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Protein

Prostate and testis expressed protein 1

Gene

PATE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate and testis expressed protein 1
Gene namesi
Name:PATE1
Synonyms:PATE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000171053.9.
HGNCiHGNC:24664. PATE1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi160065.
OpenTargetsiENSG00000171053.
PharmGKBiPA164724368.

Polymorphism and mutation databases

BioMutaiPATE1.
DMDMi74730987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031532522 – 126Prostate and testis expressed protein 1Add BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 75Sequence analysis
Disulfide bondi51 ↔ 60Sequence analysis
Disulfide bondi67 ↔ 94Sequence analysis
Disulfide bondi98 ↔ 115Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8WXA2.
PeptideAtlasiQ8WXA2.
PRIDEiQ8WXA2.

PTM databases

iPTMnetiQ8WXA2.
PhosphoSitePlusiQ8WXA2.

Expressioni

Tissue specificityi

Expressed specifically in prostate cancer, normal prostate, and testis. Expressed in the epithelial cells of the prostate cancer and normal prostate tissues.1 Publication

Gene expression databases

BgeeiENSG00000171053.
GenevisibleiQ8WXA2. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127747. 4 interactors.
IntActiQ8WXA2. 4 interactors.
STRINGi9606.ENSP00000307164.

Structurei

3D structure databases

ProteinModelPortaliQ8WXA2.
SMRiQ8WXA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 125UPAR/Ly6CuratedAdd BLAST80

Sequence similaritiesi

Belongs to the PATE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5P7. Eukaryota.
ENOG41117ZB. LUCA.
GeneTreeiENSGT00390000012586.
HOGENOMiHOG000115459.
InParanoidiQ8WXA2.
OMAiCLKNCAN.
OrthoDBiEOG091G1600.
PhylomeDBiQ8WXA2.
TreeFamiTF337781.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKSLLLELP ILLCCFRALS GSLSMRNDAV NEIVAVKNNF PVIEIVQCRM
60 70 80 90 100
CHLQFPGEKC SRGRGICTAT TEEACMVGRM FKRDGNPWLT FMGCLKNCAD
110 120
VKGIRWSVYL VNFRCCRSHD LCNEDL
Length:126
Mass (Da):14,271
Last modified:March 1, 2002 - v1
Checksum:i9AD752F00D901FFE
GO
Isoform 2 (identifier: Q8WXA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-41: Missing.

Show »
Length:114
Mass (Da):12,945
Checksum:iF5FB04B0C440E925
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05269946V → I. Corresponds to variant dbSNP:rs537916Ensembl.1
Natural variantiVAR_05270047Q → R1 PublicationCorresponds to variant dbSNP:rs2114084Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03053330 – 41Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462605 mRNA. Translation: AAL68667.1.
CH471065 Genomic DNA. Translation: EAW67661.1.
BC039863 mRNA. Translation: AAH39863.1.
BC107044 mRNA. Translation: AAI07045.1.
CCDSiCCDS8464.1. [Q8WXA2-1]
RefSeqiNP_612151.1. NM_138294.2. [Q8WXA2-1]
UniGeneiHs.148565.

Genome annotation databases

EnsembliENST00000305738; ENSP00000307164; ENSG00000171053. [Q8WXA2-1]
ENST00000437148; ENSP00000396056; ENSG00000171053. [Q8WXA2-2]
GeneIDi160065.
KEGGihsa:160065.
UCSCiuc001qct.4. human. [Q8WXA2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPATE1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXA2
Secondary accession number(s): Q3KNX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families