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Q8WXA8 (5HT3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 3C

Short name=5-HT3-C
Short name=5-HT3C
Alternative name(s):
Serotonin receptor 3C
Gene names
Name:HTR3C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Subunit structure

Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. Ref.4

Tissue specificity

Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney. Ref.1

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionIon channel
Ligand-gated ion channel
Receptor
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transmembrane transport

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionextracellular ligand-gated ion channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 4474205-hydroxytryptamine receptor 3C
PRO_0000312292

Regions

Topological domain28 – 248221Extracellular Potential
Transmembrane249 – 26921Helical; Name=1; Potential
Topological domain270 – 28213Cytoplasmic Potential
Transmembrane283 – 30321Helical; Name=2; Potential
Topological domain304 – 3063Extracellular Potential
Transmembrane307 – 32923Helical; Name=3; Potential
Topological domain330 – 42495Cytoplasmic Potential
Transmembrane425 – 44521Helical; Name=4; Potential
Topological domain446 – 4472Extracellular Potential

Amino acid modifications

Disulfide bond162 ↔ 176 By similarity

Natural variations

Natural variant1281V → M in a colorectal cancer sample; somatic mutation. Ref.5
VAR_037552
Natural variant1631N → K. Ref.1
Corresponds to variant rs6766410 [ dbSNP | Ensembl ].
VAR_037476
Natural variant4051G → A. Ref.1
Corresponds to variant rs6807362 [ dbSNP | Ensembl ].
VAR_037477

Sequences

Sequence LengthMass (Da)Tools
Q8WXA8 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: E99260743598E596

FASTA44750,220
        10         20         30         40         50         60 
MEGGWPARQS ALLCLTVSLL LQGRGDAFTI NCSGFDQHGV DPAVFQAVFD RKAFRPFTNY 

        70         80         90        100        110        120 
SIPTRVNISF TLSAILGVDA QLQLLTSFLW MDLVWDNPFI NWNPKECVGI NKLTVLAENL 

       130        140        150        160        170        180 
WLPDIFIVES MDVDQTPSGL TAYISSEGRI KYDKPMRVTS ICNLDIFYFP FDQQNCTFTF 

       190        200        210        220        230        240 
SSFLYTVDSM LLGMDKEVWE ITDTSRKVIQ TQGEWELLGI NKATPKMSMG NNLYDQIMFY 

       250        260        270        280        290        300 
VAIRRRPSLY IINLLVPSSF LVAIDALSFY LPAESENRAP FKITLLLGYN VFLLMMNDLL 

       310        320        330        340        350        360 
PASGTPLISV YFALCLSLMV VSLLETVFIT YLLHVATTQP PPMPRWLHSL LLHCTSPGRC 

       370        380        390        400        410        420 
CPTAPQKGNK GLGLTLTHLP GPKEPGELAG KKLGPRETEP DGGSGWTKTQ LMELWVQFSH 

       430        440 
AMDTLLFRLY LLFMASSILT VIVLWNT 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E."
Niesler B., Frank B., Kapeller J., Rappold G.A.
Gene 310:101-111(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS LYS-163 AND ALA-405.
Tissue: Lung.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E."
Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M.
Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, SUBCELLULAR LOCATION.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-128.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF459285 mRNA. Translation: AAL66182.1.
CH471052 Genomic DNA. Translation: EAW78305.1.
BC131799 mRNA. Translation: AAI31800.1.
RefSeqNP_570126.2. NM_130770.2.
UniGeneHs.632579.

3D structure databases

ProteinModelPortalQ8WXA8.
SMRQ8WXA8. Positions 52-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128062. 1 interaction.
STRING9606.ENSP00000322617.

Chemistry

BindingDBQ8WXA8.
ChEMBLCHEMBL2094132.

Polymorphism databases

DMDM166198366.

Proteomic databases

PaxDbQ8WXA8.
PRIDEQ8WXA8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318351; ENSP00000322617; ENSG00000178084.
GeneID170572.
KEGGhsa:170572.
UCSCuc003fmk.3. human.

Organism-specific databases

CTD170572.
GeneCardsGC03P183770.
HGNCHGNC:24003. HTR3C.
MIM610121. gene.
neXtProtNX_Q8WXA8.
PharmGKBPA134925741.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG316889.
HOGENOMHOG000241519.
HOVERGENHBG106638.
InParanoidQ8WXA8.
KOK04819.
OMADIFIMES.
OrthoDBEOG7XPZ5D.
PhylomeDBQ8WXA8.
TreeFamTF315605.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

BgeeQ8WXA8.
CleanExHS_HTR3C.
GenevestigatorQ8WXA8.

Family and domain databases

Gene3D1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHTR3C.
GenomeRNAi170572.
NextBio89041.
PROQ8WXA8.
SOURCESearch...

Entry information

Entry name5HT3C_HUMAN
AccessionPrimary (citable) accession number: Q8WXA8
Secondary accession number(s): A2RRR5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM