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Protein

Myeloma-overexpressed gene 2 protein

Gene

MYEOV2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloma-overexpressed gene 2 protein
Gene namesi
Name:MYEOV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:21314. MYEOV2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671302.

Polymorphism and mutation databases

BioMutaiMYEOV2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5757Myeloma-overexpressed gene 2 proteinPRO_0000332924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WXC6.
PeptideAtlasiQ8WXC6.
PRIDEiQ8WXC6.

PTM databases

iPTMnetiQ8WXC6.
PhosphoSiteiQ8WXC6.

Expressioni

Gene expression databases

BgeeiENSG00000172428.
CleanExiHS_MYEOV2.
ExpressionAtlasiQ8WXC6. baseline and differential.
GenevisibleiQ8WXC6. HS.

Organism-specific databases

HPAiHPA044845.

Interactioni

Protein-protein interaction databases

BioGridi127315. 17 interactions.
IntActiQ8WXC6. 1 interaction.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 554Poly-Asp

Sequence similaritiesi

Belongs to the MYEOV2 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000000076.
HOGENOMiHOG000047756.
HOVERGENiHBG104545.
InParanoidiQ8WXC6.
OMAiRGPEMKP.
OrthoDBiEOG091G169J.
PhylomeDBiQ8WXC6.
TreeFamiTF323869.

Family and domain databases

InterProiIPR029391. MYEOV2.
[Graphical view]
PfamiPF15004. MYEOV2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXC6-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MKPAVDEMFP EGAGPYVDLD EAGGSTGLLM DLAANEKAVH ADFFNDFEDL

FDDDDIQ
Length:57
Mass (Da):6,211
Last modified:May 5, 2009 - v3
Checksum:i8306DAFBF3DC610C
GO
Isoform 2 (identifier: Q8WXC6-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWRAPEAALRPEVSLERRGPEM
     21-21: E → EVARARRESPS
     57-57: Q → HSSGLPRTSQ...KTTQPCIDVR

Note: No experimental confirmation available.
Show »
Length:252
Mass (Da):27,665
Checksum:iB474141F1D8A815B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MWRAPEAALRPEVSLERRGP EM in isoform 2. 1 PublicationVSP_037073
Alternative sequencei21 – 211E → EVARARRESPS in isoform 2. 1 PublicationVSP_037074
Alternative sequencei57 – 571Q → HSSGLPRTSQQSSMVPALQR GQSEHGVRGKAAERPVVSEE RCELNGREVAALDRAFGSTG HGQGAEALMFTRCREHPLCG TNKATSEGKMGTGRLRNSLR KNQSKWLGSYLEVLRTTRSR REVSEDSTISVSTHWRGKCF KSDETPSVAGGEEGKKTTQP CIDVR in isoform 2. 1 PublicationVSP_037075

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453951 mRNA. Translation: AAL41026.1.
AF487338 mRNA. Translation: AAL96264.2.
AC013469 Genomic DNA. Translation: AAY14738.1.
CH471063 Genomic DNA. Translation: EAW71178.1.
CCDSiCCDS2532.1. [Q8WXC6-1]
CCDS63183.1. [Q8WXC6-2]
RefSeqiNP_001156896.1. NM_001163424.1. [Q8WXC6-2]
NP_612209.1. NM_138336.1. [Q8WXC6-1]
UniGeneiHs.293884.

Genome annotation databases

EnsembliENST00000307266; ENSP00000304147; ENSG00000172428. [Q8WXC6-1]
ENST00000607357; ENSP00000475979; ENSG00000172428. [Q8WXC6-2]
GeneIDi150678.
KEGGihsa:150678.
UCSCiuc002vyu.1. human. [Q8WXC6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453951 mRNA. Translation: AAL41026.1.
AF487338 mRNA. Translation: AAL96264.2.
AC013469 Genomic DNA. Translation: AAY14738.1.
CH471063 Genomic DNA. Translation: EAW71178.1.
CCDSiCCDS2532.1. [Q8WXC6-1]
CCDS63183.1. [Q8WXC6-2]
RefSeqiNP_001156896.1. NM_001163424.1. [Q8WXC6-2]
NP_612209.1. NM_138336.1. [Q8WXC6-1]
UniGeneiHs.293884.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127315. 17 interactions.
IntActiQ8WXC6. 1 interaction.

PTM databases

iPTMnetiQ8WXC6.
PhosphoSiteiQ8WXC6.

Polymorphism and mutation databases

BioMutaiMYEOV2.

Proteomic databases

EPDiQ8WXC6.
PeptideAtlasiQ8WXC6.
PRIDEiQ8WXC6.

Protocols and materials databases

DNASUi150678.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307266; ENSP00000304147; ENSG00000172428. [Q8WXC6-1]
ENST00000607357; ENSP00000475979; ENSG00000172428. [Q8WXC6-2]
GeneIDi150678.
KEGGihsa:150678.
UCSCiuc002vyu.1. human. [Q8WXC6-2]

Organism-specific databases

CTDi150678.
GeneCardsiMYEOV2.
HGNCiHGNC:21314. MYEOV2.
HPAiHPA044845.
neXtProtiNX_Q8WXC6.
PharmGKBiPA142671302.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000000076.
HOGENOMiHOG000047756.
HOVERGENiHBG104545.
InParanoidiQ8WXC6.
OMAiRGPEMKP.
OrthoDBiEOG091G169J.
PhylomeDBiQ8WXC6.
TreeFamiTF323869.

Miscellaneous databases

GenomeRNAii150678.
PROiQ8WXC6.

Gene expression databases

BgeeiENSG00000172428.
CleanExiHS_MYEOV2.
ExpressionAtlasiQ8WXC6. baseline and differential.
GenevisibleiQ8WXC6. HS.

Family and domain databases

InterProiIPR029391. MYEOV2.
[Graphical view]
PfamiPF15004. MYEOV2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYOV2_HUMAN
AccessioniPrimary (citable) accession number: Q8WXC6
Secondary accession number(s): Q8N110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 5, 2009
Last modified: September 7, 2016
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.