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Q8WXD2

- SCG3_HUMAN

UniProt

Q8WXD2 - SCG3_HUMAN

Protein

Secretogranin-3

Gene

SCG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 3 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. platelet activation Source: Reactome
    3. platelet degranulation Source: Reactome

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secretogranin-3
    Alternative name(s):
    Secretogranin III
    Short name:
    SgIII
    Gene namesi
    Name:SCG3
    ORF Names:UNQ2502/PRO5990
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:13707. SCG3.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicle lumen By similarity. Cytoplasmic vesiclesecretory vesicle membrane By similarity; Peripheral membrane protein By similarity. Secreted
    Note: Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions By similarity. Neuroendocrine and endocrine secretory granules.By similarity

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. secretory granule lumen Source: Reactome
    3. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34988.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 468449Secretogranin-3PRO_0000005461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi216 – 2161O-linked (GalNAc...)1 Publication
    Glycosylationi231 – 2311O-linked (GalNAc...)1 Publication
    Glycosylationi359 – 3591O-linked (GalNAc...)1 Publication

    Post-translational modificationi

    O-glycosylated.1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    PaxDbiQ8WXD2.
    PeptideAtlasiQ8WXD2.
    PRIDEiQ8WXD2.

    PTM databases

    PhosphoSiteiQ8WXD2.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, kidney, liver and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ8WXD2.
    BgeeiQ8WXD2.
    CleanExiHS_SCG3.
    GenevestigatoriQ8WXD2.

    Organism-specific databases

    HPAiHPA006880.

    Interactioni

    Subunit structurei

    Interacts with CHGA.By similarity

    Protein-protein interaction databases

    BioGridi118874. 1 interaction.
    STRINGi9606.ENSP00000220478.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42789.
    HOGENOMiHOG000247064.
    HOVERGENiHBG057085.
    InParanoidiQ8WXD2.
    OMAiKTDEPKG.
    OrthoDBiEOG7G1V64.
    PhylomeDBiQ8WXD2.
    TreeFamiTF331266.

    Family and domain databases

    InterProiIPR026197. SCG3.
    [Graphical view]
    PANTHERiPTHR17388. PTHR17388. 1 hit.
    PfamiPF15467. SGIII. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WXD2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFLGTGTWI LVLVLPIQAF PKPGGSQDKS LHNRELSAER PLNEQIAEAE    50
    EDKIKKTYPP ENKPGQSNYS FVDNLNLLKA ITEKEKIEKE RQSIRSSPLD 100
    NKLNVEDVDS TKNRKLIDDY DSTKSGLDHK FQDDPDGLHQ LDGTPLTAED 150
    IVHKIAARIY EENDRAVFDK IVSKLLNLGL ITESQAHTLE DEVAEVLQKL 200
    ISKEANNYEE DPNKPTSWTE NQAGKIPEKV TPMAAIQDGL AKGENDETVS 250
    NTLTLTNGLE RRTKTYSEDN FEELQYFPNF YALLKSIDSE KEAKEKETLI 300
    TIMKTLIDFV KMMVKYGTIS PEEGVSYLEN LDEMIALQTK NKLEKNATDN 350
    ISKLFPAPSE KSHEETDSTK EEAAKMEKEY GSLKDSTKDD NSNPGGKTDE 400
    PKGKTEAYLE AIRKNIEWLK KHDKKGNKED YDLSKMRDFI NKQADAYVEK 450
    GILDKEEAEA IKRIYSSL 468
    Length:468
    Mass (Da):53,005
    Last modified:April 13, 2004 - v3
    Checksum:i5E6BBDDFFF3B8D82
    GO
    Isoform 2 (identifier: Q8WXD2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-232: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:236
    Mass (Da):26,909
    Checksum:i8B855AF34EBA3A0E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791K → R in AAD44483. 1 PublicationCurated
    Sequence conflicti150 – 1501D → G in BAG52108. (PubMed:14702039)Curated
    Sequence conflicti272 – 2743EEL → RDF in AAD44483. 1 PublicationCurated
    Sequence conflicti421 – 4211K → R in BAG59111. (PubMed:14702039)Curated

    Polymorphismi

    Polymorphisms in the 5'-flanking region and in intron 1 may have an effect on transcriptional activity and be associated with an increase in subcutaneous, but not visceral, fat area. Hence, may influence the risk of obesity.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti125 – 1251S → N.
    Corresponds to variant rs2305710 [ dbSNP | Ensembl ].
    VAR_013827
    Natural varianti167 – 1671V → A.1 Publication
    Corresponds to variant rs17851186 [ dbSNP | Ensembl ].
    VAR_067273
    Natural varianti233 – 2331M → V.
    Corresponds to variant rs35664837 [ dbSNP | Ensembl ].
    VAR_034484

