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Q8WXD2

- SCG3_HUMAN

UniProt

Q8WXD2 - SCG3_HUMAN

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Protein

Secretogranin-3

Gene

SCG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. platelet activation Source: Reactome
  3. platelet degranulation Source: Reactome
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-3
Alternative name(s):
Secretogranin III
Short name:
SgIII
Gene namesi
Name:SCG3
ORF Names:UNQ2502/PRO5990
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:13707. SCG3.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicle lumen By similarity. Cytoplasmic vesiclesecretory vesicle membrane By similarity; Peripheral membrane protein By similarity. Secreted
Note: Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions (By similarity). Neuroendocrine and endocrine secretory granules.By similarity

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. membrane Source: UniProtKB-KW
  3. secretory granule lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 468449Secretogranin-3PRO_0000005461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi216 – 2161O-linked (GalNAc...)1 Publication
Glycosylationi231 – 2311O-linked (GalNAc...)1 Publication
Glycosylationi359 – 3591O-linked (GalNAc...)1 Publication

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ8WXD2.
PeptideAtlasiQ8WXD2.
PRIDEiQ8WXD2.

PTM databases

PhosphoSiteiQ8WXD2.

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ8WXD2.
CleanExiHS_SCG3.
ExpressionAtlasiQ8WXD2. baseline and differential.
GenevestigatoriQ8WXD2.

Organism-specific databases

HPAiHPA006880.

Interactioni

Subunit structurei

Interacts with CHGA.By similarity

Protein-protein interaction databases

BioGridi118874. 1 interaction.
STRINGi9606.ENSP00000220478.

Structurei

3D structure databases

ProteinModelPortaliQ8WXD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42789.
GeneTreeiENSGT00390000005488.
HOGENOMiHOG000247064.
HOVERGENiHBG057085.
InParanoidiQ8WXD2.
OMAiKTDEPKG.
OrthoDBiEOG7G1V64.
PhylomeDBiQ8WXD2.
TreeFamiTF331266.

Family and domain databases

InterProiIPR026197. SCG3.
[Graphical view]
PANTHERiPTHR17388. PTHR17388. 1 hit.
PfamiPF15467. SGIII. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WXD2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLGTGTWI LVLVLPIQAF PKPGGSQDKS LHNRELSAER PLNEQIAEAE
60 70 80 90 100
EDKIKKTYPP ENKPGQSNYS FVDNLNLLKA ITEKEKIEKE RQSIRSSPLD
110 120 130 140 150
NKLNVEDVDS TKNRKLIDDY DSTKSGLDHK FQDDPDGLHQ LDGTPLTAED
160 170 180 190 200
IVHKIAARIY EENDRAVFDK IVSKLLNLGL ITESQAHTLE DEVAEVLQKL
210 220 230 240 250
ISKEANNYEE DPNKPTSWTE NQAGKIPEKV TPMAAIQDGL AKGENDETVS
260 270 280 290 300
NTLTLTNGLE RRTKTYSEDN FEELQYFPNF YALLKSIDSE KEAKEKETLI
310 320 330 340 350
TIMKTLIDFV KMMVKYGTIS PEEGVSYLEN LDEMIALQTK NKLEKNATDN
360 370 380 390 400
ISKLFPAPSE KSHEETDSTK EEAAKMEKEY GSLKDSTKDD NSNPGGKTDE
410 420 430 440 450
PKGKTEAYLE AIRKNIEWLK KHDKKGNKED YDLSKMRDFI NKQADAYVEK
460
GILDKEEAEA IKRIYSSL
Length:468
Mass (Da):53,005
Last modified:April 13, 2004 - v3
Checksum:i5E6BBDDFFF3B8D82
GO
Isoform 2 (identifier: Q8WXD2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: Missing.

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):26,909
Checksum:i8B855AF34EBA3A0E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791K → R in AAD44483. 1 PublicationCurated
Sequence conflicti150 – 1501D → G in BAG52108. (PubMed:14702039)Curated
Sequence conflicti272 – 2743EEL → RDF in AAD44483. 1 PublicationCurated
Sequence conflicti421 – 4211K → R in BAG59111. (PubMed:14702039)Curated

Polymorphismi

Polymorphisms in the 5'-flanking region and in intron 1 may have an effect on transcriptional activity and be associated with an increase in subcutaneous, but not visceral, fat area. Hence, may influence the risk of obesity.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251S → N.
Corresponds to variant rs2305710 [ dbSNP | Ensembl ].
VAR_013827
Natural varianti167 – 1671V → A.1 Publication
Corresponds to variant rs17851186 [ dbSNP | Ensembl ].
VAR_067273
Natural varianti233 – 2331M → V.
Corresponds to variant rs35664837 [ dbSNP | Ensembl ].
VAR_034484

