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Q8WX77

- IBPL1_HUMAN

UniProt

Q8WX77 - IBPL1_HUMAN

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Protein

Insulin-like growth factor-binding protein-like 1

Gene

IGFBPL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.By similarity1 Publication

GO - Biological processi

  1. regulation of cell growth Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein-like 1
Alternative name(s):
IGFBP-related protein 10
Insulin-like growth factor-binding-related protein 4
Short name:
IGFBP-rP4
Gene namesi
Name:IGFBPL1
Synonyms:IGFBPRP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:20081. IGFBPL1.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937275.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 278253Insulin-like growth factor-binding protein-like 1PRO_0000297687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi176 ↔ 243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WX77.
PRIDEiQ8WX77.

Expressioni

Tissue specificityi

Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.1 Publication

Inductioni

Down-regulated in multiple tumors.

Gene expression databases

BgeeiQ8WX77.
CleanExiHS_IGFBPL1.
GenevestigatoriQ8WX77.

Organism-specific databases

HPAiHPA051354.

Interactioni

Protein-protein interaction databases

BioGridi131417. 1 interaction.
STRINGi9606.ENSP00000366923.

Structurei

3D structure databases

ProteinModelPortaliQ8WX77.
SMRiQ8WX77. Positions 41-139, 157-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10976IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini95 – 15359Kazal-likePROSITE-ProRule annotationAdd
BLAST
Domaini155 – 259105Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG40288.
GeneTreeiENSGT00530000063555.
HOGENOMiHOG000261684.
HOVERGENiHBG031621.
InParanoidiQ8WX77.
OMAiRDECGCC.
OrthoDBiEOG7BW0M2.
PhylomeDBiQ8WX77.
TreeFamiTF331645.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view]
PANTHERiPTHR14186. PTHR14186. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF00050. Kazal_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTiSM00121. IB. 1 hit.
SM00408. IGc2. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WX77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRLSLLLPL LLLLLLPLLP PLSPSLGIRD VGGRRPKCGP CRPEGCPAPA
60 70 80 90 100
PCPAPGISAL DECGCCARCL GAEGASCGGR AGGRCGPGLV CASQAAGAAP
110 120 130 140 150
EGTGLCVCAQ RGTVCGSDGR SYPSVCALRL RARHTPRAHP GHLHKARDGP
160 170 180 190 200
CEFAPVVVVP PRSVHNVTGA QVGLSCEVRA VPTPVITWRK VTKSPEGTQA
210 220 230 240 250
LEELPGDHVN IAVQVRGGPS DHEATAWILI NPLRKEDEGV YQCHAANMVG
260 270
EAESHSTVTV LDLSKYRSFH FPAPDDRM
Length:278
Mass (Da):29,005
Last modified:March 1, 2002 - v1
Checksum:iC159031F05739B6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135785 Genomic DNA. Translation: CAD13245.1.
CH471071 Genomic DNA. Translation: EAW58251.1.
CCDSiCCDS35017.1.
RefSeqiNP_001007564.1. NM_001007563.2.
UniGeneiHs.349705.

Genome annotation databases

EnsembliENST00000377694; ENSP00000366923; ENSG00000137142.
GeneIDi347252.
KEGGihsa:347252.
UCSCiuc004aaz.3. human.

Polymorphism databases

DMDMi74751604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135785 Genomic DNA. Translation: CAD13245.1 .
CH471071 Genomic DNA. Translation: EAW58251.1 .
CCDSi CCDS35017.1.
RefSeqi NP_001007564.1. NM_001007563.2.
UniGenei Hs.349705.

3D structure databases

ProteinModelPortali Q8WX77.
SMRi Q8WX77. Positions 41-139, 157-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131417. 1 interaction.
STRINGi 9606.ENSP00000366923.

Protein family/group databases

MEROPSi I43.001.

Polymorphism databases

DMDMi 74751604.

Proteomic databases

PaxDbi Q8WX77.
PRIDEi Q8WX77.

Protocols and materials databases

DNASUi 347252.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377694 ; ENSP00000366923 ; ENSG00000137142 .
GeneIDi 347252.
KEGGi hsa:347252.
UCSCi uc004aaz.3. human.

Organism-specific databases

CTDi 347252.
GeneCardsi GC09M038396.
H-InvDB HIX0034802.
HGNCi HGNC:20081. IGFBPL1.
HPAi HPA051354.
MIMi 610413. gene.
neXtProti NX_Q8WX77.
PharmGKBi PA134937275.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40288.
GeneTreei ENSGT00530000063555.
HOGENOMi HOG000261684.
HOVERGENi HBG031621.
InParanoidi Q8WX77.
OMAi RDECGCC.
OrthoDBi EOG7BW0M2.
PhylomeDBi Q8WX77.
TreeFami TF331645.

Miscellaneous databases

GenomeRNAii 347252.
NextBioi 99074.
PROi Q8WX77.
SOURCEi Search...

Gene expression databases

Bgeei Q8WX77.
CleanExi HS_IGFBPL1.
Genevestigatori Q8WX77.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view ]
PANTHERi PTHR14186. PTHR14186. 1 hit.
Pfami PF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF00050. Kazal_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTi SM00121. IB. 1 hit.
SM00408. IGc2. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties."
    Cai Z., Chen H.T., Boyle B., Rupp F., Funk W.D., Dedera D.A.
    Biochem. Biophys. Res. Commun. 331:261-266(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
    Tissue: Testis.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiIBPL1_HUMAN
AccessioniPrimary (citable) accession number: Q8WX77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3