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Q8WX77 (IBPL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor-binding protein-like 1
Alternative name(s):
IGFBP-related protein 10
Insulin-like growth factor-binding-related protein 4
Short name=IGFBP-rP4
Gene names
Name:IGFBPL1
Synonyms:IGFBPRP4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors By similarity. May be a putative tumor suppressor protein. Ref.1

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung. Ref.1

Induction

Down-regulated in multiple tumors.

Sequence similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 Kazal-like domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainImmunoglobulin domain
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of cell growth

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 278253Insulin-like growth factor-binding protein-like 1
PRO_0000297687

Regions

Domain34 – 10976IGFBP N-terminal
Domain95 – 15359Kazal-like
Domain155 – 259105Ig-like C2-type

Amino acid modifications

Glycosylation1661N-linked (GlcNAc...) Potential
Disulfide bond176 ↔ 243 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8WX77 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: C159031F05739B6F

FASTA27829,005
        10         20         30         40         50         60 
MPRLSLLLPL LLLLLLPLLP PLSPSLGIRD VGGRRPKCGP CRPEGCPAPA PCPAPGISAL 

        70         80         90        100        110        120 
DECGCCARCL GAEGASCGGR AGGRCGPGLV CASQAAGAAP EGTGLCVCAQ RGTVCGSDGR 

       130        140        150        160        170        180 
SYPSVCALRL RARHTPRAHP GHLHKARDGP CEFAPVVVVP PRSVHNVTGA QVGLSCEVRA 

       190        200        210        220        230        240 
VPTPVITWRK VTKSPEGTQA LEELPGDHVN IAVQVRGGPS DHEATAWILI NPLRKEDEGV 

       250        260        270 
YQCHAANMVG EAESHSTVTV LDLSKYRSFH FPAPDDRM 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties."
Cai Z., Chen H.T., Boyle B., Rupp F., Funk W.D., Dedera D.A.
Biochem. Biophys. Res. Commun. 331:261-266(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
Tissue: Testis.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL135785 Genomic DNA. Translation: CAD13245.1.
CH471071 Genomic DNA. Translation: EAW58251.1.
CCDSCCDS35017.1.
RefSeqNP_001007564.1. NM_001007563.2.
UniGeneHs.349705.

3D structure databases

ProteinModelPortalQ8WX77.
SMRQ8WX77. Positions 41-139, 159-264.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131417. 1 interaction.
STRING9606.ENSP00000366923.

Polymorphism databases

DMDM74751604.

Proteomic databases

PaxDbQ8WX77.
PRIDEQ8WX77.

Protocols and materials databases

DNASU347252.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377694; ENSP00000366923; ENSG00000137142.
GeneID347252.
KEGGhsa:347252.
UCSCuc004aaz.3. human.

Organism-specific databases

CTD347252.
GeneCardsGC09M038396.
H-InvDBHIX0034802.
HGNCHGNC:20081. IGFBPL1.
HPAHPA051354.
MIM610413. gene.
neXtProtNX_Q8WX77.
PharmGKBPA134937275.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40288.
HOGENOMHOG000261684.
HOVERGENHBG031621.
InParanoidQ8WX77.
OMARDECGCC.
OrthoDBEOG7BW0M2.
PhylomeDBQ8WX77.
TreeFamTF331645.

Gene expression databases

BgeeQ8WX77.
CleanExHS_IGFBPL1.
GenevestigatorQ8WX77.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view]
PANTHERPTHR14186. PTHR14186. 1 hit.
PfamPF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF00050. Kazal_1. 1 hit.
[Graphical view]
PIRSFPIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTSM00121. IB. 1 hit.
SM00408. IGc2. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi347252.
NextBio99074.
PROQ8WX77.
SOURCESearch...

Entry information

Entry nameIBPL1_HUMAN
AccessionPrimary (citable) accession number: Q8WX77
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM