Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8WXB4 (ZN606_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 606
Alternative name(s):
Zinc finger protein 328
Gene names
Name:ZNF606
Synonyms:KIAA1852, ZNF328
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length792 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a transcriptional repressor. Ref.6

Subcellular location

Nucleus Ref.6.

Tissue specificity

Widely expressed in adult and fetal tissues. Ref.6

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 16 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence BAB47481.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 792792Zinc finger protein 606
PRO_0000047688

Regions

Domain62 – 13372KRAB
Zinc finger289 – 31123C2H2-type 1; degenerate
Zinc finger317 – 34428C2H2-type 2; degenerate
Zinc finger400 – 42223C2H2-type 3; degenerate
Zinc finger428 – 45023C2H2-type 4
Zinc finger456 – 47823C2H2-type 5
Zinc finger484 – 50623C2H2-type 6
Zinc finger512 – 53423C2H2-type 7
Zinc finger540 – 56223C2H2-type 8
Zinc finger568 – 59023C2H2-type 9
Zinc finger596 – 61823C2H2-type 10
Zinc finger624 – 64623C2H2-type 11
Zinc finger652 – 67423C2H2-type 12
Zinc finger680 – 70223C2H2-type 13
Zinc finger708 – 73023C2H2-type 14
Zinc finger736 – 75823C2H2-type 15
Zinc finger764 – 78623C2H2-type 16

Natural variations

Natural variant1411S → G.
Corresponds to variant rs11673029 [ dbSNP | Ensembl ].
VAR_052872

Experimental info

Sequence conflict7251V → I in AAH37209. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q8WXB4 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: CC816EB8115443E4

FASTA79291,812
        10         20         30         40         50         60 
MAAINPWASW GALTDQSWGM TAVDPWASWA LCPQYPAWHV EGSLEEGRRA TGLPAAQVQE 

        70         80         90        100        110        120 
PVTFKDVAVD FTQEEWGQLD LVQRTLYRDV MLETYGHLLS VGNQIAKPEV ISLLEQGEEP 

       130        140        150        160        170        180 
WSVEQACPQR TCPEWVRNLE SKALIPAQSI FEEEQSHGMK LERYIWDDPW FSRLEVLGCK 

       190        200        210        220        230        240 
DQLEMYHMNQ STAMRQMVFM QKQVLSQRSS EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP 

       250        260        270        280        290        300 
DTHAQSWRCD SAIMYADKVT CENNDYDKTV YQSIQPIYPA RIQTGDNLFK CTDAVKSFNH 

       310        320        330        340        350        360 
IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP SFNEHPRLHV GENQYNYKEY ENIFYFSSFM 

       370        380        390        400        410        420 
EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH TSTYTAEKPY DYNECGTSFI WSSYLIQHKK 

       430        440        450        460        470        480 
THTGEKPYEC DKCGKVFRNR SALTKHERTH TGIKPYECNK CGKAFSWNSH LIVHKRIHTG 

       490        500        510        520        530        540 
EKPYVCNECG KSFNWNSHLI GHQRTHTGEK PFECTECGKS FSWSSHLIAH MRMHTGEKPF 

       550        560        570        580        590        600 
KCDECEKAFR DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH TGEKPYNCQE 

       610        620        630        640        650        660 
CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK PYECNKCGKS 

       670        680        690        700        710        720 
FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR THTGEKPYRC NECGKAFNES 

       730        740        750        760        770        780 
SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS LIIHQRMHSG EKRFICSECG KAFSGHSALL 

       790 
QHQRNHSEEK LN 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a novel Kruppel-like zinc finger gene, ZNF328, strongly expressed in early human brain."
Wang S., Yuan W., Dai Q., Zhu C., Luo K., Li Y., Zeng W., Wang Y., Wu X.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[6]"ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1."
Ou Y., Wang S., Cai Z., Wang Y., Wang C., Li Y., Li F., Yuan W., Liu B., Wu X., Liu M.
Biochem. Biophys. Res. Commun. 333:1034-1044(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF455357 mRNA. Translation: AAL58442.1.
AB058755 mRNA. Translation: BAB47481.1. Different initiation.
AK293097 mRNA. Translation: BAF85786.1.
CH471135 Genomic DNA. Translation: EAW72546.1.
BC037209 mRNA. Translation: AAH37209.1.
CCDSCCDS12968.1.
PIRG42075.
RefSeqNP_079303.2. NM_025027.3.
XP_005259333.1. XM_005259276.1.
UniGeneHs.654967.

3D structure databases

ProteinModelPortalQ8WXB4.
SMRQ8WXB4. Positions 298-786.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123110. 6 interactions.
STRING9606.ENSP00000343617.

PTM databases

PhosphoSiteQ8WXB4.

Polymorphism databases

DMDM30921549.

Proteomic databases

PaxDbQ8WXB4.
PRIDEQ8WXB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341164; ENSP00000343617; ENSG00000166704.
GeneID80095.
KEGGhsa:80095.
UCSCuc002qqw.3. human.

Organism-specific databases

CTD80095.
GeneCardsGC19M058488.
HGNCHGNC:25879. ZNF606.
HPAHPA041712.
MIM613905. gene.
neXtProtNX_Q8WXB4.
PharmGKBPA134931984.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ8WXB4.
KOK09228.
OMAYADKVTC.
OrthoDBEOG7KSX7Q.
PhylomeDBQ8WXB4.
TreeFamTF350822.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8WXB4.
BgeeQ8WXB4.
CleanExHS_ZNF606.
GenevestigatorQ8WXB4.

Family and domain databases

Gene3D3.30.160.60. 17 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi80095.
NextBio70305.
PROQ8WXB4.
SOURCESearch...

Entry information

Entry nameZN606_HUMAN
AccessionPrimary (citable) accession number: Q8WXB4
Secondary accession number(s): A8KAN2, Q8NE04, Q96JH5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM