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Protein

COP9 signalosome complex subunit 9

Gene

COPS9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.1 Publication
Isoform 2: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.1 Publication

GO - Biological processi

  • cellular response to UV Source: UniProtKB
  • cytoplasmic sequestering of protein Source: UniProtKB
  • negative regulation of protein neddylation Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172428-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 9Curated
Alternative name(s):
CSN acidic protein1 Publication
Short name:
CSNAP1 Publication
Myeloma-overexpressed gene 2 protein1 Publication
Gene namesi
Name:COPS9Imported
Synonyms:MYEOV21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:21314. COPS9.

Subcellular locationi

Isoform 1 :
Isoform 2 :
  • Nucleusnucleoplasm 1 Publication

  • Note: Excluded from the nucleolus.1 Publication

GO - Cellular componenti

  • COP9 signalosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • nuclear chromatin Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44F → A: Does not abolish interaction with CSN complex. Abolishes interaction with CSN complex; when associated with A-51. 1 Publication1
Mutagenesisi51F → A: Decreases interaction with CSN complex. Abolishes interaction with CSN complex; when associated with A-44. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000172428.
PharmGKBiPA142671302.

Polymorphism and mutation databases

BioMutaiMYEOV2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329241 – 57COP9 signalosome complex subunit 9Add BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WXC6.
PeptideAtlasiQ8WXC6.
PRIDEiQ8WXC6.

PTM databases

iPTMnetiQ8WXC6.
PhosphoSitePlusiQ8WXC6.

Expressioni

Gene expression databases

BgeeiENSG00000172428.
CleanExiHS_MYEOV2.
ExpressionAtlasiQ8WXC6. baseline and differential.
GenevisibleiQ8WXC6. HS.

Organism-specific databases

HPAiHPA044845.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1. In the complex, it interacts directly with COPS3, COPS5 and COPS6 (PubMed:26456823). Isoform 2 associates with CSN complex (PubMed:23776465). Isoform 2 interacts with COPS5, CUL1, CUL3 and RPL11 (PubMed:23776465). According to PubMed:26456823, does not associate with CSN complex.2 Publications

Protein-protein interaction databases

BioGridi127315. 17 interactors.
IntActiQ8WXC6. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ8WXC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi52 – 55Poly-Asp4

Domaini

Isoform 1: The Phe/Asp-rich domain at the C-terminus is necessary for its incorporation into the CSN complex.1 Publication
Isoform 2: Amino acids 60-89 in isoform 2 are necessary for interaction with COPS5, CUL1, CUL3.1 Publication

Sequence similaritiesi

Belongs to the CSN9 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000000076.
HOGENOMiHOG000047756.
HOVERGENiHBG104545.
InParanoidiQ8WXC6.
OMAiRGPEMKP.
OrthoDBiEOG091G169J.
PhylomeDBiQ8WXC6.
TreeFamiTF323869.

Family and domain databases

InterProiIPR029391. MYEOV2.
[Graphical view]
PfamiPF15004. MYEOV2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXC6-2) [UniParc]FASTAAdd to basket
Also known as: CSNAP1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

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MKPAVDEMFP EGAGPYVDLD EAGGSTGLLM DLAANEKAVH ADFFNDFEDL

FDDDDIQ
Length:57
Mass (Da):6,211
Last modified:May 5, 2009 - v3
Checksum:i8306DAFBF3DC610C
GO
Isoform 2 (identifier: Q8WXC6-1) [UniParc]FASTAAdd to basket
Also known as: MYEOV2-L1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWRAPEAALRPEVSLERRGPEM
     21-21: E → EVARARRESPS
     57-57: Q → HSSGLPRTSQ...KTTQPCIDVR

Note: No experimental confirmation available.
Show »
Length:252
Mass (Da):27,665
Checksum:iB474141F1D8A815B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0370731M → MWRAPEAALRPEVSLERRGP EM in isoform 2. 1 Publication1
Alternative sequenceiVSP_03707421E → EVARARRESPS in isoform 2. 1 Publication1
Alternative sequenceiVSP_03707557Q → HSSGLPRTSQQSSMVPALQR GQSEHGVRGKAAERPVVSEE RCELNGREVAALDRAFGSTG HGQGAEALMFTRCREHPLCG TNKATSEGKMGTGRLRNSLR KNQSKWLGSYLEVLRTTRSR REVSEDSTISVSTHWRGKCF KSDETPSVAGGEEGKKTTQP CIDVR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453951 mRNA. Translation: AAL41026.1.
AF487338 mRNA. Translation: AAL96264.2.
AC013469 Genomic DNA. Translation: AAY14738.1.
CH471063 Genomic DNA. Translation: EAW71178.1.
CCDSiCCDS2532.1. [Q8WXC6-1]
CCDS63183.1. [Q8WXC6-2]
RefSeqiNP_001156896.1. NM_001163424.1. [Q8WXC6-2]
NP_612209.1. NM_138336.1. [Q8WXC6-1]
UniGeneiHs.293884.

Genome annotation databases

EnsembliENST00000307266; ENSP00000304147; ENSG00000172428. [Q8WXC6-1]
ENST00000607357; ENSP00000475979; ENSG00000172428. [Q8WXC6-2]
GeneIDi150678.
KEGGihsa:150678.
UCSCiuc002vyu.1. human. [Q8WXC6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453951 mRNA. Translation: AAL41026.1.
AF487338 mRNA. Translation: AAL96264.2.
AC013469 Genomic DNA. Translation: AAY14738.1.
CH471063 Genomic DNA. Translation: EAW71178.1.
CCDSiCCDS2532.1. [Q8WXC6-1]
CCDS63183.1. [Q8WXC6-2]
RefSeqiNP_001156896.1. NM_001163424.1. [Q8WXC6-2]
NP_612209.1. NM_138336.1. [Q8WXC6-1]
UniGeneiHs.293884.

3D structure databases

ProteinModelPortaliQ8WXC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127315. 17 interactors.
IntActiQ8WXC6. 1 interactor.

PTM databases

iPTMnetiQ8WXC6.
PhosphoSitePlusiQ8WXC6.

Polymorphism and mutation databases

BioMutaiMYEOV2.

Proteomic databases

EPDiQ8WXC6.
PeptideAtlasiQ8WXC6.
PRIDEiQ8WXC6.

Protocols and materials databases

DNASUi150678.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307266; ENSP00000304147; ENSG00000172428. [Q8WXC6-1]
ENST00000607357; ENSP00000475979; ENSG00000172428. [Q8WXC6-2]
GeneIDi150678.
KEGGihsa:150678.
UCSCiuc002vyu.1. human. [Q8WXC6-2]

Organism-specific databases

CTDi150678.
GeneCardsiMYEOV2.
HGNCiHGNC:21314. COPS9.
HPAiHPA044845.
neXtProtiNX_Q8WXC6.
OpenTargetsiENSG00000172428.
PharmGKBiPA142671302.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000000076.
HOGENOMiHOG000047756.
HOVERGENiHBG104545.
InParanoidiQ8WXC6.
OMAiRGPEMKP.
OrthoDBiEOG091G169J.
PhylomeDBiQ8WXC6.
TreeFamiTF323869.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172428-MONOMER.

Miscellaneous databases

GenomeRNAii150678.
PROiQ8WXC6.

Gene expression databases

BgeeiENSG00000172428.
CleanExiHS_MYEOV2.
ExpressionAtlasiQ8WXC6. baseline and differential.
GenevisibleiQ8WXC6. HS.

Family and domain databases

InterProiIPR029391. MYEOV2.
[Graphical view]
PfamiPF15004. MYEOV2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSN9_HUMAN
AccessioniPrimary (citable) accession number: Q8WXC6
Secondary accession number(s): Q8N110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.