Caskin-1 - Homo sapiens (Human)

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Q8WXD9 (CSKI1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Caskin-1

Alternative name(s):
CASK-interacting protein 1

Gene names

Name:	CASKIN1
Synonyms:	KIAA1306

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1431 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May link the scaffolding protein CASK to downstream intracellular effectors By similarity.
Subunit structure	Binds the CaM kinase domain of CASK. Forms a ternary complex with CASK and LIN7A, LIN7B or LIN7C. Competes with APBA1 that forms a similar complex with CASK and LIN7 proteins. The tripartite complex CASKIN1/CASK/LIN7(A/B/C) binds the cytoplasmic tail of NRXN1 By similarity. Polymerizes, via the tandem SAM domains, to form long, 8 nM wide fibers, upon which other proteins can assemble. Ref.3
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 6 ANK repeats. Contains 2 SAM (sterile alpha motif) domains. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	ANK repeat Repeat SH3 domain
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Inferred from sequence or structural similarity Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Inferred from sequence or structural similarity Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1431

1431

Caskin-1

PRO_0000066980

Regions

Repeat

48 – 77

ANK 1

Repeat

81 – 110

ANK 2

Repeat

114 – 143

ANK 3

Repeat

147 – 176

ANK 4

Repeat

188 – 217

ANK 5

Repeat

220 – 249

ANK 6

Domain

281 – 347

SH3

Domain

472 – 535

SAM 1

Domain

541 – 605

SAM 2

Region

375 – 469

CASK-binding By similarity

Compositional bias

714 – 1365

652

Pro-rich

Amino acid modifications

Modified residue

253

Phosphotyrosine By similarity

Modified residue

646

Phosphoserine By similarity

Modified residue

775

Phosphothreonine By similarity

Modified residue

787

Phosphoserine By similarity

Modified residue

1065

Phosphothreonine By similarity

Modified residue

1067

Phosphoserine By similarity

Modified residue

1257

Phosphoserine By similarity

Modified residue

1364

Phosphoserine By similarity

Experimental info

Sequence conflict

278

R → P in BAA92544. Ref.2

Secondary structure

1431

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q8WXD9 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: CDF60E68B81E884A
Show »

FASTA

1,431

149,814

        10         20         30         40         50         60 
MGKEQELVQA VKAEDVGTAQ RLLQRPRPGK AKLLGSTKKI NVNFQDPDGF SALHHAALNG 

        70         80         90        100        110        120 
NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL VLKAGSAVNI PSDEGHIPLH 

       130        140        150        160        170        180 
LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT PLDLACEFGR VGVVQLLLSS NMCAALLEPR 

       190        200        210        220        230        240 
PGDATDPNGT SPLHLAAKNG HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL 

       250        260        270        280        290        300 
LDSGINAHVR NTYSQTALDI VHQFTTSQAS REIKQLLREA SAALQVRATK DYCNNYDLTS 

       310        320        330        340        350        360 
LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG SRAGTEPSLP 

       370        380        390        400        410        420 
QGSSSSGPSA PPEEIWVLRK PFAGGDRSGS ISGMAGGRGS GGHALHAGSE GVKLLATVLS 

       430        440        450        460        470        480 
QKSVSESGPG DSPAKPPEGS AGVARSQPPV AHAGQVYGEQ PPKKLEPASE GKSSEAVSQW 

       490        500        510        520        530        540 
LTAFQLQLYA PNFISAGYDL PTISRMTPED LTAIGVTKPG HRKKIAAEIS GLSIPDWLPE 

       550        560        570        580        590        600 
HKPANLAVWL SMIGLAQYYK VLVDNGYENI DFITDITWED LQEIGITKLG HQKKLMLAVR 

       610        620        630        640        650        660 
KLAELQKAEY AKYEGGPLRR KAPQSLEVMA IESPPPPEPT PADCQSPKMT TFQDSELSDE 

       670        680        690        700        710        720 
LQAAMTGPAE VGPTTEKPSS HLPPTPRATT RQDSSLGGRA RHMSSSQELL GDGPPGPSSP 

       730        740        750        760        770        780 
MSRSQEYLLD EGPAPGTPPR EARPGRHGHS IKRASVPPVP GKPRQVLPPG TSHFTPPQTP 

       790        800        810        820        830        840 
TKTRPGSPQA LGGPHGPAPA TAKVKPTPQL LPPTERPMSP RSLPQSPTHR GFAYVLPQPV 

       850        860        870        880        890        900 
EGEVGPAAPG PAPPPVPTAV PTLCLPPEAD AEPGRPKKRA HSLNRYAASD SEPERDELLV 

