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Protein

Insulin-like growth factor-binding protein-like 1

Gene

IGFBPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to tumor cell Source: UniProtKB
  • regulation of cell growth Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein-like 1
Alternative name(s):
IGFBP-related protein 10
Insulin-like growth factor-binding-related protein 4
Short name:
IGFBP-rP4
Gene namesi
Name:IGFBPL1
Synonyms:IGFBPRP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000137142.4
HGNCiHGNC:20081 IGFBPL1
MIMi610413 gene
neXtProtiNX_Q8WX77

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi347252
OpenTargetsiENSG00000137142
PharmGKBiPA134937275

Polymorphism and mutation databases

DMDMi74751604

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000029768726 – 278Insulin-like growth factor-binding protein-like 1Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi115 ↔ 151PROSITE-ProRule annotation
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi176 ↔ 243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8WX77
PaxDbiQ8WX77
PeptideAtlasiQ8WX77
PRIDEiQ8WX77

PTM databases

iPTMnetiQ8WX77
PhosphoSitePlusiQ8WX77

Expressioni

Tissue specificityi

Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.1 Publication

Inductioni

Down-regulated in multiple tumors.

Gene expression databases

BgeeiENSG00000137142
CleanExiHS_IGFBPL1

Organism-specific databases

HPAiHPA051354

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366923

Structurei

3D structure databases

ProteinModelPortaliQ8WX77
SMRiQ8WX77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 109IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST76
Domaini95 – 153Kazal-likePROSITE-ProRule annotationAdd BLAST59
Domaini155 – 259Ig-like C2-typeAdd BLAST105

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IJPX Eukaryota
ENOG4111QG6 LUCA
GeneTreeiENSGT00530000063555
HOGENOMiHOG000261684
HOVERGENiHBG031621
InParanoidiQ8WX77
OMAiRDECGCC
OrthoDBiEOG091G0QK5
PhylomeDBiQ8WX77
TreeFamiTF331645

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR000867 IGFBP-like
IPR011390 IGFBP_rP_mac25
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PANTHERiPTHR14186 PTHR14186, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00219 IGFBP, 1 hit
PF07648 Kazal_2, 1 hit
PIRSFiPIRSF018239 IGFBP_rP_mac25, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WX77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLSLLLPL LLLLLLPLLP PLSPSLGIRD VGGRRPKCGP CRPEGCPAPA
60 70 80 90 100
PCPAPGISAL DECGCCARCL GAEGASCGGR AGGRCGPGLV CASQAAGAAP
110 120 130 140 150
EGTGLCVCAQ RGTVCGSDGR SYPSVCALRL RARHTPRAHP GHLHKARDGP
160 170 180 190 200
CEFAPVVVVP PRSVHNVTGA QVGLSCEVRA VPTPVITWRK VTKSPEGTQA
210 220 230 240 250
LEELPGDHVN IAVQVRGGPS DHEATAWILI NPLRKEDEGV YQCHAANMVG
260 270
EAESHSTVTV LDLSKYRSFH FPAPDDRM
Length:278
Mass (Da):29,005
Last modified:March 1, 2002 - v1
Checksum:iC159031F05739B6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135785 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58251.1
CCDSiCCDS35017.1
RefSeqiNP_001007564.1, NM_001007563.2
UniGeneiHs.349705

Genome annotation databases

EnsembliENST00000377694; ENSP00000366923; ENSG00000137142
GeneIDi347252
KEGGihsa:347252
UCSCiuc004aaz.4 human

Similar proteinsi

Entry informationi

Entry nameiIBPL1_HUMAN
AccessioniPrimary (citable) accession number: Q8WX77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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