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Protein

Zinc finger protein 606

Gene

ZNF606

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri289 – 311C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 344C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST28
Zinc fingeri400 – 422C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri680 – 702C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri736 – 758C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 786C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 606
Alternative name(s):
Zinc finger protein 328
Gene namesi
Name:ZNF606
Synonyms:KIAA1852, ZNF328
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000166704.11
HGNCiHGNC:25879 ZNF606
MIMi613905 gene
neXtProtiNX_Q8WXB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80095
OpenTargetsiENSG00000166704
PharmGKBiPA134931984

Polymorphism and mutation databases

BioMutaiZNF606
DMDMi30921549

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476881 – 792Zinc finger protein 606Add BLAST792

Proteomic databases

EPDiQ8WXB4
PaxDbiQ8WXB4
PeptideAtlasiQ8WXB4
PRIDEiQ8WXB4

PTM databases

iPTMnetiQ8WXB4
PhosphoSitePlusiQ8WXB4

Expressioni

Tissue specificityi

Widely expressed in adult and fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000166704
CleanExiHS_ZNF606
ExpressionAtlasiQ8WXB4 baseline and differential
GenevisibleiQ8WXB4 HS

Organism-specific databases

HPAiHPA041712
HPA043584

Interactioni

Protein-protein interaction databases

BioGridi123110, 5 interactors
STRINGi9606.ENSP00000343617

Structurei

3D structure databases

ProteinModelPortaliQ8WXB4
SMRiQ8WXB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 133KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri289 – 311C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 344C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST28
Zinc fingeri400 – 422C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri680 – 702C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri736 – 758C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 786C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144088
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8WXB4
KOiK09228
OMAiYADKVTC
OrthoDBiEOG091G02KC
PhylomeDBiQ8WXB4
TreeFamiTF350822

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequencei

Sequence statusi: Complete.

Q8WXB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAINPWASW GALTDQSWGM TAVDPWASWA LCPQYPAWHV EGSLEEGRRA
60 70 80 90 100
TGLPAAQVQE PVTFKDVAVD FTQEEWGQLD LVQRTLYRDV MLETYGHLLS
110 120 130 140 150
VGNQIAKPEV ISLLEQGEEP WSVEQACPQR TCPEWVRNLE SKALIPAQSI
160 170 180 190 200
FEEEQSHGMK LERYIWDDPW FSRLEVLGCK DQLEMYHMNQ STAMRQMVFM
210 220 230 240 250
QKQVLSQRSS EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP DTHAQSWRCD
260 270 280 290 300
SAIMYADKVT CENNDYDKTV YQSIQPIYPA RIQTGDNLFK CTDAVKSFNH
310 320 330 340 350
IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP SFNEHPRLHV GENQYNYKEY
360 370 380 390 400
ENIFYFSSFM EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH TSTYTAEKPY
410 420 430 440 450
DYNECGTSFI WSSYLIQHKK THTGEKPYEC DKCGKVFRNR SALTKHERTH
460 470 480 490 500
TGIKPYECNK CGKAFSWNSH LIVHKRIHTG EKPYVCNECG KSFNWNSHLI
510 520 530 540 550
GHQRTHTGEK PFECTECGKS FSWSSHLIAH MRMHTGEKPF KCDECEKAFR
560 570 580 590 600
DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH TGEKPYNCQE
610 620 630 640 650
CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK
660 670 680 690 700
PYECNKCGKS FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR
710 720 730 740 750
THTGEKPYRC NECGKAFNES SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS
760 770 780 790
LIIHQRMHSG EKRFICSECG KAFSGHSALL QHQRNHSEEK LN
Length:792
Mass (Da):91,812
Last modified:March 1, 2002 - v1
Checksum:iCC816EB8115443E4
GO

Sequence cautioni

The sequence BAB47481 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti725V → I in AAH37209 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052872141S → G. Corresponds to variant dbSNP:rs11673029Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455357 mRNA Translation: AAL58442.1
AB058755 mRNA Translation: BAB47481.1 Different initiation.
AK293097 mRNA Translation: BAF85786.1
CH471135 Genomic DNA Translation: EAW72546.1
BC037209 mRNA Translation: AAH37209.1
CCDSiCCDS12968.1
PIRiG42075
RefSeqiNP_001334951.1, NM_001348022.1
NP_001334952.1, NM_001348023.1
NP_001334953.1, NM_001348024.1
NP_001334954.1, NM_001348025.1
NP_079303.2, NM_025027.4
UniGeneiHs.654967

Genome annotation databases

EnsembliENST00000341164; ENSP00000343617; ENSG00000166704
GeneIDi80095
KEGGihsa:80095
UCSCiuc002qqw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN606_HUMAN
AccessioniPrimary (citable) accession number: Q8WXB4
Secondary accession number(s): A8KAN2, Q8NE04, Q96JH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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