTE 70 80 90 100 110 120 SVLEEQRRSH FLLEQEKTQA LSDKEKEFSK KLQSLQSELQ FKDAEMNELR TKLQTSERAN 130 140 150 160 170 180 KLAAPSVSHV SPRKNPSVVI KPEACSPQFG KTSFPTKESF SANMSLPHPC QTESGYKPLV 190 200 210 220 230 240 GREDSKPHSL RGDSIKQEEA QKSFVDSWRQ RSNTQGSILI NLLLKQPLIP GSSLSLCHLL 250 260 270 280 290 300 SSSSESPAGT PLQPPGFGST LAGMSGLRTT GSYDGSFSLS ALREAQNLAF TGLNLVARNE 310 320 330 340 350 360 CSRDGDPAEG GRRAFPLCQL PGAVHFLPLV QFFIGLHCQA LQDLAAAKRS GAPGDSPTHS 370 380 390 400 410 420 SCVSSGVETN PEDSVCILEG FSVTALSILQ HLVCHSGAVV SLLLSGVGAD SAAGEGNRSL 430 440 450 460 470 480 VHRLSDGDMT SALRGVADDQ GQHPLLKMLL HLLAFSSAAT GHLQASVLTQ CLKVLVKLAE 490 500 510 520 530 540 NTSCDFLPRF QCVFQVLPKC LSPETPLPSV LLAVELLSLL ADHDQLAPQL CSHSEGCLLL 550 560 570 580 590 600 LLYMYITSRP DRVALETQWL QLEQEVVWLL AKLGVQSPLP PVTGSNCQCN VEVVRALTVM 610 620 630 640 650 660 LHRQWLTVRR AGGPPRTDQQ RRTVRCLRDT VLLLHGLSQK DKLFMMHCVE VLHQFDQVMP 670 680 690 GVSMLIRGLP DVTDCEEAAL DDLCAAETDV EDPEVECG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ATR and ATRIP: partners in checkpoint signaling." Cortez D., Guntuku S., Qin J., Elledge S.J. Science 294:1713-1716(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 147-160 AND 722-733, MASS SPECTROMETRY, ALTERNATIVE SPLICING, PHOSPHORYLATION, INTERACTION WITH ATR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Endothelial cell, Fetal brain and Placenta.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Colon, Lymph and Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 134-791 (ISOFORM 1). Tissue: Melanoma.
[6]	"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes." Zou L., Elledge S.J. Science 300:1542-1548(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH THE RPA COMPLEX.
[7]	"Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage." Falck J., Coates J., Jackson S.P. Nature 434:605-611(2005) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAIN, MUTAGENESIS OF 769-GLU-GLU-770 AND 774-ASP-ASP-775.
[8]	"The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells." Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D. J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-96, MASS SPECTROMETRY. Tissue: Lung adenocarcinoma.
[9]	"Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1." Sivasubramaniam S., Sun X., Pan Y.R., Wang S., Lee E.Y. Genes Dev. 22:587-600(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CEP164, SUBCELLULAR LOCATION.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224 AND SER-518, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Functional genomic screens identify CINP as a genome maintenance protein." Lovejoy C.A., Xu X., Bansbach C.E., Glick G.G., Zhao R., Ye F., Sirbu B.M., Titus L.C., Shyr Y., Cortez D. Proc. Natl. Acad. Sci. U.S.A. 106:19304-19309(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CINP.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-518, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224 AND SER-518, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-518, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF451323 mRNA. Translation: AAL38042.1. AK022405 mRNA. Translation: BAB14029.1. Sequence problems. AK291568 mRNA. Translation: BAF84257.1. Different initiation. AK291829 mRNA. Translation: BAF84518.1. AK315075 mRNA. Translation: BAG37544.1. CH471055 Genomic DNA. Translation: EAW64876.1. CH471055 Genomic DNA. Translation: EAW64878.1. BC014153 mRNA. Translation: AAH14153.2. BC020563 mRNA. Translation: AAH20563.1. BC030597 mRNA. Translation: AAH30597.1. AL832917 mRNA. Translation: CAH10621.1.
IPI	IPI00102918. IPI00103517. IPI00413576.
RefSeq	NP_001257951.1. NM_001271022.1. NP_001257952.1. NM_001271023.1. NP_115542.2. NM_032166.3. NP_569055.1. NM_130384.2.
UniGene	Hs.694840.
3D structure databases
ProteinModelPortal	Q8WXE1.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-46495N.
IntAct	Q8WXE1. 3 interactions.
MINT	MINT-5009350.
PTM databases
PhosphoSite	Q8WXE1.
Polymorphism databases
DMDM	48428109.
Proteomic databases
PaxDb	Q8WXE1.
PRIDE	Q8WXE1.
Protocols and materials databases
DNASU	84126.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320211; ENSP00000323099; ENSG00000164053. ENST00000346691; ENSP00000302338; ENSG00000164053. ENST00000412052; ENSP00000400930; ENSG00000164053.
GeneID	84126.
KEGG	hsa:84126.
UCSC	uc003ctf.1. human. uc003ctg.1. human.
Organism-specific databases
CTD	84126.
GeneCards	GC03P048488.
HGNC	HGNC:33499. ATRIP.
HPA	CAB033109.
MIM	606605. gene.
neXtProt	NX_Q8WXE1.
PharmGKB	PA162377290.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG87267.
HOVERGEN	HBG050618.
InParanoid	Q8WXE1.
KO	K10905.
OMA	TGSNCQC.
OrthoDB	EOG43BMNC.
PhylomeDB	Q8WXE1.
Enzyme and pathway databases
Reactome	REACT_115566. Cell Cycle.
Gene expression databases
ArrayExpress	Q8WXE1.
Bgee	Q8WXE1.
CleanEx	HS_ATRIP.
Genevestigator	Q8WXE1.
GermOnline	ENSG00000164053. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	84126.
NextBio	73397.
SOURCE	Search...

Entry information

Entry name

ATRIP_HUMAN

Accession

Primary (citable) accession number: Q8WXE1
Secondary accession number(s): A8K6A3 , A8K714, B2RCE7, Q69YK9, Q8NHQ2, Q8WUG7, Q96CL3, Q9HA30

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	March 1, 2002
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.