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Protein

Pyrin domain-containing protein 1

Gene

PYDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.2 Publications

GO - Biological processi

  • innate immune response Source: HGNC
  • negative regulation of NF-kappaB transcription factor activity Source: HGNC
  • negative regulation of protein kinase activity Source: HGNC
  • negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
  • positive regulation of interleukin-1 beta secretion Source: HGNC
  • tumor necrosis factor-mediated signaling pathway Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrin domain-containing protein 1Curated
Alternative name(s):
PAAD-only protein 11 Publication
Pyrin-only protein 11 Publication
cellular POP11 Publication
Short name:
cPOP11 Publication
Gene namesi
Name:PYDC1Imported
Synonyms:ASC21 Publication, ASCI, POP11 Publication, PYC1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30261. PYDC1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HGNC
  • IkappaB kinase complex Source: HGNC
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi260434.
OpenTargetsiENSG00000169900.
PharmGKBiPA142671111.

Polymorphism and mutation databases

BioMutaiPYDC1.
DMDMi74730989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002805931 – 89Pyrin domain-containing protein 1Add BLAST89

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8WXC3.
PeptideAtlasiQ8WXC3.
PRIDEiQ8WXC3.

Expressioni

Tissue specificityi

Predominantly expressed in monocytes, macrophages and granulocytes.1 Publication

Gene expression databases

BgeeiENSG00000169900.
CleanExiHS_POP1.
HS_PYDC1.
GenevisibleiQ8WXC3. HS.

Interactioni

Subunit structurei

Interacts with PYCARD/ASC (via pyrin domain).2 Publications

Protein-protein interaction databases

BioGridi129281. 1 interactor.
IntActiQ8WXC3. 1 interactor.
STRINGi9606.ENSP00000304336.

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 13Combined sources10
Helixi17 – 27Combined sources11
Helixi41 – 45Combined sources5
Helixi49 – 60Combined sources12
Helixi62 – 75Combined sources14
Helixi79 – 88Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HM2NMR-Q1-89[»]
4QOBX-ray2.70A/B1-89[»]
ProteinModelPortaliQ8WXC3.
SMRiQ8WXC3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WXC3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 89PyrinPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Contains 1 pyrin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410JDCM. Eukaryota.
ENOG4111636. LUCA.
GeneTreeiENSGT00440000033973.
HOGENOMiHOG000059575.
InParanoidiQ8WXC3.
KOiK12802.
OMAiLRDIGMQ.
OrthoDBiEOG091G0OWO.
PhylomeDBiQ8WXC3.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTKREAILK VLENLTPEEL KKFKMKLGTV PLREGFERIP RGALGQLDIV
60 70 80
DLTDKLVASY YEDYAAELVV AVLRDMRMLE EAARLQRAA
Length:89
Mass (Da):10,107
Last modified:March 1, 2002 - v1
Checksum:i4CDF6D672DDDD98E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37E → G in AAN03745 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454669 mRNA. Translation: AAL58439.1.
AY163727 mRNA. Translation: AAO23114.1.
AF467809 mRNA. Translation: AAN03745.1.
AK313418 mRNA. Translation: BAG36211.1.
CH471192 Genomic DNA. Translation: EAW52147.1.
BC105033 mRNA. Translation: AAI05034.1.
BC105035 mRNA. Translation: AAI05036.1.
CCDSiCCDS10710.1.
RefSeqiNP_690865.1. NM_152901.3.
UniGeneiHs.58314.

Genome annotation databases

EnsembliENST00000302964; ENSP00000304336; ENSG00000169900.
GeneIDi260434.
KEGGihsa:260434.
UCSCiuc002ebo.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454669 mRNA. Translation: AAL58439.1.
AY163727 mRNA. Translation: AAO23114.1.
AF467809 mRNA. Translation: AAN03745.1.
AK313418 mRNA. Translation: BAG36211.1.
CH471192 Genomic DNA. Translation: EAW52147.1.
BC105033 mRNA. Translation: AAI05034.1.
BC105035 mRNA. Translation: AAI05036.1.
CCDSiCCDS10710.1.
RefSeqiNP_690865.1. NM_152901.3.
UniGeneiHs.58314.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HM2NMR-Q1-89[»]
4QOBX-ray2.70A/B1-89[»]
ProteinModelPortaliQ8WXC3.
SMRiQ8WXC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129281. 1 interactor.
IntActiQ8WXC3. 1 interactor.
STRINGi9606.ENSP00000304336.

Polymorphism and mutation databases

BioMutaiPYDC1.
DMDMi74730989.

Proteomic databases

PaxDbiQ8WXC3.
PeptideAtlasiQ8WXC3.
PRIDEiQ8WXC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302964; ENSP00000304336; ENSG00000169900.
GeneIDi260434.
KEGGihsa:260434.
UCSCiuc002ebo.4. human.

Organism-specific databases

CTDi260434.
DisGeNETi260434.
GeneCardsiPYDC1.
HGNCiHGNC:30261. PYDC1.
MIMi615700. gene.
neXtProtiNX_Q8WXC3.
OpenTargetsiENSG00000169900.
PharmGKBiPA142671111.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDCM. Eukaryota.
ENOG4111636. LUCA.
GeneTreeiENSGT00440000033973.
HOGENOMiHOG000059575.
InParanoidiQ8WXC3.
KOiK12802.
OMAiLRDIGMQ.
OrthoDBiEOG091G0OWO.
PhylomeDBiQ8WXC3.

Miscellaneous databases

EvolutionaryTraceiQ8WXC3.
GenomeRNAii260434.
PROiQ8WXC3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169900.
CleanExiHS_POP1.
HS_PYDC1.
GenevisibleiQ8WXC3. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYDC1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXC3
Secondary accession number(s): B2R8L4, Q8NFP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.