Q8WX77 (IBPL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Insulin-like growth factor-binding protein-like 1

Alternative name(s):
IGFBP-related protein 10
Insulin-like growth factor-binding-related protein 4
Short name=IGFBP-rP4

Gene names

Name:	IGFBPL1
Synonyms:	IGFBPRP4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors By similarity. May be a putative tumor suppressor protein. Ref.1
Subcellular location	Secreted Ref.1.
Tissue specificity	Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung. Ref.1
Induction	Down-regulated in multiple tumors.
Sequence similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 Kazal-like domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of cell growth Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 278	253	Insulin-like growth factor-binding protein-like 1		PRO_0000297687
Regions
	Domain	34 – 109	76	IGFBP N-terminal
	Domain	95 – 153	59	Kazal-like
	Domain	155 – 259	105	Ig-like C2-type
Amino acid modifications
	Glycosylation	166	1	N-linked (GlcNAc...) Potential
	Disulfide bond	176 ↔ 243		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8WX77 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: C159031F05739B6F	FASTA	278	29,005
	10 20 30 40 50 60 MPRLSLLLPL LLLLLLPLLP PLSPSLGIRD VGGRRPKCGP CRPEGCPAPA PCPAPGISAL 70 80 90 100 110 120 DECGCCARCL GAEGASCGGR AGGRCGPGLV CASQAAGAAP EGTGLCVCAQ RGTVCGSDGR 130 140 150 160 170 180 SYPSVCALRL RARHTPRAHP GHLHKARDGP CEFAPVVVVP PRSVHNVTGA QVGLSCEVRA 190 200 210 220 230 240 VPTPVITWRK VTKSPEGTQA LEELPGDHVN IAVQVRGGPS DHEATAWILI NPLRKEDEGV 250 260 270 YQCHAANMVG EAESHSTVTV LDLSKYRSFH FPAPDDRM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties." Cai Z., Chen H.T., Boyle B., Rupp F., Funk W.D., Dedera D.A. Biochem. Biophys. Res. Commun. 331:261-266(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION. Tissue: Testis.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL135785 Genomic DNA. Translation: CAD13245.1. CH471071 Genomic DNA. Translation: EAW58251.1.
IPI	IPI00291987.
RefSeq	NP_001007564.1. NM_001007563.2.
UniGene	Hs.349705.
3D structure databases
HSSP	HSSP built from PDB template 1LR7 based on UniProtKB P21674.
ProteinModelPortal	Q8WX77.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000366923.
Polymorphism databases
DMDM	74751604.
Proteomic databases
PaxDb	Q8WX77.
PRIDE	Q8WX77.
Protocols and materials databases
DNASU	347252.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377694; ENSP00000366923; ENSG00000137142.
GeneID	347252.
KEGG	hsa:347252.
UCSC	uc004aba.3. human.
Organism-specific databases
CTD	347252.
GeneCards	GC09M038396.
H-InvDB	HIX0034802.
HGNC	HGNC:20081. IGFBPL1.
HPA	HPA051354.
MIM	610413. gene.
neXtProt	NX_Q8WX77.
PharmGKB	PA134937275.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40288.
HOGENOM	HOG000261684.
HOVERGEN	HBG031621.
InParanoid	Q8WX77.
OMA	RDECGCC.
OrthoDB	EOG44TP8X.
PhylomeDB	Q8WX77.
Gene expression databases
Bgee	Q8WX77.
CleanEx	HS_IGFBPL1.
Genevestigator	Q8WX77.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR000867. IGFBP-like. IPR011390. IGFBP_rP_mac25. IPR002350. Kazal_dom. [Graphical view]
PANTHER	PTHR14186. PTHR14186. 1 hit.
Pfam	PF07679. I-set. 1 hit. PF00219. IGFBP. 1 hit. PF00050. Kazal_1. 1 hit. [Graphical view]
PIRSF	PIRSF018239. IGFBP_rP_mac25. 1 hit.
SMART	SM00121. IB. 1 hit. SM00408. IGc2. 1 hit. SM00280. KAZAL. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS51465. KAZAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	347252.
NextBio	99074.
SOURCE	Search...

Entry information

Entry name

IBPL1_HUMAN

Accession

Primary (citable) accession number: Q8WX77

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.