Q8WX93 (PALLD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Palladin

Alternative name(s):
SIH002
Sarcoma antigen NY-SAR-77

Gene names

Name:	PALLD
Synonyms:	KIAA0992
ORF Names:	CGI-151

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1383 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. Ref.10 Ref.11 Ref.18
Subunit structure	Interacts with EPS8, LASP1 and VASP By similarity. Interacts with ACTN, ARGBP2, LPP, PFN1, SPIN90, SRC and EZR. Ref.10 Ref.11 Ref.12 Ref.14 Ref.17 Ref.18
Subcellular location	Cytoplasm › cytoskeleton. Cell junction › focal adhesion. Cell projection › ruffle. Cell projection › lamellipodium. Cytoplasm › myofibril › sarcomere › Z line. Note: Localizes to stress fibers and Z lines. Ref.10 Ref.12 Ref.17 Ref.18
Tissue specificity	Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines. Ref.10
Induction	Isoform 3 is expressed de novo. Isoform 4 is up-regulated by TGFB1 during myofibroblast differentiation. Ref.15
Post-translational modification	Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines By similarity. Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility. Ref.18 Ref.25
Involvement in disease	Pancreatic cancer 1 (PNCA1) [MIM:606856]: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.19 Ref.21 Ref.22 Genetic variations in PALLD may be associated with myocardial infarction.
Sequence similarities	Belongs to the myotilin/palladin family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Caution	Was wrongly assigned as myoneurin (Ref.2).
Sequence caution	The sequence AAD34146.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAO65174.1 differs from that shown. Reason: Frameshift at positions 1150 and 1154. The sequence BAA76836.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAC04796.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell junction Cell projection Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat
Ligand	Actin-binding
PTM	Disulfide bond Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytoskeleton organization Non-traceable author statement Ref.10. Source: HGNC
Cellular_component	Z disc Inferred from electronic annotation. Source: UniProtKB-SubCell actin filament Inferred from direct assay Ref.10. Source: HGNC focal adhesion Inferred from electronic annotation. Source: UniProtKB-SubCell lamellipodium Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay Ref.10. Source: HGNC ruffle Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	muscle alpha-actinin binding Traceable author statement Ref.12. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WX93-1)

Also known as: 200-kDa;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WX93-2)

The sequence of this isoform differs from the canonical sequence as follows:
     656-879: Missing.
     1326-1383: YTQWHQQSQSTKPKKVRPSASRYAALSDQGLDIKAAFQPEANPSHLTLNTALVESEDL → YISRH

Isoform 3 (identifier: Q8WX93-3)

Also known as: 140-kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

Isoform 4 (identifier: Q8WX93-4)

Also known as: 90-kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-711: Missing.

Isoform 5 (identifier: Q8WX93-5)

The sequence of this isoform differs from the canonical sequence as follows:
     656-879: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q8WX93-6)

The sequence of this isoform differs from the canonical sequence as follows:
     500-1383: PEEICTLVIA...NTALVESEDL → PDVLYVFVRVRCHQMKIQYYNLAHLISSWLSSFL

Note: No experimental confirmation available.

Isoform 7 (identifier: Q8WX93-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-998: Missing.

Isoform 8 (identifier: Q8WX93-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.
     656-879: Missing.

Isoform 9 (identifier: Q8WX93-9)

The sequence of this isoform differs from the canonical sequence as follows:
     656-879: Missing.
     957-957: Q → QDIGSPHASVGSPLDGQK
     1327-1383: TQWHQQSQSTKPKKVRPSASRYAALSDQGLDIKAAFQPEANPSHLTLNTALVESEDL → ISRH

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1383

1383

Palladin

PRO_0000302720

Regions

Domain

271 – 360

90

Ig-like C2-type 1

Domain

440 – 539

100

Ig-like C2-type 2

Domain

1001 – 1085

85

Ig-like C2-type 3

Domain

1135 – 1226

92

Ig-like C2-type 4

Domain

1233 – 1324

92

Ig-like C2-type 5

Region

562 – 566

5

Interaction with VASP By similarity

Region

646 – 676

31

Interaction with LASP1 By similarity

Region

676 – 696

21

Interaction with ARGBP2, SPIN90 and SRC

Region

766 – 831

66

Interaction with EPS8 By similarity

Region

796 – 831

36

Interaction with ARGBP2, SPIN90, SRC and PFN1

Region

819 – 823

5

Interaction with VASP By similarity

Region

833 – 890

58

Interaction with ACTN

Region

1137 – 1226

90

Interaction with EZR

Region

1236 – 1326

91

Interaction with EZR

Compositional bias

563 – 567

5

Poly-Pro

Compositional bias

634 – 864

231

Pro-rich

Amino acid modifications

Modified residue

401

1

Phosphoserine Ref.16 Ref.23 Ref.26

Modified residue

684

1

Phosphoserine Ref.26

Modified residue

688

1

Phosphoserine Ref.26

Modified residue

893

1

Phosphoserine Ref.13 Ref.16 Ref.23 Ref.24 Ref.26 Ref.28

Modified residue

979

1

Phosphoserine Ref.23 Ref.26

Modified residue

984

1

Phosphoserine Ref.23 Ref.26

Modified residue

1101

1

Phosphoserine Ref.26

Modified residue

1104

1

Phosphoserine Ref.26 Ref.28

Modified residue

1106

1

Phosphoserine Ref.26

Modified residue

1116

1

Phosphoserine Ref.26 Ref.28

Modified residue

1118

1

Phosphoserine; by PKB/AKT1 Ref.25 Ref.26 Ref.28

Modified residue

1121

1

Phosphoserine Ref.13 Ref.26 Ref.28

Disulfide bond

292 ↔ 344

By similarity

Disulfide bond

462 ↔ 521

By similarity

Disulfide bond

1156 ↔ 1208

By similarity

Natural variations

Alternative sequence

1 – 998

998

Missing in isoform 7.

