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Protein

Caskin-1

Gene

CASKIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May link the scaffolding protein CASK to downstream intracellular effectors.By similarity

GO - Biological processi

  1. signal transduction Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Caskin-1
Alternative name(s):
CASK-interacting protein 1
Gene namesi
Name:CASKIN1
Synonyms:KIAA1306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:20879. CASKIN1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878267.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14311431Caskin-1PRO_0000066980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei253 – 2531PhosphotyrosineBy similarity
Modified residuei1257 – 12571PhosphoserineBy similarity
Modified residuei1364 – 13641PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WXD9.
PaxDbiQ8WXD9.
PRIDEiQ8WXD9.

PTM databases

PhosphoSiteiQ8WXD9.

Expressioni

Gene expression databases

BgeeiQ8WXD9.
CleanExiHS_CASKIN1.
ExpressionAtlasiQ8WXD9. baseline and differential.
GenevestigatoriQ8WXD9.

Organism-specific databases

HPAiHPA055990.

Interactioni

Subunit structurei

Binds the CaM kinase domain of CASK. Forms a ternary complex with CASK and LIN7A, LIN7B or LIN7C. Competes with APBA1 that forms a similar complex with CASK and LIN7 proteins. The tripartite complex CASKIN1/CASK/LIN7(A/B/C) binds the cytoplasmic tail of NRXN1 (By similarity). Polymerizes, via the tandem SAM domains, to form long, 8 nM wide fibers, upon which other proteins can assemble.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CASKO149364EBI-970261,EBI-1215506

Protein-protein interaction databases

BioGridi121585. 1 interaction.
DIPiDIP-34890N.
IntActiQ8WXD9. 1 interaction.
STRINGi9606.ENSP00000345436.

Structurei

Secondary structure

1
1431
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi470 – 48213Combined sources
Turni483 – 4853Combined sources
Helixi487 – 4893Combined sources
Helixi490 – 4956Combined sources
Helixi500 – 5034Combined sources
Helixi508 – 5136Combined sources
Helixi519 – 53012Combined sources
Helixi546 – 5527Combined sources
Helixi556 – 5583Combined sources
Helixi559 – 5646Combined sources
Helixi570 – 5734Combined sources
Helixi578 – 5847Combined sources
Helixi589 – 60517Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SEIX-ray2.40A/B470-605[»]
3SENX-ray3.10A/B/C/D470-613[»]
ProteinModelPortaliQ8WXD9.
SMRiQ8WXD9. Positions 19-348, 472-613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati48 – 7730ANK 1Add
BLAST
Repeati81 – 11030ANK 2Add
BLAST
Repeati114 – 14330ANK 3Add
BLAST
Repeati147 – 17630ANK 4Add
BLAST
Repeati188 – 21730ANK 5Add
BLAST
Repeati220 – 24930ANK 6Add
BLAST
Domaini281 – 34767SH3PROSITE-ProRule annotationAdd
BLAST
Domaini472 – 53564SAM 1PROSITE-ProRule annotationAdd
BLAST
Domaini541 – 60565SAM 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni375 – 46995CASK-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi714 – 1365652Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 2 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8WXD9.
OMAiPKIQGSP.
OrthoDBiEOG7V49XK.
PhylomeDBiQ8WXD9.
TreeFamiTF320582.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027013. Caskin-1.
IPR027001. Caskin/Ankyrin_rpt_con_pro.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR24177. PTHR24177. 1 hit.
PTHR24177:SF12. PTHR24177:SF12. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKEQELVQA VKAEDVGTAQ RLLQRPRPGK AKLLGSTKKI NVNFQDPDGF
60 70 80 90 100
SALHHAALNG NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL
110 120 130 140 150
VLKAGSAVNI PSDEGHIPLH LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT
160 170 180 190 200
PLDLACEFGR VGVVQLLLSS NMCAALLEPR PGDATDPNGT SPLHLAAKNG
210 220 230 240 250
HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL LDSGINAHVR
260 270 280 290 300
NTYSQTALDI VHQFTTSQAS REIKQLLREA SAALQVRATK DYCNNYDLTS
310 320 330 340 350
LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG
360 370 380 390 400
SRAGTEPSLP QGSSSSGPSA PPEEIWVLRK PFAGGDRSGS ISGMAGGRGS
410 420 430 440 450
GGHALHAGSE GVKLLATVLS QKSVSESGPG DSPAKPPEGS AGVARSQPPV
460 470 480 490 500
AHAGQVYGEQ PPKKLEPASE GKSSEAVSQW LTAFQLQLYA PNFISAGYDL
510 520 530 540 550
PTISRMTPED LTAIGVTKPG HRKKIAAEIS GLSIPDWLPE HKPANLAVWL
560 570 580 590 600
SMIGLAQYYK VLVDNGYENI DFITDITWED LQEIGITKLG HQKKLMLAVR
610 620 630 640 650
KLAELQKAEY AKYEGGPLRR KAPQSLEVMA IESPPPPEPT PADCQSPKMT
660 670 680 690 700
TFQDSELSDE LQAAMTGPAE VGPTTEKPSS HLPPTPRATT RQDSSLGGRA
710 720 730 740 750
RHMSSSQELL GDGPPGPSSP MSRSQEYLLD EGPAPGTPPR EARPGRHGHS
760 770 780 790 800
IKRASVPPVP GKPRQVLPPG TSHFTPPQTP TKTRPGSPQA LGGPHGPAPA
810 820 830 840 850
TAKVKPTPQL LPPTERPMSP RSLPQSPTHR GFAYVLPQPV EGEVGPAAPG
860 870 880 890 900
PAPPPVPTAV PTLCLPPEAD AEPGRPKKRA HSLNRYAASD SEPERDELLV
910 920 930 940 950
PAAAGPYATV QRRVGRSHSV RAPAGADKNV NRSQSFAVRP RKKGPPPPPP
960 970 980 990 1000
KRSSSALASA NLADEPVPDA EPEDGLLGVR AQCRRASDLA GSVDTGSAGS
1010 1020 1030 1040 1050
VKSIAAMLEL SSIGGGGRAA RRPPEGHPTP RPASPEPGRV ATVLASVKHK
1060 1070 1080 1090 1100
EAIGPGGEVV NRRRTLSGPV TGLLATARRG PGESADPGPF VEDGTGRQRP
1110 1120 1130 1140 1150
RGPSKGEAGV EGPPLAKVEA SATLKRRIRA KQNQQENVKF ILTESDTVKR
1160 1170 1180 1190 1200
RPKAKEREAG PEPPPPLSVY HNGTGTVRRR PASEQAGPPE LPPPPPPAEP
1210 1220 1230 1240 1250
PPTDLAHLPP LPPPEGEARK PAKPPVSPKP VLTQPVPKLQ GSPTPTSKKV
1260 1270 1280 1290 1300
PLPGPGSPEV KRAHGTPPPV SPKPPPPPTA PKPVKAVAGL PSGSAGPSPA
1310 1320 1330 1340 1350
PSPARQPPAA LAKPPGTPPS LGASPAKPPS PGAPALHVPA KPPRAAAAAA
1360 1370 1380 1390 1400
AAAAAPPAPP EGASPGDSAR QKLEETSACL AAALQAVEEK IRQEDAQGPR
1410 1420 1430
DSAAEKSTGS ILDDIGSMFD DLADQLDAML E
Length:1,431
Mass (Da):149,814
Last modified:March 1, 2002 - v1
Checksum:iCDF60E68B81E884A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti278 – 2781R → P in BAA92544. (PubMed:10718198)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451977 mRNA. Translation: AAL49758.1.
AB037727 mRNA. Translation: BAA92544.1.
CCDSiCCDS42103.1.
RefSeqiNP_065815.1. NM_020764.3.
UniGeneiHs.643537.

