Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WX77

- IBPL1_HUMAN

UniProt

Q8WX77 - IBPL1_HUMAN

Protein

Insulin-like growth factor-binding protein-like 1

Gene

IGFBPL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors By similarity. May be a putative tumor suppressor protein.By similarity1 Publication

    GO - Biological processi

    1. regulation of cell growth Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein-like 1
    Alternative name(s):
    IGFBP-related protein 10
    Insulin-like growth factor-binding-related protein 4
    Short name:
    IGFBP-rP4
    Gene namesi
    Name:IGFBPL1
    Synonyms:IGFBPRP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:20081. IGFBPL1.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134937275.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 278253Insulin-like growth factor-binding protein-like 1PRO_0000297687Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi176 ↔ 243PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8WX77.
    PRIDEiQ8WX77.

    Expressioni

    Tissue specificityi

    Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.1 Publication

    Inductioni

    Down-regulated in multiple tumors.

    Gene expression databases

    BgeeiQ8WX77.
    CleanExiHS_IGFBPL1.
    GenevestigatoriQ8WX77.

    Organism-specific databases

    HPAiHPA051354.

    Interactioni

    Protein-protein interaction databases

    BioGridi131417. 1 interaction.
    STRINGi9606.ENSP00000366923.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WX77.
    SMRiQ8WX77. Positions 41-139, 159-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 10976IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini95 – 15359Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini155 – 259105Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG40288.
    HOGENOMiHOG000261684.
    HOVERGENiHBG031621.
    InParanoidiQ8WX77.
    OMAiRDECGCC.
    OrthoDBiEOG7BW0M2.
    PhylomeDBiQ8WX77.
    TreeFamiTF331645.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR000867. IGFBP-like.
    IPR011390. IGFBP_rP_mac25.
    IPR002350. Kazal_dom.
    [Graphical view]
    PANTHERiPTHR14186. PTHR14186. 1 hit.
    PfamiPF07679. I-set. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00050. Kazal_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
    SMARTiSM00121. IB. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WX77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRLSLLLPL LLLLLLPLLP PLSPSLGIRD VGGRRPKCGP CRPEGCPAPA    50
    PCPAPGISAL DECGCCARCL GAEGASCGGR AGGRCGPGLV CASQAAGAAP 100
    EGTGLCVCAQ RGTVCGSDGR SYPSVCALRL RARHTPRAHP GHLHKARDGP 150
    CEFAPVVVVP PRSVHNVTGA QVGLSCEVRA VPTPVITWRK VTKSPEGTQA 200
    LEELPGDHVN IAVQVRGGPS DHEATAWILI NPLRKEDEGV YQCHAANMVG 250
    EAESHSTVTV LDLSKYRSFH FPAPDDRM 278
    Length:278
    Mass (Da):29,005
    Last modified:March 1, 2002 - v1
    Checksum:iC159031F05739B6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL135785 Genomic DNA. Translation: CAD13245.1.
    CH471071 Genomic DNA. Translation: EAW58251.1.
    CCDSiCCDS35017.1.
    RefSeqiNP_001007564.1. NM_001007563.2.
    UniGeneiHs.349705.

    Genome annotation databases

    EnsembliENST00000377694; ENSP00000366923; ENSG00000137142.
    GeneIDi347252.
    KEGGihsa:347252.
    UCSCiuc004aaz.3. human.

    Polymorphism databases

    DMDMi74751604.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL135785 Genomic DNA. Translation: CAD13245.1 .
    CH471071 Genomic DNA. Translation: EAW58251.1 .
    CCDSi CCDS35017.1.
    RefSeqi NP_001007564.1. NM_001007563.2.
    UniGenei Hs.349705.

    3D structure databases

    ProteinModelPortali Q8WX77.
    SMRi Q8WX77. Positions 41-139, 159-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131417. 1 interaction.
    STRINGi 9606.ENSP00000366923.

    Polymorphism databases

    DMDMi 74751604.

    Proteomic databases

    PaxDbi Q8WX77.
    PRIDEi Q8WX77.

    Protocols and materials databases

    DNASUi 347252.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377694 ; ENSP00000366923 ; ENSG00000137142 .
    GeneIDi 347252.
    KEGGi hsa:347252.
    UCSCi uc004aaz.3. human.

    Organism-specific databases

    CTDi 347252.
    GeneCardsi GC09M038396.
    H-InvDB HIX0034802.
    HGNCi HGNC:20081. IGFBPL1.
    HPAi HPA051354.
    MIMi 610413. gene.
    neXtProti NX_Q8WX77.
    PharmGKBi PA134937275.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40288.
    HOGENOMi HOG000261684.
    HOVERGENi HBG031621.
    InParanoidi Q8WX77.
    OMAi RDECGCC.
    OrthoDBi EOG7BW0M2.
    PhylomeDBi Q8WX77.
    TreeFami TF331645.

    Miscellaneous databases

    GenomeRNAii 347252.
    NextBioi 99074.
    PROi Q8WX77.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WX77.
    CleanExi HS_IGFBPL1.
    Genevestigatori Q8WX77.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR000867. IGFBP-like.
    IPR011390. IGFBP_rP_mac25.
    IPR002350. Kazal_dom.
    [Graphical view ]
    PANTHERi PTHR14186. PTHR14186. 1 hit.
    Pfami PF07679. I-set. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00050. Kazal_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018239. IGFBP_rP_mac25. 1 hit.
    SMARTi SM00121. IB. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties."
      Cai Z., Chen H.T., Boyle B., Rupp F., Funk W.D., Dedera D.A.
      Biochem. Biophys. Res. Commun. 331:261-266(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
      Tissue: Testis.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiIBPL1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WX77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3