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 232232Missing in isoform 2. 1 PublicationVSP_042876Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF078851 mRNA. Translation: AAD44483.1.
    AF453583 mRNA. Translation: AAL67431.1.
    AY359093 mRNA. Translation: AAQ89451.1.
    AK075314 mRNA. Translation: BAG52108.1.
    AK290175 mRNA. Translation: BAF82864.1.
    AK296466 mRNA. Translation: BAG59111.1.
    AC020892 Genomic DNA. No translation available.
    CH471082 Genomic DNA. Translation: EAW77426.1.
    BC009511 mRNA. Translation: AAH09511.2.
    BC014539 mRNA. Translation: AAH14539.1.
    CCDSiCCDS10142.1. [Q8WXD2-1]
    CCDS53947.1. [Q8WXD2-2]
    RefSeqiNP_001158729.1. NM_001165257.1. [Q8WXD2-2]
    NP_037375.2. NM_013243.3. [Q8WXD2-1]
    UniGeneiHs.232618.

    Genome annotation databases

    EnsembliENST00000220478; ENSP00000220478; ENSG00000104112. [Q8WXD2-1]
    ENST00000542355; ENSP00000445205; ENSG00000104112. [Q8WXD2-2]
    GeneIDi29106.
    KEGGihsa:29106.
    UCSCiuc002abh.3. human. [Q8WXD2-1]

    Polymorphism databases

    DMDMi46397796.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF078851 mRNA. Translation: AAD44483.1 .
    AF453583 mRNA. Translation: AAL67431.1 .
    AY359093 mRNA. Translation: AAQ89451.1 .
    AK075314 mRNA. Translation: BAG52108.1 .
    AK290175 mRNA. Translation: BAF82864.1 .
    AK296466 mRNA. Translation: BAG59111.1 .
    AC020892 Genomic DNA. No translation available.
    CH471082 Genomic DNA. Translation: EAW77426.1 .
    BC009511 mRNA. Translation: AAH09511.2 .
    BC014539 mRNA. Translation: AAH14539.1 .
    CCDSi CCDS10142.1. [Q8WXD2-1 ]
    CCDS53947.1. [Q8WXD2-2 ]
    RefSeqi NP_001158729.1. NM_001165257.1. [Q8WXD2-2 ]
    NP_037375.2. NM_013243.3. [Q8WXD2-1 ]
    UniGenei Hs.232618.

    3D structure databases

    ProteinModelPortali Q8WXD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118874. 1 interaction.
    STRINGi 9606.ENSP00000220478.

    PTM databases

    PhosphoSitei Q8WXD2.

    Polymorphism databases

    DMDMi 46397796.

    Proteomic databases

    PaxDbi Q8WXD2.
    PeptideAtlasi Q8WXD2.
    PRIDEi Q8WXD2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000220478 ; ENSP00000220478 ; ENSG00000104112 . [Q8WXD2-1 ]
    ENST00000542355 ; ENSP00000445205 ; ENSG00000104112 . [Q8WXD2-2 ]
    GeneIDi 29106.
    KEGGi hsa:29106.
    UCSCi uc002abh.3. human. [Q8WXD2-1 ]

    Organism-specific databases

    CTDi 29106.
    GeneCardsi GC15P051973.
    HGNCi HGNC:13707. SCG3.
    HPAi HPA006880.
    MIMi 611796. gene.
    neXtProti NX_Q8WXD2.
    PharmGKBi PA34988.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42789.
    HOGENOMi HOG000247064.
    HOVERGENi HBG057085.
    InParanoidi Q8WXD2.
    OMAi KTDEPKG.
    OrthoDBi EOG7G1V64.
    PhylomeDBi Q8WXD2.
    TreeFami TF331266.

    Miscellaneous databases

    GeneWikii SCG3.
    GenomeRNAii 29106.
    NextBioi 52161.
    PROi Q8WXD2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WXD2.
    Bgeei Q8WXD2.
    CleanExi HS_SCG3.
    Genevestigatori Q8WXD2.

    Family and domain databases

    InterProi IPR026197. SCG3.
    [Graphical view ]
    PANTHERi PTHR17388. PTHR17388. 1 hit.
    Pfami PF15467. SGIII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human secretogranin III mRNA, complete cds."
      Song H., Peng Y., Huang Q., Dai M., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Pituitary.
    2. "Cloning and characterization of a novel human secretory protein: secretogranin III."
      Rong Y.P., Liu F., Zeng L.C., Ma W.J., Wei D.Z., Han Z.G.
      Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:411-417(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Retinoblastoma and Thalamus.
    5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-167.
      Tissue: Brain and Lung.
    8. Cited for: POLYMORPHISM.
    9. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
      Halim A., Ruetschi U., Larson G., Nilsson J.
      J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT THR-216; THR-231 AND SER-359, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiSCG3_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXD2
    Secondary accession number(s): A8K2B0
    , B3KQP6, B4DK99, F5H3R8, Q96C83, Q96GE8, Q9Y6G7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3