Genome annotation databases

EnsembliENST00000343516; ENSP00000345436; ENSG00000167971.
GeneIDi57524.
KEGGihsa:57524.
UCSCiuc010bsg.1. human.

Polymorphism databases

DMDMi61213003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451977 mRNA. Translation: AAL49758.1.
AB037727 mRNA. Translation: BAA92544.1.
CCDSiCCDS42103.1.
RefSeqiNP_065815.1. NM_020764.3.
UniGeneiHs.643537.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SEIX-ray2.40A/B470-605[»]
3SENX-ray3.10A/B/C/D470-613[»]
ProteinModelPortaliQ8WXD9.
SMRiQ8WXD9. Positions 19-348, 472-613.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121585. 1 interaction.
DIPiDIP-34890N.
IntActiQ8WXD9. 1 interaction.
STRINGi9606.ENSP00000345436.

PTM databases

PhosphoSiteiQ8WXD9.

Polymorphism databases

DMDMi61213003.

Proteomic databases

MaxQBiQ8WXD9.
PaxDbiQ8WXD9.
PRIDEiQ8WXD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343516; ENSP00000345436; ENSG00000167971.
GeneIDi57524.
KEGGihsa:57524.
UCSCiuc010bsg.1. human.

Organism-specific databases

CTDi57524.
GeneCardsiGC16M002227.
HGNCiHGNC:20879. CASKIN1.
HPAiHPA055990.
MIMi612184. gene.
neXtProtiNX_Q8WXD9.
PharmGKBiPA134878267.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8WXD9.
OMAiPKIQGSP.
OrthoDBiEOG7V49XK.
PhylomeDBiQ8WXD9.
TreeFamiTF320582.

Miscellaneous databases

ChiTaRSiCASKIN1. human.
GenomeRNAii57524.
NextBioi63914.
PROiQ8WXD9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WXD9.
CleanExiHS_CASKIN1.
ExpressionAtlasiQ8WXD9. baseline and differential.
GenevestigatoriQ8WXD9.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027013. Caskin-1.
IPR027001. Caskin/Ankyrin_rpt_con_pro.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR24177. PTHR24177. 1 hit.
PTHR24177:SF12. PTHR24177:SF12. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with Caskin 1, a novel CASK-binding protein."
    Tabuchi K., Biederer T., Butz S., Suedhof T.C.
    J. Neurosci. 22:4264-4273(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 278-1431.
    Tissue: Brain.
  3. "Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK."
    Stafford R.L., Hinde E., Knight M.J., Pennella M.A., Ear J., Digman M.A., Gratton E., Bowie J.U.
    Structure 19:1826-1836(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 470-605, SUBUNIT.

Entry informationi

Entry nameiCSKI1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXD9
Secondary accession number(s): Q9P2P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.