VSP_027925

Alternative sequence

1 – 711

711

Missing in isoform 4.

VSP_027926

Alternative sequence

1 – 382

382

Missing in isoform 3 and isoform 8.

VSP_027927

Alternative sequence

500 – 1383

884

PEEIC…ESEDL → PDVLYVFVRVRCHQMKIQYY NLAHLISSWLSSFL in isoform 6.

VSP_027928

Alternative sequence

656 – 879

224

Missing in isoform 2, isoform 5, isoform 8 and isoform 9.

VSP_027929

Alternative sequence

957

1

Q → QDIGSPHASVGSPLDGQK in isoform 9.

VSP_043794

Alternative sequence

1326 – 1383

58

YTQWH…ESEDL → YISRH in isoform 2.

VSP_027930

Alternative sequence

1327 – 1383

57

TQWHQ…ESEDL → ISRH in isoform 9.

VSP_043795

Natural variant

224

1

M → I.
Corresponds to variant rs7671781 [ dbSNP | Ensembl ].

VAR_034940

Natural variant

224

1

M → T. Ref.5
Corresponds to variant rs7655494 [ dbSNP | Ensembl ].

VAR_059401

Experimental info

Sequence conflict

277

1

L → P in BAC04796. Ref.5

Sequence conflict

472

1

V → D in BAC04796. Ref.5

Sequence conflict

611

1

N → S in AAL69964. Ref.2

Sequence conflict

847

1

S → G in BAA76836. Ref.3

Sequence conflict

1126

1

E → D in AAO65174. Ref.8

Sequence conflict

1146

1

V → G in AAO65174. Ref.8

Secondary structure

1

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1383

Helix Strand Turn

Details...

