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Q8WXB4

- ZN606_HUMAN

UniProt

Q8WXB4 - ZN606_HUMAN

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Protein

Zinc finger protein 606

Gene

ZNF606

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri289 – 31123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 34428C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri540 – 56223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri568 – 59023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri596 – 61823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri624 – 64623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri652 – 67423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri680 – 70223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri708 – 73023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri736 – 75823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri764 – 78623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 606
Alternative name(s):
Zinc finger protein 328
Gene namesi
Name:ZNF606
Synonyms:KIAA1852, ZNF328
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25879. ZNF606.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931984.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 792792Zinc finger protein 606PRO_0000047688Add
BLAST

Proteomic databases

PaxDbiQ8WXB4.
PRIDEiQ8WXB4.

PTM databases

PhosphoSiteiQ8WXB4.

Expressioni

Tissue specificityi

Widely expressed in adult and fetal tissues.1 Publication

Gene expression databases

BgeeiQ8WXB4.
CleanExiHS_ZNF606.
ExpressionAtlasiQ8WXB4. baseline and differential.
GenevestigatoriQ8WXB4.

Organism-specific databases

HPAiHPA041712.

Interactioni

Protein-protein interaction databases

BioGridi123110. 6 interactions.
STRINGi9606.ENSP00000343617.

Structurei

3D structure databases

ProteinModelPortaliQ8WXB4.
SMRiQ8WXB4. Positions 298-786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 13372KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri289 – 31123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 34428C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri540 – 56223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri568 – 59023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri596 – 61823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri624 – 64623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri652 – 67423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri680 – 70223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri708 – 73023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri736 – 75823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri764 – 78623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120459.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8WXB4.
KOiK09228.
OMAiYADKVTC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8WXB4.
TreeFamiTF350822.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WXB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAINPWASW GALTDQSWGM TAVDPWASWA LCPQYPAWHV EGSLEEGRRA
60 70 80 90 100
TGLPAAQVQE PVTFKDVAVD FTQEEWGQLD LVQRTLYRDV MLETYGHLLS
110 120 130 140 150
VGNQIAKPEV ISLLEQGEEP WSVEQACPQR TCPEWVRNLE SKALIPAQSI
160 170 180 190 200
FEEEQSHGMK LERYIWDDPW FSRLEVLGCK DQLEMYHMNQ STAMRQMVFM
210 220 230 240 250
QKQVLSQRSS EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP DTHAQSWRCD
260 270 280 290 300
SAIMYADKVT CENNDYDKTV YQSIQPIYPA RIQTGDNLFK CTDAVKSFNH
310 320 330 340 350
IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP SFNEHPRLHV GENQYNYKEY
360 370 380 390 400
ENIFYFSSFM EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH TSTYTAEKPY
410 420 430 440 450
DYNECGTSFI WSSYLIQHKK THTGEKPYEC DKCGKVFRNR SALTKHERTH
460 470 480 490 500
TGIKPYECNK CGKAFSWNSH LIVHKRIHTG EKPYVCNECG KSFNWNSHLI
510 520 530 540 550
GHQRTHTGEK PFECTECGKS FSWSSHLIAH MRMHTGEKPF KCDECEKAFR
560 570 580 590 600
DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH TGEKPYNCQE
610 620 630 640 650
CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK
660 670 680 690 700
PYECNKCGKS FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR
710 720 730 740 750
THTGEKPYRC NECGKAFNES SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS
760 770 780 790
LIIHQRMHSG EKRFICSECG KAFSGHSALL QHQRNHSEEK LN
Length:792
Mass (Da):91,812
Last modified:March 1, 2002 - v1
Checksum:iCC816EB8115443E4
GO

Sequence cautioni

The sequence BAB47481.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti725 – 7251V → I in AAH37209. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411S → G.
Corresponds to variant rs11673029 [ dbSNP | Ensembl ].
VAR_052872

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455357 mRNA. Translation: AAL58442.1.
AB058755 mRNA. Translation: BAB47481.1. Different initiation.
AK293097 mRNA. Translation: BAF85786.1.
CH471135 Genomic DNA. Translation: EAW72546.1.
BC037209 mRNA. Translation: AAH37209.1.
CCDSiCCDS12968.1.
PIRiG42075.
RefSeqiNP_079303.2. NM_025027.3.
XP_005259333.1. XM_005259276.1.
UniGeneiHs.654967.

Genome annotation databases

EnsembliENST00000341164; ENSP00000343617; ENSG00000166704.
GeneIDi80095.
KEGGihsa:80095.
UCSCiuc002qqw.3. human.

Polymorphism databases

DMDMi30921549.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455357 mRNA. Translation: AAL58442.1 .
AB058755 mRNA. Translation: BAB47481.1 . Different initiation.
AK293097 mRNA. Translation: BAF85786.1 .
CH471135 Genomic DNA. Translation: EAW72546.1 .
BC037209 mRNA. Translation: AAH37209.1 .
CCDSi CCDS12968.1.
PIRi G42075.
RefSeqi NP_079303.2. NM_025027.3.
XP_005259333.1. XM_005259276.1.
UniGenei Hs.654967.

3D structure databases

ProteinModelPortali Q8WXB4.
SMRi Q8WXB4. Positions 298-786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123110. 6 interactions.
STRINGi 9606.ENSP00000343617.

PTM databases

PhosphoSitei Q8WXB4.

Polymorphism databases

DMDMi 30921549.

Proteomic databases

PaxDbi Q8WXB4.
PRIDEi Q8WXB4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341164 ; ENSP00000343617 ; ENSG00000166704 .
GeneIDi 80095.
KEGGi hsa:80095.
UCSCi uc002qqw.3. human.

Organism-specific databases

CTDi 80095.
GeneCardsi GC19M058488.
HGNCi HGNC:25879. ZNF606.
HPAi HPA041712.
MIMi 613905. gene.
neXtProti NX_Q8WXB4.
PharmGKBi PA134931984.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120459.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8WXB4.
KOi K09228.
OMAi YADKVTC.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q8WXB4.
TreeFami TF350822.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF606. human.
GenomeRNAii 80095.
NextBioi 70305.
PROi Q8WXB4.
SOURCEi Search...

Gene expression databases

Bgeei Q8WXB4.
CleanExi HS_ZNF606.
ExpressionAtlasi Q8WXB4. baseline and differential.
Genevestigatori Q8WXB4.

Family and domain databases

Gene3Di 3.30.160.60. 17 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel Kruppel-like zinc finger gene, ZNF328, strongly expressed in early human brain."
    Wang S., Yuan W., Dai Q., Zhu C., Luo K., Li Y., Zeng W., Wang Y., Wu X.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. "ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1."
    Ou Y., Wang S., Cai Z., Wang Y., Wang C., Li Y., Li F., Yuan W., Liu B., Wu X., Liu M.
    Biochem. Biophys. Res. Commun. 333:1034-1044(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiZN606_HUMAN
AccessioniPrimary (citable) accession number: Q8WXB4
Secondary accession number(s): A8KAN2, Q8NE04, Q96JH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3