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Q8WXA9

- SREK1_HUMAN

UniProt

Q8WXA9 - SREK1_HUMAN

Protein

Splicing regulatory glutamine/lysine-rich protein 1

Gene

SREK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 By similarity.By similarity

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. RNA splicing Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Splicing regulatory glutamine/lysine-rich protein 1
    Alternative name(s):
    Serine/arginine-rich-splicing regulatory protein 86
    Short name:
    SRrp86
    Splicing factor, arginine/serine-rich 12
    Splicing regulatory protein 508
    Short name:
    SRrp508
    Gene namesi
    Name:SREK1
    Synonyms:SFRS12, SRRP86
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:17882. SREK1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: HPA
    2. mitochondrion Source: HPA
    3. nucleus Source: HPA
    4. spliceosomal complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38255.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Splicing regulatory glutamine/lysine-rich protein 1PRO_0000081940Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei184 – 1841Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WXA9.
    PaxDbiQ8WXA9.
    PeptideAtlasiQ8WXA9.
    PRIDEiQ8WXA9.

    PTM databases

    PhosphoSiteiQ8WXA9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WXA9.
    BgeeiQ8WXA9.
    CleanExiHS_SFRS12.
    GenevestigatoriQ8WXA9.

    Organism-specific databases

    HPAiHPA037674.

    Interactioni

    Subunit structurei

    Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome By similarity. Interacts with SREK1IP1.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi126754. 60 interactions.
    IntActiQ8WXA9. 7 interactions.
    MINTiMINT-4535913.
    STRINGi9606.ENSP00000334538.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXA9.
    SMRiQ8WXA9. Positions 63-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini66 – 14277RRMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi190 – 474285Arg/Glu/Lys/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the splicing factor SR family.Curated
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG277302.
    HOVERGENiHBG079174.
    InParanoidiQ8WXA9.
    KOiK13165.
    OMAiKEHDKER.
    OrthoDBiEOG7ZD1VT.
    PhylomeDBiQ8WXA9.
    TreeFamiTF106266.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WXA9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSLMPGAGL LPIPTPNPLT TLGVSLSSLG AIPAAALDPN IATLGEIPQP    50
    PLMGNVDPSK IDEIRRTVYV GNLNSQTTTA DQLLEFFKQV GEVKFVRMAG 100
    DETQPTRFAF VEFADQNSVP RALAFNGVMF GDRPLKINHS NNAIVKPPEM 150
    TPQAAAKELE EVMKRVREAQ SFISAAIEPE SGKSNERKGG RSRSHTRSKS 200
    RSSSKSHSRR KRSQSKHRSR SHNRSRSRQK DRRRSKSPHK KRSKSRERRK 250
    SRSRSHSRDK RKDTREKIKE KERVKEKDRE KEREREKERE KEKERGKNKD 300
    RDKEREKDRE KDKEKDRERE REKEHEKDRD KEKEKEQDKE KEREKDRSKE 350
    IDEKRKKDKK SRTPPRSYNA SRRSRSSSRE RRRRRSRSSS RSPRTSKTIK 400
    RKSSRSPSPR SRNKKDKKRE KERDHISERR ERERSTSMRK SSNDRDGKEK 450
    LEKNSTSLKE KEHNKEPDSS VSKEVDDKDA PRTEENKIQH NGNCQLNEEN 500
    LSTKTEAV 508
    Length:508
    Mass (Da):59,380
    Last modified:March 1, 2002 - v1
    Checksum:i878DC088B642EC3F
    GO
    Isoform 2 (identifier: Q8WXA9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MNSGGGFGLG...LSLLAPAPTM

    Note: No experimental confirmation available.

    Show »
    Length:624
    Mass (Da):71,649
    Checksum:i86DBE20EDCF3EC6F
    GO

    Sequence cautioni

    The sequence AAH47322.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MNSGGGFGLGLGFGLTPTSV IQVTNLSSAVTSEQMRTLFS FLGEIEELRLYPPDNAPLAF SSKVCYVKFRDPSSVGVAQH LTNTVFIDRALIVVPCAEGK IPEESKALSLLAPAPTM in isoform 2. 1 PublicationVSP_008399

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF459094 mRNA. Translation: AAL67778.1.
    BC047322 mRNA. Translation: AAH47322.1. Sequence problems.
    BC067770 mRNA. Translation: AAH67770.1.
    BC112343 mRNA. Translation: AAI12344.1.
    CCDSiCCDS3991.1. [Q8WXA9-1]
    CCDS43323.1. [Q8WXA9-2]
    RefSeqiNP_001070667.1. NM_001077199.2. [Q8WXA9-2]
    NP_001257421.1. NM_001270492.1.
    NP_631907.1. NM_139168.3. [Q8WXA9-1]
    XP_005248496.1. XM_005248439.1. [Q8WXA9-1]
    UniGeneiHs.49367.