Beta strand

1003 – 1005

3

Beta strand

1010 – 1013

4

Beta strand

1018 – 1024

7

Beta strand

1031 – 1035

5

Beta strand

1046 – 1052

7

Beta strand

1057 – 1064

8

Turn

1067 – 1069

3

Beta strand

1074 – 1078

5

Beta strand

1084 – 1086

3

Beta strand

1090 – 1093

4

Beta strand

1136 – 1139

4

Beta strand

1143 – 1150

8

Beta strand

1155 – 1159

5

Beta strand

1165 – 1167

3

Beta strand

1169 – 1174

6

Beta strand

1179 – 1185

7

Beta strand

1191 – 1197

7

Helix

1200 – 1202

3

Beta strand

1204 – 1206

3

Beta strand

1208 – 1211

4

Beta strand

1216 – 1219

4

Beta strand

1222 – 1226

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (200-kDa) [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 2CABAE1A6FEE855F	FASTA	1,383	150,564
	10 20 30 40 50 60 MSGTSSHESF YDSLSDMQEE SKNTDFFPGL SAFLSQEEIN KSLDLARRAI ADSETEDFDS 70 80 90 100 110 120 EKEISQIFST SPASLCEHPS HKETKLGEHA SRRPQDNRST PVQPLAEKQT KSISSPVSKR 130 140 150 160 170 180 KPAMSPLLTR PSYIRSLRKA EKRGAKTPST NVKPKTPHQR KGGPQSQLCD KAANLIEELT 190 200 210 220 230 240 SIFKAAKPRN RSPNGESSSP DSGYLSPKNQ PSALLSASAS QSPMEDQGEM EREVKSPGAR 250 260 270 280 290 300 HCYQDNQDLA VPHNRKSHPQ PHSALHFPAA PRFIQKLRSQ EVAEGSRVYL ECRVTGNPTP 310 320 330 340 350 360 RVRWFCEGKE LHNTPDIQIH CEGGDLHTLI IAEAFEDDTG RYTCLATNPS GSDTTSAEVF 370 380 390 400 410 420 IEGASSTDSD SESLAFKSRA GAMPQAQKKT TSVSLTIGSS SPKTGVTTAV IQPLSVPVQQ 430 440 450 460 470 480 VHSPTSYLCR PDGTTTAYFP PVFTKELQNT AVAEGQVVVL ECRVRGAPPL QVQWFRQGSE 490 500 510 520 530 540 IQDSPDFRIL QKKPRSTAEP EEICTLVIAE TFPEDAGIFT CSARNDYGSA TSTAQLVVTS 550 560 570 580 590 600 ANTENCSYES MGESNNDHFQ HFPPPPPILE TSSLELASKK PSEIQQVNNP ELGLSRAALQ 610 620 630 640 650 660 MQFNAAERET NGVHPSRGVN GLINGKANSN KSLPTPAVLL SPTKEPPPLL AKPKLDPLKL 670 680 690 700 710 720 QQLQNQIRLE QEAGARQPPP APRSAPPSPP FPPPPAFPEL AACTPPASPE PMSALASRSA 730 740 750 760 770 780 PAMQSSGSFN YARPKQFIAA QNLGPASGHG TPASSPSSSS LPSPMSPTPR QFGRAPVPPF 790 800 810 820 830 840 AQPFGAEPEA PWGSSSPSPP PPPPPVFSPT AAFPVPDVFP LPPPPPPLPS PGQASHCSSP 850 860 870 880 890 900 ATRFGHSQTP AAFLSALLPS QPPPAAVNAL GLPKGVTPAG FPKKASRTAR IASDEEIQGT 910 920 930 940 950 960 KDAVIQDLER KLRFKEDLLN NGQPRLTYEE RMARRLLGAD SATVFNIQEP EEETANQEYK 970 980 990 1000 1010 1020 VSSCEQRLIS EIEYRLERSP VDESGDEVQY GDVPVENGMA PFFEMKLKHY KIFEGMPVTF 1030 1040 1050 1060 1070 1080 TCRVAGNPKP KIYWFKDGKQ ISPKSDHYTI QRDLDGTCSL HTTASTLDDD GNYTIMAANP 1090 1100 1110 1120 1130 1140 QGRISCTGRL MVQAVNQRGR SPRSPSGHPH VRRPRSRSRD SGDENEPIQE RFFRPHFLQA 1150 1160 1170 1180 1190 1200 PGDLTVQEGK LCRMDCKVSG LPTPDLSWQL DGKPVRPDSA HKMLVRENGV HSLIIEPVTS 1210 1220 1230 1240 1250 1260 RDAGIYTCIA TNRAGQNSFS LELVVAAKEA HKPPVFIEKL QNTGVADGYP VRLECRVLGV 1270 1280 1290 1300 1310 1320 PPPQIFWKKE NESLTHSTDR VSMHQDNHGY ICLLIQGATK EDAGWYTVSA KNEAGIVSCT 1330 1340 1350 1360 1370 1380 ARLDVYTQWH QQSQSTKPKK VRPSASRYAA LSDQGLDIKA AFQPEANPSH LTLNTALVES EDL
	Isoform 2 [UniParc]. Checksum: 11CC06FA94B4758B	FASTA	1,106	122,047
	10 20 30 40 50 60 MSGTSSHESF YDSLSDMQEE SKNTDFFPGL SAFLSQEEIN KSLDLARRAI ADSETEDFDS 70 80 90 100 110 120 EKEISQIFST SPASLCEHPS HKETKLGEHA SRRPQDNRST PVQPLAEKQT KSISSPVSKR 130 140 150 160 170 180 KPAMSPLLTR PSYIRSLRKA EKRGAKTPST NVKPKTPHQR KGGPQSQLCD KAANLIEELT 190 200 210 220 230 240 SIFKAAKPRN RSPNGESSSP DSGYLSPKNQ PSALLSASAS QSPMEDQGEM EREVKSPGAR 250 260 270 280 290 300 HCYQDNQDLA VPHNRKSHPQ PHSALHFPAA PRFIQKLRSQ EVAEGSRVYL ECRVTGNPTP 310 320 330 340 350 360 RVRWFCEGKE LHNTPDIQIH CEGGDLHTLI IAEAFEDDTG RYTCLATNPS GSDTTSAEVF 370 380 390 400 410 420 IEGASSTDSD SESLAFKSRA GAMPQAQKKT TSVSLTIGSS SPKTGVTTAV IQPLSVPVQQ 430 440 450 460 470 480 VHSPTSYLCR PDGTTTAYFP PVFTKELQNT AVAEGQVVVL ECRVRGAPPL QVQWFRQGSE 490 500 510 520 530 540 IQDSPDFRIL QKKPRSTAEP EEICTLVIAE TFPEDAGIFT CSARNDYGSA TSTAQLVVTS 550 560 570 580 590 600 ANTENCSYES MGESNNDHFQ HFPPPPPILE TSSLELASKK PSEIQQVNNP ELGLSRAALQ 610 620 630 640 650 660 MQFNAAERET NGVHPSRGVN GLINGKANSN KSLPTPAVLL SPTKEPPPLL AKPKLGFPKK 670 680 690 700 710 