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Q8WXB4

- ZN606_HUMAN

UniProt

Q8WXB4 - ZN606_HUMAN

Protein

Zinc finger protein 606

Gene

ZNF606

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May act as a transcriptional repressor.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri289 – 31123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 34428C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri456 – 47823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri484 – 50623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri512 – 53423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri540 – 56223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri568 – 59023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri596 – 61823C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri624 – 64623C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri652 – 67423C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri680 – 70223C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri708 – 73023C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri736 – 75823C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri764 – 78623C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 606
    Alternative name(s):
    Zinc finger protein 328
    Gene namesi
    Name:ZNF606
    Synonyms:KIAA1852, ZNF328
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:25879. ZNF606.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134931984.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 792792Zinc finger protein 606PRO_0000047688Add
    BLAST

    Proteomic databases

    PaxDbiQ8WXB4.
    PRIDEiQ8WXB4.

    PTM databases

    PhosphoSiteiQ8WXB4.

    Expressioni

    Tissue specificityi

    Widely expressed in adult and fetal tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ8WXB4.
    BgeeiQ8WXB4.
    CleanExiHS_ZNF606.
    GenevestigatoriQ8WXB4.

    Organism-specific databases

    HPAiHPA041712.

    Interactioni

    Protein-protein interaction databases

    BioGridi123110. 6 interactions.
    STRINGi9606.ENSP00000343617.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXB4.
    SMRiQ8WXB4. Positions 298-786.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 13372KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri289 – 31123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 34428C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri456 – 47823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri484 – 50623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri512 – 53423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri540 – 56223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri568 – 59023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri596 – 61823C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri624 – 64623C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri652 – 67423C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri680 – 70223C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri708 – 73023C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri736 – 75823C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri764 – 78623C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ8WXB4.
    KOiK09228.
    OMAiYADKVTC.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8WXB4.
    TreeFamiTF350822.

    Family and domain databases

    Gene3Di3.30.160.60. 17 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 15 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 16 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WXB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAINPWASW GALTDQSWGM TAVDPWASWA LCPQYPAWHV EGSLEEGRRA    50
    TGLPAAQVQE PVTFKDVAVD FTQEEWGQLD LVQRTLYRDV MLETYGHLLS 100
    VGNQIAKPEV ISLLEQGEEP WSVEQACPQR TCPEWVRNLE SKALIPAQSI 150
    FEEEQSHGMK LERYIWDDPW FSRLEVLGCK DQLEMYHMNQ STAMRQMVFM 200
    QKQVLSQRSS EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP DTHAQSWRCD 250
    SAIMYADKVT CENNDYDKTV YQSIQPIYPA RIQTGDNLFK CTDAVKSFNH 300
    IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP SFNEHPRLHV GENQYNYKEY 350
    ENIFYFSSFM EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH TSTYTAEKPY 400
    DYNECGTSFI WSSYLIQHKK THTGEKPYEC DKCGKVFRNR SALTKHERTH 450
    TGIKPYECNK CGKAFSWNSH LIVHKRIHTG EKPYVCNECG KSFNWNSHLI 500
    GHQRTHTGEK PFECTECGKS FSWSSHLIAH MRMHTGEKPF KCDECEKAFR 550
    DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH TGEKPYNCQE 600
    CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK 650
    PYECNKCGKS FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR 700
    THTGEKPYRC NECGKAFNES SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS 750
    LIIHQRMHSG EKRFICSECG KAFSGHSALL QHQRNHSEEK LN 792
    Length:792
    Mass (Da):91,812
    Last modified:March 1, 2002 - v1
    Checksum:iCC816EB8115443E4
    GO

    Sequence cautioni

    The sequence BAB47481.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti725 – 7251V → I in AAH37209. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti141 – 1411S → G.
    Corresponds to variant rs11673029 [ dbSNP | Ensembl ].
    VAR_052872

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF455357 mRNA. Translation: AAL58442.1.
    AB058755 mRNA. Translation: BAB47481.1. Different initiation.
    AK293097 mRNA. Translation: BAF85786.1.
    CH471135 Genomic DNA. Translation: EAW72546.1.
    BC037209 mRNA. Translation: AAH37209.1.
    CCDSiCCDS12968.1.
    PIRiG42075.
    RefSeqiNP_079303.2. NM_025027.3.
    XP_005259333.1. XM_005259276.1.
    UniGeneiHs.654967.

    Genome annotation databases

    EnsembliENST00000341164; ENSP00000343617; ENSG00000166704.
    GeneIDi80095.
    KEGGihsa:80095.
    UCSCiuc002qqw.3. human.

    Polymorphism databases

    DMDMi30921549.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF455357 mRNA. Translation: AAL58442.1 .
    AB058755 mRNA. Translation: BAB47481.1 . Different initiation.
    AK293097 mRNA. Translation: BAF85786.1 .
    CH471135 Genomic DNA. Translation: EAW72546.1 .
    BC037209 mRNA. Translation: AAH37209.1 .
    CCDSi CCDS12968.1.
    PIRi G42075.
    RefSeqi NP_079303.2. NM_025027.3.
    XP_005259333.1. XM_005259276.1.
    UniGenei Hs.654967.

    3D structure databases

    ProteinModelPortali Q8WXB4.
    SMRi Q8WXB4. Positions 298-786.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123110. 6 interactions.
    STRINGi 9606.ENSP00000343617.

    PTM databases

    PhosphoSitei Q8WXB4.

    Polymorphism databases

    DMDMi 30921549.

    Proteomic databases

    PaxDbi Q8WXB4.
    PRIDEi Q8WXB4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341164 ; ENSP00000343617 ; ENSG00000166704 .
    GeneIDi 80095.
    KEGGi hsa:80095.
    UCSCi uc002qqw.3. human.

    Organism-specific databases

    CTDi 80095.
    GeneCardsi GC19M058488.
    HGNCi HGNC:25879. ZNF606.
    HPAi HPA041712.
    MIMi 613905. gene.
    neXtProti NX_Q8WXB4.
    PharmGKBi PA134931984.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q8WXB4.
    KOi K09228.
    OMAi YADKVTC.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8WXB4.
    TreeFami TF350822.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 80095.
    NextBioi 70305.
    PROi Q8WXB4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WXB4.
    Bgeei Q8WXB4.
    CleanExi HS_ZNF606.
    Genevestigatori Q8WXB4.

    Family and domain databases

    Gene3Di 3.30.160.60. 17 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 15 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 16 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel Kruppel-like zinc finger gene, ZNF328, strongly expressed in early human brain."
      Wang S., Yuan W., Dai Q., Zhu C., Luo K., Li Y., Zeng W., Wang Y., Wu X.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    6. "ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1."
      Ou Y., Wang S., Cai Z., Wang Y., Wang C., Li Y., Li F., Yuan W., Liu B., Wu X., Liu M.
      Biochem. Biophys. Res. Commun. 333:1034-1044(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiZN606_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXB4
    Secondary accession number(s): A8KAN2, Q8NE04, Q96JH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3