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Q8WXA8

- 5HT3C_HUMAN

UniProt

Q8WXA8 - 5HT3C_HUMAN

Protein

5-hydroxytryptamine receptor 3C

Gene

HTR3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

    GO - Molecular functioni

    1. extracellular ligand-gated ion channel activity Source: InterPro

    GO - Biological processi

    1. ion transmembrane transport Source: Reactome
    2. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_25387. Ligand-gated ion channel transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 3C
    Short name:
    5-HT3-C
    Short name:
    5-HT3C
    Alternative name(s):
    Serotonin receptor 3C
    Gene namesi
    Name:HTR3C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:24003. HTR3C.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134925741.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 4474205-hydroxytryptamine receptor 3CPRO_0000312292Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi162 ↔ 176By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ8WXA8.
    PRIDEiQ8WXA8.

    Expressioni

    Tissue specificityi

    Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.1 Publication

    Gene expression databases

    BgeeiQ8WXA8.
    CleanExiHS_HTR3C.
    GenevestigatoriQ8WXA8.

    Interactioni

    Subunit structurei

    Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.1 Publication

    Protein-protein interaction databases

    BioGridi128062. 1 interaction.
    STRINGi9606.ENSP00000322617.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WXA8.
    SMRiQ8WXA8. Positions 52-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 248221ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini270 – 28213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini304 – 3063ExtracellularSequence Analysis
    Topological domaini330 – 42495CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini446 – 4472ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei249 – 26921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei307 – 32923Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521Helical; Name=4Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG316889.
    HOGENOMiHOG000241519.
    HOVERGENiHBG106638.
    InParanoidiQ8WXA8.
    KOiK04819.
    OMAiDIFIMES.
    OrthoDBiEOG7XPZ5D.
    PhylomeDBiQ8WXA8.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 1 hit.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WXA8-1 [UniParc]FASTAAdd to Basket

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    MEGGWPARQS ALLCLTVSLL LQGRGDAFTI NCSGFDQHGV DPAVFQAVFD    50
    RKAFRPFTNY SIPTRVNISF TLSAILGVDA QLQLLTSFLW MDLVWDNPFI 100
    NWNPKECVGI NKLTVLAENL WLPDIFIVES MDVDQTPSGL TAYISSEGRI 150
    KYDKPMRVTS ICNLDIFYFP FDQQNCTFTF SSFLYTVDSM LLGMDKEVWE 200
    ITDTSRKVIQ TQGEWELLGI NKATPKMSMG NNLYDQIMFY VAIRRRPSLY 250
    IINLLVPSSF LVAIDALSFY LPAESENRAP FKITLLLGYN VFLLMMNDLL 300
    PASGTPLISV YFALCLSLMV VSLLETVFIT YLLHVATTQP PPMPRWLHSL 350
    LLHCTSPGRC CPTAPQKGNK GLGLTLTHLP GPKEPGELAG KKLGPRETEP 400
    DGGSGWTKTQ LMELWVQFSH AMDTLLFRLY LLFMASSILT VIVLWNT 447
    Length:447
    Mass (Da):50,220
    Last modified:January 15, 2008 - v2
    Checksum:iE99260743598E596
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti128 – 1281V → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_037552
    Natural varianti163 – 1631N → K.1 Publication
    Corresponds to variant rs6766410 [ dbSNP | Ensembl ].
    VAR_037476
    Natural varianti405 – 4051G → A.1 Publication
    Corresponds to variant rs6807362 [ dbSNP | Ensembl ].
    VAR_037477

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF459285 mRNA. Translation: AAL66182.1.
    CH471052 Genomic DNA. Translation: EAW78305.1.
    BC131799 mRNA. Translation: AAI31800.1.
    CCDSiCCDS3250.1.
    RefSeqiNP_570126.2. NM_130770.2.
    UniGeneiHs.632579.

    Genome annotation databases

    EnsembliENST00000318351; ENSP00000322617; ENSG00000178084.
    GeneIDi170572.
    KEGGihsa:170572.
    UCSCiuc003fmk.3. human.

    Polymorphism databases

    DMDMi166198366.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF459285 mRNA. Translation: AAL66182.1 .
    CH471052 Genomic DNA. Translation: EAW78305.1 .
    BC131799 mRNA. Translation: AAI31800.1 .
    CCDSi CCDS3250.1.
    RefSeqi NP_570126.2. NM_130770.2.
    UniGenei Hs.632579.

    3D structure databases

    ProteinModelPortali Q8WXA8.
    SMRi Q8WXA8. Positions 52-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128062. 1 interaction.
    STRINGi 9606.ENSP00000322617.

    Chemistry

    BindingDBi Q8WXA8.
    ChEMBLi CHEMBL2096904.
    DrugBanki DB01049. Ergoloid mesylate.
    GuidetoPHARMACOLOGYi 375.

    Polymorphism databases

    DMDMi 166198366.

    Proteomic databases

    PaxDbi Q8WXA8.
    PRIDEi Q8WXA8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318351 ; ENSP00000322617 ; ENSG00000178084 .
    GeneIDi 170572.
    KEGGi hsa:170572.
    UCSCi uc003fmk.3. human.

    Organism-specific databases

    CTDi 170572.
    GeneCardsi GC03P183770.
    HGNCi HGNC:24003. HTR3C.
    MIMi 610121. gene.
    neXtProti NX_Q8WXA8.
    PharmGKBi PA134925741.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG316889.
    HOGENOMi HOG000241519.
    HOVERGENi HBG106638.
    InParanoidi Q8WXA8.
    KOi K04819.
    OMAi DIFIMES.
    OrthoDBi EOG7XPZ5D.
    PhylomeDBi Q8WXA8.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_25387. Ligand-gated ion channel transport.

    Miscellaneous databases

    GeneWikii HTR3C.
    GenomeRNAii 170572.
    NextBioi 89041.
    PROi Q8WXA8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WXA8.
    CleanExi HS_HTR3C.
    Genevestigatori Q8WXA8.

    Family and domain databases

    Gene3Di 1.20.120.370. 1 hit.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E."
      Niesler B., Frank B., Kapeller J., Rappold G.A.
      Gene 310:101-111(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS LYS-163 AND ALA-405.
      Tissue: Lung.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E."
      Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M.
      Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, SUBCELLULAR LOCATION.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-128.

    Entry informationi

    Entry namei5HT3C_HUMAN
    AccessioniPrimary (citable) accession number: Q8WXA8
    Secondary accession number(s): A2RRR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3