720 ASRTARIASD EEIQGTKDAV IQDLERKLRF KEDLLNNGQP RLTYEERMAR RLLGADSATV 730 740 750 760 770 780 FNIQEPEEET ANQEYKVSSC EQRLISEIEY RLERSPVDES GDEVQYGDVP VENGMAPFFE 790 800 810 820 830 840 MKLKHYKIFE GMPVTFTCRV AGNPKPKIYW FKDGKQISPK SDHYTIQRDL DGTCSLHTTA 850 860 870 880 890 900 STLDDDGNYT IMAANPQGRI SCTGRLMVQA VNQRGRSPRS PSGHPHVRRP RSRSRDSGDE 910 920 930 940 950 960 NEPIQERFFR PHFLQAPGDL TVQEGKLCRM DCKVSGLPTP DLSWQLDGKP VRPDSAHKML 970 980 990 1000 1010 1020 VRENGVHSLI IEPVTSRDAG IYTCIATNRA GQNSFSLELV VAAKEAHKPP VFIEKLQNTG 1030 1040 1050 1060 1070 1080 VADGYPVRLE CRVLGVPPPQ IFWKKENESL THSTDRVSMH QDNHGYICLL IQGATKEDAG 1090 1100 WYTVSAKNEA GIVSCTARLD VYISRH
	Isoform 3 (140-kDa) [UniParc]. Checksum: E1A3F96F80B40B4B	FASTA	1,001	108,632
	10 20 30 40 50 60 MPQAQKKTTS VSLTIGSSSP KTGVTTAVIQ PLSVPVQQVH SPTSYLCRPD GTTTAYFPPV 70 80 90 100 110 120 FTKELQNTAV AEGQVVVLEC RVRGAPPLQV QWFRQGSEIQ DSPDFRILQK KPRSTAEPEE 130 140 150 160 170 180 ICTLVIAETF PEDAGIFTCS ARNDYGSATS TAQLVVTSAN TENCSYESMG ESNNDHFQHF 190 200 210 220 230 240 PPPPPILETS SLELASKKPS EIQQVNNPEL GLSRAALQMQ FNAAERETNG VHPSRGVNGL 250 260 270 280 290 300 INGKANSNKS LPTPAVLLSP TKEPPPLLAK PKLDPLKLQQ LQNQIRLEQE AGARQPPPAP 310 320 330 340 350 360 RSAPPSPPFP PPPAFPELAA CTPPASPEPM SALASRSAPA MQSSGSFNYA RPKQFIAAQN 370 380 390 400 410 420 LGPASGHGTP ASSPSSSSLP SPMSPTPRQF GRAPVPPFAQ PFGAEPEAPW GSSSPSPPPP 430 440 450 460 470 480 PPPVFSPTAA FPVPDVFPLP PPPPPLPSPG QASHCSSPAT RFGHSQTPAA FLSALLPSQP 490 500 510 520 530 540 PPAAVNALGL PKGVTPAGFP KKASRTARIA SDEEIQGTKD AVIQDLERKL RFKEDLLNNG 550 560 570 580 590 600 QPRLTYEERM ARRLLGADSA TVFNIQEPEE ETANQEYKVS SCEQRLISEI EYRLERSPVD 610 620 630 640 650 660 ESGDEVQYGD VPVENGMAPF FEMKLKHYKI FEGMPVTFTC RVAGNPKPKI YWFKDGKQIS 670 680 690 700 710 720 PKSDHYTIQR DLDGTCSLHT TASTLDDDGN YTIMAANPQG RISCTGRLMV QAVNQRGRSP 730 740 750 760 770 780 RSPSGHPHVR RPRSRSRDSG DENEPIQERF FRPHFLQAPG DLTVQEGKLC RMDCKVSGLP 790 800 810 820 830 840 TPDLSWQLDG KPVRPDSAHK MLVRENGVHS LIIEPVTSRD AGIYTCIATN RAGQNSFSLE 850 860 870 880 890 900 LVVAAKEAHK PPVFIEKLQN TGVADGYPVR LECRVLGVPP PQIFWKKENE SLTHSTDRVS 910 920 930 940 950 960 MHQDNHGYIC LLIQGATKED AGWYTVSAKN EAGIVSCTAR LDVYTQWHQQ SQSTKPKKVR 970 980 990 1000 PSASRYAALS DQGLDIKAAF QPEANPSHLT LNTALVESED L
	Isoform 4 (90-kDa) [UniParc]. Checksum: 94168879EA796261	FASTA	672	73,322
	10 20 30 40 50 60 MSALASRSAP AMQSSGSFNY ARPKQFIAAQ NLGPASGHGT PASSPSSSSL PSPMSPTPRQ 70 80 90 100 110 120 FGRAPVPPFA QPFGAEPEAP WGSSSPSPPP PPPPVFSPTA AFPVPDVFPL PPPPPPLPSP 130 140 150 160 170 180 GQASHCSSPA TRFGHSQTPA AFLSALLPSQ PPPAAVNALG LPKGVTPAGF PKKASRTARI 190 200 210 220 230 240 ASDEEIQGTK DAVIQDLERK LRFKEDLLNN GQPRLTYEER MARRLLGADS ATVFNIQEPE 250 260 270 280 290 300 EETANQEYKV SSCEQRLISE IEYRLERSPV DESGDEVQYG DVPVENGMAP FFEMKLKHYK 310 320 330 340 350 360 IFEGMPVTFT CRVAGNPKPK IYWFKDGKQI SPKSDHYTIQ RDLDGTCSLH TTASTLDDDG 370 380 390 400 410 420 NYTIMAANPQ GRISCTGRLM VQAVNQRGRS PRSPSGHPHV RRPRSRSRDS GDENEPIQER 430 440 450 460 470 480 FFRPHFLQAP GDLTVQEGKL CRMDCKVSGL PTPDLSWQLD GKPVRPDSAH KMLVRENGVH 490 500 510 520 530 540 SLIIEPVTSR DAGIYTCIAT NRAGQNSFSL ELVVAAKEAH KPPVFIEKLQ NTGVADGYPV 550 560 570 580 590 600 RLECRVLGVP PPQIFWKKEN ESLTHSTDRV SMHQDNHGYI CLLIQGATKE DAGWYTVSAK 610 620 630 640 650 660 NEAGIVSCTA RLDVYTQWHQ QSQSTKPKKV RPSASRYAAL SDQGLDIKAA FQPEANPSHL 670 TLNTALVESE DL
	Isoform 5 [UniParc]. Checksum: 0B1482F9B0C36C25	FASTA	1,159	127,826
