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Q8WXD9

- CSKI1_HUMAN

UniProt

Q8WXD9 - CSKI1_HUMAN

Protein

Caskin-1

Gene

CASKIN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May link the scaffolding protein CASK to downstream intracellular effectors.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. signal transduction Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caskin-1
    Alternative name(s):
    CASK-interacting protein 1
    Gene namesi
    Name:CASKIN1
    Synonyms:KIAA1306
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:20879. CASKIN1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134878267.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14311431Caskin-1PRO_0000066980Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei253 – 2531PhosphotyrosineBy similarity
    Modified residuei1257 – 12571PhosphoserineBy similarity
    Modified residuei1364 – 13641PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WXD9.
    PaxDbiQ8WXD9.
    PRIDEiQ8WXD9.

    PTM databases

    PhosphoSiteiQ8WXD9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WXD9.
    BgeeiQ8WXD9.
    CleanExiHS_CASKIN1.
    GenevestigatoriQ8WXD9.

    Organism-specific databases

    HPAiHPA055990.

    Interactioni

    Subunit structurei

    Binds the CaM kinase domain of CASK. Forms a ternary complex with CASK and LIN7A, LIN7B or LIN7C. Competes with APBA1 that forms a similar complex with CASK and LIN7 proteins. The tripartite complex CASKIN1/CASK/LIN7(A/B/C) binds the cytoplasmic tail of NRXN1 By similarity. Polymerizes, via the tandem SAM domains, to form long, 8 nM wide fibers, upon which other proteins can assemble.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CASKO149364EBI-970261,EBI-1215506

    Protein-protein interaction databases

    BioGridi121585. 1 interaction.
    DIPiDIP-34890N.
    IntActiQ8WXD9. 1 interaction.
    STRINGi9606.ENSP00000345436.

    Structurei

    Secondary structure

    1
    1431
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi470 – 48213
    Turni483 – 4853
    Helixi487 – 4893
    Helixi490 – 4956
    Helixi500 – 5034
    Helixi508 – 5136
    Helixi519 – 53012
    Helixi546 – 5527
    Helixi556 – 5583
    Helixi559 – 5646
    Helixi570 – 5734
    Helixi578 – 5847
    Helixi589 – 60517

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3SEIX-ray2.40A/B470-605[»]
    3SENX-ray3.10A/B/C/D470-613[»]
    ProteinModelPortaliQ8WXD9.
    SMRiQ8WXD9. Positions 19-348, 472-613.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati48 – 7730ANK 1Add
    BLAST
    Repeati81 – 11030ANK 2Add
    BLAST
    Repeati114 – 14330ANK 3Add
    BLAST
    Repeati147 – 17630ANK 4Add
    BLAST
    Repeati188 – 21730ANK 5Add
    BLAST
    Repeati220 – 24930ANK 6Add
    BLAST
    Domaini281 – 34767SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini472 – 53564SAM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini541 – 60565SAM 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni375 – 46995CASK-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi714 – 1365652Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 6 ANK repeats.PROSITE-ProRule annotation
    Contains 2 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000049168.
    HOVERGENiHBG051133.
    InParanoidiQ8WXD9.
    OMAiPKIQGSP.
    OrthoDBiEOG7V49XK.
    PhylomeDBiQ8WXD9.
    TreeFamiTF320582.

    Family and domain databases

    Gene3Di1.10.150.50. 2 hits.
    1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR027013. Caskin-1.
    IPR027001. Caskin/Ankyrin_rpt_con_pro.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR24177. PTHR24177. 1 hit.
    PTHR24177:SF12. PTHR24177:SF12. 1 hit.
    PfamiPF12796. Ank_2. 2 hits.
    PF00536. SAM_1. 2 hits.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 6 hits.
    SM00454. SAM. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 2 hits.
    SSF48403. SSF48403. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 6 hits.
    PS50105. SAM_DOMAIN. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WXD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKEQELVQA VKAEDVGTAQ RLLQRPRPGK AKLLGSTKKI NVNFQDPDGF     50
    SALHHAALNG NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL 100
    VLKAGSAVNI PSDEGHIPLH LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT 150
    PLDLACEFGR VGVVQLLLSS NMCAALLEPR PGDATDPNGT SPLHLAAKNG 200
    HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL LDSGINAHVR 250
    NTYSQTALDI VHQFTTSQAS REIKQLLREA SAALQVRATK DYCNNYDLTS 300
    LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG 350
    SRAGTEPSLP QGSSSSGPSA PPEEIWVLRK PFAGGDRSGS ISGMAGGRGS 400
    GGHALHAGSE GVKLLATVLS QKSVSESGPG DSPAKPPEGS AGVARSQPPV 450
    AHAGQVYGEQ PPKKLEPASE GKSSEAVSQW LTAFQLQLYA PNFISAGYDL 500
    PTISRMTPED LTAIGVTKPG HRKKIAAEIS GLSIPDWLPE HKPANLAVWL 550
    SMIGLAQYYK VLVDNGYENI DFITDITWED LQEIGITKLG HQKKLMLAVR 600
    KLAELQKAEY AKYEGGPLRR KAPQSLEVMA IESPPPPEPT PADCQSPKMT 650
    TFQDSELSDE LQAAMTGPAE VGPTTEKPSS HLPPTPRATT RQDSSLGGRA 700
    RHMSSSQELL GDGPPGPSSP MSRSQEYLLD EGPAPGTPPR EARPGRHGHS 750
    IKRASVPPVP GKPRQVLPPG TSHFTPPQTP TKTRPGSPQA LGGPHGPAPA 800
    TAKVKPTPQL LPPTERPMSP RSLPQSPTHR GFAYVLPQPV EGEVGPAAPG 850
    PAPPPVPTAV PTLCLPPEAD AEPGRPKKRA HSLNRYAASD SEPERDELLV 900
    PAAAGPYATV QRRVGRSHSV RAPAGADKNV NRSQSFAVRP RKKGPPPPPP 950
    KRSSSALASA NLADEPVPDA EPEDGLLGVR AQCRRASDLA GSVDTGSAGS 1000
    VKSIAAMLEL SSIGGGGRAA RRPPEGHPTP RPASPEPGRV ATVLASVKHK 1050
    EAIGPGGEVV NRRRTLSGPV TGLLATARRG PGESADPGPF VEDGTGRQRP 1100
    RGPSKGEAGV EGPPLAKVEA SATLKRRIRA KQNQQENVKF ILTESDTVKR 1150
    RPKAKEREAG PEPPPPLSVY HNGTGTVRRR PASEQAGPPE LPPPPPPAEP 1200
    PPTDLAHLPP LPPPEGEARK PAKPPVSPKP VLTQPVPKLQ GSPTPTSKKV 1250
    PLPGPGSPEV KRAHGTPPPV SPKPPPPPTA PKPVKAVAGL PSGSAGPSPA 1300
    PSPARQPPAA LAKPPGTPPS LGASPAKPPS PGAPALHVPA KPPRAAAAAA 1350
    AAAAAPPAPP EGASPGDSAR QKLEETSACL AAALQAVEEK IRQEDAQGPR 1400
    DSAAEKSTGS ILDDIGSMFD DLADQLDAML E 1431
    Length:1,431
    Mass (Da):149,814
    Last modified:March 1, 2002 - v1
    Checksum:iCDF60E68B81E884A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti278 – 2781R → P in BAA92544. (PubMed:10718198)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF451977 mRNA. Translation: AAL49758.1.
    AB037727 mRNA. Translation: BAA92544.1.
    CCDSiCCDS42103.1.
    RefSeqiNP_065815.1. NM_020764.3.
    UniGeneiHs.643537.

    Genome annotation databases

    EnsembliENST00000343516; ENSP00000345436; ENSG00000167971.
    GeneIDi57524.
    KEGGihsa:57524.
    UCSCiuc010bsg.1. human.

    Polymorphism databases

    DMDMi61213003.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF451977 mRNA. Translation: AAL49758.1 .
    AB037727 mRNA. Translation: BAA92544.1 .
    CCDSi CCDS42103.1.
    RefSeqi NP_065815.1. NM_020764.3.
    UniGenei Hs.643537.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3SEI X-ray 2.40 A/B 470-605 [» ]
    3SEN X-ray 3.10 A/B/C/D 470-613 [» ]
    ProteinModelPortali Q8WXD9.
    SMRi Q8WXD9. Positions 19-348, 472-613.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121585. 1 interaction.
    DIPi DIP-34890N.
    IntActi Q8WXD9. 1 interaction.
    STRINGi 9606.ENSP00000345436.

    PTM databases

    PhosphoSitei Q8WXD9.

    Polymorphism databases

    DMDMi 61213003.

    Proteomic databases

    MaxQBi Q8WXD9.
    PaxDbi Q8WXD9.
    PRIDEi Q8WXD9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343516 ; ENSP00000345436 ; ENSG00000167971 .
    GeneIDi 57524.
    KEGGi hsa:57524.
    UCSCi uc010bsg.1. human.

    Organism-specific databases

    CTDi 57524.
    GeneCardsi GC16M002227.
    HGNCi HGNC:20879. CASKIN1.
    HPAi HPA055990.
    MIMi 612184. gene.
    neXtProti NX_Q8WXD9.
    PharmGKBi PA134878267.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000049168.
    HOVERGENi HBG051133.
    InParanoidi Q8WXD9.
    OMAi PKIQGSP.
    OrthoDBi EOG7V49XK.
    PhylomeDBi Q8WXD9.
    TreeFami TF320582.

    Miscellaneous databases

    GenomeRNAii 57524.
    NextBioi 63914.
    PROi Q8WXD9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WXD9.
    Bgeei Q8WXD9.
    CleanExi HS_CASKIN1.
    Genevestigatori Q8WXD9.

    Family and domain databases

    Gene3Di 1.10.150.50. 2 hits.
    1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR027013. Caskin-1.
    IPR027001. Caskin/Ankyrin_rpt_con_pro.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR24177. PTHR24177. 1 hit.
    PTHR24177:SF12. PTHR24177:SF12. 1 hit.
    Pfami PF12796. Ank_2. 2 hits.
    PF00536. SAM_1. 2 hits.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 6 hits.
    SM00454. SAM. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 2 hits.
    SSF48403. SSF48403. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 6 hits.
    PS50105. SAM_DOMAIN. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with Caskin 1, a novel CASK-binding protein."
      Tabuchi K., Biederer T., Butz S., Suedhof T.C.
      J. Neurosci. 22:4264-4273(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 278-1431.
      Tissue: Brain.
    3. "Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK."
      Stafford R.L., Hinde E., Knight M.J., Pennella M.A., Ear J., Digman M.A., Gratton E., Bowie J.U.
      Structure 19:1826-1836(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 470-605, SUBUNIT.

    Entry informationi

    Entry nameiCSKI1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXD9
    Secondary accession number(s): Q9P2P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3