ID   IBPL1_HUMAN             Reviewed;         278 AA.
AC   Q8WX77;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   24-JAN-2024, entry version 157.
DE   RecName: Full=Insulin-like growth factor-binding protein-like 1;
DE   AltName: Full=IGFBP-related protein 10;
DE   AltName: Full=Insulin-like growth factor-binding-related protein 4;
DE            Short=IGFBP-rP4;
DE   Flags: Precursor;
GN   Name=IGFBPL1; Synonyms=IGFBPRP4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND
RP   FUNCTION.
RC   TISSUE=Testis;
RX   PubMed=15845387; DOI=10.1016/j.bbrc.2005.03.163;
RA   Cai Z., Chen H.T., Boyle B., Rupp F., Funk W.D., Dedera D.A.;
RT   "Identification of a novel insulin-like growth factor binding protein gene
RT   homologue with tumor suppressor like properties.";
RL   Biochem. Biophys. Res. Commun. 331:261-266(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: IGF-binding proteins prolong the half-life of IGFs and have
CC       been shown to either inhibit or stimulate the growth promoting effects
CC       of the IGFs in cell culture. They alter the interaction of IGFs with
CC       their cell surface receptors (By similarity). May be a putative tumor
CC       suppressor protein. {ECO:0000250, ECO:0000269|PubMed:15845387}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15845387}.
CC   -!- TISSUE SPECIFICITY: Expressed at the highest level in both brain and
CC       testis, with lower levels in the prostate, bladder and lung.
CC       {ECO:0000269|PubMed:15845387}.
CC   -!- INDUCTION: Down-regulated in multiple tumors.
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DR   EMBL; AL135785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58251.1; -; Genomic_DNA.
DR   CCDS; CCDS35017.1; -.
DR   RefSeq; NP_001007564.1; NM_001007563.2.
DR   PDB; 7MJ6; X-ray; 1.95 A; C=14-22.
DR   PDB; 7MJ7; X-ray; 1.60 A; C=14-24.
DR   PDB; 7MJ8; X-ray; 1.79 A; C=14-25.
DR   PDB; 7MJ9; X-ray; 1.75 A; C=14-22.
DR   PDBsum; 7MJ6; -.
DR   PDBsum; 7MJ7; -.
DR   PDBsum; 7MJ8; -.
DR   PDBsum; 7MJ9; -.
DR   AlphaFoldDB; Q8WX77; -.
DR   SMR; Q8WX77; -.
DR   BioGRID; 131417; 26.
DR   STRING; 9606.ENSP00000366923; -.
DR   GlyCosmos; Q8WX77; 1 site, No reported glycans.
DR   GlyGen; Q8WX77; 3 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; Q8WX77; -.
DR   PhosphoSitePlus; Q8WX77; -.
DR   BioMuta; IGFBPL1; -.
DR   DMDM; 74751604; -.
DR   EPD; Q8WX77; -.
DR   MassIVE; Q8WX77; -.
DR   PaxDb; 9606-ENSP00000366923; -.
DR   PeptideAtlas; Q8WX77; -.
DR   ProteomicsDB; 74977; -.
DR   Antibodypedia; 62957; 74 antibodies from 16 providers.
DR   DNASU; 347252; -.
DR   Ensembl; ENST00000377694.2; ENSP00000366923.1; ENSG00000137142.5.
DR   GeneID; 347252; -.
DR   KEGG; hsa:347252; -.
DR   MANE-Select; ENST00000377694.2; ENSP00000366923.1; NM_001007563.3; NP_001007564.1.
DR   UCSC; uc004aaz.4; human.
DR   AGR; HGNC:20081; -.
DR   CTD; 347252; -.
DR   DisGeNET; 347252; -.
DR   GeneCards; IGFBPL1; -.
DR   HGNC; HGNC:20081; IGFBPL1.
DR   HPA; ENSG00000137142; Tissue enriched (thyroid).
DR   MIM; 610413; gene.
DR   neXtProt; NX_Q8WX77; -.
DR   OpenTargets; ENSG00000137142; -.
DR   PharmGKB; PA134937275; -.
DR   VEuPathDB; HostDB:ENSG00000137142; -.
DR   eggNOG; ENOG502QSKF; Eukaryota.
DR   GeneTree; ENSGT00530000063555; -.
DR   HOGENOM; CLU_075590_0_1_1; -.
DR   InParanoid; Q8WX77; -.
DR   OMA; WRKVTRS; -.
DR   OrthoDB; 3019991at2759; -.
DR   PhylomeDB; Q8WX77; -.
DR   TreeFam; TF331645; -.
DR   PathwayCommons; Q8WX77; -.
DR   SignaLink; Q8WX77; -.
DR   BioGRID-ORCS; 347252; 30 hits in 1138 CRISPR screens.
DR   ChiTaRS; IGFBPL1; human.
DR   GenomeRNAi; 347252; -.
DR   Pharos; Q8WX77; Tbio.
DR   PRO; PR:Q8WX77; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8WX77; Protein.
DR   Bgee; ENSG00000137142; Expressed in ganglionic eminence and 100 other cell types or tissues.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR   GO; GO:0071228; P:cellular response to tumor cell; IEP:UniProtKB.
DR   GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR   GO; GO:0009966; P:regulation of signal transduction; IBA:GO_Central.
DR   CDD; cd00096; Ig; 1.
DR   CDD; cd00104; KAZAL_FS; 1.
DR   Gene3D; 3.30.60.30; -; 1.
DR   Gene3D; 4.10.40.20; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000867; IGFBP-like.
DR   InterPro; IPR011390; IGFBP_rP_mac25.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   PANTHER; PTHR14186; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14186:SF16; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-LIKE 1; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00219; IGFBP; 1.
DR   Pfam; PF07648; Kazal_2; 1.
DR   PIRSF; PIRSF018239; IGFBP_rP_mac25; 1.
DR   SMART; SM00121; IB; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51323; IGFBP_N_2; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..278
FT                   /note="Insulin-like growth factor-binding protein-like 1"
FT                   /id="PRO_0000297687"
FT   DOMAIN          34..109
FT                   /note="IGFBP N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT   DOMAIN          95..153
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DOMAIN          155..259
FT                   /note="Ig-like C2-type"
FT   CARBOHYD        166
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        38..63
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT   DISULFID        41..65
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT   DISULFID        46..66
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT   DISULFID        52..69
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT   DISULFID        77..91
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT   DISULFID        85..106
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT   DISULFID        115..151
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        176..243
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   278 AA;  29005 MW;  C159031F05739B6F CRC64;
     MPRLSLLLPL LLLLLLPLLP PLSPSLGIRD VGGRRPKCGP CRPEGCPAPA PCPAPGISAL
     DECGCCARCL GAEGASCGGR AGGRCGPGLV CASQAAGAAP EGTGLCVCAQ RGTVCGSDGR
     SYPSVCALRL RARHTPRAHP GHLHKARDGP CEFAPVVVVP PRSVHNVTGA QVGLSCEVRA
     VPTPVITWRK VTKSPEGTQA LEELPGDHVN IAVQVRGGPS DHEATAWILI NPLRKEDEGV
     YQCHAANMVG EAESHSTVTV LDLSKYRSFH FPAPDDRM
//