	10 20 30 40 50 60 MSGTSSHESF YDSLSDMQEE SKNTDFFPGL SAFLSQEEIN KSLDLARRAI ADSETEDFDS 70 80 90 100 110 120 EKEISQIFST SPASLCEHPS HKETKLGEHA SRRPQDNRST PVQPLAEKQT KSISSPVSKR 130 140 150 160 170 180 KPAMSPLLTR PSYIRSLRKA EKRGAKTPST NVKPKTPHQR KGGPQSQLCD KAANLIEELT 190 200 210 220 230 240 SIFKAAKPRN RSPNGESSSP DSGYLSPKNQ PSALLSASAS QSPMEDQGEM EREVKSPGAR 250 260 270 280 290 300 HCYQDNQDLA VPHNRKSHPQ PHSALHFPAA PRFIQKLRSQ EVAEGSRVYL ECRVTGNPTP 310 320 330 340 350 360 RVRWFCEGKE LHNTPDIQIH CEGGDLHTLI IAEAFEDDTG RYTCLATNPS GSDTTSAEVF 370 380 390 400 410 420 IEGASSTDSD SESLAFKSRA GAMPQAQKKT TSVSLTIGSS SPKTGVTTAV IQPLSVPVQQ 430 440 450 460 470 480 VHSPTSYLCR PDGTTTAYFP PVFTKELQNT AVAEGQVVVL ECRVRGAPPL QVQWFRQGSE 490 500 510 520 530 540 IQDSPDFRIL QKKPRSTAEP EEICTLVIAE TFPEDAGIFT CSARNDYGSA TSTAQLVVTS 550 560 570 580 590 600 ANTENCSYES MGESNNDHFQ HFPPPPPILE TSSLELASKK PSEIQQVNNP ELGLSRAALQ 610 620 630 640 650 660 MQFNAAERET NGVHPSRGVN GLINGKANSN KSLPTPAVLL SPTKEPPPLL AKPKLGFPKK 670 680 690 700 710 720 ASRTARIASD EEIQGTKDAV IQDLERKLRF KEDLLNNGQP RLTYEERMAR RLLGADSATV 730 740 750 760 770 780 FNIQEPEEET ANQEYKVSSC EQRLISEIEY RLERSPVDES GDEVQYGDVP VENGMAPFFE 790 800 810 820 830 840 MKLKHYKIFE GMPVTFTCRV AGNPKPKIYW FKDGKQISPK SDHYTIQRDL DGTCSLHTTA 850 860 870 880 890 900 STLDDDGNYT IMAANPQGRI SCTGRLMVQA VNQRGRSPRS PSGHPHVRRP RSRSRDSGDE 910 920 930 940 950 960 NEPIQERFFR PHFLQAPGDL TVQEGKLCRM DCKVSGLPTP DLSWQLDGKP VRPDSAHKML 970 980 990 1000 1010 1020 VRENGVHSLI IEPVTSRDAG IYTCIATNRA GQNSFSLELV VAAKEAHKPP VFIEKLQNTG 1030 1040 1050 1060 1070 1080 VADGYPVRLE CRVLGVPPPQ IFWKKENESL THSTDRVSMH QDNHGYICLL IQGATKEDAG 1090 1100 1110 1120 1130 1140 WYTVSAKNEA GIVSCTARLD VYTQWHQQSQ STKPKKVRPS ASRYAALSDQ GLDIKAAFQP 1150 EANPSHLTLN TALVESEDL
	Isoform 6 [UniParc]. Checksum: 608AB2AD12868576	FASTA	533	58,796
	10 20 30 40 50 60 MSGTSSHESF YDSLSDMQEE SKNTDFFPGL SAFLSQEEIN KSLDLARRAI ADSETEDFDS 70 80 90 100 110 120 EKEISQIFST SPASLCEHPS HKETKLGEHA SRRPQDNRST PVQPLAEKQT KSISSPVSKR 130 140 150 160 170 180 KPAMSPLLTR PSYIRSLRKA EKRGAKTPST NVKPKTPHQR KGGPQSQLCD KAANLIEELT 190 200 210 220 230 240 SIFKAAKPRN RSPNGESSSP DSGYLSPKNQ PSALLSASAS QSPMEDQGEM EREVKSPGAR 250 260 270 280 290 300 HCYQDNQDLA VPHNRKSHPQ PHSALHFPAA PRFIQKLRSQ EVAEGSRVYL ECRVTGNPTP 310 320 330 340 350 360 RVRWFCEGKE LHNTPDIQIH CEGGDLHTLI IAEAFEDDTG RYTCLATNPS GSDTTSAEVF 370 380 390 400 410 420 IEGASSTDSD SESLAFKSRA GAMPQAQKKT TSVSLTIGSS SPKTGVTTAV IQPLSVPVQQ 430 440 450 460 470 480 VHSPTSYLCR PDGTTTAYFP PVFTKELQNT AVAEGQVVVL ECRVRGAPPL QVQWFRQGSE 490 500 510 520 530 IQDSPDFRIL QKKPRSTAEP DVLYVFVRVR CHQMKIQYYN LAHLISSWLS SFL
	Isoform 7 [UniParc]. Checksum: 15853FB78B8E41B9	FASTA	385	42,933
	10 20 30 40 50 60 MAPFFEMKLK HYKIFEGMPV TFTCRVAGNP KPKIYWFKDG KQISPKSDHY TIQRDLDGTC 70 80 90 100 110 120 SLHTTASTLD DDGNYTIMAA NPQGRISCTG RLMVQAVNQR GRSPRSPSGH PHVRRPRSRS 130 140 150 160 170 180 RDSGDENEPI QERFFRPHFL QAPGDLTVQE GKLCRMDCKV SGLPTPDLSW QLDGKPVRPD 190 200 210 220 230 240 SAHKMLVREN GVHSLIIEPV TSRDAGIYTC IATNRAGQNS FSLELVVAAK EAHKPPVFIE 250 260 270 280 290 300 KLQNTGVADG YPVRLECRVL GVPPPQIFWK KENESLTHST DRVSMHQDNH GYICLLIQGA 310 320 330 340 350 360 TKEDAGWYTV SAKNEAGIVS CTARLDVYTQ WHQQSQSTKP KKVRPSASRY AALSDQGLDI 370 380 KAAFQPEANP SHLTLNTALV ESEDL
	Isoform 8 [UniParc]. Checksum: D0EE5BAF3028E2BB	FASTA	777	85,894
	10 20 30 40 50 60 MPQAQKKTTS VSLTIGSSSP KTGVTTAVIQ PLSVPVQQVH SPTSYLCRPD GTTTAYFPPV 70 80 90 100 110 120 FTKELQNTAV AEGQVVVLEC RVRGAPPLQV QWFRQGSEIQ DSPDFRILQK KPRSTAEPEE 130 140 150 160 170 180 ICTLVIAETF PEDAGIFTCS ARNDYGSATS TAQLVVTSAN TENCSYESMG ESNNDHFQHF 190 200 210 220 230 240 PPPPPILETS SLELASKKPS EIQQVNNPEL GLSRAALQMQ FNAAERETNG VHPSRGVNGL 250 260 270 280 290 300 INGKANSNKS LPTPAVLLSP TKEPPPLLAK PKLGFPKKAS RTARIASDEE IQGTKDAVIQ 310 320 330 340 350 360 DLERKLRFKE DLLNNGQPRL TYEERMARRL LGADSATVFN IQEPEEETAN QEYKVSSCEQ 370 380 390 400 410 420 RLISEIEYRL ERSPVDESGD EVQYGDVPVE NGMAPFFEMK LKHYKIFEGM PVTFTCRVAG 430 440 450 460 470 480 NPKPKIYWFK DGKQISPKSD HYTIQRDLDG TCSLHTTAST LDDDGNYTIM AANPQGRISC 490 500 510 520 530 540 TGRLMVQAVN QRGRSPRSPS GHPHVRRPRS RSRDSGDENE PIQERFFRPH FLQAPGDLTV 550 560 570 580 590 600 QEGKLCRMDC KVSGLPTPDL SWQLDGKPVR PDSAHKMLVR ENGVHSLIIE PVTSRDAGIY 610 620 630 640 650 660 TCIATNRAGQ NSFSLELVVA AKEAHKPPVF IEKLQNTGVA DGYPVRLECR VLGVPPPQIF 670 680 690 700 710 720 WKKENESLTH STDRVSMHQD NHGYICLLIQ GATKEDAGWY TVSAKNEAGI VSCTARLDVY 730 740 750 760 770 TQWHQQSQST KPKKVRPSAS RYAALSDQGL DIKAAFQPEA NPSHLTLNTA LVESEDL
	Isoform 9 [UniParc]. Checksum: 12D8DFEEBE3DF2B2	FASTA	1,123	123,693
