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Q8WXA9

- SREK1_HUMAN

UniProt

Q8WXA9 - SREK1_HUMAN

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Protein
Splicing regulatory glutamine/lysine-rich protein 1
Gene
SREK1, SFRS12, SRRP86
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 By similarity.

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. RNA splicing Source: UniProtKB-KW
  2. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing regulatory glutamine/lysine-rich protein 1
Alternative name(s):
Serine/arginine-rich-splicing regulatory protein 86
Short name:
SRrp86
Splicing factor, arginine/serine-rich 12
Splicing regulatory protein 508
Short name:
SRrp508
Gene namesi
Name:SREK1
Synonyms:SFRS12, SRRP86
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:17882. SREK1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: HPA
  2. mitochondrion Source: HPA
  3. nucleus Source: HPA
  4. spliceosomal complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38255.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Splicing regulatory glutamine/lysine-rich protein 1
PRO_0000081940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WXA9.
PaxDbiQ8WXA9.
PeptideAtlasiQ8WXA9.
PRIDEiQ8WXA9.

PTM databases

PhosphoSiteiQ8WXA9.

Expressioni

Gene expression databases

ArrayExpressiQ8WXA9.
BgeeiQ8WXA9.
CleanExiHS_SFRS12.
GenevestigatoriQ8WXA9.

Organism-specific databases

HPAiHPA037674.

Interactioni

Subunit structurei

Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome By similarity. Interacts with SREK1IP1.2 Publications

Protein-protein interaction databases

BioGridi126754. 60 interactions.
IntActiQ8WXA9. 7 interactions.
MINTiMINT-4535913.
STRINGi9606.ENSP00000334538.

Structurei

3D structure databases

ProteinModelPortaliQ8WXA9.
SMRiQ8WXA9. Positions 63-142.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 14277RRM
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi190 – 474285Arg/Glu/Lys/Ser-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG277302.
HOVERGENiHBG079174.
InParanoidiQ8WXA9.
KOiK13165.
OMAiKEHDKER.
OrthoDBiEOG7ZD1VT.
PhylomeDBiQ8WXA9.
TreeFamiTF106266.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WXA9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTSLMPGAGL LPIPTPNPLT TLGVSLSSLG AIPAAALDPN IATLGEIPQP    50
PLMGNVDPSK IDEIRRTVYV GNLNSQTTTA DQLLEFFKQV GEVKFVRMAG 100
DETQPTRFAF VEFADQNSVP RALAFNGVMF GDRPLKINHS NNAIVKPPEM 150
TPQAAAKELE EVMKRVREAQ SFISAAIEPE SGKSNERKGG RSRSHTRSKS 200
RSSSKSHSRR KRSQSKHRSR SHNRSRSRQK DRRRSKSPHK KRSKSRERRK 250
SRSRSHSRDK RKDTREKIKE KERVKEKDRE KEREREKERE KEKERGKNKD 300
RDKEREKDRE KDKEKDRERE REKEHEKDRD KEKEKEQDKE KEREKDRSKE 350
IDEKRKKDKK SRTPPRSYNA SRRSRSSSRE RRRRRSRSSS RSPRTSKTIK 400
RKSSRSPSPR SRNKKDKKRE KERDHISERR ERERSTSMRK SSNDRDGKEK 450
LEKNSTSLKE KEHNKEPDSS VSKEVDDKDA PRTEENKIQH NGNCQLNEEN 500
LSTKTEAV 508
Length:508
Mass (Da):59,380
Last modified:March 1, 2002 - v1
Checksum:i878DC088B642EC3F
GO
Isoform 2 (identifier: Q8WXA9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNSGGGFGLG...LSLLAPAPTM

Note: No experimental confirmation available.

Show »
Length:624
Mass (Da):71,649
Checksum:i86DBE20EDCF3EC6F
GO

Sequence cautioni

The sequence AAH47322.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MNSGGGFGLGLGFGLTPTSV IQVTNLSSAVTSEQMRTLFS FLGEIEELRLYPPDNAPLAF SSKVCYVKFRDPSSVGVAQH LTNTVFIDRALIVVPCAEGK IPEESKALSLLAPAPTM in isoform 2.
VSP_008399

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF459094 mRNA. Translation: AAL67778.1.
BC047322 mRNA. Translation: AAH47322.1. Sequence problems.
BC067770 mRNA. Translation: AAH67770.1.
BC112343 mRNA. Translation: AAI12344.1.
CCDSiCCDS3991.1. [Q8WXA9-1]
CCDS43323.1. [Q8WXA9-2]
RefSeqiNP_001070667.1. NM_001077199.2. [Q8WXA9-2]
NP_001257421.1. NM_001270492.1.
NP_631907.1. NM_139168.3. [Q8WXA9-1]
XP_005248496.1. XM_005248439.1. [Q8WXA9-1]
UniGeneiHs.49367.

Genome annotation databases

EnsembliENST00000334121; ENSP00000334538; ENSG00000153914. [Q8WXA9-2]
ENST00000380918; ENSP00000370305; ENSG00000153914. [Q8WXA9-1]
GeneIDi140890.
KEGGihsa:140890.
UCSCiuc003jun.4. human. [Q8WXA9-2]
uc003juo.4. human. [Q8WXA9-1]

Polymorphism databases

DMDMi37537968.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF459094 mRNA. Translation: AAL67778.1 .
BC047322 mRNA. Translation: AAH47322.1 . Sequence problems.
BC067770 mRNA. Translation: AAH67770.1 .
BC112343 mRNA. Translation: AAI12344.1 .
CCDSi CCDS3991.1. [Q8WXA9-1 ]
CCDS43323.1. [Q8WXA9-2 ]
RefSeqi NP_001070667.1. NM_001077199.2. [Q8WXA9-2 ]
NP_001257421.1. NM_001270492.1.
NP_631907.1. NM_139168.3. [Q8WXA9-1 ]
XP_005248496.1. XM_005248439.1. [Q8WXA9-1 ]
UniGenei Hs.49367.

3D structure databases

ProteinModelPortali Q8WXA9.
SMRi Q8WXA9. Positions 63-142.
ModBasei Search...

Protein-protein interaction databases

BioGridi 126754. 60 interactions.
IntActi Q8WXA9. 7 interactions.
MINTi MINT-4535913.
STRINGi 9606.ENSP00000334538.

PTM databases

PhosphoSitei Q8WXA9.

Polymorphism databases

DMDMi 37537968.

Proteomic databases

MaxQBi Q8WXA9.
PaxDbi Q8WXA9.
PeptideAtlasi Q8WXA9.
PRIDEi Q8WXA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334121 ; ENSP00000334538 ; ENSG00000153914 . [Q8WXA9-2 ]
ENST00000380918 ; ENSP00000370305 ; ENSG00000153914 . [Q8WXA9-1 ]
GeneIDi 140890.
KEGGi hsa:140890.
UCSCi uc003jun.4. human. [Q8WXA9-2 ]
uc003juo.4. human. [Q8WXA9-1 ]

Organism-specific databases

CTDi 140890.
GeneCardsi GC05P065435.
HGNCi HGNC:17882. SREK1.
HPAi HPA037674.
MIMi 609268. gene.
neXtProti NX_Q8WXA9.
PharmGKBi PA38255.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277302.
HOVERGENi HBG079174.
InParanoidi Q8WXA9.
KOi K13165.
OMAi KEHDKER.
OrthoDBi EOG7ZD1VT.
PhylomeDBi Q8WXA9.
TreeFami TF106266.

Miscellaneous databases

ChiTaRSi SREK1. human.
GeneWikii SFRS12.
GenomeRNAii 140890.
NextBioi 84548.
PROi Q8WXA9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WXA9.
Bgeei Q8WXA9.
CleanExi HS_SFRS12.
Genevestigatori Q8WXA9.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86."
    Zhang D.L., Sun X.J., Ling L.J., Chen R.S., Ma D.L.
    Yi Chuan Xue Bao 29:377-383(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary gland and Testis.
  3. "Large-scale proteomic analysis of the human spliceosome."
    Rappsilber J., Ryder U., Lamond A.I., Mann M.
    Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, INTERACTION WITH THE SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
  4. "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain."
    Heese K., Fujita M., Akatsu H., Yamamoto T., Kosaka K., Nagai Y., Sawada T.
    J. Mol. Neurosci. 24:269-276(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SREK1IP1.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSREK1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXA9
Secondary accession number(s): A4FTW3, Q2M1J0, Q86X37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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