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 232232Missing in isoform 2. 1 PublicationVSP_042876Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF078851 mRNA. Translation: AAD44483.1.
AF453583 mRNA. Translation: AAL67431.1.
AY359093 mRNA. Translation: AAQ89451.1.
AK075314 mRNA. Translation: BAG52108.1.
AK290175 mRNA. Translation: BAF82864.1.
AK296466 mRNA. Translation: BAG59111.1.
AC020892 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77426.1.
BC009511 mRNA. Translation: AAH09511.2.
BC014539 mRNA. Translation: AAH14539.1.
CCDSiCCDS10142.1. [Q8WXD2-1]
CCDS53947.1. [Q8WXD2-2]
RefSeqiNP_001158729.1. NM_001165257.1. [Q8WXD2-2]
NP_037375.2. NM_013243.3. [Q8WXD2-1]
UniGeneiHs.232618.

Genome annotation databases

EnsembliENST00000220478; ENSP00000220478; ENSG00000104112. [Q8WXD2-1]
ENST00000542355; ENSP00000445205; ENSG00000104112. [Q8WXD2-2]
GeneIDi29106.
KEGGihsa:29106.
UCSCiuc002abh.3. human. [Q8WXD2-1]

Polymorphism databases

DMDMi46397796.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF078851 mRNA. Translation: AAD44483.1 .
AF453583 mRNA. Translation: AAL67431.1 .
AY359093 mRNA. Translation: AAQ89451.1 .
AK075314 mRNA. Translation: BAG52108.1 .
AK290175 mRNA. Translation: BAF82864.1 .
AK296466 mRNA. Translation: BAG59111.1 .
AC020892 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77426.1 .
BC009511 mRNA. Translation: AAH09511.2 .
BC014539 mRNA. Translation: AAH14539.1 .
CCDSi CCDS10142.1. [Q8WXD2-1 ]
CCDS53947.1. [Q8WXD2-2 ]
RefSeqi NP_001158729.1. NM_001165257.1. [Q8WXD2-2 ]
NP_037375.2. NM_013243.3. [Q8WXD2-1 ]
UniGenei Hs.232618.

3D structure databases

ProteinModelPortali Q8WXD2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118874. 1 interaction.
STRINGi 9606.ENSP00000220478.

PTM databases

PhosphoSitei Q8WXD2.

Polymorphism databases

DMDMi 46397796.

Proteomic databases

PaxDbi Q8WXD2.
PeptideAtlasi Q8WXD2.
PRIDEi Q8WXD2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000220478 ; ENSP00000220478 ; ENSG00000104112 . [Q8WXD2-1 ]
ENST00000542355 ; ENSP00000445205 ; ENSG00000104112 . [Q8WXD2-2 ]
GeneIDi 29106.
KEGGi hsa:29106.
UCSCi uc002abh.3. human. [Q8WXD2-1 ]

Organism-specific databases

CTDi 29106.
GeneCardsi GC15P051973.
HGNCi HGNC:13707. SCG3.
HPAi HPA006880.
MIMi 611796. gene.
neXtProti NX_Q8WXD2.
PharmGKBi PA34988.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42789.
GeneTreei ENSGT00390000005488.
HOGENOMi HOG000247064.
HOVERGENi HBG057085.
InParanoidi Q8WXD2.
OMAi KTDEPKG.
OrthoDBi EOG7G1V64.
PhylomeDBi Q8WXD2.
TreeFami TF331266.

Miscellaneous databases

GeneWikii SCG3.
GenomeRNAii 29106.
NextBioi 52161.
PROi Q8WXD2.
SOURCEi Search...

Gene expression databases

Bgeei Q8WXD2.
CleanExi HS_SCG3.
ExpressionAtlasi Q8WXD2. baseline and differential.
Genevestigatori Q8WXD2.

Family and domain databases

InterProi IPR026197. SCG3.
[Graphical view ]
PANTHERi PTHR17388. PTHR17388. 1 hit.
Pfami PF15467. SGIII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human secretogranin III mRNA, complete cds."
    Song H., Peng Y., Huang Q., Dai M., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Pituitary.
  2. "Cloning and characterization of a novel human secretory protein: secretogranin III."
    Rong Y.P., Liu F., Zeng L.C., Ma W.J., Wei D.Z., Han Z.G.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:411-417(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Retinoblastoma and Thalamus.
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-167.
    Tissue: Brain and Lung.
  8. Cited for: POLYMORPHISM.
  9. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
    Halim A., Ruetschi U., Larson G., Nilsson J.
    J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-216; THR-231 AND SER-359, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSCG3_HUMAN
AccessioniPrimary (citable) accession number: Q8WXD2
Secondary accession number(s): A8K2B0
, B3KQP6, B4DK99, F5H3R8, Q96C83, Q96GE8, Q9Y6G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: April 13, 2004
Last modified: October 29, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3