	10 20 30 40 50 60 MSGTSSHESF YDSLSDMQEE SKNTDFFPGL SAFLSQEEIN KSLDLARRAI ADSETEDFDS 70 80 90 100 110 120 EKEISQIFST SPASLCEHPS HKETKLGEHA SRRPQDNRST PVQPLAEKQT KSISSPVSKR 130 140 150 160 170 180 KPAMSPLLTR PSYIRSLRKA EKRGAKTPST NVKPKTPHQR KGGPQSQLCD KAANLIEELT 190 200 210 220 230 240 SIFKAAKPRN RSPNGESSSP DSGYLSPKNQ PSALLSASAS QSPMEDQGEM EREVKSPGAR 250 260 270 280 290 300 HCYQDNQDLA VPHNRKSHPQ PHSALHFPAA PRFIQKLRSQ EVAEGSRVYL ECRVTGNPTP 310 320 330 340 350 360 RVRWFCEGKE LHNTPDIQIH CEGGDLHTLI IAEAFEDDTG RYTCLATNPS GSDTTSAEVF 370 380 390 400 410 420 IEGASSTDSD SESLAFKSRA GAMPQAQKKT TSVSLTIGSS SPKTGVTTAV IQPLSVPVQQ 430 440 450 460 470 480 VHSPTSYLCR PDGTTTAYFP PVFTKELQNT AVAEGQVVVL ECRVRGAPPL QVQWFRQGSE 490 500 510 520 530 540 IQDSPDFRIL QKKPRSTAEP EEICTLVIAE TFPEDAGIFT CSARNDYGSA TSTAQLVVTS 550 560 570 580 590 600 ANTENCSYES MGESNNDHFQ HFPPPPPILE TSSLELASKK PSEIQQVNNP ELGLSRAALQ 610 620 630 640 650 660 MQFNAAERET NGVHPSRGVN GLINGKANSN KSLPTPAVLL SPTKEPPPLL AKPKLGFPKK 670 680 690 700 710 720 ASRTARIASD EEIQGTKDAV IQDLERKLRF KEDLLNNGQP RLTYEERMAR RLLGADSATV 730 740 750 760 770 780 FNIQEPEEET ANQDIGSPHA SVGSPLDGQK EYKVSSCEQR LISEIEYRLE RSPVDESGDE 790 800 810 820 830 840 VQYGDVPVEN GMAPFFEMKL KHYKIFEGMP VTFTCRVAGN PKPKIYWFKD GKQISPKSDH 850 860 870 880 890 900 YTIQRDLDGT CSLHTTASTL DDDGNYTIMA ANPQGRISCT GRLMVQAVNQ RGRSPRSPSG 910 920 930 940 950 960 HPHVRRPRSR SRDSGDENEP IQERFFRPHF LQAPGDLTVQ EGKLCRMDCK VSGLPTPDLS 970 980 990 1000 1010 1020 WQLDGKPVRP DSAHKMLVRE NGVHSLIIEP VTSRDAGIYT CIATNRAGQN SFSLELVVAA 1030 1040 1050 1060 1070 1080 KEAHKPPVFI EKLQNTGVAD GYPVRLECRV LGVPPPQIFW KKENESLTHS TDRVSMHQDN 1090 1100 1110 1120 HGYICLLIQG ATKEDAGWYT VSAKNEAGIV SCTARLDVYI SRH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human SIH002 gene." Liu T., Zhang J., Ye M., Zhang Q., Fu G., Zhou J., Wu J., Shen Y., Yu M., Chen S., Mao M., Chen Z. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
[2]	Lockwood S.K. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[4]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-1383 (ISOFORM 6), VARIANT THR-224. Tissue: Tongue.
[6]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 874-1383 (ISOFORM 1). Tissue: Placenta.
[8]	"Immunomic analysis of human sarcoma." Lee S.-Y., Obata Y., Yoshida M., Stockert E., Williamson B., Jungbluth A.A., Chen Y.-T., Old L.J., Scanlan M.J. Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 874-1160 (ISOFORM 1).
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1188-1383 (ISOFORM 2). Tissue: Heart.
[10]	"Characterization of human palladin, a microfilament-associated protein." Mykkaenen O.-M., Groenholm M., Roenty M., Lalowski M., Salmikangas P., Suila H., Carpen O. Mol. Biol. Cell 12:3060-3073(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH EZR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]	"Molecular analysis of the interaction between palladin and alpha-actinin." Roenty M., Taivainen A., Moza M., Otey C.A., Carpen O. FEBS Lett. 566:30-34(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH ACTN.
[12]	"Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton." Roenty M., Taivainen A., Moza M., Kruh G.D., Ehler E., Carpen O. Exp. Cell Res. 310:88-98(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ARGBP2, SUBCELLULAR LOCATION.
[13]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893 AND SER-1121, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"The proline-rich protein palladin is a binding partner for profilin." Boukhelifa M., Moza M., Johansson T., Rachlin A., Parast M., Huttelmaier S., Roy P., Jockusch B.M., Carpen O., Karlsson R., Otey C.A. FEBS J. 273:26-33(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PFN1.
[15]	"Isoform-specific regulation of the actin-organizing protein Palladin during TGF-beta1-induced myofibroblast differentiation." Roenty M.J., Leivonen S.-K., Hinz B., Rachlin A., Otey C.A., Kaehaeri V.-M., Carpen O.M. J. Invest. Dermatol. 126:2387-2396(2006) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION (ISOFORMS 3 AND 4), INDUCTION.
[16]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401 AND SER-893, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration." Jin L., Kern M.J., Otey C.A., Wamhoff B.R., Somlyo A.V. Circ. Res. 100:817-825(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH LPP, SUBCELLULAR LOCATION.
[18]	"Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling." Ronty M., Taivainen A., Heiska L., Otey C., Ehler E., Song W.K., Carpen O. Exp. Cell Res. 313:2575-2585(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AND SRC, SUBCELLULAR LOCATION, PHOSPHORYLATION.
[19]	"Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism." Pogue-Geile K.L., Chen R., Bronner M.P., Crnogorac-Jurcevic T., Moyes K.W., Dowen S., Otey C.A., Crispin D.A., George R.D., Whitcomb D.C., Brentnall T.A. PLoS Med. 3:2216-2228(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN PNCA1.
[20]	"Identification of four gene variants associated with myocardial infarction." Shiffman D., Ellis S.G., Rowland C.M., Malloy M.J., Luke M.M., Iakoubova O.A., Pullinger C.R., Cassano J., Aouizerat B.E., Fenwick R.G., Reitz R.E., Catanese J.J., Leong D.U., Zellner C., Sninsky J.J., Topol E.J., Devlin J.J., Kane J.P. Am. J. Hum. Genet. 77:596-605(2005) [PubMed] [Europe PMC] [Abstract] Cited for: ASSOCIATION WITH MYOCARDIAL INFARCTION.
[21]	"The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer." Zogopoulous G., Rothenmund H., Eppel A., Ash C., Akbari M.R., Hedley D., Narod S.A., Gallinger S. Hum. Genet. 121:635-637(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN PNCA1.
[22]	"Palladin mutation causes familial pancreatic cancer: absence in European families." Slater E., Amrillaeva V., Fendrich V., Bartsch D., Earl J., Vitone L.J., Neoptolemos J.P., Greenhalf W. PLoS Med. 4:774-775(2007) [PubMed] [Europe PMC] [Abstract] Cited for: QUESTIONING OF INVOLVEMENT IN PNCA1.
[23]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401; SER-893; SER-979 AND SER-984, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[24]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[25]	"The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration." Chin Y.R., Toker A. Mol. Cell 38:333-344(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-1118.
[26]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401; SER-684; SER-688; SER-893; SER-979; SER-984; SER-1101; SER-1104; SER-1106; SER-1116; SER-1118 AND SER-1121, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[27]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[28]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893; SER-1104; SER-1116; SER-1118 AND SER-1121, MASS SPECTROMETRY.
[29]	"Expression, crystallization and preliminary X-ray studies of the immunoglobulin-like domain 3 of human palladin." Liang W., Yang H., Xue X., Huang Q., Bartlam M., Chen S. Acta Crystallogr. F 62:556-558(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1233-1324.
[30]	"Solution structure of the first and second Ig domains of human palladin." RIKEN structural genomics initiative (RSGI) Submitted (APR-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1000-1230.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF077041 mRNA. Translation: AAD27774.1.
AF464873 mRNA. Translation: AAL69964.1.
AB023209 mRNA. Translation: BAA76836.1. Different initiation.
AF151909 mRNA. Translation: AAD34146.1. Different initiation.
AK095512 mRNA. Translation: BAG53074.1.
AK096458 mRNA. Translation: BAC04796.1. Different initiation.
AC079858 Genomic DNA. No translation available.
AC079926 Genomic DNA. No translation available.
AC080188 Genomic DNA. No translation available.
AC084353 Genomic DNA. No translation available.
AC115538 Genomic DNA. No translation available.
BC013867 mRNA. Translation: AAH13867.2.
BC144666 mRNA. Translation: AAI44667.1.
AY211921 mRNA. Translation: AAO65174.1. Frameshift.
BX537391 mRNA. Translation: CAD97633.1.

IPI

IPI00166197.
IPI00292009.
IPI00383645.
IPI00855763.
IPI00856001.
IPI00856046.
IPI00856116.

PIR

T13078.

RefSeq

NP_001159580.1. NM_001166108.1.
NP_001159581.1. NM_001166109.1.
NP_001159582.1. NM_001166110.1.
NP_057165.3. NM_016081.3.

UniGene

Hs.151220.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DM2	NMR	-	A	1000-1096	[»]
2DM3	NMR	-	A	1133-1229	[»]

ProteinModelPortal

Q8WX93.

SMR

Q8WX93. Positions 269-538, 971-1369.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8WX93. 2 interactions.

Protein family/group databases

MEROPS

I43.001.

PTM databases

PhosphoSite

Q8WX93.

Polymorphism databases

DMDM

158564081.

Proteomic databases

PaxDb

Q8WX93.

PRIDE

Q8WX93.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000261509; ENSP00000261509; ENSG00000129116.
ENST00000335742; ENSP00000336735; ENSG00000129116.
ENST00000505667; ENSP00000425556; ENSG00000129116.
ENST00000507735; ENSP00000424016; ENSG00000129116.
ENST00000512127; ENSP00000426947; ENSG00000129116.

GeneID

23022.

KEGG

hsa:23022.

UCSC

uc003irw.3. human.
uc003irx.3. human.

Organism-specific databases

CTD

23022.

GeneCards

GC04P169418.

HGNC

HGNC:17068. PALLD.

MIM

606856. phenotype.
608092. gene.

neXtProt

NX_Q8WX93.

PharmGKB

PA142671205.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG136920.

HOGENOM

HOG000028074.

HOVERGEN

HBG059166.

OMA

TRPSYIR.

Gene expression databases

ArrayExpress

Q8WX93.

Bgee

Q8WX93.

Genevestigator

Q8WX93.

Family and domain databases

Gene3D

2.60.40.10. 6 hits.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view]

Pfam

PF07679. I-set. 5 hits.
[Graphical view]

SMART

SM00408. IGc2. 5 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 5 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PALLD. human.

EvolutionaryTrace

Q8WX93.

GenomeRNAi

23022.

NextBio

43970.

SOURCE

Search...

Entry information

Entry name

PALLD_HUMAN

Accession

Primary (citable) accession number: Q8WX93
Secondary accession number(s): B3KTG2 , B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 107 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.