Q8WXD2 (SCG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Secretogranin-3

Alternative name(s):
Secretogranin III
Short name=SgIII

Gene names

Name:	SCG3
ORF Names:	UNQ2502/PRO5990

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with CHGA By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle lumen By similarity. Cytoplasmic vesicle › secretory vesicle membrane; Peripheral membrane protein By similarity. Secreted. Note: Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions By similarity. Neuroendocrine and endocrine secretory granules.
Tissue specificity	Expressed in brain, heart, kidney, liver and skeletal muscle. Ref.2
Post-translational modification	O-glycosylated. Ref.9
Polymorphism	Polymorphisms in the 5'-flanking region and in intron 1 may have an effect on transcriptional activity and be associated with an increase in subcutaneous, but not visceral, fat area. Hence, may influence the risk of obesity.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	platelet activation Traceable author statement. Source: Reactome platelet degranulation Traceable author statement. Source: Reactome
Cellular_component	extracellular region Traceable author statement. Source: Reactome secretory granule Traceable author statement. Source: Reactome transport vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WXD2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WXD2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 468	449	Secretogranin-3		PRO_0000005461
Amino acid modifications
	Glycosylation	216	1	O-linked (GalNAc...) Ref.9
	Glycosylation	231	1	O-linked (GalNAc...) Ref.9
	Glycosylation	359	1	O-linked (GalNAc...) Ref.9
Natural variations
	Alternative sequence	1 – 232	232	Missing in isoform 2.		VSP_042876
	Natural variant	125	1	S → N. Corresponds to variant rs2305710 [ dbSNP | Ensembl ].		VAR_013827
	Natural variant	167	1	V → A. Ref.7 Corresponds to variant rs17851186 [ dbSNP | Ensembl ].		VAR_067273
	Natural variant	233	1	M → V. Corresponds to variant rs35664837 [ dbSNP | Ensembl ].		VAR_034484
Experimental info
	Sequence conflict	79	1	K → R in AAD44483. Ref.1
	Sequence conflict	150	1	D → G in BAG52108. Ref.4
	Sequence conflict	272 – 274	3	EEL → RDF in AAD44483. Ref.1
	Sequence conflict	421	1	K → R in BAG59111. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 13, 2004. Version 3. Checksum: 5E6BBDDFFF3B8D82	FASTA	468	53,005
	10 20 30 40 50 60 MGFLGTGTWI LVLVLPIQAF PKPGGSQDKS LHNRELSAER PLNEQIAEAE EDKIKKTYPP 70 80 90 100 110 120 ENKPGQSNYS FVDNLNLLKA ITEKEKIEKE RQSIRSSPLD NKLNVEDVDS TKNRKLIDDY 130 140 150 160 170 180 DSTKSGLDHK FQDDPDGLHQ LDGTPLTAED IVHKIAARIY EENDRAVFDK IVSKLLNLGL 190 200 210 220 230 240 ITESQAHTLE DEVAEVLQKL ISKEANNYEE DPNKPTSWTE NQAGKIPEKV TPMAAIQDGL 250 260 270 280 290 300 AKGENDETVS NTLTLTNGLE RRTKTYSEDN FEELQYFPNF YALLKSIDSE KEAKEKETLI 310 320 330 340 350 360 TIMKTLIDFV KMMVKYGTIS PEEGVSYLEN LDEMIALQTK NKLEKNATDN ISKLFPAPSE 370 380 390 400 410 420 KSHEETDSTK EEAAKMEKEY GSLKDSTKDD NSNPGGKTDE PKGKTEAYLE AIRKNIEWLK 430 440 450 460 KHDKKGNKED YDLSKMRDFI NKQADAYVEK GILDKEEAEA IKRIYSSL
	Isoform 2 [UniParc]. Checksum: 8B855AF34EBA3A0E	FASTA	236	26,909
	10 20 30 40 50 60 MAAIQDGLAK GENDETVSNT LTLTNGLERR TKTYSEDNFE ELQYFPNFYA LLKSIDSEKE 70 80 90 100 110 120 AKEKETLITI MKTLIDFVKM MVKYGTISPE EGVSYLENLD EMIALQTKNK LEKNATDNIS 130 140 150 160 170 180 KLFPAPSEKS HEETDSTKEE AAKMEKEYGS LKDSTKDDNS NPGGKTDEPK GKTEAYLEAI 190 200 210 220 230 RKNIEWLKKH DKKGNKEDYD LSKMRDFINK QADAYVEKGI LDKEEAEAIK RIYSSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human secretogranin III mRNA, complete cds." Song H., Peng Y., Huang Q., Dai M., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Pituitary.
