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Q8WXD2 (SCG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secretogranin-3
Alternative name(s):
Secretogranin III
Short name=SgIII
Gene names
Name:SCG3
ORF Names:UNQ2502/PRO5990
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with CHGA By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesicle lumen By similarity. Cytoplasmic vesiclesecretory vesicle membrane; Peripheral membrane protein By similarity. Secreted. Note: Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions By similarity. Neuroendocrine and endocrine secretory granules.

Tissue specificity

Expressed in brain, heart, kidney, liver and skeletal muscle. Ref.2

Post-translational modification

O-glycosylated. Ref.9

Polymorphism

Polymorphisms in the 5'-flanking region and in intron 1 may have an effect on transcriptional activity and be associated with an increase in subcutaneous, but not visceral, fat area. Hence, may influence the risk of obesity.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WXD2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WXD2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 468449Secretogranin-3
PRO_0000005461

Amino acid modifications

Glycosylation2161O-linked (GalNAc...) Ref.9
Glycosylation2311O-linked (GalNAc...) Ref.9
Glycosylation3591O-linked (GalNAc...) Ref.9

Natural variations

Alternative sequence1 – 232232Missing in isoform 2.
VSP_042876
Natural variant1251S → N.
Corresponds to variant rs2305710 [ dbSNP | Ensembl ].
VAR_013827
Natural variant1671V → A. Ref.7
Corresponds to variant rs17851186 [ dbSNP | Ensembl ].
VAR_067273
Natural variant2331M → V.
Corresponds to variant rs35664837 [ dbSNP | Ensembl ].
VAR_034484

Experimental info

Sequence conflict791K → R in AAD44483. Ref.1
Sequence conflict1501D → G in BAG52108. Ref.4
Sequence conflict272 – 2743EEL → RDF in AAD44483. Ref.1
Sequence conflict4211K → R in BAG59111. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 13, 2004. Version 3.
Checksum: 5E6BBDDFFF3B8D82

FASTA46853,005
        10         20         30         40         50         60 
MGFLGTGTWI LVLVLPIQAF PKPGGSQDKS LHNRELSAER PLNEQIAEAE EDKIKKTYPP 

        70         80         90        100        110        120 
ENKPGQSNYS FVDNLNLLKA ITEKEKIEKE RQSIRSSPLD NKLNVEDVDS TKNRKLIDDY 

       130        140        150        160        170        180 
DSTKSGLDHK FQDDPDGLHQ LDGTPLTAED IVHKIAARIY EENDRAVFDK IVSKLLNLGL 

       190        200        210        220        230        240 
ITESQAHTLE DEVAEVLQKL ISKEANNYEE DPNKPTSWTE NQAGKIPEKV TPMAAIQDGL 

       250        260        270        280        290        300 
AKGENDETVS NTLTLTNGLE RRTKTYSEDN FEELQYFPNF YALLKSIDSE KEAKEKETLI 

       310        320        330        340        350        360 
TIMKTLIDFV KMMVKYGTIS PEEGVSYLEN LDEMIALQTK NKLEKNATDN ISKLFPAPSE 

       370        380        390        400        410        420 
KSHEETDSTK EEAAKMEKEY GSLKDSTKDD NSNPGGKTDE PKGKTEAYLE AIRKNIEWLK 

       430        440        450        460 
KHDKKGNKED YDLSKMRDFI NKQADAYVEK GILDKEEAEA IKRIYSSL 

« Hide

Isoform 2 [UniParc].

Checksum: 8B855AF34EBA3A0E
Show »

FASTA23626,909

References

« Hide 'large scale' references
[1]"Human secretogranin III mRNA, complete cds."
Song H., Peng Y., Huang Q., Dai M., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Pituitary.
[2]"Cloning and characterization of a novel human secretory protein: secretogranin III."
Rong Y.P., Liu F., Zeng L.C., Ma W.J., Wei D.Z., Han Z.G.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:411-417(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Retinoblastoma and Thalamus.
[5]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-167.
Tissue: Brain and Lung.
[8]"Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity."
Tanabe A., Yanagiya T., Iida A., Saito S., Sekine A., Takahashi A., Nakamura T., Tsunoda T., Kamohara S., Nakata Y., Kotani K., Komatsu R., Itoh N., Mineo I., Wada J., Funahashi T., Miyazaki S., Tokunaga K. expand/collapse author list , Hamaguchi K., Shimada T., Tanaka K., Yamada K., Hanafusa T., Oikawa S., Yoshimatsu H., Sakata T., Matsuzawa Y., Kamatani N., Nakamura Y., Hotta K.
J. Clin. Endocrinol. Metab. 92:1145-1154(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.
[9]"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
Halim A., Ruetschi U., Larson G., Nilsson J.
J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT THR-216; THR-231 AND SER-359, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF078851 mRNA. Translation: AAD44483.1.
AF453583 mRNA. Translation: AAL67431.1.
AY359093 mRNA. Translation: AAQ89451.1.
AK075314 mRNA. Translation: BAG52108.1.
AK290175 mRNA. Translation: BAF82864.1.
AK296466 mRNA. Translation: BAG59111.1.
AC020892 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77426.1.
BC009511 mRNA. Translation: AAH09511.2.
BC014539 mRNA. Translation: AAH14539.1.
RefSeqNP_001158729.1. NM_001165257.1.
NP_037375.2. NM_013243.3.
UniGeneHs.232618.

3D structure databases

ProteinModelPortalQ8WXD2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118874. 1 interaction.
STRING9606.ENSP00000220478.

PTM databases

PhosphoSiteQ8WXD2.

Polymorphism databases

DMDM46397796.

Proteomic databases

PaxDbQ8WXD2.
PeptideAtlasQ8WXD2.
PRIDEQ8WXD2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000220478; ENSP00000220478; ENSG00000104112. [Q8WXD2-1]
ENST00000542355; ENSP00000445205; ENSG00000104112. [Q8WXD2-2]
GeneID29106.
KEGGhsa:29106.
UCSCuc002abh.3. human. [Q8WXD2-1]

Organism-specific databases

CTD29106.
GeneCardsGC15P051973.
HGNCHGNC:13707. SCG3.
HPAHPA006880.
MIM611796. gene.
neXtProtNX_Q8WXD2.
PharmGKBPA34988.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42789.
HOGENOMHOG000247064.
HOVERGENHBG057085.
InParanoidQ8WXD2.
OMAKTDEPKG.
OrthoDBEOG7G1V64.
PhylomeDBQ8WXD2.
TreeFamTF331266.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.

Gene expression databases

ArrayExpressQ8WXD2.
BgeeQ8WXD2.
CleanExHS_SCG3.
GenevestigatorQ8WXD2.

Family and domain databases

InterProIPR026197. SCG3.
[Graphical view]
PANTHERPTHR17388. PTHR17388. 1 hit.
PfamPF15467. SGIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSCG3.
GenomeRNAi29106.
NextBio52161.
PROQ8WXD2.
SOURCESearch...

Entry information

Entry nameSCG3_HUMAN
AccessionPrimary (citable) accession number: Q8WXD2
Secondary accession number(s): A8K2B0 expand/collapse secondary AC list , B3KQP6, B4DK99, F5H3R8, Q96C83, Q96GE8, Q9Y6G7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: April 13, 2004
Last modified: April 16, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM