Q8WXA8 (5HT3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 3C
Short name=5-HT3-C
Short name=5-HT3C

Alternative name(s):
Serotonin receptor 3C

Gene names

Name:

HTR3C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Subunit structure	Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. Ref.4
Tissue specificity	Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney. Ref.1
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ion transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome postsynaptic membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	extracellular ligand-gated ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 447	420	5-hydroxytryptamine receptor 3C		PRO_0000312292
Regions
	Topological domain	28 – 248	221	Extracellular Potential
	Transmembrane	249 – 269	21	Helical; Name=1; Potential
	Topological domain	270 – 282	13	Cytoplasmic Potential
	Transmembrane	283 – 303	21	Helical; Name=2; Potential
	Topological domain	304 – 306	3	Extracellular Potential
	Transmembrane	307 – 329	23	Helical; Name=3; Potential
	Topological domain	330 – 424	95	Cytoplasmic Potential
	Transmembrane	425 – 445	21	Helical; Name=4; Potential
	Topological domain	446 – 447	2	Extracellular Potential
Amino acid modifications
	Disulfide bond	162 ↔ 176		By similarity
Natural variations
	Natural variant	128	1	V → M in a colorectal cancer sample; somatic mutation. Ref.5		VAR_037552
	Natural variant	163	1	N → K. Ref.1 Corresponds to variant rs6766410 [ dbSNP | Ensembl ].		VAR_037476
	Natural variant	405	1	G → A. Ref.1 Corresponds to variant rs6807362 [ dbSNP | Ensembl ].		VAR_037477

Sequences

	Sequence		Length	Mass (Da)
	Q8WXA8 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: E99260743598E596	FASTA	447	50,220
	10 20 30 40 50 60 MEGGWPARQS ALLCLTVSLL LQGRGDAFTI NCSGFDQHGV DPAVFQAVFD RKAFRPFTNY 70 80 90 100 110 120 SIPTRVNISF TLSAILGVDA QLQLLTSFLW MDLVWDNPFI NWNPKECVGI NKLTVLAENL 130 140 150 160 170 180 WLPDIFIVES MDVDQTPSGL TAYISSEGRI KYDKPMRVTS ICNLDIFYFP FDQQNCTFTF 190 200 210 220 230 240 SSFLYTVDSM LLGMDKEVWE ITDTSRKVIQ TQGEWELLGI NKATPKMSMG NNLYDQIMFY 250 260 270 280 290 300 VAIRRRPSLY IINLLVPSSF LVAIDALSFY LPAESENRAP FKITLLLGYN VFLLMMNDLL 310 320 330 340 350 360 PASGTPLISV YFALCLSLMV VSLLETVFIT YLLHVATTQP PPMPRWLHSL LLHCTSPGRC 370 380 390 400 410 420 CPTAPQKGNK GLGLTLTHLP GPKEPGELAG KKLGPRETEP DGGSGWTKTQ LMELWVQFSH 430 440 AMDTLLFRLY LLFMASSILT VIVLWNT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E." Niesler B., Frank B., Kapeller J., Rappold G.A. Gene 310:101-111(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS LYS-163 AND ALA-405. Tissue: Lung.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E." Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M. Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, SUBCELLULAR LOCATION.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-128.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF459285 mRNA. Translation: AAL66182.1. CH471052 Genomic DNA. Translation: EAW78305.1. BC131799 mRNA. Translation: AAI31800.1.
IPI	IPI00103496.
RefSeq	NP_570126.2. NM_130770.2.
UniGene	Hs.632579.
3D structure databases
ProteinModelPortal	Q8WXA8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000322617.
Polymorphism databases
DMDM	166198366.
Proteomic databases
PaxDb	Q8WXA8.
PRIDE	Q8WXA8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318351; ENSP00000322617; ENSG00000178084.
GeneID	170572.
KEGG	hsa:170572.
UCSC	uc003fmk.3. human.
Organism-specific databases
CTD	170572.
GeneCards	GC03P183770.
HGNC	HGNC:24003. HTR3C.
MIM	610121. gene.
neXtProt	NX_Q8WXA8.
PharmGKB	PA134925741.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG316889.
HOGENOM	HOG000241519.
HOVERGEN	HBG106638.
InParanoid	Q8WXA8.
KO	K04819.
OMA	WNPEECV.
OrthoDB	EOG4R5034.
PhylomeDB	Q8WXA8.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
Bgee	Q8WXA8.
CleanEx	HS_HTR3C.
Genevestigator	Q8WXA8.
Family and domain databases
Gene3D	1.20.120.370. 1 hit. 2.70.170.10. 1 hit.
InterPro	IPR027361. Acetylcholine_rcpt_TM. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q8WXA8.
ChEMBL	CHEMBL4795.
GenomeRNAi	170572.
NextBio	89041.
SOURCE	Search...

Entry information

Entry name

5HT3C_HUMAN

Accession

Primary (citable) accession number: Q8WXA8
Secondary accession number(s): A2RRR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 29, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.