       910        920        930        940        950        960 
PAAAGPYATV QRRVGRSHSV RAPAGADKNV NRSQSFAVRP RKKGPPPPPP KRSSSALASA 

       970        980        990       1000       1010       1020 
NLADEPVPDA EPEDGLLGVR AQCRRASDLA GSVDTGSAGS VKSIAAMLEL SSIGGGGRAA 

      1030       1040       1050       1060       1070       1080 
RRPPEGHPTP RPASPEPGRV ATVLASVKHK EAIGPGGEVV NRRRTLSGPV TGLLATARRG 

      1090       1100       1110       1120       1130       1140 
PGESADPGPF VEDGTGRQRP RGPSKGEAGV EGPPLAKVEA SATLKRRIRA KQNQQENVKF 

      1150       1160       1170       1180       1190       1200 
ILTESDTVKR RPKAKEREAG PEPPPPLSVY HNGTGTVRRR PASEQAGPPE LPPPPPPAEP 

      1210       1220       1230       1240       1250       1260 
PPTDLAHLPP LPPPEGEARK PAKPPVSPKP VLTQPVPKLQ GSPTPTSKKV PLPGPGSPEV 

      1270       1280       1290       1300       1310       1320 
KRAHGTPPPV SPKPPPPPTA PKPVKAVAGL PSGSAGPSPA PSPARQPPAA LAKPPGTPPS 

      1330       1340       1350       1360       1370       1380 
LGASPAKPPS PGAPALHVPA KPPRAAAAAA AAAAAPPAPP EGASPGDSAR QKLEETSACL 

      1390       1400       1410       1420       1430 
AAALQAVEEK IRQEDAQGPR DSAAEKSTGS ILDDIGSMFD DLADQLDAML E

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with Caskin 1, a novel CASK-binding protein." Tabuchi K., Biederer T., Butz S., Suedhof T.C. J. Neurosci. 22:4264-4273(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 278-1431. Tissue: Brain.
[3]	"Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK." Stafford R.L., Hinde E., Knight M.J., Pennella M.A., Ear J., Digman M.A., Gratton E., Bowie J.U. Structure 19:1826-1836(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 470-605, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF451977 mRNA. Translation: AAL49758.1.
AB037727 mRNA. Translation: BAA92544.1.

IPI

IPI00385480.

RefSeq

NP_065815.1. NM_020764.3.

UniGene

Hs.643537.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3SEI	X-ray	2.40	A/B	470-605	[»]
3SEN	X-ray	3.10	A/B/C/D	470-613	[»]

ProteinModelPortal

Q8WXD9.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-34890N.

STRING

9606.ENSP00000345436.

PTM databases

PhosphoSite

Q8WXD9.

Polymorphism databases

DMDM

61213003.

Proteomic databases

PaxDb

Q8WXD9.

PRIDE

Q8WXD9.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000343516; ENSP00000345436; ENSG00000167971.

GeneID

57524.

KEGG

hsa:57524.

UCSC

uc010bsg.1. human.

Organism-specific databases

CTD

57524.

GeneCards

GC16M002227.

HGNC

HGNC:20879. CASKIN1.

HPA

HPA055990.

MIM

612184. gene.

neXtProt

NX_Q8WXD9.

PharmGKB

PA134878267.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0666.

HOGENOM

HOG000049168.

HOVERGEN

HBG051133.

InParanoid

Q8WXD9.

OMA

RAKQNQQ.

Gene expression databases

ArrayExpress

Q8WXD9.

Bgee

Q8WXD9.

CleanEx

HS_CASKIN1.

Genevestigator

Q8WXD9.

GermOnline

ENSG00000167971. Homo sapiens.

Family and domain databases

Gene3D

1.10.150.50. 2 hits.
1.25.40.20. 1 hit.

InterPro

IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027013. Caskin.
IPR027001. Caskin/Ankyrin_rpt_con_pro.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]

PANTHER

PTHR24177. PTHR24177. 1 hit.
PTHR24177:SF0. PTHR24177:SF0. 1 hit.

Pfam

PF12796. Ank_2. 2 hits.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]

PRINTS

PR01415. ANKYRIN.

SMART

SM00248. ANK. 6 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF48403. ANK. 1 hit.
SSF47769. SAM_homology. 2 hits.
SSF50044. SH3. 1 hit.

PROSITE

PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

57524.

NextBio

63914.

SOURCE

Search...

Entry information

Entry name

CSKI1_HUMAN

Accession

Primary (citable) accession number: Q8WXD9
Secondary accession number(s): Q9P2P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents