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Protein

Caskin-2

Gene

CASKIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Caskin-2
Alternative name(s):
CASK-interacting protein 2
Gene namesi
Name:CASKIN2
Synonyms:KIAA1139
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18200. CASKIN2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177303.
PharmGKBiPA134944093.

Polymorphism and mutation databases

DMDMi296434467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669831 – 1202Caskin-2Add BLAST1202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphotyrosineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei409PhosphoserineBy similarity1
Modified residuei471PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei858PhosphoserineCombined sources1
Modified residuei877PhosphoserineBy similarity1
Modified residuei878PhosphoserineCombined sources1
Modified residuei892PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WXE0.
MaxQBiQ8WXE0.
PaxDbiQ8WXE0.
PeptideAtlasiQ8WXE0.
PRIDEiQ8WXE0.

PTM databases

iPTMnetiQ8WXE0.
PhosphoSitePlusiQ8WXE0.
SwissPalmiQ8WXE0.

Expressioni

Gene expression databases

BgeeiENSG00000177303.
CleanExiHS_CASKIN2.
ExpressionAtlasiQ8WXE0. baseline and differential.
GenevisibleiQ8WXE0. HS.

Organism-specific databases

HPAiHPA055836.

Interactioni

Subunit structurei

May not bind CASK.

Protein-protein interaction databases

BioGridi121577. 4 interactors.
IntActiQ8WXE0. 3 interactors.
MINTiMINT-6768531.
STRINGi9606.ENSP00000325355.

Structurei

Secondary structure

11202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi284 – 290Combined sources7
Beta strandi308 – 312Combined sources5
Beta strandi320 – 324Combined sources5
Beta strandi335 – 337Combined sources3
Helixi339 – 341Combined sources3
Beta strandi342 – 345Combined sources4
Helixi490 – 499Combined sources10
Turni500 – 502Combined sources3
Helixi507 – 512Combined sources6
Helixi517 – 520Combined sources4
Helixi525 – 530Combined sources6
Helixi536 – 547Combined sources12
Turni555 – 558Combined sources4
Helixi563 – 569Combined sources7
Helixi573 – 575Combined sources3
Helixi576 – 581Combined sources6
Helixi587 – 590Combined sources4
Helixi595 – 597Combined sources3
Helixi598 – 601Combined sources4
Helixi606 – 624Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KE9NMR-A284-348[»]
4IS7X-ray2.75A483-633[»]
5L1MX-ray2.75A483-633[»]
ProteinModelPortaliQ8WXE0.
SMRiQ8WXE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 77ANK 1Add BLAST30
Repeati81 – 110ANK 2Add BLAST30
Repeati114 – 143ANK 3Add BLAST30
Repeati147 – 176ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 249ANK 6Add BLAST30
Domaini281 – 347SH3PROSITE-ProRule annotationAdd BLAST67
Domaini489 – 552SAM 1PROSITE-ProRule annotationAdd BLAST64
Domaini558 – 622SAM 2PROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi685 – 1133Pro-richAdd BLAST449

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 2 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
KOG4384. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8WXE0.
OMAiPYVFMYP.
OrthoDBiEOG091G00P3.
PhylomeDBiQ8WXE0.
TreeFamiTF320582.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGREQDLILA VKNGDVTGVQ KLVAKVKATK TKLLGSTKRL NVNYQDADGF
60 70 80 90 100
SALHHAALGG SLELIALLLE AQATVDIKDS NGMRPLHYAA WQGRLEPVRL
110 120 130 140 150
LLRASAAVNA ASLDGQIPLH LAAQYGHYEV SEMLLQHQSN PCLVNKAKKT
160 170 180 190 200
PLDLACEFGR LKVAQLLLNS HLCVALLEGE AKDPCDPNYT TPLHLAAKNG
210 220 230 240 250
HREVIRQLLR AGIEINRQTK TGTALHEAAL YGKTEVVRLL LEGGVDVNIR
260 270 280 290 300
NTYNQTALDI VNQFTTSQAS REIKQLLREA SGILKVRALK DFWNLHDPTA
310 320 330 340 350
LNVRAGDVIT VLEQHPDGRW KGHIHESQRG TDRIGYFPPG IVEVVSKRVG
360 370 380 390 400
IPAARLPSAP TPLRPGFSRT PQPPAEEPPH PLTYSQLPRV GLSPDSPAGD
410 420 430 440 450
RNSVGSEGSV GSIRSAGSGQ SSEGTNGHGP GLLIENAQPL PSAGEDQVLP
460 470 480 490 500
GLHPPSLADN LSHRPLANCR SGEQIFTQDV RPEQLLEGKD AQAIHNWLSE
510 520 530 540 550
FQLEGYTAHF LQAGYDVPTI SRMTPEDLTA IGVTKPGHRK KIASEIAQLS
560 570 580 590 600
IAEWLPSYIP TDLLEWLCAL GLPQYHKQLV SSGYDSMGLV ADLTWEELQE
610 620 630 640 650
IGVNKLGHQK KLMLGVKRLA ELRRGLLQGE ALSEGGRRLA KGPELMAIEG
660 670 680 690 700
LENGEGPATA GPRLLTFQGS ELSPELQAAM AGGGPEPLPL PPARSPSQES
710 720 730 740 750
IGARSRGSGH SQEQPAPQPS GGDPSPPQER NLPEGTERPP KLCSSLPGQG
760 770 780 790 800
PPPYVFMYPQ GSPSSPAPGP PPGAPWAFSY LAGPPATPPD PPRPKRRSHS
810 820 830 840 850
LSRPGPTEGD AEGEAEGPVG STLGSYATLT RRPGRSALVR TSPSVTPTPA
860 870 880 890 900
RGTPRSQSFA LRARRKGPPP PPPKRLSSVS GPSPEPPPLD ESPGPKEGAT
910 920 930 940 950
GPRRRTLSEP AGPSEPPGPP APAGPASDTE EEEPGPEGTP PSRGSSGEGL
960 970 980 990 1000
PFAEEGNLTI KQRPKPAGPP PRETPVPPGL DFNLTESDTV KRRPKCRERE
1010 1020 1030 1040 1050
PLQTALLAFG VASATPGPAA PLPSPTPGES PPASSLPQPE PSSLPAQGVP
1060 1070 1080 1090 1100
TPLAPSPAMQ PPVPPCPGPG LESSAASRWN GETEPPAAPA ALLKVPGAGT
1110 1120 1130 1140 1150
APKPVSVACT QLAFSGPKLA PRLGPRPVPP PRPESTGTVG PGQAQQRLEQ
1160 1170 1180 1190 1200
TSSSLAAALR AAEKSIGTKE QEGTPSASTK HILDDISTMF DALADQLDAM

LD
Length:1,202
Mass (Da):126,783
Last modified:May 18, 2010 - v2
Checksum:i881E6BAEEBDF3DC5
GO
Isoform 2 (identifier: Q8WXE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:1,120
Mass (Da):118,157
Checksum:iF120B5C26DAD308B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti640A → G in BAH14307 (PubMed:14702039).Curated1
Sequence conflicti1093L → P in BAH14307 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060244891E → G.Combined sources4 PublicationsCorresponds to variant rs7503373dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0405681 – 82Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451976 mRNA. Translation: AAL49757.1.
AK300354 mRNA. Translation: BAG62095.1.
AK315936 mRNA. Translation: BAH14307.1.
AC100787 Genomic DNA. No translation available.
BC066643 mRNA. Translation: AAH66643.1.
AB032965 mRNA. Translation: BAA86453.1.
CCDSiCCDS11723.1. [Q8WXE0-1]
CCDS45775.1. [Q8WXE0-2]
RefSeqiNP_001136115.1. NM_001142643.2. [Q8WXE0-2]
NP_065804.2. NM_020753.4. [Q8WXE0-1]
UniGeneiHs.274408.
Hs.745460.

Genome annotation databases

EnsembliENST00000321617; ENSP00000325355; ENSG00000177303. [Q8WXE0-1]
ENST00000433559; ENSP00000406963; ENSG00000177303. [Q8WXE0-2]
GeneIDi57513.
KEGGihsa:57513.
UCSCiuc002joc.5. human. [Q8WXE0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451976 mRNA. Translation: AAL49757.1.
AK300354 mRNA. Translation: BAG62095.1.
AK315936 mRNA. Translation: BAH14307.1.
AC100787 Genomic DNA. No translation available.
BC066643 mRNA. Translation: AAH66643.1.
AB032965 mRNA. Translation: BAA86453.1.
CCDSiCCDS11723.1. [Q8WXE0-1]
CCDS45775.1. [Q8WXE0-2]
RefSeqiNP_001136115.1. NM_001142643.2. [Q8WXE0-2]
NP_065804.2. NM_020753.4. [Q8WXE0-1]
UniGeneiHs.274408.
Hs.745460.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KE9NMR-A284-348[»]
4IS7X-ray2.75A483-633[»]
5L1MX-ray2.75A483-633[»]
ProteinModelPortaliQ8WXE0.
SMRiQ8WXE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121577. 4 interactors.
IntActiQ8WXE0. 3 interactors.
MINTiMINT-6768531.
STRINGi9606.ENSP00000325355.

PTM databases

iPTMnetiQ8WXE0.
PhosphoSitePlusiQ8WXE0.
SwissPalmiQ8WXE0.

Polymorphism and mutation databases

DMDMi296434467.

Proteomic databases

EPDiQ8WXE0.
MaxQBiQ8WXE0.
PaxDbiQ8WXE0.
PeptideAtlasiQ8WXE0.
PRIDEiQ8WXE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321617; ENSP00000325355; ENSG00000177303. [Q8WXE0-1]
ENST00000433559; ENSP00000406963; ENSG00000177303. [Q8WXE0-2]
GeneIDi57513.
KEGGihsa:57513.
UCSCiuc002joc.5. human. [Q8WXE0-1]

Organism-specific databases

CTDi57513.
GeneCardsiCASKIN2.
H-InvDBHIX0020291.
HGNCiHGNC:18200. CASKIN2.
HPAiHPA055836.
MIMi612185. gene.
neXtProtiNX_Q8WXE0.
OpenTargetsiENSG00000177303.
PharmGKBiPA134944093.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
KOG4384. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8WXE0.
OMAiPYVFMYP.
OrthoDBiEOG091G00P3.
PhylomeDBiQ8WXE0.
TreeFamiTF320582.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177303-MONOMER.

Miscellaneous databases

GenomeRNAii57513.
PROiQ8WXE0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177303.
CleanExiHS_CASKIN2.
ExpressionAtlasiQ8WXE0. baseline and differential.
GenevisibleiQ8WXE0. HS.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSKI2_HUMAN
AccessioniPrimary (citable) accession number: Q8WXE0
Secondary accession number(s): B4DTT3
, B7Z9H1, Q7LG69, Q9ULT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.