ID   ZN606_HUMAN             Reviewed;         792 AA.
AC   Q8WXB4; A8KAN2; Q8NE04; Q96JH5;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 179.
DE   RecName: Full=Zinc finger protein 606;
DE   AltName: Full=Zinc finger protein 328;
GN   Name=ZNF606; Synonyms=KIAA1852, ZNF328;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang S., Yuan W., Dai Q., Zhu C., Luo K., Li Y., Zeng W., Wang Y., Wu X.;
RT   "Characterization of a novel Kruppel-like zinc finger gene, ZNF328,
RT   strongly expressed in early human brain.";
RL   Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA   Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XX. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 8:85-95(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=15964554; DOI=10.1016/j.bbrc.2005.05.192;
RA   Ou Y., Wang S., Cai Z., Wang Y., Wang C., Li Y., Li F., Yuan W., Liu B.,
RA   Wu X., Liu M.;
RT   "ZNF328, a novel human zinc-finger protein, suppresses transcriptional
RT   activities of SRE and AP-1.";
RL   Biochem. Biophys. Res. Commun. 333:1034-1044(2005).
CC   -!- FUNCTION: May act as a transcriptional repressor.
CC       {ECO:0000269|PubMed:15964554}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15964554}.
CC   -!- TISSUE SPECIFICITY: Widely expressed in adult and fetal tissues.
CC       {ECO:0000269|PubMed:15964554}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB47481.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF455357; AAL58442.1; -; mRNA.
DR   EMBL; AB058755; BAB47481.1; ALT_INIT; mRNA.
DR   EMBL; AK293097; BAF85786.1; -; mRNA.
DR   EMBL; CH471135; EAW72546.1; -; Genomic_DNA.
DR   EMBL; BC037209; AAH37209.1; -; mRNA.
DR   CCDS; CCDS12968.1; -.
DR   PIR; G42075; G42075.
DR   RefSeq; NP_001334951.1; NM_001348022.1.
DR   RefSeq; NP_001334952.1; NM_001348023.1.
DR   RefSeq; NP_001334953.1; NM_001348024.1.
DR   RefSeq; NP_001334954.1; NM_001348025.1.
DR   RefSeq; NP_079303.2; NM_025027.4.
DR   AlphaFoldDB; Q8WXB4; -.
DR   SMR; Q8WXB4; -.
DR   BioGRID; 123110; 8.
DR   IntAct; Q8WXB4; 3.
DR   STRING; 9606.ENSP00000343617; -.
DR   iPTMnet; Q8WXB4; -.
DR   PhosphoSitePlus; Q8WXB4; -.
DR   SwissPalm; Q8WXB4; -.
DR   BioMuta; ZNF606; -.
DR   DMDM; 30921549; -.
DR   EPD; Q8WXB4; -.
DR   jPOST; Q8WXB4; -.
DR   MassIVE; Q8WXB4; -.
DR   PaxDb; 9606-ENSP00000343617; -.
DR   PeptideAtlas; Q8WXB4; -.
DR   ProteomicsDB; 75004; -.
DR   Antibodypedia; 19675; 141 antibodies from 21 providers.
DR   DNASU; 80095; -.
DR   Ensembl; ENST00000341164.9; ENSP00000343617.4; ENSG00000166704.13.
DR   Ensembl; ENST00000551380.7; ENSP00000446972.2; ENSG00000166704.13.
DR   GeneID; 80095; -.
DR   KEGG; hsa:80095; -.
DR   MANE-Select; ENST00000551380.7; ENSP00000446972.2; NM_001348022.3; NP_001334951.1.
DR   UCSC; uc002qqw.4; human.
DR   AGR; HGNC:25879; -.
DR   CTD; 80095; -.
DR   DisGeNET; 80095; -.
DR   GeneCards; ZNF606; -.
DR   HGNC; HGNC:25879; ZNF606.
DR   HPA; ENSG00000166704; Low tissue specificity.
DR   MIM; 613905; gene.
DR   neXtProt; NX_Q8WXB4; -.
DR   OpenTargets; ENSG00000166704; -.
DR   PharmGKB; PA134931984; -.
DR   VEuPathDB; HostDB:ENSG00000166704; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000161820; -.
DR   HOGENOM; CLU_002678_44_5_1; -.
DR   InParanoid; Q8WXB4; -.
DR   OMA; FGDHKGM; -.
DR   OrthoDB; 5247553at2759; -.
DR   PhylomeDB; Q8WXB4; -.
DR   TreeFam; TF350822; -.
DR   PathwayCommons; Q8WXB4; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q8WXB4; -.
DR   BioGRID-ORCS; 80095; 14 hits in 1175 CRISPR screens.
DR   ChiTaRS; ZNF606; human.
DR   GenomeRNAi; 80095; -.
DR   Pharos; Q8WXB4; Tdark.
DR   PRO; PR:Q8WXB4; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8WXB4; Protein.
DR   Bgee; ENSG00000166704; Expressed in secondary oocyte and 162 other cell types or tissues.
DR   ExpressionAtlas; Q8WXB4; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 16.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24379; KRAB AND ZINC FINGER DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR24379:SF116; ZINC FINGER PROTEIN 672; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 13.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 15.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 9.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
DR   Genevisible; Q8WXB4; HS.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..792
FT                   /note="Zinc finger protein 606"
FT                   /id="PRO_0000047688"
FT   DOMAIN          62..133
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         289..311
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         317..344
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         400..422
FT                   /note="C2H2-type 3; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         428..450
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         456..478
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         484..506
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         512..534
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         540..562
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         568..590
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         596..618
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         624..646
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         652..674
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         680..702
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         708..730
FT                   /note="C2H2-type 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         736..758
FT                   /note="C2H2-type 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         764..786
FT                   /note="C2H2-type 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VARIANT         141
FT                   /note="S -> G (in dbSNP:rs11673029)"
FT                   /id="VAR_052872"
FT   CONFLICT        725
FT                   /note="V -> I (in Ref. 5; AAH37209)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   792 AA;  91812 MW;  CC816EB8115443E4 CRC64;
     MAAINPWASW GALTDQSWGM TAVDPWASWA LCPQYPAWHV EGSLEEGRRA TGLPAAQVQE
     PVTFKDVAVD FTQEEWGQLD LVQRTLYRDV MLETYGHLLS VGNQIAKPEV ISLLEQGEEP
     WSVEQACPQR TCPEWVRNLE SKALIPAQSI FEEEQSHGMK LERYIWDDPW FSRLEVLGCK
     DQLEMYHMNQ STAMRQMVFM QKQVLSQRSS EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP
     DTHAQSWRCD SAIMYADKVT CENNDYDKTV YQSIQPIYPA RIQTGDNLFK CTDAVKSFNH
     IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP SFNEHPRLHV GENQYNYKEY ENIFYFSSFM
     EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH TSTYTAEKPY DYNECGTSFI WSSYLIQHKK
     THTGEKPYEC DKCGKVFRNR SALTKHERTH TGIKPYECNK CGKAFSWNSH LIVHKRIHTG
     EKPYVCNECG KSFNWNSHLI GHQRTHTGEK PFECTECGKS FSWSSHLIAH MRMHTGEKPF
     KCDECEKAFR DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH TGEKPYNCQE
     CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK PYECNKCGKS
     FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR THTGEKPYRC NECGKAFNES
     SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS LIIHQRMHSG EKRFICSECG KAFSGHSALL
     QHQRNHSEEK LN
//