    Genome annotation databases

    EnsembliENST00000334121; ENSP00000334538; ENSG00000153914. [Q8WXA9-2]
    ENST00000380918; ENSP00000370305; ENSG00000153914. [Q8WXA9-1]
    GeneIDi140890.
    KEGGihsa:140890.
    UCSCiuc003jun.4. human. [Q8WXA9-2]
    uc003juo.4. human. [Q8WXA9-1]

    Polymorphism databases

    DMDMi37537968.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF459094 mRNA. Translation: AAL67778.1 .
    BC047322 mRNA. Translation: AAH47322.1 . Sequence problems.
    BC067770 mRNA. Translation: AAH67770.1 .
    BC112343 mRNA. Translation: AAI12344.1 .
    CCDSi CCDS3991.1. [Q8WXA9-1 ]
    CCDS43323.1. [Q8WXA9-2 ]
    RefSeqi NP_001070667.1. NM_001077199.2. [Q8WXA9-2 ]
    NP_001257421.1. NM_001270492.1.
    NP_631907.1. NM_139168.3. [Q8WXA9-1 ]
    XP_005248496.1. XM_005248439.1. [Q8WXA9-1 ]
    UniGenei Hs.49367.

    3D structure databases

    ProteinModelPortali Q8WXA9.
    SMRi Q8WXA9. Positions 63-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126754. 60 interactions.
    IntActi Q8WXA9. 7 interactions.
    MINTi MINT-4535913.
    STRINGi 9606.ENSP00000334538.

    PTM databases

    PhosphoSitei Q8WXA9.

    Polymorphism databases

    DMDMi 37537968.

    Proteomic databases

    MaxQBi Q8WXA9.
    PaxDbi Q8WXA9.
    PeptideAtlasi Q8WXA9.
    PRIDEi Q8WXA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334121 ; ENSP00000334538 ; ENSG00000153914 . [Q8WXA9-2 ]
    ENST00000380918 ; ENSP00000370305 ; ENSG00000153914 . [Q8WXA9-1 ]
    GeneIDi 140890.
    KEGGi hsa:140890.
    UCSCi uc003jun.4. human. [Q8WXA9-2 ]
    uc003juo.4. human. [Q8WXA9-1 ]

    Organism-specific databases

    CTDi 140890.
    GeneCardsi GC05P065435.
    HGNCi HGNC:17882. SREK1.
    HPAi HPA037674.
    MIMi 609268. gene.
    neXtProti NX_Q8WXA9.
    PharmGKBi PA38255.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277302.
    HOVERGENi HBG079174.
    InParanoidi Q8WXA9.
    KOi K13165.
    OMAi KEHDKER.
    OrthoDBi EOG7ZD1VT.
    PhylomeDBi Q8WXA9.
    TreeFami TF106266.

    Miscellaneous databases

    ChiTaRSi SREK1. human.
    GeneWikii SFRS12.
    GenomeRNAii 140890.
    NextBioi 84548.
    PROi Q8WXA9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WXA9.
    Bgeei Q8WXA9.
    CleanExi HS_SFRS12.
    Genevestigatori Q8WXA9.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86."
      Zhang D.L., Sun X.J., Ling L.J., Chen R.S., Ma D.L.
      Yi Chuan Xue Bao 29:377-383(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Pancreas.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Mammary gland and Testis.
    3. "Large-scale proteomic analysis of the human spliceosome."
      Rappsilber J., Ryder U., Lamond A.I., Mann M.
      Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, INTERACTION WITH THE SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
    4. "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain."
      Heese K., Fujita M., Akatsu H., Yamamoto T., Kosaka K., Nagai Y., Sawada T.
      J. Mol. Neurosci. 24:269-276(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SREK1IP1.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiSREK1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXA9
    Secondary accession number(s): A4FTW3, Q2M1J0, Q86X37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3