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Protein

Pyrin domain-containing protein 1

Gene

PYDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrin domain-containing protein 1Curated
Alternative name(s):
PAAD-only protein 11 Publication
Pyrin-only protein 11 Publication
cellular POP11 Publication
Short name:
cPOP11 Publication
Gene namesi
Name:PYDC1Imported
Synonyms:ASC21 Publication, ASCI, POP11 Publication, PYC1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30261. PYDC1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HGNC
  • extracellular region Source: Ensembl
  • IkappaB kinase complex Source: HGNC
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671111.

Polymorphism and mutation databases

BioMutaiPYDC1.
DMDMi74730989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8989Pyrin domain-containing protein 1PRO_0000280593Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8WXC3.
PRIDEiQ8WXC3.

Expressioni

Tissue specificityi

Predominantly expressed in monocytes, macrophages and granulocytes.1 Publication

Gene expression databases

BgeeiQ8WXC3.
CleanExiHS_POP1.
HS_PYDC1.
GenevisibleiQ8WXC3. HS.

Interactioni

Subunit structurei

Interacts with PYCARD/ASC (via pyrin domain).2 Publications

Protein-protein interaction databases

BioGridi129281. 1 interaction.
IntActiQ8WXC3. 1 interaction.
STRINGi9606.ENSP00000304336.

Structurei

Secondary structure

1
89
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1310Combined sources
Helixi17 – 2711Combined sources
Helixi41 – 455Combined sources
Helixi49 – 6012Combined sources
Helixi62 – 7514Combined sources
Helixi79 – 8810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HM2NMR-Q1-89[»]
4QOBX-ray2.70A/B1-89[»]
ProteinModelPortaliQ8WXC3.
SMRiQ8WXC3. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WXC3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8989PyrinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 pyrin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410JDCM. Eukaryota.
ENOG4111636. LUCA.
GeneTreeiENSGT00440000033973.
HOGENOMiHOG000059575.
InParanoidiQ8WXC3.
KOiK12802.
OMAiDMGMREE.
OrthoDBiEOG786H4P.
PhylomeDBiQ8WXC3.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTKREAILK VLENLTPEEL KKFKMKLGTV PLREGFERIP RGALGQLDIV
60 70 80
DLTDKLVASY YEDYAAELVV AVLRDMRMLE EAARLQRAA
Length:89
Mass (Da):10,107
Last modified:March 1, 2002 - v1
Checksum:i4CDF6D672DDDD98E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371E → G in AAN03745 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454669 mRNA. Translation: AAL58439.1.
AY163727 mRNA. Translation: AAO23114.1.
AF467809 mRNA. Translation: AAN03745.1.
AK313418 mRNA. Translation: BAG36211.1.
CH471192 Genomic DNA. Translation: EAW52147.1.
BC105033 mRNA. Translation: AAI05034.1.
BC105035 mRNA. Translation: AAI05036.1.
CCDSiCCDS10710.1.
RefSeqiNP_690865.1. NM_152901.3.
UniGeneiHs.58314.

Genome annotation databases

EnsembliENST00000302964; ENSP00000304336; ENSG00000169900.
GeneIDi260434.
KEGGihsa:260434.
UCSCiuc002ebo.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454669 mRNA. Translation: AAL58439.1.
AY163727 mRNA. Translation: AAO23114.1.
AF467809 mRNA. Translation: AAN03745.1.
AK313418 mRNA. Translation: BAG36211.1.
CH471192 Genomic DNA. Translation: EAW52147.1.
BC105033 mRNA. Translation: AAI05034.1.
BC105035 mRNA. Translation: AAI05036.1.
CCDSiCCDS10710.1.
RefSeqiNP_690865.1. NM_152901.3.
UniGeneiHs.58314.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HM2NMR-Q1-89[»]
4QOBX-ray2.70A/B1-89[»]
ProteinModelPortaliQ8WXC3.
SMRiQ8WXC3. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129281. 1 interaction.
IntActiQ8WXC3. 1 interaction.
STRINGi9606.ENSP00000304336.

Polymorphism and mutation databases

BioMutaiPYDC1.
DMDMi74730989.

Proteomic databases

PaxDbiQ8WXC3.
PRIDEiQ8WXC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302964; ENSP00000304336; ENSG00000169900.
GeneIDi260434.
KEGGihsa:260434.
UCSCiuc002ebo.4. human.

Organism-specific databases

CTDi260434.
GeneCardsiPYDC1.
HGNCiHGNC:30261. PYDC1.
MIMi615700. gene.
neXtProtiNX_Q8WXC3.
PharmGKBiPA142671111.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDCM. Eukaryota.
ENOG4111636. LUCA.
GeneTreeiENSGT00440000033973.
HOGENOMiHOG000059575.
InParanoidiQ8WXC3.
KOiK12802.
OMAiDMGMREE.
OrthoDBiEOG786H4P.
PhylomeDBiQ8WXC3.

Miscellaneous databases

EvolutionaryTraceiQ8WXC3.
GenomeRNAii260434.
NextBioi93213.
PROiQ8WXC3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WXC3.
CleanExiHS_POP1.
HS_PYDC1.
GenevisibleiQ8WXC3. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PYPAF1: a PYRIN-containing APAF1-like protein that assembles with ASC and activates NF-kB."
    Manji G.A., Wang L., Geddes B.J., Brown M., Merriam S., Al-Garawi A., Mak S., Lora J.M., Briskin M., Jurman M., Cao J., DiStefano P.S., Bertin J.
    J. Biol. Chem. 277:11570-11575(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation."
    Stehlik C., Krajewska M., Welsh K., Krajewski S., Godzik A., Reed J.C.
    Biochem. J. 373:101-113(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION, INTERACTION WITH PYCARD/ASC.
    Tissue: Heart.
  3. "Pyc1 a novel regulator of the inflammosome."
    Martinon F., Hofmann K., Tschopp J.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation."
    Dorfleutner A., Bryan N.B., Talbott S.J., Funya K.N., Rellick S.L., Reed J.C., Shi X., Rojanasakul Y., Flynn D.C., Stehlik C.
    Infect. Immun. 75:1484-1492(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PYCARD, SUBCELLULAR LOCATION.
  8. "The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-kappaB, pyrin-only protein 4."
    Porter K.A., Duffy E.B., Nyland P., Atianand M.K., Sharifi H., Harton J.A.
    Genes Immun. 15:392-403(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Structure and dynamics of ASC2, a pyrin domain-only protein that regulates inflammatory signaling."
    Natarajan A., Ghose R., Hill J.M.
    J. Biol. Chem. 281:31863-31875(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiPYDC1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXC3
Secondary accession number(s): B2R8L4, Q8NFP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.