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Q8WXA9 (SREK1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Splicing regulatory glutamine/lysine-rich protein 1
Alternative name(s):
Serine/arginine-rich-splicing regulatory protein 86
Short name=SRrp86
Splicing factor, arginine/serine-rich 12
Splicing regulatory protein 508
Short name=SRrp508
Gene names
Name:SREK1
Synonyms:SFRS12, SRRP86
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 By similarity.

Subunit structure

Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome By similarity. Interacts with SREK1IP1. Ref.3 Ref.4

Subcellular location

Nucleus.

Sequence similarities

Belongs to the splicing factor SR family.

Contains 1 RRM (RNA recognition motif) domain.

Sequence caution

The sequence AAH47322.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WXA9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WXA9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNSGGGFGLG...LSLLAPAPTM
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Splicing regulatory glutamine/lysine-rich protein 1
PRO_0000081940

Regions

Domain66 – 14277RRM
Compositional bias190 – 474285Arg/Glu/Lys/Ser-rich

Amino acid modifications

Modified residue1841Phosphoserine Ref.5

Natural variations

Alternative sequence11M → MNSGGGFGLGLGFGLTPTSV IQVTNLSSAVTSEQMRTLFS FLGEIEELRLYPPDNAPLAF SSKVCYVKFRDPSSVGVAQH LTNTVFIDRALIVVPCAEGK IPEESKALSLLAPAPTM in isoform 2.
VSP_008399

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 878DC088B642EC3F

FASTA50859,380
        10         20         30         40         50         60 
MTSLMPGAGL LPIPTPNPLT TLGVSLSSLG AIPAAALDPN IATLGEIPQP PLMGNVDPSK 

        70         80         90        100        110        120 
IDEIRRTVYV GNLNSQTTTA DQLLEFFKQV GEVKFVRMAG DETQPTRFAF VEFADQNSVP 

       130        140        150        160        170        180 
RALAFNGVMF GDRPLKINHS NNAIVKPPEM TPQAAAKELE EVMKRVREAQ SFISAAIEPE 

       190        200        210        220        230        240 
SGKSNERKGG RSRSHTRSKS RSSSKSHSRR KRSQSKHRSR SHNRSRSRQK DRRRSKSPHK 

       250        260        270        280        290        300 
KRSKSRERRK SRSRSHSRDK RKDTREKIKE KERVKEKDRE KEREREKERE KEKERGKNKD 

       310        320        330        340        350        360 
RDKEREKDRE KDKEKDRERE REKEHEKDRD KEKEKEQDKE KEREKDRSKE IDEKRKKDKK 

       370        380        390        400        410        420 
SRTPPRSYNA SRRSRSSSRE RRRRRSRSSS RSPRTSKTIK RKSSRSPSPR SRNKKDKKRE 

       430        440        450        460        470        480 
KERDHISERR ERERSTSMRK SSNDRDGKEK LEKNSTSLKE KEHNKEPDSS VSKEVDDKDA 

       490        500 
PRTEENKIQH NGNCQLNEEN LSTKTEAV 

« Hide

Isoform 2 [UniParc].

Checksum: 86DBE20EDCF3EC6F
Show »

FASTA62471,649

References

« Hide 'large scale' references
[1]"Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86."
Zhang D.L., Sun X.J., Ling L.J., Chen R.S., Ma D.L.
Yi Chuan Xue Bao 29:377-383(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Pancreas.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Mammary gland and Testis.
[3]"Large-scale proteomic analysis of the human spliceosome."
Rappsilber J., Ryder U., Lamond A.I., Mann M.
Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, INTERACTION WITH THE SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
[4]"The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain."
Heese K., Fujita M., Akatsu H., Yamamoto T., Kosaka K., Nagai Y., Sawada T.
J. Mol. Neurosci. 24:269-276(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SREK1IP1.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF459094 mRNA. Translation: AAL67778.1.
BC047322 mRNA. Translation: AAH47322.1. Sequence problems.
BC067770 mRNA. Translation: AAH67770.1.
BC112343 mRNA. Translation: AAI12344.1.
CCDSCCDS3991.1. [Q8WXA9-1]
CCDS43323.1. [Q8WXA9-2]
RefSeqNP_001070667.1. NM_001077199.2. [Q8WXA9-2]
NP_001257421.1. NM_001270492.1.
NP_631907.1. NM_139168.3. [Q8WXA9-1]
XP_005248496.1. XM_005248439.1. [Q8WXA9-1]
UniGeneHs.49367.

3D structure databases

ProteinModelPortalQ8WXA9.
SMRQ8WXA9. Positions 63-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126754. 59 interactions.
IntActQ8WXA9. 7 interactions.
MINTMINT-4535913.
STRING9606.ENSP00000334538.

PTM databases

PhosphoSiteQ8WXA9.

Polymorphism databases

DMDM37537968.

Proteomic databases

MaxQBQ8WXA9.
PaxDbQ8WXA9.
PeptideAtlasQ8WXA9.
PRIDEQ8WXA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334121; ENSP00000334538; ENSG00000153914. [Q8WXA9-2]
ENST00000380918; ENSP00000370305; ENSG00000153914. [Q8WXA9-1]
GeneID140890.
KEGGhsa:140890.
UCSCuc003jun.4. human. [Q8WXA9-2]
uc003juo.4. human. [Q8WXA9-1]

Organism-specific databases

CTD140890.
GeneCardsGC05P065435.
HGNCHGNC:17882. SREK1.
HPAHPA037674.
MIM609268. gene.
neXtProtNX_Q8WXA9.
PharmGKBPA38255.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277302.
HOVERGENHBG079174.
InParanoidQ8WXA9.
KOK13165.
OMAKEHDKER.
OrthoDBEOG7ZD1VT.
PhylomeDBQ8WXA9.
TreeFamTF106266.

Gene expression databases

ArrayExpressQ8WXA9.
BgeeQ8WXA9.
CleanExHS_SFRS12.
GenevestigatorQ8WXA9.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SMARTSM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSREK1. human.
GeneWikiSFRS12.
GenomeRNAi140890.
NextBio84548.
PROQ8WXA9.
SOURCESearch...

Entry information

Entry nameSREK1_HUMAN
AccessionPrimary (citable) accession number: Q8WXA9
Secondary accession number(s): A4FTW3, Q2M1J0, Q86X37
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM