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Protein

5-hydroxytryptamine receptor 3C

Gene

HTR3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

GO - Molecular functioni

  1. extracellular ligand-gated ion channel activity Source: InterPro

GO - Biological processi

  1. ion transmembrane transport Source: Reactome
  2. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_25387. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 3C
Short name:
5-HT3-C
Short name:
5-HT3C
Alternative name(s):
Serotonin receptor 3C
Gene namesi
Name:HTR3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:24003. HTR3C.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 248221ExtracellularSequence AnalysisAdd
BLAST
Transmembranei249 – 26921Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini270 – 28213CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei283 – 30321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini304 – 3063ExtracellularSequence Analysis
Transmembranei307 – 32923Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini330 – 42495CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei425 – 44521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini446 – 4472ExtracellularSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134925741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 4474205-hydroxytryptamine receptor 3CPRO_0000312292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi162 ↔ 176By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8WXA8.
PRIDEiQ8WXA8.

Expressioni

Tissue specificityi

Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.1 Publication

Gene expression databases

BgeeiQ8WXA8.
CleanExiHS_HTR3C.
GenevestigatoriQ8WXA8.

Interactioni

Subunit structurei

Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.1 Publication

Protein-protein interaction databases

BioGridi128062. 81 interactions.
STRINGi9606.ENSP00000322617.

Structurei

3D structure databases

ProteinModelPortaliQ8WXA8.
SMRiQ8WXA8. Positions 51-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG316889.
GeneTreeiENSGT00770000120477.
HOGENOMiHOG000241519.
HOVERGENiHBG106638.
InParanoidiQ8WXA8.
KOiK04819.
OMAiDIFIMES.
OrthoDBiEOG7XPZ5D.
PhylomeDBiQ8WXA8.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WXA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGWPARQS ALLCLTVSLL LQGRGDAFTI NCSGFDQHGV DPAVFQAVFD
60 70 80 90 100
RKAFRPFTNY SIPTRVNISF TLSAILGVDA QLQLLTSFLW MDLVWDNPFI
110 120 130 140 150
NWNPKECVGI NKLTVLAENL WLPDIFIVES MDVDQTPSGL TAYISSEGRI
160 170 180 190 200
KYDKPMRVTS ICNLDIFYFP FDQQNCTFTF SSFLYTVDSM LLGMDKEVWE
210 220 230 240 250
ITDTSRKVIQ TQGEWELLGI NKATPKMSMG NNLYDQIMFY VAIRRRPSLY
260 270 280 290 300
IINLLVPSSF LVAIDALSFY LPAESENRAP FKITLLLGYN VFLLMMNDLL
310 320 330 340 350
PASGTPLISV YFALCLSLMV VSLLETVFIT YLLHVATTQP PPMPRWLHSL
360 370 380 390 400
LLHCTSPGRC CPTAPQKGNK GLGLTLTHLP GPKEPGELAG KKLGPRETEP
410 420 430 440
DGGSGWTKTQ LMELWVQFSH AMDTLLFRLY LLFMASSILT VIVLWNT
Length:447
Mass (Da):50,220
Last modified:January 15, 2008 - v2
Checksum:iE99260743598E596
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281V → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_037552
Natural varianti163 – 1631N → K.1 Publication
Corresponds to variant rs6766410 [ dbSNP | Ensembl ].
VAR_037476
Natural varianti405 – 4051G → A.1 Publication
Corresponds to variant rs6807362 [ dbSNP | Ensembl ].
VAR_037477

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459285 mRNA. Translation: AAL66182.1.
CH471052 Genomic DNA. Translation: EAW78305.1.
BC131799 mRNA. Translation: AAI31800.1.
CCDSiCCDS3250.1.
RefSeqiNP_570126.2. NM_130770.2.
UniGeneiHs.632579.

Genome annotation databases

EnsembliENST00000318351; ENSP00000322617; ENSG00000178084.
GeneIDi170572.
KEGGihsa:170572.
UCSCiuc003fmk.3. human.

Polymorphism databases

DMDMi166198366.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459285 mRNA. Translation: AAL66182.1.
CH471052 Genomic DNA. Translation: EAW78305.1.
BC131799 mRNA. Translation: AAI31800.1.
CCDSiCCDS3250.1.
RefSeqiNP_570126.2. NM_130770.2.
UniGeneiHs.632579.

3D structure databases

ProteinModelPortaliQ8WXA8.
SMRiQ8WXA8. Positions 51-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128062. 81 interactions.
STRINGi9606.ENSP00000322617.

Chemistry

BindingDBiQ8WXA8.
ChEMBLiCHEMBL2094132.
DrugBankiDB01049. Ergoloid mesylate.
GuidetoPHARMACOLOGYi375.

Polymorphism databases

DMDMi166198366.

Proteomic databases

PaxDbiQ8WXA8.
PRIDEiQ8WXA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318351; ENSP00000322617; ENSG00000178084.
GeneIDi170572.
KEGGihsa:170572.
UCSCiuc003fmk.3. human.

Organism-specific databases

CTDi170572.
GeneCardsiGC03P183770.
HGNCiHGNC:24003. HTR3C.
MIMi610121. gene.
neXtProtiNX_Q8WXA8.
PharmGKBiPA134925741.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG316889.
GeneTreeiENSGT00770000120477.
HOGENOMiHOG000241519.
HOVERGENiHBG106638.
InParanoidiQ8WXA8.
KOiK04819.
OMAiDIFIMES.
OrthoDBiEOG7XPZ5D.
PhylomeDBiQ8WXA8.
TreeFamiTF315605.

Enzyme and pathway databases

ReactomeiREACT_25387. Ligand-gated ion channel transport.

Miscellaneous databases

GeneWikiiHTR3C.
GenomeRNAii170572.
NextBioi89041.
PROiQ8WXA8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WXA8.
CleanExiHS_HTR3C.
GenevestigatoriQ8WXA8.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E."
    Niesler B., Frank B., Kapeller J., Rappold G.A.
    Gene 310:101-111(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS LYS-163 AND ALA-405.
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E."
    Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M.
    Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-128.

Entry informationi

Entry namei5HT3C_HUMAN
AccessioniPrimary (citable) accession number: Q8WXA8
Secondary accession number(s): A2RRR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: January 7, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.