Q8WXB4 (ZN606_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 606

Alternative name(s):
Zinc finger protein 328

Gene names

Name:	ZNF606
Synonyms:	KIAA1852, ZNF328

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	792 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a transcriptional repressor. Ref.6
Subcellular location	Nucleus Ref.6.
Tissue specificity	Widely expressed in adult and fetal tissues. Ref.6
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 16 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence BAB47481.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 792	792	Zinc finger protein 606		PRO_0000047688
Regions
	Domain	62 – 133	72	KRAB
	Zinc finger	289 – 311	23	C2H2-type 1; degenerate
	Zinc finger	317 – 344	28	C2H2-type 2; degenerate
	Zinc finger	400 – 422	23	C2H2-type 3; degenerate
	Zinc finger	428 – 450	23	C2H2-type 4
	Zinc finger	456 – 478	23	C2H2-type 5
	Zinc finger	484 – 506	23	C2H2-type 6
	Zinc finger	512 – 534	23	C2H2-type 7
	Zinc finger	540 – 562	23	C2H2-type 8
	Zinc finger	568 – 590	23	C2H2-type 9
	Zinc finger	596 – 618	23	C2H2-type 10
	Zinc finger	624 – 646	23	C2H2-type 11
	Zinc finger	652 – 674	23	C2H2-type 12
	Zinc finger	680 – 702	23	C2H2-type 13
	Zinc finger	708 – 730	23	C2H2-type 14
	Zinc finger	736 – 758	23	C2H2-type 15
	Zinc finger	764 – 786	23	C2H2-type 16
Natural variations
	Natural variant	141	1	S → G. Corresponds to variant rs11673029 [ dbSNP | Ensembl ].		VAR_052872
Experimental info
	Sequence conflict	725	1	V → I in AAH37209. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q8WXB4 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: CC816EB8115443E4	FASTA	792	91,812
	10 20 30 40 50 60 MAAINPWASW GALTDQSWGM TAVDPWASWA LCPQYPAWHV EGSLEEGRRA TGLPAAQVQE 70 80 90 100 110 120 PVTFKDVAVD FTQEEWGQLD LVQRTLYRDV MLETYGHLLS VGNQIAKPEV ISLLEQGEEP 130 140 150 160 170 180 WSVEQACPQR TCPEWVRNLE SKALIPAQSI FEEEQSHGMK LERYIWDDPW FSRLEVLGCK 190 200 210 220 230 240 DQLEMYHMNQ STAMRQMVFM QKQVLSQRSS EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP 250 260 270 280 290 300 DTHAQSWRCD SAIMYADKVT CENNDYDKTV YQSIQPIYPA RIQTGDNLFK CTDAVKSFNH 310 320 330 340 350 360 IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP SFNEHPRLHV GENQYNYKEY ENIFYFSSFM 370 380 390 400 410 420 EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH TSTYTAEKPY DYNECGTSFI WSSYLIQHKK 430 440 450 460 470 480 THTGEKPYEC DKCGKVFRNR SALTKHERTH TGIKPYECNK CGKAFSWNSH LIVHKRIHTG 490 500 510 520 530 540 EKPYVCNECG KSFNWNSHLI GHQRTHTGEK PFECTECGKS FSWSSHLIAH MRMHTGEKPF 550 560 570 580 590 600 KCDECEKAFR DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH TGEKPYNCQE 610 620 630 640 650 660 CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK PYECNKCGKS 670 680 690 700 710 720 FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR THTGEKPYRC NECGKAFNES 730 740 750 760 770 780 SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS LIIHQRMHSG EKRFICSECG KAFSGHSALL 790 QHQRNHSEEK LN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel Kruppel-like zinc finger gene, ZNF328, strongly expressed in early human brain." Wang S., Yuan W., Dai Q., Zhu C., Luo K., Li Y., Zeng W., Wang Y., Wu X. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[6]	"ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1." Ou Y., Wang S., Cai Z., Wang Y., Wang C., Li Y., Li F., Yuan W., Liu B., Wu X., Liu M. Biochem. Biophys. Res. Commun. 333:1034-1044(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF455357 mRNA. Translation: AAL58442.1. AB058755 mRNA. Translation: BAB47481.1. Different initiation. AK293097 mRNA. Translation: BAF85786.1. CH471135 Genomic DNA. Translation: EAW72546.1. BC037209 mRNA. Translation: AAH37209.1.
IPI	IPI00328220.
PIR	G42075.
RefSeq	NP_079303.2. NM_025027.3.
UniGene	Hs.654967.
3D structure databases
ProteinModelPortal	Q8WXB4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000343617.
PTM databases
PhosphoSite	Q8WXB4.
Polymorphism databases
DMDM	30921549.
Proteomic databases
PaxDb	Q8WXB4.
PRIDE	Q8WXB4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341164; ENSP00000343617; ENSG00000166704.
GeneID	80095.
KEGG	hsa:80095.
UCSC	uc002qqw.3. human.
Organism-specific databases
CTD	80095.
GeneCards	GC19M058488.
HGNC	HGNC:25879. ZNF606.
HPA	HPA041712.
MIM	613905. gene.
neXtProt	NX_Q8WXB4.
PharmGKB	PA134931984.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q8WXB4.
KO	K09228.
OMA	IEHFYKP.
OrthoDB	EOG4FJ883.
PhylomeDB	Q8WXB4.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q8WXB4.
Bgee	Q8WXB4.
CleanEx	HS_ZNF606.
Genevestigator	Q8WXB4.
GermOnline	ENSG00000166704. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 17 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 15 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 16 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80095.
NextBio	70305.
SOURCE	Search...

Entry information

Entry name

ZN606_HUMAN

Accession

Primary (citable) accession number: Q8WXB4
Secondary accession number(s): A8KAN2, Q8NE04, Q96JH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.