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Protein

Prostate and testis expressed protein 1

Gene

PATE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate and testis expressed protein 1
Gene namesi
Name:PATE1
Synonyms:PATE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24664. PATE1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724368.

Polymorphism and mutation databases

BioMutaiPATE1.
DMDMi74730987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 126105Prostate and testis expressed protein 1PRO_0000315325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 75Sequence analysis
Disulfide bondi51 ↔ 60Sequence analysis
Disulfide bondi67 ↔ 94Sequence analysis
Disulfide bondi98 ↔ 115Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8WXA2.
PeptideAtlasiQ8WXA2.
PRIDEiQ8WXA2.

PTM databases

iPTMnetiQ8WXA2.
PhosphoSiteiQ8WXA2.

Expressioni

Tissue specificityi

Expressed specifically in prostate cancer, normal prostate, and testis. Expressed in the epithelial cells of the prostate cancer and normal prostate tissues.1 Publication

Gene expression databases

BgeeiQ8WXA2.
GenevisibleiQ8WXA2. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
INCA1Q0VD863EBI-10277790,EBI-6509505
RELQ048643EBI-10277790,EBI-307352
SERTAD1Q53GC03EBI-10277790,EBI-2826300
TCF4P158843EBI-10277790,EBI-533224

Protein-protein interaction databases

BioGridi127747. 4 interactions.
IntActiQ8WXA2. 4 interactions.
STRINGi9606.ENSP00000307164.

Structurei

3D structure databases

ProteinModelPortaliQ8WXA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PATE family.Curated
Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5P7. Eukaryota.
ENOG41117ZB. LUCA.
GeneTreeiENSGT00390000012586.
HOGENOMiHOG000115459.
InParanoidiQ8WXA2.
OMAiCLKNCAN.
OrthoDBiEOG7ZPNNV.
PhylomeDBiQ8WXA2.
TreeFamiTF337781.

Family and domain databases

InterProiIPR029690. PATE1.
[Graphical view]
PANTHERiPTHR17571:SF35. PTHR17571:SF35. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKSLLLELP ILLCCFRALS GSLSMRNDAV NEIVAVKNNF PVIEIVQCRM
60 70 80 90 100
CHLQFPGEKC SRGRGICTAT TEEACMVGRM FKRDGNPWLT FMGCLKNCAD
110 120
VKGIRWSVYL VNFRCCRSHD LCNEDL
Length:126
Mass (Da):14,271
Last modified:March 1, 2002 - v1
Checksum:i9AD752F00D901FFE
GO
Isoform 2 (identifier: Q8WXA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-41: Missing.

Show »
Length:114
Mass (Da):12,945
Checksum:iF5FB04B0C440E925
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461V → I.
Corresponds to variant rs537916 [ dbSNP | Ensembl ].
VAR_052699
Natural varianti47 – 471Q → R.1 Publication
Corresponds to variant rs2114084 [ dbSNP | Ensembl ].
VAR_052700

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei30 – 4112Missing in isoform 2. 1 PublicationVSP_030533Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462605 mRNA. Translation: AAL68667.1.
CH471065 Genomic DNA. Translation: EAW67661.1.
BC039863 mRNA. Translation: AAH39863.1.
BC107044 mRNA. Translation: AAI07045.1.
CCDSiCCDS8464.1. [Q8WXA2-1]
RefSeqiNP_612151.1. NM_138294.2. [Q8WXA2-1]
UniGeneiHs.148565.

Genome annotation databases

EnsembliENST00000305738; ENSP00000307164; ENSG00000171053. [Q8WXA2-1]
ENST00000437148; ENSP00000396056; ENSG00000171053. [Q8WXA2-2]
GeneIDi160065.
KEGGihsa:160065.
UCSCiuc001qct.4. human. [Q8WXA2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462605 mRNA. Translation: AAL68667.1.
CH471065 Genomic DNA. Translation: EAW67661.1.
BC039863 mRNA. Translation: AAH39863.1.
BC107044 mRNA. Translation: AAI07045.1.
CCDSiCCDS8464.1. [Q8WXA2-1]
RefSeqiNP_612151.1. NM_138294.2. [Q8WXA2-1]
UniGeneiHs.148565.

3D structure databases

ProteinModelPortaliQ8WXA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127747. 4 interactions.
IntActiQ8WXA2. 4 interactions.
STRINGi9606.ENSP00000307164.

PTM databases

iPTMnetiQ8WXA2.
PhosphoSiteiQ8WXA2.

Polymorphism and mutation databases

BioMutaiPATE1.
DMDMi74730987.

Proteomic databases

PaxDbiQ8WXA2.
PeptideAtlasiQ8WXA2.
PRIDEiQ8WXA2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305738; ENSP00000307164; ENSG00000171053. [Q8WXA2-1]
ENST00000437148; ENSP00000396056; ENSG00000171053. [Q8WXA2-2]
GeneIDi160065.
KEGGihsa:160065.
UCSCiuc001qct.4. human. [Q8WXA2-1]

Organism-specific databases

CTDi160065.
GeneCardsiPATE1.
HGNCiHGNC:24664. PATE1.
MIMi606861. gene.
neXtProtiNX_Q8WXA2.
PharmGKBiPA164724368.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5P7. Eukaryota.
ENOG41117ZB. LUCA.
GeneTreeiENSGT00390000012586.
HOGENOMiHOG000115459.
InParanoidiQ8WXA2.
OMAiCLKNCAN.
OrthoDBiEOG7ZPNNV.
PhylomeDBiQ8WXA2.
TreeFamiTF337781.

Miscellaneous databases

GenomeRNAii160065.
PROiQ8WXA2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WXA2.
GenevisibleiQ8WXA2. HS.

Family and domain databases

InterProiIPR029690. PATE1.
[Graphical view]
PANTHERiPTHR17571:SF35. PTHR17571:SF35. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach."
    Bera T.K., Maitra R., Iavarone C., Salvatore G., Kumar V., Vincent J.J., Sathyanarayana B.K., Duray P., Lee B.K., Pastan I.
    Proc. Natl. Acad. Sci. U.S.A. 99:3058-3063(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-47.
    Tissue: Brain.

Entry informationi

Entry nameiPATE1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXA2
Secondary accession number(s): Q3KNX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.