[2]	"Cloning and characterization of a novel human secretory protein: secretogranin III." Rong Y.P., Liu F., Zeng L.C., Ma W.J., Wei D.Z., Han Z.G. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:411-417(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Retinoblastoma and Thalamus.
[5]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-167. Tissue: Brain and Lung.
[8]	"Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity." Tanabe A., Yanagiya T., Iida A., Saito S., Sekine A., Takahashi A., Nakamura T., Tsunoda T., Kamohara S., Nakata Y., Kotani K., Komatsu R., Itoh N., Mineo I., Wada J., Funahashi T., Miyazaki S., Tokunaga K. , Hamaguchi K., Shimada T., Tanaka K., Yamada K., Hanafusa T., Oikawa S., Yoshimatsu H., Sakata T., Matsuzawa Y., Kamatani N., Nakamura Y., Hotta K. J. Clin. Endocrinol. Metab. 92:1145-1154(2007) [PubMed] [Europe PMC] [Abstract] Cited for: POLYMORPHISM.
[9]	"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins." Halim A., Ruetschi U., Larson G., Nilsson J. J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT THR-216; THR-231 AND SER-359, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF078851 mRNA. Translation: AAD44483.1. AF453583 mRNA. Translation: AAL67431.1. AY359093 mRNA. Translation: AAQ89451.1. AK075314 mRNA. Translation: BAG52108.1. AK290175 mRNA. Translation: BAF82864.1. AK296466 mRNA. Translation: BAG59111.1. AC020892 Genomic DNA. No translation available. CH471082 Genomic DNA. Translation: EAW77426.1. BC009511 mRNA. Translation: AAH09511.2. BC014539 mRNA. Translation: AAH14539.1.
IPI	IPI00292071.
RefSeq	NP_001158729.1. NM_001165257.1. NP_037375.2. NM_013243.3.
UniGene	Hs.232618.
3D structure databases
ProteinModelPortal	Q8WXD2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000220478.
PTM databases
PhosphoSite	Q8WXD2.
Polymorphism databases
DMDM	46397796.
Proteomic databases
PaxDb	Q8WXD2.
PeptideAtlas	Q8WXD2.
PRIDE	Q8WXD2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000220478; ENSP00000220478; ENSG00000104112. ENST00000542355; ENSP00000445205; ENSG00000104112.
GeneID	29106.
KEGG	hsa:29106.
UCSC	uc002abh.3. human.
Organism-specific databases
CTD	29106.
GeneCards	GC15P051973.
HGNC	HGNC:13707. SCG3.
HPA	HPA006880.
MIM	611796. gene.
neXtProt	NX_Q8WXD2.
PharmGKB	PA34988.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42789.
HOGENOM	HOG000247064.
HOVERGEN	HBG057085.
InParanoid	Q8WXD2.
OMA	KTDEPKG.
OrthoDB	EOG4STS4Q.
PhylomeDB	Q8WXD2.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q8WXD2.
Bgee	Q8WXD2.
CleanEx	HS_SCG3.
Genevestigator	Q8WXD2.
GermOnline	ENSG00000104112. Homo sapiens.
Family and domain databases
InterPro	IPR026197. SCG3. [Graphical view]
PANTHER	PTHR17388. PTHR17388. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	29106.
NextBio	52161.
SOURCE	Search...

Entry information

Entry name

SCG3_HUMAN

Accession

Primary (citable) accession number: Q8WXD2
Secondary accession number(s): A8K2B0 , B3KQP6, B4DK99, F5H3R8, Q96C83, Q96GE8, Q9Y6G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	April 13, 2004
Last modified:	May 1, 2013
This is version 98 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.